                         б

<110>  ѸƼɷ޹˾
 
<120>  һֿPD-L1弰ƱӦ

<130>  PCT190486PPC

<160>  144   

<170>  PatentIn version 3.3

<210>  1
<211>  26
<212>  PRT
<213>  ˹ϳ

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  2
<211>  17
<212>  PRT
<213>  ˹ϳ

<400>  2

Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  3
<211>  36
<212>  PRT
<213>  ˹ϳ

<400>  3

Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly 
1               5                   10                  15      


Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  4
<211>  10
<212>  PRT
<213>  ˹ϳ

<400>  4

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  5
<211>  24
<212>  PRT
<213>  ˹ϳ

<400>  5

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser 
            20                  


<210>  6
<211>  17
<212>  PRT
<213>  ˹ϳ

<400>  6

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Ala 
    


<210>  7
<211>  38
<212>  PRT
<213>  ˹ϳ

<400>  7

Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Val Thr 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  8
<211>  10
<212>  PRT
<213>  ˹ϳ

<400>  8

Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
1               5                   10  


<210>  9
<211>  22
<212>  PRT
<213>  ˹ϳ

<400>  9

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser 
            20          


<210>  10
<211>  17
<212>  PRT
<213>  ˹ϳ

<400>  10

Met His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  11
<211>  36
<212>  PRT
<213>  ˹ϳ

<400>  11

Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  12
<211>  10
<212>  PRT
<213>  ˹ϳ

<400>  12

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  13
<211>  24
<212>  PRT
<213>  ˹ϳ

<400>  13

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser 
            20                  


<210>  14
<211>  17
<212>  PRT
<213>  ˹ϳ

<400>  14

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  15
<211>  38
<212>  PRT
<213>  ˹ϳ

<400>  15

Lys Tyr Asn Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ser Asp Lys 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  16
<211>  10
<212>  PRT
<213>  ˹ϳ

<400>  16

Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
1               5                   10  


<210>  17
<211>  6
<212>  PRT
<213>  ˹ϳ

<400>  17

Gln Asp Leu Gly Asn Thr 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  ˹ϳ

<400>  18

Gln Asn Ile Gly Gln Thr 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  ˹ϳ

<400>  19

Gln Asn Ile Ala Asn Thr 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  ˹ϳ

<400>  20

Gln Asp Val Gly Gln Thr 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  ˹ϳ

<400>  21

Gln Glu Ile Gly Gln Thr 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  ˹ϳ

<400>  22

Gln Asn Gly Ile Asn Thr 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  ˹ϳ

<400>  23

Gln Asp Ile Gly Asn Thr 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  ˹ϳ

<400>  24

Gln Glu Ile Gly Gln Thr 
1               5       


<210>  25
<211>  3
<212>  PRT
<213>  ˹ϳ

<400>  25

Ala Thr Ser 
1           


<210>  26
<211>  3
<212>  PRT
<213>  ˹ϳ

<400>  26

Ala Ser Ser 
1           


<210>  27
<211>  3
<212>  PRT
<213>  ˹ϳ

<400>  27

Gly Thr Ser 
1           


<210>  28
<211>  3
<212>  PRT
<213>  ˹ϳ

<400>  28

Ser Thr Ser 
1           


<210>  29
<211>  3
<212>  PRT
<213>  ˹ϳ

<400>  29

Val Ser Ser 
1           


<210>  30
<211>  3
<212>  PRT
<213>  ˹ϳ

<400>  30

Val Thr Ser 
1           


<210>  31
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  31

Leu Gln Tyr Ala Ser Tyr Pro Phe Thr 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  32

Leu Tyr Phe Ala Ser Ser Pro Phe Thr 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  33

Leu Gln Tyr Ala Ser Ser Pro Phe Thr 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  34

Leu Tyr Tyr Ala Ser Tyr Phe Phe Thr 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  35

Leu Gln Tyr Ala Ser Ser Phe Phe Thr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  36

Leu Asn Tyr Ile Ser Ser Pro Phe Thr 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  37

Leu Gln Tyr Ala Ser Thr Phe Phe Thr 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  38

Leu Tyr Tyr Ala Ser Thr Pro Phe Thr 
1               5                   


<210>  39
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  39

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  40

Gly Tyr Ser Tyr Tyr Phe Tyr Trp 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  41

Gly Tyr Ser Phe Ser Ser Tyr Trp 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  42

Gly Tyr Thr Tyr Tyr Phe Tyr Trp 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  43

Gly Tyr Ser Phe Thr Thr Tyr Trp 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  44

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  45

Gly Tyr Thr Tyr Asn Phe Tyr Trp 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  46

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  47

Ile Tyr His Gly Asn Ser Glu Thr 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  48

Ile Tyr Pro Val His Ser Glu Thr 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  49

Ile Tyr His Val Gln Ser Asp Thr 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  50

Ile Tyr Pro Gly Gln Ser Glu Thr 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  51

Ile Tyr Trp Ala His Ser Glu Thr 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  52

Ile Tyr His Ile Asn Ser Asp Thr 
1               5               


<210>  53
<211>  13
<212>  PRT
<213>  ˹ϳ

<400>  53

Thr Arg Trp Gly Glu Gly Tyr Tyr His Ala Met Asn His 
1               5                   10              


<210>  54
<211>  13
<212>  PRT
<213>  ˹ϳ

<400>  54

Thr His Trp Ala Asp Ala Tyr Phe His Gly Met Asn His 
1               5                   10              


<210>  55
<211>  13
<212>  PRT
<213>  ˹ϳ

<400>  55

Thr His Trp Leu Glu Val Tyr Phe His Gly Met Asp His 
1               5                   10              


<210>  56
<211>  13
<212>  PRT
<213>  ˹ϳ

<400>  56

Thr Arg Trp Ala Glu Leu Phe Phe His Ala Met Asp His 
1               5                   10              


<210>  57
<211>  13
<212>  PRT
<213>  ˹ϳ

<400>  57

Thr Arg Trp Gly Asp Gly Tyr Tyr His Ala Met Asp His 
1               5                   10              


<210>  58
<211>  13
<212>  PRT
<213>  ˹ϳ

<400>  58

Thr Arg Trp Leu Asp Ala Phe Tyr His Val Met Asp His 
1               5                   10              


<210>  59
<211>  13
<212>  PRT
<213>  ˹ϳ

<400>  59

Thr His Trp Val Glu Val Phe Tyr His Ala Met Glu His 
1               5                   10              


<210>  60
<211>  13
<212>  PRT
<213>  ˹ϳ

<400>  60

Thr His Trp Ile Asp Gly Tyr Phe His Val Met Asp His 
1               5                   10              


<210>  61
<211>  13
<212>  PRT
<213>  ˹ϳ

<400>  61

Thr His Trp Ala Glu Gly Tyr Tyr His Ala Met Glu His 
1               5                   10              


<210>  62
<211>  13
<212>  PRT
<213>  ˹ϳ

<400>  62

Thr His Trp Ile Glu Ala Phe Phe His Leu Met Gln His 
1               5                   10              


<210>  63
<211>  5
<212>  PRT
<213>  ˹ϳ

<400>  63

Ser Ser Val Ser Tyr 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  ˹ϳ

<400>  64

Ser Thr Val Tyr Tyr 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  ˹ϳ

<400>  65

Ser Ser Gly Tyr Tyr 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  ˹ϳ

<400>  66

Ser Ser Ala Ser Tyr 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  ˹ϳ

<400>  67

Ser Thr Ile Thr Tyr 
1               5   


<210>  68
<211>  5
<212>  PRT
<213>  ˹ϳ

<400>  68

Ser Ser Ile Ser Tyr 
1               5   


<210>  69
<211>  3
<212>  PRT
<213>  ˹ϳ

<400>  69

Ser Tyr Ser 
1           


<210>  70
<211>  3
<212>  PRT
<213>  ˹ϳ

<400>  70

Ser Thr Ser 
1           


<210>  71
<211>  3
<212>  PRT
<213>  ˹ϳ

<400>  71

Thr Thr Ser 
1           


<210>  72
<211>  3
<212>  PRT
<213>  ˹ϳ

<400>  72

Tyr Thr Ser 
1           


<210>  73
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  73

Gln Gln Arg Ser Ser Phe Pro Tyr Thr 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  74

Gln Asn Arg Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  75

Gln Gln Arg Ser Ser Tyr His Tyr Thr 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  76

Gln Asn Arg Thr Ser Phe His Tyr Thr 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  77

Gln Tyr Arg Phe Ser Tyr Trp Tyr Thr 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  78

Gln Tyr Arg Thr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  79

Gln Gln Arg Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  80

Gln Gln Arg Phe Ser Phe His Tyr Thr 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  81

Gln Tyr Arg Ser Ser Tyr Trp Tyr Thr 
1               5                   


<210>  82
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  82

Gly Tyr Ser Thr Ser Ser Phe Val 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  83

Gly Tyr Tyr Thr Ser Ser Pro Val 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  84

Gly Tyr Tyr Thr Thr Ser Tyr Val 
1               5               


<210>  85
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  85

Gly Tyr Ser Phe Thr Ser Tyr Val 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  86

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  87

Gly Tyr Phe Tyr Thr Ser Tyr Val 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  88

Gly Tyr Phe Phe Ser Ser Phe Val 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  89

Ile Asn Tyr Tyr Asn Asp Ala Thr 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  90

Ile Asn Tyr Phe Tyr Asp Gly Thr 
1               5               


<210>  91
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  91

Ile Asn Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  92
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  92

Ile Asn Tyr Tyr Asn Asp Ala Thr 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  93

Ile Asn His Phe Gln Asp Ala Thr 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  94

Ile Asn Pro Phe Gln Asp Ile Thr 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  ˹ϳ

<400>  95

Ile Asn Pro Tyr Tyr Asp Gly Thr 
1               5               


<210>  96
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  96

Ala Trp Ser Gly Ala Ile Phe Glu Tyr 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  97

Ala Arg Ser Ile Gly Ile Thr Asp Tyr 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  98

Ala Lys Ser Ala Ile Ala Phe Glu Tyr 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  99

Ala Lys Ser Gly Gly Ile Ser Asp Tyr 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  100

Ala Trp Ser Ala Ala Leu Ser Glu Tyr 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  101

Ala Arg Ser Val Gly Ile Thr Asp Tyr 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  102

Ala Arg Ser Ala Ala Leu Ser Glu Tyr 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  103

Ala Arg Ser Gly Gly Ile Phe Asp Tyr 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  ˹ϳ

<400>  104

Ala Lys Ser Leu Val Gly Ser Glu Tyr 
1               5                   


<210>  105
<211>  107
<212>  PRT
<213>  ˹ϳ

<400>  105

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  106
<211>  118
<212>  PRT
<213>  ˹ϳ

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  107
<211>  107
<212>  PRT
<213>  ˹ϳ

<400>  107

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Leu Gly Asn Thr 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ser Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Tyr Tyr Ala Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  108
<211>  107
<212>  PRT
<213>  ˹ϳ

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Thr 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  109
<211>  107
<212>  PRT
<213>  ˹ϳ

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Ala Asn Thr 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Val Ser Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Tyr Tyr Ala Ser Tyr Phe Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  110
<211>  107
<212>  PRT
<213>  ˹ϳ

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Gly Gln Thr 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Val Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Tyr Phe Ala Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  111
<211>  107
<212>  PRT
<213>  ˹ϳ

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Gly Ile Asn Thr 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Val Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Tyr Tyr Ala Ser Tyr Phe Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  112
<211>  107
<212>  PRT
<213>  ˹ϳ

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Gly Gln Thr 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Asn Tyr Ile Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  113
<211>  107
<212>  PRT
<213>  ˹ϳ

<400>  113

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Gly Gln Thr 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Tyr Tyr Ala Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  114
<211>  107
<212>  PRT
<213>  ˹ϳ

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Gln Thr 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ser Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  115
<211>  118
<212>  PRT
<213>  ˹ϳ

<400>  115

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Tyr Tyr Phe Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ala Ile Tyr His Ile Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Trp Gly Glu Gly Tyr Tyr His Ala Met Asn His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  116
<211>  118
<212>  PRT
<213>  ˹ϳ

<400>  116

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Trp Gly Asp Gly Tyr Tyr His Ala Met Asp His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  117
<211>  118
<212>  PRT
<213>  ˹ϳ

<400>  117

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Tyr Tyr Phe Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ala Ile Tyr His Gly Asn Ser Glu Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


His Trp Ala Asp Ala Tyr Phe His Gly Met Asn His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  118
<211>  118
<212>  PRT
<213>  ˹ϳ

<400>  118

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Tyr Asn Phe Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ala Ile Tyr His Val Gln Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


His Trp Leu Glu Val Tyr Phe His Gly Met Asp His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  119
<211>  118
<212>  PRT
<213>  ˹ϳ

<400>  119

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ala Ile Tyr Trp Ala His Ser Glu Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


His Trp Leu Glu Val Tyr Phe His Gly Met Asp His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  120
<211>  118
<212>  PRT
<213>  ˹ϳ

<400>  120

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Ser Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ala Ile Tyr Pro Gly Gln Ser Glu Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


His Trp Ile Asp Gly Tyr Phe His Val Met Asp His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  121
<211>  118
<212>  PRT
<213>  ˹ϳ

<400>  121

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ala Ile Tyr Trp Ala His Ser Glu Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Trp Gly Asp Gly Tyr Tyr His Ala Met Asp His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  122
<211>  118
<212>  PRT
<213>  ˹ϳ

<400>  122

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr Trp 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ala Ile Tyr Pro Val His Ser Glu Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


His Trp Ile Glu Ala Phe Phe His Leu Met Gln His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  123
<211>  102
<212>  PRT
<213>  ˹ϳ

<400>  123

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Tyr Ser Asn 
        35                  40                  45              


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Asn Arg Thr Ser Phe His Tyr Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  124
<211>  102
<212>  PRT
<213>  ˹ϳ

<400>  124

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser Ser Thr Val Tyr Tyr Met His Trp Phe Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn 
        35                  40                  45              


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Tyr Arg Ser Ser Tyr Trp Tyr Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  125
<211>  102
<212>  PRT
<213>  ˹ϳ

<400>  125

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser Ser Ser Val Tyr Tyr Met His Trp Phe Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Tyr Ser Asn 
        35                  40                  45              


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Tyr Arg Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  126
<211>  102
<212>  PRT
<213>  ˹ϳ

<400>  126

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met His Trp Phe Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn 
        35                  40                  45              


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Arg Ser Ser Phe Pro Tyr Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  127
<211>  102
<212>  PRT
<213>  ˹ϳ

<400>  127

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser Ser Thr Ile Thr Tyr Met His Trp Phe Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Tyr Thr Ser Asn 
        35                  40                  45              


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Asn Arg Thr Ser Phe His Tyr Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  128
<211>  102
<212>  PRT
<213>  ˹ϳ

<400>  128

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn 
        35                  40                  45              


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  129
<211>  102
<212>  PRT
<213>  ˹ϳ

<400>  129

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn 
        35                  40                  45              


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Asn Arg Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  130
<211>  102
<212>  PRT
<213>  ˹ϳ

<400>  130

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser Ser Thr Val Tyr Tyr Met His Trp Phe Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Tyr Ser Asn 
        35                  40                  45              


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr His Tyr Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  131
<211>  102
<212>  PRT
<213>  ˹ϳ

<400>  131

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser Ser Ser Ala Ser Tyr Met His Trp Phe Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Tyr Ser Asn 
        35                  40                  45              


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Tyr Arg Thr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  132
<211>  102
<212>  PRT
<213>  ˹ϳ

<400>  132

Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ala Ser Ser Ser Gly Tyr Tyr Met His Trp Phe Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Thr Thr Ser Asn 
        35                  40                  45              


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly 
                85                  90                  95      


Thr Lys Leu Glu Ile Lys 
            100         


<210>  133
<211>  114
<212>  PRT
<213>  ˹ϳ

<400>  133

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Thr Ser Ser Phe Val 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Asn Tyr Tyr Asn Asp Ala Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Trp Ser Gly Ala Ile Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  134
<211>  114
<212>  PRT
<213>  ˹ϳ

<400>  134

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Tyr Thr Ser Ser Pro Val 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Asn Tyr Phe Tyr Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Ser Ala Ile Ala Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  135
<211>  114
<212>  PRT
<213>  ˹ϳ

<400>  135

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Tyr Thr Thr Ser Tyr Val 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Asn Pro Tyr Tyr Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Gly Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  136
<211>  114
<212>  PRT
<213>  ˹ϳ

<400>  136

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Val 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Ile Gly Ile Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  137
<211>  114
<212>  PRT
<213>  ˹ϳ

<400>  137

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Phe Phe Ser Ser Phe Val 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Asn Tyr Tyr Asn Asp Ala Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Ala Ala Leu Ser Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  138
<211>  114
<212>  PRT
<213>  ˹ϳ

<400>  138

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Trp Ser Gly Ala Ile Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  139
<211>  114
<212>  PRT
<213>  ˹ϳ

<400>  139

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Phe Tyr Thr Ser Tyr Val 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Asn Pro Phe Gln Asp Ile Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Trp Ser Ala Ala Leu Ser Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  140
<211>  114
<212>  PRT
<213>  ˹ϳ

<400>  140

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Phe Phe Ser Ser Phe Val 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Asn His Phe Gln Asp Ala Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Val Gly Ile Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  141
<211>  114
<212>  PRT
<213>  ˹ϳ

<400>  141

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Tyr Thr Ser Ser Pro Val 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Ser Gly Gly Ile Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  142
<211>  114
<212>  PRT
<213>  ˹ϳ

<400>  142

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Tyr Thr Thr Ser Tyr Val 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Asn His Phe Gln Asp Ala Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ser Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Trp Ser Gly Ala Ile Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  143
<211>  107
<212>  PRT
<213>  ˹ϳ

<400>  143

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  144
<211>  328
<212>  PRT
<213>  ˹ϳ

<400>  144

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
1               5                   10                  15      


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
65                  70                  75                  80  


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
                85                  90                  95      


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
            100                 105                 110         


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    130                 135                 140                 


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
145                 150                 155                 160 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                165                 170                 175     


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            180                 185                 190         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
        195                 200                 205             


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    210                 215                 220                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
225                 230                 235                 240 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                245                 250                 255     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            260                 265                 270         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        275                 280                 285             


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
    290                 295                 300                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
305                 310                 315                 320 


Ser Leu Ser Leu Ser Leu Gly Lys 
                325             


