                         SEQUENCE LISTING

<110>  KINDRED BIOSCIENCES, INC.
 
<120>  ANTI-IL4 RECEPTOR ANTIBODIES FOR VETERINARY USE

<130>  01157-0016-00PCT

<150>  US 62/731,633
<151>  2018-09-14

<160>  357   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H1

<400>  1

Gly Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H2


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X is K or A

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  X is K or A

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  X is F or V

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  X is K or Q

<400>  2

Tyr Ile Asn Pro Xaa Asn Asp Gly Thr Phe Tyr Asn Gly Xaa Xaa Xaa 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H3


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X is N or Y

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X is I or F

<400>  3

Phe Xaa Tyr Gly Xaa Ala Tyr 
1               5           


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-L1

<400>  4

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-L2


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is T or N

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X is R or L

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X is S or T

<400>  5

Ala Ala Ser Xaa Xaa Asp Xaa 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-L3

<400>  6

Val Gln Tyr Ala Ser Tyr Pro Trp Thr 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B CDR-H1

<400>  7

Gly Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   10  


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B CDR-H2

<400>  8

Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B CDR-H3

<400>  9

Phe Asn Tyr Gly Ile Ala Tyr 
1               5           


<210>  10
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B HC-FR1

<400>  10

Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B HC-FR2

<400>  11

Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  12
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B HC-FR3

<400>  12

Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B HC-FR4

<400>  13

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B CDR-L1

<400>  14

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B CDR-L2

<400>  15

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B CDR-L3

<400>  16

Val Gln Tyr Ala Ser Tyr Pro Trp Thr 
1               5                   


<210>  17
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B LC-FR1

<400>  17

Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser 
            20                  25      


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B LC-FR2

<400>  18

Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  19
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B LC-FR3

<400>  19

Gly Val Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Phe Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B LC-FR4

<400>  20

Phe Gly Gly Gly Ala Arg Leu Glu Ile Lys 
1               5                   10  


<210>  21
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B variable HC

<400>  21

Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  22
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B variable LC

<400>  22

Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Glu 
1               5                   10                  15      


Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu 
            20                  25                  30          


Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly Ser 
    50                  55                  60                  


Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu 
65                  70                  75                  80  


Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Ala Arg Leu Glu Ile Lys 
            100                 105     


<210>  23
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B variable HC with leader sequence

<400>  23

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser 
    130                 135 


<210>  24
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B variable LC with leader sequence

<400>  24

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile 
        35                  40                  45              


Ser Gly Tyr Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys 
    50                  55                  60                  


Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Ser 
            100                 105                 110         


Tyr Pro Trp Thr Phe Gly Gly Gly Ala Arg Leu Glu Ile Lys 
        115                 120                 125     


<210>  25
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B HC

<400>  25

Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg Pro 
            180                 185                 190         


Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile 
    210                 215                 220                 


Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val 
            260                 265                 270         


Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala 
305                 310                 315                 320 


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro 
                325                 330                 335     


Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala 
            340                 345                 350         


Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu 
        355                 360                 365             


Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 
    370                 375                 380                 


Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser Tyr Phe Val Tyr 
385                 390                 395                 400 


Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe 
                405                 410                 415     


Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys 
            420                 425                 430         


Ser Leu Ser His Ser Pro Gly Lys 
        435                 440 


<210>  26
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B LC

<400>  26

Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Glu 
1               5                   10                  15      


Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu 
            20                  25                  30          


Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly Ser 
    50                  55                  60                  


Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu 
65                  70                  75                  80  


Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Ala Arg Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  27
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B HC with leader sequence

<400>  27

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
        195                 200                 205             


Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser 
    210                 215                 220                 


Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys 
225                 230                 235                 240 


Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser 
        275                 280                 285             


Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile 
305                 310                 315                 320 


Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn 
                325                 330                 335     


Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            340                 345                 350         


Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu 
        355                 360                 365             


Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe 
    370                 375                 380                 


Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala 
385                 390                 395                 400 


Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser Tyr 
                405                 410                 415     


Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly 
            420                 425                 430         


Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His 
        435                 440                 445             


Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 


<210>  28
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone B LC with leader sequence

<400>  28

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile 
        35                  40                  45              


Ser Gly Tyr Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys 
    50                  55                  60                  


Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Ser 
            100                 105                 110         


Tyr Pro Trp Thr Phe Gly Gly Gly Ala Arg Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I CDR-H1

<400>  29

Gly Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   10  


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I CDR-H2

<400>  30

Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I CDR-H3

<400>  31

Phe Tyr Tyr Gly Phe Ala Tyr 
1               5           


<210>  32
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I HC-FR1

<400>  32

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I HC-FR2

<400>  33

Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  34
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I HC-FR3

<400>  34

Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I HC-FR4

<400>  35

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I CDR-L1

<400>  36

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I CDR-L2

<400>  37

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I CDR-L3

<400>  38

Leu Gln Tyr Ala Ser Tyr Pro Trp Thr 
1               5                   


<210>  39
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I LC-FR1

<400>  39

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser 
            20                  25      


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I LC-FR2

<400>  40

Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  41
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I LC-FR3

<400>  41

Gly Val Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Phe Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I LC-FR4

<400>  42

Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys 
1               5                   10  


<210>  43
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I variable HC

<400>  43

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I variable LC

<400>  44

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys 
            100                 105         


<210>  45
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I variable HC with leader sequence

<400>  45

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala 
    130                 135 


<210>  46
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I variable LC with leader sequence

<400>  46

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu 
        35                  40                  45              


Ile Ser Gly Tyr Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala 
            100                 105                 110         


Ser Tyr Pro Trp Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  47
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I HC

<400>  47

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg Pro 
            180                 185                 190         


Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile 
    210                 215                 220                 


Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val 
            260                 265                 270         


Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala 
305                 310                 315                 320 


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro 
                325                 330                 335     


Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala 
            340                 345                 350         


Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu 
        355                 360                 365             


Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 
    370                 375                 380                 


Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser Tyr Phe Val Tyr 
385                 390                 395                 400 


Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe 
                405                 410                 415     


Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys 
            420                 425                 430         


Ser Leu Ser His Ser Pro Gly Lys 
        435                 440 


<210>  48
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I LC

<400>  48

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  49
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I HC with leader sequence

<400>  49

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
        195                 200                 205             


Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser 
    210                 215                 220                 


Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys 
225                 230                 235                 240 


Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser 
        275                 280                 285             


Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile 
305                 310                 315                 320 


Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn 
                325                 330                 335     


Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            340                 345                 350         


Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu 
        355                 360                 365             


Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe 
    370                 375                 380                 


Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala 
385                 390                 395                 400 


Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser Tyr 
                405                 410                 415     


Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly 
            420                 425                 430         


Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His 
        435                 440                 445             


Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 


<210>  50
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone I LC with leader sequence

<400>  50

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu 
        35                  40                  45              


Ile Ser Gly Tyr Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala 
            100                 105                 110         


Ser Tyr Pro Trp Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  51
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric Clone B variable HC and canine IgG-B 
       (Chimeric B HC)

<400>  51

Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  52
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric Clone B variable LC and canine ? light 
       constant region  (Chimeric B LC)

<400>  52

Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Glu 
1               5                   10                  15      


Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu 
            20                  25                  30          


Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly Ser 
    50                  55                  60                  


Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu 
65                  70                  75                  80  


Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Ala Arg Leu Glu Ile Lys Arg Asn Asp Ala Gln Pro 
            100                 105                 110         


Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly Ser 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser Cys 
            180                 185                 190         


Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe Gln 
        195                 200                 205             


Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215     


<210>  53
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric Clone B variable HC and canine IgG-B with 
       leader sequence

<400>  53

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
145                 150                 155                 160 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
        195                 200                 205             


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
225                 230                 235                 240 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
        275                 280                 285             


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
    290                 295                 300                 


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
                325                 330                 335     


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
            340                 345                 350         


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
        355                 360                 365             


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
                405                 410                 415     


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
        435                 440                 445             


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  54
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric Clone B variable LC and canine ? light 
       constant region with leader sequence

<400>  54

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile 
        35                  40                  45              


Ser Gly Tyr Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys 
    50                  55                  60                  


Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Ser 
            100                 105                 110         


Tyr Pro Trp Thr Phe Gly Gly Gly Ala Arg Leu Glu Ile Lys Arg Asn 
        115                 120                 125             


Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu 
    130                 135                 140                 


His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr 
                165                 170                 175     


Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu 
        195                 200                 205             


Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile 
    210                 215                 220                 


Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235     


<210>  55
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric Clone I variable HC and canine IgG-B 
       (Chimeric I HC)

<400>  55

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  56
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric Clone I variable LC and canine ? light 
       constant region  (Chimeric I LC)

<400>  56

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  57
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric Clone I variable HC and canine IgG-B with 
       leader sequence

<400>  57

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Thr Ala Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
145                 150                 155                 160 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
        195                 200                 205             


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
225                 230                 235                 240 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp 
        275                 280                 285             


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
    290                 295                 300                 


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
                325                 330                 335     


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
            340                 345                 350         


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
        355                 360                 365             


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
385                 390                 395                 400 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
                405                 410                 415     


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
        435                 440                 445             


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys 
465                 470 


<210>  58
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric Clone I variable LC and canine ? light 
       constant region with leader sequence

<400>  58

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu 
        35                  40                  45              


Ile Ser Gly Tyr Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala 
            100                 105                 110         


Ser Tyr Pro Trp Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
    130                 135                 140                 


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
                165                 170                 175     


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
        195                 200                 205             


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
    210                 215                 220                 


Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
225                 230                 235         


<210>  59
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone B variable HC v1

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  60
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone B variable HC v2

<400>  60

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone B variable LC v1

<400>  61

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Val Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys 
            100                 105         


<210>  62
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone B variable LC v2

<400>  62

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Asp Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Gly Val Tyr Tyr Cys Val Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  63
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable HC v1

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  64
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable HC v2

<400>  64

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable LC v1

<400>  65

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys 
            100                 105         


<210>  66
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable LC v2

<400>  66

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Asp Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Gly Val Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  67
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized Clone B variable HC

<400>  67

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Leu Arg Gln Ala Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  68
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized Clone B variable LC

<400>  68

Asp Ile Thr Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Pro Gly 
1               5                   10                  15      


Gln Gln Val Thr Met Asn Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Tyr Cys Val Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  69
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized Clone I variable HC

<400>  69

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Leu Arg Gln Ala Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  70
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized Clone I variable LC

<400>  70

Asp Ile Thr Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Pro Gly 
1               5                   10                  15      


Gln Gln Val Thr Met Asn Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  71
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone B variable HC v1 and  variant canine 
       IgG-B  C1q , CD16

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  72
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone B variable HC v2 and  variant canine 
       IgG-B  C1q , CD16

<400>  72

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  73
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone B variable LC v1 and canine ? light 
       constant region

<400>  73

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Val Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  74
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone B variable LC v2 and canine ? light 
       constant region

<400>  74

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Asp Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Gly Val Tyr Tyr Cys Val Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Leu Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  75
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable HC v1 and  variant canine 
       IgG-B  C1q , CD16

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  76
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable HC v2 and  variant canine 
       IgG-B  C1q , CD16

<400>  76

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  77
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable LC v1 and canine ? light 
       constant region

<400>  77

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  78
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable LC v2 and canine ? light 
       constant region

<400>  78

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Asp Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Gly Val Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Leu Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  79
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized Clone B variable HC and variant feline IgG2 
       with hinge Cys modification

<400>  79

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Leu Arg Gln Ala Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Ser Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Leu Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ala Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Leu Ser Asp Thr Phe Thr Cys Asn Val Ala His Arg Pro Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys 
    210                 215                 220                 


Thr Gly Glu Cys Pro Lys Cys Pro Val Pro Glu Ile Pro Gly Ala Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp 
            260                 265                 270         


Ser Asn Val Gln Ile Thr Trp Phe Val Asp Asn Thr Glu Met His Thr 
        275                 280                 285             


Ala Lys Thr Arg Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Ala Met Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Thr Gln Glu Glu Leu Ser Glu Asn Lys Val Ser Val Thr 
        355                 360                 365             


Cys Leu Ile Lys Gly Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Ser Asp Gly Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val 
                405                 410                 415     


Asp Arg Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser 
            420                 425                 430         


His Glu Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  80
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized Clone B variable HC and variant feline IgG2 
       with feline IgG1hinge

<400>  80

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Leu Arg Gln Ala Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Asn Tyr Gly Ile Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Ser Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Leu Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ala Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Leu Ser Asp Thr Phe Thr Cys Asn Val Ala His Arg Pro Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Arg Lys Thr Asp His Pro Pro Gly Pro Lys 
    210                 215                 220                 


Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp 
            260                 265                 270         


Ser Asn Val Gln Ile Thr Trp Phe Val Asp Asn Thr Glu Met His Thr 
        275                 280                 285             


Ala Lys Thr Arg Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Ala Met Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Thr Gln Glu Glu Leu Ser Glu Asn Lys Val Ser Val Thr 
        355                 360                 365             


Cys Leu Ile Lys Gly Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Ser Asp Gly Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val 
                405                 410                 415     


Asp Arg Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser 
            420                 425                 430         


His Glu Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  81
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized Clone B variable LC and feline  ? light 
       constant region

<400>  81

Asp Ile Thr Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Pro Gly 
1               5                   10                  15      


Gln Gln Val Thr Met Asn Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Tyr Cys Val Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Ala Gln 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr Pro Lys Glu Val 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Asn Lys Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln Ser His Glu Lys Phe 
            180                 185                 190         


Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr Leu Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Ser Glu Cys Gln Arg Glu 
    210                 215         


<210>  82
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized Clone I variable HC and variant feline IgG2 
       with hinge Cys modification

<400>  82

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Leu Arg Gln Ala Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Ser Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Leu Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ala Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Leu Ser Asp Thr Phe Thr Cys Asn Val Ala His Arg Pro Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys 
    210                 215                 220                 


Thr Gly Glu Cys Pro Lys Cys Pro Val Pro Glu Ile Pro Gly Ala Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp 
            260                 265                 270         


Ser Asn Val Gln Ile Thr Trp Phe Val Asp Asn Thr Glu Met His Thr 
        275                 280                 285             


Ala Lys Thr Arg Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Ala Met Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Thr Gln Glu Glu Leu Ser Glu Asn Lys Val Ser Val Thr 
        355                 360                 365             


Cys Leu Ile Lys Gly Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Ser Asp Gly Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val 
                405                 410                 415     


Asp Arg Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser 
            420                 425                 430         


His Glu Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  83
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized Clone I variable HC and variant feline IgG2 
       with feline IgG1 hinge

<400>  83

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Leu Arg Gln Ala Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Ser Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Leu Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ala Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Leu Ser Asp Thr Phe Thr Cys Asn Val Ala His Arg Pro Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Arg Lys Thr Asp His Pro Pro Gly Pro Lys 
    210                 215                 220                 


Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp 
            260                 265                 270         


Ser Asn Val Gln Ile Thr Trp Phe Val Asp Asn Thr Glu Met His Thr 
        275                 280                 285             


Ala Lys Thr Arg Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Ala Met Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Thr Gln Glu Glu Leu Ser Glu Asn Lys Val Ser Val Thr 
        355                 360                 365             


Cys Leu Ile Lys Gly Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Ser Asp Gly Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val 
                405                 410                 415     


Asp Arg Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser 
            420                 425                 430         


His Glu Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  84
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized Clone I variable LC and feline  ? light 
       constant region

<400>  84

Asp Ile Thr Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Pro Gly 
1               5                   10                  15      


Gln Gln Val Thr Met Asn Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Ala Gln 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr Pro Lys Glu Val 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Asn Lys Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln Ser His Glu Lys Phe 
            180                 185                 190         


Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr Leu Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Ser Glu Cys Gln Arg Glu 
    210                 215         


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: IL4R epitope 1 (minimal sequence)


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X is D or N

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X is H or R

<400>  85

Leu Xaa Phe Met Gly Ser Glu Asn Xaa Thr 
1               5                   10  


<210>  86
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: IL4R epitope 1 (expanded sequence)


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X is D or N

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  X is H or R

<400>  86

Arg Leu Ser Tyr Gln Leu Xaa Phe Met Gly Ser Glu Asn Xaa Thr Cys 
1               5                   10                  15      


Val Pro Glu Asn 
            20  


<210>  87
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: IL4R epitope 2


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is P or L

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is I or M

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X is A or F

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  X is D or H

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  X is Q or T

<400>  87

Ser Met Xaa Xaa Asp Asp Xaa Val Glu Ala Asp Val Tyr Gln Leu Xaa 
1               5                   10                  15      


Leu Trp Ala Gly Xaa Gln 
            20          


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R epitope 1 (minimal sequence)

<400>  88

Leu Asp Phe Met Gly Ser Glu Asn His Thr 
1               5                   10  


<210>  89
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R epitope 1 (expanded sequence)

<400>  89

Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn His Thr Cys 
1               5                   10                  15      


Val Pro Glu Asn 
            20  


<210>  90
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R epitope 2

<400>  90

Ser Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp 
1               5                   10                  15      


Leu Trp Ala Gly Gln Gln 
            20          


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Feline IL4R epitope 1 (minimal sequence)

<400>  91

Leu Asn Phe Met Gly Ser Glu Asn Arg Thr 
1               5                   10  


<210>  92
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Feline IL4R epitope 1 (expanded sequence)

<400>  92

Arg Leu Ser Tyr Gln Leu Asn Phe Met Gly Ser Glu Asn Arg Thr Cys 
1               5                   10                  15      


Val Pro Glu Asn 
            20  


<210>  93
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Feline IL4R epitope 2

<400>  93

Ser Met Leu Met Asp Asp Phe Val Glu Ala Asp Val Tyr Gln Leu His 
1               5                   10                  15      


Leu Trp Ala Gly Thr Gln 
            20          


<210>  94
<211>  823
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<222>  (1)..(823)
<223>  Canine IL4R

<400>  94

Met Gly Arg Leu Cys Ser Gly Leu Thr Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Val Trp Val Ala Ser Ser Gly Ser Val Lys Val Leu His Glu Pro 
            20                  25                  30          


Ser Cys Phe Ser Asp Tyr Ile Ser Thr Ser Val Cys Gln Trp Lys Met 
        35                  40                  45              


Asp His Pro Thr Asn Cys Ser Ala Glu Leu Arg Leu Ser Tyr Gln Leu 
    50                  55                  60                  


Asp Phe Met Gly Ser Glu Asn His Thr Cys Val Pro Glu Asn Arg Glu 
65                  70                  75                  80  


Asp Ser Val Cys Val Cys Ser Met Pro Ile Asp Asp Ala Val Glu Ala 
                85                  90                  95      


Asp Val Tyr Gln Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Ser 
            100                 105                 110         


Gly Ser Phe Gln Pro Ser Lys His Val Lys Pro Arg Thr Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Ser His Thr Trp Leu Leu Met Trp Thr 
    130                 135                 140                 


Asn Pro Tyr Pro Thr Glu Asn His Leu His Ser Glu Leu Thr Tyr Met 
145                 150                 155                 160 


Val Asn Val Ser Asn Asp Asn Asp Pro Glu Asp Phe Lys Val Tyr Asn 
                165                 170                 175     


Val Thr Tyr Met Gly Pro Thr Leu Arg Leu Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ala Ser Tyr Ser Ala Arg Val Arg Ala Trp Ala Gln Thr Tyr 
        195                 200                 205             


Asn Ser Thr Trp Ser Asp Trp Ser Pro Ser Thr Thr Trp Leu Asn Tyr 
    210                 215                 220                 


Tyr Glu Pro Trp Glu Gln His Leu Pro Leu Gly Val Ser Ile Ser Cys 
225                 230                 235                 240 


Leu Val Ile Leu Ala Ile Cys Leu Ser Cys Tyr Phe Ser Ile Ile Lys 
                245                 250                 255     


Ile Lys Lys Gly Trp Trp Asp Gln Ile Pro Asn Pro Ala His Ser Pro 
            260                 265                 270         


Leu Val Ala Ile Val Ile Gln Asp Ser Gln Val Ser Leu Trp Gly Lys 
        275                 280                 285             


Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Thr Cys 
    290                 295                 300                 


Leu Thr Lys Leu Leu Pro Cys Leu Leu Glu His Gly Leu Gly Arg Glu 
305                 310                 315                 320 


Glu Glu Ser Pro Lys Thr Ala Lys Asn Gly Pro Leu Gln Gly Pro Gly 
                325                 330                 335     


Lys Pro Ala Trp Cys Pro Val Glu Val Ser Lys Thr Ile Leu Trp Pro 
            340                 345                 350         


Glu Ser Ile Ser Val Val Gln Cys Val Glu Leu Ser Glu Ala Pro Val 
        355                 360                 365             


Asp Asn Glu Glu Glu Glu Glu Val Glu Glu Asp Lys Arg Ser Leu Cys 
    370                 375                 380                 


Pro Ser Leu Glu Gly Ser Gly Gly Ser Phe Gln Glu Gly Arg Glu Gly 
385                 390                 395                 400 


Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly Gly 
                405                 410                 415     


Glu Asn Gly Gly Phe Cys Pro Gln Gly Leu Glu Glu Ser Cys Leu Pro 
            420                 425                 430         


Pro Pro Ser Gly Ser Val Gly Ala Gln Met Pro Trp Ala Gln Phe Pro 
        435                 440                 445             


Arg Ala Gly Pro Arg Ala Ala Pro Glu Gly Pro Glu Gln Pro Arg Arg 
    450                 455                 460                 


Pro Glu Ser Ala Leu Gln Ala Ser Pro Thr Gln Ser Ala Gly Ser Ser 
465                 470                 475                 480 


Ala Phe Pro Glu Pro Pro Pro Val Val Thr Asp Asn Pro Ala Tyr Arg 
                485                 490                 495     


Ser Phe Gly Ser Phe Leu Gly Gln Ser Ser Asp Pro Gly Asp Gly Asp 
            500                 505                 510         


Ser Asp Pro Glu Leu Ala Asp Arg Pro Gly Glu Ala Asp Pro Gly Ile 
        515                 520                 525             


Pro Ser Ala Pro Gln Pro Pro Glu Pro Pro Ala Ala Leu Gln Pro Glu 
    530                 535                 540                 


Pro Glu Ser Trp Glu Gln Ile Leu Arg Gln Ser Val Leu Gln His Arg 
545                 550                 555                 560 


Ala Ala Pro Ala Pro Gly Pro Gly Pro Gly Ser Gly Tyr Arg Glu Phe 
                565                 570                 575     


Thr Cys Ala Val Lys Gln Gly Ser Ala Pro Asp Ala Gly Gly Pro Gly 
            580                 585                 590         


Phe Gly Pro Ser Gly Glu Ala Gly Tyr Lys Ala Phe Cys Ser Leu Leu 
        595                 600                 605             


Pro Gly Gly Ala Thr Cys Pro Gly Thr Ser Gly Gly Glu Ala Gly Ser 
    610                 615                 620                 


Gly Glu Gly Gly Tyr Lys Pro Phe Gln Ser Leu Thr Pro Gly Cys Pro 
625                 630                 635                 640 


Gly Ala Pro Thr Pro Val Pro Val Pro Leu Phe Thr Phe Gly Leu Asp 
                645                 650                 655     


Thr Glu Pro Pro Gly Ser Pro Gln Asp Ser Leu Gly Ala Gly Ser Ser 
            660                 665                 670         


Pro Glu His Leu Gly Val Glu Pro Ala Gly Lys Glu Glu Asp Ser Arg 
        675                 680                 685             


Lys Thr Leu Leu Ala Pro Glu Gln Ala Thr Asp Pro Leu Arg Asp Asp 
    690                 695                 700                 


Leu Ala Ser Ser Ile Val Tyr Ser Ala Leu Thr Cys His Leu Cys Gly 
705                 710                 715                 720 


His Leu Lys Gln Trp His Asp Gln Glu Glu Arg Gly Lys Ala His Ile 
                725                 730                 735     


Val Pro Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser Ser Leu 
            740                 745                 750         


Leu Leu Ser Pro Leu Arg Ala Pro Asn Val Leu Pro Gly Gly Val Leu 
        755                 760                 765             


Leu Glu Ala Ser Leu Ser Pro Ala Ser Leu Val Pro Ser Gly Val Ser 
    770                 775                 780                 


Lys Glu Gly Lys Ser Ser Pro Phe Ser Gln Pro Ala Ser Ser Ser Ala 
785                 790                 795                 800 


Gln Ser Ser Ser Gln Thr Pro Lys Lys Leu Ala Val Leu Ser Thr Glu 
                805                 810                 815     


Pro Thr Cys Met Ser Ala Ser 
            820             


<210>  95
<211>  818
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(818)
<223>  Feline IL4R

<400>  95

Met Gly Arg Leu Cys Ser Gly Leu Thr Phe Pro Val Ser Cys Leu Ile 
1               5                   10                  15      


Leu Met Trp Ala Ala Gly Ser Gly Ser Val Lys Val Leu Arg Ala Pro 
            20                  25                  30          


Thr Cys Phe Ser Asp Tyr Phe Ser Thr Ser Val Cys Gln Trp Asn Met 
        35                  40                  45              


Asp Ala Pro Thr Asn Cys Ser Ala Glu Leu Arg Leu Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Phe Met Gly Ser Glu Asn Arg Thr Cys Val Pro Glu Asn Gly Glu 
65                  70                  75                  80  


Gly Ala Ala Cys Ala Cys Ser Met Leu Met Asp Asp Phe Val Glu Ala 
                85                  90                  95      


Asp Val Tyr Gln Leu His Leu Trp Ala Gly Thr Gln Leu Leu Trp Ser 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Ser His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Pro Asn Val Ser His Thr Trp Leu Leu Arg Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Glu Asn His Leu His Ala Glu Leu Thr Tyr Met 
145                 150                 155                 160 


Val Asn Ile Ser Ser Glu Asp Asp Pro Thr Asp Ser Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Met Gly Pro Thr Leu Arg Val Ala Ala Ser Thr Leu Thr 
            180                 185                 190         


Ser Gly Ala Ser Tyr Ser Ala Arg Val Arg Ala Trp Ala Gln Ser Tyr 
        195                 200                 205             


Asn Ser Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp Leu Asn His 
    210                 215                 220                 


Tyr Glu Pro Trp Glu Gln His Leu Pro Leu Gly Val Ser Ile Ser Cys 
225                 230                 235                 240 


Leu Val Ile Leu Ala Val Cys Leu Ser Cys Tyr Leu Ser Val Ile Lys 
                245                 250                 255     


Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala His Ser His 
            260                 265                 270         


Leu Val Ala Ile Val Ile Gln Asp Pro Gln Val Ser Leu Trp Gly Lys 
        275                 280                 285             


Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Ser His Trp Lys Thr Cys 
    290                 295                 300                 


Leu Arg Lys Leu Leu Pro Cys Leu Leu Glu His Gly Met Glu Arg Lys 
305                 310                 315                 320 


Glu Asp Pro Ser Lys Ile Ala Arg Asn Gly Pro Ser Gln Gly Ser Gly 
                325                 330                 335     


Lys Ser Ala Trp Cys Pro Val Glu Val Ser Lys Thr Ile Leu Trp Pro 
            340                 345                 350         


Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Leu Glu Ala Pro Val 
        355                 360                 365             


Glu Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Lys Gly Ser Phe 
    370                 375                 380                 


Cys Pro Ser Pro Val Asn Leu Glu Asp Ser Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Ala Ala Arg Leu Thr Glu Ser Leu Phe Met Asp Leu Leu Gly 
                405                 410                 415     


Val Glu Lys Gly Gly Phe Gly Pro Gln Gly Ser Leu Glu Ser Trp Phe 
            420                 425                 430         


Pro Pro Pro Ser Gly Ser Ala Gly Ala Gln Met Pro Trp Ala Glu Phe 
        435                 440                 445             


Pro Gly Pro Gly Pro Gln Glu Ala Ser Pro Gln Gly Lys Glu Gln Pro 
    450                 455                 460                 


Phe Asp Pro Arg Ser Asp Pro Leu Ala Thr Leu Pro Gln Ser Pro Ala 
465                 470                 475                 480 


Ser Pro Thr Phe Pro Glu Thr Pro Pro Val Val Thr Asp Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Gly Thr Phe Gln Gly Arg Ser Ser Gly Pro Gly Glu 
            500                 505                 510         


Cys Asp Ser Gly Pro Glu Leu Ala Gly Arg Leu Gly Glu Ala Asp Pro 
        515                 520                 525             


Gly Ile Pro Ala Ala Pro Gln Pro Ser Glu Pro Pro Ser Ala Leu Gln 
    530                 535                 540                 


Pro Glu Ala Glu Thr Trp Glu Gln Ile Leu Arg Gln Arg Val Leu Gln 
545                 550                 555                 560 


His Arg Gly Ala Pro Ala Pro Ala Pro Gly Ser Gly Tyr Arg Glu Phe 
                565                 570                 575     


Val Cys Ala Val Arg Gln Gly Ser Thr Gln Asp Ser Arg Val Gly Asp 
            580                 585                 590         


Phe Gly Pro Ser Glu Glu Ala Gly Tyr Lys Ala Phe Ser Ser Leu Leu 
        595                 600                 605             


Thr Ser Gly Ala Val Cys Pro Glu Thr Ser Gly Gly Glu Ala Gly Ser 
    610                 615                 620                 


Gly Asp Gly Gly Tyr Lys Pro Phe Gln Ser Leu Thr Pro Gly Cys Pro 
625                 630                 635                 640 


Gly Ala Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly Leu Asp 
                645                 650                 655     


Ala Glu Pro Pro His Cys Pro Gln Asp Ser Pro Leu Pro Gly Ser Ser 
            660                 665                 670         


Pro Glu Pro Ala Gly Lys Ala Gln Asp Ser His Lys Thr Pro Pro Ala 
        675                 680                 685             


Pro Glu Gln Ala Ala Asp Pro Leu Arg Asp Asp Leu Ala Ser Gly Ile 
    690                 695                 700                 


Val Tyr Ser Ala Leu Thr Cys His Leu Cys Gly His Leu Lys Gln Cys 
705                 710                 715                 720 


His Gly Gln Glu Glu Gly Gly Glu Ala His Pro Val Ala Ser Pro Cys 
                725                 730                 735     


Cys Gly Cys Cys Cys Gly Asp Arg Ser Ser Pro Leu Val Ser Pro Leu 
            740                 745                 750         


Arg Ala Pro Asp Pro Leu Pro Gly Gly Val Pro Leu Glu Ala Ser Leu 
        755                 760                 765             


Ser Pro Ala Ser Pro Ala Pro Leu Ala Val Ser Glu Glu Gly Pro Pro 
    770                 775                 780                 


Ser Leu Cys Phe Gln Pro Ala Leu Ser His Ala His Ser Ser Ser Gln 
785                 790                 795                 800 


Thr Pro Lys Lys Val Ala Met Leu Ser Pro Glu Pro Thr Cys Thr Met 
                805                 810                 815     


Ala Ser 
        


<210>  96
<211>  809
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<222>  (1)..(809)
<223>  Equine IL4R

<400>  96

Met Gly Cys Leu Cys Pro Gly Leu Thr Leu Pro Val Ser Cys Leu Ile 
1               5                   10                  15      


Leu Val Trp Ala Ala Gly Ser Gly Ser Val Lys Val Leu Arg Leu Thr 
            20                  25                  30          


Ala Cys Phe Ser Asp Tyr Ile Ser Ala Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asp Arg Pro Thr Asn Cys Ser Ala Gln Leu Arg Leu Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Asp Glu Phe Ser Asp Asn Leu Thr Cys Ile Pro Glu Asn Arg Glu 
65                  70                  75                  80  


Asp Glu Val Cys Val Cys Arg Met Leu Met Asp Asn Ile Val Ser Glu 
                85                  90                  95      


Asp Val Tyr Glu Leu Asp Leu Trp Ala Gly Asn Gln Leu Leu Trp Asn 
            100                 105                 110         


Ser Ser Phe Lys Pro Ser Arg His Val Lys Pro Arg Ala Pro Gln Asn 
        115                 120                 125             


Leu Thr Val His Ala Ile Ser His Thr Trp Leu Leu Thr Trp Ser Asn 
    130                 135                 140                 


Pro Tyr Pro Leu Lys Asn His Leu Trp Ser Glu Leu Thr Tyr Leu Val 
145                 150                 155                 160 


Asn Ile Ser Lys Glu Asp Asp Pro Thr Asp Phe Lys Ile Tyr Asn Val 
                165                 170                 175     


Thr Tyr Met Asp Pro Thr Leu Arg Val Thr Ala Ser Thr Leu Lys Ser 
            180                 185                 190         


Arg Ala Thr Tyr Ser Ala Arg Val Lys Ala Arg Ala Gln Asn Tyr Asn 
        195                 200                 205             


Ser Thr Trp Ser Glu Trp Ser Pro Ser Thr Thr Trp His Asn Tyr Tyr 
    210                 215                 220                 


Glu Gln Pro Leu Glu Gln Arg Leu Pro Leu Gly Val Ser Ile Ser Cys 
225                 230                 235                 240 


Val Val Ile Leu Ala Ile Cys Leu Ser Cys Tyr Phe Ser Ile Ile Lys 
                245                 250                 255     


Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala His Ser Pro 
            260                 265                 270         


Leu Val Ala Ile Val Leu Gln Asp Ser Gln Val Ser Leu Trp Gly Lys 
        275                 280                 285             


Gln Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro Arg Trp Lys Thr Cys 
    290                 295                 300                 


Leu Thr Lys Leu Leu Pro Cys Leu Leu Glu His Gly Leu Gln Lys Glu 
305                 310                 315                 320 


Glu Asp Ser Ser Lys Thr Val Arg Asn Gly Pro Phe Gln Ser Pro Gly 
                325                 330                 335     


Lys Ser Ala Trp His Thr Val Glu Val Asn His Thr Ile Leu Arg Pro 
            340                 345                 350         


Glu Ile Ile Ser Val Val Pro Cys Val Glu Leu Cys Glu Ala Gln Val 
        355                 360                 365             


Glu Ser Glu Glu Glu Glu Val Glu Glu Asp Arg Gly Ser Phe Cys Pro 
    370                 375                 380                 


Ser Pro Glu Ser Ser Gly Ser Gly Phe Gln Glu Gly Arg Glu Gly Val 
385                 390                 395                 400 


Ala Ala Arg Leu Thr Glu Ser Leu Phe Leu Gly Leu Leu Gly Ala Glu 
                405                 410                 415     


Asn Gly Ala Leu Gly Glu Ser Cys Leu Leu Pro Pro Leu Gly Ser Ala 
            420                 425                 430         


His Met Pro Trp Ala Arg Ile Ser Ser Ala Gly Pro Gln Glu Ala Ala 
        435                 440                 445             


Ser Gln Gly Glu Glu Gln Pro Leu Asn Pro Glu Ser Asn Pro Leu Ala 
    450                 455                 460                 


Thr Leu Thr Gln Ser Pro Gly Ser Leu Ala Phe Thr Glu Ala Pro Ala 
465                 470                 475                 480 


Val Val Ala Asp Asn Pro Ala Tyr Arg Ser Phe Ser Asn Ser Leu Ser 
                485                 490                 495     


Gln Pro Arg Gly Pro Gly Glu Leu Asp Ser Asp Pro Gln Leu Ala Glu 
            500                 505                 510         


His Leu Gly Gln Val Asp Pro Ser Ile Pro Ser Ala Pro Gln Pro Ser 
        515                 520                 525             


Glu Pro Pro Thr Ala Leu Gln Pro Glu Pro Glu Thr Trp Glu Gln Met 
    530                 535                 540                 


Leu Arg Gln Ser Val Leu Gln Gln Gly Ala Ala Pro Ala Pro Ala Ser 
545                 550                 555                 560 


Ala Pro Thr Gly Gly Tyr Arg Glu Phe Ala Gln Val Val Lys Gln Gly 
                565                 570                 575     


Gly Gly Ala Ala Gly Ser Gly Pro Ser Gly Glu Ala Gly Tyr Lys Ala 
            580                 585                 590         


Phe Ser Ser Leu Leu Ala Gly Ser Ala Val Cys Pro Gly Gln Ser Gly 
        595                 600                 605             


Val Glu Ala Ser Ser Gly Glu Gly Gly Tyr Arg Pro Tyr Glu Ser Pro 
    610                 615                 620                 


Asp Pro Gly Ala Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
625                 630                 635                 640 


Leu Asp Val Glu Pro Pro His Ser Pro Gln Asn Ser Leu Leu Pro Gly 
                645                 650                 655     


Gly Ser Pro Glu Leu Pro Gly Pro Glu Pro Thr Val Lys Gly Glu Asp 
            660                 665                 670         


Pro Arg Lys Pro Leu Leu Ser Ala Gln Gln Ala Thr Asp Ser Leu Arg 
        675                 680                 685             


Asp Asp Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
    690                 695                 700                 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Glu His Gly Glu Ala 
705                 710                 715                 720 


His Thr Val Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
                725                 730                 735     


Ser Pro Pro Val Ser Pro Val Arg Ala Leu Asp Pro Pro Pro Gly Gly 
            740                 745                 750         


Val Pro Leu Glu Ala Gly Leu Ser Leu Ala Ser Leu Gly Ser Leu Gly 
        755                 760                 765             


Leu Ser Glu Glu Arg Lys Pro Ser Leu Phe Phe Gln Pro Ala Pro Gly 
    770                 775                 780                 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Leu Thr Val Ala Met Leu Ser 
785                 790                 795                 800 


Thr Gly Pro Thr Cys Thr Ser Ala Ser 
                805                 


<210>  97
<211>  810
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(810)
<223>  Murine IL4R

<400>  97

Met Gly Arg Leu Cys Thr Lys Phe Leu Thr Ser Val Gly Cys Leu Ile 
1               5                   10                  15      


Leu Leu Leu Val Thr Gly Ser Gly Ser Ile Lys Val Leu Gly Glu Pro 
            20                  25                  30          


Thr Cys Phe Ser Asp Tyr Ile Arg Thr Ser Thr Cys Glu Trp Phe Leu 
        35                  40                  45              


Asp Ser Ala Val Asp Cys Ser Ser Gln Leu Cys Leu His Tyr Arg Leu 
    50                  55                  60                  


Met Phe Phe Glu Phe Ser Glu Asn Leu Thr Cys Ile Pro Arg Asn Ser 
65                  70                  75                  80  


Ala Ser Thr Val Cys Val Cys His Met Glu Met Asn Arg Pro Val Gln 
                85                  90                  95      


Ser Asp Arg Tyr Gln Met Glu Leu Trp Ala Glu His Arg Gln Leu Trp 
            100                 105                 110         


Gln Gly Ser Phe Ser Pro Ser Gly Asn Val Lys Pro Leu Ala Pro Asp 
        115                 120                 125             


Asn Leu Thr Leu His Thr Asn Val Ser Asp Glu Trp Leu Leu Thr Trp 
    130                 135                 140                 


Asn Asn Leu Tyr Pro Ser Asn Asn Leu Leu Tyr Lys Asp Leu Ile Ser 
145                 150                 155                 160 


Met Val Asn Ile Ser Arg Glu Asp Asn Pro Ala Glu Phe Ile Val Tyr 
                165                 170                 175     


Asn Val Thr Tyr Lys Glu Pro Arg Leu Ser Phe Pro Ile Asn Ile Leu 
            180                 185                 190         


Met Ser Gly Val Tyr Tyr Thr Ala Arg Val Arg Val Arg Ser Gln Ile 
        195                 200                 205             


Leu Thr Gly Thr Trp Ser Glu Trp Ser Pro Ser Ile Thr Trp Tyr Asn 
    210                 215                 220                 


His Phe Gln Leu Pro Leu Ile Gln Arg Leu Pro Leu Gly Val Thr Ile 
225                 230                 235                 240 


Ser Cys Leu Cys Ile Pro Leu Phe Cys Leu Phe Cys Tyr Phe Ser Ile 
                245                 250                 255     


Thr Lys Ile Lys Lys Ile Trp Trp Asp Gln Ile Pro Thr Pro Ala Arg 
            260                 265                 270         


Ser Pro Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Val Pro Leu Trp 
        275                 280                 285             


Asp Lys Gln Thr Arg Ser Gln Glu Ser Thr Lys Tyr Pro His Trp Lys 
    290                 295                 300                 


Thr Cys Leu Asp Lys Leu Leu Pro Cys Leu Leu Lys His Arg Val Lys 
305                 310                 315                 320 


Lys Lys Thr Asp Phe Pro Lys Ala Ala Pro Thr Lys Ser Leu Gln Ser 
                325                 330                 335     


Pro Gly Lys Ala Gly Trp Cys Pro Met Glu Val Ser Arg Thr Val Leu 
            340                 345                 350         


Trp Pro Glu Asn Val Ser Val Ser Val Val Arg Cys Met Glu Leu Phe 
        355                 360                 365             


Glu Ala Pro Val Gln Asn Val Glu Glu Glu Glu Asp Glu Ile Val Lys 
    370                 375                 380                 


Glu Asp Leu Ser Met Ser Pro Glu Asn Ser Gly Gly Cys Gly Phe Gln 
385                 390                 395                 400 


Glu Ser Gln Ala Asp Ile Met Ala Arg Leu Thr Glu Asn Leu Phe Ser 
                405                 410                 415     


Asp Leu Leu Glu Ala Glu Asn Gly Gly Leu Gly Gln Ser Ala Leu Ala 
            420                 425                 430         


Glu Ser Cys Ser Pro Leu Pro Ser Gly Ser Gly Gln Ala Ser Val Ser 
        435                 440                 445             


Trp Ala Cys Leu Pro Met Gly Pro Ser Glu Glu Ala Thr Cys Gln Val 
    450                 455                 460                 


Thr Glu Gln Pro Ser His Pro Gly Pro Leu Ser Gly Ser Pro Ala Gln 
465                 470                 475                 480 


Ser Ala Pro Thr Leu Ala Cys Thr Gln Val Pro Leu Val Leu Ala Asp 
                485                 490                 495     


Asn Pro Ala Tyr Arg Ser Phe Ser Asp Cys Cys Ser Pro Ala Pro Asn 
            500                 505                 510         


Pro Gly Glu Leu Ala Pro Glu Gln Gln Gln Ala Asp His Leu Glu Glu 
        515                 520                 525             


Glu Glu Pro Pro Ser Pro Ala Asp Pro His Ser Ser Gly Pro Pro Met 
    530                 535                 540                 


Gln Pro Val Glu Ser Trp Glu Gln Ile Leu His Met Ser Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Gly Ser Thr Pro Ala Pro Ala Gly Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val Gln Ala Val Lys Gln Gly Ala Ala Gln Asp Pro Gly Val 
            580                 585                 590         


Pro Gly Val Arg Pro Ser Gly Asp Pro Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ser Ser Asn Gly Ile Arg Gly Asp Thr Ala Ala Ala Gly Thr 
    610                 615                 620                 


Asp Asp Gly His Gly Gly Tyr Lys Pro Phe Gln Asn Pro Val Pro Asn 
625                 630                 635                 640 


Gln Ser Pro Ser Ser Val Pro Leu Phe Thr Phe Gly Leu Asp Thr Glu 
                645                 650                 655     


Leu Ser Pro Ser Pro Leu Asn Ser Asp Pro Pro Lys Ser Pro Pro Glu 
            660                 665                 670         


Cys Leu Gly Leu Glu Leu Gly Leu Lys Gly Gly Asp Trp Val Lys Ala 
        675                 680                 685             


Pro Pro Pro Ala Asp Gln Val Pro Lys Pro Phe Gly Asp Asp Leu Gly 
    690                 695                 700                 


Phe Gly Ile Val Tyr Ser Ser Leu Thr Cys His Leu Cys Gly His Leu 
705                 710                 715                 720 


Lys Gln His His Ser Gln Glu Glu Gly Gly Gln Ser Pro Ile Val Ala 
                725                 730                 735     


Ser Pro Gly Cys Gly Cys Cys Tyr Asp Asp Arg Ser Pro Ser Leu Gly 
            740                 745                 750         


Ser Leu Ser Gly Ala Leu Glu Ser Cys Pro Glu Gly Ile Pro Pro Glu 
        755                 760                 765             


Ala Asn Leu Met Ser Ala Pro Lys Thr Pro Ser Asn Leu Ser Gly Glu 
    770                 775                 780                 


Gly Lys Gly Pro Gly His Ser Pro Val Pro Ser Gln Thr Thr Glu Val 
785                 790                 795                 800 


Pro Val Gly Ala Leu Gly Ile Ala Val Ser 
                805                 810 


<210>  98
<211>  825
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(825)
<223>  Human IL4R

<400>  98

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  99
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R_ECD

<400>  99

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu 
        195                 200             


<210>  100
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Feline IL4R_ECD

<400>  100

Gly Ser Val Lys Val Leu Arg Ala Pro Thr Cys Phe Ser Asp Tyr Phe 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Asn Met Asp Ala Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asn Phe Met Gly Ser Glu Asn 
        35                  40                  45              


Arg Thr Cys Val Pro Glu Asn Gly Glu Gly Ala Ala Cys Ala Cys Ser 
    50                  55                  60                  


Met Leu Met Asp Asp Phe Val Glu Ala Asp Val Tyr Gln Leu His Leu 
65                  70                  75                  80  


Trp Ala Gly Thr Gln Leu Leu Trp Ser Gly Ser Phe Lys Pro Ser Ser 
                85                  90                  95      


His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Pro Asn Val 
            100                 105                 110         


Ser His Thr Trp Leu Leu Arg Trp Ser Asn Pro Tyr Pro Pro Glu Asn 
        115                 120                 125             


His Leu His Ala Glu Leu Thr Tyr Met Val Asn Ile Ser Ser Glu Asp 
    130                 135                 140                 


Asp Pro Thr Asp Ser Arg Ile Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Val Ala Ala Ser Thr Leu Thr Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Ser Tyr Asn Ser Thr Trp Ser Glu Trp 
            180                 185                 190         


Ser Pro Ser Thr Lys Trp Leu Asn His Tyr Glu 
        195                 200             


<210>  101
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Equine IL4R_ECD

<400>  101

Val Lys Val Leu Arg Leu Thr Ala Cys Phe Ser Asp Tyr Ile Ser Ala 
1               5                   10                  15      


Ser Thr Cys Glu Trp Lys Met Asp Arg Pro Thr Asn Cys Ser Ala Gln 
            20                  25                  30          


Leu Arg Leu Ser Tyr Gln Leu Asn Asp Glu Phe Ser Asp Asn Leu Thr 
        35                  40                  45              


Cys Ile Pro Glu Asn Arg Glu Asp Glu Val Cys Val Cys Arg Met Leu 
    50                  55                  60                  


Met Asp Asn Ile Val Ser Glu Asp Val Tyr Glu Leu Asp Leu Trp Ala 
65                  70                  75                  80  


Gly Asn Gln Leu Leu Trp Asn Ser Ser Phe Lys Pro Ser Arg His Val 
                85                  90                  95      


Lys Pro Arg Ala Pro Gln Asn Leu Thr Val His Ala Ile Ser His Thr 
            100                 105                 110         


Trp Leu Leu Thr Trp Ser Asn Pro Tyr Pro Leu Lys Asn His Leu Trp 
        115                 120                 125             


Ser Glu Leu Thr Tyr Leu Val Asn Ile Ser Lys Glu Asp Asp Pro Thr 
    130                 135                 140                 


Asp Phe Lys Ile Tyr Asn Val Thr Tyr Met Asp Pro Thr Leu Arg Val 
145                 150                 155                 160 


Thr Ala Ser Thr Leu Lys Ser Arg Ala Thr Tyr Ser Ala Arg Val Lys 
                165                 170                 175     


Ala Arg Ala Gln Asn Tyr Asn Ser Thr Trp Ser Glu Trp Ser Pro Ser 
            180                 185                 190         


Thr Thr Trp His Asn Tyr Tyr Glu Gln Pro Leu Glu Gln Arg 
        195                 200                 205     


<210>  102
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Murine IL4R_ECD

<400>  102

Ile Lys Val Leu Gly Glu Pro Thr Cys Phe Ser Asp Tyr Ile Arg Thr 
1               5                   10                  15      


Ser Thr Cys Glu Trp Phe Leu Asp Ser Ala Val Asp Cys Ser Ser Gln 
            20                  25                  30          


Leu Cys Leu His Tyr Arg Leu Met Phe Phe Glu Phe Ser Glu Asn Leu 
        35                  40                  45              


Thr Cys Ile Pro Arg Asn Ser Ala Ser Thr Val Cys Val Cys His Met 
    50                  55                  60                  


Glu Met Asn Arg Pro Val Gln Ser Asp Arg Tyr Gln Met Glu Leu Trp 
65                  70                  75                  80  


Ala Glu His Arg Gln Leu Trp Gln Gly Ser Phe Ser Pro Ser Gly Asn 
                85                  90                  95      


Val Lys Pro Leu Ala Pro Asp Asn Leu Thr Leu His Thr Asn Val Ser 
            100                 105                 110         


Asp Glu Trp Leu Leu Thr Trp Asn Asn Leu Tyr Pro Ser Asn Asn Leu 
        115                 120                 125             


Leu Tyr Lys Asp Leu Ile Ser Met Val Asn Ile Ser Arg Glu Asp Asn 
    130                 135                 140                 


Pro Ala Glu Phe Ile Val Tyr Asn Val Thr Tyr Lys Glu Pro Arg Leu 
145                 150                 155                 160 


Ser Phe Pro Ile Asn Ile Leu Met Ser Gly Val Tyr Tyr Thr Ala Arg 
                165                 170                 175     


Val Arg Val Arg Ser Gln Ile Leu Thr Gly Thr Trp Ser Glu Trp Ser 
            180                 185                 190         


Pro Ser Ile Thr Trp Tyr Asn His Phe Gln Leu Pro Leu Ile Gln Arg 
        195                 200                 205             


Leu Pro Leu Gly Val Thr Ile Ser Cys Leu Cys Ile Pro Leu Phe Cys 
    210                 215                 220                 


Leu Phe Cys Tyr Phe Ser Ile Thr Lys Ile Lys Lys Ile Trp 
225                 230                 235             


<210>  103
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human IL4R_ECD

<400>  103

Gly Asn Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met 
1               5                   10                  15      


Ser Ile Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser 
            20                  25                  30          


Thr Glu Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala 
        35                  40                  45              


His Thr Cys Ile Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His 
    50                  55                  60                  


Leu Leu Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Glu 
                85                  90                  95      


His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn Val 
            100                 105                 110         


Ser Asp Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn 
        115                 120                 125             


Tyr Leu Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn 
    130                 135                 140                 


Asp Pro Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser 
145                 150                 155                 160 


Leu Arg Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Cys Tyr Asn Thr Thr Trp Ser Glu Trp 
            180                 185                 190         


Ser Pro Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu Gln 
        195                 200                 205             


His 
    


<210>  104
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R_C-FLAG with leader

<400>  104

Met Gly Arg Leu Cys Ser Gly Leu Thr Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Val Trp Val Ala Ser Ser Gly Ser Val Lys Val Leu His Glu Pro 
            20                  25                  30          


Ser Cys Phe Ser Asp Tyr Ile Ser Thr Ser Val Cys Gln Trp Lys Met 
        35                  40                  45              


Asp His Pro Thr Asn Cys Ser Ala Glu Leu Arg Leu Ser Tyr Gln Leu 
    50                  55                  60                  


Asp Phe Met Gly Ser Glu Asn His Thr Cys Val Pro Glu Asn Arg Glu 
65                  70                  75                  80  


Asp Ser Val Cys Val Cys Ser Met Pro Ile Asp Asp Ala Val Glu Ala 
                85                  90                  95      


Asp Val Tyr Gln Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Ser 
            100                 105                 110         


Gly Ser Phe Gln Pro Ser Lys His Val Lys Pro Arg Thr Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Ser His Thr Trp Leu Leu Met Trp Thr 
    130                 135                 140                 


Asn Pro Tyr Pro Thr Glu Asn His Leu His Ser Glu Leu Thr Tyr Met 
145                 150                 155                 160 


Val Asn Val Ser Asn Asp Asn Asp Pro Glu Asp Phe Lys Val Tyr Asn 
                165                 170                 175     


Val Thr Tyr Met Gly Pro Thr Leu Arg Leu Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ala Ser Tyr Ser Ala Arg Val Arg Ala Trp Ala Gln Thr Tyr 
        195                 200                 205             


Asn Ser Thr Trp Ser Asp Trp Ser Pro Ser Thr Thr Trp Leu Asn Tyr 
    210                 215                 220                 


Tyr Glu Pro Trp Glu Gln His Leu Pro Leu Gly Val Ser Ile Ser Cys 
225                 230                 235                 240 


Leu Val Ile Leu Ala Ile Cys Leu Ser Cys Tyr Phe Ser Ile Ile Lys 
                245                 250                 255     


Ile Lys Lys Gly Trp Trp Asp Gln Ile Pro Asn Pro Ala His Ser Pro 
            260                 265                 270         


Leu Val Ala Ile Val Ile Gln Asp Ser Gln Val Ser Leu Trp Gly Lys 
        275                 280                 285             


Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Thr Cys 
    290                 295                 300                 


Leu Thr Lys Leu Leu Pro Cys Leu Leu Glu His Gly Leu Gly Arg Glu 
305                 310                 315                 320 


Glu Glu Ser Pro Lys Thr Ala Lys Asn Gly Pro Leu Gln Gly Pro Gly 
                325                 330                 335     


Lys Pro Ala Trp Cys Pro Val Glu Val Ser Lys Thr Ile Leu Trp Pro 
            340                 345                 350         


Glu Ser Ile Ser Val Val Gln Cys Val Glu Leu Ser Glu Ala Pro Val 
        355                 360                 365             


Asp Asn Glu Glu Glu Glu Glu Val Glu Glu Asp Lys Arg Ser Leu Cys 
    370                 375                 380                 


Pro Ser Leu Glu Gly Ser Gly Gly Ser Phe Gln Glu Gly Arg Glu Gly 
385                 390                 395                 400 


Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly Gly 
                405                 410                 415     


Glu Asn Gly Gly Phe Cys Pro Gln Gly Leu Glu Glu Ser Cys Leu Pro 
            420                 425                 430         


Pro Pro Ser Gly Ser Val Gly Ala Gln Met Pro Trp Ala Gln Phe Pro 
        435                 440                 445             


Arg Ala Gly Pro Arg Ala Ala Pro Glu Gly Pro Glu Gln Pro Arg Arg 
    450                 455                 460                 


Pro Glu Ser Ala Leu Gln Ala Ser Pro Thr Gln Ser Ala Gly Ser Ser 
465                 470                 475                 480 


Ala Phe Pro Glu Pro Pro Pro Val Val Thr Asp Asn Pro Ala Tyr Arg 
                485                 490                 495     


Ser Phe Gly Ser Phe Leu Gly Gln Ser Ser Asp Pro Gly Asp Gly Asp 
            500                 505                 510         


Ser Asp Pro Glu Leu Ala Asp Arg Pro Gly Glu Ala Asp Pro Gly Ile 
        515                 520                 525             


Pro Ser Ala Pro Gln Pro Pro Glu Pro Pro Ala Ala Leu Gln Pro Glu 
    530                 535                 540                 


Pro Glu Ser Trp Glu Gln Ile Leu Arg Gln Ser Val Leu Gln His Arg 
545                 550                 555                 560 


Ala Ala Pro Ala Pro Gly Pro Gly Pro Gly Ser Gly Tyr Arg Glu Phe 
                565                 570                 575     


Thr Cys Ala Val Lys Gln Gly Ser Ala Pro Asp Ala Gly Gly Pro Gly 
            580                 585                 590         


Phe Gly Pro Ser Gly Glu Ala Gly Tyr Lys Ala Phe Cys Ser Leu Leu 
        595                 600                 605             


Pro Gly Gly Ala Thr Cys Pro Gly Thr Ser Gly Gly Glu Ala Gly Ser 
    610                 615                 620                 


Gly Glu Gly Gly Tyr Lys Pro Phe Gln Ser Leu Thr Pro Gly Cys Pro 
625                 630                 635                 640 


Gly Ala Pro Thr Pro Val Pro Val Pro Leu Phe Thr Phe Gly Leu Asp 
                645                 650                 655     


Thr Glu Pro Pro Gly Ser Pro Gln Asp Ser Leu Gly Ala Gly Ser Ser 
            660                 665                 670         


Pro Glu His Leu Gly Val Glu Pro Ala Gly Lys Glu Glu Asp Ser Arg 
        675                 680                 685             


Lys Thr Leu Leu Ala Pro Glu Gln Ala Thr Asp Pro Leu Arg Asp Asp 
    690                 695                 700                 


Leu Ala Ser Ser Ile Val Tyr Ser Ala Leu Thr Cys His Leu Cys Gly 
705                 710                 715                 720 


His Leu Lys Gln Trp His Asp Gln Glu Glu Arg Gly Lys Ala His Ile 
                725                 730                 735     


Val Pro Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser Ser Leu 
            740                 745                 750         


Leu Leu Ser Pro Leu Arg Ala Pro Asn Val Leu Pro Gly Gly Val Leu 
        755                 760                 765             


Leu Glu Ala Ser Leu Ser Pro Ala Ser Leu Val Pro Ser Gly Val Ser 
    770                 775                 780                 


Lys Glu Gly Lys Ser Ser Pro Phe Ser Gln Pro Ala Ser Ser Ser Ala 
785                 790                 795                 800 


Gln Ser Ser Ser Gln Thr Pro Lys Lys Leu Ala Val Leu Ser Thr Glu 
                805                 810                 815     


Pro Thr Cys Met Ser Ala Ser Gly Ser Gly Ser Asp Tyr Lys Asp Asp 
            820                 825                 830         


Asp Asp Lys 
        835 


<210>  105
<211>  812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R_C-FLAG

<400>  105

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Trp Glu Gln His 
        195                 200                 205             


Leu Pro Leu Gly Val Ser Ile Ser Cys Leu Val Ile Leu Ala Ile Cys 
    210                 215                 220                 


Leu Ser Cys Tyr Phe Ser Ile Ile Lys Ile Lys Lys Gly Trp Trp Asp 
225                 230                 235                 240 


Gln Ile Pro Asn Pro Ala His Ser Pro Leu Val Ala Ile Val Ile Gln 
                245                 250                 255     


Asp Ser Gln Val Ser Leu Trp Gly Lys Arg Ser Arg Gly Gln Glu Pro 
            260                 265                 270         


Ala Lys Cys Pro His Trp Lys Thr Cys Leu Thr Lys Leu Leu Pro Cys 
        275                 280                 285             


Leu Leu Glu His Gly Leu Gly Arg Glu Glu Glu Ser Pro Lys Thr Ala 
    290                 295                 300                 


Lys Asn Gly Pro Leu Gln Gly Pro Gly Lys Pro Ala Trp Cys Pro Val 
305                 310                 315                 320 


Glu Val Ser Lys Thr Ile Leu Trp Pro Glu Ser Ile Ser Val Val Gln 
                325                 330                 335     


Cys Val Glu Leu Ser Glu Ala Pro Val Asp Asn Glu Glu Glu Glu Glu 
            340                 345                 350         


Val Glu Glu Asp Lys Arg Ser Leu Cys Pro Ser Leu Glu Gly Ser Gly 
        355                 360                 365             


Gly Ser Phe Gln Glu Gly Arg Glu Gly Ile Val Ala Arg Leu Thr Glu 
    370                 375                 380                 


Ser Leu Phe Leu Asp Leu Leu Gly Gly Glu Asn Gly Gly Phe Cys Pro 
385                 390                 395                 400 


Gln Gly Leu Glu Glu Ser Cys Leu Pro Pro Pro Ser Gly Ser Val Gly 
                405                 410                 415     


Ala Gln Met Pro Trp Ala Gln Phe Pro Arg Ala Gly Pro Arg Ala Ala 
            420                 425                 430         


Pro Glu Gly Pro Glu Gln Pro Arg Arg Pro Glu Ser Ala Leu Gln Ala 
        435                 440                 445             


Ser Pro Thr Gln Ser Ala Gly Ser Ser Ala Phe Pro Glu Pro Pro Pro 
    450                 455                 460                 


Val Val Thr Asp Asn Pro Ala Tyr Arg Ser Phe Gly Ser Phe Leu Gly 
465                 470                 475                 480 


Gln Ser Ser Asp Pro Gly Asp Gly Asp Ser Asp Pro Glu Leu Ala Asp 
                485                 490                 495     


Arg Pro Gly Glu Ala Asp Pro Gly Ile Pro Ser Ala Pro Gln Pro Pro 
            500                 505                 510         


Glu Pro Pro Ala Ala Leu Gln Pro Glu Pro Glu Ser Trp Glu Gln Ile 
        515                 520                 525             


Leu Arg Gln Ser Val Leu Gln His Arg Ala Ala Pro Ala Pro Gly Pro 
    530                 535                 540                 


Gly Pro Gly Ser Gly Tyr Arg Glu Phe Thr Cys Ala Val Lys Gln Gly 
545                 550                 555                 560 


Ser Ala Pro Asp Ala Gly Gly Pro Gly Phe Gly Pro Ser Gly Glu Ala 
                565                 570                 575     


Gly Tyr Lys Ala Phe Cys Ser Leu Leu Pro Gly Gly Ala Thr Cys Pro 
            580                 585                 590         


Gly Thr Ser Gly Gly Glu Ala Gly Ser Gly Glu Gly Gly Tyr Lys Pro 
        595                 600                 605             


Phe Gln Ser Leu Thr Pro Gly Cys Pro Gly Ala Pro Thr Pro Val Pro 
    610                 615                 620                 


Val Pro Leu Phe Thr Phe Gly Leu Asp Thr Glu Pro Pro Gly Ser Pro 
625                 630                 635                 640 


Gln Asp Ser Leu Gly Ala Gly Ser Ser Pro Glu His Leu Gly Val Glu 
                645                 650                 655     


Pro Ala Gly Lys Glu Glu Asp Ser Arg Lys Thr Leu Leu Ala Pro Glu 
            660                 665                 670         


Gln Ala Thr Asp Pro Leu Arg Asp Asp Leu Ala Ser Ser Ile Val Tyr 
        675                 680                 685             


Ser Ala Leu Thr Cys His Leu Cys Gly His Leu Lys Gln Trp His Asp 
    690                 695                 700                 


Gln Glu Glu Arg Gly Lys Ala His Ile Val Pro Ser Pro Cys Cys Gly 
705                 710                 715                 720 


Cys Cys Cys Gly Asp Arg Ser Ser Leu Leu Leu Ser Pro Leu Arg Ala 
                725                 730                 735     


Pro Asn Val Leu Pro Gly Gly Val Leu Leu Glu Ala Ser Leu Ser Pro 
            740                 745                 750         


Ala Ser Leu Val Pro Ser Gly Val Ser Lys Glu Gly Lys Ser Ser Pro 
        755                 760                 765             


Phe Ser Gln Pro Ala Ser Ser Ser Ala Gln Ser Ser Ser Gln Thr Pro 
    770                 775                 780                 


Lys Lys Leu Ala Val Leu Ser Thr Glu Pro Thr Cys Met Ser Ala Ser 
785                 790                 795                 800 


Gly Ser Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
                805                 810         


<210>  106
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_C-His6 with leader

<400>  106

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Gly Ser Val Lys Val Leu His Glu Pro 
            20                  25                  30          


Ser Cys Phe Ser Asp Tyr Ile Ser Thr Ser Val Cys Gln Trp Lys Met 
        35                  40                  45              


Asp His Pro Thr Asn Cys Ser Ala Glu Leu Arg Leu Ser Tyr Gln Leu 
    50                  55                  60                  


Asp Phe Met Gly Ser Glu Asn His Thr Cys Val Pro Glu Asn Arg Glu 
65                  70                  75                  80  


Asp Ser Val Cys Val Cys Ser Met Pro Ile Asp Asp Ala Val Glu Ala 
                85                  90                  95      


Asp Val Tyr Gln Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Ser 
            100                 105                 110         


Gly Ser Phe Gln Pro Ser Lys His Val Lys Pro Arg Thr Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Ser His Thr Trp Leu Leu Met Trp Thr 
    130                 135                 140                 


Asn Pro Tyr Pro Thr Glu Asn His Leu His Ser Glu Leu Thr Tyr Met 
145                 150                 155                 160 


Val Asn Val Ser Asn Asp Asn Asp Pro Glu Asp Phe Lys Val Tyr Asn 
                165                 170                 175     


Val Thr Tyr Met Gly Pro Thr Leu Arg Leu Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ala Ser Tyr Ser Ala Arg Val Arg Ala Trp Ala Gln Thr Tyr 
        195                 200                 205             


Asn Ser Thr Trp Ser Asp Trp Ser Pro Ser Thr Thr Trp Leu Asn Tyr 
    210                 215                 220                 


Tyr Glu Pro Gly Ser Gly Ser His His His His His His 
225                 230                 235         


<210>  107
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_C-His6

<400>  107

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Gly Ser 
        195                 200                 205             


His His His His His His 
    210                 


<210>  108
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_ C HuFc_His6 with leader

<400>  108

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Ser Gly Ser Val Lys Val Leu His Glu Pro 
            20                  25                  30          


Ser Cys Phe Ser Asp Tyr Ile Ser Thr Ser Val Cys Gln Trp Lys Met 
        35                  40                  45              


Asp His Pro Thr Asn Cys Ser Ala Glu Leu Arg Leu Ser Tyr Gln Leu 
    50                  55                  60                  


Asp Phe Met Gly Ser Glu Asn His Thr Cys Val Pro Glu Asn Arg Glu 
65                  70                  75                  80  


Asp Ser Val Cys Val Cys Ser Met Pro Ile Asp Asp Ala Val Glu Ala 
                85                  90                  95      


Asp Val Tyr Gln Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Ser 
            100                 105                 110         


Gly Ser Phe Gln Pro Ser Lys His Val Lys Pro Arg Thr Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Ser His Thr Trp Leu Leu Met Trp Thr 
    130                 135                 140                 


Asn Pro Tyr Pro Thr Glu Asn His Leu His Ser Glu Leu Thr Tyr Met 
145                 150                 155                 160 


Val Asn Val Ser Asn Asp Asn Asp Pro Glu Asp Phe Lys Val Tyr Asn 
                165                 170                 175     


Val Thr Tyr Met Gly Pro Thr Leu Arg Leu Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ala Ser Tyr Ser Ala Arg Val Arg Ala Trp Ala Gln Thr Tyr 
        195                 200                 205             


Asn Ser Thr Trp Ser Asp Trp Ser Pro Ser Thr Thr Trp Leu Asn Tyr 
    210                 215                 220                 


Tyr Glu Pro Gly Ser Glu Asn Leu Tyr Phe Gln Gly Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys His His His His His His 
465                 470             


<210>  109
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_ C HuFc_His6

<400>  109

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  110
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Feline IL4R-ECD_ C HuFc_His6 with leader

<400>  110

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gly Ser Val Lys Val Leu Arg Ala Pro Thr 
            20                  25                  30          


Cys Phe Ser Asp Tyr Phe Ser Thr Ser Val Cys Gln Trp Asn Met Asp 
        35                  40                  45              


Ala Pro Thr Asn Cys Ser Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asn 
    50                  55                  60                  


Phe Met Gly Ser Glu Asn Arg Thr Cys Val Pro Glu Asn Gly Glu Gly 
65                  70                  75                  80  


Ala Ala Cys Ala Cys Ser Met Leu Met Asp Asp Phe Val Glu Ala Asp 
                85                  90                  95      


Val Tyr Gln Leu His Leu Trp Ala Gly Thr Gln Leu Leu Trp Ser Gly 
            100                 105                 110         


Ser Phe Lys Pro Ser Ser His Val Lys Pro Arg Ala Pro Gly Asn Leu 
        115                 120                 125             


Thr Val His Pro Asn Val Ser His Thr Trp Leu Leu Arg Trp Ser Asn 
    130                 135                 140                 


Pro Tyr Pro Pro Glu Asn His Leu His Ala Glu Leu Thr Tyr Met Val 
145                 150                 155                 160 


Asn Ile Ser Ser Glu Asp Asp Pro Thr Asp Ser Arg Ile Tyr Asn Val 
                165                 170                 175     


Thr Tyr Met Gly Pro Thr Leu Arg Val Ala Ala Ser Thr Leu Thr Ser 
            180                 185                 190         


Gly Ala Ser Tyr Ser Ala Arg Val Arg Ala Trp Ala Gln Ser Tyr Asn 
        195                 200                 205             


Ser Thr Trp Ser Asp Trp Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr 
    210                 215                 220                 


Glu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys His His His His His His 
465                 470     


<210>  111
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Feline IL4R-ECD_ C HuFc_His6

<400>  111

Gly Ser Val Lys Val Leu Arg Ala Pro Thr Cys Phe Ser Asp Tyr Phe 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Asn Met Asp Ala Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asn Phe Met Gly Ser Glu Asn 
        35                  40                  45              


Arg Thr Cys Val Pro Glu Asn Gly Glu Gly Ala Ala Cys Ala Cys Ser 
    50                  55                  60                  


Met Leu Met Asp Asp Phe Val Glu Ala Asp Val Tyr Gln Leu His Leu 
65                  70                  75                  80  


Trp Ala Gly Thr Gln Leu Leu Trp Ser Gly Ser Phe Lys Pro Ser Ser 
                85                  90                  95      


His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Pro Asn Val 
            100                 105                 110         


Ser His Thr Trp Leu Leu Arg Trp Ser Asn Pro Tyr Pro Pro Glu Asn 
        115                 120                 125             


His Leu His Ala Glu Leu Thr Tyr Met Val Asn Ile Ser Ser Glu Asp 
    130                 135                 140                 


Asp Pro Thr Asp Ser Arg Ile Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Val Ala Ala Ser Thr Leu Thr Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Ser Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Gly Ser Glu Asn Leu 
        195                 200                 205             


Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His His 
        435                 440                 445             


His 
    


<210>  112
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Equine IL4R-ECD_ C HuFc_His6 with leader

<400>  112

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Val Lys Val Leu Arg Leu Thr Ala 
            20                  25                  30          


Cys Phe Ser Asp Tyr Ile Ser Ala Ser Thr Cys Glu Trp Lys Met Asp 
        35                  40                  45              


Arg Pro Thr Asn Cys Ser Ala Gln Leu Arg Leu Ser Tyr Gln Leu Asn 
    50                  55                  60                  


Asp Glu Phe Ser Asp Asn Leu Thr Cys Ile Pro Glu Asn Arg Glu Asp 
65                  70                  75                  80  


Glu Val Cys Val Cys Arg Met Leu Met Asp Asn Ile Val Ser Glu Asp 
                85                  90                  95      


Val Tyr Glu Leu Asp Leu Trp Ala Gly Asn Gln Leu Leu Trp Asn Ser 
            100                 105                 110         


Ser Phe Lys Pro Ser Arg His Val Lys Pro Arg Ala Pro Gln Asn Leu 
        115                 120                 125             


Thr Val His Ala Ile Ser His Thr Trp Leu Leu Thr Trp Ser Asn Pro 
    130                 135                 140                 


Tyr Pro Leu Lys Asn His Leu Trp Ser Glu Leu Thr Tyr Leu Val Asn 
145                 150                 155                 160 


Ile Ser Lys Glu Asp Asp Pro Thr Asp Phe Lys Ile Tyr Asn Val Thr 
                165                 170                 175     


Tyr Met Asp Pro Thr Leu Arg Val Thr Ala Ser Thr Leu Lys Ser Arg 
            180                 185                 190         


Ala Thr Tyr Ser Ala Arg Val Lys Ala Arg Ala Gln Asn Tyr Asn Ser 
        195                 200                 205             


Thr Trp Ser Glu Trp Ser Pro Ser Thr Thr Trp His Asn Tyr Tyr Glu 
    210                 215                 220                 


Gln Pro Leu Glu Gln Arg Gly Gly Gly Ser Gly Gly Gly Ser Glu Asn 
225                 230                 235                 240 


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
465                 470                 475                 480 


His His 
        


<210>  113
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Equine IL4R-ECD_ C HuFc_His6

<400>  113

Val Lys Val Leu Arg Leu Thr Ala Cys Phe Ser Asp Tyr Ile Ser Ala 
1               5                   10                  15      


Ser Thr Cys Glu Trp Lys Met Asp Arg Pro Thr Asn Cys Ser Ala Gln 
            20                  25                  30          


Leu Arg Leu Ser Tyr Gln Leu Asn Asp Glu Phe Ser Asp Asn Leu Thr 
        35                  40                  45              


Cys Ile Pro Glu Asn Arg Glu Asp Glu Val Cys Val Cys Arg Met Leu 
    50                  55                  60                  


Met Asp Asn Ile Val Ser Glu Asp Val Tyr Glu Leu Asp Leu Trp Ala 
65                  70                  75                  80  


Gly Asn Gln Leu Leu Trp Asn Ser Ser Phe Lys Pro Ser Arg His Val 
                85                  90                  95      


Lys Pro Arg Ala Pro Gln Asn Leu Thr Val His Ala Ile Ser His Thr 
            100                 105                 110         


Trp Leu Leu Thr Trp Ser Asn Pro Tyr Pro Leu Lys Asn His Leu Trp 
        115                 120                 125             


Ser Glu Leu Thr Tyr Leu Val Asn Ile Ser Lys Glu Asp Asp Pro Thr 
    130                 135                 140                 


Asp Phe Lys Ile Tyr Asn Val Thr Tyr Met Asp Pro Thr Leu Arg Val 
145                 150                 155                 160 


Thr Ala Ser Thr Leu Lys Ser Arg Ala Thr Tyr Ser Ala Arg Val Lys 
                165                 170                 175     


Ala Arg Ala Gln Asn Tyr Asn Ser Thr Trp Ser Glu Trp Ser Pro Ser 
            180                 185                 190         


Thr Thr Trp His Asn Tyr Tyr Glu Gln Pro Leu Glu Gln Arg Gly Gly 
        195                 200                 205             


Gly Ser Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys His His His His His His 
    450                 455             


<210>  114
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Murine IL4R-ECD_ C HuFc_His6 with leader

<400>  114

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Ile Lys Val Leu Gly Glu Pro Thr Cys 
            20                  25                  30          


Phe Ser Asp Tyr Ile Arg Thr Ser Thr Cys Glu Trp Phe Leu Asp Ser 
        35                  40                  45              


Ala Val Asp Cys Ser Ser Gln Leu Cys Leu His Tyr Arg Leu Met Phe 
    50                  55                  60                  


Phe Glu Phe Ser Glu Asn Leu Thr Cys Ile Pro Arg Asn Ser Ala Ser 
65                  70                  75                  80  


Thr Val Cys Val Cys His Met Glu Met Asn Arg Pro Val Gln Ser Asp 
                85                  90                  95      


Arg Tyr Gln Met Glu Leu Trp Ala Glu His Arg Gln Leu Trp Gln Gly 
            100                 105                 110         


Ser Phe Ser Pro Ser Gly Asn Val Lys Pro Leu Ala Pro Asp Asn Leu 
        115                 120                 125             


Thr Leu His Thr Asn Val Ser Asp Glu Trp Leu Leu Thr Trp Asn Asn 
    130                 135                 140                 


Leu Tyr Pro Ser Asn Asn Leu Leu Tyr Lys Asp Leu Ile Ser Met Val 
145                 150                 155                 160 


Asn Ile Ser Arg Glu Asp Asn Pro Ala Glu Phe Ile Val Tyr Asn Val 
                165                 170                 175     


Thr Tyr Lys Glu Pro Arg Leu Ser Phe Pro Ile Asn Ile Leu Met Ser 
            180                 185                 190         


Gly Val Tyr Tyr Thr Ala Arg Val Arg Val Arg Ser Gln Ile Leu Thr 
        195                 200                 205             


Gly Thr Trp Ser Glu Trp Ser Pro Ser Ile Thr Trp Tyr Asn His Phe 
    210                 215                 220                 


Gln Leu Pro Leu Ile Gln Arg Leu Pro Leu Gly Val Thr Ile Ser Cys 
225                 230                 235                 240 


Leu Cys Ile Pro Leu Phe Cys Leu Phe Cys Tyr Phe Ser Ile Thr Lys 
                245                 250                 255     


Ile Lys Lys Ile Trp Gly Ser Glu Asn Leu Tyr Phe Gln Gly Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        275                 280                 285             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly Lys His His His His His His 
            500                 505         


<210>  115
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Murine IL4R-ECD_ C HuFc_His6

<400>  115

Ile Lys Val Leu Gly Glu Pro Thr Cys Phe Ser Asp Tyr Ile Arg Thr 
1               5                   10                  15      


Ser Thr Cys Glu Trp Phe Leu Asp Ser Ala Val Asp Cys Ser Ser Gln 
            20                  25                  30          


Leu Cys Leu His Tyr Arg Leu Met Phe Phe Glu Phe Ser Glu Asn Leu 
        35                  40                  45              


Thr Cys Ile Pro Arg Asn Ser Ala Ser Thr Val Cys Val Cys His Met 
    50                  55                  60                  


Glu Met Asn Arg Pro Val Gln Ser Asp Arg Tyr Gln Met Glu Leu Trp 
65                  70                  75                  80  


Ala Glu His Arg Gln Leu Trp Gln Gly Ser Phe Ser Pro Ser Gly Asn 
                85                  90                  95      


Val Lys Pro Leu Ala Pro Asp Asn Leu Thr Leu His Thr Asn Val Ser 
            100                 105                 110         


Asp Glu Trp Leu Leu Thr Trp Asn Asn Leu Tyr Pro Ser Asn Asn Leu 
        115                 120                 125             


Leu Tyr Lys Asp Leu Ile Ser Met Val Asn Ile Ser Arg Glu Asp Asn 
    130                 135                 140                 


Pro Ala Glu Phe Ile Val Tyr Asn Val Thr Tyr Lys Glu Pro Arg Leu 
145                 150                 155                 160 


Ser Phe Pro Ile Asn Ile Leu Met Ser Gly Val Tyr Tyr Thr Ala Arg 
                165                 170                 175     


Val Arg Val Arg Ser Gln Ile Leu Thr Gly Thr Trp Ser Glu Trp Ser 
            180                 185                 190         


Pro Ser Ile Thr Trp Tyr Asn His Phe Gln Leu Pro Leu Ile Gln Arg 
        195                 200                 205             


Leu Pro Leu Gly Val Thr Ile Ser Cys Leu Cys Ile Pro Leu Phe Cys 
    210                 215                 220                 


Leu Phe Cys Tyr Phe Ser Ile Thr Lys Ile Lys Lys Ile Trp Gly Ser 
225                 230                 235                 240 


Glu Asn Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His 
465                 470                 475                 480 


His His His His 
                


<210>  116
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human IL4R-ECD_ C HuFc_His6  with leader

<400>  116

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Gly Ser Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys His His His His His His 
465                 470                 475             


<210>  117
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human IL4R-ECD_ C HuFc_His6

<400>  117

Gly Asn Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met 
1               5                   10                  15      


Ser Ile Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser 
            20                  25                  30          


Thr Glu Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala 
        35                  40                  45              


His Thr Cys Ile Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His 
    50                  55                  60                  


Leu Leu Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Glu 
                85                  90                  95      


His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn Val 
            100                 105                 110         


Ser Asp Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn 
        115                 120                 125             


Tyr Leu Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn 
    130                 135                 140                 


Asp Pro Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser 
145                 150                 155                 160 


Leu Arg Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Cys Tyr Asn Thr Thr Trp Ser Glu Trp 
            180                 185                 190         


Ser Pro Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu Gln 
        195                 200                 205             


His Gly Ser Glu Asn Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys His His His His His His 
    450                 455 


<210>  118
<211>  132
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<222>  (1)..(132)
<223>  Canine IL4 precursor

<400>  118

Met Gly Leu Thr Ser Gln Leu Ile Pro Thr Leu Val Cys Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Thr Phe Val His Gly His Asn Phe Asn Ile Thr Ile Lys 
            20                  25                  30          


Glu Ile Ile Lys Met Leu Asn Ile Leu Thr Ala Arg Asn Asp Ser Cys 
        35                  40                  45              


Met Glu Leu Thr Val Lys Asp Val Phe Thr Ala Pro Lys Asn Thr Ser 
    50                  55                  60                  


Asp Lys Glu Ile Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Ile Tyr 
65                  70                  75                  80  


Thr His Asn Cys Ser Asn Arg Tyr Leu Arg Gly Leu Tyr Arg Asn Leu 
                85                  90                  95      


Ser Ser Met Ala Asn Lys Thr Cys Ser Met Asn Glu Ile Lys Lys Ser 
            100                 105                 110         


Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Val Ile Met Gln Lys Lys 
        115                 120                 125             


Tyr Tyr Arg His 
    130         


<210>  119
<211>  133
<212>  PRT
<213>  Felis silvestris catus


<220>
<221>  misc_feature
<222>  (1)..(133)
<223>  Feline IL4 precursor

<400>  119

Met Gly Leu Thr Tyr Gln Leu Ile Pro Ala Leu Val Cys Leu Leu Ala 
1               5                   10                  15      


Phe Thr Ser Thr Phe Val His Gly Gln Asn Phe Asn Asn Thr Leu Lys 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ile Leu Thr Ala Arg Asn Asp Ser Cys 
        35                  40                  45              


Met Glu Leu Thr Val Met Asp Val Leu Ala Ala Pro Lys Asn Thr Ser 
    50                  55                  60                  


Asp Lys Glu Ile Phe Cys Arg Ala Thr Thr Val Leu Arg Gln Ile Tyr 
65                  70                  75                  80  


Thr His His Asn Cys Ser Thr Lys Phe Leu Lys Gly Leu Asp Arg Asn 
                85                  90                  95      


Leu Ser Ser Met Ala Asn Arg Thr Cys Ser Val Asn Glu Val Lys Lys 
            100                 105                 110         


Cys Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Ala Ile Met Gln Lys 
        115                 120                 125             


Lys Tyr Ser Lys His 
    130             


<210>  120
<211>  137
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<222>  (1)..(137)
<223>  Equine IL4 precursor

<400>  120

Met Gly Leu Thr Tyr Gln Leu Ile Pro Ala Leu Val Cys Leu Leu Ala 
1               5                   10                  15      


Cys Thr Ser Asn Phe Ile Gln Gly Cys Lys Tyr Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Asn Leu Thr Asp Gly Lys Gly Lys Asn 
        35                  40                  45              


Ser Cys Met Glu Leu Thr Val Ala Asp Ala Phe Ala Gly Pro Lys Asn 
    50                  55                  60                  


Thr Asp Gly Lys Glu Ile Cys Arg Ala Ala Lys Val Leu Gln Gln Leu 
65                  70                  75                  80  


Tyr Lys Arg His Asp Arg Ser Leu Ile Lys Glu Cys Leu Ser Gly Leu 
                85                  90                  95      


Asp Arg Asn Leu Lys Gly Met Ala Asn Gly Thr Cys Cys Thr Val Asn 
            100                 105                 110         


Glu Ala Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Thr 
        115                 120                 125             


Ile Met Lys Glu Lys Tyr Ser Lys Cys 
    130                 135         


<210>  121
<211>  132
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<222>  (1)..(132)
<223>  Canine IL4 precursor

<400>  121

Met Gly Leu Thr Ser Gln Leu Ile Pro Thr Leu Val Cys Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Thr Phe Val His Gly His Asn Phe Asn Ile Thr Ile Lys 
            20                  25                  30          


Glu Ile Ile Lys Met Leu Asn Ile Leu Thr Ala Arg Asn Asp Ser Cys 
        35                  40                  45              


Met Glu Leu Thr Val Lys Asp Val Phe Thr Ala Pro Lys Asn Thr Ser 
    50                  55                  60                  


Asp Lys Glu Ile Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Ile Tyr 
65                  70                  75                  80  


Thr His Asn Cys Ser Asn Arg Tyr Leu Arg Gly Leu Tyr Arg Asn Leu 
                85                  90                  95      


Ser Ser Met Ala Asn Lys Thr Cys Ser Met Asn Glu Ile Lys Lys Ser 
            100                 105                 110         


Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Val Ile Met Gln Lys Lys 
        115                 120                 125             


Tyr Tyr Arg His 
    130         


<210>  122
<211>  133
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(133)
<223>  Feline IL4 precursor

<400>  122

Met Asp Leu Thr Ser Gln Leu Ile Pro Ala Leu Val Cys Leu Leu Ala 
1               5                   10                  15      


Phe Thr Ser Thr Phe Val His Gly Gln Asn Phe Asn Asn Thr Leu Lys 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ile Leu Thr Ala Arg Asn Asp Ser Cys 
        35                  40                  45              


Met Glu Leu Thr Val Met Asp Val Leu Ala Ala Pro Lys Asn Thr Ser 
    50                  55                  60                  


Asp Lys Glu Ile Phe Cys Arg Ala Thr Thr Val Leu Arg Gln Ile Tyr 
65                  70                  75                  80  


Thr His His Asn Cys Ser Thr Lys Phe Leu Lys Gly Leu Asp Arg Asn 
                85                  90                  95      


Leu Ser Ser Met Ala Asn Arg Thr Cys Ser Val Asn Glu Val Lys Lys 
            100                 105                 110         


Cys Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Ala Ile Met Gln Lys 
        115                 120                 125             


Lys Tyr Ser Lys His 
    130             


<210>  123
<211>  139
<212>  PRT
<213>  Equus przewalskii


<220>
<221>  misc_feature
<222>  (1)..(139)
<223>  Predicted Equine IL4 precursor

<400>  123

Met Gly Leu Ile Ser Gln Leu Ile Pro Ala Leu Val Cys Leu Leu Ala 
1               5                   10                  15      


Cys Thr Ser Asn Phe Ile Gln Gly Cys Lys Tyr Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Asn Leu Thr Asp Gly Lys Gly Lys Asn 
        35                  40                  45              


Ser Cys Met Glu Leu Thr Val Ala Asp Ala Phe Ala Gly Pro Lys Asn 
    50                  55                  60                  


Thr Asp Gly Lys Glu Ile Cys Arg Ala Ala Lys Val Leu Gln Gln Leu 
65                  70                  75                  80  


Tyr Lys Arg His Asp Arg Ser Leu Ile Lys Glu Cys Leu Ser Gly Leu 
                85                  90                  95      


Asp Arg Asn Leu Lys Gly Met Ala Asn Gly Thr Cys Cys Thr Val Asn 
            100                 105                 110         


Glu Ala Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Thr 
        115                 120                 125             


Ile Met Lys Glu Lys Tyr Ser Lys Cys Gln Ser 
    130                 135                 


<210>  124
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4_N-His6 with leader

<400>  124

Met Gly Leu Thr Ser Gln Leu Ile Pro Thr Leu Val Cys Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Thr Phe Val His Gly Ser Ser His His His His His His 
            20                  25                  30          


Ser Ser Gly Leu Val Pro Arg Gly Ser His Met His Asn Phe Asn Ile 
        35                  40                  45              


Thr Ile Lys Glu Ile Ile Lys Met Leu Asn Ile Leu Thr Ala Arg Asn 
    50                  55                  60                  


Asp Ser Cys Met Glu Leu Thr Val Lys Asp Val Phe Thr Ala Pro Lys 
65                  70                  75                  80  


Asn Thr Ser Asp Lys Glu Ile Phe Cys Arg Ala Ala Thr Val Leu Arg 
                85                  90                  95      


Gln Ile Tyr Thr His Asn Cys Ser Asn Arg Tyr Leu Arg Gly Leu Tyr 
            100                 105                 110         


Arg Asn Leu Ser Ser Met Ala Asn Lys Thr Cys Ser Met Asn Glu Ile 
        115                 120                 125             


Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Val Ile Met 
    130                 135                 140                 


Gln Lys Lys Tyr Tyr Arg His 
145                 150     


<210>  125
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4_N-His6

<400>  125

Ser His His His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser 
1               5                   10                  15      


His Met His Asn Phe Asn Ile Thr Ile Lys Glu Ile Ile Lys Met Leu 
            20                  25                  30          


Asn Ile Leu Thr Ala Arg Asn Asp Ser Cys Met Glu Leu Thr Val Lys 
        35                  40                  45              


Asp Val Phe Thr Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile Phe Cys 
    50                  55                  60                  


Arg Ala Ala Thr Val Leu Arg Gln Ile Tyr Thr His Asn Cys Ser Asn 
65                  70                  75                  80  


Arg Tyr Leu Arg Gly Leu Tyr Arg Asn Leu Ser Ser Met Ala Asn Lys 
                85                  90                  95      


Thr Cys Ser Met Asn Glu Ile Lys Lys Ser Thr Leu Lys Asp Phe Leu 
            100                 105                 110         


Glu Arg Leu Lys Val Ile Met Gln Lys Lys Tyr Tyr Arg His 
        115                 120                 125     


<210>  126
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4_C-His6 with leader

<400>  126

Met Gly Leu Thr Ser Gln Leu Ile Pro Thr Leu Val Cys Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Thr Phe Val His Gly His Asn Phe Asn Ile Thr Ile Lys 
            20                  25                  30          


Glu Ile Ile Lys Met Leu Asn Ile Leu Thr Ala Arg Asn Asp Ser Cys 
        35                  40                  45              


Met Glu Leu Thr Val Lys Asp Val Phe Thr Ala Pro Lys Asn Thr Ser 
    50                  55                  60                  


Asp Lys Glu Ile Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Ile Tyr 
65                  70                  75                  80  


Thr His Asn Cys Ser Asn Arg Tyr Leu Arg Gly Leu Tyr Arg Asn Leu 
                85                  90                  95      


Ser Ser Met Ala Asn Lys Thr Cys Ser Met Asn Glu Ile Lys Lys Ser 
            100                 105                 110         


Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Val Ile Met Gln Lys Lys 
        115                 120                 125             


Tyr Tyr Arg His His His His His His 
    130                 135         


<210>  127
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4_C-His6

<400>  127

His Asn Phe Asn Ile Thr Ile Lys Glu Ile Ile Lys Met Leu Asn Ile 
1               5                   10                  15      


Leu Thr Ala Arg Asn Asp Ser Cys Met Glu Leu Thr Val Lys Asp Val 
            20                  25                  30          


Phe Thr Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Ile Tyr Thr His Asn Cys Ser Asn Arg Tyr 
    50                  55                  60                  


Leu Arg Gly Leu Tyr Arg Asn Leu Ser Ser Met Ala Asn Lys Thr Cys 
65                  70                  75                  80  


Ser Met Asn Glu Ile Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu Arg 
                85                  90                  95      


Leu Lys Val Ile Met Gln Lys Lys Tyr Tyr Arg Gly Ser Gly Ser His 
            100                 105                 110         


His His His His His 
        115         


<210>  128
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Feline IL4_C-His6 with leader

<400>  128

Met Asp Leu Thr Ser Gln Leu Ile Pro Ala Leu Val Cys Leu Leu Ala 
1               5                   10                  15      


Phe Thr Ser Thr Phe Val His Gly Gln Asn Phe Asn Asn Thr Leu Lys 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ile Leu Thr Ala Arg Asn Asp Ser Cys 
        35                  40                  45              


Met Glu Leu Thr Val Met Asp Val Leu Ala Ala Pro Lys Asn Thr Ser 
    50                  55                  60                  


Asp Lys Glu Ile Phe Cys Arg Ala Thr Thr Val Leu Arg Gln Ile Tyr 
65                  70                  75                  80  


Thr His His Asn Cys Ser Thr Lys Phe Leu Lys Gly Leu Asp Arg Asn 
                85                  90                  95      


Leu Ser Ser Met Ala Asn Arg Thr Cys Ser Val Asn Glu Val Lys Lys 
            100                 105                 110         


Cys Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Ala Ile Met Gln Lys 
        115                 120                 125             


Lys Tyr Ser Lys His Gly Ser Gly Ser His His His His His His 
    130                 135                 140             


<210>  129
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Feline IL4_C-His6

<400>  129

Gln Asn Phe Asn Asn Thr Leu Lys Glu Ile Ile Lys Thr Leu Asn Ile 
1               5                   10                  15      


Leu Thr Ala Arg Asn Asp Ser Cys Met Glu Leu Thr Val Met Asp Val 
            20                  25                  30          


Leu Ala Ala Pro Lys Asn Thr Ser Asp Lys Glu Ile Phe Cys Arg Ala 
        35                  40                  45              


Thr Thr Val Leu Arg Gln Ile Tyr Thr His His Asn Cys Ser Thr Lys 
    50                  55                  60                  


Phe Leu Lys Gly Leu Asp Arg Asn Leu Ser Ser Met Ala Asn Arg Thr 
65                  70                  75                  80  


Cys Ser Val Asn Glu Val Lys Lys Cys Thr Leu Lys Asp Phe Leu Glu 
                85                  90                  95      


Arg Leu Lys Ala Ile Met Gln Lys Lys Tyr Ser Lys His Gly Ser Gly 
            100                 105                 110         


Ser His His His His His His 
        115                 


<210>  130
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Equine IL4_C-His6 with leader

<400>  130

Met Gly Leu Ile Ser Gln Leu Ile Pro Ala Leu Val Cys Leu Leu Ala 
1               5                   10                  15      


Cys Thr Ser Asn Phe Ile Gln Gly Cys Lys Tyr Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Asn Leu Thr Asp Gly Lys Gly Lys Asn 
        35                  40                  45              


Ser Cys Met Glu Leu Thr Val Ala Asp Ala Phe Ala Gly Pro Lys Asn 
    50                  55                  60                  


Thr Asp Gly Lys Glu Ile Cys Arg Ala Ala Lys Val Leu Gln Gln Leu 
65                  70                  75                  80  


Tyr Lys Arg His Asp Arg Ser Leu Ile Lys Glu Cys Leu Ser Gly Leu 
                85                  90                  95      


Asp Arg Asn Leu Lys Gly Met Ala Asn Gly Thr Cys Cys Thr Val Asn 
            100                 105                 110         


Glu Ala Lys Lys Ser Thr Leu Lys Asp Phe Leu Glu Arg Leu Lys Thr 
        115                 120                 125             


Ile Met Lys Glu Lys Tyr Ser Lys Cys Gln Gly Ser Gly Ser His His 
    130                 135                 140                 


His His His His 
145             


<210>  131
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Equine IL4_C-His6

<400>  131

Cys Lys Tyr Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Asn 
1               5                   10                  15      


Leu Thr Asp Gly Lys Gly Lys Asn Ser Cys Met Glu Leu Thr Val Ala 
            20                  25                  30          


Asp Ala Phe Ala Gly Pro Lys Asn Thr Asp Gly Lys Glu Ile Cys Arg 
        35                  40                  45              


Ala Ala Lys Val Leu Gln Gln Leu Tyr Lys Arg His Asp Arg Ser Leu 
    50                  55                  60                  


Ile Lys Glu Cys Leu Ser Gly Leu Asp Arg Asn Leu Lys Gly Met Ala 
65                  70                  75                  80  


Asn Gly Thr Cys Cys Thr Val Asn Glu Ala Lys Lys Ser Thr Leu Lys 
                85                  90                  95      


Asp Phe Leu Glu Arg Leu Lys Thr Ile Met Lys Glu Lys Tyr Ser Lys 
            100                 105                 110         


Cys Gln Gly Ser Gly Ser His His His His His His 
        115                 120                 


<210>  132
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: exemplary leader sequence

<400>  132

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  133
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C-HuFc_His6_ Fusion1 (Fusion 1)

<400>  133

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His 
    50                  55                  60                  


Leu Leu Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Glu 
                85                  90                  95      


His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn Val 
            100                 105                 110         


Ser Asp Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn 
        115                 120                 125             


Tyr Leu Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn 
    130                 135                 140                 


Asp Pro Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser 
145                 150                 155                 160 


Leu Arg Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Cys Tyr Asn Thr Thr Trp Ser Glu Trp 
            180                 185                 190         


Ser Pro Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu Gln 
        195                 200                 205             


His Gly Ser Glu Asn Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys His His His His His His 
    450                 455 


<210>  134
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C-HuFc_His6_ Fusion2 (Fusion 2)

<400>  134

Gly Asn Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met 
1               5                   10                  15      


Ser Ile Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser 
            20                  25                  30          


Thr Glu Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala 
        35                  40                  45              


His Thr Cys Ile Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Thr Asn Val 
            100                 105                 110         


Ser Asp Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn 
        115                 120                 125             


Tyr Leu Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn 
    130                 135                 140                 


Asp Pro Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser 
145                 150                 155                 160 


Leu Arg Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Cys Tyr Asn Thr Thr Trp Ser Glu Trp 
            180                 185                 190         


Ser Pro Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu Gln 
        195                 200                 205             


His Gly Ser Glu Asn Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys His His His His His His 
    450                 455 


<210>  135
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C-HuFc_His6_ Fusion3 (Fusion 3)

<400>  135

Gly Asn Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met 
1               5                   10                  15      


Ser Ile Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser 
            20                  25                  30          


Thr Glu Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala 
        35                  40                  45              


His Thr Cys Ile Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His 
    50                  55                  60                  


Leu Leu Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Glu 
                85                  90                  95      


His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  136
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C-HuFc_His6_ Fusion4 (Fusion 4)

<400>  136

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Thr Asn Val 
            100                 105                 110         


Ser Asp Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn 
        115                 120                 125             


Tyr Leu Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn 
    130                 135                 140                 


Asp Pro Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser 
145                 150                 155                 160 


Leu Arg Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Cys Tyr Asn Thr Thr Trp Ser Glu Trp 
            180                 185                 190         


Ser Pro Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu Gln 
        195                 200                 205             


His Gly Ser Glu Asn Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys His His His His His His 
    450                 455 


<210>  137
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C-HuFc_His6_ Fusion5 (Fusion 5)

<400>  137

Gly Asn Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met 
1               5                   10                  15      


Ser Ile Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser 
            20                  25                  30          


Thr Glu Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala 
        35                  40                  45              


His Thr Cys Ile Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  138
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C-HuFc_His6_ Fusion6 (Fusion 6)

<400>  138

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His 
    50                  55                  60                  


Leu Leu Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Glu 
                85                  90                  95      


His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  139
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C-HuFc_His6_ Fusion7 (Fusion 7)

<400>  139

Gly Asn Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met 
1               5                   10                  15      


Ser Ile Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  140
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C-HuFc_His6_ Fusion8 (Fusion 8)

<400>  140

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Thr Glu Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala 
        35                  40                  45              


His Thr Cys Ile Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  141
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C-HuFc_His6_ Fusion9 (Fusion 9)

<400>  141

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Thr Glu Leu Arg Leu Leu Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  142
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C HuFc_His6_ Fusion10  (Fusion 
       10)

<400>  142

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala 
        35                  40                  45              


His Thr Cys Ile Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  143
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C HuFc_His6_ Fusion11 (Fusion 
       11)

<400>  143

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His 
    50                  55                  60                  


Leu Leu Met Asp Asp Val Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  144
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_C HuFc_His6_ Fusion12 (Fusion 
       12)

<400>  144

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  145
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_C HuFc_His6_ Fusion13 (Fusion 
       13)

<400>  145

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Lys Pro Ser Glu 
                85                  90                  95      


His Val Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  146
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine/Human IL4R-ECD_ C HuFc_His6_ Fusion14 (Fusion 
       14)

<400>  146

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  147
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_ C HuFc_His6.A33T (Mutant 1)

<400>  147

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Thr Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  148
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_ C HuFc_His6.M44A (Mutant 2)

<400>  148

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Ala Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  149
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_ C HuFc_His6.G45A (Mutant 3)

<400>  149

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Ala Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  150
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_ C HuFc_His6.N48A (Mutant 4)

<400>  150

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Ala 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  151
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_ C HuFc_His6.S38A (Mutant 5)

<400>  151

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ala Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  152
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_ C HuFc_His6.D42A  (Mutant 6)

<400>  152

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Ala Phe Met Gly Ser Glu Asn 
        35                  40                  45              


His Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  153
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL4R-ECD_ C HuFc_His6.H49A  (Mutant 7)

<400>  153

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala Glu Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn 
        35                  40                  45              


Ala Thr Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser 
    50                  55                  60                  


Met Pro Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu 
65                  70                  75                  80  


Trp Ala Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys 
                85                  90                  95      


His Val Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile 
            100                 105                 110         


Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn 
        115                 120                 125             


His Leu His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn 
    130                 135                 140                 


Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr 
145                 150                 155                 160 


Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala 
                165                 170                 175     


Arg Val Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp 
            180                 185                 190         


Ser Pro Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Gly Ser Glu Asn 
        195                 200                 205             


Leu Tyr Phe Gln Gly Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
        435                 440                 445             


His His 
    450 


<210>  154
<211>  131
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<222>  (1)..(131)
<223>  Canine IL13 precursor

<400>  154

Met Ala Leu Trp Leu Thr Val Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Leu Ala Ser Pro Ser Pro Val Thr Pro Ser Pro Thr Leu Lys Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Ala Ser Leu Cys Asn 
        35                  40                  45              


Gly Ser Met Val Trp Ser Val Asn Leu Thr Ala Gly Met Tyr Cys Ala 
    50                  55                  60                  


Ala Leu Glu Ser Leu Ile Asn Val Ser Asp Cys Ser Ala Ile Gln Arg 
65                  70                  75                  80  


Thr Gln Arg Met Leu Lys Ala Leu Cys Ser Gln Lys Pro Ala Ala Gly 
                85                  90                  95      


Gln Ile Ser Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu Val Ile Gln 
            100                 105                 110         


Leu Val Lys Asn Leu Leu Thr Tyr Val Arg Gly Val Tyr Arg His Gly 
        115                 120                 125             


Asn Phe Arg 
    130     


<210>  155
<211>  184
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(184)
<223>  Feline IL13 precursor

<400>  155

Met Trp Phe Leu Asp Ser Thr Arg Gln Ser Gly Asp Gln Gly Gly Arg 
1               5                   10                  15      


Arg His Thr Trp Pro Ile Lys Ala Thr Ala Arg Gly Gln Gly His Lys 
            20                  25                  30          


Pro Leu Ser Leu Gly Gln Pro Thr Cys Pro Leu Leu Ala Pro Pro Val 
        35                  40                  45              


Leu Ala Leu Gly Ser Met Ala Leu Trp Leu Thr Val Val Ile Ala Leu 
    50                  55                  60                  


Thr Cys Leu Gly Gly Leu Ala Ser Pro Gly Pro His Ser Arg Arg Glu 
65                  70                  75                  80  


Leu Lys Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Val 
                85                  90                  95      


Ser Leu Cys Asn Gly Ser Met Val Trp Ser Val Asn Leu Thr Thr Gly 
            100                 105                 110         


Met Gln Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Asp Cys 
        115                 120                 125             


Thr Ala Ile Gln Arg Thr Gln Arg Met Leu Lys Ala Leu Cys Thr Gln 
    130                 135                 140                 


Lys Pro Ser Ala Gly Gln Thr Ala Ser Glu Arg Ser Arg Asp Thr Lys 
145                 150                 155                 160 


Ile Glu Val Ile Gln Leu Val Lys Asn Leu Leu Asn His Leu Arg Arg 
                165                 170                 175     


Asn Phe Arg His Gly Asn Phe Lys 
            180                 


<210>  156
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL13_C-His6 with leader

<400>  156

Met Ala Leu Trp Leu Thr Val Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Leu Ala Ser Pro Ser Pro Val Thr Pro Ser Pro Thr Leu Lys Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Ala Ser Leu Cys Asn 
        35                  40                  45              


Gly Ser Met Val Trp Ser Val Asn Leu Thr Ala Gly Met Tyr Cys Ala 
    50                  55                  60                  


Ala Leu Glu Ser Leu Ile Asn Val Ser Asp Cys Ser Ala Ile Gln Arg 
65                  70                  75                  80  


Thr Gln Arg Met Leu Lys Ala Leu Cys Ser Gln Lys Pro Ala Ala Gly 
                85                  90                  95      


Gln Ile Ser Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu Val Ile Gln 
            100                 105                 110         


Leu Val Lys Asn Leu Leu Thr Tyr Val Arg Gly Val Tyr Arg His Gly 
        115                 120                 125             


Asn Phe Arg Gly Ser His His His His His His 
    130                 135                 


<210>  157
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL13_C-His6

<400>  157

Ser Pro Ser Pro Val Thr Pro Ser Pro Thr Leu Lys Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Val Asn Ile Thr Gln Asn Gln Ala Ser Leu Cys Asn Gly Ser 
            20                  25                  30          


Met Val Trp Ser Val Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu 
        35                  40                  45              


Glu Ser Leu Ile Asn Val Ser Asp Cys Ser Ala Ile Gln Arg Thr Gln 
    50                  55                  60                  


Arg Met Leu Lys Ala Leu Cys Ser Gln Lys Pro Ala Ala Gly Gln Ile 
65                  70                  75                  80  


Ser Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu Val Ile Gln Leu Val 
                85                  90                  95      


Lys Asn Leu Leu Thr Tyr Val Arg Gly Val Tyr Arg His Gly Asn Phe 
            100                 105                 110         


Arg Gly Ser His His His His His His 
        115                 120     


<210>  158
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Feline IL13_C-His6 with leader

<400>  158

Met Ala Leu Trp Leu Thr Val Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Leu Ala Ser Pro Gly Pro His Ser Arg Arg Glu Leu Lys Glu Leu Ile 
            20                  25                  30          


Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Leu Leu Gln Val Ser Leu 
        35                  40                  45              


Cys Asn Gly Ser Met Val Trp Ser Val Asn Leu Thr Thr Gly Met Gln 
    50                  55                  60                  


Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Asp Cys Thr Ala 
65                  70                  75                  80  


Ile Gln Arg Thr Gln Arg Met Leu Lys Ala Leu Cys Thr Gln Lys Pro 
                85                  90                  95      


Ser Ala Gly Gln Thr Ala Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu 
            100                 105                 110         


Val Ile Gln Leu Val Lys Asn Leu Leu Asn His Leu Arg Arg Asn Phe 
        115                 120                 125             


Arg His Gly Asn Phe Lys Gly Ser Gly Ser His His His His His His 
    130                 135                 140                 


<210>  159
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Feline IL13_C-His6

<400>  159

Ser Pro Gly Pro His Ser Arg Arg Glu Leu Lys Glu Leu Ile Glu Glu 
1               5                   10                  15      


Leu Val Asn Ile Thr Gln Asn Gln Leu Leu Gln Val Ser Leu Cys Asn 
            20                  25                  30          


Gly Ser Met Val Trp Ser Val Asn Leu Thr Thr Gly Met Gln Tyr Cys 
        35                  40                  45              


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Asp Cys Thr Ala Ile Gln 
    50                  55                  60                  


Arg Thr Gln Arg Met Leu Lys Ala Leu Cys Thr Gln Lys Pro Ser Ala 
65                  70                  75                  80  


Gly Gln Thr Ala Ser Glu Arg Ser Arg Asp Thr Lys Ile Glu Val Ile 
                85                  90                  95      


Gln Leu Val Lys Asn Leu Leu Asn His Leu Arg Arg Asn Phe Arg His 
            100                 105                 110         


Gly Asn Phe Lys Gly Ser Gly Ser His His His His His His 
        115                 120                 125     


<210>  160
<211>  427
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<222>  (1)..(427)
<223>  Canine IL13R

<400>  160

Met Glu Arg Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Ala Gly Gly Arg Gly Gly Gly Val Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asp Pro Pro Glu Gly Ala Ser Pro Asn Cys Thr Leu 
    50                  55                  60                  


Arg Tyr Phe Ser His Phe Asp Asn Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr His Arg Ser Lys Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Asp Asn Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Thr Pro Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Val Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Thr Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Ser Ser Leu Gly Lys Ile Leu Gln Cys Glu Asp Ile 
                165                 170                 175     


Tyr Arg Glu Gly Gln His Ile Gly Cys Ser Phe Ala Leu Thr Asn Leu 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Val Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Arg Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


His Val Lys Pro Asp Pro Pro His Ile Lys Arg Leu Phe Phe Gln Asn 
225                 230                 235                 240 


Gly Asn Leu Tyr Val Gln Trp Lys Asn Pro Gln Asn Phe Tyr Ser Arg 
                245                 250                 255     


Cys Leu Ser Tyr Gln Val Glu Val Asn Asn Ser Gln Thr Glu Thr Asn 
            260                 265                 270         


Asp Ile Phe Tyr Val Glu Glu Ala Lys Cys Gln Asn Ser Glu Phe Glu 
        275                 280                 285             


Gly Asn Leu Glu Gly Thr Ile Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Arg Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Ala Met Ser Ile 
                325                 330                 335     


Gly Glu Asn Thr Asp Pro Thr Phe Tyr Ile Thr Met Leu Leu Ala Thr 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Arg 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


<210>  161
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine IL13R ECD

<400>  161

Thr Glu Thr Gln Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn 
1               5                   10                  15      


Leu Cys Thr Val Ile Trp Thr Trp Asp Pro Pro Glu Gly Ala Ser Pro 
            20                  25                  30          


Asn Cys Thr Leu Arg Tyr Phe Ser His Phe Asp Asn Lys Gln Asp Lys 
        35                  40                  45              


Lys Ile Ala Pro Glu Thr His Arg Ser Lys Glu Val Pro Leu Asn Glu 
    50                  55                  60                  


Arg Ile Cys Leu Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Asp 
65                  70                  75                  80  


Asn Pro Ser Ile Leu Val Glu Lys Cys Thr Pro Pro Pro Glu Gly Asp 
                85                  90                  95      


Pro Glu Ser Ala Val Thr Glu Leu Gln Cys Val Trp His Asn Leu Ser 
            100                 105                 110         


Tyr Met Lys Cys Thr Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr 
        115                 120                 125             


Asn Tyr Thr Leu Tyr Tyr Trp His Ser Ser Leu Gly Lys Ile Leu Gln 
    130                 135                 140                 


Cys Glu Asp Ile Tyr Arg Glu Gly Gln His Ile Gly Cys Ser Phe Ala 
145                 150                 155                 160 


Leu Thr Asn Leu Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile 
                165                 170                 175     


Val Val Lys Asp Asn Ala Gly Lys Ile Arg Pro Ser Phe Asn Ile Val 
            180                 185                 190         


Pro Leu Thr Ser His Val Lys Pro Asp Pro Pro His Ile Lys Arg Leu 
        195                 200                 205             


Phe Phe Gln Asn Gly Asn Leu Tyr Val Gln Trp Lys Asn Pro Gln Asn 
    210                 215                 220                 


Phe Tyr Ser Arg Cys Leu Ser Tyr Gln Val Glu Val Asn Asn Ser Gln 
225                 230                 235                 240 


Thr Glu Thr Asn Asp Ile Phe Tyr Val Glu Glu Ala Lys Cys Gln Asn 
                245                 250                 255     


Ser Glu Phe Glu Gly Asn Leu Glu Gly Thr Ile Cys Phe Met Val Pro 
            260                 265                 270         


Gly Val Leu Pro Asp Thr Leu Asn Thr Val Arg Ile Arg Val Arg Thr 
        275                 280                 285             


Asn Lys Leu Cys Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln 
    290                 295                 300                 


Ala Met Ser Ile Gly Glu Asn Thr Asp Pro Thr 
305                 310                 315 


<210>  162
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-A Fc   Protein A  C1q 
       CD16

<400>  162

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  163
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-B Fc   Protein A + C1q 
       + CD16 +

<400>  163

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  164
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-B Fc with hinge Protein
       A + C1q + CD16 +

<400>  164

Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser 
    50                  55                  60                  


Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn 
            100                 105                 110         


Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg 
        115                 120                 125             


Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe 
145                 150                 155                 160 


Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
                165                 170                 175     


Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly 
            180                 185                 190         


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
225                 230                 235         


<210>  165
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-C Fc   Protein A   C1q 
       + CD16 +

<400>  165

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  166
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-C Fc with hinge Protein
       A   C1q + CD16 +

<400>  166

Ala Lys Glu Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro 
1               5                   10                  15      


Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
                85                  90                  95      


Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln 
        115                 120                 125             


Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met 
    130                 135                 140                 


Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro 
145                 150                 155                 160 


Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
                165                 170                 175     


Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
        195                 200                 205             


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
225                 230                 235 


<210>  167
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-D Fc   Protein A  C1q 
       CD16

<400>  167

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu Gln Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  168
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-A Fc   C1q  Protein A + 
       I(21)T R(23)L T(25)A E(80)G T(205)A Q(207)H

<400>  168

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  169
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-A Fc   C1q  Protein A + 
       I(21)T Q(207)H

<400>  169

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  170
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q 
       K(93)R

<400>  170

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  171
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   M(5)P

<400>  171

Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  172
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   P(39)R

<400>  172

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  173
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   D(38)G

<400>  173

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  174
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   K(97)I

<400>  174

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  175
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   A(98)G

<400>  175

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  176
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16  D(38)G  K(97)I A(98)G

<400>  176

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  177
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q 
       CD16  D(38)G  K(93)R K(97)I A(98)G

<400>  177

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  178
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   M(5)P P(39)R

<400>  178

Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  179
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q 
       CD16  M(5)P P(39)R K(93)R

<400>  179

Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  180
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc   C1q + Protein A + 
       I(21)T V(23)L T(24)I

<400>  180

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  181
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc   C1q + Protein A + 
       I(21)T

<400>  181

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  182
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q 
       K(93)R

<400>  182

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  183
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc   C1q    K(93)R 
       Protein A + I(21)T V(23)L T(24)I

<400>  183

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  184
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A + C1q + 
       CD16   L(5)P

<400>  184

Pro Gly Cys Gly Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  185
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A + C1q + 
       CD16   P(39)R

<400>  185

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  186
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A + C1q + 
       CD16   D(38)G

<400>  186

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  187
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A + C1q + 
       CD16   K(97)I

<400>  187

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  188
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A + C1q + 
       CD16   A(98)G

<400>  188

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Gly Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  189
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A + C1q + 
       CD16  D(38)G  K(97)I A(98)G

<400>  189

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  190
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A + C1q 
       CD16  D(38)G  K(93)R K(97)I A(98)G

<400>  190

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  191
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A + C1q + 
       CD16   L(5)P P(39)R

<400>  191

Pro Gly Cys Gly Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  192
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A + C1q 
       CD16  M(5)P P(39)R K(93)R

<400>  192

Pro Gly Cys Gly Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  193
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-D Fc   C1q  Protein A + 
       I(21)T R(23)L T(25)A E(80)G Q(207)H

<400>  193

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  194
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-D Fc   C1q  Protein A + 
       I(21)T Q(207)H

<400>  194

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  195
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-A Fc   Bispecific knob 
       T(138)W

<400>  195

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Trp Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  196
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Bispecific knob 
       T(137)W

<400>  196

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Trp Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  197
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc   Bispecific knob 
       T(137)W

<400>  197

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Trp Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  198
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-D Fc  Bispecific knob 
       T(138)W

<400>  198

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Trp Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu Gln Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  199
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-A Fc   Bispecific hole 
       T(138)S L(140)A

<400>  199

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Ser Cys Ala Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  200
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Bispecific hole 
       T(137)S L(139)A

<400>  200

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Ser Cys Ala Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  201
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Bispecific hole 
       T(137)S L(139)A

<400>  201

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Ser Cys Ala Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  202
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-D Fc  Bispecific hole 
       T(138)S L(140)A

<400>  202

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Ser Cys Ala Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu Gln Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  203
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1a Fc  Protein A + C1q +

<400>  203

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  204
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1a Fc  Protein A + C1q +

<400>  204

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  205
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1b Fc  Protein A + C1q +

<400>  205

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  206
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1b Fc  Protein A + C1q +

<400>  206

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  207
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG2 Fc  Protein A + C1q

<400>  207

Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  208
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc with modified hinge 
       K(16)P

<400>  208

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Pro 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  209
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc  Protein A + C1q 
       P(198)A

<400>  209

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  210
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc  Protein A + C1q 
       P(198)A

<400>  210

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  211
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc with modified hinge 
       K(16)P

<400>  211

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Pro 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  212
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc  Protein A + C1q 
       P(198)A

<400>  212

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  213
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc  Protein A + C1q 
       P(198)A

<400>  213

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  214
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG2 Fc with modified hinge 
       Hinge Cys G(14)C

<400>  214

Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Cys Pro Lys 
1               5                   10                  15      


Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  215
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG2 Fc with modified hinge 
       K(16)P

<400>  215

Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly Pro Pro 
1               5                   10                  15      


Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  216
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG2 Fc with feline IgG1 
       hinge

<400>  216

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  217
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc  Bispecific knob 
       T(154)W

<400>  217

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Trp Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  218
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc  Bispecific knob 
       T(154)W

<400>  218

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Trp Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  219
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc  Bispecific knob 
       T(154)W

<400>  219

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Trp Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  220
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc  Bispecific knob 
       T(154)W

<400>  220

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Trp Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  221
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG2 Fc  Bispecific knob 
       T(154)W

<400>  221

Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Trp Cys Leu Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  222
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc  Bispecific hole 
       T(154)S, L(156)A

<400>  222

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Ser Cys Ala Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  223
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc  Bispecific hole 
       T(154)S, L(156)A

<400>  223

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Ser Cys Ala Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  224
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc  Bispecific hole 
       T(154)S, L(156)A

<400>  224

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Ser Cys Ala Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  225
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc  Bispecific hole 
       T(154)S, L(156)A

<400>  225

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Ser Cys Ala Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  226
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG2 Fc  Bispecific hole 
       T(154)S, L(156)A

<400>  226

Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Ser Cys Ala Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  227
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild-type canine IgG-A CH1

<400>  227

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Pro Ala Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val 
        


<210>  228
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild-type canine IgG-B CH1

<400>  228

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val 
        


<210>  229
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild-type canine IgG-C CH1

<400>  229

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Gln Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Ile Pro Glu Pro Val Thr Val Ser Trp Asn Ser Val Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val 
        


<210>  230
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild-type canine IgG-D CH1

<400>  230

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Thr Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Pro Ala Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val 
        


<210>  231
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Variant canine IgG-A CH1  A(24)L S(30)D

<400>  231

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Leu Leu Ala Cys Leu Val Asp Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Pro Ala Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val 
        


<210>  232
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Variant canine IgG-B CH1  A(24)L S(30)D

<400>  232

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Leu Leu Ala Cys Leu Val Asp Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val 
        


<210>  233
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Variant canine IgG-C CH1  A(24)L S(30)D

<400>  233

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Gln Ser Gly Ser Thr Val Leu Leu Ala Cys Leu Val Asp Gly Tyr 
            20                  25                  30          


Ile Pro Glu Pro Val Thr Val Ser Trp Asn Ser Val Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val 
        


<210>  234
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Variant canine IgG-D CH1  A(24)L S(30)D

<400>  234

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Leu Leu Ala Cys Leu Val Asp Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Thr Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Pro Ala Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val 
        


<210>  235
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild-type canine kappa constant region

<400>  235

Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
1               5                   10                  15      


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
        35                  40                  45              


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser 
65                  70                  75                  80  


His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr 
                85                  90                  95      


Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
            100                 105                 110 


<210>  236
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Variant canine ? constant region  F(11)A S(22)R

<400>  236

Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Ala Gln Pro Ser Pro Asp 
1               5                   10                  15      


Gln Leu His Thr Gly Arg Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
        35                  40                  45              


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser 
65                  70                  75                  80  


His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr 
                85                  90                  95      


Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
            100                 105                 110 


<210>  237
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild-type feline IgG1 CH1

<400>  237

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val 
        


<210>  238
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild-type feline IgG2 CH1

<400>  238

Ala Ser Thr Thr Ala Ser Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu Ser Leu Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Arg Pro Ser Ser Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val 
        


<210>  239
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Variant feline IgG1 CH1  A(24)L S(30)D

<400>  239

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Leu Leu Ala Cys Leu Val Asp Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val 
        


<210>  240
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Variant feline IgG2 CH1  A(24)L S(29)D

<400>  240

Ala Ser Thr Thr Ala Ser Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Leu Leu Ala Cys Leu Asp Leu Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Arg Pro Ser Ser Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val 
        


<210>  241
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Wild-type feline ? constant region

<400>  241

Arg Ser Asp Ala Gln Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp 
1               5                   10                  15      


Glu Leu His Thr Gly Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe 
            20                  25                  30          


Tyr Pro Lys Glu Val Asn Val Lys Trp Lys Val Asp Gly Val Val Gln 
        35                  40                  45              


Asn Lys Gly Ile Gln Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln 
65                  70                  75                  80  


Ser His Glu Lys Phe Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser 
                85                  90                  95      


Thr Leu Val Lys Ser Phe Asn Arg Ser Glu Cys Gln Arg Glu 
            100                 105                 110 


<210>  242
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Variant feline ? constant region  F(11)A S(22)R

<400>  242

Arg Ser Asp Ala Gln Pro Ser Val Phe Leu Ala Gln Pro Ser Leu Asp 
1               5                   10                  15      


Glu Leu His Thr Gly Arg Ala Ser Ile Val Cys Ile Leu Asn Asp Phe 
            20                  25                  30          


Tyr Pro Lys Glu Val Asn Val Lys Trp Lys Val Asp Gly Val Val Gln 
        35                  40                  45              


Asn Lys Gly Ile Gln Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln 
65                  70                  75                  80  


Ser His Glu Lys Phe Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser 
                85                  90                  95      


Thr Leu Val Lys Ser Phe Asn Arg Ser Glu Cys Gln Arg Glu 
            100                 105                 110 


<210>  243
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable HC v2 and variant canine 
       IgG-B Fc  C1q  CD16  Bispecific Knob  Variant CH1

<400>  243

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Leu Leu Ala Cys Leu 
    130                 135                 140                 


Val Asp Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Thr Leu Trp 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  244
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable LC v2 and variant canine ? 
       constant region

<400>  244

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Asp Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Gly Val Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Leu Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Ala Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Arg Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  245
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized anti-canine IL31 Clone M14 variable HC and 
       variant canine IgG-B Fc  C1q  CD16  Bispecific Hole

<400>  245

Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
        275                 280                 285             


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Thr 
        355                 360                 365             


Leu Ser Cys Ala Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly Lys 
    450             


<210>  246
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized anti-canine IL31 Clone M14 variable LC and 
       canine ? constant region

<400>  246

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Gln Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
145                 150                 155                 160 


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
            180                 185                 190         


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
        195                 200                 205             


Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220     


<210>  247
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG1 Fc

<400>  247

Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            20                  25                  30          


Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Met Asp Gly Val Glu Val 
        35                  40                  45              


Arg Thr Ala Thr Thr Arg Pro Lys Glu Glu Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Gln Pro Ile 
                85                  90                  95      


Glu Arg Thr Ile Thr Lys Thr Lys Gly Arg Ser Gln Glu Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Ser Lys Val Ser 
        115                 120                 125             


Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asn Ile Glu 
    130                 135                 140                 


Trp Gln Ser Asn Gly Gln Pro Glu Leu Glu Thr Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Gln Ala Gln Gln Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Ser Val Asp Arg Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Gly 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Asn Val Ser 
        195                 200                 205             


Lys Asn Pro Gly Lys 
    210             


<210>  248
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG2 Fc

<400>  248

Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp 
            20                  25                  30          


Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val 
        35                  40                  45              


His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile 
                85                  90                  95      


Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser 
        115                 120                 125             


Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile Ser 
        195                 200                 205             


Glu Ser Leu Gly Lys 
    210             


<210>  249
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG3 Fc

<400>  249

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Thr Arg Met Pro Glu Val Thr Cys Leu Val Val Asp Val Ser His 
            20                  25                  30          


Asp Ser Ser Asp Val Leu Phe Thr Trp Tyr Val Asp Gly Thr Glu Val 
        35                  40                  45              


Lys Thr Ala Lys Thr Met Pro Asn Glu Glu Gln Asn Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Asn Gly 
65                  70                  75                  80  


Lys Lys Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Ser Lys Ala Thr Gly Gln Thr Arg Val Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val Ser 
        115                 120                 125             


Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Thr Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Arg Thr Thr 
145                 150                 155                 160 


Glu Ala Gln Lys Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Lys Asp Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Val 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Val Met Gln Lys Asn Ile Ser 
        195                 200                 205             


Lys Asn Pro Gly Lys 
    210             


<210>  250
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG4 Fc

<400>  250

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly His 
            20                  25                  30          


Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Thr 
        35                  40                  45              


His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Lys Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Ser Ala Pro Thr Gly Gln Pro Arg Glu Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Arg Asp Glu Leu Ser Lys Asn Lys Val Ser 
        115                 120                 125             


Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile Glu 
    130                 135                 140                 


Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Ala 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val Ser 
        195                 200                 205             


Lys Ser Pro Gly Lys 
    210             


<210>  251
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG5 Fc

<400>  251

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Ser Arg Lys Pro Glu Val Thr Cys Val Val Val Asp Leu Gly His 
            20                  25                  30          


Asp Asp Pro Asp Val Gln Phe Thr Trp Phe Val Asp Gly Val Glu Thr 
        35                  40                  45              


His Thr Ala Thr Thr Glu Pro Lys Glu Glu Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Ser Val Thr Ser Lys Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Leu Arg Val Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ala Lys Asn Thr Val Ser 
        115                 120                 125             


Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asn Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Ser Val Glu Thr Ser Arg Trp Lys Gln Gly Glu Ser Phe Thr Cys Gly 
            180                 185                 190         


Val Met His Glu Ala Val Glu Asn His Tyr Thr Gln Lys Asn Val Ser 
        195                 200                 205             


His Ser Pro Gly Lys 
    210             


<210>  252
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG6 Fc

<400>  252

Gly Arg Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Ala His Thr Ala Thr Thr Lys Ala Lys Glu Lys Gln Asp Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Arg Arg 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Thr Lys Ala Lys Gly Glu Leu Gln Asp Pro Lys 
            100                 105                 110         


Val Tyr Ile Leu Ala Pro His Arg Glu Glu Val Thr Lys Asn Thr Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asn Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu Glu Pro Glu Pro Glu Val Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asp Arg Trp Glu Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Val Val Met His Glu Ala Ile Arg His Thr Tyr Arg Gln Lys Ser Ile 
        195                 200                 205             


Thr Asn Phe Pro Gly Lys 
    210                 


<210>  253
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG7 Fc

<400>  253

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly His 
            20                  25                  30          


Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Thr 
        35                  40                  45              


His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Asn Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Ile Leu Ala Ile Gln His Lys Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Gln Lys Thr Ile Ser Lys Pro Thr Gly Gln Pro Arg Glu Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val Ser 
        115                 120                 125             


Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile Glu 
    130                 135                 140                 


Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Ala 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val Ser 
        195                 200                 205             


Lys Ser Pro Gly Lys 
    210             


<210>  254
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG1 Fc  Bispecific knob 
       T(130)W

<400>  254

Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            20                  25                  30          


Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Met Asp Gly Val Glu Val 
        35                  40                  45              


Arg Thr Ala Thr Thr Arg Pro Lys Glu Glu Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Gln Pro Ile 
                85                  90                  95      


Glu Arg Thr Ile Thr Lys Thr Lys Gly Arg Ser Gln Glu Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Ser Lys Val Ser 
        115                 120                 125             


Val Trp Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asn Ile Glu 
    130                 135                 140                 


Trp Gln Ser Asn Gly Gln Pro Glu Leu Glu Thr Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Gln Ala Gln Gln Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Ser Val Asp Arg Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Gly 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Asn Val Ser 
        195                 200                 205             


Lys Asn Pro Gly Lys 
    210             


<210>  255
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc  Bispecific knob 
       T(130)W

<400>  255

Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp 
            20                  25                  30          


Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val 
        35                  40                  45              


His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile 
                85                  90                  95      


Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser 
        115                 120                 125             


Val Trp Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile Ser 
        195                 200                 205             


Glu Ser Leu Gly Lys 
    210             


<210>  256
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG3 Fc  Bispecific knob 
       T(130)W

<400>  256

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Thr Arg Met Pro Glu Val Thr Cys Leu Val Val Asp Val Ser His 
            20                  25                  30          


Asp Ser Ser Asp Val Leu Phe Thr Trp Tyr Val Asp Gly Thr Glu Val 
        35                  40                  45              


Lys Thr Ala Lys Thr Met Pro Asn Glu Glu Gln Asn Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Asn Gly 
65                  70                  75                  80  


Lys Lys Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Ser Lys Ala Thr Gly Gln Thr Arg Val Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val Ser 
        115                 120                 125             


Val Trp Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Thr Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Arg Thr Thr 
145                 150                 155                 160 


Glu Ala Gln Lys Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Lys Asp Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Val 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Val Met Gln Lys Asn Ile Ser 
        195                 200                 205             


Lys Asn Pro Gly Lys 
    210             


<210>  257
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG4 Fc  Bispecific knob 
       T(130)W

<400>  257

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly His 
            20                  25                  30          


Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Thr 
        35                  40                  45              


His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Lys Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Ser Ala Pro Thr Gly Gln Pro Arg Glu Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Arg Asp Glu Leu Ser Lys Asn Lys Val Ser 
        115                 120                 125             


Val Trp Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile Glu 
    130                 135                 140                 


Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Ala 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val Ser 
        195                 200                 205             


Lys Ser Pro Gly Lys 
    210             


<210>  258
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG5 Fc  Bispecific knob 
       T(130)W

<400>  258

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Ser Arg Lys Pro Glu Val Thr Cys Val Val Val Asp Leu Gly His 
            20                  25                  30          


Asp Asp Pro Asp Val Gln Phe Thr Trp Phe Val Asp Gly Val Glu Thr 
        35                  40                  45              


His Thr Ala Thr Thr Glu Pro Lys Glu Glu Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Ser Val Thr Ser Lys Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Leu Arg Val Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ala Lys Asn Thr Val Ser 
        115                 120                 125             


Val Trp Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asn Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Ser Val Glu Thr Ser Arg Trp Lys Gln Gly Glu Ser Phe Thr Cys Gly 
            180                 185                 190         


Val Met His Glu Ala Val Glu Asn His Tyr Thr Gln Lys Asn Val Ser 
        195                 200                 205             


His Ser Pro Gly Lys 
    210             


<210>  259
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG6 Fc  Bispecific knob 
       T(130)W

<400>  259

Arg Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            20                  25                  30          


Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Ala 
        35                  40                  45              


His Thr Ala Thr Thr Lys Ala Lys Glu Lys Gln Asp Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Arg Arg Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Thr Lys Ala Lys Gly Glu Leu Gln Asp Pro Lys Val 
            100                 105                 110         


Tyr Ile Leu Ala Pro His Arg Glu Glu Val Thr Lys Asn Thr Val Ser 
        115                 120                 125             


Val Trp Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asn Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Glu Glu Pro Glu Pro Glu Val Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Thr Asp Arg Trp Glu Gln Gly Glu Ser Phe Thr Cys Val 
            180                 185                 190         


Val Met His Glu Ala Ile Arg His Thr Tyr Arg Gln Lys Ser Ile Thr 
        195                 200                 205             


Asn Phe Pro Gly Lys 
    210             


<210>  260
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG7 Fc  Bispecific knob 
       T(130)W

<400>  260

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly His 
            20                  25                  30          


Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Thr 
        35                  40                  45              


His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Asn Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Ile Leu Ala Ile Gln His Lys Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Gln Lys Thr Ile Ser Lys Pro Thr Gly Gln Pro Arg Glu Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val Ser 
        115                 120                 125             


Val Trp Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile Glu 
    130                 135                 140                 


Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Ala 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val Ser 
        195                 200                 205             


Lys Ser Pro Gly Lys 
    210             


<210>  261
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG1 Fc  Bispecific hole 
       T(130)S L(132)A

<400>  261

Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            20                  25                  30          


Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Met Asp Gly Val Glu Val 
        35                  40                  45              


Arg Thr Ala Thr Thr Arg Pro Lys Glu Glu Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Gln Pro Ile 
                85                  90                  95      


Glu Arg Thr Ile Thr Lys Thr Lys Gly Arg Ser Gln Glu Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Ser Lys Val Ser 
        115                 120                 125             


Val Ser Cys Ala Val Lys Asp Phe Tyr Pro Pro Glu Ile Asn Ile Glu 
    130                 135                 140                 


Trp Gln Ser Asn Gly Gln Pro Glu Leu Glu Thr Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Gln Ala Gln Gln Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Ser Val Asp Arg Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Gly 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Asn Val Ser 
        195                 200                 205             


Lys Asn Pro Gly Lys 
    210             


<210>  262
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc  Bispecific hole 
       T(130)S L(132)A

<400>  262

Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp 
            20                  25                  30          


Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val 
        35                  40                  45              


His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile 
                85                  90                  95      


Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser 
        115                 120                 125             


Val Ser Cys Ala Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile Ser 
        195                 200                 205             


Glu Ser Leu Gly Lys 
    210             


<210>  263
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG3 Fc  Bispecific hole 
       T(130)S L(132)A

<400>  263

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Thr Arg Met Pro Glu Val Thr Cys Leu Val Val Asp Val Ser His 
            20                  25                  30          


Asp Ser Ser Asp Val Leu Phe Thr Trp Tyr Val Asp Gly Thr Glu Val 
        35                  40                  45              


Lys Thr Ala Lys Thr Met Pro Asn Glu Glu Gln Asn Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Asn Gly 
65                  70                  75                  80  


Lys Lys Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Ser Lys Ala Thr Gly Gln Thr Arg Val Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val Ser 
        115                 120                 125             


Val Ser Cys Ala Val Lys Asp Phe Tyr Pro Pro Asp Ile Thr Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Arg Thr Thr 
145                 150                 155                 160 


Glu Ala Gln Lys Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Lys Asp Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Val 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Val Met Gln Lys Asn Ile Ser 
        195                 200                 205             


Lys Asn Pro Gly Lys 
    210             


<210>  264
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG4 Fc  Bispecific hole 
       T(130)S L(132)A

<400>  264

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly His 
            20                  25                  30          


Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Thr 
        35                  40                  45              


His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Lys Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Ser Ala Pro Thr Gly Gln Pro Arg Glu Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Arg Asp Glu Leu Ser Lys Asn Lys Val Ser 
        115                 120                 125             


Val Ser Cys Ala Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile Glu 
    130                 135                 140                 


Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Ala 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val Ser 
        195                 200                 205             


Lys Ser Pro Gly Lys 
    210             


<210>  265
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG5 Fc  Bispecific hole 
       T(130)S L(132)A

<400>  265

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Ser Arg Lys Pro Glu Val Thr Cys Val Val Val Asp Leu Gly His 
            20                  25                  30          


Asp Asp Pro Asp Val Gln Phe Thr Trp Phe Val Asp Gly Val Glu Thr 
        35                  40                  45              


His Thr Ala Thr Thr Glu Pro Lys Glu Glu Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Ser Val Thr Ser Lys Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Leu Arg Val Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ala Lys Asn Thr Val Ser 
        115                 120                 125             


Val Ser Cys Ala Val Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asn Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Ser Val Glu Thr Ser Arg Trp Lys Gln Gly Glu Ser Phe Thr Cys Gly 
            180                 185                 190         


Val Met His Glu Ala Val Glu Asn His Tyr Thr Gln Lys Asn Val Ser 
        195                 200                 205             


His Ser Pro Gly Lys 
    210             


<210>  266
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG6 Fc  Bispecific hole 
       T(130)S L(132)A

<400>  266

Arg Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            20                  25                  30          


Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Ala 
        35                  40                  45              


His Thr Ala Thr Thr Lys Ala Lys Glu Lys Gln Asp Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Arg Arg Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Glu Arg Thr Ile Thr Lys Ala Lys Gly Glu Leu Gln Asp Pro Lys Val 
            100                 105                 110         


Tyr Ile Leu Ala Pro His Arg Glu Glu Val Thr Lys Asn Thr Val Ser 
        115                 120                 125             


Val Ser Cys Ala Val Lys Asp Phe Tyr Pro Pro Asp Ile Asn Val Glu 
    130                 135                 140                 


Trp Gln Ser Asn Glu Glu Pro Glu Pro Glu Val Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Thr Asp Arg Trp Glu Gln Gly Glu Ser Phe Thr Cys Val 
            180                 185                 190         


Val Met His Glu Ala Ile Arg His Thr Tyr Arg Gln Lys Ser Ile Thr 
        195                 200                 205             


Asn Phe Pro Gly Lys 
    210             


<210>  267
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG7 Fc  Bispecific hole 
       T(130)S L(132)A

<400>  267

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly His 
            20                  25                  30          


Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Thr 
        35                  40                  45              


His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Asn Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Ile Leu Ala Ile Gln His Lys Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Ala Pro Val 
                85                  90                  95      


Gln Lys Thr Ile Ser Lys Pro Thr Gly Gln Pro Arg Glu Pro Gln Val 
            100                 105                 110         


Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val Ser 
        115                 120                 125             


Val Ser Cys Ala Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile Glu 
    130                 135                 140                 


Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr Thr 
145                 150                 155                 160 


Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys Ala 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val Ser 
        195                 200                 205             


Lys Ser Pro Gly Lys 
    210             


<210>  268
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Alternative CDR-H2


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X is K or A

<400>  268

Tyr Ile Asn Pro Xaa Asn Asp Gly Thr 
1               5                   


<210>  269
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Alternative Clone B CDR-H2

<400>  269

Tyr Ile Asn Pro Lys Asn Asp Gly Thr 
1               5                   


<210>  270
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Alternative Clone B  HC-FR3

<400>  270

Phe Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys Ala Ala 
        35                  40  


<210>  271
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Alternative Clone I CDR-H2

<400>  271

Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  272
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Alternative Clone I CDR-H2

<400>  272

Tyr Ile Asn Pro Asn Asn Asp Gly Thr 
1               5                   


<210>  273
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Alternative Clone I HC-FR3

<400>  273

Phe Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys Ala Ala 
        35                  40  


<210>  274
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable HC v3

<400>  274

Glu Val Gln Leu Val Gln Ser Ala Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Gly Thr Thr Tyr 
65                  70                  75                  80  


Thr Glu Leu Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  275
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable LC v3

<400>  275

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Gly Val Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  276
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable HC v3 and  variant canine 
       IgG-B  C1q , CD16

<400>  276

Glu Val Gln Leu Val Gln Ser Ala Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Asp Gly Thr Phe Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Gly Thr Thr Tyr 
65                  70                  75                  80  


Thr Glu Leu Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  277
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone I variable LC v3 and canine ? light 
       constant region

<400>  277

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Gly Val Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Leu Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  278
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 CDR-H1

<400>  278

Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr Ser Val His 
1               5                   10              


<210>  279
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 CDR-H2

<400>  279

Gly Met Ile Trp Gly Gly Gly Ser Thr 
1               5                   


<210>  280
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 CDR-H3

<400>  280

Thr Tyr Arg Gly Tyr Ala Leu Asp Tyr 
1               5                   


<210>  281
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 HC-FR1

<400>  281

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys 
            20          


<210>  282
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 HC-FR2

<400>  282

Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
1               5                   10              


<210>  283
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 HC-FR3

<400>  283

Asp Tyr Asn Ser Val Phe Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn 
1               5                   10                  15      


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            20                  25                  30          


Thr Ala Met Tyr Tyr Cys Ala Arg 
        35                  40  


<210>  284
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 HC-FR4

<400>  284

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  285
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 CDR-L1

<400>  285

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  286
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 CDR-L2

<400>  286

Tyr Tyr Thr Ser Arg Leu Gln Ser 
1               5               


<210>  287
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 CDR-L3

<400>  287

Gln Gln Ala Asn Thr Leu Pro Leu Thr 
1               5                   


<210>  288
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 LC-FR1

<400>  288

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  289
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 LC-FR2

<400>  289

Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
1               5                   10                  


<210>  290
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 LC-FR3

<400>  290

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Cys 
1               5                   10                  15      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  291
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 LC-FR4

<400>  291

Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  292
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 variable HC

<400>  292

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Val Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Tyr Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  293
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M3 variable LC

<400>  293

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Cys Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ala Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  294
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 CDR-H1

<400>  294

Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr Ser Val His 
1               5                   10              


<210>  295
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 CDR-H2

<400>  295

Gly Met Ile Trp Gly Gly Gly Ser Thr 
1               5                   


<210>  296
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 CDR-H3

<400>  296

Thr Tyr Arg Gly Tyr Ala Leu Asp Tyr 
1               5                   


<210>  297
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 HC-FR1

<400>  297

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys 
            20          


<210>  298
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 HC-FR2

<400>  298

Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
1               5                   10              


<210>  299
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 HC-FR3

<400>  299

Asp Tyr Asn Ser Val Phe Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn 
1               5                   10                  15      


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            20                  25                  30          


Thr Ala Met Tyr Tyr Cys Ala Arg 
        35                  40  


<210>  300
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 HC-FR4

<400>  300

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  301
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 CDR-L1

<400>  301

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  302
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 CDR-L2

<400>  302

Tyr Tyr Thr Ser Arg Leu Gln Ser 
1               5               


<210>  303
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 CDR-L3

<400>  303

Gln Gln Ala Asn Thr Leu Pro Leu Thr 
1               5                   


<210>  304
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 LC-FR1

<400>  304

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  305
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 LC-FR2

<400>  305

Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
1               5                   10                  


<210>  306
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 LC-FR3

<400>  306

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Cys 
1               5                   10                  15      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  307
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 LC-FR4

<400>  307

Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  308
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 variable HC

<400>  308

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Val Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Tyr Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  309
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M5 variable LC

<400>  309

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Cys Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ala Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  310
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 CDR-H1

<400>  310

Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asp Ile Asn 
1               5                   10              


<210>  311
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 CDR-H2

<400>  311

Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys 
1               5                   10      


<210>  312
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 CDR-H3

<400>  312

Ser Ser Phe Val Val 
1               5   


<210>  313
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 HC-FR1

<400>  313

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Ile Ser Cys 
            20          


<210>  314
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 HC-FR2

<400>  314

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
1               5                   10              


<210>  315
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 HC-FR3

<400>  315

Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
1               5                   10                  15      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            20                  25                  30          


Ala Val Tyr Phe Cys Ala Arg 
        35                  


<210>  316
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 HC-FR4

<400>  316

Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  317
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 CDR-L1

<400>  317

Lys Ala Ser Asp Pro Ile Asn Asn Trp Leu Ala 
1               5                   10      


<210>  318
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 CDR-L2

<400>  318

Ser Gly Ala Thr Ser Leu Glu Thr 
1               5               


<210>  319
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 CDR-L3

<400>  319

His Gln Tyr Trp Ser Ile Pro Tyr Thr 
1               5                   


<210>  320
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 LC-FR1

<400>  320

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys 
            20              


<210>  321
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 LC-FR2

<400>  321

Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
1               5                   10                  


<210>  322
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 LC-FR3

<400>  322

Gly Val Pro Ser Arg Ile Ser Gly Ser Gly Ser Gly Lys Asp Tyr Ser 
1               5                   10                  15      


Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  323
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 LC-FR4

<400>  323

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  324
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 variable HC

<400>  324

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ser Phe Val Val Trp Gly Ala Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  325
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M8 variable LC

<400>  325

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp Pro Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Ile Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Ser Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Trp Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  326
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 CDR-H1

<400>  326

Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met His 
1               5                   10              


<210>  327
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 CDR-H2

<400>  327

Ala Tyr Ile Arg Ser Asp Ser Ser Thr Ile Tyr 
1               5                   10      


<210>  328
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 CDR-H3

<400>  328

Ser Gly Tyr Tyr Gly Ser Phe Ser Leu Thr Tyr 
1               5                   10      


<210>  329
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 HC-FR1

<400>  329

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys 
            20          


<210>  330
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 HC-FR2

<400>  330

Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
1               5                   10              


<210>  331
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 HC-FR3

<400>  331

Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro 
1               5                   10                  15      


Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr 
            20                  25                  30          


Ala Met Tyr Tyr Cys Ala Arg 
        35                  


<210>  332
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 HC-FR4

<400>  332

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  333
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 CDR-L1

<400>  333

Ser Ala Ser Ser Ser Val Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  334
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 CDR-L2

<400>  334

Tyr Arg Thr Ser Asn Leu Pro Ser 
1               5               


<210>  335
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 CDR-L3

<400>  335

Gln Gln Gly Ser Gly Met Leu Thr 
1               5               


<210>  336
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 LC-FR1

<400>  336

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys 
            20              


<210>  337
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 LC-FR2

<400>  337

Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu Ile 
1               5                   10                  


<210>  338
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 LC-FR3

<400>  338

Gly Val Pro Ala Arg Phe Phe Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Gly Thr Met Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  339
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 LC-FR4

<400>  339

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  340
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 variable HC

<400>  340

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Arg Ser Asp Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Phe Ser Leu Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  341
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Clone M9 variable LC

<400>  341

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Pro Ser Gly Val Pro Ala Arg Phe Phe 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Gly Met Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  342
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M3 variable HC v1

<400>  342

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Ala Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Val Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Tyr Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  343
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M3 variable HC v2

<400>  343

Glu Leu Thr Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val His Trp Ile Arg Gln Pro Arg Gly Arg Gly Leu Glu Leu Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Pro Ala Phe Gln 
    50                  55                  60                  


Gly Arg Ile Ser Ile Thr Ala Asp Thr Ala Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Met Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Tyr Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  344
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M3 variable LC v1

<400>  344

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Leu Gln Lys Ala Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Val Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Gly Ile Tyr Phe Cys Gln Gln Ala Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Val Arg 
            100                 105         


<210>  345
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M9 variable HC v1

<400>  345

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Arg Ser Asp Ser Ser Thr Ile Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Phe Ser Leu Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  346
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M9 variable HC v2

<400>  346

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Tyr Ile Arg Ser Asp Ser Ser Thr Ile Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Phe Ser Leu Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  347
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M9 variable LC v1

<400>  347

Asp Ile Met Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Leu Gln Lys Ala Gly Gln Ser Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Gly Ile Tyr Tyr Cys Gln Gln Gly Ser Gly Met Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Val Arg 
            100                 105         


<210>  348
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M3 variable HC v1 and  variant canine 
       IgG-B  C1q , CD16

<400>  348

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Ala Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Ser Val Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Tyr Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys 
    130                 135                 140                 


Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg 
            180                 185                 190         


Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys 
        195                 200                 205             


Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro 
    210                 215                 220                 


Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
                245                 250                 255     


Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys 
305                 310                 315                 320 


Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp 
    370                 375                 380                 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro 
385                 390                 395                 400 


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  349
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M3 variable HC v2 and  variant canine 
       IgG-B  C1q , CD16

<400>  349

Glu Leu Thr Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val His Trp Ile Arg Gln Pro Arg Gly Arg Gly Leu Glu Leu Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Pro Ala Phe Gln 
    50                  55                  60                  


Gly Arg Ile Ser Ile Thr Ala Asp Thr Ala Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Met Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Tyr Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys 
    130                 135                 140                 


Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg 
            180                 185                 190         


Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys 
        195                 200                 205             


Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro 
    210                 215                 220                 


Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
                245                 250                 255     


Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Arg Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys 
305                 310                 315                 320 


Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp 
    370                 375                 380                 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro 
385                 390                 395                 400 


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  350
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M3 variable LC v1 and canine ? light 
       constant region

<400>  350

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Leu Gln Lys Ala Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Val Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Gly Ile Tyr Phe Cys Gln Gln Ala Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Val Arg Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  351
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M9 variable HC v1 and  variant canine 
       IgG-B  C1q , CD16

<400>  351

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Arg Ser Asp Ser Ser Thr Ile Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Phe Ser Leu Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  352
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M9 variable HC v2 and  variant canine 
       IgG-B  C1q , CD16

<400>  352

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Tyr Ile Arg Ser Asp Ser Ser Thr Ile Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Phe Ser Leu Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Pro 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  353
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized Clone M9 variable LC v1 and canine ? light 
       constant region

<400>  353

Asp Ile Met Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Leu Gln Lys Ala Gly Gln Ser Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Gly Arg Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Gly Ile Tyr Tyr Cys Gln Gln Gly Ser Gly Met Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Val Arg Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  354
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: M3 canine IL4R epitope

<400>  354

Asp Phe Met Gly Ser Glu Asn His Thr Cys Val Pro Glu Asn 
1               5                   10                  


<210>  355
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: M8 canine IL4R   epitope 1

<400>  355

Gly Ser Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile 
1               5                   10                  15      


Ser Thr Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser 
            20                  25                  30          


Ala 
    


<210>  356
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: M8 canine IL4R   epitope 2

<400>  356

Arg Glu Asp Ser Val Cys Val Cys Ser Met Pro Ile 
1               5                   10          


<210>  357
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: M9 canine IL4R epitope

<400>  357

Arg Glu Asp Ser Val Cys Val Cys Ser Met Pro Ile Asp Asp Ala Val 
1               5                   10                  15      


Glu Ala Asp Val 
            20  


