                         SEQUENCE LISTING

<110>  Children's National Medical Center
       The George Washington University
       Cruz, Conrad Russell Y.
       Powell, Allison  `
       Jones, Brad
       Nixon, Douglas
       Bollard, Catherine
 
<120>  CELLS COMPRISING ANTIBODIES AGAINST HUMAN IMMUNODEFICIENCY VIRUS 
       AND METHODS OF USING THE SAME

<130>  37921.0016P1

<150>  62/730,922
<151>  2018-09-13

<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  4444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PG9 Full length Antibody- nucleic acid

<400>  1
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccatcggct      600

cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt      660

cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt      720

ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc      780

agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttaac ggtggagggc      840

agtgtagtct gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag      900

actaacagac tgttcctttc catgggtctt ttctgcagtc accgtcgtcg acacgtgtga      960

tcagatatcg cggccgctct agaccaccat gggatggtca tgtatcatcc tttttctagt     1020

agcaactgca accggtgtac attcacagtc tgccctgact cagcctgcct ccgtgtctgg     1080

gtctcctgga cagtcgatca ccatctcctg caatggaacc agcaatgatg ttggtggcta     1140

tgaatctgtc tcctggtacc aacaacatcc cggcaaagcc cccaaagtcg tgatttatga     1200

tgtcagtaaa cggccctcag gggtttctaa tcgcttctct ggctccaagt ccggcaacac     1260

ggcctccctg accatctctg ggctccaggc tgaggacgag ggtgactatt actgcaagtc     1320

tctgacaagc acgagacgtc gggttttcgg cactgggacc aagctgaccg ttctaaccgt     1380

ggcggcgccg agcgtgttta tttttccgcc gagcgatgaa cagctgaaaa gcggcaccgc     1440

gagcgtggtg tgcctgctga acaactttta tccgcgcgaa gcgaaagtgc agtggaaagt     1500

ggataacgcg ctgcagagcg gcaacagcca ggaaagcgtg accgaacagg atagcaaaga     1560

tagcacctat agcctgagca gcaccctgac cctgagcaaa gcggattatg aaaaacataa     1620

agtgtatgcg tgcgaagtga cccatcaggg cctgagcagc ccggtgacca aaagctttaa     1680

ccgcggcgaa tgccgcaaac gccgcggcag cggcgcgacc aactttagcc tgctgaaaca     1740

ggcgggcgat gtggaagaaa acccgggccc gatgggatgg tcatgtatca tcctttttct     1800

agtagcaact gcaaccggtg tacattcaca gcgattagtg gagtctgggg gaggcgtggt     1860

ccagcctggg tcgtccctga gactctcctg tgcagcgtcc ggattcgact tcagtagaca     1920

aggcatgcac tgggtccgcc aggctccagg ccaggggctg gagtgggtgg catttattaa     1980

atatgatgga agtgagaaat atcatgctga ctccgtatgg ggccgactca gcatctccag     2040

agacaattcc aaggatacgc tttatctcca aatgaatagc ctgagagtcg aggacacggc     2100

tacatatttt tgtgtgagag aggctggtgg gcccgactac cgtaatgggt acaactatta     2160

cgatttctat gatggttatt ataactacca ctatatggac gtctggggca aagggaccac     2220

ggtcaccgtc tcgagcgcga gcaccaaagg cccgagcgtg tttccgctgg cgccgtgcag     2280

ccgcagcacc agcggcggca ccgcggcgct gggctgcctg gtgaaagatt attttccgga     2340

accggtgacc gtgagctgga acagcggcgc gctgaccagc ggcgtgcata cctttccggc     2400

ggtgctgcag agcagcggcc tgtatagcct gagcagcgtg gtgaccgtgc cgagcagcag     2460

cctgggcacc cagacctata cctgcaacgt gaaccataaa ccgagcaaca ccaaagtgga     2520

taaacgcgtg gaactgaaaa ccccgctggg cgataccacc catacctgcc cgcgctgccc     2580

ggaaccgaaa agctgcgata ccccgccgcc gtgcccgcgc tgcccggaac cgaaaagctg     2640

cgataccccg ccgccgtgcc cgcgctgccc ggaaccgaaa agctgcgata ccccgccgcc     2700

gtgcccgcgc tgcccggcgc cggaactgct gggcggcccg agcgtgtttc tgtttccgcc     2760

gaaaccgaaa gataccctga tgattagccg caccccggaa gtgacctgcg tggtggtgga     2820

tgtgagccat gaagatccgg aagtgcagtt taaatggtat gtggatggcg tggaagtgca     2880

taacgcgaaa accaaaccgc gcgaagaaca gtataacagc acctttcgcg tggtgagcgt     2940

gctgaccgtg ctgcatcagg attggctgaa cggcaaagaa tataaatgca aagtgagcaa     3000

caaagcgctg ccggcgccga ttgaaaaaac cattagcaaa accaaaggcc agccgcgcga     3060

accgcaggtg tataccctgc cgccgagccg cgaagaaatg accaaaaacc aggtgagcct     3120

gacctgcctg gtgaaaggct tttatccgag cgatattgcg gtggaatggg aaagcagcgg     3180

ccagccggaa aacaactata acaccacccc gccgatgctg gatagcgatg gcagcttttt     3240

tctgtatagc aaactgaccg tggataaaag ccgctggcag cagggcaaca tttttagctg     3300

cagcgtgatg catgaagcgc tgcataaccg ctttacccag aaaagcctga gcctgagccc     3360

gggcaaacgc aaacgccgcg gcagcggcgc gaccaacttt agcctgctga aacaggcggg     3420

cgatgtggaa gaaaacccgg gcccgatgcc acctcctcgc ctcctcttct tcctcctctt     3480

cctcaccccc atggaagtca ggcccgagga acctctagtg gtgaaggtgg aagagggaga     3540

taacgctgtg ctgcagtgcc tcaaggggac ctcagatggc cccactcagc agctgacctg     3600

gtctcgggag tccccgctta aacccttctt aaaactcagc ctggggctgc caggcctggg     3660

aatccacatg aggcccctgg ccatctggct tttcatcttc aacgtctctc aacagatggg     3720

gggcttctac ctgtgccagc cggggccccc ctctgagaag gcctggcagc ctggctggac     3780

agtcaatgtg gagggcagcg gggagctgtt ccggtggaat gtttcggacc taggtggcct     3840

gggctgtggc ctgaagaaca ggtcctcaga gggccccagc tccccttccg ggaagctcat     3900

gagccccaag ctgtatgtgt gggccaaaga ccgccctgag atctgggagg gagagcctcc     3960

gtgtctccca ccgagggaca gcctgaacca gagcctcagc caggacctca ccatggcccc     4020

tggctccaca ctctggctgt cctgtggggt accccctgac tctgtgtcca ggggccccct     4080

ctcctggacc catgtgcacc ccaaggggcc taagtcattg ctgagcctag agctgaagga     4140

cgatcgcccg gccagagata tgtgggtaat ggagacgggt ctgttgttgc cccgggccac     4200

agctcaagac gctggaaagt attattgtca ccgtggcaac ctgaccatgt cattccacct     4260

ggagatcact gctcggccag tactatggca ctggctgctg aggactggtg gctggaaggt     4320

ctcagctgtg actttggctt atctgatctt ctgcctgtgt tcccttgtgg gcattcttca     4380

tcttcaaaga gccctggtcc tgaggaggaa aagaaagcga atgactgacc ccaccaggag     4440

attc                                                                  4444


<210>  2
<211>  3456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G9 Full length Antibody- nucleic acid encoded region

<400>  2
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcacag       60

tctgccctga ctcagcctgc ctccgtgtct gggtctcctg gacagtcgat caccatctcc      120

tgcaatggaa ccagcaatga tgttggtggc tatgaatctg tctcctggta ccaacaacat      180

cccggcaaag cccccaaagt cgtgatttat gatgtcagta aacggccctc aggggtttct      240

aatcgcttct ctggctccaa gtccggcaac acggcctccc tgaccatctc tgggctccag      300

gctgaggacg agggtgacta ttactgcaag tctctgacaa gcacgagacg tcgggttttc      360

ggcactggga ccaagctgac cgttctaacc gtggcggcgc cgagcgtgtt tatttttccg      420

ccgagcgatg aacagctgaa aagcggcacc gcgagcgtgg tgtgcctgct gaacaacttt      480

tatccgcgcg aagcgaaagt gcagtggaaa gtggataacg cgctgcagag cggcaacagc      540

caggaaagcg tgaccgaaca ggatagcaaa gatagcacct atagcctgag cagcaccctg      600

accctgagca aagcggatta tgaaaaacat aaagtgtatg cgtgcgaagt gacccatcag      660

ggcctgagca gcccggtgac caaaagcttt aaccgcggcg aatgccgcaa acgccgcggc      720

agcggcgcga ccaactttag cctgctgaaa caggcgggcg atgtggaaga aaacccgggc      780

ccgatgggat ggtcatgtat catccttttt ctagtagcaa ctgcaaccgg tgtacattca      840

cagcgattag tggagtctgg gggaggcgtg gtccagcctg ggtcgtccct gagactctcc      900

tgtgcagcgt ccggattcga cttcagtaga caaggcatgc actgggtccg ccaggctcca      960

ggccaggggc tggagtgggt ggcatttatt aaatatgatg gaagtgagaa atatcatgct     1020

gactccgtat ggggccgact cagcatctcc agagacaatt ccaaggatac gctttatctc     1080

caaatgaata gcctgagagt cgaggacacg gctacatatt tttgtgtgag agaggctggt     1140

gggcccgact accgtaatgg gtacaactat tacgatttct atgatggtta ttataactac     1200

cactatatgg acgtctgggg caaagggacc acggtcaccg tctcgagcgc gagcaccaaa     1260

ggcccgagcg tgtttccgct ggcgccgtgc agccgcagca ccagcggcgg caccgcggcg     1320

ctgggctgcc tggtgaaaga ttattttccg gaaccggtga ccgtgagctg gaacagcggc     1380

gcgctgacca gcggcgtgca tacctttccg gcggtgctgc agagcagcgg cctgtatagc     1440

ctgagcagcg tggtgaccgt gccgagcagc agcctgggca cccagaccta tacctgcaac     1500

gtgaaccata aaccgagcaa caccaaagtg gataaacgcg tggaactgaa aaccccgctg     1560

ggcgatacca cccatacctg cccgcgctgc ccggaaccga aaagctgcga taccccgccg     1620

ccgtgcccgc gctgcccgga accgaaaagc tgcgataccc cgccgccgtg cccgcgctgc     1680

ccggaaccga aaagctgcga taccccgccg ccgtgcccgc gctgcccggc gccggaactg     1740

ctgggcggcc cgagcgtgtt tctgtttccg ccgaaaccga aagataccct gatgattagc     1800

cgcaccccgg aagtgacctg cgtggtggtg gatgtgagcc atgaagatcc ggaagtgcag     1860

tttaaatggt atgtggatgg cgtggaagtg cataacgcga aaaccaaacc gcgcgaagaa     1920

cagtataaca gcacctttcg cgtggtgagc gtgctgaccg tgctgcatca ggattggctg     1980

aacggcaaag aatataaatg caaagtgagc aacaaagcgc tgccggcgcc gattgaaaaa     2040

accattagca aaaccaaagg ccagccgcgc gaaccgcagg tgtataccct gccgccgagc     2100

cgcgaagaaa tgaccaaaaa ccaggtgagc ctgacctgcc tggtgaaagg cttttatccg     2160

agcgatattg cggtggaatg ggaaagcagc ggccagccgg aaaacaacta taacaccacc     2220

ccgccgatgc tggatagcga tggcagcttt tttctgtata gcaaactgac cgtggataaa     2280

agccgctggc agcagggcaa catttttagc tgcagcgtga tgcatgaagc gctgcataac     2340

cgctttaccc agaaaagcct gagcctgagc ccgggcaaac gcaaacgccg cggcagcggc     2400

gcgaccaact ttagcctgct gaaacaggcg ggcgatgtgg aagaaaaccc gggcccgatg     2460

ccacctcctc gcctcctctt cttcctcctc ttcctcaccc ccatggaagt caggcccgag     2520

gaacctctag tggtgaaggt ggaagaggga gataacgctg tgctgcagtg cctcaagggg     2580

acctcagatg gccccactca gcagctgacc tggtctcggg agtccccgct taaacccttc     2640

ttaaaactca gcctggggct gccaggcctg ggaatccaca tgaggcccct ggccatctgg     2700

cttttcatct tcaacgtctc tcaacagatg gggggcttct acctgtgcca gccggggccc     2760

ccctctgaga aggcctggca gcctggctgg acagtcaatg tggagggcag cggggagctg     2820

ttccggtgga atgtttcgga cctaggtggc ctgggctgtg gcctgaagaa caggtcctca     2880

gagggcccca gctccccttc cgggaagctc atgagcccca agctgtatgt gtgggccaaa     2940

gaccgccctg agatctggga gggagagcct ccgtgtctcc caccgaggga cagcctgaac     3000

cagagcctca gccaggacct caccatggcc cctggctcca cactctggct gtcctgtggg     3060

gtaccccctg actctgtgtc caggggcccc ctctcctgga cccatgtgca ccccaagggg     3120

cctaagtcat tgctgagcct agagctgaag gacgatcgcc cggccagaga tatgtgggta     3180

atggagacgg gtctgttgtt gccccgggcc acagctcaag acgctggaaa gtattattgt     3240

caccgtggca acctgaccat gtcattccac ctggagatca ctgctcggcc agtactatgg     3300

cactggctgc tgaggactgg tggctggaag gtctcagctg tgactttggc ttatctgatc     3360

ttctgcctgt gttcccttgt gggcattctt catcttcaaa gagccctggt cctgaggagg     3420

aaaagaaagc gaatgactga ccccaccagg agattc                               3456


<210>  3
<211>  2770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PG9 light chain nucleic acid sequence

<400>  3
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccatcggct      600

cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt      660

cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt      720

ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc      780

agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttaac ggtggagggc      840

agtgtagtct gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag      900

actaacagac tgttcctttc catgggtctt ttctgcagtc accgtcgtcg acacgtgtga      960

tcagatatcg cggccgctct agaccaccat gggatggtca tgtatcatcc tttttctagt     1020

agcaactgca accggtgtac attcacagtc tgccctgact cagcctgcct ccgtgtctgg     1080

gtctcctgga cagtcgatca ccatctcctg caatggaacc agcaatgatg ttggtggcta     1140

tgaatctgtc tcctggtacc aacaacatcc cggcaaagcc cccaaagtcg tgatttatga     1200

tgtcagtaaa cggccctcag gggtttctaa tcgcttctct ggctccaagt ccggcaacac     1260

ggcctccctg accatctctg ggctccaggc tgaggacgag ggtgactatt actgcaagtc     1320

tctgacaagc acgagacgtc gggttttcgg cactgggacc aagctgaccg ttctaaccgt     1380

ggcggcgccg agcgtgttta tttttccgcc gagcgatgaa cagctgaaaa gcggcaccgc     1440

gagcgtggtg tgcctgctga acaactttta tccgcgcgaa gcgaaagtgc agtggaaagt     1500

ggataacgcg ctgcagagcg gcaacagcca ggaaagcgtg accgaacagg atagcaaaga     1560

tagcacctat agcctgagca gcaccctgac cctgagcaaa gcggattatg aaaaacataa     1620

agtgtatgcg tgcgaagtga cccatcaggg cctgagcagc ccggtgacca aaagctttaa     1680

ccgcggcgaa tgccgcaaac gccgcggcag cggcgcgacc aactttagcc tgctgaaaca     1740

ggcgggcgat gtggaagaaa acccgggccc gatgccacct cctcgcctcc tcttcttcct     1800

cctcttcctc acccccatgg aagtcaggcc cgaggaacct ctagtggtga aggtggaaga     1860

gggagataac gctgtgctgc agtgcctcaa ggggacctca gatggcccca ctcagcagct     1920

gacctggtct cgggagtccc cgcttaaacc cttcttaaaa ctcagcctgg ggctgccagg     1980

cctgggaatc cacatgaggc ccctggccat ctggcttttc atcttcaacg tctctcaaca     2040

gatggggggc ttctacctgt gccagccggg gcccccctct gagaaggcct ggcagcctgg     2100

ctggacagtc aatgtggagg gcagcgggga gctgttccgg tggaatgttt cggacctagg     2160

tggcctgggc tgtggcctga agaacaggtc ctcagagggc cccagctccc cttccgggaa     2220

gctcatgagc cccaagctgt atgtgtgggc caaagaccgc cctgagatct gggagggaga     2280

gcctccgtgt ctcccaccga gggacagcct gaaccagagc ctcagccagg acctcaccat     2340

ggcccctggc tccacactct ggctgtcctg tggggtaccc cctgactctg tgtccagggg     2400

ccccctctcc tggacccatg tgcaccccaa ggggcctaag tcattgctga gcctagagct     2460

gaaggacgat cgcccggcca gagatatgtg ggtaatggag acgggtctgt tgttgccccg     2520

ggccacagct caagacgctg gaaagtatta ttgtcaccgt ggcaacctga ccatgtcatt     2580

ccacctggag atcactgctc ggccagtact atggcactgg ctgctgagga ctggtggctg     2640

gaaggtctca gctgtgactt tggcttatct gatcttctgc ctgtgttccc ttgtgggcat     2700

tcttcatctt caaagagccc tggtcctgag gaggaaaaga aagcgaatga ctgaccccac     2760

caggagattc                                                            2770


<210>  4
<211>  1782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PG9 light chain nucleic acid sequence- encoded region

<400>  4
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcacag       60

tctgccctga ctcagcctgc ctccgtgtct gggtctcctg gacagtcgat caccatctcc      120

tgcaatggaa ccagcaatga tgttggtggc tatgaatctg tctcctggta ccaacaacat      180

cccggcaaag cccccaaagt cgtgatttat gatgtcagta aacggccctc aggggtttct      240

aatcgcttct ctggctccaa gtccggcaac acggcctccc tgaccatctc tgggctccag      300

gctgaggacg agggtgacta ttactgcaag tctctgacaa gcacgagacg tcgggttttc      360

ggcactggga ccaagctgac cgttctaacc gtggcggcgc cgagcgtgtt tatttttccg      420

ccgagcgatg aacagctgaa aagcggcacc gcgagcgtgg tgtgcctgct gaacaacttt      480

tatccgcgcg aagcgaaagt gcagtggaaa gtggataacg cgctgcagag cggcaacagc      540

caggaaagcg tgaccgaaca ggatagcaaa gatagcacct atagcctgag cagcaccctg      600

accctgagca aagcggatta tgaaaaacat aaagtgtatg cgtgcgaagt gacccatcag      660

ggcctgagca gcccggtgac caaaagcttt aaccgcggcg aatgccgcaa acgccgcggc      720

agcggcgcga ccaactttag cctgctgaaa caggcgggcg atgtggaaga aaacccgggc      780

ccgatgccac ctcctcgcct cctcttcttc ctcctcttcc tcacccccat ggaagtcagg      840

cccgaggaac ctctagtggt gaaggtggaa gagggagata acgctgtgct gcagtgcctc      900

aaggggacct cagatggccc cactcagcag ctgacctggt ctcgggagtc cccgcttaaa      960

cccttcttaa aactcagcct ggggctgcca ggcctgggaa tccacatgag gcccctggcc     1020

atctggcttt tcatcttcaa cgtctctcaa cagatggggg gcttctacct gtgccagccg     1080

gggcccccct ctgagaaggc ctggcagcct ggctggacag tcaatgtgga gggcagcggg     1140

gagctgttcc ggtggaatgt ttcggaccta ggtggcctgg gctgtggcct gaagaacagg     1200

tcctcagagg gccccagctc cccttccggg aagctcatga gccccaagct gtatgtgtgg     1260

gccaaagacc gccctgagat ctgggaggga gagcctccgt gtctcccacc gagggacagc     1320

ctgaaccaga gcctcagcca ggacctcacc atggcccctg gctccacact ctggctgtcc     1380

tgtggggtac cccctgactc tgtgtccagg ggccccctct cctggaccca tgtgcacccc     1440

aaggggccta agtcattgct gagcctagag ctgaaggacg atcgcccggc cagagatatg     1500

tgggtaatgg agacgggtct gttgttgccc cgggccacag ctcaagacgc tggaaagtat     1560

tattgtcacc gtggcaacct gaccatgtca ttccacctgg agatcactgc tcggccagta     1620

ctatggcact ggctgctgag gactggtggc tggaaggtct cagctgtgac tttggcttat     1680

ctgatcttct gcctgtgttc ccttgtgggc attcttcatc ttcaaagagc cctggtcctg     1740

aggaggaaaa gaaagcgaat gactgacccc accaggagat tc                        1782


<210>  5
<211>  3661
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PG9 heavy chain nucleic acid sequence

<400>  5
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccatcggct      600

cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt      660

cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt      720

ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc      780

agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttaac ggtggagggc      840

agtgtagtct gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag      900

actaacagac tgttcctttc catgggtctt ttctgcagtc accgtcgtcg acacgtgtga      960

tcagatatcg cggccgctct agaccaccat gggatggtca tgtatcatcc tttttctagt     1020

agcaactgca accggtgtac attcacagcg attagtggag tctgggggag gcgtggtcca     1080

gcctgggtcg tccctgagac tctcctgtgc agcgtccgga ttcgacttca gtagacaagg     1140

catgcactgg gtccgccagg ctccaggcca ggggctggag tgggtggcat ttattaaata     1200

tgatggaagt gagaaatatc atgctgactc cgtatggggc cgactcagca tctccagaga     1260

caattccaag gatacgcttt atctccaaat gaatagcctg agagtcgagg acacggctac     1320

atatttttgt gtgagagagg ctggtgggcc cgactaccgt aatgggtaca actattacga     1380

tttctatgat ggttattata actaccacta tatggacgtc tggggcaaag ggaccacggt     1440

caccgtctcg agcgcgagca ccaaaggccc gagcgtgttt ccgctggcgc cgtgcagccg     1500

cagcaccagc ggcggcaccg cggcgctggg ctgcctggtg aaagattatt ttccggaacc     1560

ggtgaccgtg agctggaaca gcggcgcgct gaccagcggc gtgcatacct ttccggcggt     1620

gctgcagagc agcggcctgt atagcctgag cagcgtggtg accgtgccga gcagcagcct     1680

gggcacccag acctatacct gcaacgtgaa ccataaaccg agcaacacca aagtggataa     1740

acgcgtggaa ctgaaaaccc cgctgggcga taccacccat acctgcccgc gctgcccgga     1800

accgaaaagc tgcgataccc cgccgccgtg cccgcgctgc ccggaaccga aaagctgcga     1860

taccccgccg ccgtgcccgc gctgcccgga accgaaaagc tgcgataccc cgccgccgtg     1920

cccgcgctgc ccggcgccgg aactgctggg cggcccgagc gtgtttctgt ttccgccgaa     1980

accgaaagat accctgatga ttagccgcac cccggaagtg acctgcgtgg tggtggatgt     2040

gagccatgaa gatccggaag tgcagtttaa atggtatgtg gatggcgtgg aagtgcataa     2100

cgcgaaaacc aaaccgcgcg aagaacagta taacagcacc tttcgcgtgg tgagcgtgct     2160

gaccgtgctg catcaggatt ggctgaacgg caaagaatat aaatgcaaag tgagcaacaa     2220

agcgctgccg gcgccgattg aaaaaaccat tagcaaaacc aaaggccagc cgcgcgaacc     2280

gcaggtgtat accctgccgc cgagccgcga agaaatgacc aaaaaccagg tgagcctgac     2340

ctgcctggtg aaaggctttt atccgagcga tattgcggtg gaatgggaaa gcagcggcca     2400

gccggaaaac aactataaca ccaccccgcc gatgctggat agcgatggca gcttttttct     2460

gtatagcaaa ctgaccgtgg ataaaagccg ctggcagcag ggcaacattt ttagctgcag     2520

cgtgatgcat gaagcgctgc ataaccgctt tacccagaaa agcctgagcc tgagcccggg     2580

caaacgcaaa cgccgcggca gcggcgcgac caactttagc ctgctgaaac aggcgggcga     2640

tgtggaagaa aacccgggcc cgatgccacc tcctcgcctc ctcttcttcc tcctcttcct     2700

cacccccatg gaagtcaggc ccgaggaacc tctagtggtg aaggtggaag agggagataa     2760

cgctgtgctg cagtgcctca aggggacctc agatggcccc actcagcagc tgacctggtc     2820

tcgggagtcc ccgcttaaac ccttcttaaa actcagcctg gggctgccag gcctgggaat     2880

ccacatgagg cccctggcca tctggctttt catcttcaac gtctctcaac agatgggggg     2940

cttctacctg tgccagccgg ggcccccctc tgagaaggcc tggcagcctg gctggacagt     3000

caatgtggag ggcagcgggg agctgttccg gtggaatgtt tcggacctag gtggcctggg     3060

ctgtggcctg aagaacaggt cctcagaggg ccccagctcc ccttccggga agctcatgag     3120

ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc tgggagggag agcctccgtg     3180

tctcccaccg agggacagcc tgaaccagag cctcagccag gacctcacca tggcccctgg     3240

ctccacactc tggctgtcct gtggggtacc ccctgactct gtgtccaggg gccccctctc     3300

ctggacccat gtgcacccca aggggcctaa gtcattgctg agcctagagc tgaaggacga     3360

tcgcccggcc agagatatgt gggtaatgga gacgggtctg ttgttgcccc gggccacagc     3420

tcaagacgct ggaaagtatt attgtcaccg tggcaacctg accatgtcat tccacctgga     3480

gatcactgct cggccagtac tatggcactg gctgctgagg actggtggct ggaaggtctc     3540

agctgtgact ttggcttatc tgatcttctg cctgtgttcc cttgtgggca ttcttcatct     3600

tcaaagagcc ctggtcctga ggaggaaaag aaagcgaatg actgacccca ccaggagatt     3660

c                                                                     3661


<210>  6
<211>  2673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PG9 heavy chain nucleic acid sequence-encoded region

<400>  6
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcacag       60

cgattagtgg agtctggggg aggcgtggtc cagcctgggt cgtccctgag actctcctgt      120

gcagcgtccg gattcgactt cagtagacaa ggcatgcact gggtccgcca ggctccaggc      180

caggggctgg agtgggtggc atttattaaa tatgatggaa gtgagaaata tcatgctgac      240

tccgtatggg gccgactcag catctccaga gacaattcca aggatacgct ttatctccaa      300

atgaatagcc tgagagtcga ggacacggct acatattttt gtgtgagaga ggctggtggg      360

cccgactacc gtaatgggta caactattac gatttctatg atggttatta taactaccac      420

tatatggacg tctggggcaa agggaccacg gtcaccgtct cgagcgcgag caccaaaggc      480

ccgagcgtgt ttccgctggc gccgtgcagc cgcagcacca gcggcggcac cgcggcgctg      540

ggctgcctgg tgaaagatta ttttccggaa ccggtgaccg tgagctggaa cagcggcgcg      600

ctgaccagcg gcgtgcatac ctttccggcg gtgctgcaga gcagcggcct gtatagcctg      660

agcagcgtgg tgaccgtgcc gagcagcagc ctgggcaccc agacctatac ctgcaacgtg      720

aaccataaac cgagcaacac caaagtggat aaacgcgtgg aactgaaaac cccgctgggc      780

gataccaccc atacctgccc gcgctgcccg gaaccgaaaa gctgcgatac cccgccgccg      840

tgcccgcgct gcccggaacc gaaaagctgc gataccccgc cgccgtgccc gcgctgcccg      900

gaaccgaaaa gctgcgatac cccgccgccg tgcccgcgct gcccggcgcc ggaactgctg      960

ggcggcccga gcgtgtttct gtttccgccg aaaccgaaag ataccctgat gattagccgc     1020

accccggaag tgacctgcgt ggtggtggat gtgagccatg aagatccgga agtgcagttt     1080

aaatggtatg tggatggcgt ggaagtgcat aacgcgaaaa ccaaaccgcg cgaagaacag     1140

tataacagca cctttcgcgt ggtgagcgtg ctgaccgtgc tgcatcagga ttggctgaac     1200

ggcaaagaat ataaatgcaa agtgagcaac aaagcgctgc cggcgccgat tgaaaaaacc     1260

attagcaaaa ccaaaggcca gccgcgcgaa ccgcaggtgt ataccctgcc gccgagccgc     1320

gaagaaatga ccaaaaacca ggtgagcctg acctgcctgg tgaaaggctt ttatccgagc     1380

gatattgcgg tggaatggga aagcagcggc cagccggaaa acaactataa caccaccccg     1440

ccgatgctgg atagcgatgg cagctttttt ctgtatagca aactgaccgt ggataaaagc     1500

cgctggcagc agggcaacat ttttagctgc agcgtgatgc atgaagcgct gcataaccgc     1560

tttacccaga aaagcctgag cctgagcccg ggcaaacgca aacgccgcgg cagcggcgcg     1620

accaacttta gcctgctgaa acaggcgggc gatgtggaag aaaacccggg cccgatgcca     1680

cctcctcgcc tcctcttctt cctcctcttc ctcaccccca tggaagtcag gcccgaggaa     1740

cctctagtgg tgaaggtgga agagggagat aacgctgtgc tgcagtgcct caaggggacc     1800

tcagatggcc ccactcagca gctgacctgg tctcgggagt ccccgcttaa acccttctta     1860

aaactcagcc tggggctgcc aggcctggga atccacatga ggcccctggc catctggctt     1920

ttcatcttca acgtctctca acagatgggg ggcttctacc tgtgccagcc ggggcccccc     1980

tctgagaagg cctggcagcc tggctggaca gtcaatgtgg agggcagcgg ggagctgttc     2040

cggtggaatg tttcggacct aggtggcctg ggctgtggcc tgaagaacag gtcctcagag     2100

ggccccagct ccccttccgg gaagctcatg agccccaagc tgtatgtgtg ggccaaagac     2160

cgccctgaga tctgggaggg agagcctccg tgtctcccac cgagggacag cctgaaccag     2220

agcctcagcc aggacctcac catggcccct ggctccacac tctggctgtc ctgtggggta     2280

ccccctgact ctgtgtccag gggccccctc tcctggaccc atgtgcaccc caaggggcct     2340

aagtcattgc tgagcctaga gctgaaggac gatcgcccgg ccagagatat gtgggtaatg     2400

gagacgggtc tgttgttgcc ccgggccaca gctcaagacg ctggaaagta ttattgtcac     2460

cgtggcaacc tgaccatgtc attccacctg gagatcactg ctcggccagt actatggcac     2520

tggctgctga ggactggtgg ctggaaggtc tcagctgtga ctttggctta tctgatcttc     2580

tgcctgtgtt cccttgtggg cattcttcat cttcaaagag ccctggtcct gaggaggaaa     2640

agaaagcgaa tgactgaccc caccaggaga ttc                                  2673


<210>  7
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens isolate PG9 anti-HIV immunoglobulin light chain 
       variable region mRNA

<400>  7
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcaatg gaaccagcaa tgatgttggt ggctatgaat ctgtctcctg gtaccaacaa      120

catcccggca aagcccccaa agtcgtgatt tatgatgtca gtaaacggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtccggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgagggtga ctattactgc aagtctctga caagcacgag acgtcgggtt      300

ttcggcactg ggaccaagct gaccgttcta                                       330


<210>  8
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens isolate PG9 anti-HIV immunoglobulin heavy chain 
       variable region mRNA

<400>  8
cagcgattag tggagtctgg gggaggcgtg gtccagcctg ggtcgtccct gagactctcc       60

tgtgcagcgt ccggattcga cttcagtaga caaggcatgc actgggtccg ccaggctcca      120

ggccaggggc tggagtgggt ggcatttatt aaatatgatg gaagtgagaa atatcatgct      180

gactccgtat ggggccgact cagcatctcc agagacaatt ccaaggatac gctttatctc      240

caaatgaata gcctgagagt cgaggacacg gctacatatt tttgtgtgag agaggctggt      300

gggcccgact accgtaatgg gtacaactat tacgatttct atgatggtta ttataactac      360

cactatatgg acgtctgggg caaagggacc acggtcaccg tctcgagc                   408


<210>  9
<211>  3673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PG9 scFv nucleic acid

<400>  9
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccatcggct      600

cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt      660

cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt      720

ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc      780

agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttaac ggtggagggc      840

agtgtagtct gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag      900

actaacagac tgttcctttc catgggtctt ttctgcagtc accgtcgtcg acacgtgtga      960

tcagatatcg cggccgctct agaccaccat ggattggatt tggcgcattc tgtttctggt     1020

gggcgcggcg accggcgcgc atagcgaagt gcagctggtg gaaagcggcg gcggcgtggt     1080

gcgcccgggc ggcagcctgc gcctgagctg cgcggcgagc ggctttacct ttgatgatta     1140

tggcatgagc tgggtgcgcc aggcgccggg caaaggcctg gaatgggtga gcggcattaa     1200

ctggaacggc ggcagcaccg gctatgcgga tagcgtgaaa ggccgcttta ccattagccg     1260

cgataacgcg aaaaacagcc tgtatctgca gatgaacagc ctgcgcgcgg aagataccgc     1320

ggtgtattat tgcgcgcgcg gccgcagcct gctgtttgat tattggggcc agggcaccct     1380

ggtgaccgtg agccgcggcg gcggcggcag cggcggcggc ggcagcggcg gcggcggcag     1440

cggcggcggc ggcagcagca gcgaactgac ccaggatccg gcggtgagcg tggcgctggg     1500

ccagaccgtg cgcattacct gccagggcga tagcctgcgc agctattatg cgagctggta     1560

tcagcagaaa ccgggccagg cgccggtgct ggtgatttat ggcaaaaaca accgcccgag     1620

cggcattccg gatcgcttta gcggcagcag cagcggcaac accgcgagcc tgaccattac     1680

cggcgcgcag gcggaagatg aagcggatta ttattgcaac agccgcgata gcagcggcaa     1740

ccatgtggtg tttggcggcg gcaccaaact gaccgtgggc agcggcggcg gcggcagcca     1800

gcgattagtg gagtctgggg gaggcgtggt ccagcctggg tcgtccctga gactctcctg     1860

tgcagcgtcc ggattcgact tcagtagaca aggcatgcac tgggtccgcc aggctccagg     1920

ccaggggctg gagtgggtgg catttattaa atatgatgga agtgagaaat atcatgctga     1980

ctccgtatgg ggccgactca gcatctccag agacaattcc aaggatacgc tttatctcca     2040

aatgaatagc ctgagagtcg aggacacggc tacatatttt tgtgtgagag aggctggtgg     2100

gcccgactac cgtaatgggt acaactatta cgatttctat gatggttatt ataactacca     2160

ctatatggac gtctggggca aagggaccac ggtcaccgtc tcgagcggcg gcggcggcag     2220

cggcggcggc ggcagcggcg gcggcggcag cggcggcggc ggcagccagt ctgccctgac     2280

tcagcctgcc tccgtgtctg ggtctcctgg acagtcgatc accatctcct gcaatggaac     2340

cagcaatgat gttggtggct atgaatctgt ctcctggtac caacaacatc ccggcaaagc     2400

ccccaaagtc gtgatttatg atgtcagtaa acggccctca ggggtttcta atcgcttctc     2460

tggctccaag tccggcaaca cggcctccct gaccatctct gggctccagg ctgaggacga     2520

gggtgactat tactgcaagt ctctgacaag cacgagacgt cgggttttcg gcactgggac     2580

caagctgacc gttctacgca aacgccgcgg cagcggcgcg accaacttta gcctgctgaa     2640

acaggcgggc gatgtggaag aaaacccggg cccgatgcca cctcctcgcc tcctcttctt     2700

cctcctcttc ctcaccccca tggaagtcag gcccgaggaa cctctagtgg tgaaggtgga     2760

agagggagat aacgctgtgc tgcagtgcct caaggggacc tcagatggcc ccactcagca     2820

gctgacctgg tctcgggagt ccccgcttaa acccttctta aaactcagcc tggggctgcc     2880

aggcctggga atccacatga ggcccctggc catctggctt ttcatcttca acgtctctca     2940

acagatgggg ggcttctacc tgtgccagcc ggggcccccc tctgagaagg cctggcagcc     3000

tggctggaca gtcaatgtgg agggcagcgg ggagctgttc cggtggaatg tttcggacct     3060

aggtggcctg ggctgtggcc tgaagaacag gtcctcagag ggccccagct ccccttccgg     3120

gaagctcatg agccccaagc tgtatgtgtg ggccaaagac cgccctgaga tctgggaggg     3180

agagcctccg tgtctcccac cgagggacag cctgaaccag agcctcagcc aggacctcac     3240

catggcccct ggctccacac tctggctgtc ctgtggggta ccccctgact ctgtgtccag     3300

gggccccctc tcctggaccc atgtgcaccc caaggggcct aagtcattgc tgagcctaga     3360

gctgaaggac gatcgcccgg ccagagatat gtgggtaatg gagacgggtc tgttgttgcc     3420

ccgggccaca gctcaagacg ctggaaagta ttattgtcac cgtggcaacc tgaccatgtc     3480

attccacctg gagatcactg ctcggccagt actatggcac tggctgctga ggactggtgg     3540

ctggaaggtc tcagctgtga ctttggctta tctgatcttc tgcctgtgtt cccttgtggg     3600

cattcttcat cttcaaagag ccctggtcct gaggaggaaa agaaagcgaa tgactgaccc     3660

caccaggaga ttc                                                        3673


<210>  10
<211>  2685
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PG9 scFv nucleic acid- encoded region

<400>  10
atggattgga tttggcgcat tctgtttctg gtgggcgcgg cgaccggcgc gcatagcgaa       60

gtgcagctgg tggaaagcgg cggcggcgtg gtgcgcccgg gcggcagcct gcgcctgagc      120

tgcgcggcga gcggctttac ctttgatgat tatggcatga gctgggtgcg ccaggcgccg      180

ggcaaaggcc tggaatgggt gagcggcatt aactggaacg gcggcagcac cggctatgcg      240

gatagcgtga aaggccgctt taccattagc cgcgataacg cgaaaaacag cctgtatctg      300

cagatgaaca gcctgcgcgc ggaagatacc gcggtgtatt attgcgcgcg cggccgcagc      360

ctgctgtttg attattgggg ccagggcacc ctggtgaccg tgagccgcgg cggcggcggc      420

agcggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcag cagcgaactg      480

acccaggatc cggcggtgag cgtggcgctg ggccagaccg tgcgcattac ctgccagggc      540

gatagcctgc gcagctatta tgcgagctgg tatcagcaga aaccgggcca ggcgccggtg      600

ctggtgattt atggcaaaaa caaccgcccg agcggcattc cggatcgctt tagcggcagc      660

agcagcggca acaccgcgag cctgaccatt accggcgcgc aggcggaaga tgaagcggat      720

tattattgca acagccgcga tagcagcggc aaccatgtgg tgtttggcgg cggcaccaaa      780

ctgaccgtgg gcagcggcgg cggcggcagc cagcgattag tggagtctgg gggaggcgtg      840

gtccagcctg ggtcgtccct gagactctcc tgtgcagcgt ccggattcga cttcagtaga      900

caaggcatgc actgggtccg ccaggctcca ggccaggggc tggagtgggt ggcatttatt      960

aaatatgatg gaagtgagaa atatcatgct gactccgtat ggggccgact cagcatctcc     1020

agagacaatt ccaaggatac gctttatctc caaatgaata gcctgagagt cgaggacacg     1080

gctacatatt tttgtgtgag agaggctggt gggcccgact accgtaatgg gtacaactat     1140

tacgatttct atgatggtta ttataactac cactatatgg acgtctgggg caaagggacc     1200

acggtcaccg tctcgagcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc     1260

agcggcggcg gcggcagcca gtctgccctg actcagcctg cctccgtgtc tgggtctcct     1320

ggacagtcga tcaccatctc ctgcaatgga accagcaatg atgttggtgg ctatgaatct     1380

gtctcctggt accaacaaca tcccggcaaa gcccccaaag tcgtgattta tgatgtcagt     1440

aaacggccct caggggtttc taatcgcttc tctggctcca agtccggcaa cacggcctcc     1500

ctgaccatct ctgggctcca ggctgaggac gagggtgact attactgcaa gtctctgaca     1560

agcacgagac gtcgggtttt cggcactggg accaagctga ccgttctacg caaacgccgc     1620

ggcagcggcg cgaccaactt tagcctgctg aaacaggcgg gcgatgtgga agaaaacccg     1680

ggcccgatgc cacctcctcg cctcctcttc ttcctcctct tcctcacccc catggaagtc     1740

aggcccgagg aacctctagt ggtgaaggtg gaagagggag ataacgctgt gctgcagtgc     1800

ctcaagggga cctcagatgg ccccactcag cagctgacct ggtctcggga gtccccgctt     1860

aaacccttct taaaactcag cctggggctg ccaggcctgg gaatccacat gaggcccctg     1920

gccatctggc ttttcatctt caacgtctct caacagatgg ggggcttcta cctgtgccag     1980

ccggggcccc cctctgagaa ggcctggcag cctggctgga cagtcaatgt ggagggcagc     2040

ggggagctgt tccggtggaa tgtttcggac ctaggtggcc tgggctgtgg cctgaagaac     2100

aggtcctcag agggccccag ctccccttcc gggaagctca tgagccccaa gctgtatgtg     2160

tgggccaaag accgccctga gatctgggag ggagagcctc cgtgtctccc accgagggac     2220

agcctgaacc agagcctcag ccaggacctc accatggccc ctggctccac actctggctg     2280

tcctgtgggg taccccctga ctctgtgtcc aggggccccc tctcctggac ccatgtgcac     2340

cccaaggggc ctaagtcatt gctgagccta gagctgaagg acgatcgccc ggccagagat     2400

atgtgggtaa tggagacggg tctgttgttg ccccgggcca cagctcaaga cgctggaaag     2460

tattattgtc accgtggcaa cctgaccatg tcattccacc tggagatcac tgctcggcca     2520

gtactatggc actggctgct gaggactggt ggctggaagg tctcagctgt gactttggct     2580

tatctgatct tctgcctgtg ttcccttgtg ggcattcttc atcttcaaag agccctggtc     2640

ctgaggagga aaagaaagcg aatgactgac cccaccagga gattc                     2685


<210>  11
<211>  4438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074 full length nucleic acid sequence

<400>  11
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccatcggct      600

cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt      660

cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt      720

ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc      780

agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttaac ggtggagggc      840

agtgtagtct gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag      900

actaacagac tgttcctttc catgggtctt ttctgcagtc accgtcgtcg acacgtgtga      960

tcagatatcg cggccgctct agaccaccat gggatggtca tgtatcatcc tttttctagt     1020

agcaactgca accggtgtac attcatccta tgtcaggcca ctgtccgtcg cactggggga     1080

gaccgcaaga attagctgtg ggaggcaggc actggggagc agggctgtcc agtggtacca     1140

gcaccgacca ggacaggcac caatcctgct gatctacaac aatcaggacc ggccttcagg     1200

catccccgag agattcagcg gaacacccga tattaacttt ggcactagag ctaccctgac     1260

aatcagcgga gtggaggcag gcgacgaagc cgattactat tgccatatgt gggactccag     1320

gtctgggttc agttggtcat ttggcggagc aactcgactg accgtgctga ccgtggcggc     1380

gccgagcgtg tttatttttc cgccgagcga tgaacagctg aaaagcggca ccgcgagcgt     1440

ggtgtgcctg ctgaacaact tttatccgcg cgaagcgaaa gtgcagtgga aagtggataa     1500

cgcgctgcag agcggcaaca gccaggaaag cgtgaccgaa caggatagca aagatagcac     1560

ctatagcctg agcagcaccc tgaccctgag caaagcggat tatgaaaaac ataaagtgta     1620

tgcgtgcgaa gtgacccatc agggcctgag cagcccggtg accaaaagct ttaaccgcgg     1680

cgaatgccgc aaacgccgcg gcagcggcgc gaccaacttt agcctgctga aacaggcggg     1740

cgatgtggaa gaaaacccgg gcccgatggg atggtcatgt atcatccttt ttctagtagc     1800

aactgcaacc ggtgtacatt cacaggtgca gctgcaggaa tctgggcctg gactggtcaa     1860

accctccgag actctgagcg tcacttgttc tgtgagcggc gactctatga acaattacta     1920

ttggacatgg atccgacaga gcccaggcaa ggggctggag tggatcggct acatttctga     1980

cagagaaagt gctacttata accctagcct gaattccagg gtggtcattt cacgcgacac     2040

cagcaagaac cagctgtccc tgaaactgaa ttctgtgacc cccgcagata cagccgtcta     2100

ctattgcgcc accgctcgga gaggacagcg gatctacggc gtggtcagct tcggggagtt     2160

cttttactac tactcaatgg atgtctgggg gaaggggact acagtgaccg tctcaagcgc     2220

ctcgaccaag gcgagcacca aaggcccgag cgtgtttccg ctggcgccgt gcagccgcag     2280

caccagcggc ggcaccgcgg cgctgggctg cctggtgaaa gattattttc cggaaccggt     2340

gaccgtgagc tggaacagcg gcgcgctgac cagcggcgtg catacctttc cggcggtgct     2400

gcagagcagc ggcctgtata gcctgagcag cgtggtgacc gtgccgagca gcagcctggg     2460

cacccagacc tatacctgca acgtgaacca taaaccgagc aacaccaaag tggataaacg     2520

cgtggaactg aaaaccccgc tgggcgatac cacccatacc tgcccgcgct gcccggaacc     2580

gaaaagctgc gataccccgc cgccgtgccc gcgctgcccg gaaccgaaaa gctgcgatac     2640

cccgccgccg tgcccgcgct gcccggaacc gaaaagctgc gataccccgc cgccgtgccc     2700

gcgctgcccg gcgccggaac tgctgggcgg cccgagcgtg tttctgtttc cgccgaaacc     2760

gaaagatacc ctgatgatta gccgcacccc ggaagtgacc tgcgtggtgg tggatgtgag     2820

ccatgaagat ccggaagtgc agtttaaatg gtatgtggat ggcgtggaag tgcataacgc     2880

gaaaaccaaa ccgcgcgaag aacagtataa cagcaccttt cgcgtggtga gcgtgctgac     2940

cgtgctgcat caggattggc tgaacggcaa agaatataaa tgcaaagtga gcaacaaagc     3000

gctgccggcg ccgattgaaa aaaccattag caaaaccaaa ggccagccgc gcgaaccgca     3060

ggtgtatacc ctgccgccga gccgcgaaga aatgaccaaa aaccaggtga gcctgacctg     3120

cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa tgggaaagca gcggccagcc     3180

ggaaaacaac tataacacca ccccgccgat gctggatagc gatggcagct tttttctgta     3240

tagcaaactg accgtggata aaagccgctg gcagcagggc aacattttta gctgcagcgt     3300

gatgcatgaa gcgctgcata accgctttac ccagaaaagc ctgagcctga gcccgggcaa     3360

acgcaaacgc cgcggcagcg gcgcgaccaa ctttagcctg ctgaaacagg cgggcgatgt     3420

ggaagaaaac ccgggcccga tgccacctcc tcgcctcctc ttcttcctcc tcttcctcac     3480

ccccatggaa gtcaggcccg aggaacctct agtggtgaag gtggaagagg gagataacgc     3540

tgtgctgcag tgcctcaagg ggacctcaga tggccccact cagcagctga cctggtctcg     3600

ggagtccccg cttaaaccct tcttaaaact cagcctgggg ctgccaggcc tgggaatcca     3660

catgaggccc ctggccatct ggcttttcat cttcaacgtc tctcaacaga tggggggctt     3720

ctacctgtgc cagccggggc ccccctctga gaaggcctgg cagcctggct ggacagtcaa     3780

tgtggagggc agcggggagc tgttccggtg gaatgtttcg gacctaggtg gcctgggctg     3840

tggcctgaag aacaggtcct cagagggccc cagctcccct tccgggaagc tcatgagccc     3900

caagctgtat gtgtgggcca aagaccgccc tgagatctgg gagggagagc ctccgtgtct     3960

cccaccgagg gacagcctga accagagcct cagccaggac ctcaccatgg cccctggctc     4020

cacactctgg ctgtcctgtg gggtaccccc tgactctgtg tccaggggcc ccctctcctg     4080

gacccatgtg caccccaagg ggcctaagtc attgctgagc ctagagctga aggacgatcg     4140

cccggccaga gatatgtggg taatggagac gggtctgttg ttgccccggg ccacagctca     4200

agacgctgga aagtattatt gtcaccgtgg caacctgacc atgtcattcc acctggagat     4260

cactgctcgg ccagtactat ggcactggct gctgaggact ggtggctgga aggtctcagc     4320

tgtgactttg gcttatctga tcttctgcct gtgttccctt gtgggcattc ttcatcttca     4380

aagagccctg gtcctgagga ggaaaagaaa gcgaatgact gaccccacca ggagattc       4438


<210>  12
<211>  3450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074 full length nucleic acid sequence- encoded region

<400>  12
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcatcc       60

tatgtcaggc cactgtccgt cgcactgggg gagaccgcaa gaattagctg tgggaggcag      120

gcactgggga gcagggctgt ccagtggtac cagcaccgac caggacaggc accaatcctg      180

ctgatctaca acaatcagga ccggccttca ggcatccccg agagattcag cggaacaccc      240

gatattaact ttggcactag agctaccctg acaatcagcg gagtggaggc aggcgacgaa      300

gccgattact attgccatat gtgggactcc aggtctgggt tcagttggtc atttggcgga      360

gcaactcgac tgaccgtgct gaccgtggcg gcgccgagcg tgtttatttt tccgccgagc      420

gatgaacagc tgaaaagcgg caccgcgagc gtggtgtgcc tgctgaacaa cttttatccg      480

cgcgaagcga aagtgcagtg gaaagtggat aacgcgctgc agagcggcaa cagccaggaa      540

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccctg      600

agcaaagcgg attatgaaaa acataaagtg tatgcgtgcg aagtgaccca tcagggcctg      660

agcagcccgg tgaccaaaag ctttaaccgc ggcgaatgcc gcaaacgccg cggcagcggc      720

gcgaccaact ttagcctgct gaaacaggcg ggcgatgtgg aagaaaaccc gggcccgatg      780

ggatggtcat gtatcatcct ttttctagta gcaactgcaa ccggtgtaca ttcacaggtg      840

cagctgcagg aatctgggcc tggactggtc aaaccctccg agactctgag cgtcacttgt      900

tctgtgagcg gcgactctat gaacaattac tattggacat ggatccgaca gagcccaggc      960

aaggggctgg agtggatcgg ctacatttct gacagagaaa gtgctactta taaccctagc     1020

ctgaattcca gggtggtcat ttcacgcgac accagcaaga accagctgtc cctgaaactg     1080

aattctgtga cccccgcaga tacagccgtc tactattgcg ccaccgctcg gagaggacag     1140

cggatctacg gcgtggtcag cttcggggag ttcttttact actactcaat ggatgtctgg     1200

gggaagggga ctacagtgac cgtctcaagc gcctcgacca aggcgagcac caaaggcccg     1260

agcgtgtttc cgctggcgcc gtgcagccgc agcaccagcg gcggcaccgc ggcgctgggc     1320

tgcctggtga aagattattt tccggaaccg gtgaccgtga gctggaacag cggcgcgctg     1380

accagcggcg tgcatacctt tccggcggtg ctgcagagca gcggcctgta tagcctgagc     1440

agcgtggtga ccgtgccgag cagcagcctg ggcacccaga cctatacctg caacgtgaac     1500

cataaaccga gcaacaccaa agtggataaa cgcgtggaac tgaaaacccc gctgggcgat     1560

accacccata cctgcccgcg ctgcccggaa ccgaaaagct gcgatacccc gccgccgtgc     1620

ccgcgctgcc cggaaccgaa aagctgcgat accccgccgc cgtgcccgcg ctgcccggaa     1680

ccgaaaagct gcgatacccc gccgccgtgc ccgcgctgcc cggcgccgga actgctgggc     1740

ggcccgagcg tgtttctgtt tccgccgaaa ccgaaagata ccctgatgat tagccgcacc     1800

ccggaagtga cctgcgtggt ggtggatgtg agccatgaag atccggaagt gcagtttaaa     1860

tggtatgtgg atggcgtgga agtgcataac gcgaaaacca aaccgcgcga agaacagtat     1920

aacagcacct ttcgcgtggt gagcgtgctg accgtgctgc atcaggattg gctgaacggc     1980

aaagaatata aatgcaaagt gagcaacaaa gcgctgccgg cgccgattga aaaaaccatt     2040

agcaaaacca aaggccagcc gcgcgaaccg caggtgtata ccctgccgcc gagccgcgaa     2100

gaaatgacca aaaaccaggt gagcctgacc tgcctggtga aaggctttta tccgagcgat     2160

attgcggtgg aatgggaaag cagcggccag ccggaaaaca actataacac caccccgccg     2220

atgctggata gcgatggcag cttttttctg tatagcaaac tgaccgtgga taaaagccgc     2280

tggcagcagg gcaacatttt tagctgcagc gtgatgcatg aagcgctgca taaccgcttt     2340

acccagaaaa gcctgagcct gagcccgggc aaacgcaaac gccgcggcag cggcgcgacc     2400

aactttagcc tgctgaaaca ggcgggcgat gtggaagaaa acccgggccc gatgccacct     2460

cctcgcctcc tcttcttcct cctcttcctc acccccatgg aagtcaggcc cgaggaacct     2520

ctagtggtga aggtggaaga gggagataac gctgtgctgc agtgcctcaa ggggacctca     2580

gatggcccca ctcagcagct gacctggtct cgggagtccc cgcttaaacc cttcttaaaa     2640

ctcagcctgg ggctgccagg cctgggaatc cacatgaggc ccctggccat ctggcttttc     2700

atcttcaacg tctctcaaca gatggggggc ttctacctgt gccagccggg gcccccctct     2760

gagaaggcct ggcagcctgg ctggacagtc aatgtggagg gcagcgggga gctgttccgg     2820

tggaatgttt cggacctagg tggcctgggc tgtggcctga agaacaggtc ctcagagggc     2880

cccagctccc cttccgggaa gctcatgagc cccaagctgt atgtgtgggc caaagaccgc     2940

cctgagatct gggagggaga gcctccgtgt ctcccaccga gggacagcct gaaccagagc     3000

ctcagccagg acctcaccat ggcccctggc tccacactct ggctgtcctg tggggtaccc     3060

cctgactctg tgtccagggg ccccctctcc tggacccatg tgcaccccaa ggggcctaag     3120

tcattgctga gcctagagct gaaggacgat cgcccggcca gagatatgtg ggtaatggag     3180

acgggtctgt tgttgccccg ggccacagct caagacgctg gaaagtatta ttgtcaccgt     3240

ggcaacctga ccatgtcatt ccacctggag atcactgctc ggccagtact atggcactgg     3300

ctgctgagga ctggtggctg gaaggtctca gctgtgactt tggcttatct gatcttctgc     3360

ctgtgttccc ttgtgggcat tcttcatctt caaagagccc tggtcctgag gaggaaaaga     3420

aagcgaatga ctgaccccac caggagattc                                      3450


<210>  13
<211>  2764
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074 light chain nucleic acid sequence

<400>  13
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccatcggct      600

cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt      660

cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt      720

ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc      780

agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttaac ggtggagggc      840

agtgtagtct gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag      900

actaacagac tgttcctttc catgggtctt ttctgcagtc accgtcgtcg acacgtgtga      960

tcagatatcg cggccgctct agaccaccat gggatggtca tgtatcatcc tttttctagt     1020

agcaactgca accggtgtac attcatccta tgtcaggcca ctgtccgtcg cactggggga     1080

gaccgcaaga attagctgtg ggaggcaggc actggggagc agggctgtcc agtggtacca     1140

gcaccgacca ggacaggcac caatcctgct gatctacaac aatcaggacc ggccttcagg     1200

catccccgag agattcagcg gaacacccga tattaacttt ggcactagag ctaccctgac     1260

aatcagcgga gtggaggcag gcgacgaagc cgattactat tgccatatgt gggactccag     1320

gtctgggttc agttggtcat ttggcggagc aactcgactg accgtgctga ccgtggcggc     1380

gccgagcgtg tttatttttc cgccgagcga tgaacagctg aaaagcggca ccgcgagcgt     1440

ggtgtgcctg ctgaacaact tttatccgcg cgaagcgaaa gtgcagtgga aagtggataa     1500

cgcgctgcag agcggcaaca gccaggaaag cgtgaccgaa caggatagca aagatagcac     1560

ctatagcctg agcagcaccc tgaccctgag caaagcggat tatgaaaaac ataaagtgta     1620

tgcgtgcgaa gtgacccatc agggcctgag cagcccggtg accaaaagct ttaaccgcgg     1680

cgaatgccgc aaacgccgcg gcagcggcgc gaccaacttt agcctgctga aacaggcggg     1740

cgatgtggaa gaaaacccgg gcccgatgcc acctcctcgc ctcctcttct tcctcctctt     1800

cctcaccccc atggaagtca ggcccgagga acctctagtg gtgaaggtgg aagagggaga     1860

taacgctgtg ctgcagtgcc tcaaggggac ctcagatggc cccactcagc agctgacctg     1920

gtctcgggag tccccgctta aacccttctt aaaactcagc ctggggctgc caggcctggg     1980

aatccacatg aggcccctgg ccatctggct tttcatcttc aacgtctctc aacagatggg     2040

gggcttctac ctgtgccagc cggggccccc ctctgagaag gcctggcagc ctggctggac     2100

agtcaatgtg gagggcagcg gggagctgtt ccggtggaat gtttcggacc taggtggcct     2160

gggctgtggc ctgaagaaca ggtcctcaga gggccccagc tccccttccg ggaagctcat     2220

gagccccaag ctgtatgtgt gggccaaaga ccgccctgag atctgggagg gagagcctcc     2280

gtgtctccca ccgagggaca gcctgaacca gagcctcagc caggacctca ccatggcccc     2340

tggctccaca ctctggctgt cctgtggggt accccctgac tctgtgtcca ggggccccct     2400

ctcctggacc catgtgcacc ccaaggggcc taagtcattg ctgagcctag agctgaagga     2460

cgatcgcccg gccagagata tgtgggtaat ggagacgggt ctgttgttgc cccgggccac     2520

agctcaagac gctggaaagt attattgtca ccgtggcaac ctgaccatgt cattccacct     2580

ggagatcact gctcggccag tactatggca ctggctgctg aggactggtg gctggaaggt     2640

ctcagctgtg actttggctt atctgatctt ctgcctgtgt tcccttgtgg gcattcttca     2700

tcttcaaaga gccctggtcc tgaggaggaa aagaaagcga atgactgacc ccaccaggag     2760

attc                                                                  2764


<210>  14
<211>  1776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074 light chain nucleic acid sequence- encoded region

<400>  14
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcatcc       60

tatgtcaggc cactgtccgt cgcactgggg gagaccgcaa gaattagctg tgggaggcag      120

gcactgggga gcagggctgt ccagtggtac cagcaccgac caggacaggc accaatcctg      180

ctgatctaca acaatcagga ccggccttca ggcatccccg agagattcag cggaacaccc      240

gatattaact ttggcactag agctaccctg acaatcagcg gagtggaggc aggcgacgaa      300

gccgattact attgccatat gtgggactcc aggtctgggt tcagttggtc atttggcgga      360

gcaactcgac tgaccgtgct gaccgtggcg gcgccgagcg tgtttatttt tccgccgagc      420

gatgaacagc tgaaaagcgg caccgcgagc gtggtgtgcc tgctgaacaa cttttatccg      480

cgcgaagcga aagtgcagtg gaaagtggat aacgcgctgc agagcggcaa cagccaggaa      540

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccctg      600

agcaaagcgg attatgaaaa acataaagtg tatgcgtgcg aagtgaccca tcagggcctg      660

agcagcccgg tgaccaaaag ctttaaccgc ggcgaatgcc gcaaacgccg cggcagcggc      720

gcgaccaact ttagcctgct gaaacaggcg ggcgatgtgg aagaaaaccc gggcccgatg      780

ccacctcctc gcctcctctt cttcctcctc ttcctcaccc ccatggaagt caggcccgag      840

gaacctctag tggtgaaggt ggaagaggga gataacgctg tgctgcagtg cctcaagggg      900

acctcagatg gccccactca gcagctgacc tggtctcggg agtccccgct taaacccttc      960

ttaaaactca gcctggggct gccaggcctg ggaatccaca tgaggcccct ggccatctgg     1020

cttttcatct tcaacgtctc tcaacagatg gggggcttct acctgtgcca gccggggccc     1080

ccctctgaga aggcctggca gcctggctgg acagtcaatg tggagggcag cggggagctg     1140

ttccggtgga atgtttcgga cctaggtggc ctgggctgtg gcctgaagaa caggtcctca     1200

gagggcccca gctccccttc cgggaagctc atgagcccca agctgtatgt gtgggccaaa     1260

gaccgccctg agatctggga gggagagcct ccgtgtctcc caccgaggga cagcctgaac     1320

cagagcctca gccaggacct caccatggcc cctggctcca cactctggct gtcctgtggg     1380

gtaccccctg actctgtgtc caggggcccc ctctcctgga cccatgtgca ccccaagggg     1440

cctaagtcat tgctgagcct agagctgaag gacgatcgcc cggccagaga tatgtgggta     1500

atggagacgg gtctgttgtt gccccgggcc acagctcaag acgctggaaa gtattattgt     1560

caccgtggca acctgaccat gtcattccac ctggagatca ctgctcggcc agtactatgg     1620

cactggctgc tgaggactgg tggctggaag gtctcagctg tgactttggc ttatctgatc     1680

ttctgcctgt gttcccttgt gggcattctt catcttcaaa gagccctggt cctgaggagg     1740

aaaagaaagc gaatgactga ccccaccagg agattc                               1776


<210>  15
<211>  3661
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074 heavy chain nucleic acid sequence

<400>  15
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccatcggct      600

cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt      660

cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt      720

ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc      780

agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttaac ggtggagggc      840

agtgtagtct gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag      900

actaacagac tgttcctttc catgggtctt ttctgcagtc accgtcgtcg acacgtgtga      960

tcagatatcg cggccgctct agaccaccat gggatggtca tgtatcatcc tttttctagt     1020

agcaactgca accggtgtac attcacaggt gcagctgcag gaatctgggc ctggactggt     1080

caaaccctcc gagactctga gcgtcacttg ttctgtgagc ggcgactcta tgaacaatta     1140

ctattggaca tggatccgac agagcccagg caaggggctg gagtggatcg gctacatttc     1200

tgacagagaa agtgctactt ataaccctag cctgaattcc agggtggtca tttcacgcga     1260

caccagcaag aaccagctgt ccctgaaact gaattctgtg acccccgcag atacagccgt     1320

ctactattgc gccaccgctc ggagaggaca gcggatctac ggcgtggtca gcttcgggga     1380

gttcttttac tactactcaa tggatgtctg ggggaagggg actacagtga ccgtctcaag     1440

cgcctcgacc aaggcgagca ccaaaggccc gagcgtgttt ccgctggcgc cgtgcagccg     1500

cagcaccagc ggcggcaccg cggcgctggg ctgcctggtg aaagattatt ttccggaacc     1560

ggtgaccgtg agctggaaca gcggcgcgct gaccagcggc gtgcatacct ttccggcggt     1620

gctgcagagc agcggcctgt atagcctgag cagcgtggtg accgtgccga gcagcagcct     1680

gggcacccag acctatacct gcaacgtgaa ccataaaccg agcaacacca aagtggataa     1740

acgcgtggaa ctgaaaaccc cgctgggcga taccacccat acctgcccgc gctgcccgga     1800

accgaaaagc tgcgataccc cgccgccgtg cccgcgctgc ccggaaccga aaagctgcga     1860

taccccgccg ccgtgcccgc gctgcccgga accgaaaagc tgcgataccc cgccgccgtg     1920

cccgcgctgc ccggcgccgg aactgctggg cggcccgagc gtgtttctgt ttccgccgaa     1980

accgaaagat accctgatga ttagccgcac cccggaagtg acctgcgtgg tggtggatgt     2040

gagccatgaa gatccggaag tgcagtttaa atggtatgtg gatggcgtgg aagtgcataa     2100

cgcgaaaacc aaaccgcgcg aagaacagta taacagcacc tttcgcgtgg tgagcgtgct     2160

gaccgtgctg catcaggatt ggctgaacgg caaagaatat aaatgcaaag tgagcaacaa     2220

agcgctgccg gcgccgattg aaaaaaccat tagcaaaacc aaaggccagc cgcgcgaacc     2280

gcaggtgtat accctgccgc cgagccgcga agaaatgacc aaaaaccagg tgagcctgac     2340

ctgcctggtg aaaggctttt atccgagcga tattgcggtg gaatgggaaa gcagcggcca     2400

gccggaaaac aactataaca ccaccccgcc gatgctggat agcgatggca gcttttttct     2460

gtatagcaaa ctgaccgtgg ataaaagccg ctggcagcag ggcaacattt ttagctgcag     2520

cgtgatgcat gaagcgctgc ataaccgctt tacccagaaa agcctgagcc tgagcccggg     2580

caaacgcaaa cgccgcggca gcggcgcgac caactttagc ctgctgaaac aggcgggcga     2640

tgtggaagaa aacccgggcc cgatgccacc tcctcgcctc ctcttcttcc tcctcttcct     2700

cacccccatg gaagtcaggc ccgaggaacc tctagtggtg aaggtggaag agggagataa     2760

cgctgtgctg cagtgcctca aggggacctc agatggcccc actcagcagc tgacctggtc     2820

tcgggagtcc ccgcttaaac ccttcttaaa actcagcctg gggctgccag gcctgggaat     2880

ccacatgagg cccctggcca tctggctttt catcttcaac gtctctcaac agatgggggg     2940

cttctacctg tgccagccgg ggcccccctc tgagaaggcc tggcagcctg gctggacagt     3000

caatgtggag ggcagcgggg agctgttccg gtggaatgtt tcggacctag gtggcctggg     3060

ctgtggcctg aagaacaggt cctcagaggg ccccagctcc ccttccggga agctcatgag     3120

ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc tgggagggag agcctccgtg     3180

tctcccaccg agggacagcc tgaaccagag cctcagccag gacctcacca tggcccctgg     3240

ctccacactc tggctgtcct gtggggtacc ccctgactct gtgtccaggg gccccctctc     3300

ctggacccat gtgcacccca aggggcctaa gtcattgctg agcctagagc tgaaggacga     3360

tcgcccggcc agagatatgt gggtaatgga gacgggtctg ttgttgcccc gggccacagc     3420

tcaagacgct ggaaagtatt attgtcaccg tggcaacctg accatgtcat tccacctgga     3480

gatcactgct cggccagtac tatggcactg gctgctgagg actggtggct ggaaggtctc     3540

agctgtgact ttggcttatc tgatcttctg cctgtgttcc cttgtgggca ttcttcatct     3600

tcaaagagcc ctggtcctga ggaggaaaag aaagcgaatg actgacccca ccaggagatt     3660

c                                                                     3661


<210>  16
<211>  2673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074 heavy chain nucleic acid sequence- encoded region

<400>  16
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcacag       60

gtgcagctgc aggaatctgg gcctggactg gtcaaaccct ccgagactct gagcgtcact      120

tgttctgtga gcggcgactc tatgaacaat tactattgga catggatccg acagagccca      180

ggcaaggggc tggagtggat cggctacatt tctgacagag aaagtgctac ttataaccct      240

agcctgaatt ccagggtggt catttcacgc gacaccagca agaaccagct gtccctgaaa      300

ctgaattctg tgacccccgc agatacagcc gtctactatt gcgccaccgc tcggagagga      360

cagcggatct acggcgtggt cagcttcggg gagttctttt actactactc aatggatgtc      420

tgggggaagg ggactacagt gaccgtctca agcgcctcga ccaaggcgag caccaaaggc      480

ccgagcgtgt ttccgctggc gccgtgcagc cgcagcacca gcggcggcac cgcggcgctg      540

ggctgcctgg tgaaagatta ttttccggaa ccggtgaccg tgagctggaa cagcggcgcg      600

ctgaccagcg gcgtgcatac ctttccggcg gtgctgcaga gcagcggcct gtatagcctg      660

agcagcgtgg tgaccgtgcc gagcagcagc ctgggcaccc agacctatac ctgcaacgtg      720

aaccataaac cgagcaacac caaagtggat aaacgcgtgg aactgaaaac cccgctgggc      780

gataccaccc atacctgccc gcgctgcccg gaaccgaaaa gctgcgatac cccgccgccg      840

tgcccgcgct gcccggaacc gaaaagctgc gataccccgc cgccgtgccc gcgctgcccg      900

gaaccgaaaa gctgcgatac cccgccgccg tgcccgcgct gcccggcgcc ggaactgctg      960

ggcggcccga gcgtgtttct gtttccgccg aaaccgaaag ataccctgat gattagccgc     1020

accccggaag tgacctgcgt ggtggtggat gtgagccatg aagatccgga agtgcagttt     1080

aaatggtatg tggatggcgt ggaagtgcat aacgcgaaaa ccaaaccgcg cgaagaacag     1140

tataacagca cctttcgcgt ggtgagcgtg ctgaccgtgc tgcatcagga ttggctgaac     1200

ggcaaagaat ataaatgcaa agtgagcaac aaagcgctgc cggcgccgat tgaaaaaacc     1260

attagcaaaa ccaaaggcca gccgcgcgaa ccgcaggtgt ataccctgcc gccgagccgc     1320

gaagaaatga ccaaaaacca ggtgagcctg acctgcctgg tgaaaggctt ttatccgagc     1380

gatattgcgg tggaatggga aagcagcggc cagccggaaa acaactataa caccaccccg     1440

ccgatgctgg atagcgatgg cagctttttt ctgtatagca aactgaccgt ggataaaagc     1500

cgctggcagc agggcaacat ttttagctgc agcgtgatgc atgaagcgct gcataaccgc     1560

tttacccaga aaagcctgag cctgagcccg ggcaaacgca aacgccgcgg cagcggcgcg     1620

accaacttta gcctgctgaa acaggcgggc gatgtggaag aaaacccggg cccgatgcca     1680

cctcctcgcc tcctcttctt cctcctcttc ctcaccccca tggaagtcag gcccgaggaa     1740

cctctagtgg tgaaggtgga agagggagat aacgctgtgc tgcagtgcct caaggggacc     1800

tcagatggcc ccactcagca gctgacctgg tctcgggagt ccccgcttaa acccttctta     1860

aaactcagcc tggggctgcc aggcctggga atccacatga ggcccctggc catctggctt     1920

ttcatcttca acgtctctca acagatgggg ggcttctacc tgtgccagcc ggggcccccc     1980

tctgagaagg cctggcagcc tggctggaca gtcaatgtgg agggcagcgg ggagctgttc     2040

cggtggaatg tttcggacct aggtggcctg ggctgtggcc tgaagaacag gtcctcagag     2100

ggccccagct ccccttccgg gaagctcatg agccccaagc tgtatgtgtg ggccaaagac     2160

cgccctgaga tctgggaggg agagcctccg tgtctcccac cgagggacag cctgaaccag     2220

agcctcagcc aggacctcac catggcccct ggctccacac tctggctgtc ctgtggggta     2280

ccccctgact ctgtgtccag gggccccctc tcctggaccc atgtgcaccc caaggggcct     2340

aagtcattgc tgagcctaga gctgaaggac gatcgcccgg ccagagatat gtgggtaatg     2400

gagacgggtc tgttgttgcc ccgggccaca gctcaagacg ctggaaagta ttattgtcac     2460

cgtggcaacc tgaccatgtc attccacctg gagatcactg ctcggccagt actatggcac     2520

tggctgctga ggactggtgg ctggaaggtc tcagctgtga ctttggctta tctgatcttc     2580

tgcctgtgtt cccttgtggg cattcttcat cttcaaagag ccctggtcct gaggaggaaa     2640

agaaagcgaa tgactgaccc caccaggaga ttc                                  2673


<210>  17
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074-LC_1012F- light chain variable region

<400>  17
tcctatgtca ggccactgtc cgtcgcactg ggggagaccg caagaattag ctgtgggagg       60

caggcactgg ggagcagggc tgtccagtgg taccagcacc gaccaggaca ggcaccaatc      120

ctgctgatct acaacaatca ggaccggcct tcaggcatcc ccgagagatt cagcggaaca      180

cccgatatta actttggcac tagagctacc ctgacaatca gcggagtgga ggcaggcgac      240

gaagccgatt actattgcca tatgtgggac tccaggtctg ggttcagttg gtcatttggc      300

ggagcaactc gactgaccgt gctg                                             324


<210>  18
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074-LC_1012F- heavy chain variable region

<400>  18
caggtgcagc tgcaggaatc tgggcctgga ctggtcaaac cctccgagac tctgagcgtc       60

acttgttctg tgagcggcga ctctatgaac aattactatt ggacatggat ccgacagagc      120

ccaggcaagg ggctggagtg gatcggctac atttctgaca gagaaagtgc tacttataac      180

cctagcctga attccagggt ggtcatttca cgcgacacca gcaagaacca gctgtccctg      240

aaactgaatt ctgtgacccc cgcagataca gccgtctact attgcgccac cgctcggaga      300

ggacagcgga tctacggcgt ggtcagcttc ggggagttct tttactacta ctcaatggat      360

gtctggggga aggggactac agtgaccgtc tcaagcgcct cgaccaag                   408


<210>  19
<211>  3667
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074 scFv nucleic acid sequence

<400>  19
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccatcggct      600

cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt      660

cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt      720

ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc      780

agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttaac ggtggagggc      840

agtgtagtct gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag      900

actaacagac tgttcctttc catgggtctt ttctgcagtc accgtcgtcg acacgtgtga      960

tcagatatcg cggccgctct agaccaccat ggattggatt tggcgcattc tgtttctggt     1020

gggcgcggcg accggcgcgc atagcgaagt gcagctggtg gaaagcggcg gcggcgtggt     1080

gcgcccgggc ggcagcctgc gcctgagctg cgcggcgagc ggctttacct ttgatgatta     1140

tggcatgagc tgggtgcgcc aggcgccggg caaaggcctg gaatgggtga gcggcattaa     1200

ctggaacggc ggcagcaccg gctatgcgga tagcgtgaaa ggccgcttta ccattagccg     1260

cgataacgcg aaaaacagcc tgtatctgca gatgaacagc ctgcgcgcgg aagataccgc     1320

ggtgtattat tgcgcgcgcg gccgcagcct gctgtttgat tattggggcc agggcaccct     1380

ggtgaccgtg agccgcggcg gcggcggcag cggcggcggc ggcagcggcg gcggcggcag     1440

cggcggcggc ggcagcagca gcgaactgac ccaggatccg gcggtgagcg tggcgctggg     1500

ccagaccgtg cgcattacct gccagggcga tagcctgcgc agctattatg cgagctggta     1560

tcagcagaaa ccgggccagg cgccggtgct ggtgatttat ggcaaaaaca accgcccgag     1620

cggcattccg gatcgcttta gcggcagcag cagcggcaac accgcgagcc tgaccattac     1680

cggcgcgcag gcggaagatg aagcggatta ttattgcaac agccgcgata gcagcggcaa     1740

ccatgtggtg tttggcggcg gcaccaaact gaccgtgggc agcggcggcg gcggcagcca     1800

ggtgcagctg caggaatctg ggcctggact ggtcaaaccc tccgagactc tgagcgtcac     1860

ttgttctgtg agcggcgact ctatgaacaa ttactattgg acatggatcc gacagagccc     1920

aggcaagggg ctggagtgga tcggctacat ttctgacaga gaaagtgcta cttataaccc     1980

tagcctgaat tccagggtgg tcatttcacg cgacaccagc aagaaccagc tgtccctgaa     2040

actgaattct gtgacccccg cagatacagc cgtctactat tgcgccaccg ctcggagagg     2100

acagcggatc tacggcgtgg tcagcttcgg ggagttcttt tactactact caatggatgt     2160

ctgggggaag gggactacag tgaccgtctc aagcgcctcg accaagggcg gcggcggcag     2220

cggcggcggc ggcagcggcg gcggcggcag cggcggcggc ggcagctcct atgtcaggcc     2280

actgtccgtc gcactggggg agaccgcaag aattagctgt gggaggcagg cactggggag     2340

cagggctgtc cagtggtacc agcaccgacc aggacaggca ccaatcctgc tgatctacaa     2400

caatcaggac cggccttcag gcatccccga gagattcagc ggaacacccg atattaactt     2460

tggcactaga gctaccctga caatcagcgg agtggaggca ggcgacgaag ccgattacta     2520

ttgccatatg tgggactcca ggtctgggtt cagttggtca tttggcggag caactcgact     2580

gaccgtgctg cgcaaacgcc gcggcagcgg cgcgaccaac tttagcctgc tgaaacaggc     2640

gggcgatgtg gaagaaaacc cgggcccgat gccacctcct cgcctcctct tcttcctcct     2700

cttcctcacc cccatggaag tcaggcccga ggaacctcta gtggtgaagg tggaagaggg     2760

agataacgct gtgctgcagt gcctcaaggg gacctcagat ggccccactc agcagctgac     2820

ctggtctcgg gagtccccgc ttaaaccctt cttaaaactc agcctggggc tgccaggcct     2880

gggaatccac atgaggcccc tggccatctg gcttttcatc ttcaacgtct ctcaacagat     2940

ggggggcttc tacctgtgcc agccggggcc cccctctgag aaggcctggc agcctggctg     3000

gacagtcaat gtggagggca gcggggagct gttccggtgg aatgtttcgg acctaggtgg     3060

cctgggctgt ggcctgaaga acaggtcctc agagggcccc agctcccctt ccgggaagct     3120

catgagcccc aagctgtatg tgtgggccaa agaccgccct gagatctggg agggagagcc     3180

tccgtgtctc ccaccgaggg acagcctgaa ccagagcctc agccaggacc tcaccatggc     3240

ccctggctcc acactctggc tgtcctgtgg ggtaccccct gactctgtgt ccaggggccc     3300

cctctcctgg acccatgtgc accccaaggg gcctaagtca ttgctgagcc tagagctgaa     3360

ggacgatcgc ccggccagag atatgtgggt aatggagacg ggtctgttgt tgccccgggc     3420

cacagctcaa gacgctggaa agtattattg tcaccgtggc aacctgacca tgtcattcca     3480

cctggagatc actgctcggc cagtactatg gcactggctg ctgaggactg gtggctggaa     3540

ggtctcagct gtgactttgg cttatctgat cttctgcctg tgttcccttg tgggcattct     3600

tcatcttcaa agagccctgg tcctgaggag gaaaagaaag cgaatgactg accccaccag     3660

gagattc                                                               3667


<210>  20
<211>  2679
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-1074 scFv nucleic acid sequence- encoded region

<400>  20
atggattgga tttggcgcat tctgtttctg gtgggcgcgg cgaccggcgc gcatagcgaa       60

gtgcagctgg tggaaagcgg cggcggcgtg gtgcgcccgg gcggcagcct gcgcctgagc      120

tgcgcggcga gcggctttac ctttgatgat tatggcatga gctgggtgcg ccaggcgccg      180

ggcaaaggcc tggaatgggt gagcggcatt aactggaacg gcggcagcac cggctatgcg      240

gatagcgtga aaggccgctt taccattagc cgcgataacg cgaaaaacag cctgtatctg      300

cagatgaaca gcctgcgcgc ggaagatacc gcggtgtatt attgcgcgcg cggccgcagc      360

ctgctgtttg attattgggg ccagggcacc ctggtgaccg tgagccgcgg cggcggcggc      420

agcggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcag cagcgaactg      480

acccaggatc cggcggtgag cgtggcgctg ggccagaccg tgcgcattac ctgccagggc      540

gatagcctgc gcagctatta tgcgagctgg tatcagcaga aaccgggcca ggcgccggtg      600

ctggtgattt atggcaaaaa caaccgcccg agcggcattc cggatcgctt tagcggcagc      660

agcagcggca acaccgcgag cctgaccatt accggcgcgc aggcggaaga tgaagcggat      720

tattattgca acagccgcga tagcagcggc aaccatgtgg tgtttggcgg cggcaccaaa      780

ctgaccgtgg gcagcggcgg cggcggcagc caggtgcagc tgcaggaatc tgggcctgga      840

ctggtcaaac cctccgagac tctgagcgtc acttgttctg tgagcggcga ctctatgaac      900

aattactatt ggacatggat ccgacagagc ccaggcaagg ggctggagtg gatcggctac      960

atttctgaca gagaaagtgc tacttataac cctagcctga attccagggt ggtcatttca     1020

cgcgacacca gcaagaacca gctgtccctg aaactgaatt ctgtgacccc cgcagataca     1080

gccgtctact attgcgccac cgctcggaga ggacagcgga tctacggcgt ggtcagcttc     1140

ggggagttct tttactacta ctcaatggat gtctggggga aggggactac agtgaccgtc     1200

tcaagcgcct cgaccaaggg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc     1260

agcggcggcg gcggcagctc ctatgtcagg ccactgtccg tcgcactggg ggagaccgca     1320

agaattagct gtgggaggca ggcactgggg agcagggctg tccagtggta ccagcaccga     1380

ccaggacagg caccaatcct gctgatctac aacaatcagg accggccttc aggcatcccc     1440

gagagattca gcggaacacc cgatattaac tttggcacta gagctaccct gacaatcagc     1500

ggagtggagg caggcgacga agccgattac tattgccata tgtgggactc caggtctggg     1560

ttcagttggt catttggcgg agcaactcga ctgaccgtgc tgcgcaaacg ccgcggcagc     1620

ggcgcgacca actttagcct gctgaaacag gcgggcgatg tggaagaaaa cccgggcccg     1680

atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc     1740

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag     1800

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc     1860

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc     1920

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg     1980

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag     2040

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc     2100

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc     2160

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg     2220

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt     2280

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag     2340

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg     2400

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat     2460

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta     2520

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg     2580

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg     2640

aggaaaagaa agcgaatgac tgaccccacc aggagattc                            2679


<210>  21
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain constant region IgG3

<400>  21
accgtggcgg cgccgagcgt gtttattttt ccgccgagcg atgaacagct gaaaagcggc       60

accgcgagcg tggtgtgcct gctgaacaac ttttatccgc gcgaagcgaa agtgcagtgg      120

aaagtggata acgcgctgca gagcggcaac agccaggaaa gcgtgaccga acaggatagc      180

aaagatagca cctatagcct gagcagcacc ctgaccctga gcaaagcgga ttatgaaaaa      240

cataaagtgt atgcgtgcga agtgacccat cagggcctga gcagcccggt gaccaaaagc      300

tttaaccgcg gcgaatgc                                                    318


<210>  22
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain constant region

<400>  22
gcgagcacca aaggcccgag cgtgtttccg ctggcgccgt gcagccgcag caccagcggc       60

ggcaccgcgg cgctgggctg cctggtgaaa gattattttc cggaaccggt gaccgtgagc      120

tggaacagcg gcgcgctgac cagcggcgtg catacctttc cggcggtgct gcagagcagc      180

ggcctgtata gcctgagcag cgtggtgacc gtgccgagca gcagcctggg cacccagacc      240

tatacctgca acgtgaacca taaaccgagc aacaccaaag tggataaacg cgtggaactg      300

aaaaccccgc tgggcgatac cacccatacc tgcccgcgct gcccggaacc gaaaagctgc      360

gataccccgc cgccgtgccc gcgctgcccg gaaccgaaaa gctgcgatac cccgccgccg      420

tgcccgcgct gcccggaacc gaaaagctgc gataccccgc cgccgtgccc gcgctgcccg      480

gcgccggaac tgctgggcgg cccgagcgtg tttctgtttc cgccgaaacc gaaagatacc      540

ctgatgatta gccgcacccc ggaagtgacc tgcgtggtgg tggatgtgag ccatgaagat      600

ccggaagtgc agtttaaatg gtatgtggat ggcgtggaag tgcataacgc gaaaaccaaa      660

ccgcgcgaag aacagtataa cagcaccttt cgcgtggtga gcgtgctgac cgtgctgcat      720

caggattggc tgaacggcaa agaatataaa tgcaaagtga gcaacaaagc gctgccggcg      780

ccgattgaaa aaaccattag caaaaccaaa ggccagccgc gcgaaccgca ggtgtatacc      840

ctgccgccga gccgcgaaga aatgaccaaa aaccaggtga gcctgacctg cctggtgaaa      900

ggcttttatc cgagcgatat tgcggtggaa tgggaaagca gcggccagcc ggaaaacaac      960

tataacacca ccccgccgat gctggatagc gatggcagct tttttctgta tagcaaactg     1020

accgtggata aaagccgctg gcagcagggc aacattttta gctgcagcgt gatgcatgaa     1080

gcgctgcata accgctttac ccagaaaagc ctgagcctga gcccgggcaa a              1131


<210>  23
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-1074 variable light (VL) chain amino acid sequence

<400>  23

Ser Tyr Val Arg Pro Leu Ser Val Ala Leu Gly Glu Thr Ala Arg Ile 
1               5                   10                  15      


Ser Cys Gly Arg Gln Ala Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln 
            20                  25                  30          


His Arg Pro Gly Gln Ala Pro Ile Leu Leu Ile Tyr Asn Asn Gln Asp 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Thr Pro Asp Ile Asn 
    50                  55                  60                  


Phe Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys His Met Trp Asp Ser Arg Ser Gly Phe Ser 
                85                  90                  95      


Trp Ser Phe Gly Gly Ala Thr Arg Leu Thr Val Leu 
            100                 105             


<210>  24
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-1074 variable heavy (VH) chain amino acid sequence

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser Gly Asp Ser Met Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asp Arg Glu Ser Ala Thr Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Val Ile Ser Arg Asp Thr Ser Lys Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Ala Arg Arg Gly Gln Arg Ile Tyr Gly Val Val Ser Phe Gly Glu 
            100                 105                 110         


Phe Phe Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1.1

<400>  25

Gly Arg Gln Ala Leu Gly Ser Arg Ala Val Gln 
1               5                   10      


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2.1

<400>  26

Asn Asn Gln Asp Arg Pro Ser 
1               5           


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3.1

<400>  27

His Met Trp Asp Ser Arg Ser Gly Phe Ser Trp Ser 
1               5                   10          


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1.1

<400>  28

Asn Tyr Tyr Trp Thr 
1               5   


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2.1

<400>  29

Tyr Ile Ser Asp Arg Glu Ser Ala Thr Tyr Asn Pro Ser Leu Asn Ser 
1               5                   10                  15      


<210>  30
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3.1

<400>  30

Ala Arg Arg Gly Gln Arg Ile Tyr Gly Val Val Ser Phe Gly Glu Phe 
1               5                   10                  15      


Phe Tyr Tyr Tyr Ser Met Asp Val 
            20                  


<210>  31
<211>  988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter and spacer regions- Nucleic Acid

<400>  31
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg      540

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccatcggct      600

cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt      660

cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt      720

ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc      780

agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttaac ggtggagggc      840

agtgtagtct gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag      900

actaacagac tgttcctttc catgggtctt ttctgcagtc accgtcgtcg acacgtgtga      960

tcagatatcg cggccgctct agaccacc                                         988


<210>  32
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ANTIBODY SIGNAL SEQUENCE

<400>  32
atgggctgga gctgtatcat cctgttcctg gtggcaaccg caacaggagt gcacagc          57


<210>  33
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FURIN CLEAVAGE SITE- nucleic acid

<400>  33
cgcaaacgcc gc                                                           12


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FURIN CLEAVAGE SITE- amino acid

<400>  34

Arg Lys Arg Arg 
1               


<210>  35
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  35
agagccgagg gcaggggaag tcttctaaca tgcggggacg tggaggaaaa tcccgggccc       60


<210>  36
<211>  999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRUNCATED CD 19

<400>  36
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg      960

aggaaaagaa agcgaatgac tgaccccacc aggagattc                             999


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  37

Gly Gly Gly Gly 
1               


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  38

Gly Gly Gly Gly Gly 
1               5   


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  39

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  40

Gly Gly Gly Gly Gly Gly Gly 
1               5           


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  41

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  42

Gly Gly Gly Gly Ser 
1               5   


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  43

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  44

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  45

Thr Lys Gly Pro Ser 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  46

Thr Val Ala Ala Pro 
1               5   


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  47

Gln Pro Lys Ala Ala 
1               5   


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  48

Gln Arg Ile Glu Gly 
1               5   


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  49

Ala Ser Thr Lys Gly Pro Ser 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  50

Arg Thr Val Ala Ala Pro Ser 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  51

Gly Gln Pro Lys Ala Ala Pro 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  52

His Ile Asp Ser Pro Asn Lys 
1               5           


<210>  53
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-1074 variable light (VL) chain amino acid sequence - short 
       version

<400>  53

Ser Tyr Val Arg Pro Leu Ser Val Ala Leu Gly Glu Thr Ala Arg Ile 
1               5                   10                  15      


Ser Cys Gly Arg Gln Ala Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln 
            20                  25                  30          


His Arg Pro Gly Gln Ala Pro Ile Leu Leu Ile Tyr Asn Asn Gln Asp 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Thr Pro Asp Ile Asn 
    50                  55                  60                  


Phe Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr 
                85  


<210>  54
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding short version of 10-1074 variable light 
       (VL) chain

<400>  54
tcctacgtgc ggccactgtc cgtggccctg ggagagaccg caaggatctc ctgcggcaga       60

caggccctgg gatctagggc cgtgcagtgg tatcagcaca ggccaggaca ggcaccaatc      120

ctgctgatct acaacaatca ggaccggcct tctggcatcc cagagagatt cagcggcacc      180

cccgatatca actttggcac aagagccacc ctgacaatca gcggagtgga ggcaggcgac      240

gaggcagatt actattgtca catgtgggac agcaggtccg gcttctcttg gagctttggc      300

ggagcaacaa ggctgaccgt gctg                                             324


<210>  55
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-FR1

<400>  55

Ser Tyr Val Arg Pro Leu Ser Val Ala Leu Gly Glu Thr Ala Arg Ile 
1               5                   10                  15      


Ser Cys Gly Arg Gln 
            20      


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1.2

<400>  56

Ala Leu Gly Ser Arg Ala 
1               5       


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-FR2

<400>  57

Val Gln Trp Tyr Gln His Arg Pro Gly Gln Ala Pro Ile Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  58
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2.2

<400>  58

Asn Asn Gln 
1           


<210>  59
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-FR3

<400>  59

Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Thr Pro Asp Ile 
1               5                   10                  15      


Asn Phe Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly 
            20                  25                  30          


Asp Glu Ala Asp 
        35      


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3.2

<400>  60

Tyr Tyr Cys His Met Trp Asp Ser Arg Ser Gly Phe Ser Trp Ser 
1               5                   10                  15  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-FR4

<400>  61

Phe Gly Gly Ala Thr Arg Leu Thr Val Leu 
1               5                   10  


<210>  62
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding 10-1074 constant light (CL) chain

<400>  62
gtggcagcac catccgtgtt catctttccc ccttctgatg agcagctgaa gtccggcacc       60

gcctctgtgg tgtgcctgct gaacaatttc tatcctaggg aggccaaggt gcagtggaag      120

gtggacaacg ccctgcagag cggcaattcc caggagtctg tgaccgagca ggacagcaag      180

gattccacat actctctgtc tagcaccctg acactgagca aggccgatta tgagaagcac      240

aaggtgtacg cctgtgaggt gacccaccag ggcctgtcct ctcctgtgac aaagtccttc      300

aacaggggag agtgc                                                       315


<210>  63
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-1074 constant light (CL) chain amino acid sequence

<400>  63

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
1               5                   10                  15      


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
            20                  25                  30          


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
        35                  40                  45              


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
65                  70                  75                  80  


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
                85                  90                  95      


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105 


<210>  64
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-1074 variable heavy (VH) chain amino acid sequence - long 
       version

<400>  64

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser Gly Asp Ser Met Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asp Arg Glu Ser Ala Thr Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Val Ile Ser Arg Asp Thr Ser Lys Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Ala Arg Arg Gly Gln Arg Ile Tyr Gly Val Val Ser Phe Gly Glu 
            100                 105                 110         


Phe Phe Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135     


<210>  65
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding long version of 10-1074 variable heavy (VH)
       chain

<400>  65
caggtgcagc tgcaggagtc cggaccagga ctggtgaagc ctagcgagac cctgtccgtg       60

acatgctccg tgtctggcga tagcatgaac aattactatt ggacctggat caggcagtcc      120

cctggcaagg gactggagtg gatcggctat atctctgaca gagagagcgc cacctacaac      180

ccaagcctga atagccgggt ggtcatctcc cgcgatacat ctaagaacca gctgtctctg      240

aagctgaata gcgtgacccc cgccgacaca gccgtgtact attgcgcaac agcaaggagg      300

ggacagagga tctatggcgt ggtgagcttc ggcgagttct tttactatta ctccatggac      360

gtgtggggca agggcaccac agtgaccgtg agctccgcca gcaccaag                   408


<210>  66
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR1

<400>  66

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser 
            20                  25  


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1.2

<400>  67

Gly Asp Ser Met Asn Asn Tyr Tyr 
1               5               


<210>  68
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR2

<400>  68

Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2.2

<400>  69

Ile Ser Asp Arg Glu Ser Ala 
1               5           


<210>  70
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR3

<400>  70

Thr Tyr Asn Pro Ser Leu Asn Ser Arg Val Val Ile Ser Arg Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Leu Ser Leu Lys Leu Asn Ser Val Thr Pro Ala Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  71
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3.2

<400>  71

Ala Thr Ala Arg Arg Gly Gln Arg Ile Tyr Gly Val Val Ser Phe Gly 
1               5                   10                  15      


Glu Phe Phe Tyr Tyr Tyr Ser Met Asp Val 
            20                  25      


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR4

<400>  72

Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  73
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding 10-1074 constant heavy (CH) chain

<400>  73
gcctccacaa agggccctag cgtgtttcca ctggcaccat gcagccgctc cacctctgga       60

ggcacagccg ccctgggctg tctggtgaag gactacttcc ccgagcctgt gaccgtgtct      120

tggaacagcg gcgccctgac cagcggagtg cacacatttc cagccgtgct gcagtctagc      180

ggcctgtatt ccctgtcctc tgtggtgaca gtgcccagct cctctctggg cacccagaca      240

tacacctgta acgtgaatca caagcctagc aataccaagg tggacaagag ggtggagctg      300

aagacccctc tgggcgatac cacacacaca tgcccacggt gtccagagcc caagtcttgc      360

gacaccccac ccccttgccc cagatgtcct gagccaaaga gctgtgatac accaccccct      420

tgccctaggt gtcccgagcc taagtcctgc gacaccccac caccttgccc aaggtgtcca      480

gcaccagagc tgctgggagg accatccgtg ttcctgtttc cacccaagcc taaggataca      540

ctgatgatct ctcgcacccc agaggtgaca tgcgtggtgg tggacgtgag ccacgaggat      600

cccgaggtgc agttcaagtg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      660

ccccgggagg agcagtacaa ttccaccttt agagtggtgt ctgtgctgac agtgctgcac      720

caggattggc tgaacggcaa ggagtacaag tgtaaggtgt ccaataaggc cctgcctgcc      780

ccaatcgaga agaccatctc taagacaaag ggccagcctc gggagccaca ggtgtatacc      840

ctgcctccat ccagagagga gatgaccaag aaccaggtgt ctctgacatg cctggtgaag      900

ggcttctacc ccagcgatat cgcagtggag tgggagagct ccggacagcc tgagaacaat      960

tataatacca caccccctat gctggactcc gatggctctt tctttctgta ctctaagctg     1020

accgtggaca agagccggtg gcagcagggc aacatcttca gctgttccgt gatgcacgag     1080

gccctgcaca atcggtttac acagaagtct ctgagcctgt cccccggcaa g              1131


<210>  74
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-1074 constant heavy (HL) chain amino acid sequence

<400>  74

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  75
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant BiKE amino acid sequence (containing 10-1074 scFv)

<400>  75

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser Gly Asp Ser Met Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asp Arg Glu Ser Ala Thr Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Val Ile Ser Arg Asp Thr Ser Lys Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Ala Arg Arg Gly Gln Arg Ile Tyr Gly Val Val Ser Phe Gly Glu 
            100                 105                 110         


Phe Phe Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Arg 
145                 150                 155                 160 


Pro Leu Ser Val Ala Leu Gly Glu Thr Ala Arg Ile Ser Cys Gly Arg 
                165                 170                 175     


Gln Ala Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln His Arg Pro Gly 
            180                 185                 190         


Gln Ala Pro Ile Leu Leu Ile Tyr Asn Asn Gln Asp Arg Pro Ser Gly 
        195                 200                 205             


Ile Pro Glu Arg Phe Ser Gly Thr Pro Asp Ile Asn Phe Gly Thr Arg 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr 
    

<210>  76
<211>  1601
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid sequence of construct Genesis 605a

<400>  76
ggattagtcc aatttaccgg tacaagtttg tacaaaaaag caggctatgt acagaatgca       60

gctgctgagc tgcatcgccc tgagcctggc cctggtgacc aacagccagg tgcagctggt      120

ggagagcggc ggcggcctgg tgcagcccgg cggcagcctg agactgagct gcgccgccag      180

cggcttcacc ctggactact acagctggtt cagacaggcc cccggccagg gcctggaggc      240

cgtggcctgc atcagcgaca gcgacggcag aaccagattc acaatcagca gagacaacag      300

caagaacacc ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccgtgtacta      360

ctgcgccgcc accgactgca ccgtggaccc cagcctgctg tacgtgatgg actactgggg      420

ccagggcacc ctggtgaccg tgagcagcga ttacaaggac gacgacgata aggattacaa      480

ggatgatgat gataaggcga ccaactttag cctgctgaaa caggcgggcg acgtggaaga      540

aaacccgggc ccgatgccac ctcctcgcct cctcttcttc ctcctcttcc tcacccctat      600

ggaagtcagg cccgaggaac ctctagtggt gaaggtggaa gagggagata acgctgtgct      660

gcagtgcctc aaggggacct cagatggccc cactcagcag ctgacctggt ctcgggagtc      720

cccgcttaaa cccttcttaa aactcagcct ggggctgcca ggcctgggaa tccatatgag      780

gcccctggct atctggcttt ttatcttcaa cgtctctcaa cagatggggg gcttctacct      840

gtgccagccg gggcccccct ctgagaaggc ctggcagcct ggctggacag tcaatgtgga      900

gggcagcggg gagctgttcc ggtggaatgt ttcggaccta ggtggcctgg gctgtggcct      960

gaagaacagg tcctcagagg gccccagctc cccttccggg aagcttatga gccccaagct     1020

gtatgtgtgg gccaaagacc gccctgagat ctgggaggga gagcctccgt gtctcccacc     1080

gagggacagc ctgaaccaga gcctcagcca ggacctcaca atggcccctg gctccacact     1140

ctggctgtcc tgtggggtac cccctgactc tgtgtccagg ggccccctct cctggaccca     1200

cgtgcacccc aaggggccta agtcattgct gagcctagag ctgaaggacg atcgcccggc     1260

cagagatatg tgggtaatgg agacgggtct gttgttgccc cgggccacag ctcaagacgc     1320

tggaaagtat tattgtcacc gtggcaacct gaccatgtcc ttccacctgg agatcactgc     1380

tcggccagta ctctggcact ggctgctgag gactggtggc tggaaggtct cagctgtgac     1440

tttggcttat ctgatcttct gcctgtgttc ccttgtgggc attcttcatc ttcaaagagc     1500

cctggtcctg aggaggaaaa gaaagcgaat gactgacccc accaggagat tctaaaccac     1560

tttgtacaag aaagctgggt ctcgagggat tagtccaatt t                         1601


<210>  77
<211>  1982
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid sequence of construct Genesis 605b

<400>  77
ggattagtcc aatttaccgg tacaagtttg tacaaaaaag caggctatgt acagaatgca       60

gctgctgagc tgcatcgccc tgagcctggc cctggtgacc aacagcgagg tgcagctggt      120

ggagagcggc ggcggcctgg tgcagcccgg cggcagcctg agactgagct gcgccgccag      180

cggcttcacc ttcagcaact acggcatgag ctgggtgaga caggcccccg gcaagggcct      240

ggagtggatc ggcagcctgt actacagcgg cggcagcacc aactacaacc ccagcctgaa      300

gggcagcctg gtgatcagca gagacaacag caagaacacc ctgtacctgc agatgaacag      360

cctggccgag gacaccgcca cctactactg cgccagagag agcatcgact actggggcca      420

gggcaccctg gtgaccgtga gcagcggtgg cggatcagga ggcggaggtt ctggaggagg      480

tgggagtcag gtgcagctgg tggagagcgg cggcggcctg gtgcagcccg gcggcagcct      540

gagactgagc tgcgccgcca gcggcttcac cctggactac tacagctggt tcagacaggc      600

ccccggccag ggcctggagg ccgtggcctg catcagcgac agcgacggca gaaccagatt      660

cacaatcagc agagacaaca gcaagaacac cctgtacctg cagatgaaca gcctgagagc      720

cgaggacacc gccgtgtact actgcgccgc caccgactgc accgtggacc ccagcctgct      780

gtacgtgatg gactactggg gccagggcac cctggtgacc gtgagcagcg attacaagga      840

cgacgacgat aaggattaca aggatgatga tgataaggcg accaacttta gcctgctgaa      900

acaggcgggc gacgtggaag aaaacccggg cccgatgcca cctcctcgcc tcctcttctt      960

cctcctcttc ctcaccccta tggaagtcag gcccgaggaa cctctagtgg tgaaggtgga     1020

agagggagat aacgctgtgc tgcagtgcct caaggggacc tcagatggcc ccactcagca     1080

gctgacctgg tctcgggagt ccccgcttaa acccttctta aaactcagcc tggggctgcc     1140

aggcctggga atccatatga ggcccctggc tatctggctt tttatcttca acgtctctca     1200

acagatgggg ggcttctacc tgtgccagcc ggggcccccc tctgagaagg cctggcagcc     1260

tggctggaca gtcaatgtgg agggcagcgg ggagctgttc cggtggaatg tttcggacct     1320

aggtggcctg ggctgtggcc tgaagaacag gtcctcagag ggccccagct ccccttccgg     1380

gaagcttatg agccccaagc tgtatgtgtg ggccaaagac cgccctgaga tctgggaggg     1440

agagcctccg tgtctcccac cgagggacag cctgaaccag agcctcagcc aggacctcac     1500

aatggcccct ggctccacac tctggctgtc ctgtggggta ccccctgact ctgtgtccag     1560

gggccccctc tcctggaccc acgtgcaccc caaggggcct aagtcattgc tgagcctaga     1620

gctgaaggac gatcgcccgg ccagagatat gtgggtaatg gagacgggtc tgttgttgcc     1680

ccgggccaca gctcaagacg ctggaaagta ttattgtcac cgtggcaacc tgaccatgtc     1740

cttccacctg gagatcactg ctcggccagt actctggcac tggctgctga ggactggtgg     1800

ctggaaggtc tcagctgtga ctttggctta tctgatcttc tgcctgtgtt cccttgtggg     1860

cattcttcat cttcaaagag ccctggtcct gaggaggaaa agaaagcgaa tgactgaccc     1920

caccaggaga ttctaaacca ctttgtacaa gaaagctggg tctcgaggga ttagtccaat     1980

tt                                                                    1982


<210>  78
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain constant region IgG3 (amino acid)

<400>  78

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  79
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain constant region (amino acid)

<400>  79

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  80
<211>  10742
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA construct 101074 ALL


<220>
<221>  LTR
<222>  (1)..(592)
<223>  long terminal repeat from Moloney murine leukemia virus

<220>
<221>  misc_feature
<222>  (455)..(462)
<223>  UAS repeats

<220>
<221>  misc_feature
<222>  (655)..(1012)
<223>  MMLV Psi, packaging signal of Moloney murine leukemia virus 
       (MMLV)

<220>
<221>  misc_feature
<222>  (1833)..(6282)
<223>  101074 ALL

<220>
<221>  enhancer
<222>  (1839)..(2142)

<220>
<221>  promoter
<222>  (2143)..(2346)

<220>
<221>  CDS
<222>  (3547)..(3603)
<223>  2A peptide from porcine teschovirus-1 polyprotein (P2A)

<220>
<221>  CDS
<222>  (5221)..(5277)
<223>  2A peptide from porcine teschovirus-1 polyprotein (P2A)

<220>
<221>  LTR
<222>  (6547)..(7016)
<223>  long terminal repeat from Moloney murine leukemia virus

<220>
<221>  misc_feature
<222>  (6881)..(6888)
<223>  UAS repeats

<220>
<221>  primer_bind
<222>  (7715)..(7731)
<223>  M13 fwd, complement

<220>
<221>  promoter
<222>  (8206)..(8310)
<223>  bla promoter

<220>
<221>  CDS
<222>  (8311)..(9171)
<223>  beta-lactamase

<220>
<221>  misc_feature
<222>  (8729)..(8736)
<223>  UAS repeats

<220>
<221>  rep_origin
<222>  (9316)..(9989)
<223>  pUC origin

<220>
<221>  rep_origin
<222>  (9342)..(9936)
<223>  pMB1 replication origin

<220>
<221>  promoter
<222>  (10206)..(10327)
<223>  lac promoter

<220>
<221>  protein_bind
<222>  (10218)..(10239)
<223>  E. coli catabolite activator protein binding site

<220>
<221>  protein_bind
<222>  (10290)..(10310)
<223>  lac repressor binding site

<220>
<221>  primer_bind
<222>  (10316)..(10332)
<223>  M13 rev

<220>
<221>  LTR
<222>  (10741)..(10742)
<223>  long terminal repeat from Moloney murine leukemia virus

<400>  80
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaaatac ataactgaga atagaaaagt tcagatcaag gtcaggaaca gatggaacag      120

ctgaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa      180

gaacagatgg aacagctgaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc      240

ccggctcagg gccaagaaca gatggtcccc agatgcggtc cagccctcag cagtttctag      300

agaaccatca gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg      360

aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc ttatgctccc cgagctcaat      420

aaaagagccc acaacccctc actcggggcg ccagtcctcc gattgactga gtcgcccggg      480

tacccgtgta tccaataaac cctcttgcag ttgcatccga cttgtggtct cgctgttcct      540

tgggagggtc tcctctgagt gattgactac ccgtcagcgg gggtctttca tttgggggct      600

cgtccgggat cgggagaccc ctgcccaggg accaccgacc caccaccggg aggtaagctg      660

gccagcaact tatctgtgtc tgtccgattg tctagtgtct atgactgatt ttatgcgcct      720

gcgtcggtac tagttagcta actagctctg tatctggcgg acccgtggtg gaactgacga      780

gttcggaaca cccggccgca accctgggag acgtcccagg gacttcgggg gccgtttttg      840

tggcccgacc tgagtcctaa aatcccgatc gtttaggact ctttggtgca ccccccttag      900

aggagggata tgtggttctg gtaggagacg agaacctaaa acagttcccg cctccgtctg      960

aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg tcttgtctgc tgcagcatcg     1020

ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc tgaaaatatg ggcccgggct     1080

agcctgttac cactccctta agtttgacct taggtcactg gaaagatgtc gagcggatcg     1140

ctcacaacca gtcggtagat gtcaagaaga gacgttgggt taccttctgc tctgcagaat     1200

ggccaacctt taacgtcgga tggccgcgag acggcacctt taaccgagac ctcatcaccc     1260

aggttaagat caaggtcttt tcacctggcc cgcatggaca cccagaccag gtggggtaca     1320

tcgtgacctg ggaagccttg gcttttgacc cccctccctg ggtcaagccc tttgtacacc     1380

ctaagcctcc gcctcctctt cctccatccg ccccgtctct cccccttgaa cctcctcgtt     1440

cgaccccgcc tcgatcctcc ctttatccag ccctcactcc ttctctaggc gcccccatat     1500

ggccatatga gatcttatat ggggcacccc cgccccttgt aaacttccct gaccctgaca     1560

tgacaagagt tactaacagc ccctctctcc aagctcactt acaggctctc tacttagtcc     1620

agcacgaagt ctggagacct ctggcggcag cctaccaaga acaactggac cgaccggtgg     1680

tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg ccgacaccag actaagaacc     1740

tagaacctcg ctggaaagga ccttacacag tcctgctgac cacccccacc gccctcaaag     1800

tagacggcat cgcagcttgg atacacgccg cccacgtgcg ttacataact tacggtaaat     1860

ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt     1920

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa     1980

actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc     2040

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct     2100

acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag     2160

tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt     2220

gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac     2280

aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc     2340

agagctcgtt tagtgaaccg tcagatcgcc tggagacgcc atccacgctg ttttgacctc     2400

catagaagac accgggaccg atccagcctc catcggctcg catctctcct tcacgcgccc     2460

gccgccctac ctgaggccgc catccacgcc ggttgagtcg cgttctgccg cctcccgcct     2520

gtggtgcctc ctgaactgcg tccgccgtct aggtaagttt aaagctcagg tcgagaccgg     2580

gcctttgtcc ggcgctccct tggagcctac ctagactcag ccggctctcc acgctttgcc     2640

tgaccctgct tgctcaactc tagttaacgg tggagggcag tgtagtctga gcagtactcg     2700

ttgctgccgc gcgcgccacc agacataata gctgacagac taacagactg ttcctttcca     2760

tgggtctttt ctgcagtcac cgtcgtcgac acgtgtgatc agatatcgcg gccgctctag     2820

accaccatgg gctggagctg tatcatcctg ttcctggtgg caaccgcaac aggagtgcac     2880

agctcctacg tgcggccact gtccgtggcc ctgggagaga ccgcaaggat ctcctgcggc     2940

agacaggccc tgggatctag ggccgtgcag tggtatcagc acaggccagg acaggcacca     3000

atcctgctga tctacaacaa tcaggaccgg ccttctggca tcccagagag attcagcggc     3060

acccccgata tcaactttgg cacaagagcc accctgacaa tcagcggagt ggaggcaggc     3120

gacgaggcag attactattg tcacatgtgg gacagcaggt ccggcttctc ttggagcttt     3180

ggcggagcaa caaggctgac cgtgctgaca gtggcagcac catccgtgtt catctttccc     3240

ccttctgatg agcagctgaa gtccggcacc gcctctgtgg tgtgcctgct gaacaatttc     3300

tatcctaggg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaattcc     3360

caggagtctg tgaccgagca ggacagcaag gattccacat actctctgtc tagcaccctg     3420

acactgagca aggccgatta tgagaagcac aaggtgtacg cctgtgaggt gacccaccag     3480

ggcctgtcct ctcctgtgac aaagtccttc aacaggggag agtgcaggaa gaggagagga     3540

tctgga gca acc aac ttt agc ctg ctg aag cag gca ggc gac gtg gag        3588
       Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu            
       1               5                   10                             

gag aat cct gga cca atgggatggt cctgtatcat cctgtttctg gtcgccactg       3643
Glu Asn Pro Gly Pro                                                       
15                                                                        

ccacaggagt gcacagccag gtgcagctgc aggagtccgg accaggactg gtgaagccta     3703

gcgagaccct gtccgtgaca tgctccgtgt ctggcgatag catgaacaat tactattgga     3763

cctggatcag gcagtcccct ggcaagggac tggagtggat cggctatatc tctgacagag     3823

agagcgccac ctacaaccca agcctgaata gccgggtggt catctcccgc gatacatcta     3883

agaaccagct gtctctgaag ctgaatagcg tgacccccgc cgacacagcc gtgtactatt     3943

gcgcaacagc aaggagggga cagaggatct atggcgtggt gagcttcggc gagttctttt     4003

actattactc catggacgtg tggggcaagg gcaccacagt gaccgtgagc tccgccagca     4063

ccaaggcctc cacaaagggc cctagcgtgt ttccactggc accatgcagc cgctccacct     4123

ctggaggcac agccgccctg ggctgtctgg tgaaggacta cttccccgag cctgtgaccg     4183

tgtcttggaa cagcggcgcc ctgaccagcg gagtgcacac atttccagcc gtgctgcagt     4243

ctagcggcct gtattccctg tcctctgtgg tgacagtgcc cagctcctct ctgggcaccc     4303

agacatacac ctgtaacgtg aatcacaagc ctagcaatac caaggtggac aagagggtgg     4363

agctgaagac ccctctgggc gataccacac acacatgccc acggtgtcca gagcccaagt     4423

cttgcgacac cccaccccct tgccccagat gtcctgagcc aaagagctgt gatacaccac     4483

ccccttgccc taggtgtccc gagcctaagt cctgcgacac cccaccacct tgcccaaggt     4543

gtccagcacc agagctgctg ggaggaccat ccgtgttcct gtttccaccc aagcctaagg     4603

atacactgat gatctctcgc accccagagg tgacatgcgt ggtggtggac gtgagccacg     4663

aggatcccga ggtgcagttc aagtggtacg tggacggcgt ggaggtgcac aacgccaaga     4723

ccaagccccg ggaggagcag tacaattcca cctttagagt ggtgtctgtg ctgacagtgc     4783

tgcaccagga ttggctgaac ggcaaggagt acaagtgtaa ggtgtccaat aaggccctgc     4843

ctgccccaat cgagaagacc atctctaaga caaagggcca gcctcgggag ccacaggtgt     4903

ataccctgcc tccatccaga gaggagatga ccaagaacca ggtgtctctg acatgcctgg     4963

tgaagggctt ctaccccagc gatatcgcag tggagtggga gagctccgga cagcctgaga     5023

acaattataa taccacaccc cctatgctgg actccgatgg ctctttcttt ctgtactcta     5083

agctgaccgt ggacaagagc cggtggcagc agggcaacat cttcagctgt tccgtgatgc     5143

acgaggccct gcacaatcgg tttacacaga agtctctgag cctgtccccc ggcaagagaa     5203

agcggagagg cagcggc gcc acc aac ttc tcc ctg ctg aag cag gcc ggc        5253
                   Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly            
                   20                  25                  30             

gac gtg gaa gaa aat cca gga cct atgccaccac ctaggctgct gttctttctg      5307
Asp Val Glu Glu Asn Pro Gly Pro                                           
                35                                                        

ctgtttctga caccaatgga ggtgagaccc gaggagcctc tggtggtgaa ggtggaggag     5367

ggcgacaacg ccgtgctgca gtgcctgaag ggcaccagcg atggaccaac ccagcagctg     5427

acatggagcc gggagtcccc actgaagccc tttctgaagc tgtccctggg actgccagga     5487

ctgggcatcc acatgagacc cctggccatc tggctgttca tcttcaacgt gagccagcag     5547

atgggaggct tctacctgtg ccagccagga ccaccatccg agaaggcatg gcagccagga     5607

tggaccgtga acgtggaggg atctggcgag ctgtttaggt ggaatgtgag cgatctggga     5667

ggactgggat gcggcctgaa gaaccgctct agcgagggcc cttcctctcc atccggcaag     5727

ctgatgtctc ctaagctgta cgtgtgggcc aaggacaggc cagagatctg ggagggagag     5787

cctccatgtc tgccacctcg cgacagcctg aatcagtctc tgagccagga tctgaccatg     5847

gccccaggca gcacactgtg gctgtcctgc ggagtgccac cagattccgt gtctcggggc     5907

ccactgtcct ggacccatgt gcaccccaag ggccctaagt ctctgctgag cctggagctg     5967

aaggacgatc ggcctgccag agatatgtgg gtcatggaga ccggactgct gctgccaagg     6027

gccacagcac aggacgccgg caagtattac tgccaccgcg gcaacctgac catgagcttc     6087

cacctggaga tcacagcaag gcccgtgctg tggcactggc tgctgaggac cggaggatgg     6147

aaggtgagcg ccgtgacact ggcctacctg atcttctgcc tgtgctccct ggtgggcatc     6207

ctgcacctgc agagagccct ggtgctgagg cgcaagagga agcgcatgac cgaccctaca     6267

cggagattta tcgatccgga ttagtccaat ttgttaaaga caggatatca gtggtccagg     6327

ctctagtttt gactcaacaa tatcaccagc tgaagcctat agagtacgag ccatagataa     6387

aataaaagat tttatttagt ctccagaaaa aggggggaat gaaagacccc acctgtaggt     6447

ttggcaagct agcttaagta acgccatttt gcaaggcatg gaaaaataca taactgagaa     6507

tagagaagtt cagatcaagg tcaggaacag atggaacagc tgaatatggg ccaaacagga     6567

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatgga acagctgaat     6627

atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag     6687

atggtcccca gatgcggtcc agccctcagc agtttctaga gaaccatcag atgtttccag     6747

ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga actaaccaat cagttcgctt     6807

ctcgcttctg ttcgcgcgct tctgctcccc gagctcaata aaagagccca caacccctca     6867

ctcggggcgc cagtcctccg attgactgag tcgcccgggt acccgtgtat ccaataaacc     6927

ctcttgcagt tgcatccgac ttgtggtctc gctgttcctt gggagggtct cctctgagtg     6987

attgactacc cgtcagcggg ggtctttcac acatgcagca tgtatcaaaa ttaatttggt     7047

tttttttctt aagtatttac attaaatggc catagtactt aaagttacat tggcttcctt     7107

gaaataaaca tggagtattc agaatgtgtc ataaatattt ctaattttaa gatagtatct     7167

ccattggctt tctacttttt cttttatttt tttttgtcct ctgtcttcca tttgttgttg     7227

ttgttgtttg tttgtttgtt tgttggttgg ttggttaatt tttttttaaa gatcctacac     7287

tatagttcaa gctagactat tagctactct gtaacccagg gtgaccttga agtcatgggt     7347

agcctgctgt tttagccttc ccacatctaa gattacaggt atgagctatc atttttggta     7407

tattgattga ttgattgatt gatgtgtgtg tgtgtgattg tgtttgtgtg tgtgactgtg     7467

aaaatgtgtg tatgggtgtg tgtgaatgtg tgtatgtatg tgtgtgtgtg agtgtgtgtg     7527

tgtgtgtgtg catgtgtgtg tgtgtgactg tgtctatgtg tatgactgtg tgtgtgtgtg     7587

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttgtgaaa aaatattcta tggtagtgag     7647

agccaacgct ccggctcagg tgtcaggttg gtttttgaga cagagtcttt cacttagctt     7707

ggaattcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac     7767

ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca     7827

ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggcgcctg atgcggtatt     7887

ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct     7947

gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct     8007

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     8067

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gatgacgaaa gggcctcgtg     8127

atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc     8187

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     8247

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag     8307

agt atg agt att caa cat ttc cgt gtc gcc ctt att ccc ttt ttt gcg       8355
    Met Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala           
        40                  45                  50                        

gca ttt tgc ctt cct gtt ttt gct cac cca gaa acg ctg gtg aaa gta       8403
Ala Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val           
    55                  60                  65                            

aaa gat gct gaa gat cag ttg ggt gca cga gtg ggt tac atc gaa ctg       8451
Lys Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu           
70                  75                  80                  85            

gat ctc aac agc ggt aag atc ctt gag agt ttt cgc ccc gaa gaa cgt       8499
Asp Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg           
                90                  95                  100               

ttt cca atg atg agc act ttt aaa gtt ctg cta tgt ggc gcg gta tta       8547
Phe Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu           
            105                 110                 115                   

tcc cgt att gac gcc ggg caa gag caa ctc ggt cgc cgc ata cac tat       8595
Ser Arg Ile Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His Tyr           
        120                 125                 130                       

tct cag aat gac ttg gtt gag tac tca cca gtc aca gaa aag cat ctt       8643
Ser Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu           
    135                 140                 145                           

acg gat ggc atg aca gta aga gaa tta tgc agt gct gcc ata acc atg       8691
Thr Asp Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr Met           
150                 155                 160                 165           

agt gat aac act gcg gcc aac tta ctt ctg aca acg atc gga gga ccg       8739
Ser Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro           
                170                 175                 180               

aag gag cta acc gct ttt ttg cac aac atg ggg gat cat gta act cgc       8787
Lys Glu Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg           
            185                 190                 195                   

ctt gat cgt tgg gaa ccg gag ctg aat gaa gcc ata cca aac gac gag       8835
Leu Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu           
        200                 205                 210                       

cgt gac acc acg atg cct gta gca atg gca aca acg ttg cgc aaa cta       8883
Arg Asp Thr Thr Met Pro Val Ala Met Ala Thr Thr Leu Arg Lys Leu           
    215                 220                 225                           

tta act ggc gaa cta ctt act cta gct tcc cgg caa caa tta ata gac       8931
Leu Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp           
230                 235                 240                 245           

tgg atg gag gcg gat aaa gtt gca gga cca ctt ctg cgc tcg gcc ctt       8979
Trp Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala Leu           
                250                 255                 260               

ccg gct ggc tgg ttt att gct gat aaa tct gga gcc ggt gag cgt ggg       9027
Pro Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg Gly           
            265                 270                 275                   

tct cgc ggt atc att gca gca ctg ggg cca gat ggt aag ccc tcc cgt       9075
Ser Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg           
        280                 285                 290                       

atc gta gtt atc tac acg acg ggg agt cag gca act atg gat gaa cga       9123
Ile Val Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg           
    295                 300                 305                           

aat aga cag atc gct gag ata ggt gcc tca ctg att aag cat tgg taa       9171
Asn Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp               
310                 315                 320                               

ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt     9231

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag     9291

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct     9351

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     9411

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     9471

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct     9531

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     9591

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     9651

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     9711

ctgagatacc tacagcgtga gcattgagaa agcgccacgc ttcccgaagg gagaaaggcg     9771

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     9831

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     9891

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     9951

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct    10011

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga    10071

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg    10131

cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg    10191

aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta ggcaccccag    10251

gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt    10311

cacacaggaa acagctatga ccatgattac gccaagcttt gctcttagga gtttcctaat    10371

acatcccaaa ctcaaatata taaagcattt gacttgttct atgccctagg gggcgggggg    10431

aagctaagcc agcttttttt aacatttaaa atgttaattc cattttaaat gcacagatgt    10491

ttttatttca taagggtttc aatgtgcatg aatgctgcaa tattcctgtt accaaagcta    10551

gtataaataa aaatagataa acgtggaaat tacttagagt ttctgtcatt aacgtttcct    10611

tcctcagttg acaacataaa tgcgctgctg agcaagccag tttgcatctg tcaggatcaa    10671

tttcccatta tgccagtcat attaattact agtcaattag ttgattttta tttttgacat    10731

atacatgtga a                                                         10742


<210>  81
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  2A peptide from porcine teschovirus-1 polyprotein (P2A)

<400>  81

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  82
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  2A peptide from porcine teschovirus-1 polyprotein (P2A)

<400>  82

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  83
<211>  286
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta-lactamase

<400>  83

Met Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 
1               5                   10                  15      


Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 
            20                  25                  30          


Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp 
        35                  40                  45              


Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe 
    50                  55                  60                  


Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser 
65                  70                  75                  80  


Arg Ile Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His Tyr Ser 
                85                  90                  95      


Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu Thr 
            100                 105                 110         


Asp Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr Met Ser 
        115                 120                 125             


Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys 
    130                 135                 140                 


Glu Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg Leu 
145                 150                 155                 160 


Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg 
                165                 170                 175     


Asp Thr Thr Met Pro Val Ala Met Ala Thr Thr Leu Arg Lys Leu Leu 
            180                 185                 190         


Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp 
        195                 200                 205             


Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala Leu Pro 
    210                 215                 220                 


Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg Gly Ser 
225                 230                 235                 240 


Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile 
                245                 250                 255     


Val Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg Asn 
            260                 265                 270         


Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp 
        275                 280                 285     


<210>  84
<211>  9971
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA construct 101074 BIKE


<220>
<221>  LTR
<222>  (1)..(592)
<223>  long terminal repeat from Moloney murine leukemia virus

<220>
<221>  misc_feature
<222>  (455)..(462)
<223>  UAS repeats

<220>
<221>  misc_feature
<222>  (655)..(1012)
<223>  MMLV Psi, packaging signal of Moloney murine leukemia virus 
       (MMLV)

<220>
<221>  misc_feature
<222>  (1833)..(5511)
<223>  101074 SCFV

<220>
<221>  enhancer
<222>  (1839)..(2142)
<223>  CMV enhancer

<220>
<221>  promoter
<222>  (2143)..(2346)
<223>  CMV promoter

<220>
<221>  CDS
<222>  (4450)..(4506)
<223>  2A peptide from porcine teschovirus-1 polyprotein (P2A)

<220>
<221>  LTR
<222>  (5776)..(6245)
<223>  long terminal repeat from Moloney murine leukemia virus

<220>
<221>  misc_feature
<222>  (6110)..(6117)
<223>  UAS repeats

<220>
<221>  primer_bind
<222>  (6944)..(6960)
<223>  M13 fwd, complement

<220>
<221>  promoter
<222>  (7435)..(7539)
<223>  bla promoter

<220>
<221>  CDS
<222>  (7540)..(8400)
<223>  beta-lactamase

<220>
<221>  misc_feature
<222>  (7958)..(7965)
<223>  UAS repeats

<220>
<221>  rep_origin
<222>  (8545)..(9218)
<223>  pUC origin

<220>
<221>  rep_origin
<222>  (8571)..(9165)
<223>  pMB1 replication origin

<220>
<221>  promoter
<222>  (9435)..(9556)
<223>  lac promoter

<220>
<221>  protein_bind
<222>  (9447)..(9468)
<223>  E. coli catabolite activator protein binding site

<220>
<221>  protein_bind
<222>  (9519)..(9539)
<223>  lac repressor binding site

<220>
<221>  primer_bind
<222>  (9545)..(9561)
<223>  M13 rev

<220>
<221>  LTR
<222>  (9970)..(9971)
<223>  long terminal repeat from Moloney murine leukemia virus

<400>  84
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaaatac ataactgaga atagaaaagt tcagatcaag gtcaggaaca gatggaacag      120

ctgaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa      180

gaacagatgg aacagctgaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc      240

ccggctcagg gccaagaaca gatggtcccc agatgcggtc cagccctcag cagtttctag      300

agaaccatca gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg      360

aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc ttatgctccc cgagctcaat      420

aaaagagccc acaacccctc actcggggcg ccagtcctcc gattgactga gtcgcccggg      480

tacccgtgta tccaataaac cctcttgcag ttgcatccga cttgtggtct cgctgttcct      540

tgggagggtc tcctctgagt gattgactac ccgtcagcgg gggtctttca tttgggggct      600

cgtccgggat cgggagaccc ctgcccaggg accaccgacc caccaccggg aggtaagctg      660

gccagcaact tatctgtgtc tgtccgattg tctagtgtct atgactgatt ttatgcgcct      720

gcgtcggtac tagttagcta actagctctg tatctggcgg acccgtggtg gaactgacga      780

gttcggaaca cccggccgca accctgggag acgtcccagg gacttcgggg gccgtttttg      840

tggcccgacc tgagtcctaa aatcccgatc gtttaggact ctttggtgca ccccccttag      900

aggagggata tgtggttctg gtaggagacg agaacctaaa acagttcccg cctccgtctg      960

aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg tcttgtctgc tgcagcatcg     1020

ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc tgaaaatatg ggcccgggct     1080

agcctgttac cactccctta agtttgacct taggtcactg gaaagatgtc gagcggatcg     1140

ctcacaacca gtcggtagat gtcaagaaga gacgttgggt taccttctgc tctgcagaat     1200

ggccaacctt taacgtcgga tggccgcgag acggcacctt taaccgagac ctcatcaccc     1260

aggttaagat caaggtcttt tcacctggcc cgcatggaca cccagaccag gtggggtaca     1320

tcgtgacctg ggaagccttg gcttttgacc cccctccctg ggtcaagccc tttgtacacc     1380

ctaagcctcc gcctcctctt cctccatccg ccccgtctct cccccttgaa cctcctcgtt     1440

cgaccccgcc tcgatcctcc ctttatccag ccctcactcc ttctctaggc gcccccatat     1500

ggccatatga gatcttatat ggggcacccc cgccccttgt aaacttccct gaccctgaca     1560

tgacaagagt tactaacagc ccctctctcc aagctcactt acaggctctc tacttagtcc     1620

agcacgaagt ctggagacct ctggcggcag cctaccaaga acaactggac cgaccggtgg     1680

tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg ccgacaccag actaagaacc     1740

tagaacctcg ctggaaagga ccttacacag tcctgctgac cacccccacc gccctcaaag     1800

tagacggcat cgcagcttgg atacacgccg cccacgtgcg ttacataact tacggtaaat     1860

ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt     1920

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa     1980

actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc     2040

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct     2100

acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag     2160

tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt     2220

gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac     2280

aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc     2340

agagctcgtt tagtgaaccg tcagatcgcc tggagacgcc atccacgctg ttttgacctc     2400

catagaagac accgggaccg atccagcctc catcggctcg catctctcct tcacgcgccc     2460

gccgccctac ctgaggccgc catccacgcc ggttgagtcg cgttctgccg cctcccgcct     2520

gtggtgcctc ctgaactgcg tccgccgtct aggtaagttt aaagctcagg tcgagaccgg     2580

gcctttgtcc ggcgctccct tggagcctac ctagactcag ccggctctcc acgctttgcc     2640

tgaccctgct tgctcaactc tagttaacgg tggagggcag tgtagtctga gcagtactcg     2700

ttgctgccgc gcgcgccacc agacataata gctgacagac taacagactg ttcctttcca     2760

tgggtctttt ctgcagtcac cgtcgtcgac acgtgtgatc agatatcgcg gccgctctag     2820

accaccatgg actggatctg gaggatcctg ttcctggtgg gagcagcaac cggagcacac     2880

tccgaggtgc agctggtgga gtctggagga ggagtggtga ggcctggagg atccctgagg     2940

ctgtcttgcg cagcaagcgg cttcacattt gacgattacg gaatgtcttg ggtgcgccag     3000

gcaccaggca agggactgga gtgggtgagc ggcatcaact ggaatggagg aagcaccgga     3060

tatgcagact ccgtgaaggg caggttcaca atcagccgcg ataacgccaa gaattccctg     3120

tacctgcaga tgaactctct gcgggccgag gacaccgccg tgtactattg cgcccggggc     3180

agatccctgc tgtttgatta ctggggccag ggcaccctgg tgacagtgtc tagaggcggc     3240

ggcggcagcg gcggcggcgg ctctggagga ggaggaagcg gaggaggagg aagctcctct     3300

gagctgacac aggacccagc cgtgagcgtg gccctgggac agaccgtgag gatcacatgt     3360

cagggcgatt ctctgcgcag ctactatgcc tcctggtatc agcagaagcc aggacaggca     3420

cccgtgctgg tcatctacgg caagaacaat cggccaagcg gcatccccga cagattctcc     3480

ggcagctcct ctggcaatac cgcctctctg accatcacag gagcacaggc agaggacgag     3540

gcagattact attgcaactc cagggatagc tccggcaatc atgtggtgtt cggcggcggc     3600

accaagctga cagtgggatc cggaggagga ggatctcagg tgcagctgca ggagagcgga     3660

ccaggactgg tgaagccatc cgagaccctg tctgtgacat gttccgtgtc tggcgactcc     3720

atgaacaatt actattggac ctggatccgg cagtctccag gcaagggcct ggagtggatc     3780

ggctatatca gcgatagaga gtccgccacc tacaacccct ccctgaatag ccgggtggtc     3840

atctctagag acacaagcaa gaaccagctg agcctgaagc tgaattccgt gacccccgcc     3900

gatacagccg tgtactattg tgccacagcc cggagaggcc agcggatcta tggcgtggtg     3960

agcttcggcg agttctttta ctattactcc atggacgtgt ggggcaaggg caccacagtg     4020

accgtgtcta gcgccagcac aaagggagga ggaggatcag gcggcggcgg cagtggcggc     4080

ggcggctccg gaggaggagg atcctcttac gtgagacctc tgtccgtggc cctgggagag     4140

accgcaagga tctcctgcgg ccgccaggcc ctgggatctc gggccgtgca gtggtatcag     4200

cacagacctg gccaggcccc aatcctgctg atctacaaca atcaggacag gccctctgga     4260

atccctgagc ggttcagcgg aaccccagat atcaactttg gcacaagggc caccctgaca     4320

atcagcggag tggaggcagg cgacgaggca gattattact gtcacatgtg ggacagccgc     4380

tccggcttct cttggagctt tggcggagca accaggctga cagtgctgag aaagaggagg     4440

ggatctgga gca acc aac ttc agc ctg ctg aag cag gcc ggc gat gtg gag     4491
          Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu         
          1               5                   10                          

gag aat cca gga cca atgccacctc caaggctgct gttctttctg ctgtttctga       4546
Glu Asn Pro Gly Pro                                                       
15                                                                        

cccccatgga ggtgagacct gaggagccac tggtggtgaa ggtggaggag ggcgacaacg     4606

ccgtgctgca gtgcctgaag ggcacaagcg atggccctac ccagcagctg acatggagcc     4666

gggagtcccc cctgaagcct ttcctgaagc tgtccctggg actgcctgga ctgggcatcc     4726

acatgagacc actggccatc tggctgttca tctttaatgt gagccagcag atgggaggct     4786

tctatctgtg ccagccagga ccaccttccg agaaggcatg gcagcctgga tggaccgtga     4846

acgtggaggg ctctggcgag ctgtttaggt ggaatgtgag cgacctggga ggactgggat     4906

gtggcctgaa gaaccgcagc tccgagggac catctagccc atctggcaag ctgatgagcc     4966

caaagctgta cgtgtgggcc aaggataggc cagagatctg ggagggagag ccaccatgcc     5026

tgcctccacg cgacagcctg aatcagtccc tgtctcagga tctgaccatg gcccccggct     5086

ccacactgtg gctgtcttgt ggagtgccac ctgacagcgt gtccaggggc cctctgtcct     5146

ggacccatgt gcaccctaag ggcccaaagt ctctgctgag cctggagctg aaggacgatc     5206

ggcctgccag agacatgtgg gtcatggaga ccggactgct gctgccaagg gccacagcac     5266

aggatgccgg caagtattac tgtcaccgcg gcaacctgac catgagcttt cacctggaga     5326

tcacagcaag gccagtgctg tggcactggc tgctgagaac cggaggatgg aaggtgagcg     5386

ccgtgacact ggcctacctg atcttctgcc tgtgctccct ggtgggaatc ctgcacctgc     5446

agcgcgccct ggtgctgcgg agaaagagga agcgcatgac cgatcccaca aggcgcttta     5506

tcgatccgga ttagtccaat ttgttaaaga caggatatca gtggtccagg ctctagtttt     5566

gactcaacaa tatcaccagc tgaagcctat agagtacgag ccatagataa aataaaagat     5626

tttatttagt ctccagaaaa aggggggaat gaaagacccc acctgtaggt ttggcaagct     5686

agcttaagta acgccatttt gcaaggcatg gaaaaataca taactgagaa tagagaagtt     5746

cagatcaagg tcaggaacag atggaacagc tgaatatggg ccaaacagga tatctgtggt     5806

aagcagttcc tgccccggct cagggccaag aacagatgga acagctgaat atgggccaaa     5866

caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag atggtcccca     5926

gatgcggtcc agccctcagc agtttctaga gaaccatcag atgtttccag ggtgccccaa     5986

ggacctgaaa tgaccctgtg ccttatttga actaaccaat cagttcgctt ctcgcttctg     6046

ttcgcgcgct tctgctcccc gagctcaata aaagagccca caacccctca ctcggggcgc     6106

cagtcctccg attgactgag tcgcccgggt acccgtgtat ccaataaacc ctcttgcagt     6166

tgcatccgac ttgtggtctc gctgttcctt gggagggtct cctctgagtg attgactacc     6226

cgtcagcggg ggtctttcac acatgcagca tgtatcaaaa ttaatttggt tttttttctt     6286

aagtatttac attaaatggc catagtactt aaagttacat tggcttcctt gaaataaaca     6346

tggagtattc agaatgtgtc ataaatattt ctaattttaa gatagtatct ccattggctt     6406

tctacttttt cttttatttt tttttgtcct ctgtcttcca tttgttgttg ttgttgtttg     6466

tttgtttgtt tgttggttgg ttggttaatt tttttttaaa gatcctacac tatagttcaa     6526

gctagactat tagctactct gtaacccagg gtgaccttga agtcatgggt agcctgctgt     6586

tttagccttc ccacatctaa gattacaggt atgagctatc atttttggta tattgattga     6646

ttgattgatt gatgtgtgtg tgtgtgattg tgtttgtgtg tgtgactgtg aaaatgtgtg     6706

tatgggtgtg tgtgaatgtg tgtatgtatg tgtgtgtgtg agtgtgtgtg tgtgtgtgtg     6766

catgtgtgtg tgtgtgactg tgtctatgtg tatgactgtg tgtgtgtgtg tgtgtgtgtg     6826

tgtgtgtgtg tgtgtgtgtg tgttgtgaaa aaatattcta tggtagtgag agccaacgct     6886

ccggctcagg tgtcaggttg gtttttgaga cagagtcttt cacttagctt ggaattcact     6946

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     7006

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     7066

ttcccaacag ttgcgcagcc tgaatggcga atggcgcctg atgcggtatt ttctccttac     7126

gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc     7186

cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg     7246

tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca     7306

gaggttttca ccgtcatcac cgaaacgcgc gatgacgaaa gggcctcgtg atacgcctat     7366

ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg     7426

gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc     7486

tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agt atg        7542
                                                           Met            
                                                           20             

agt att caa cat ttc cgt gtc gcc ctt att ccc ttt ttt gcg gca ttt       7590
Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala Phe           
                25                  30                  35                

tgc ctt cct gtt ttt gct cac cca gaa acg ctg gtg aaa gta aaa gat       7638
Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys Asp           
            40                  45                  50                    

gct gaa gat cag ttg ggt gca cga gtg ggt tac atc gaa ctg gat ctc       7686
Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp Leu           
        55                  60                  65                        

aac agc ggt aag atc ctt gag agt ttt cgc ccc gaa gaa cgt ttt cca       7734
Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe Pro           
    70                  75                  80                            

atg atg agc act ttt aaa gtt ctg cta tgt ggc gcg gta tta tcc cgt       7782
Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser Arg           
85                  90                  95                  100           

att gac gcc ggg caa gag caa ctc ggt cgc cgc ata cac tat tct cag       7830
Ile Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His Tyr Ser Gln           
                105                 110                 115               

aat gac ttg gtt gag tac tca cca gtc aca gaa aag cat ctt acg gat       7878
Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu Thr Asp           
            120                 125                 130                   

ggc atg aca gta aga gaa tta tgc agt gct gcc ata acc atg agt gat       7926
Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr Met Ser Asp           
        135                 140                 145                       

aac act gcg gcc aac tta ctt ctg aca acg atc gga gga ccg aag gag       7974
Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys Glu           
    150                 155                 160                           

cta acc gct ttt ttg cac aac atg ggg gat cat gta act cgc ctt gat       8022
Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg Leu Asp           
165                 170                 175                 180           

cgt tgg gaa ccg gag ctg aat gaa gcc ata cca aac gac gag cgt gac       8070
Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg Asp           
                185                 190                 195               

acc acg atg cct gta gca atg gca aca acg ttg cgc aaa cta tta act       8118
Thr Thr Met Pro Val Ala Met Ala Thr Thr Leu Arg Lys Leu Leu Thr           
            200                 205                 210                   

ggc gaa cta ctt act cta gct tcc cgg caa caa tta ata gac tgg atg       8166
Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp Met           
        215                 220                 225                       

gag gcg gat aaa gtt gca gga cca ctt ctg cgc tcg gcc ctt ccg gct       8214
Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala Leu Pro Ala           
    230                 235                 240                           

ggc tgg ttt att gct gat aaa tct gga gcc ggt gag cgt ggg tct cgc       8262
Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg Gly Ser Arg           
245                 250                 255                 260           

ggt atc att gca gca ctg ggg cca gat ggt aag ccc tcc cgt atc gta       8310
Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile Val           
                265                 270                 275               

gtt atc tac acg acg ggg agt cag gca act atg gat gaa cga aat aga       8358
Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg Asn Arg           
            280                 285                 290                   

cag atc gct gag ata ggt gcc tca ctg att aag cat tgg taa               8400
Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp                       
        295                 300                 305                       

ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt     8460

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag     8520

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct     8580

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     8640

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     8700

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct     8760

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     8820

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     8880

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     8940

ctgagatacc tacagcgtga gcattgagaa agcgccacgc ttcccgaagg gagaaaggcg     9000

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     9060

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     9120

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     9180

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct     9240

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga     9300

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg     9360

cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg     9420

aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta ggcaccccag     9480

gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt     9540

cacacaggaa acagctatga ccatgattac gccaagcttt gctcttagga gtttcctaat     9600

acatcccaaa ctcaaatata taaagcattt gacttgttct atgccctagg gggcgggggg     9660

aagctaagcc agcttttttt aacatttaaa atgttaattc cattttaaat gcacagatgt     9720

ttttatttca taagggtttc aatgtgcatg aatgctgcaa tattcctgtt accaaagcta     9780

gtataaataa aaatagataa acgtggaaat tacttagagt ttctgtcatt aacgtttcct     9840

tcctcagttg acaacataaa tgcgctgctg agcaagccag tttgcatctg tcaggatcaa     9900

tttcccatta tgccagtcat attaattact agtcaattag ttgattttta tttttgacat     9960

atacatgtga a                                                          9971


<210>  85
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  2A peptide from porcine teschovirus-1 polyprotein (P2A)

<400>  85

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  86
<211>  286
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta-lactamase

<400>  86

Met Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 
1               5                   10                  15      


Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 
            20                  25                  30          


Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp 
        35                  40                  45              


Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe 
    50                  55                  60                  


Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser 
65                  70                  75                  80  


Arg Ile Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His Tyr Ser 
                85                  90                  95      


Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu Thr 
            100                 105                 110         


Asp Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr Met Ser 
        115                 120                 125             


Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys 
    130                 135                 140                 


Glu Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg Leu 
145                 150                 155                 160 


Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg 
                165                 170                 175     


Asp Thr Thr Met Pro Val Ala Met Ala Thr Thr Leu Arg Lys Leu Leu 
            180                 185                 190         


Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp 
        195                 200                 205             


Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala Leu Pro 
    210                 215                 220                 


Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg Gly Ser 
225                 230                 235                 240 


Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile 
                245                 250                 255     


Val Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg Asn 
            260                 265                 270         


Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp 
        275                 280                 285     


