                               SEQUENCE LISTING

<110> UNIVERSITY OF NEW ENGLAND
 
<120> METHODS AND DIAGNOSTICS FOR CANCER DETECTION AND TREATMENT 
      MONITORING

<130> 162234-010304 

<140> PCT/US2019/051124
<141> 2019-09-13

<150> 62/840,581
<151> 2019-04-30

<150> 62/754,053
<151> 2018-11-01

<150> 62/731,269
<151> 2018-09-14

<160> 66    

<170> PatentIn version 3.5

<210> 1
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
1               5                   10                  15      


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
        35                  40                  45              


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
65                  70                  75                  80  


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
                85                  90                  95      


Ile Val Lys Ala Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Lys Thr Ser Thr Ser 
1               5   


<210> 3

<400> 3
000


<210> 4
<211> 396
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atgatggtgt taagtcttct gtacctgttg acagccattc ctggtatcct gtctgatgta       60

cagcttcagg agtcaggacc tggcctcgtg aaaccttctc agtctctgtc tctcacctgc      120

tctgtcactg gctactccat caccagtggt tattactgga actggatccg gcagtttcca      180

ggaaacaaac tggaatggat gggctacaca aactacgacg gtagcaataa ctacaaccca      240

tctctcaaaa atcgaatctc catcactcgt gacacatcta agaaccagtt tttcctgaag      300

ttgaattctg tgactactga ggacacaggt acatattact gtgcgggacc ctaccttgac      360

tactggggcc aaggcaccac tctcacagtc tcctca                                396


<210> 5

<400> 5
000


<210> 6
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Met Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Thr Asn Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Gly Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Gly Pro Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210> 7

<400> 7
000


<210> 8
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
agtggttatt actggaac                                                     18


<210> 9

<400> 9
000


<210> 10
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
tacacaaact acgacggtag caataactac aacccatctc tcaaaaat                    48


<210> 11

<400> 11
000


<210> 12
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
ccctaccttg actac                                                        15


<210> 13

<400> 13
000


<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Ser Gly Tyr Tyr Trp Asn 
1               5       


<210> 15

<400> 15
000


<210> 16
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Tyr Thr Asn Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210> 17

<400> 17
000


<210> 18
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Pro Tyr Leu Asp Tyr 
1               5   


<210> 19

<400> 19
000


<210> 20
<211> 423
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
atggaatgga gcgggatctt tctctttctc ctgtcaggaa ctgcaggtgt ccactttgag       60

gtccagctgc agcagtctgg acctgagctg gtaaagcctg gggcttcagt gaagatgtcc      120

tgcaaggctt ctggatacaa attcactagc aatgttatgc actgggtgaa gcagaagcct      180

gggcagggcc ttgagtggat tggatatatt aatccttaca atgatggtac taagtacaat      240

gagaagttca aaggcaaggc cacactgact tcagacaaat cctccagcac agcctacatg      300

gagctcagca gcctgacctc tgaggactct gcggtctatt actgtggaag acattttgat      360

tactacggta ggggctacgc tgtggactac tggggtcaag gaacctcagt caccgtctcc      420

tca                                                                    423


<210> 21

<400> 21
000


<210> 22
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Glu Trp Ser Gly Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Phe Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe 
        35                  40                  45              


Thr Ser Asn Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gly Arg His Phe Asp Tyr Tyr Gly Arg Gly Tyr Ala Val 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140     


<210> 23

<400> 23
000


<210> 24
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
agcaatgtta tgcac                                                        15


<210> 25

<400> 25
000


<210> 26
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
tatattaatc cttacaatga tggtactaag tacaatgaga agttcaaagg c                51


<210> 27

<400> 27
000


<210> 28
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
cattttgatt actacggtag gggctacgct gtggactac                              39


<210> 29

<400> 29
000


<210> 30
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Ser Asn Val Met His 
1               5   


<210> 31

<400> 31
000


<210> 32
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 33

<400> 33
000


<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
His Phe Asp Tyr Tyr Gly Arg Gly Tyr Ala Val Asp Tyr 
1               5                   10              


<210> 35

<400> 35
000


<210> 36
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
atggattttc aggtgcagat tatcagcttc atgctaatca gtgtcacagt catgttgtcc       60

agtggagaaa ttgtgctcac acagtctcca gcactcatgg ctgcatctcc aggggagaag      120

gtcaccatca cctgcagtgt cagctcaagt ataagttcca gctacttaca ctggtaccag      180

cagaggtcag aaacctcccc caaaccctgg atttatggca catccaacct ggcttctgga      240

gtccctgttc gcttcagtgg caatggatct gggacctctt attctctcac aataagcagc      300

atggaggctg aagatgctgc cacttattac tgtcaacagt ggagtagtta cccactcacg      360

ttcggagggg ggaccaagct ggaaataaaa                                       390


<210> 37

<400> 37
000


<210> 38
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Asp Phe Gln Val Gln Ile Ile Ser Phe Met Leu Ile Ser Val Thr 
1               5                   10                  15      


Val Met Leu Ser Ser Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Leu 
            20                  25                  30          


Met Ala Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Tyr Leu His Trp Tyr Gln Gln Arg Ser Glu 
    50                  55                  60                  


Thr Ser Pro Lys Pro Trp Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Val Arg Phe Ser Gly Asn Gly Ser Gly Thr Ser Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Trp Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys 
    130 


<210> 39

<400> 39
000


<210> 40
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
agtgtcagct caagtataag ttccagctac ttacac                                 36


<210> 41

<400> 41
000


<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
ggcacatcca acctggcttc t                                                 21


<210> 43

<400> 43
000


<210> 44
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
caacagtgga gtagttaccc actcacg                                           27


<210> 45

<400> 45
000


<210> 46
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Ser Val Ser Ser Ser Ile Ser Ser Ser Tyr Leu His 
1               5                   10          


<210> 47

<400> 47
000


<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210> 49

<400> 49
000


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210> 51

<400> 51
000


<210> 52
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 52
atggtgtcct cagctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gtgcaagtca ggacattagc aattatttaa actggtatca acggaaacca      180

gatggaactg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct      300

gaagatattg ccacttacta ttgtctgcag tatagtaagc ttccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210> 53

<400> 53
000


<210> 54
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Arg Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Ser 
            100                 105                 110         


Lys Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210> 55

<400> 55
000


<210> 56
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
agtgcaagtc aggacattag caattattta aac                                    33


<210> 57

<400> 57
000


<210> 58
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
tacacatcaa gtttacactc a                                                 21


<210> 59

<400> 59
000


<210> 60
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
ctgcagtata gtaagcttcc gtggacg                                           27


<210> 61

<400> 61
000


<210> 62
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210> 63

<400> 63
000


<210> 64
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Tyr Thr Ser Ser Leu His Ser 
1               5           


<210> 65

<400> 65
000


<210> 66
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Leu Gln Tyr Ser Lys Leu Pro Trp Thr 
1               5                   


