SEQUENCE LISTING

<110>   Translate Bio, Inc.

<120>   COMPOSITION AND METHODS FOR TREATMENT OF METHYLMALONIC ACIDEMIA

<130>   MRT-2014WO

<141>   2019-09-13

<150>   62/793,221
<151>   2019-01-16

<150>   62/731,481
<151>   2018-09-14

<160>   12

<170>   SeqWin2010, version 1.0

<210>   1
<211>   2253
<212>   RNA
<213>   Homo sapiens

<400>   1
auguuaagag cuaagaauca gcuuuuuuua cuuucaccuc auuaccugag gcagguaaaa  60
gaaucaucag gcuccaggcu cauacagcaa cgacuucuac accagcaaca gccccuucac  120
ccagaauggg cugcccuggc uaaaaagcag cugaaaggca aaaacccaga agaccuaaua  180
uggcacaccc cggaagggau cucuauaaaa cccuuguauu ccaagagaga uacuauggac  240
uuaccugaag aacuuccagg agugaagcca uucacacgug gaccauaucc uaccauguau  300
accuuuaggc ccuggaccau ccgccaguau gcugguuuua guacugugga agaaagcaau  360
aaguucuaua aggacaacau uaaggcuggu cagcagggau uaucaguugc cuuugaucug  420
gcgacacauc guggcuauga uucagacaac ccucgaguuc guggugaugu uggaauggcu  480
ggaguugcua uugacacugu ggaagauacc aaaauucuuu uugauggaau uccuuuagaa  540
aaaaugucag uuuccaugac uaugaaugga gcaguuauuc caguucuugc aaauuuuaua  600
guaacuggag aagaacaagg uguaccuaaa gagaagcuua cugguaccau ccaaaaugau  660
auacuaaagg aauuuauggu ucgaaauaca uacauuuuuc cuccagaacc auccaugaaa  720
auuauugcug acauauuuga auauacagca aagcacaugc caaaauuuaa uucaauuuca  780
auuaguggau accauaugca ggaagcaggg gcugaugcca uucuggagcu ggccuauacu  840
uuagcagaug gauuggagua cucuagaacu ggacuccagg cuggccugac aauugaugaa  900
uuugcaccaa gguugucuuu cuucugggga auuggaauga auuucuauau ggaaauagca  960
aagaugagag cugguagaag acucugggcu cacuuaauag agaaaauguu ucagccuaaa  1020
aacucaaaau cucuucuucu aagagcacac ugucagacau cuggaugguc acuuacugag  1080
caggaucccu acaauaauau uguccguacu gcaauagaag caauggcagc aguauuugga  1140
gggacucagu cuuugcacac aaauucuuuu gaugaagcuu uggguuugcc aacugugaaa  1200
agugcucgaa uugccaggaa cacacaaauc aucauucaag aagaaucugg gauucccaaa  1260
guggcugauc cuuggggagg uucuuacaug auggaauguc ucacaaauga uguuuaugau  1320
gcugcuuuaa agcucauuaa ugaaauugaa gaaaugggug gaauggccaa agcuguagcu  1380
gagggaauac cuaaacuucg aauugaagaa ugugcugccc gaagacaagc uagaauagau  1440
ucugguucug aaguaauugu uggaguaaau aaguaccagu uggaaaaaga agacgcugua  1500
gaaguucugg caauugauaa uacuucagug cgaaacaggc agauugaaaa acuuaagaag  1560
aucaaaucca gcagggauca agcuuuggcu gaacguuguc uugcugcacu aaccgaaugu  1620
gcugcuagcg gagauggaaa uauccuggcu cuugcagugg augcaucucg ggcaagaugu  1680
acagugggag aaaucacaga ugcccugaaa aagguauuug gugaacauaa agcgaaugau  1740
cgaaugguga guggagcaua ucgccaggaa uuuggagaaa guaaagagau aacaucugcu  1800
aucaagaggg uucauaaauu cauggaacgu gaaggucgca gaccucgucu ucuuguagca  1860
aaaaugggac aagauggcca ugacagagga gcaaaaguua uugcuacagg auuugcugau  1920
cuugguuuug auguggacau aggcccucuu uuccagacuc cucgugaagu ggcccagcag  1980
gcuguggaug cggaugugca ugcugugggc auaagcaccc ucgcugcugg ucauaaaacc  2040
cuaguuccug aacucaucaa agaacuuaac ucccuuggac ggccagauau ucuugucaug  2100
uguggagggg ugauaccacc ucaggauuau gaauuucugu uugaaguugg uguuuccaau  2160
guauuugguc cugggacucg aauuccaaag gcugccguuc aggugcuuga ugauauugag  2220
aaguguuugg aaaagaagca gcaaucugua uaa                               2253

<210>   2
<211>   2253
<212>   DNA
<213>   Homo sapiens

<400>   2
atgttaagag ctaagaatca gcttttttta ctttcacctc attacctgag gcaggtaaaa  60
gaatcatcag gctccaggct catacagcaa cgacttctac accagcaaca gccccttcac  120
ccagaatggg ctgccctggc taaaaagcag ctgaaaggca aaaacccaga agacctaata  180
tggcacaccc cggaagggat ctctataaaa cccttgtatt ccaagagaga tactatggac  240
ttacctgaag aacttccagg agtgaagcca ttcacacgtg gaccatatcc taccatgtat  300
acctttaggc cctggaccat ccgccagtat gctggtttta gtactgtgga agaaagcaat  360
aagttctata aggacaacat taaggctggt cagcagggat tatcagttgc ctttgatctg  420
gcgacacatc gtggctatga ttcagacaac cctcgagttc gtggtgatgt tggaatggct  480
ggagttgcta ttgacactgt ggaagatacc aaaattcttt ttgatggaat tcctttagaa  540
aaaatgtcag tttccatgac tatgaatgga gcagttattc cagttcttgc aaattttata  600
gtaactggag aagaacaagg tgtacctaaa gagaagctta ctggtaccat ccaaaatgat  660
atactaaagg aatttatggt tcgaaataca tacatttttc ctccagaacc atccatgaaa  720
attattgctg acatatttga atatacagca aagcacatgc caaaatttaa ttcaatttca  780
attagtggat accatatgca ggaagcaggg gctgatgcca ttctggagct ggcctatact  840
ttagcagatg gattggagta ctctagaact ggactccagg ctggcctgac aattgatgaa  900
tttgcaccaa ggttgtcttt cttctgggga attggaatga atttctatat ggaaatagca  960
aagatgagag ctggtagaag actctgggct cacttaatag agaaaatgtt tcagcctaaa  1020
aactcaaaat ctcttcttct aagagcacac tgtcagacat ctggatggtc acttactgag  1080
caggatccct acaataatat tgtccgtact gcaatagaag caatggcagc agtatttgga  1140
gggactcagt ctttgcacac aaattctttt gatgaagctt tgggtttgcc aactgtgaaa  1200
agtgctcgaa ttgccaggaa cacacaaatc atcattcaag aagaatctgg gattcccaaa  1260
gtggctgatc cttggggagg ttcttacatg atggaatgtc tcacaaatga tgtttatgat  1320
gctgctttaa agctcattaa tgaaattgaa gaaatgggtg gaatggccaa agctgtagct  1380
gagggaatac ctaaacttcg aattgaagaa tgtgctgccc gaagacaagc tagaatagat  1440
tctggttctg aagtaattgt tggagtaaat aagtaccagt tggaaaaaga agacgctgta  1500
gaagttctgg caattgataa tacttcagtg cgaaacaggc agattgaaaa acttaagaag  1560
atcaaatcca gcagggatca agctttggct gaacgttgtc ttgctgcact aaccgaatgt  1620
gctgctagcg gagatggaaa tatcctggct cttgcagtgg atgcatctcg ggcaagatgt  1680
acagtgggag aaatcacaga tgccctgaaa aaggtatttg gtgaacataa agcgaatgat  1740
cgaatggtga gtggagcata tcgccaggaa tttggagaaa gtaaagagat aacatctgct  1800
atcaagaggg ttcataaatt catggaacgt gaaggtcgca gacctcgtct tcttgtagca  1860
aaaatgggac aagatggcca tgacagagga gcaaaagtta ttgctacagg atttgctgat  1920
cttggttttg atgtggacat aggccctctt ttccagactc ctcgtgaagt ggcccagcag  1980
gctgtggatg cggatgtgca tgctgtgggc ataagcaccc tcgctgctgg tcataaaacc  2040
ctagttcctg aactcatcaa agaacttaac tcccttggac ggccagatat tcttgtcatg  2100
tgtggagggg tgataccacc tcaggattat gaatttctgt ttgaagttgg tgtttccaat  2160
gtatttggtc ctgggactcg aattccaaag gctgccgttc aggtgcttga tgatattgag  2220
aagtgtttgg aaaagaagca gcaatctgta taa                               2253

<210>   3
<211>   750
<212>   PRT
<213>   Homo sapiens

<400>   3
Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      

Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          

Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              

Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  

Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  

Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      

Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         

Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             

Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 

Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 

Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     

Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         

Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             

Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 

Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 

Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     

Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         

Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             

Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 

Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 

Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     

Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         

Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             

Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 

Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 

Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     

Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         

Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             

Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 

Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 

Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     

Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         

Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             

Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 

Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 

Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     

Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         

Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             

Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 

Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 

Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     

Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser 
            660                 665                 670         

Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             

Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 

Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 

Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     

Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 

<210>   4
<211>   2253
<212>   RNA
<213>   Synthetic polynucleotide

<400>   4
augcuuaggg caaagaauca acucuuucug cugagcccac acuauuugcg ccaggugaaa  60
gagagcuccg gcucaaggcu gauccagcag cgucuuuugc aucagcagca gccacugcac  120
ccggaauggg ccgcucucgc gaagaagcag cugaagggaa agaacccgga agaucugauc  180
uggcacacuc cggagggaau cucaaucaag ccacuguacu cuaagagaga caccauggac  240
cuucccgaag aacugcccgg ggugaagccc uucacccggg gaccguaccc gaccauguac  300
accuuuagac cguggacgau ccgccaguac gcaggcuucu cgacggucga agaaagcaac  360
aaauucuaua aagacaacau uaaggccgga caacagggac uguccgucgc auucgaccuc  420
gccacccacc gcggauacga uucggacaau ccaaggguga gaggugacgu cggaauggcc  480
ggaguggcua uugauaccgu ggaggacacg aagauccugu ucgacggcau ccccuuggag  540
aagauguccg ugagcaugac uaugaauggc gcugugauuc cugugcucgc caacuucauc  600
gugaccggag aggaacaagg cgugccgaag gaaaagcuca cuggcacuau ccaaaacgac  660
auccucaaag aauucauggu ccgcaacacu uacauuuuuc cucccgaacc uucgaugaag  720
aucaucgccg auaucuuuga guacacggca aaacacaugc cgaaguucaa uucgaucucg  780
aucuccggau accauaugca agaggcuggg gccgacgcga uccucgaacu ggcuuacacc  840
cuggccgacg gacuggaaua cucacgcacu gggcugcagg ccggucugac caucgacgag  900
uucgcgccga gacuguccuu cuucuggggc auugguauga acuucuacau ggagaucgcc  960
aaaaugcgag caggccgcag gcucugggca caccucaucg agaaaauguu ccagccgaag  1020
aauucuaagu cgcuccugcu gcgcgcccac ugccagacua gcggauggag cuugacugaa  1080
caggacccgu acaacaauau cgugcggacu gccaucgaag cgauggccgc aguguucgga  1140
ggaacccagu cacugcauac caacagcuuu gacgaagccc ucggcuugcc aacugugaaa  1200
agcgcgcgga ucgcaaggaa cacucagauc auuauccaag aagaauccgg uaucccuaag  1260
guggccgauc cguggggcgg auccuacaug auggagugcc ugaccaauga cgucuacgau  1320
gccgcgcuga aacugaucaa cgagauugaa gagaugggag gaauggcuaa ggccguugca  1380
gaagggaucc cgaagcugcg gauugaggaa ugugcggccc ggcgccaggc ccgaaucgau  1440
agcggcucag aaguuaucgu gggugucaac aaguaccagc uugagaagga agaugcagug  1500
gagguccucg caauugauaa uaccuccguc cggaauagac aaaucgaaaa acugaaaaag  1560
aucaagagcu cccgcgacca agcccuggcg gaaagaugcu uggcggcccu gaccgagugc  1620
gcugccucag gcgacggaaa cauccuggca cucgcagucg augccucgcg ggcgcgcugc  1680
acugugggug agaucaccga cgcccucaag aaggucuuug gagagcauaa ggcgaacgac  1740
agaauggugu cgggagcaua ccggcaggag uucggcgaau ccaaagagau cacuucggcg  1800
aucaaacgcg ugcacaaguu cauggaacgg gaggggcggc ggccgcgccu ucucguggcg  1860
aagauggggc aggauggaca ugaccgcgga gcuaagguga ucgccaccgg guucgcugau  1920
cucggguucg acguggacau cggcccucug uuccaaaccc cuagagaagu ggcgcaacaa  1980
gcuguggaug cugaugugca ugcggucgga aucuccaccc ucgcagccgg acauaaaacu  2040
cuggugcccg agcucauaaa ggaacugaac ucgcugggcc ggccagauau ccuggucaug  2100
ugcgguggag ugaucccacc ucaagauuac gaguuccugu uugaagucgg agugucaaac  2160
guguuuggac cgggaacucg caucccaaag gcggccgugc aaguccuuga ugacauugaa  2220
aagugucugg agaaaaagca gcagagcgug uag                               2253

<210>   5
<211>   2253
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic polynucleotide

<400>   5
augcugcggg ccaagaacca gcuguuccuc cuuucccccc acuaccugag acaagucaaa  60
gaauccuccg gaucaagauu gauucagcaa cgccuguugc aucagcaaca gccauugcac  120
ccugaauggg ccgcccuggc uaagaagcag cuuaagggaa agaacccgga agaucugauc  180
uggcacaccc cggaaggcau cucuaucaag ccucuguacu ccaagagaga caccauggau  240
cucccugagg aacugccggg agucaagccu uuuacccgcg guccguaccc uaccauguac  300
acguuccgcc cguggaccau caggcaguac gccggauuca gcacggugga agagagcaac  360
aaguucuaca aggacaacau aaaggccgga cagcagggac uguccguggc cuucgaccug  420
gccacccauc ggggcuauga cucggacaac ccucgcgugc gcggggaugu cggaauggcc  480
ggaguggcga uugacacugu cgaggacacu aagauccugu ucgauggcau uccccuggaa  540
aagauguccg ugagcaugac uaugaacggc gcagugaucc cagugcuggc uaacuucauc  600
gugacuggag aggagcaagg ggugcccaaa gagaagcuga cuggaacuau ccagaacgau  660
auucugaagg aguuuauggu ccggaacacu uacauuuucc cgcccgagcc cucgaugaag  720
aucaucgcgg acauuuucga guacaccgcc aagcauaugc cuaaguucaa cuccaucucg  780
aucuccggau accacaugca ggaagccgga gcggacgcga uccuugaacu ggcguacacu  840
cuggccgaug gccuggaaua cucccgcacg ggcuugcagg ccggucugac caucgacgaa  900
uuugccccgc gguuguccuu cuuuugggga aucggcauga auuucuacau ggaaaucgcc  960
aagaugagag cgggccggag acugugggcc caccugaucg agaagauguu ccagcccaag  1020
aacucgaaaa gccuccuccu gcgggcgcac ugccagaccu ccggaugguc ccugaccgag  1080
caggacccgu acaacaacau cguccgaacc gcuauugagg ccauggccgc cguguuuggg  1140
ggaacucagu cacuccauac uaauuccuuc gaugaagccc uggggcuucc uaccgucaag  1200
agcgcccgga ucgccaggaa uacccagauc aucauucaag aagagucagg caucccuaaa  1260
guggccgacc ccuggggggg aagcuacaug auggaauguu ugaccaacga cgucuacgac  1320
gccgcccuga agcucaucaa cgaaauugaa gaaaugggcg gcauggccaa ggccguggca  1380
gaggggaucc cuaagcugcg gauugaggaa ugcgccgcca gacgccaggc ccgaaucgac  1440
uccgguuccg aagucaucgu gggcgugaac aaguaccagc uggagaagga agaugccgug  1500
gaagugcugg ccauugauaa caccuccgug cgcaaccgcc agaucgaaaa gcugaaaaag  1560
auuaagucgu cgcgcgacca ggcacuggcg gagagaugcc uggcugcacu gaccgagugc  1620
gcggcgucug gggacggcaa uauccuggca cuggcugugg acgcgagccg ggcccgcugc  1680
acugugggag agaucacuga ugcccucaag aaaguguucg gagaacacaa ggccaacgac  1740
agaauggugu cgggggccua ucgccaagaa uucggggagu cgaaggaaau caccagcgcc  1800
auuaagcggg ugcacaaguu cauggaaagg gaaggacgcc ggccacgccu ccugguggca  1860
aagaugggac aggacgguca cgacaggggc gcaaagguca ucgcgaccgg auucgccgac  1920
cucggcuucg auguggacau uggaccccuu uuccaaaccc cucgggaggu cgcccaacaa  1980
gcuguggaug ccgacgugca ugcuguggga auuucgaccc uggccgccgg ucacaagacc  2040
cuggugcccg aacugauuaa ggagcugaac ucacugggaa ggccugauau ucucgugaug  2100
uguggcggag ugaucccgcc gcaagacuac gaauuccugu ucgaagucgg cguguccaac  2160
guguucgggc ccggcacacg gaucccgaaa gccgcggucc aagugcucga ugauauugag  2220
aagugucucg aaaagaaaca gcaguccguc uag                               2253

<210>   6
<211>   140
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic polynucleotide

<400>   6
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac  60
cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu  120
gacucaccgu ccuugacacg                                              140

<210>   7
<211>   105
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic polynucleotide

<400>   7
cggguggcau cccugugacc ccuccccagu gccucuccug gcccuggaag uugccacucc  60
agugcccacc agccuugucc uaauaaaauu aaguugcauc aagcu                  105

<210>   8
<211>   105
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic polynucleotide

<400>   8
ggguggcauc ccugugaccc cuccccagug ccucuccugg cccuggaagu ugccacucca  60
gugcccacca gccuuguccu aauaaaauua aguugcauca aagcu                  105

<210>   9
<211>   800
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic polynucleotide

<220>
<221>   misc_feature
<222>   (1)..(800)
<223>   This sequence may include 300-800 nucleotides. See specification as filed for detailed description of possbile embodiments

<400>   9
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  60
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  120
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  180
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  240
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  300
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  360
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  420
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  480
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  540
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  600
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  660
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  720
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  780
aaaaaaaaaa aaaaaaaaaa                                              800

<210>   10
<211>   300
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic polynucleotide

<220>
<221>   
<222>   
<223>   

<400>   10
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  60
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  120
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  180
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  240
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  300

<210>   11
<211>   200
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic polynucleotide

<220>
<221>   misc_feature
<222>   (1)..(200)
<223>   This sequence may include 10-200 nucleotides. See specification as filed for detailed description of possbile embodiments

<400>   11
cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc  60
cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc  120
cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc  180
cccccccccc cccccccccc                                              200

<210>   12
<211>   2253
<212>   RNA
<213>   Synthetic polynucleotide

<400>   12
augcugcggg ccaagaacca gcuguuccug cugagcccuc acuaccugcg gcaggugaag  60
gagagcagcg gcagccggcu gauccagcag cggcugcugc accagcagca gccccugcac  120
cccgaguggg ccgcccuggc caagaagcag cugaagggca agaaccccga ggaccugauc  180
uggcacacgc ccgagggcau cagcaucaag ccccuguaca gcaagcggga caccauggac  240
cugcccgagg agcugcccgg cgugaagccc uucacccggg gccccuaccc caccauguac  300
accuuccggc ccuggaccau ccggcaguac gccggcuuca gcaccgugga ggagagcaac  360
aaguucuaca aggacaacau caaggccggc cagcagggcc ugagcguggc cuucgaccug  420
gccacccacc ggggcuacga cagcgacaac ccacgggugc ggggcgacgu gggcauggcc  480
ggcguggcca ucgacaccgu ggaggacacc aagauccugu ucgacggcau cccucuggag  540
aagaugagcg ugagcaugac caugaacggc gccgugaucc ccgugcuggc caacuucauc  600
gugaccggcg aggagcaggg cgugcccaag gagaagcuga ccggcaccau ccagaacgac  660
auccugaagg aguucauggu gcggaacacc uacaucuucc cucccgagcc cagcaugaag  720
aucaucgccg acaucuucga guacaccgcc aagcacaugc ccaaguucaa cagcaucagc  780
aucagcggcu accacaugca ggaggccggc gccgacgcca uccuggagcu ggccuacacc  840
cuggccgacg gccuggagua cagccggacc ggccugcagg ccggccugac caucgacgag  900
uucgcgcccc ggcugagcuu cuucuggggc aucggcauga acuucuacau ggagaucgcc  960
aagaugcggg ccggccggcg gcugugggcc caccugaucg agaagauguu ccagcccaag  1020
aacagcaaga gccugcugcu gcgggcccac ugccagacca gcggcuggag ccugaccgag  1080
caggaccccu acaacaacau cgugcggacc gccaucgagg ccauggccgc cguguucggc  1140
ggcacccaga gccugcacac caacagcuuc gacgaggccc ugggccugcc caccgugaag  1200
agcgcccgga ucgcccggaa cacccagauc aucauccagg aggagagcgg cauccccaag  1260
guggccgacc ccuggggcgg cagcuacaug auggagugcc ugaccaacga cguguacgac  1320
gccgcccuga agcugaucaa cgagaucgag gagaugggcg gcauggccaa ggccguggcc  1380
gagggcaucc ccaagcugcg gaucgaggag ugcgccgccc ggcggcaggc ccggaucgac  1440
agcggcagcg aggugaucgu gggcgugaac aaguaccagc uggagaagga ggacgccgug  1500
gaggugcugg ccaucgacaa caccagcgug cggaaccggc agaucgagaa gcugaagaag  1560
aucaagagca gccgggacca ggcccuggcc gagcggugcc uggccgcccu gaccgagugc  1620
gccgccagcg gcgacggcaa cauccuggcc cuggccgugg acgccagccg ggcccggugc  1680
accgugggcg agaucaccga cgcccugaag aagguguucg gcgagcacaa ggccaacgac  1740
cggaugguga gcggcgccua ccggcaggag uucggcgaga gcaaggagau caccagcgcc  1800
aucaagcggg ugcacaaguu cauggagcgg gagggccggc ggccccggcu gcugguggcc  1860
aagaugggcc aggacggcca cgaccggggc gccaagguga ucgccaccgg cuucgccgac  1920
cugggcuucg acguggacau cggcccacug uuccagacgc cccgggaggu ggcccagcag  1980
gccguggacg ccgacgugca cgccgugggc gugagcaccc uggccgccgg ccacaagacc  2040
cuggugcccg agcugaucaa ggagcugaac agccugggcc ggcccgacau ccuggugaug  2100
ugcggcggcg ugaucccgcc ccaggacuac gaguuccugu ucgagguggg cgugagcaac  2160
guguucggcc ccggcacccg gauccccaag gccgccgugc aggugcugga cgacaucgag  2220
aagugccugg agaagaagca gcagagcgug uga                               2253

