                         SEQUENCE LISTING

<110>  GUARDIAN THERAPEUTICS, LLC
 
<120>  RNA POLYMERASE FOR SYNTHESIS OF MODIFIED RNA

<130>  2125.1000PCT

<140>  PCT/US2019/050777
<141>  2019-09-12

<150>  62/730,226
<151>  2018-09-12

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  883
<212>  PRT
<213>  Bacteriophage T7

<400>  1

Met Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu 
1               5                   10                  15      


Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 
            20                  25                  30          


Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 
        35                  40                  45              


Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 
    50                  55                  60                  


Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys 
65                  70                  75                  80  


Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 
                85                  90                  95      


Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu 
            100                 105                 110         


Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu Thr Ser 
        115                 120                 125             


Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 
    130                 135                 140                 


Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys 
145                 150                 155                 160 


His Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 
                165                 170                 175     


Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 
            180                 185                 190         


Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 
        195                 200                 205             


Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 
    210                 215                 220                 


Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln Asp 
225                 230                 235                 240 


Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu Ala Ile Ala Thr 
                245                 250                 255     


Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 
            260                 265                 270         


Val Pro Pro Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 
        275                 280                 285             


Asn Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 
    290                 295                 300                 


Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile 
305                 310                 315                 320 


Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 
                325                 330                 335     


Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile 
            340                 345                 350         


Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp Ile Asp 
        355                 360                 365             


Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 
    370                 375                 380                 


Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe 
385                 390                 395                 400 


Met Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 
                405                 410                 415     


Pro Tyr Asn Met Asp Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 
            420                 425                 430         


Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 
        435                 440                 445             


Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 
    450                 455                 460                 


Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile Lys 
465                 470                 475                 480 


Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys Ala Lys Ser Pro 
                485                 490                 495     


Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 
            500                 505                 510         


Ala Phe Cys Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 
        515                 520                 525             


Asn Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 
    530                 535                 540                 


His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn 
545                 550                 555                 560 


Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 
                565                 570                 575     


Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn 
            580                 585                 590         


Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser Glu Lys 
        595                 600                 605             


Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 
    610                 615                 620                 


Val Thr Arg Ser Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly 
625                 630                 635                 640 


Ser Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 
                645                 650                 655     


Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 
            660                 665                 670         


Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 
        675                 680                 685             


Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 
    690                 695                 700                 


Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu Arg 
705                 710                 715                 720 


Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly Phe Pro Val Trp 
                725                 730                 735     


Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 
            740                 745                 750         


Gly Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 
        755                 760                 765             


Ile Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 
    770                 775                 780                 


Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu 
785                 790                 795                 800 


Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 
                805                 810                 815     


Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met 
            820                 825                 830         


Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr Asp Gln 
        835                 840                 845             


Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 
    850                 855                 860                 


Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe 
865                 870                 875                 880 


Ala Phe Ala 
            


<210>  2
<211>  883
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  2

Met Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu 
1               5                   10                  15      


Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 
            20                  25                  30          


Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 
        35                  40                  45              


Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 
    50                  55                  60                  


Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys 
65                  70                  75                  80  


Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 
                85                  90                  95      


Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu 
            100                 105                 110         


Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu Thr Ser 
        115                 120                 125             


Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 
    130                 135                 140                 


Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys 
145                 150                 155                 160 


His Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 
                165                 170                 175     


Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 
            180                 185                 190         


Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 
        195                 200                 205             


Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 
    210                 215                 220                 


Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln Asp 
225                 230                 235                 240 


Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu Ala Ile Ala Thr 
                245                 250                 255     


Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 
            260                 265                 270         


Val Pro Pro Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 
        275                 280                 285             


Asn Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 
    290                 295                 300                 


Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile 
305                 310                 315                 320 


Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 
                325                 330                 335     


Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile 
            340                 345                 350         


Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp Ile Asp 
        355                 360                 365             


Met Asn Pro Glu Ala Leu Thr Ala Trp Arg Arg Ala Ala Ala Ala Val 
    370                 375                 380                 


Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe 
385                 390                 395                 400 


Met Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 
                405                 410                 415     


Pro Tyr Asn Met Asp Trp Arg Gly Arg Val Tyr Ala Val Pro Met Phe 
            420                 425                 430         


Thr Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 
        435                 440                 445             


Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 
    450                 455                 460                 


Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile Lys 
465                 470                 475                 480 


Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys Ala Lys Ser Pro 
                485                 490                 495     


Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 
            500                 505                 510         


Ala Phe Cys Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 
        515                 520                 525             


Asn Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 
    530                 535                 540                 


His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn 
545                 550                 555                 560 


Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 
                565                 570                 575     


Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn 
            580                 585                 590         


Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser Glu Lys 
        595                 600                 605             


Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 
    610                 615                 620                 


Val Thr Arg Ser Val Thr Lys Arg Pro Val Met Thr Leu Ala Leu Gly 
625                 630                 635                 640 


Ser Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 
                645                 650                 655     


Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 
            660                 665                 670         


Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 
        675                 680                 685             


Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 
    690                 695                 700                 


Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu Arg 
705                 710                 715                 720 


Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly Phe Pro Val Trp 
                725                 730                 735     


Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 
            740                 745                 750         


Gly Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 
        755                 760                 765             


Ile Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val Ala 
    770                 775                 780                 


Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu 
785                 790                 795                 800 


Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 
                805                 810                 815     


Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met 
            820                 825                 830         


Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr Asp Gln 
        835                 840                 845             


Ile Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 
    850                 855                 860                 


Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Tyr 
865                 870                 875                 880 


Ala Phe Ala 
            


<210>  3
<211>  2652
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  3
atgaacacaa taaacatagc taagaacgac tttagcgaca tcgaactggc ggcgattccg       60

tttaacaccc tggcggacca ctatggcgag cgtctggcgc gtgaacagct ggcgctggag      120

cacgaaagct atgagatggg tgaagcgcgt ttccgtaaga tgtttgagcg tcaactgaaa      180

gcgggcgaag ttgcggacaa cgcggcggcg aagccgctga ttaccaccct gctgccgaaa      240

atgatcgcgc gtattaacga ttggttcgag gaagttaagg cgaaacgtgg caagcgtccg      300

accgcgttcc agtttctgca agagatcaag ccggaagcgg tggcgtacat caccattaaa      360

accaccctgg cgtgcctgac cagcgcggac aacaccaccg ttcaagcggt tgcgagcgcg      420

attggtcgtg cgattgagga cgaagcgcgt tttggccgta ttcgtgatct ggaggcgaag      480

cacttcaaga aaaacgttga ggaacagctg aacaaacgtg tgggtcacgt ttataagaaa      540

gcgtttatgc aagtggttga agcggacatg ctgagcaaag gcctgctggg tggcgaggcg      600

tggagcagct ggcacaaaga agatagcatc cacgtgggtg ttcgttgcat cgagatgctg      660

attgaaagca ccggcatggt gagcctgcac cgtcagaacg cgggcgtggt tggtcaagac      720

agcgaaacca tcgaactggc gccggagtac gcggaagcga tcgcgacccg tgcgggcgcg      780

ctggcgggta tcagcccgat gttccagccg tgcgtggttc cgccgaaacc gtggaccggt      840

attaccggtg gcggttactg ggcgaacggt cgtcgtccgc tggcgctggt gcgtacccac      900

agcaagaaag cgctgatgcg ttacgaggat gtttatatgc cggaagtgta taaggcgatc      960

aacattgcgc aaaacaccgc gtggaaaatt aacaagaaag tgctggcggt tgcgaacgtg     1020

atcaccaagt ggaaacactg cccggttgag gacatcccgg cgattgaacg tgaggaactg     1080

ccgatgaagc cggaggacat cgatatgaac ccggaagcgc tgaccgcgtg gcgtcgtgcg     1140

gcggcggcgg tgtaccgtaa ggataaagcg cgcaaaagcc gtcgtattag cctggagttc     1200

atgctggaac aggcgaacaa gtttgcgaac cacaaagcga tctggttccc gtacaacatg     1260

gactggcgtg gtcgtgttta tgcggtgcca atgttcaccc cgcaaggcaa cgatatgacc     1320

aagggtctgc tgaccctggc gaagggcaaa ccgattggca aagagggtta ctattggctg     1380

aaaatccacg gcgcgaactg cgcgggtgtt gacaaggtgc cgttcccgga gcgtatcaag     1440

ttcatcgagg aaaaccacga aaacatcatg gcgtgcgcga aaagcccgct ggagaacacc     1500

tggtgggcgg aacaggatag cccgttctgc tttctggcgt tctgctttga atacgcgggc     1560

gttcaacacc acggtctgag ctataactgc agcctgccgc tggcgtttga tggcagctgc     1620

agcggtatcc agcacttcag cgcgatgctg cgtgatgagg ttggcggtcg cgcggtgaac     1680

ctgctgccga gcgaaaccgt gcaggacatc tacggtattg ttgcgaagaa agtgaacgag     1740

atcctgcaag cggacgcgat taacggtacc gataacgagg tggttaccgt taccgatgaa     1800

aacaccggcg agatcagcga aaaggtgaaa ctgggtacca aggcgctggc gggccagtgg     1860

ctggcgtatg gcgttacccg tagcgtgacc aagcgtccag ttatgaccct ggcgctgggc     1920

agcaaagagt tcggttttcg tcagcaagtg ctggaagaca ccatccaacc ggcgattgat     1980

agcggcaagg gtctgatgtt tacccagccg aaccaagcgg cgggttacat ggcgaaactg     2040

atctgggaga gcgtgagcgt taccgtggtt gcggcggttg aagcgatgaa ctggctgaag     2100

agcgcggcga aactgctggc ggcggaagtg aaggacaaga aaaccggtga aattctgcgt     2160

aaacgttgcg cggttcactg ggtgaccccg gatggcttcc cggtttggca ggagtataag     2220

aaaccgatcc aaacccgtct gaacctgatg ttcctgggcc agtttcgtct gcaaccgacc     2280

atcaacacca acaaggacag cgagattgat gcgcacaaac aggaaagcgg tattgcgccg     2340

aactttgtgg cgagccaaga cggcagccac ctgcgtaaga ccgtggtttg ggcgcacgag     2400

aaatacggta tcgagagctt cgcgctgatt cacgacagct ttggtaccat cccggcggat     2460

gcggcgaacc tgttcaaggc ggttcgtgaa accatggtgg acacctacga aagctgcgat     2520

gttctggcgg acttctatga tcagatcgcg gaccaactgc acgaaagcca gctggataaa     2580

atgccggcgc tgccggcgaa gggtaacctg aacctgcgtg acattctgga gagcgattat     2640

gcgtttgcgt aa                                                         2652


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  4

Met His His His His His His Gly Ser 
1               5                   


<210>  5
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  5

Met His His His His His His Gly Ser Met Asn Thr Ile Asn Ile Ala 
1               5                   10                  15      


Lys Asn Asp Phe Ser Asp Ile Glu Leu Ala Ala Ile Pro Phe Asn Thr 
            20                  25                  30          


Leu Ala Asp His Tyr Gly Glu Arg Leu Ala Arg Glu Gln Leu Ala Leu 
        35                  40                  45              


Glu His Glu Ser Tyr Glu Met Gly Glu Ala Arg Phe Arg Lys Met Phe 
    50                  55                  60                  


Glu Arg Gln Leu Lys Ala Gly Glu Val Ala Asp Asn Ala Ala Ala Lys 
65                  70                  75                  80  


Pro Leu Ile Thr Thr Leu Leu Pro Lys Met Ile Ala Arg Ile Asn Asp 
                85                  90                  95      


Trp Phe Glu Glu Val Lys Ala Lys Arg Gly Lys Arg Pro Thr Ala Phe 
            100                 105                 110         


Gln Phe Leu Gln Glu Ile Lys Pro Glu Ala Val Ala Tyr Ile Thr Ile 
        115                 120                 125             


Lys Thr Thr Leu Ala Cys Leu Thr Ser Ala Asp Asn Thr Thr Val Gln 
    130                 135                 140                 


Ala Val Ala Ser Ala Ile Gly Arg Ala Ile Glu Asp Glu Ala Arg Phe 
145                 150                 155                 160 


Gly Arg Ile Arg Asp Leu Glu Ala Lys His Phe Lys Lys Asn Val Glu 
                165                 170                 175     


Glu Gln Leu Asn Lys Arg Val Gly His Val Tyr Lys Lys Ala Phe Met 
            180                 185                 190         


Gln Val Val Glu Ala Asp Met Leu Ser Lys Gly Leu Leu Gly Gly Glu 
        195                 200                 205             


Ala Trp Ser Ser Trp His Lys Glu Asp Ser Ile His Val Gly Val Arg 
    210                 215                 220                 


Cys Ile Glu Met Leu Ile Glu Ser Thr Gly Met Val Ser Leu His Arg 
225                 230                 235                 240 


Gln Asn Ala Gly Val Val Gly Gln Asp Ser Glu Thr Ile Glu Leu Ala 
                245                 250                 255     


Pro Glu Tyr Ala Glu Ala Ile Ala Thr Arg Ala Gly Ala Leu Ala Gly 
            260                 265                 270         


Ile Ser Pro Met Phe Gln Pro Cys Val Val Pro Pro Lys Pro Trp Thr 
        275                 280                 285             


Gly Ile Thr Gly Gly Gly Tyr Trp Ala Asn Gly Arg Arg Pro Leu Ala 
    290                 295                 300                 


Leu Val Arg Thr His Ser Lys Lys Ala Leu Met Arg Tyr Glu Asp Val 
305                 310                 315                 320 


Tyr Met Pro Glu Val Tyr Lys Ala Ile Asn Ile Ala Gln Asn Thr Ala 
                325                 330                 335     


Trp Lys Ile Asn Lys Lys Val Leu Ala Val Ala Asn Val Ile Thr Lys 
            340                 345                 350         


Trp Lys His Cys Pro Val Glu Asp Ile Pro Ala Ile Glu Arg Glu Glu 
        355                 360                 365             


Leu Pro Met Lys Pro Glu Asp Ile Asp Met Asn Pro Glu Ala Leu Thr 
    370                 375                 380                 


Ala Trp Arg Arg Ala Ala Ala Ala Val Tyr Arg Lys Asp Lys Ala Arg 
385                 390                 395                 400 


Lys Ser Arg Arg Ile Ser Leu Glu Phe Met Leu Glu Gln Ala Asn Lys 
                405                 410                 415     


Phe Ala Asn His Lys Ala Ile Trp Phe Pro Tyr Asn Met Asp Trp Arg 
            420                 425                 430         


Gly Arg Val Tyr Ala Val Pro Met Phe Thr Pro Gln Gly Asn Asp Met 
        435                 440                 445             


Thr Lys Gly Leu Leu Thr Leu Ala Lys Gly Lys Pro Ile Gly Lys Glu 
    450                 455                 460                 


Gly Tyr Tyr Trp Leu Lys Ile His Gly Ala Asn Cys Ala Gly Val Asp 
465                 470                 475                 480 


Lys Val Pro Phe Pro Glu Arg Ile Lys Phe Ile Glu Glu Asn His Glu 
                485                 490                 495     


Asn Ile Met Ala Cys Ala Lys Ser Pro Leu Glu Asn Thr Trp Trp Ala 
            500                 505                 510         


Glu Gln Asp Ser Pro Phe Cys Phe Leu Ala Phe Cys Phe Glu Tyr Ala 
        515                 520                 525             


Gly Val Gln His His Gly Leu Ser Tyr Asn Cys Ser Leu Pro Leu Ala 
    530                 535                 540                 


Phe Asp Gly Ser Cys Ser Gly Ile Gln His Phe Ser Ala Met Leu Arg 
545                 550                 555                 560 


Asp Glu Val Gly Gly Arg Ala Val Asn Leu Leu Pro Ser Glu Thr Val 
                565                 570                 575     


Gln Asp Ile Tyr Gly Ile Val Ala Lys Lys Val Asn Glu Ile Leu Gln 
            580                 585                 590         


Ala Asp Ala Ile Asn Gly Thr Asp Asn Glu Val Val Thr Val Thr Asp 
        595                 600                 605             


Glu Asn Thr Gly Glu Ile Ser Glu Lys Val Lys Leu Gly Thr Lys Ala 
    610                 615                 620                 


Leu Ala Gly Gln Trp Leu Ala Tyr Gly Val Thr Arg Ser Val Thr Lys 
625                 630                 635                 640 


Arg Pro Val Met Thr Leu Ala Leu Gly Ser Lys Glu Phe Gly Phe Arg 
                645                 650                 655     


Gln Gln Val Leu Glu Asp Thr Ile Gln Pro Ala Ile Asp Ser Gly Lys 
            660                 665                 670         


Gly Leu Met Phe Thr Gln Pro Asn Gln Ala Ala Gly Tyr Met Ala Lys 
        675                 680                 685             


Leu Ile Trp Glu Ser Val Ser Val Thr Val Val Ala Ala Val Glu Ala 
    690                 695                 700                 


Met Asn Trp Leu Lys Ser Ala Ala Lys Leu Leu Ala Ala Glu Val Lys 
705                 710                 715                 720 


Asp Lys Lys Thr Gly Glu Ile Leu Arg Lys Arg Cys Ala Val His Trp 
                725                 730                 735     


Val Thr Pro Asp Gly Phe Pro Val Trp Gln Glu Tyr Lys Lys Pro Ile 
            740                 745                 750         


Gln Thr Arg Leu Asn Leu Met Phe Leu Gly Gln Phe Arg Leu Gln Pro 
        755                 760                 765             


Thr Ile Asn Thr Asn Lys Asp Ser Glu Ile Asp Ala His Lys Gln Glu 
    770                 775                 780                 


Ser Gly Ile Ala Pro Asn Phe Val Ala Ser Gln Asp Gly Ser His Leu 
785                 790                 795                 800 


Arg Lys Thr Val Val Trp Ala His Glu Lys Tyr Gly Ile Glu Ser Phe 
                805                 810                 815     


Ala Leu Ile His Asp Ser Phe Gly Thr Ile Pro Ala Asp Ala Ala Asn 
            820                 825                 830         


Leu Phe Lys Ala Val Arg Glu Thr Met Val Asp Thr Tyr Glu Ser Cys 
        835                 840                 845             


Asp Val Leu Ala Asp Phe Tyr Asp Gln Ile Ala Asp Gln Leu His Glu 
    850                 855                 860                 


Ser Gln Leu Asp Lys Met Pro Ala Leu Pro Ala Lys Gly Asn Leu Asn 
865                 870                 875                 880 


Leu Arg Asp Ile Leu Glu Ser Asp Tyr Ala Phe Ala 
                885                 890         


<210>  6
<211>  2679
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  6
atgcatcacc accaccacca cggatcaatg aacacaataa acatagctaa gaacgacttt       60

agcgacatcg aactggcggc gattccgttt aacaccctgg cggaccacta tggcgagcgt      120

ctggcgcgtg aacagctggc gctggagcac gaaagctatg agatgggtga agcgcgtttc      180

cgtaagatgt ttgagcgtca actgaaagcg ggcgaagttg cggacaacgc ggcggcgaag      240

ccgctgatta ccaccctgct gccgaaaatg atcgcgcgta ttaacgattg gttcgaggaa      300

gttaaggcga aacgtggcaa gcgtccgacc gcgttccagt ttctgcaaga gatcaagccg      360

gaagcggtgg cgtacatcac cattaaaacc accctggcgt gcctgaccag cgcggacaac      420

accaccgttc aagcggttgc gagcgcgatt ggtcgtgcga ttgaggacga agcgcgtttt      480

ggccgtattc gtgatctgga ggcgaagcac ttcaagaaaa acgttgagga acagctgaac      540

aaacgtgtgg gtcacgttta taagaaagcg tttatgcaag tggttgaagc ggacatgctg      600

agcaaaggcc tgctgggtgg cgaggcgtgg agcagctggc acaaagaaga tagcatccac      660

gtgggtgttc gttgcatcga gatgctgatt gaaagcaccg gcatggtgag cctgcaccgt      720

cagaacgcgg gcgtggttgg tcaagacagc gaaaccatcg aactggcgcc ggagtacgcg      780

gaagcgatcg cgacccgtgc gggcgcgctg gcgggtatca gcccgatgtt ccagccgtgc      840

gtggttccgc cgaaaccgtg gaccggtatt accggtggcg gttactgggc gaacggtcgt      900

cgtccgctgg cgctggtgcg tacccacagc aagaaagcgc tgatgcgtta cgaggatgtt      960

tatatgccgg aagtgtataa ggcgatcaac attgcgcaaa acaccgcgtg gaaaattaac     1020

aagaaagtgc tggcggttgc gaacgtgatc accaagtgga aacactgccc ggttgaggac     1080

atcccggcga ttgaacgtga ggaactgccg atgaagccgg aggacatcga tatgaacccg     1140

gaagcgctga ccgcgtggcg tcgtgcggcg gcggcggtgt accgtaagga taaagcgcgc     1200

aaaagccgtc gtattagcct ggagttcatg ctggaacagg cgaacaagtt tgcgaaccac     1260

aaagcgatct ggttcccgta caacatggac tggcgtggtc gtgtttatgc ggtgccaatg     1320

ttcaccccgc aaggcaacga tatgaccaag ggtctgctga ccctggcgaa gggcaaaccg     1380

attggcaaag agggttacta ttggctgaaa atccacggcg cgaactgcgc gggtgttgac     1440

aaggtgccgt tcccggagcg tatcaagttc atcgaggaaa accacgaaaa catcatggcg     1500

tgcgcgaaaa gcccgctgga gaacacctgg tgggcggaac aggatagccc gttctgcttt     1560

ctggcgttct gctttgaata cgcgggcgtt caacaccacg gtctgagcta taactgcagc     1620

ctgccgctgg cgtttgatgg cagctgcagc ggtatccagc acttcagcgc gatgctgcgt     1680

gatgaggttg gcggtcgcgc ggtgaacctg ctgccgagcg aaaccgtgca ggacatctac     1740

ggtattgttg cgaagaaagt gaacgagatc ctgcaagcgg acgcgattaa cggtaccgat     1800

aacgaggtgg ttaccgttac cgatgaaaac accggcgaga tcagcgaaaa ggtgaaactg     1860

ggtaccaagg cgctggcggg ccagtggctg gcgtatggcg ttacccgtag cgtgaccaag     1920

cgtccagtta tgaccctggc gctgggcagc aaagagttcg gttttcgtca gcaagtgctg     1980

gaagacacca tccaaccggc gattgatagc ggcaagggtc tgatgtttac ccagccgaac     2040

caagcggcgg gttacatggc gaaactgatc tgggagagcg tgagcgttac cgtggttgcg     2100

gcggttgaag cgatgaactg gctgaagagc gcggcgaaac tgctggcggc ggaagtgaag     2160

gacaagaaaa ccggtgaaat tctgcgtaaa cgttgcgcgg ttcactgggt gaccccggat     2220

ggcttcccgg tttggcagga gtataagaaa ccgatccaaa cccgtctgaa cctgatgttc     2280

ctgggccagt ttcgtctgca accgaccatc aacaccaaca aggacagcga gattgatgcg     2340

cacaaacagg aaagcggtat tgcgccgaac tttgtggcga gccaagacgg cagccacctg     2400

cgtaagaccg tggtttgggc gcacgagaaa tacggtatcg agagcttcgc gctgattcac     2460

gacagctttg gtaccatccc ggcggatgcg gcgaacctgt tcaaggcggt tcgtgaaacc     2520

atggtggaca cctacgaaag ctgcgatgtt ctggcggact tctatgatca gatcgcggac     2580

caactgcacg aaagccagct ggataaaatg ccggcgctgc cggcgaaggg taacctgaac     2640

ctgcgtgaca ttctggagag cgattatgcg tttgcgtaa                            2679


<210>  7
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (23)..(52)
<223>  n is a, c, t, or g

<400>  7
ggggagtaca ataacgttct cgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnggatcgtt       60

acgactagca tcgatg                                                       76


<210>  8
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  8
taatacgact cactatgggg agtacaataa cgttctcg                               38


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  9
catcgatgct agtcgtaacg atcc                                              24


<210>  10
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (23)..(52)
<223>  n is a, c, t, or g

<400>  10
gggagagcat tgctcgttag tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnagctagtg       60

actcggatca tctagg                                                       76


<210>  11
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  11
taatacgact cactataggg agagcattgc tcgttagtg                              39


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  12
cctagatgat ccgagtcact agct                                              24


<210>  13
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   Description of Artificial Sequence: Synthetic polynucleotide

<400>  13
acactctttc cctacacgac gctcttccga tctactgatc gaagtacgta tggagctctc       60

gtctaatacg actcactata ggg                                               83


<210>  14
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  14
gactggagtt cagacgtgtg ctcttccgat cttagcatga cggatcggta cgtcagtatc       60

gacctagatg atccgagtca ct                                                82


<210>  15
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  15
tcgtctcgga gtttatctcc gtggtcgttg a                                      31


<210>  16
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  16
gggagagcat tgctcgttag tgtcgtctcg gagtttatct ccgtggtcgt tgaagctagt       60

gactcggatc atctagg                                                      77


<210>  17
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  17
tcgtcttggt aattcccttt ctggtcgttt a                                      31


<210>  18
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  18
gggagagcat tgctcgttag tgtcgtcttg gtaattccct ttctggtcgt ttaagctagt       60

gactcggatc atctagg                                                      77


<210>  19
<211>  31
<212>  DNA
<213>  Artificial Sequencce

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  19
tcgtcttaaa cttcgtgttt ttggtcgttg t                                      31


<210>  20
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  20
gggagagcat tgctcgttag tgtcgtctta aacttcgtgt ttttggtcgt tgtagctagt       60

gactcggatc atctagg                                                      77


<210>  21
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  21
tcgtcttcaa tcatgcattg ttggtcgttg a                                      31


<210>  22
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polynucleotide

<400>  22
gggagagcat tgctcgttag tgtcgtcttc aatcatgcat tgttggtcgt tgaagctagt       60

gactcggatc atctagg                                                      77


<210>  23
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  23
tcgtctcgcg aacgttaatc gcgtggtcgt g                                      31


<210>  24
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  24
gggagagcat tgctcgttag tgtcgtctcg cgaacgttaa tcgcgtggtc gtgagctagt       60

gactcggatc atctagg                                                      77


<210>  25
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  25
tcgtctcgaa tcgaactttc gtggtcgtta a                                      31


<210>  26
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  26
gggagagcat tgctcgttag tgtcgtctcg aatcgaactt tcgtggtcgt taaagctagt       60

gactcggatc atctagg                                                      77


<210>  27
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  27
tcgtcttgac ctttgctggt catggtcgta a                                      31


<210>  28
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  28
gggagagcat tgctcgttag tgtcgtcttg acctttgctg gtcatggtcg taaagctagt       60

gactcggatc atctagg                                                      77


<210>  29
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  29
tcgtctaatc ggttttccgg tttggtcgtt g                                      31


<210>  30
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  30
gggagagcat tgctcgttag tgtcgtctaa tcggttttcc ggtttggtcg ttgagctagt       60

gactcggatc atctagg                                                      77


<210>  31
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  31
tcgtctcggg atttttcccg tggtcgttca t                                      31


<210>  32
<211>  77
<212>  DNA
<213>  Artificial Seqeunce

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  32
gggagagcat tgctcgttag tgtcgtctcg ggatttttcc cgtggtcgtt catagctagt       60

gactcggatc atctagg                                                      77


<210>  33
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  33
tcgtctcgag ttgtgattac tcgtggtcgt a                                      31


<210>  34
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  34
gggagagcat tgctcgttag tgtcgtctcg agttgtgatt actcgtggtc gtaagctagt       60

gactcggatc atctagg                                                      77


<210>  35
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  35
tcgtctcatc gaatggtcgg tgtggtcgtt a                                      31


<210>  36
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  36
gggagagcat tgctcgttag tgtcgtctca tcgaatggtc ggtgtggtcg ttaagctagt       60

gactcggatc atctagg                                                      77


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  37
gggagagcat tgctcgttag tg                                                22


<210>  38
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  38
agctagtgac tcggatcatc tagg                                              24


<210>  39
<211>  6
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  39
tcgtct                                                                   6


<210>  40
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  40
tggtcgt                                                                  7


<210>  41
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  41
aacgauaugg ucccggaagu ugggccucgu u                                      31


<210>  42
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  42
gcaugaguga ccauauaggu ugccgcgcuc g                                      31


<210>  43
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  43
gacugcggug cguugaugcc guguguugcu c                                      31


<210>  44
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  44
gcguuacagc aguugccaca aggcacguuu u                                      31


<210>  45
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  45
gagccuaugg uuguugugug cuccucgcgg g                                      31


