                         SEQUENCE LISTING

<110>  Malcolm, Thomas
 
<120>  COMPOSITIONS AND METHODS FOR EXCISION WITH SINGLE gRNA

<130>  0400-110-PRV-PCT

<140>  PCT/US19/50507
<141>  2019-09-11

<150>  US 62/730,901
<151>  2018-09-13

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  949
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMAN 1

<400>  1

Met Arg Asp Ser Ile Thr Ala Pro Arg Tyr Ser Ser Ala Leu Ala Ala 
1               5                   10                  15      


Arg Ile Lys Glu Phe Asn Ser Ala Phe Lys Leu Gly Ile Asp Leu Gly 
            20                  25                  30          


Thr Lys Thr Gly Gly Val Ala Leu Val Lys Asp Asn Lys Val Leu Leu 
        35                  40                  45              


Ala Lys Thr Phe Leu Asp Tyr His Lys Gln Thr Leu Glu Glu Arg Arg 
    50                  55                  60                  


Ile His Arg Arg Asn Arg Arg Ser Arg Leu Ala Arg Arg Lys Arg Ile 
65                  70                  75                  80  


Ala Arg Leu Arg Ser Trp Ile Leu Arg Gln Lys Ile Tyr Gly Lys Gln 
                85                  90                  95      


Leu Pro Asp Pro Tyr Lys Ile Lys Lys Met Gln Leu Pro Asn Gly Val 
            100                 105                 110         


Arg Lys Gly Glu Asn Trp Ile Asp Leu Val Val Ser Gly Arg Asp Leu 
        115                 120                 125             


Ser Pro Glu Ala Phe Val Arg Ala Ile Thr Leu Ile Phe Gln Lys Arg 
    130                 135                 140                 


Gly Gln Arg Tyr Glu Glu Val Ala Lys Glu Ile Glu Glu Met Ser Tyr 
145                 150                 155                 160 


Lys Glu Phe Ser Thr His Ile Lys Ala Leu Thr Ser Val Thr Glu Glu 
                165                 170                 175     


Glu Phe Thr Ala Leu Ala Ala Glu Ile Glu Arg Arg Gln Asp Val Val 
            180                 185                 190         


Asp Thr Asp Lys Glu Ala Glu Arg Tyr Thr Gln Leu Ser Glu Leu Leu 
        195                 200                 205             


Ser Lys Val Ser Glu Ser Lys Ser Glu Ser Lys Asp Arg Ala Gln Arg 
    210                 215                 220                 


Lys Glu Asp Leu Gly Lys Val Val Asn Ala Phe Cys Ser Ala His Arg 
225                 230                 235                 240 


Ile Glu Asp Lys Asp Lys Trp Cys Lys Glu Leu Met Lys Leu Leu Asp 
                245                 250                 255     


Arg Pro Val Arg His Ala Arg Phe Leu Asn Lys Val Leu Ile Arg Cys 
            260                 265                 270         


Asn Ile Cys Asp Arg Ala Thr Pro Lys Lys Ser Arg Pro Asp Val Arg 
        275                 280                 285             


Glu Leu Leu Tyr Phe Asp Thr Val Arg Asn Phe Leu Lys Ala Gly Arg 
    290                 295                 300                 


Val Glu Gln Asn Pro Asp Val Ile Ser Tyr Tyr Lys Lys Ile Tyr Met 
305                 310                 315                 320 


Asp Ala Glu Val Ile Arg Val Lys Ile Leu Asn Lys Glu Lys Leu Thr 
                325                 330                 335     


Asp Glu Asp Lys Lys Gln Lys Arg Lys Leu Ala Ser Glu Leu Asn Arg 
            340                 345                 350         


Tyr Lys Asn Lys Glu Tyr Val Thr Asp Ala Gln Lys Lys Met Gln Glu 
        355                 360                 365             


Gln Leu Lys Thr Leu Leu Phe Met Lys Leu Thr Gly Arg Ser Arg Tyr 
    370                 375                 380                 


Cys Met Ala His Leu Lys Glu Arg Ala Ala Gly Lys Asp Val Glu Glu 
385                 390                 395                 400 


Gly Leu His Gly Val Val Gln Lys Arg His Asp Arg Asn Ile Ala Gln 
                405                 410                 415     


Arg Asn His Asp Leu Arg Val Ile Asn Leu Ile Glu Ser Leu Leu Phe 
            420                 425                 430         


Asp Gln Asn Lys Ser Leu Ser Asp Ala Ile Arg Lys Asn Gly Leu Met 
        435                 440                 445             


Tyr Val Thr Ile Glu Ala Pro Glu Pro Lys Thr Lys His Ala Lys Lys 
    450                 455                 460                 


Gly Ala Ala Val Val Arg Asp Pro Arg Lys Leu Lys Glu Lys Leu Phe 
465                 470                 475                 480 


Asp Asp Gln Asn Gly Val Cys Ile Tyr Thr Gly Leu Gln Leu Asp Lys 
                485                 490                 495     


Leu Glu Ile Ser Lys Tyr Glu Lys Asp His Ile Phe Pro Asp Ser Arg 
            500                 505                 510         


Asp Gly Pro Ser Ile Arg Asp Asn Leu Val Leu Thr Thr Lys Glu Ile 
        515                 520                 525             


Asn Ser Asp Lys Gly Asp Arg Thr Pro Trp Glu Trp Met His Asp Asn 
    530                 535                 540                 


Pro Glu Lys Trp Lys Ala Phe Glu Arg Arg Val Ala Glu Phe Tyr Lys 
545                 550                 555                 560 


Lys Gly Arg Ile Asn Glu Arg Lys Arg Glu Leu Leu Leu Asn Lys Gly 
                565                 570                 575     


Thr Glu Tyr Pro Gly Asp Asn Pro Thr Glu Leu Ala Arg Gly Gly Ala 
            580                 585                 590         


Arg Val Asn Asn Phe Ile Thr Glu Phe Asn Asp Arg Leu Lys Thr His 
        595                 600                 605             


Gly Val Gln Glu Leu Gln Thr Ile Phe Glu Arg Asn Lys Pro Ile Val 
    610                 615                 620                 


Gln Val Val Arg Gly Glu Glu Thr Gln Arg Leu Arg Arg Gln Trp Asn 
625                 630                 635                 640 


Ala Leu Asn Gln Asn Phe Ile Pro Leu Lys Asp Arg Ala Met Ser Phe 
                645                 650                 655     


Asn His Ala Glu Asp Ala Ala Ile Ala Ala Ser Met Pro Pro Lys Phe 
            660                 665                 670         


Trp Arg Glu Gln Ile Tyr Arg Thr Ala Trp His Phe Gly Pro Ser Gly 
        675                 680                 685             


Asn Glu Arg Pro Asp Phe Ala Leu Ala Glu Leu Ala Pro Gln Trp Asn 
    690                 695                 700                 


Asp Phe Phe Met Thr Lys Gly Gly Pro Ile Ile Ala Val Leu Gly Lys 
705                 710                 715                 720 


Thr Lys Tyr Ser Trp Lys His Ser Ile Ile Asp Asp Thr Ile Tyr Lys 
                725                 730                 735     


Pro Phe Ser Lys Ser Ala Tyr Tyr Val Gly Ile Tyr Lys Lys Pro Asn 
            740                 745                 750         


Ala Ile Thr Ser Asn Ala Ile Lys Val Leu Arg Pro Lys Leu Leu Asn 
        755                 760                 765             


Gly Glu His Thr Met Ser Lys Asn Ala Lys Tyr Tyr His Gln Lys Ile 
    770                 775                 780                 


Gly Asn Glu Arg Phe Leu Met Lys Ser Gln Lys Gly Gly Ser Ile Ile 
785                 790                 795                 800 


Thr Val Lys Pro His Asp Gly Pro Glu Lys Val Leu Gln Ile Ser Pro 
                805                 810                 815     


Thr Tyr Glu Cys Ala Val Leu Thr Lys His Asp Gly Lys Ile Ile Val 
            820                 825                 830         


Lys Phe Lys Pro Ile Lys Pro Leu Arg Asp Met Tyr Ala Arg Gly Val 
        835                 840                 845             


Ile Lys Ala Met Asp Lys Glu Leu Glu Thr Ser Leu Ser Ser Met Ser 
    850                 855                 860                 


Lys His Ala Lys Tyr Lys Glu Leu His Thr His Asp Ile Ile Tyr Leu 
865                 870                 875                 880 


Pro Ala Thr Lys Lys His Val Asp Gly Tyr Phe Ile Ile Thr Lys Leu 
                885                 890                 895     


Ser Ala Lys His Gly Ile Lys Ala Leu Pro Glu Ser Met Val Lys Val 
            900                 905                 910         


Lys Tyr Thr Gln Ile Gly Ser Glu Asn Asn Ser Glu Val Lys Leu Thr 
        915                 920                 925             


Lys Pro Lys Pro Glu Ile Thr Leu Asp Ser Glu Asp Ile Thr Asn Ile 
    930                 935                 940                 


Tyr Asn Phe Thr Arg 
945                 


<210>  2
<211>  2851
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARMAN 1

<400>  2
atgagagact ctattactgc acctagatac agctccgctc ttgccgccag aataaaggag       60

tttaattctg ctttcaagtt aggaatcgac ctaggaacaa aaaccggcgg cgtagcactg      120

gtaaaagaca acaaagtgct gctcgctaag acattcctcg attaccataa acaaacactg      180

gaggaaagga ggatccatag aagaaacaga aggagcaggc tagccaggcg gaagaggatt      240

gctcggctgc gatcatggat actcagacag aagatttatg gcaagcagct tcctgaccca      300

tacaaaatca aaaaaatgca gttgcctaat ggtgtacgaa aaggggaaaa ctggattgac      360

ctggtagttt ctggacggga cctttcacca gaagccttcg tgcgtgcaat aactctgata      420

ttccaaaaga gagggcaaag atatgaagaa gtggccaaag agatagaaga aatgagttac      480

aaggaattta gtactcacat aaaagccctg acatccgtta ctgaagaaga atttactgct      540

ctggcagcag agatagaacg gaggcaggat gtggttgaca cagacaagga ggccgaacgc      600

tatacccaat tgtctgagtt gctctccaag gtctcagaaa gcaaatctga atctaaagac      660

agagcgcagc gtaaggagga tctcggaaag gtggtgaacg ctttctgcag tgctcatcgt      720

atcgaagaca aggataaatg gtgtaaagaa cttatgaaat tactagacag accagtcaga      780

cacgctaggt tccttaacaa agtactgata cgttgcaata tctgcgatag ggcaacccct      840

aagaaatcca gacctgacgt gagggaactg ctatattttg acacagtaag aaacttcttg      900

aaggctggaa gagtggagca aaacccagac gttattagtt actataaaaa aatttatatg      960

gatgcagaag taatcagggt caaaattctg aataaggaaa agctgactga tgaggacaaa     1020

aagcaaaaga ggaaattagc gagcgaactt aacaggtaca aaaacaaaga atacgtgact     1080

gatgcgcaga agaagatgca agagcaactt aagacattgc tgttcatgaa gctgacaggc     1140

aggtctagat actgcatggc tcatcttaag gaaagggcag caggcaaaga tgtagaagaa     1200

ggacttcatg gcgttgtgca gaaaagacac gacaggaaca tagcacagcg caatcacgac     1260

ttacgtgtga ttaatcttat tgagagtctg cttttcgacc aaaacaaatc gctctccgat     1320

gcaataagga agaacgggtt aatgtatgtt actattgagg ctccagagcc aaagactaag     1380

cacgcaaaga aaggcgcagc tgtggtaagg gatcccagaa agttgaagga gaagttgttt     1440

gatgatcaaa acggcgtttg catatatacg ggcttgcagt tagacaaatt agagataagt     1500

aaatacgaga aggaccatat ctttccagat tcaagggatg gaccatctat cagggacaat     1560

cttgtactca ctacaaaaga gataaattca gacaaaggcg ataggacccc atgggaatgg     1620

atgcatgata acccagaaaa atggaaagcg ttcgagagaa gagtcgcaga attctataag     1680

aaaggcagaa taaatgagag gaaaagagaa ctcctattaa acaaaggcac tgaataccct     1740

ggcgataacc cgactgagct ggcgcgggga ggcgcccgtg ttaacaactt tattactgaa     1800

tttaatgacc gcctcaaaac gcatggagtc caggaactgc agaccatctt tgagcgtaac     1860

aaaccaatag tgcaggtagt caggggtgaa gaaacgcagc gtctgcgcag acaatggaat     1920

gcactaaacc agaatttcat accactaaag gacagggcaa tgtcgttcaa ccacgctgaa     1980

gacgcagcca tagcagcaag catgccacca aaattctgga gggagcagat ataccgtact     2040

gcgtggcact ttggacctag tggaaatgag agaccggact ttgctttggc agaattggcg     2100

ccacaatgga atgacttctt tatgactaag ggcggtccaa taatagcagt gctgggcaaa     2160

acgaagtata gttggaagca cagcataatt gatgacacta tatacaagcc attcagcaaa     2220

agtgcttact atgttgggat atacaaaaag ccgaacgcca tcacgtccaa tgctataaaa     2280

gtcttaaggc caaaactctt aaatggcgaa catacaatgt ctaagaatgc aaagtattat     2340

catcagaaga ttggtaatga gcgcttcctc atgaaatctc agaaaggtgg atcgataatt     2400

acagtaaaac cacacgacgg accggaaaaa gtgcttcaaa tcagccctac atatgaatgc     2460

gcagtcctta ctaagcatga cggtaaaata atagtcaaat ttaaaccaat aaagccgcta     2520

cgggacatgt atgcccgcgg tgtgattaaa gccatggaca aagagcttga aacaagcctc     2580

tctagcatga gtaaacacgc taagtacaag gagttacaca ctcatgatat catatatctg     2640

cctgctacaa agaagcacgt agatggctac ttcataataa ccaaactaag tgcgaaacat     2700

ggcataaaag cactccccga aagcatggtt aaagtcaagt atactcaaat tgggagtgaa     2760

aacaatagtg aagtgaagct taccaaacca aaaccagaga taactttgga tagtgaagat     2820

attacaaaca tatataattt cacccgctaa g                                    2851


<210>  3
<211>  967
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMAN 4

<400>  3

Met Leu Gly Ser Ser Arg Tyr Leu Arg Tyr Asn Leu Thr Ser Phe Glu 
1               5                   10                  15      


Gly Lys Glu Pro Phe Leu Ile Met Gly Tyr Tyr Lys Glu Tyr Asn Lys 
            20                  25                  30          


Glu Leu Ser Ser Lys Ala Gln Lys Glu Phe Asn Asp Gln Ile Ser Glu 
        35                  40                  45              


Phe Asn Ser Tyr Tyr Lys Leu Gly Ile Asp Leu Gly Asp Lys Thr Gly 
    50                  55                  60                  


Ile Ala Ile Val Lys Gly Asn Lys Ile Ile Leu Ala Lys Thr Leu Ile 
65                  70                  75                  80  


Asp Leu His Ser Gln Lys Leu Asp Lys Arg Arg Glu Ala Arg Arg Asn 
                85                  90                  95      


Arg Arg Thr Arg Leu Ser Arg Lys Lys Arg Leu Ala Arg Leu Arg Ser 
            100                 105                 110         


Trp Val Met Arg Gln Lys Val Gly Asn Gln Arg Leu Pro Asp Pro Tyr 
        115                 120                 125             


Lys Ile Met His Asp Asn Lys Tyr Trp Ser Ile Tyr Asn Lys Ser Asn 
    130                 135                 140                 


Ser Ala Asn Lys Lys Asn Trp Ile Asp Leu Leu Ile His Ser Asn Ser 
145                 150                 155                 160 


Leu Ser Ala Asp Asp Phe Val Arg Gly Leu Thr Ile Ile Phe Arg Lys 
                165                 170                 175     


Arg Gly Tyr Leu Ala Phe Lys Tyr Leu Ser Arg Leu Ser Asp Lys Glu 
            180                 185                 190         


Phe Glu Lys Tyr Ile Asp Asn Leu Lys Pro Pro Ile Ser Lys Tyr Glu 
        195                 200                 205             


Tyr Asp Glu Asp Leu Glu Glu Leu Ser Ser Arg Val Glu Asn Gly Glu 
    210                 215                 220                 


Ile Glu Glu Lys Lys Phe Glu Gly Leu Lys Asn Lys Leu Asp Lys Ile 
225                 230                 235                 240 


Asp Lys Glu Ser Lys Asp Phe Gln Val Lys Gln Arg Glu Glu Val Lys 
                245                 250                 255     


Lys Glu Leu Glu Asp Leu Val Asp Leu Phe Ala Lys Ser Val Asp Asn 
            260                 265                 270         


Lys Ile Asp Lys Ala Arg Trp Lys Arg Glu Leu Asn Asn Leu Leu Asp 
        275                 280                 285             


Lys Lys Val Arg Lys Ile Arg Phe Asp Asn Arg Phe Ile Leu Lys Cys 
    290                 295                 300                 


Lys Ile Lys Gly Cys Asn Lys Asn Thr Pro Lys Lys Glu Lys Val Arg 
305                 310                 315                 320 


Asp Phe Glu Leu Lys Met Val Leu Asn Asn Ala Arg Ser Asp Tyr Gln 
                325                 330                 335     


Ile Ser Asp Glu Asp Leu Asn Ser Phe Arg Asn Glu Val Ile Asn Ile 
            340                 345                 350         


Phe Gln Lys Lys Glu Asn Leu Lys Lys Gly Glu Leu Lys Gly Val Thr 
        355                 360                 365             


Ile Glu Asp Leu Arg Lys Gln Leu Asn Lys Thr Phe Asn Lys Ala Lys 
    370                 375                 380                 


Ile Lys Lys Gly Ile Arg Glu Gln Ile Arg Ser Ile Val Phe Glu Lys 
385                 390                 395                 400 


Ile Ser Gly Arg Ser Lys Phe Cys Lys Glu His Leu Lys Glu Phe Ser 
                405                 410                 415     


Glu Lys Pro Ala Pro Ser Asp Arg Ile Asn Tyr Gly Val Asn Ser Ala 
            420                 425                 430         


Arg Glu Gln His Asp Phe Arg Val Leu Asn Phe Ile Asp Lys Lys Ile 
        435                 440                 445             


Phe Lys Asp Lys Leu Ile Asp Pro Ser Lys Leu Arg Tyr Ile Thr Ile 
    450                 455                 460                 


Glu Ser Pro Glu Pro Glu Thr Glu Lys Leu Glu Lys Gly Gln Ile Ser 
465                 470                 475                 480 


Glu Lys Ser Phe Glu Thr Leu Lys Glu Lys Leu Ala Lys Glu Thr Gly 
                485                 490                 495     


Gly Ile Asp Ile Tyr Thr Gly Glu Lys Leu Lys Lys Asp Phe Glu Ile 
            500                 505                 510         


Glu His Ile Phe Pro Arg Ala Arg Met Gly Pro Ser Ile Arg Glu Asn 
        515                 520                 525             


Glu Val Ala Ser Asn Leu Glu Thr Asn Lys Glu Lys Ala Asp Arg Thr 
    530                 535                 540                 


Pro Trp Glu Trp Phe Gly Gln Asp Glu Lys Arg Trp Ser Glu Phe Glu 
545                 550                 555                 560 


Lys Arg Val Asn Ser Leu Tyr Ser Lys Lys Lys Ile Ser Glu Arg Lys 
                565                 570                 575     


Arg Glu Ile Leu Leu Asn Lys Ser Asn Glu Tyr Pro Gly Leu Asn Pro 
            580                 585                 590         


Thr Glu Leu Ser Arg Ile Pro Ser Thr Leu Ser Asp Phe Val Glu Ser 
        595                 600                 605             


Ile Arg Lys Met Phe Val Lys Tyr Gly Tyr Glu Glu Pro Gln Thr Leu 
    610                 615                 620                 


Val Gln Lys Gly Lys Pro Ile Ile Gln Val Val Arg Gly Arg Asp Thr 
625                 630                 635                 640 


Gln Ala Leu Arg Trp Arg Trp His Ala Leu Asp Ser Asn Ile Ile Pro 
                645                 650                 655     


Glu Lys Asp Arg Lys Ser Ser Phe Asn His Ala Glu Asp Ala Val Ile 
            660                 665                 670         


Ala Ala Cys Met Pro Pro Tyr Tyr Leu Arg Gln Lys Ile Phe Arg Glu 
        675                 680                 685             


Glu Ala Lys Ile Lys Arg Lys Val Ser Asn Lys Glu Lys Glu Val Thr 
    690                 695                 700                 


Arg Pro Asp Met Pro Thr Lys Lys Ile Ala Pro Asn Trp Ser Glu Phe 
705                 710                 715                 720 


Met Lys Thr Arg Asn Glu Pro Val Ile Glu Val Ile Gly Lys Val Lys 
                725                 730                 735     


Pro Ser Trp Lys Asn Ser Ile Met Asp Gln Thr Phe Tyr Lys Tyr Leu 
            740                 745                 750         


Leu Lys Pro Phe Lys Asp Asn Leu Ile Lys Ile Pro Asn Val Lys Asn 
        755                 760                 765             


Thr Tyr Lys Trp Ile Gly Val Asn Gly Gln Thr Asp Ser Leu Ser Leu 
    770                 775                 780                 


Pro Ser Lys Val Leu Ser Ile Ser Asn Lys Lys Val Asp Ser Ser Thr 
785                 790                 795                 800 


Val Leu Leu Val His Asp Lys Lys Gly Gly Lys Arg Asn Trp Val Pro 
                805                 810                 815     


Lys Ser Ile Gly Gly Leu Leu Val Tyr Ile Thr Pro Lys Asp Gly Pro 
            820                 825                 830         


Lys Arg Ile Val Gln Val Lys Pro Ala Thr Gln Gly Leu Leu Ile Tyr 
        835                 840                 845             


Arg Asn Glu Asp Gly Arg Val Asp Ala Val Arg Glu Phe Ile Asn Pro 
    850                 855                 860                 


Val Ile Glu Met Tyr Asn Asn Gly Lys Leu Ala Phe Val Glu Lys Glu 
865                 870                 875                 880 


Asn Glu Glu Glu Leu Leu Lys Tyr Phe Asn Leu Leu Glu Lys Gly Gln 
                885                 890                 895     


Lys Phe Glu Arg Ile Arg Arg Tyr Asp Met Ile Thr Tyr Asn Ser Lys 
            900                 905                 910         


Phe Tyr Tyr Val Thr Lys Ile Asn Lys Asn His Arg Val Thr Ile Gln 
        915                 920                 925             


Glu Glu Ser Lys Ile Lys Ala Glu Ser Asp Lys Val Lys Ser Ser Ser 
    930                 935                 940                 


Gly Lys Glu Tyr Thr Arg Lys Glu Thr Glu Glu Leu Ser Leu Gln Lys 
945                 950                 955                 960 


Leu Ala Glu Leu Ile Ser Ile 
                965         


<210>  4
<211>  2906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARMAN 4

<400>  4
atgttaggct ccagcaggta cctccgttat aacctaacct cgtttgaagg caaggagcca       60

tttttaataa tgggatatta caaagagtat aataaggaat taagttccaa agctcaaaaa      120

gaatttaatg atcaaatttc tgaatttaat tcgtattaca aactaggtat agatctcgga      180

gataaaacag gaattgcaat cgtaaagggc aacaaaataa tcctagcaaa aacactaatt      240

gatttgcatt cccaaaaatt agataaaaga agggaagcta gaagaaatag aagaactcgg      300

ctttccagaa agaaaaggct tgcgagatta agatcgtggg taatgcgtca gaaagttggc      360

aatcaaagac ttcccgatcc atataaaata atgcatgaca ataagtactg gtctatatat      420

aataagagta attctgcaaa taaaaagaat tggatagatc tgttaatcca cagtaactct      480

ttatcagcag acgattttgt tagaggctta actataattt tcagaaaaag aggctattta      540

gcatttaagt atctttcaag gttaagcgat aaggaatttg aaaaatacat agataactta      600

aaaccaccta taagcaaata cgagtatgat gaggatttag aagaattatc aagcagggtt      660

gaaaatgggg aaatagagga aaagaaattc gaaggcttaa agaataagct agataaaata      720

gacaaagaat ctaaagactt tcaagtaaag caaagagaag aagtaaaaaa ggaactggaa      780

gacttagttg atttgtttgc taaatcagtt gataataaaa tagataaagc taggtggaaa      840

agggagctaa ataatttatt ggataagaaa gtaaggaaaa tacggtttga caaccgcttt      900

attttgaagt gcaaaattaa gggctgtaac aagaatactc caaagaaaga gaaggtcaga      960

gattttgaat tgaagatggt tttaaataat gctagaagcg attatcagat ttctgatgag     1020

gatttaaact cttttagaaa tgaagtaata aatatatttc aaaagaagga aaacttaaag     1080

aaaggagagc tgaaaggagt tactattgaa gatttgagaa agcagcttaa taaaactttt     1140

aataaagcca agattaaaaa agggataagg gagcagataa ggtctatcgt gtttgaaaaa     1200

attagtggaa ggagtaaatt ctgcaaagaa catctaaaag aattttctga gaagccggct     1260

ccttctgaca ggattaatta tggggttaat tcagcaagag aacaacatga ttttagagtc     1320

ttaaatttca tagataaaaa aatattcaaa gataagttga tagatccctc aaaattgagg     1380

tatataacta ttgaatctcc agaaccagaa acagagaagt tggaaaaagg tcaaatatca     1440

gagaagagct tcgaaacatt gaaagaaaaa ttggctaaag aaacaggtgg tattgatata     1500

tacactggtg aaaaattaaa gaaagacttt gaaatagagc acatattccc aagagcaagg     1560

atggggcctt ctataaggga aaacgaagta gcatcaaatc tggaaacaaa taaggaaaag     1620

gccgatagaa ctccttggga atggtttggg caagatgaaa aaagatggtc agagtttgag     1680

aaaagagtta attctcttta tagtaaaaag aaaatatcag agagaaaaag agaaattttg     1740

ttaaataaga gtaatgaata tccgggatta aaccctacag aactaagtag aatacctagt     1800

acgctgagcg acttcgttga gagtataaga aaaatgtttg ttaagtatgg ctatgaagag     1860

cctcaaactt tggttcaaaa aggaaaaccg ataatacaag ttgttagagg cagagacaca     1920

caagctttga ggtggagatg gcatgcatta gatagtaata taataccaga aaaggacagg     1980

aaaagttcat ttaatcacgc tgaagatgca gttattgccg cctgtatgcc accttactat     2040

ctcaggcaaa aaatatttag agaagaagca aaaataaaaa gaaaagtaag caataaggaa     2100

aaggaagtta cacggcctga catgcctact aaaaagatag ctccgaactg gtcggaattt     2160

atgaaaacta gaaatgagcc ggttattgaa gtaataggaa aagttaagcc aagctggaaa     2220

aacagcataa tggatcaaac attttataaa tatcttttga agccatttaa agataacctg     2280

ataaaaatac ccaacgttaa aaatacatac aagtggatag gagttaatgg acaaactgat     2340

tcattatccc tcccgagtaa ggtcttatct atctctaata aaaaggttga ttcttctaca     2400

gttcttcttg tgcatgataa gaagggtggt aagcggaatt gggtacctaa aagtataggg     2460

ggtttgttgg tatatataac tcctaaagac gggccgaaaa gaatagttca agtaaagcca     2520

gcaactcagg gtttgttaat atatagaaat gaagatggca gagtagatgc tgtaagagag     2580

ttcataaatc cagtgataga aatgtataat aatggcaaat tggcatttgt agaaaaagaa     2640

aatgaagaag agcttttgaa atattttaat ttgctggaaa aaggtcaaaa atttgaaaga     2700

ataagacggt atgatatgat aacctacaat agtaaatttt actatgtaac aaaaataaac     2760

aagaatcaca gagttactat acaagaagag tctaagataa aagcagaatc agacaaagtt     2820

aagtcctctt caggcaaaga gtatactcgt aaggaaaccg aggaattatc acttcaaaaa     2880

ttagcggaat taattagtat ataaaa                                          2906


<210>  5
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX.1

<400>  5

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  6
<211>  5495
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX.1

<400>  6
atgcttctta tttatcggag atatcttcaa acaccatcaa catggcaatg gtgaaccatt       60

aatattcttt gatgcttctt atttatcgga gatatcttca aacattgccc attttacagg      120

catatcttct ggctctttga tgcttcttat ttatcggaga tatcttcaaa cgtaatgtat      180

tgagaaagac atcaagatta gataactttg atgcttctta tttatcggag atatcttcaa      240

acacagaaac ctgcaaagat tgtatatata taagctttga tgcttcttat ttatcggaga      300

tatcttcaaa cgatacgtat tttagcccgt ctatttgggg attaactttg atgcttctta      360

tttatcggag atatcttcaa accccgcata tccagatttt tcaatgactt ctggaaattg      420

tattttcaat attttacaag ttgcggagga tacctttaat aatttagcag agttacgcac      480

tgtaaacctg ttcttctcac aaaaagcttt aacatcagat tttcaaagaa cttcttatgt      540

aatttataag aatctaaaaa aacagctctg ggtttgcatc cagaactctc cgataaataa      600

gcgctttacc catacgacat agtcgctggt gatggctctc aaagtaatga gataaaagcg      660

ccagtaataa tttactattc acaaatcctt tcgtcaagct taaaatcaat caaagaccat      720

atccccttca ttccaaatag cagcgcttcc gtacctttct atccgttcat atatctcctc      780

tgagagagga taaattacca gacttataga gccatccata aatccttttt ctttaaggtt      840

gagctttaga tcagcccacc ttgcttttga aaggttaaac tcaaagacag aatattgaat      900

ccgaacacca taggcttcca gaagtttaac taaccgtgcc ctgaccttat catcttcaat      960

atcataacaa atgagatgtc gcattttaaa gctctatagg cttataacat tccctatcat     1020

cttgaatatg ctggctaaac aacctaacct gccgctcaac tgcgtgctga tacgttattg     1080

attggataag taaattggtt ttctgctcat ctaccttaaa gaattgatgc cattttttga     1140

ttacttttgg ataggcatcc ttattcagcc aaacaccttt ttggtcagtt tctttcctga     1200

aatcgtctgt atccacttcc cttctattta tcaaattgat cacaaaacgg tcagccaacg     1260

gccgccactc ctccagaaga tcgcatatta aagagggacg accataatag acgtcatgca     1320

agtaaccaaa ggccgggtca aaaccgacga gtaatgcagt cgaatgtatt tcgttgaaca     1380

ggagggtgta gataaggctc atcatggcgt tgatttcatc ctcaggaggt ctcttggtac     1440

ggcgcacaaa aacaaagctt ggatgcttta agatagccga aaaattgcca taatactgcc     1500

ttgttgttgc gccttctatt ccacgcaagg tctctaaatc agtgacggcg ttgatttcgg     1560

tacactcgat tctcaaacca agtctatatt tatcaagtaa tgattgctgg tttttgatct     1620

taccggcaac gatacttttt gcaatttcaa gttttttgtg gggatcaaaa tgcttatgaa     1680

tttgcgcccg acgaataaac agatttttga cgggttcaaa ttgaaggctc ccttgatatt     1740

cccatctgcc gctaaagaaa tgtatcggta tagattattc tctgcaaagg ctaataacac     1800

ggctatcgag ggtaacccgg ccaactacca cgatatcttt taccttcatt gcgggaatct     1860

tctgcccctt ctcttcattg tcctttttta tgagaaatgc ccgaccacga caatccaaaa     1920

tgaattcatc acccgtgaga tagagggtta tcctgtcggt tatagcggtc atcagtaagc     1980

cttttatttt tctaaccaag tattgaagga agacacgatt cactatactg gcactgcgga     2040

cacctatggt catcaacctt gggaaacctg cttatatcaa aggacaagaa gcagtctcgc     2100

agatttgtaa caacttctac acaacgcact ttcagggttt tatctataac aatttctttc     2160

cgtctccgtg tttcacagaa aaatatttca ccaactggta tattgacatt atacatctct     2220

tcaaggcaaa ttgcctgtaa cccaatctga acgtggaagt tctcaaaatc ccttaccttc     2280

cctgtctttg tttcgatagg aatcggtatc ccatccctcc actcgataag gtctgcccgg     2340

cctgccaaac cgagcttatt gctgtaaaga tacacgcctg ttacctgctt acaatcaggg     2400

cagcttctct gcgatgattt atccaccgcc ctgtgcgcgt gtatggcctc tgtaaagtgg     2460

atgctcttag ccatattacg ccgttctcca acaaaggcat accatgcatt gcgcggacaa     2520

tagattgact ccattaccgt gctgatgtgc aatatcagac ggctggtttc catacttctt     2580

tgagcttctt tctgtaaaag gattgccatg tttcaacaaa tgcccttttg tcagtatttc     2640

cggtcgtttt attggtttga tacttcttat attcttgaga acggagaaag agccacgacc     2700

ttgcaatatt cagtgctgct tgttcgtctg catgggtttc aaaaccacag ttcaggcaaa     2760

caaacttttc ctgcaccggc ctgtgactaa atctcttttt tagcagagat aaagcttcac     2820

cactgcggcc ttttgtccaa ctagaaatat cattatttac cgactcttcc gaaagtctat     2880

ccagctctac agagaggtct tttaccacat tctgcctttt ataccggtta tagtatgtta     2940

tctgtccttc aacttttaac tcttttccat tgattgtagt catccatcca gtagccgtct     3000

tcttgagctt ttcgagcacc ctgtcataat ctgcacttgt gattgtaaaa ccacaattag     3060

aacatgtctt tgaggtatac tgtgccagag tctttgaaag ataggttttt gatggcagac     3120

cttcataggc aagctttgca gtcagccagt cttccatcct cgtgtactgc ctttccgcca     3180

taaaagtcct cttgccttgt ctaccaaaac cgcgggaaag attttcaaaa atgagcattg     3240

catcttgagt aacagcataa tataagaggt cacgagctgt atttcttacc atatcgtccg     3300

ccagattctt cgcctttgat gcatattttc tcgaatatcc gcctgcccgc ctttgttcaa     3360

cttctttagc agcctgaata gtccgttgtt tttccttata actttctcct attcgcaaaa     3420

tatgcgttgg attgcccaat gaatctttga atcttgacaa ggggcatcct tccgggtctg     3480

ttaatgctat gactgccggg atattttctc cccggtctat tcctatcaga ttcatcggtt     3540

ttatattcga tgagtcaagc acctctcttc tttcaaatgt cagggcaaca aaaagtgctg     3600

gttcatcctg tctcgtcctt ctgttataga gcgttttttc aataaccctg ccattggcga     3660

gtttcaatga acccgtctca aggctcaata ggtcgttcca gataaactcc ctcccctgcc     3720

tttttccaaa ggccaaaggc agaattatca aattcgggtc atcaaaattg aagttgacct     3780

ccataggcac aatctcaccg ctttttttat taattactgt ataaaaccta tttgcttcaa     3840

aagcttctgg cttgattttt ttgaagcgta gcttaccacc tttgaagtaa tttattatta     3900

aataaagatt taacttcttt acgccgtctt tctgccatat aaatgcacaa ttatactgtt     3960

tagaaaatcc gcttatatct aaaatgctgt tctctgcttc tatagcaaat ggttttcctc     4020

tcaaatctcc ataccacttt tgaagcttta actcacacct gcaaaactca tccttatcag     4080

cttctttgag cccttcaata acaaaagagg cctttgccct gagccaatca gtgagggcag     4140

cctttgattg agcatcttca gaccttcttt cttcctccaa ctttatgtgc ttactcagac     4200

cttcaacttt tttatctatt ctttcccatg cctcatcata aactttgccc caatcttcac     4260

cgtgtttctt ttcaaggtga agcaaaaggt caccaaactg ataacgcgca aacttttttc     4320

cttttttacg gtcttcttca gacgaaagat atggaagcaa ggcttcctgc cttttatatc     4380

cagcaagatt ttgccagaag accttcccgt cctctttctt ttcgttaatc aactttttga     4440

cattacagac catatcccac caatcaacct cattcgcctg gcgttcaaca agagggaagg     4500

acggaaaacc cttaagccgc tgtaagggct ttgcctcatc cctgccaatt ttgagtttct     4560

gccaaagatt caggtttacc cagatcacta tctgagcaac aacattgtta taagcttcaa     4620

tcccttcttt tgtatgcggt tgcggtggaa gagtgatttt aggaaatgca agcccgtttg     4680

cacttgctat atcctttaga tttgccaatc tcttttcgtt tttttttata accttttggt     4740

gttcgaggat gatgtcctgg tactttgtaa ggaaactggc tactgctccc atacaggcat     4800

cagataaagc cttaccaacg ggaccacttg cgcagctatt gccaccgatc tgttctagcg     4860

gctttacagg atggttcgat tctcttgtta cgtggattga ataaaagtcc aatgcccttt     4920

gaccgaactt ccccaacgaa tacgttacta gctcgtcatt tgcctccggt ttatgcggcg     4980

agagcaatat caaacgttca tgctcggaga cattacaacg gccaaagtaa tttgtatggg     5040

gcttaccctt gtcattcact tgttcaagct tataaacata gaggggttga cagcactgag     5100

aacaggcaaa tccagaactt gttagtctct catttccgtc cttcaccgga atcaattttc     5160

tctgatcaat attcttgggc gctggttgtg caaccctgct catcaatccg acagggtctt     5220

tttggaactc ttcccaataa acatgcagga ttgctttctt catttccgta tagtcagtga     5280

ggagtttatt taaatttgca cgtgaagtat ttgaaatggg ctgaggaatg ttttccggct     5340

ttttgcgaag attctctaac ctttctctca ggtcaggtgt cataacccga acgagcaagg     5400

ttttcatagg gccggttttg ccggcttttt tcgtgttgct atcctttacc aatctccttc     5460

gtattttatt tatccttttt atttcctgca tcttt                                5495


<210>  7
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX.1 deltaproteobacteria

<400>  7

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr 
            820                 825                 830         


Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly 
        835                 840                 845             


Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser 
865                 870                 875                 880 


Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser 
                885                 890                 895     


Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys 
        915                 920                 925             


Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  8
<211>  2962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX.1 deltaproteobacteria

<400>  8
atggaaaaga gaataaacaa gatacgaaag aaactatcgg ccgataatgc cacaaagcct       60

gtgagcagga gcggccccat gaaaacactc cttgtccggg tcatgacgga cgacttgaaa      120

aaaagactgg agaagcgtcg gaaaaagccg gaagttatgc cgcaggttat ttcaaataac      180

gcagcaaaca atcttagaat gctccttgat gactatacaa agatgaagga ggcgatacta      240

caagtttact ggcaggaatt taaggacgac catgtgggct tgatgtgcaa atttgcccag      300

cctgcttcca aaaaaattga ccagaacaaa ctaaaaccgg aaatggatga aaaaggaaat      360

ctaacaactg ccggttttgc atgttctcaa tgcggtcagc cgctatttgt ttataagctt      420

gaacaggtga gtgaaaaagg caaggcttat acaaattact tcggccggtg taatgtggcc      480

gagcatgaga aattgattct tcttgctcaa ttaaaacctg aaaaagacag tgacgaagca      540

gtgacatact cccttggcaa attcggccag agggcattgg acttttattc aatccacgta      600

acaaaagaat ccacccatcc agtaaagccc ctggcacaga ttgcgggcaa ccgctatgca      660

agcggacctg ttggcaaggc cctttccgat gcctgtatgg gcactatagc cagttttctt      720

tcgaaatatc aagacatcat catagaacat caaaaggttg tgaagggtaa tcaaaagagg      780

ttagagagtc tcagggaatt ggcagggaaa gaaaatcttg agtacccatc ggttacactg      840

ccgccgcagc cgcatacgaa agaaggggtt gacgcttata acgaagttat tgcaagggta      900

cgtatgtggg ttaatcttaa tctgtggcaa aagctgaagc tcagccgtga tgacgcaaaa      960

ccgctactgc ggctaaaagg attcccatct ttccctgttg tggagcggcg tgaaaacgaa     1020

gttgactggt ggaatacgat taatgaagta aaaaaactga ttgacgctaa acgagatatg     1080

ggacgggtat tctggagcgg cgttaccgca gaaaagagaa ataccatcct tgaaggatac     1140

aactatctgc caaatgagaa tgaccataaa aagagagagg gcagtttgga aaaccctaag     1200

aagcctgcca aacgccagtt tggagacctc ttgctgtatc ttgaaaagaa atatgccgga     1260

gactggggaa aggtcttcga tgaggcatgg gagaggatag ataagaaaat agccggactc     1320

acaagccata tagagcgcga agaagcaaga aacgcggaag acgctcaatc caaagccgta     1380

cttacagact ggctaagggc aaaggcatca tttgttcttg aaagactgaa ggaaatggat     1440

gaaaaggaat tctatgcgtg tgaaatccaa cttcaaaaat ggtatggcga tcttcgaggc     1500

aacccgtttg ccgttgaagc tgagaataga gttgttgata taagcgggtt ttctatcgga     1560

agcgatggcc attcaatcca atacagaaat ctccttgcct ggaaatatct ggagaacggc     1620

aagcgtgaat tctatctgtt aatgaattat ggcaagaaag ggcgcatcag atttacagat     1680

ggaacagata ttaaaaagag cggcaaatgg cagggactat tatatggcgg tggcaaggca     1740

aaggttattg atctgacttt cgaccccgat gatgaacagt tgataatcct gccgctggcc     1800

tttggcacaa ggcaaggccg cgagtttatc tggaacgatt tgctgagtct tgaaacaggc     1860

ctgataaagc tcgcaaacgg aagagttatc gaaaaaacaa tctataacaa aaaaataggg     1920

cgggatgaac cggctctatt cgttgcctta acatttgagc gccgggaagt tgttgatcca     1980

tcaaatataa agcctgtaaa ccttataggc gttgaccgcg gcgaaaacat cccggcggtt     2040

attgcattga cagaccctga aggttgtcct ttaccggaat tcaaggattc atcagggggc     2100

ccaacagaca tcctgcgaat aggagaagga tataaggaaa agcagagggc tattcaggca     2160

gcaaaggagg tagagcaaag gcgggctggc ggttattcac ggaagtttgc atccaagtcg     2220

aggaacctgg cggacgacat ggtgagaaat tcagcgcgag acctttttta ccatgccgtt     2280

acccacgatg ccgtccttgt ctttgaaaac ctgagcaggg gttttggaag gcagggcaaa     2340

aggaccttca tgacggaaag acaatataca aagatggaag actggctgac agcgaagctc     2400

gcatacgaag gtcttacgtc aaaaacctac ctttcaaaga cgctggcgca atatacgtca     2460

aaaacatgct ccaactgcgg gtttactata acgactgccg attatgacgg gatgttggta     2520

aggcttaaaa agacttctga tggatgggca actaccctca acaacaaaga attaaaagcc     2580

gaaggccaga taacgtatta taaccggtat aaaaggcaaa ccgtggaaaa agaactctcc     2640

gcagagcttg acaggctttc agaagagtcg ggcaataatg atatttctaa gtggaccaag     2700

ggtcgccggg acgaggcatt atttttgtta aagaaaagat tcagccatcg gcctgttcag     2760

gaacagtttg tttgcctcga ttgcggccat gaagtccacg ccgatgaaca ggcagccttg     2820

aatattgcaa ggtcatggct ttttctaaac tcaaattcaa cagaattcaa aagttataaa     2880

tcgggtaaac agcccttcgt tggtgcttgg caggcctttt acaaaaggag gcttaaagag     2940

gtatggaagc ccaacgcctg at                                              2962


<210>  9
<211>  1125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasY.1

<400>  9

Met Arg Lys Lys Leu Phe Lys Gly Tyr Ile Leu His Asn Lys Arg Leu 
1               5                   10                  15      


Val Tyr Thr Gly Lys Ala Ala Ile Arg Ser Ile Lys Tyr Pro Leu Val 
            20                  25                  30          


Ala Pro Asn Lys Thr Ala Leu Asn Asn Leu Ser Glu Lys Ile Ile Tyr 
        35                  40                  45              


Asp Tyr Glu His Leu Phe Gly Pro Leu Asn Val Ala Ser Tyr Ala Arg 
    50                  55                  60                  


Asn Ser Asn Arg Tyr Ser Leu Val Asp Phe Trp Ile Asp Ser Leu Arg 
65                  70                  75                  80  


Ala Gly Val Ile Trp Gln Ser Lys Ser Thr Ser Leu Ile Asp Leu Ile 
                85                  90                  95      


Ser Lys Leu Glu Gly Ser Lys Ser Pro Ser Glu Lys Ile Phe Glu Gln 
            100                 105                 110         


Ile Asp Phe Glu Leu Lys Asn Lys Leu Asp Lys Glu Gln Phe Lys Asp 
        115                 120                 125             


Ile Ile Leu Leu Asn Thr Gly Ile Arg Ser Ser Ser Asn Val Arg Ser 
    130                 135                 140                 


Leu Arg Gly Arg Phe Leu Lys Cys Phe Lys Glu Glu Phe Arg Asp Thr 
145                 150                 155                 160 


Glu Glu Val Ile Ala Cys Val Asp Lys Trp Ser Lys Asp Leu Ile Val 
                165                 170                 175     


Glu Gly Lys Ser Ile Leu Val Ser Lys Gln Phe Leu Tyr Trp Glu Glu 
            180                 185                 190         


Glu Phe Gly Ile Lys Ile Phe Pro His Phe Lys Asp Asn His Asp Leu 
        195                 200                 205             


Pro Lys Leu Thr Phe Phe Val Glu Pro Ser Leu Glu Phe Ser Pro His 
    210                 215                 220                 


Leu Pro Leu Ala Asn Cys Leu Glu Arg Leu Lys Lys Phe Asp Ile Ser 
225                 230                 235                 240 


Arg Glu Ser Leu Leu Gly Leu Asp Asn Asn Phe Ser Ala Phe Ser Asn 
                245                 250                 255     


Tyr Phe Asn Glu Leu Phe Asn Leu Leu Ser Arg Gly Glu Ile Lys Lys 
            260                 265                 270         


Ile Val Thr Ala Val Leu Ala Val Ser Lys Ser Trp Glu Asn Glu Pro 
        275                 280                 285             


Glu Leu Glu Lys Arg Leu His Phe Leu Ser Glu Lys Ala Lys Leu Leu 
    290                 295                 300                 


Gly Tyr Pro Lys Leu Thr Ser Ser Trp Ala Asp Tyr Arg Met Ile Ile 
305                 310                 315                 320 


Gly Gly Lys Ile Lys Ser Trp His Ser Asn Tyr Thr Glu Gln Leu Ile 
                325                 330                 335     


Lys Val Arg Glu Asp Leu Lys Lys His Gln Ile Ala Leu Asp Lys Leu 
            340                 345                 350         


Gln Glu Asp Leu Lys Lys Val Val Asp Ser Ser Leu Arg Glu Gln Ile 
        355                 360                 365             


Glu Ala Gln Arg Glu Ala Leu Leu Pro Leu Leu Asp Thr Met Leu Lys 
    370                 375                 380                 


Glu Lys Asp Phe Ser Asp Asp Leu Glu Leu Tyr Arg Phe Ile Leu Ser 
385                 390                 395                 400 


Asp Phe Lys Ser Leu Leu Asn Gly Ser Tyr Gln Arg Tyr Ile Gln Thr 
                405                 410                 415     


Glu Glu Glu Arg Lys Glu Asp Arg Asp Val Thr Lys Lys Tyr Lys Asp 
            420                 425                 430         


Leu Tyr Ser Asn Leu Arg Asn Ile Pro Arg Phe Phe Gly Glu Ser Lys 
        435                 440                 445             


Lys Glu Gln Phe Asn Lys Phe Ile Asn Lys Ser Leu Pro Thr Ile Asp 
    450                 455                 460                 


Val Gly Leu Lys Ile Leu Glu Asp Ile Arg Asn Ala Leu Glu Thr Val 
465                 470                 475                 480 


Ser Val Arg Lys Pro Pro Ser Ile Thr Glu Glu Tyr Val Thr Lys Gln 
                485                 490                 495     


Leu Glu Lys Leu Ser Arg Lys Tyr Lys Ile Asn Ala Phe Asn Ser Asn 
            500                 505                 510         


Arg Phe Lys Gln Ile Thr Glu Gln Val Leu Arg Lys Tyr Asn Asn Gly 
        515                 520                 525             


Glu Leu Pro Lys Ile Ser Glu Val Phe Tyr Arg Tyr Pro Arg Glu Ser 
    530                 535                 540                 


His Val Ala Ile Arg Ile Leu Pro Val Lys Ile Ser Asn Pro Arg Lys 
545                 550                 555                 560 


Asp Ile Ser Tyr Leu Leu Asp Lys Tyr Gln Ile Ser Pro Asp Trp Lys 
                565                 570                 575     


Asn Ser Asn Pro Gly Glu Val Val Asp Leu Ile Glu Ile Tyr Lys Leu 
            580                 585                 590         


Thr Leu Gly Trp Leu Leu Ser Cys Asn Lys Asp Phe Ser Met Asp Phe 
        595                 600                 605             


Ser Ser Tyr Asp Leu Lys Leu Phe Pro Glu Ala Ala Ser Leu Ile Lys 
    610                 615                 620                 


Asn Phe Gly Ser Cys Leu Ser Gly Tyr Tyr Leu Ser Lys Met Ile Phe 
625                 630                 635                 640 


Asn Cys Ile Thr Ser Glu Ile Lys Gly Met Ile Thr Leu Tyr Thr Arg 
                645                 650                 655     


Asp Lys Phe Val Val Arg Tyr Val Thr Gln Met Ile Gly Ser Asn Gln 
            660                 665                 670         


Lys Phe Pro Leu Leu Cys Leu Val Gly Glu Lys Gln Thr Lys Asn Phe 
        675                 680                 685             


Ser Arg Asn Trp Gly Val Leu Ile Glu Glu Lys Gly Asp Leu Gly Glu 
    690                 695                 700                 


Glu Lys Asn Gln Glu Lys Cys Leu Ile Phe Lys Asp Lys Thr Asp Phe 
705                 710                 715                 720 


Ala Lys Ala Lys Glu Val Glu Ile Phe Lys Asn Asn Ile Trp Arg Ile 
                725                 730                 735     


Arg Thr Ser Lys Tyr Gln Ile Gln Phe Leu Asn Arg Leu Phe Lys Lys 
            740                 745                 750         


Thr Lys Glu Trp Asp Leu Met Asn Leu Val Leu Ser Glu Pro Ser Leu 
        755                 760                 765             


Val Leu Glu Glu Glu Trp Gly Val Ser Trp Asp Lys Asp Lys Leu Leu 
    770                 775                 780                 


Pro Leu Leu Lys Lys Glu Lys Ser Cys Glu Glu Arg Leu Tyr Tyr Ser 
785                 790                 795                 800 


Leu Pro Leu Asn Leu Val Pro Ala Thr Asp Tyr Lys Glu Gln Ser Ala 
                805                 810                 815     


Glu Ile Glu Gln Arg Asn Thr Tyr Leu Gly Leu Asp Val Gly Glu Phe 
            820                 825                 830         


Gly Val Ala Tyr Ala Val Val Arg Ile Val Arg Asp Arg Ile Glu Leu 
        835                 840                 845             


Leu Ser Trp Gly Phe Leu Lys Asp Pro Ala Leu Arg Lys Ile Arg Glu 
    850                 855                 860                 


Arg Val Gln Asp Met Lys Lys Lys Gln Val Met Ala Val Phe Ser Ser 
865                 870                 875                 880 


Ser Ser Thr Ala Val Ala Arg Val Arg Glu Met Ala Ile His Ser Leu 
                885                 890                 895     


Arg Asn Gln Ile His Ser Ile Ala Leu Ala Tyr Lys Ala Lys Ile Ile 
            900                 905                 910         


Tyr Glu Ile Ser Ile Ser Asn Phe Glu Thr Gly Gly Asn Arg Met Ala 
        915                 920                 925             


Lys Ile Tyr Arg Ser Ile Lys Val Ser Asp Val Tyr Arg Glu Ser Gly 
    930                 935                 940                 


Ala Asp Thr Leu Val Ser Glu Met Ile Trp Gly Lys Lys Asn Lys Gln 
945                 950                 955                 960 


Met Gly Asn His Ile Ser Ser Tyr Ala Thr Ser Tyr Thr Cys Cys Asn 
                965                 970                 975     


Cys Ala Arg Thr Pro Phe Glu Leu Val Ile Asp Asn Asp Lys Glu Tyr 
            980                 985                 990         


Glu Lys Gly Gly Asp Glu Phe Ile  Phe Asn Val Gly Asp  Glu Lys Lys 
        995                 1000                 1005             


Val Arg  Gly Phe Leu Gln Lys  Ser Leu Leu Gly Lys  Thr Ile Lys 
    1010                 1015                 1020             


Gly Lys  Glu Val Leu Lys Ser  Ile Lys Glu Tyr Ala  Arg Pro Pro 
    1025                 1030                 1035             


Ile Arg  Glu Val Leu Leu Glu  Gly Glu Asp Val Glu  Gln Leu Leu 
    1040                 1045                 1050             


Lys Arg  Arg Gly Asn Ser Tyr  Ile Tyr Arg Cys Pro  Phe Cys Gly 
    1055                 1060                 1065             


Tyr Lys  Thr Asp Ala Asp Ile  Gln Ala Ala Leu Asn  Ile Ala Cys 
    1070                 1075                 1080             


Arg Gly  Tyr Ile Ser Asp Asn  Ala Lys Asp Ala Val  Lys Glu Gly 
    1085                 1090                 1095             


Glu Arg  Lys Leu Asp Tyr Ile  Leu Glu Val Arg Lys  Leu Trp Glu 
    1100                 1105                 1110             


Lys Asn  Gly Ala Val Leu Arg  Ser Ala Lys Phe Leu  
    1115                 1120                 1125 


<210>  10
<211>  3380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasY.1

<400>  10
atgcgcaaaa aattgtttaa gggttacatt ttacataata agaggcttgt atatacaggt       60

aaagctgcaa tacgttctat taaatatcca ttagtcgctc caaataaaac agccttaaac      120

aatttatcag aaaagataat ttatgattat gagcatttat tcggaccttt aaatgtggct      180

agctatgcaa gaaattcaaa caggtacagc cttgtggatt tttggataga tagcttgcga      240

gcaggtgtaa tttggcaaag caaaagtact tcgctaattg atttgataag taagctagaa      300

ggatctaaat ccccatcaga aaagatattt gaacaaatag attttgagct aaaaaataag      360

ttggataaag agcaattcaa agatattatt cttcttaata caggaattcg ttctagcagt      420

aatgttcgca gtttgagggg gcgctttcta aagtgtttta aagaggaatt tagagatacc      480

gaagaggtta tcgcctgtgt agataaatgg agcaaggacc ttatcgtaga gggtaaaagt      540

atactagtga gtaaacagtt tctttattgg gaagaagagt ttggtattaa aatttttcct      600

cattttaaag ataatcacga tttaccaaaa ctaacttttt ttgtggagcc ttccttggaa      660

tttagtccgc acctcccttt agccaactgt cttgagcgtt tgaaaaaatt cgatatttcg      720

cgtgaaagtt tgctcgggtt agacaataat ttttcggcct tttctaatta tttcaatgag      780

ctttttaact tattgtccag gggggagatt aaaaagattg taacagctgt ccttgctgtt      840

tctaaatcgt gggagaatga gccagaattg gaaaagcgct tacatttttt gagtgagaag      900

gcaaagttat tagggtaccc taagcttact tcttcgtggg cggattatag aatgattatt      960

ggcggaaaaa ttaaatcttg gcattctaac tataccgaac aattaataaa agttagagag     1020

gacttaaaga aacatcaaat cgcccttgat aaattacagg aagatttaaa aaaagtagta     1080

gatagctctt taagagaaca aatagaagct caacgagaag ctttgcttcc tttgcttgat     1140

accatgttaa aagaaaaaga tttttccgat gatttagagc tttacagatt tatcttgtca     1200

gattttaaga gtttgttaaa tgggtcttat caaagatata ttcaaacaga agaggagaga     1260

aaggaggaca gagatgttac caaaaaatat aaagatttat atagtaattt gcgcaacata     1320

cctagatttt ttggggaaag taaaaaggaa caattcaata aatttataaa taaatctctc     1380

ccgaccatag atgttggttt aaaaatactt gaggatattc gtaatgctct agaaactgta     1440

agtgttcgca aacccccttc aataacagaa gagtatgtaa caaagcaact tgagaagtta     1500

agtagaaagt acaaaattaa cgcctttaat tcaaacagat ttaaacaaat aactgaacag     1560

gtgctcagaa aatataataa cggagaacta ccaaagatct cggaggtttt ttatagatac     1620

ccgagagaat ctcatgtggc tataagaata ttacctgtta aaataagcaa tccaagaaag     1680

gatatatctt atcttctcga caaatatcaa attagccccg actggaaaaa cagtaaccca     1740

ggagaagttg tagatttgat agagatatat aaattgacat tgggttggct cttgagttgt     1800

aacaaggatt tttcgatgga tttttcatcg tatgacttga aactcttccc agaagccgct     1860

tccctcataa aaaattttgg ctcttgcttg agtggttact atttaagcaa aatgatattt     1920

aattgcataa ccagtgaaat aaaggggatg attactttat atactagaga caagtttgtt     1980

gttagatatg ttacacaaat gataggtagc aatcagaaat ttcctttgtt atgtttggtg     2040

ggagagaaac agactaaaaa cttttctcgc aactggggtg tattgataga agagaaggga     2100

gatttggggg aggaaaaaaa ccaggaaaaa tgtttgatat ttaaggataa aacagatttt     2160

gctaaagcta aagaagtaga aatttttaaa aataatattt ggcgtatcag aacctctaag     2220

taccaaatcc aatttttgaa taggcttttt aagaaaacca aagaatggga tttaatgaat     2280

cttgtattga gcgagcctag cttagtattg gaggaggaat ggggtgtttc gtgggataaa     2340

gataaacttt tacctttact gaagaaagaa aaatcttgcg aagaaagatt atattactca     2400

cttcccctta acttggtgcc tgccacagat tataaggagc aatctgcaga aatagagcaa     2460

aggaatacat atttgggttt ggatgttgga gaatttggtg ttgcctatgc agtggtaaga     2520

atagtaaggg acagaataga gcttctgtcc tggggattcc ttaaggaccc agctcttcga     2580

aaaataagag agcgtgtaca ggatatgaag aaaaagcagg taatggcagt attttctagc     2640

tcttccacag ctgtcgcgcg agtacgagaa atggctatac actctttaag aaatcaaatt     2700

catagcattg ctttggcgta taaagcaaag ataatttatg agatatctat aagcaatttt     2760

gagacaggtg gtaatagaat ggctaaaata taccgatcta taaaggtttc agatgtttat     2820

agggagagtg gtgcggatac cctagtttca gagatgatct ggggcaaaaa gaataagcaa     2880

atgggaaacc atatatcttc ctatgcgaca agttacactt gttgcaattg tgcaagaacc     2940

ccttttgaac ttgttataga taatgacaag gaatatgaaa agggaggcga cgaatttatt     3000

tttaatgttg gcgatgaaaa gaaggtaagg gggtttttac aaaagagtct gttaggaaaa     3060

acaattaaag ggaaggaagt gttgaagtct ataaaagagt acgcaaggcc gcctataagg     3120

gaagtcttgc ttgaaggaga agatgtagag cagttgttga agaggagagg aaatagctat     3180

atttatagat gccctttttg tggatataaa actgatgcgg atattcaagc ggcgttgaat     3240

atagcttgta ggggatatat ttcggataac gcaaaggatg ctgtgaagga aggagaaaga     3300

aaattagatt acattttgga agttagaaaa ttgtgggaga agaatggagc tgttttgaga     3360

agcgccaaat ttttatagtt                                                 3380


<210>  11
<211>  1226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasY.2

<400>  11

Met Gln Lys Val Arg Lys Thr Leu Ser Glu Val His Lys Asn Pro Tyr 
1               5                   10                  15      


Gly Thr Lys Val Arg Asn Ala Lys Thr Gly Tyr Ser Leu Gln Ile Glu 
            20                  25                  30          


Arg Leu Ser Tyr Thr Gly Lys Glu Gly Met Arg Ser Phe Lys Ile Pro 
        35                  40                  45              


Leu Glu Asn Lys Asn Lys Glu Val Phe Asp Glu Phe Val Lys Lys Ile 
    50                  55                  60                  


Arg Asn Asp Tyr Ile Ser Gln Val Gly Leu Leu Asn Leu Ser Asp Trp 
65                  70                  75                  80  


Tyr Glu His Tyr Gln Glu Lys Gln Glu His Tyr Ser Leu Ala Asp Phe 
                85                  90                  95      


Trp Leu Asp Ser Leu Arg Ala Gly Val Ile Phe Ala His Lys Glu Thr 
            100                 105                 110         


Glu Ile Lys Asn Leu Ile Ser Lys Ile Arg Gly Asp Lys Ser Ile Val 
        115                 120                 125             


Asp Lys Phe Asn Ala Ser Ile Lys Lys Lys His Ala Asp Leu Tyr Ala 
    130                 135                 140                 


Leu Val Asp Ile Lys Ala Leu Tyr Asp Phe Leu Thr Ser Asp Ala Arg 
145                 150                 155                 160 


Arg Gly Leu Lys Thr Glu Glu Glu Phe Phe Asn Ser Lys Arg Asn Thr 
                165                 170                 175     


Leu Phe Pro Lys Phe Arg Lys Lys Asp Asn Lys Ala Val Asp Leu Trp 
            180                 185                 190         


Val Lys Lys Phe Ile Gly Leu Asp Asn Lys Asp Lys Leu Asn Phe Thr 
        195                 200                 205             


Lys Lys Phe Ile Gly Phe Asp Pro Asn Pro Gln Ile Lys Tyr Asp His 
    210                 215                 220                 


Thr Phe Phe Phe His Gln Asp Ile Asn Phe Asp Leu Glu Arg Ile Thr 
225                 230                 235                 240 


Thr Pro Lys Glu Leu Ile Ser Thr Tyr Lys Lys Phe Leu Gly Lys Asn 
                245                 250                 255     


Lys Asp Leu Tyr Gly Ser Asp Glu Thr Thr Glu Asp Gln Leu Lys Met 
            260                 265                 270         


Val Leu Gly Phe His Asn Asn His Gly Ala Phe Ser Lys Tyr Phe Asn 
        275                 280                 285             


Ala Ser Leu Glu Ala Phe Arg Gly Arg Asp Asn Ser Leu Val Glu Gln 
    290                 295                 300                 


Ile Ile Asn Asn Ser Pro Tyr Trp Asn Ser His Arg Lys Glu Leu Glu 
305                 310                 315                 320 


Lys Arg Ile Ile Phe Leu Gln Val Gln Ser Lys Lys Ile Lys Glu Thr 
                325                 330                 335     


Glu Leu Gly Lys Pro His Glu Tyr Leu Ala Ser Phe Gly Gly Lys Phe 
            340                 345                 350         


Glu Ser Trp Val Ser Asn Tyr Leu Arg Gln Glu Glu Glu Val Lys Arg 
        355                 360                 365             


Gln Leu Phe Gly Tyr Glu Glu Asn Lys Lys Gly Gln Lys Lys Phe Ile 
    370                 375                 380                 


Val Gly Asn Lys Gln Glu Leu Asp Lys Ile Ile Arg Gly Thr Asp Glu 
385                 390                 395                 400 


Tyr Glu Ile Lys Ala Ile Ser Lys Glu Thr Ile Gly Leu Thr Gln Lys 
                405                 410                 415     


Cys Leu Lys Leu Leu Glu Gln Leu Lys Asp Ser Val Asp Asp Tyr Thr 
            420                 425                 430         


Leu Ser Leu Tyr Arg Gln Leu Ile Val Glu Leu Arg Ile Arg Leu Asn 
        435                 440                 445             


Val Glu Phe Gln Glu Thr Tyr Pro Glu Leu Ile Gly Lys Ser Glu Lys 
    450                 455                 460                 


Asp Lys Glu Lys Asp Ala Lys Asn Lys Arg Ala Asp Lys Arg Tyr Pro 
465                 470                 475                 480 


Gln Ile Phe Lys Asp Ile Lys Leu Ile Pro Asn Phe Leu Gly Glu Thr 
                485                 490                 495     


Lys Gln Met Val Tyr Lys Lys Phe Ile Arg Ser Ala Asp Ile Leu Tyr 
            500                 505                 510         


Glu Gly Ile Asn Phe Ile Asp Gln Ile Asp Lys Gln Ile Thr Gln Asn 
        515                 520                 525             


Leu Leu Pro Cys Phe Lys Asn Asp Lys Glu Arg Ile Glu Phe Thr Glu 
    530                 535                 540                 


Lys Gln Phe Glu Thr Leu Arg Arg Lys Tyr Tyr Leu Met Asn Ser Ser 
545                 550                 555                 560 


Arg Phe His His Val Ile Glu Gly Ile Ile Asn Asn Arg Lys Leu Ile 
                565                 570                 575     


Glu Met Lys Lys Arg Glu Asn Ser Glu Leu Lys Thr Phe Ser Asp Ser 
            580                 585                 590         


Lys Phe Val Leu Ser Lys Leu Phe Leu Lys Lys Gly Lys Lys Tyr Glu 
        595                 600                 605             


Asn Glu Val Tyr Tyr Thr Phe Tyr Ile Asn Pro Lys Ala Arg Asp Gln 
    610                 615                 620                 


Arg Arg Ile Lys Ile Val Leu Asp Ile Asn Gly Asn Asn Ser Val Gly 
625                 630                 635                 640 


Ile Leu Gln Asp Leu Val Gln Lys Leu Lys Pro Lys Trp Asp Asp Ile 
                645                 650                 655     


Ile Lys Lys Asn Asp Met Gly Glu Leu Ile Asp Ala Ile Glu Ile Glu 
            660                 665                 670         


Lys Val Arg Leu Gly Ile Leu Ile Ala Leu Tyr Cys Glu His Lys Phe 
        675                 680                 685             


Lys Ile Lys Lys Glu Leu Leu Ser Leu Asp Leu Phe Ala Ser Ala Tyr 
    690                 695                 700                 


Gln Tyr Leu Glu Leu Glu Asp Asp Pro Glu Glu Leu Ser Gly Thr Asn 
705                 710                 715                 720 


Leu Gly Arg Phe Leu Gln Ser Leu Val Cys Ser Glu Ile Lys Gly Ala 
                725                 730                 735     


Ile Asn Lys Ile Ser Arg Thr Glu Tyr Ile Glu Arg Tyr Thr Val Gln 
            740                 745                 750         


Pro Met Asn Thr Glu Lys Asn Tyr Pro Leu Leu Ile Asn Lys Glu Gly 
        755                 760                 765             


Lys Ala Thr Trp His Ile Ala Ala Lys Asp Asp Leu Ser Lys Lys Lys 
    770                 775                 780                 


Gly Gly Gly Thr Val Ala Met Asn Gln Lys Ile Gly Lys Asn Phe Phe 
785                 790                 795                 800 


Gly Lys Gln Asp Tyr Lys Thr Val Phe Met Leu Gln Asp Lys Arg Phe 
                805                 810                 815     


Asp Leu Leu Thr Ser Lys Tyr His Leu Gln Phe Leu Ser Lys Thr Leu 
            820                 825                 830         


Asp Thr Gly Gly Gly Ser Trp Trp Lys Asn Lys Asn Ile Asp Leu Asn 
        835                 840                 845             


Leu Ser Ser Tyr Ser Phe Ile Phe Glu Gln Lys Val Lys Val Glu Trp 
    850                 855                 860                 


Asp Leu Thr Asn Leu Asp His Pro Ile Lys Ile Lys Pro Ser Glu Asn 
865                 870                 875                 880 


Ser Asp Asp Arg Arg Leu Phe Val Ser Ile Pro Phe Val Ile Lys Pro 
                885                 890                 895     


Lys Gln Thr Lys Arg Lys Asp Leu Gln Thr Arg Val Asn Tyr Met Gly 
            900                 905                 910         


Ile Asp Ile Gly Glu Tyr Gly Leu Ala Trp Thr Ile Ile Asn Ile Asp 
        915                 920                 925             


Leu Lys Asn Lys Lys Ile Asn Lys Ile Ser Lys Gln Gly Phe Ile Tyr 
    930                 935                 940                 


Glu Pro Leu Thr His Lys Val Arg Asp Tyr Val Ala Thr Ile Lys Asp 
945                 950                 955                 960 


Asn Gln Val Arg Gly Thr Phe Gly Met Pro Asp Thr Lys Leu Ala Arg 
                965                 970                 975     


Leu Arg Glu Asn Ala Ile Thr Ser Leu Arg Asn Gln Val His Asp Ile 
            980                 985                 990         


Ala Met Arg Tyr Asp Ala Lys Pro  Val Tyr Glu Phe Glu  Ile Ser Asn 
        995                 1000                 1005             


Phe Glu  Thr Gly Ser Asn Lys  Val Lys Val Ile Tyr  Asp Ser Val 
    1010                 1015                 1020             


Lys Arg  Ala Asp Ile Gly Arg  Gly Gln Asn Asn Thr  Glu Ala Asp 
    1025                 1030                 1035             


Asn Thr  Glu Val Asn Leu Val  Trp Gly Lys Thr Ser  Lys Gln Phe 
    1040                 1045                 1050             


Gly Ser  Gln Ile Gly Ala Tyr  Ala Thr Ser Tyr Ile  Cys Ser Phe 
    1055                 1060                 1065             


Cys Gly  Tyr Ser Pro Tyr Tyr  Glu Phe Glu Asn Ser  Lys Ser Gly 
    1070                 1075                 1080             


Asp Glu  Glu Gly Ala Arg Asp  Asn Leu Tyr Gln Met  Lys Lys Leu 
    1085                 1090                 1095             


Ser Arg  Pro Ser Leu Glu Asp  Phe Leu Gln Gly Asn  Pro Val Tyr 
    1100                 1105                 1110             


Lys Thr  Phe Arg Asp Phe Asp  Lys Tyr Lys Asn Asp  Gln Arg Leu 
    1115                 1120                 1125             


Gln Lys  Thr Gly Asp Lys Asp  Gly Glu Trp Lys Thr  His Arg Gly 
    1130                 1135                 1140             


Asn Thr  Ala Ile Tyr Ala Cys  Gln Lys Cys Arg His  Ile Ser Asp 
    1145                 1150                 1155             


Ala Asp  Ile Gln Ala Ser Tyr  Trp Ile Ala Leu Lys  Gln Val Val 
    1160                 1165                 1170             


Arg Asp  Phe Tyr Lys Asp Lys  Glu Met Asp Gly Asp  Leu Ile Gln 
    1175                 1180                 1185             


Gly Asp  Asn Lys Asp Lys Arg  Lys Val Asn Glu Leu  Asn Arg Leu 
    1190                 1195                 1200             


Ile Gly  Val His Lys Asp Val  Pro Ile Ile Asn Lys  Asn Leu Ile 
    1205                 1210                 1215             


Thr Ser  Leu Asp Ile Asn Leu  Leu 
    1220                 1225     


<210>  12
<211>  2869
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasY.2

<400>  12
atggtattag gttttcataa taatcacggc gctttttcta agtatttcaa cgcgagcttg       60

gaagctttta gggggagaga caactccttg gttgaacaaa taattaataa ttctccttac      120

tggaatagcc atcggaaaga attggaaaag agaatcattt ttttgcaagt tcagtctaaa      180

aaaataaaag agaccgaact gggaaagcct cacgagtatc ttgcgagttt tggcgggaag      240

tttgaatctt gggtttcaaa ctatttacgt caggaagaag aggtcaaacg tcaacttttt      300

ggttatgagg agaataaaaa aggccagaaa aaatttatcg tgggcaacaa acaagagcta      360

gataaaatca tcagagggac agatgagtat gagattaaag cgatttctaa ggaaaccatt      420

ggacttactc agaaatgttt aaaattactt gaacaactaa aagatagtgt cgatgattat      480

acacttagcc tatatcggca actcatagtc gaattgagaa tcagactgaa tgttgaattc      540

caagaaactt atccggaatt aatcggtaag agtgagaaag ataaagaaaa agatgcgaaa      600

aataaacggg cagacaagcg ttacccgcaa atttttaagg atataaaatt aatccccaat      660

tttctcggtg aaacgaaaca aatggtatat aagaaattta ttcgttccgc tgacatcctt      720

tatgaaggaa taaattttat cgaccagatc gataaacaga ttactcaaaa tttgttgcct      780

tgttttaaga acgacaagga acggattgaa tttaccgaaa aacaatttga aactttacgg      840

cgaaaatact atctgatgaa tagttcccgt tttcaccatg ttattgaagg aataatcaat      900

aataggaaac ttattgaaat gaaaaagaga gaaaatagcg agttgaaaac tttctccgat      960

agtaagtttg ttttatctaa gctttttctt aaaaaaggca aaaaatatga aaatgaggtc     1020

tattatactt tttatataaa tccgaaagct cgtgaccagc gacggataaa aattgttctt     1080

gatataaatg ggaacaattc agtcggaatt ttacaagatc ttgtccaaaa gttgaaacca     1140

aaatgggacg acatcataaa gaaaaatgat atgggagaat taatcgatgc aatcgagatt     1200

gagaaagtcc ggctcggcat cttgatagcg ttatactgtg agcataaatt caaaattaaa     1260

aaagaactct tgtcattaga tttgtttgcc agtgcctatc aatatctaga attggaagat     1320

gaccctgaag aactttctgg gacaaaccta ggtcggtttt tacaatcctt ggtctgctcc     1380

gaaattaaag gtgcgattaa taaaataagc aggacagaat atatagagcg gtatactgtc     1440

cagccgatga atacggagaa aaactatcct ttactcatca ataaggaggg aaaagccact     1500

tggcatattg ctgctaagga tgacttgtcc aagaagaagg gtgggggcac tgtcgctatg     1560

aatcaaaaaa tcggcaagaa tttttttggg aaacaagatt ataaaactgt gtttatgctt     1620

caggataagc ggtttgatct actaacctca aagtatcact tgcagttttt atctaaaact     1680

cttgatactg gtggagggtc ttggtggaaa aacaaaaata ttgatttaaa tttaagctct     1740

tattctttca ttttcgaaca aaaagtaaaa gtcgaatggg atttaaccaa tcttgaccat     1800

cctataaaga ttaagcctag cgagaacagt gatgatagaa ggcttttcgt atccattcct     1860

tttgttatta aaccgaaaca gacaaaaaga aaggatttgc aaactcgagt caattatatg     1920

gggattgata tcggagaata tggtttggct tggacaatta ttaatattga tttaaagaat     1980

aaaaaaataa ataagatttc aaaacaaggt ttcatctatg agccgttgac acataaagtg     2040

cgcgattatg ttgctaccat taaagataat caggttagag gaacttttgg catgcctgat     2100

acgaaactag ccagattgcg agaaaatgcc attaccagct tgcgcaatca agtgcatgat     2160

attgctatgc gctatgacgc caaaccggta tatgaatttg aaatttccaa ttttgaaacg     2220

gggtctaata aagtgaaagt aatttatgat tcggttaagc gagctgatat cggccgaggc     2280

cagaataata ccgaagcaga caatactgag gttaatcttg tctgggggaa gacaagcaaa     2340

caatttggca gtcaaatcgg cgcttatgcg acaagttaca tctgttcatt ttgtggttat     2400

tctccatatt atgaatttga aaattctaag tcgggagatg aagaaggggc tagagataat     2460

ctatatcaga tgaagaaatt gagtcgcccc tctcttgaag atttcctcca aggaaatccg     2520

gtttataaga catttaggga ttttgataag tataaaaacg atcaacggtt gcaaaagacg     2580

ggtgataaag atggtgaatg gaaaacacac agagggaata ctgcaatata cgcctgtcaa     2640

aagtgtagac atatctctga tgcggatatc caagcatcat attggattgc tttgaagcaa     2700

gttgtaagag atttttataa agacaaagag atggatggtg atttgattca aggagataat     2760

aaagacaaga gaaaagtaaa cgagcttaat agacttattg gagtacataa agatgtgcct     2820

ataataaata aaaatttaat aacatcactc gacataaact tactataga                 2869


<210>  13
<211>  1200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasY.3

<400>  13

Met Lys Ala Lys Lys Ser Phe Tyr Asn Gln Lys Arg Lys Phe Gly Lys 
1               5                   10                  15      


Arg Gly Tyr Arg Leu His Asp Glu Arg Ile Ala Tyr Ser Gly Gly Ile 
            20                  25                  30          


Gly Ser Met Arg Ser Ile Lys Tyr Glu Leu Lys Asp Ser Tyr Gly Ile 
        35                  40                  45              


Ala Gly Leu Arg Asn Arg Ile Ala Asp Ala Thr Ile Ser Asp Asn Lys 
    50                  55                  60                  


Trp Leu Tyr Gly Asn Ile Asn Leu Asn Asp Tyr Leu Glu Trp Arg Ser 
65                  70                  75                  80  


Ser Lys Thr Asp Lys Gln Ile Glu Asp Gly Asp Arg Glu Ser Ser Leu 
                85                  90                  95      


Leu Gly Phe Trp Leu Glu Ala Leu Arg Leu Gly Phe Val Phe Ser Lys 
            100                 105                 110         


Gln Ser His Ala Pro Asn Asp Phe Asn Glu Thr Ala Leu Gln Asp Leu 
        115                 120                 125             


Phe Glu Thr Leu Asp Asp Asp Leu Lys His Val Leu Asp Arg Lys Lys 
    130                 135                 140                 


Trp Cys Asp Phe Ile Lys Ile Gly Thr Pro Lys Thr Asn Asp Gln Gly 
145                 150                 155                 160 


Arg Leu Lys Lys Gln Ile Lys Asn Leu Leu Lys Gly Asn Lys Arg Glu 
                165                 170                 175     


Glu Ile Glu Lys Thr Leu Asn Glu Ser Asp Asp Glu Leu Lys Glu Lys 
            180                 185                 190         


Ile Asn Arg Ile Ala Asp Val Phe Ala Lys Asn Lys Ser Asp Lys Tyr 
        195                 200                 205             


Thr Ile Phe Lys Leu Asp Lys Pro Asn Thr Glu Lys Tyr Pro Arg Ile 
    210                 215                 220                 


Asn Asp Val Gln Val Ala Phe Phe Cys His Pro Asp Phe Glu Glu Ile 
225                 230                 235                 240 


Thr Glu Arg Asp Arg Thr Lys Thr Leu Asp Leu Ile Ile Asn Arg Phe 
                245                 250                 255     


Asn Lys Arg Tyr Glu Ile Thr Glu Asn Lys Lys Asp Asp Lys Thr Ser 
            260                 265                 270         


Asn Arg Met Ala Leu Tyr Ser Leu Asn Gln Gly Tyr Ile Pro Arg Val 
        275                 280                 285             


Leu Asn Asp Leu Phe Leu Phe Val Lys Asp Asn Glu Asp Asp Phe Ser 
    290                 295                 300                 


Gln Phe Leu Ser Asp Leu Glu Asn Phe Phe Ser Phe Ser Asn Glu Gln 
305                 310                 315                 320 


Ile Lys Ile Ile Lys Glu Arg Leu Lys Lys Leu Lys Lys Tyr Ala Glu 
                325                 330                 335     


Pro Ile Pro Gly Lys Pro Gln Leu Ala Asp Lys Trp Asp Asp Tyr Ala 
            340                 345                 350         


Ser Asp Phe Gly Gly Lys Leu Glu Ser Trp Tyr Ser Asn Arg Ile Glu 
        355                 360                 365             


Lys Leu Lys Lys Ile Pro Glu Ser Val Ser Asp Leu Arg Asn Asn Leu 
    370                 375                 380                 


Glu Lys Ile Arg Asn Val Leu Lys Lys Gln Asn Asn Ala Ser Lys Ile 
385                 390                 395                 400 


Leu Glu Leu Ser Gln Lys Ile Ile Glu Tyr Ile Arg Asp Tyr Gly Val 
                405                 410                 415     


Ser Phe Glu Lys Pro Glu Ile Ile Lys Phe Ser Trp Ile Asn Lys Thr 
            420                 425                 430         


Lys Asp Gly Gln Lys Lys Val Phe Tyr Val Ala Lys Met Ala Asp Arg 
        435                 440                 445             


Glu Phe Ile Glu Lys Leu Asp Leu Trp Met Ala Asp Leu Arg Ser Gln 
    450                 455                 460                 


Leu Asn Glu Tyr Asn Gln Asp Asn Lys Val Ser Phe Lys Lys Lys Gly 
465                 470                 475                 480 


Lys Lys Ile Glu Glu Leu Gly Val Leu Asp Phe Ala Leu Asn Lys Ala 
                485                 490                 495     


Lys Lys Asn Lys Ser Thr Lys Asn Glu Asn Gly Trp Gln Gln Lys Leu 
            500                 505                 510         


Ser Glu Ser Ile Gln Ser Ala Pro Leu Phe Phe Gly Glu Gly Asn Arg 
        515                 520                 525             


Val Arg Asn Glu Glu Val Tyr Asn Leu Lys Asp Leu Leu Phe Ser Glu 
    530                 535                 540                 


Ile Lys Asn Val Glu Asn Ile Leu Met Ser Ser Glu Ala Glu Asp Leu 
545                 550                 555                 560 


Lys Asn Ile Lys Ile Glu Tyr Lys Glu Asp Gly Ala Lys Lys Gly Asn 
                565                 570                 575     


Tyr Val Leu Asn Val Leu Ala Arg Phe Tyr Ala Arg Phe Asn Glu Asp 
            580                 585                 590         


Gly Tyr Gly Gly Trp Asn Lys Val Lys Thr Val Leu Glu Asn Ile Ala 
        595                 600                 605             


Arg Glu Ala Gly Thr Asp Phe Ser Lys Tyr Gly Asn Asn Asn Asn Arg 
    610                 615                 620                 


Asn Ala Gly Arg Phe Tyr Leu Asn Gly Arg Glu Arg Gln Val Phe Thr 
625                 630                 635                 640 


Leu Ile Lys Phe Glu Lys Ser Ile Thr Val Glu Lys Ile Leu Glu Leu 
                645                 650                 655     


Val Lys Leu Pro Ser Leu Leu Asp Glu Ala Tyr Arg Asp Leu Val Asn 
            660                 665                 670         


Glu Asn Lys Asn His Lys Leu Arg Asp Val Ile Gln Leu Ser Lys Thr 
        675                 680                 685             


Ile Met Ala Leu Val Leu Ser His Ser Asp Lys Glu Lys Gln Ile Gly 
    690                 695                 700                 


Gly Asn Tyr Ile His Ser Lys Leu Ser Gly Tyr Asn Ala Leu Ile Ser 
705                 710                 715                 720 


Lys Arg Asp Phe Ile Ser Arg Tyr Ser Val Gln Thr Thr Asn Gly Thr 
                725                 730                 735     


Gln Cys Lys Leu Ala Ile Gly Lys Gly Lys Ser Lys Lys Gly Asn Glu 
            740                 745                 750         


Ile Asp Arg Tyr Phe Tyr Ala Phe Gln Phe Phe Lys Asn Asp Asp Ser 
        755                 760                 765             


Lys Ile Asn Leu Lys Val Ile Lys Asn Asn Ser His Lys Asn Ile Asp 
    770                 775                 780                 


Phe Asn Asp Asn Glu Asn Lys Ile Asn Ala Leu Gln Val Tyr Ser Ser 
785                 790                 795                 800 


Asn Tyr Gln Ile Gln Phe Leu Asp Trp Phe Phe Glu Lys His Gln Gly 
                805                 810                 815     


Lys Lys Thr Ser Leu Glu Val Gly Gly Ser Phe Thr Ile Ala Glu Lys 
            820                 825                 830         


Ser Leu Thr Ile Asp Trp Ser Gly Ser Asn Pro Arg Val Gly Phe Lys 
        835                 840                 845             


Arg Ser Asp Thr Glu Glu Lys Arg Val Phe Val Ser Gln Pro Phe Thr 
    850                 855                 860                 


Leu Ile Pro Asp Asp Glu Asp Lys Glu Arg Arg Lys Glu Arg Met Ile 
865                 870                 875                 880 


Lys Thr Lys Asn Arg Phe Ile Gly Ile Asp Ile Gly Glu Tyr Gly Leu 
                885                 890                 895     


Ala Trp Ser Leu Ile Glu Val Asp Asn Gly Asp Lys Asn Asn Arg Gly 
            900                 905                 910         


Ile Arg Gln Leu Glu Ser Gly Phe Ile Thr Asp Asn Gln Gln Gln Val 
        915                 920                 925             


Leu Lys Lys Asn Val Lys Ser Trp Arg Gln Asn Gln Ile Arg Gln Thr 
    930                 935                 940                 


Phe Thr Ser Pro Asp Thr Lys Ile Ala Arg Leu Arg Glu Ser Leu Ile 
945                 950                 955                 960 


Gly Ser Tyr Lys Asn Gln Leu Glu Ser Leu Met Val Ala Lys Lys Ala 
                965                 970                 975     


Asn Leu Ser Phe Glu Tyr Glu Val Ser Gly Phe Glu Val Gly Gly Lys 
            980                 985                 990         


Arg Val Ala Lys Ile Tyr Asp Ser  Ile Lys Arg Gly Ser  Val Arg Lys 
        995                 1000                 1005             


Lys Asp  Asn Asn Ser Gln Asn  Asp Gln Ser Trp Gly  Lys Lys Gly 
    1010                 1015                 1020             


Ile Asn  Glu Trp Ser Phe Glu  Thr Thr Ala Ala Gly  Thr Ser Gln 
    1025                 1030                 1035             


Phe Cys  Thr His Cys Lys Arg  Trp Ser Ser Leu Ala  Ile Val Asp 
    1040                 1045                 1050             


Ile Glu  Glu Tyr Glu Leu Lys  Asp Tyr Asn Asp Asn  Leu Phe Lys 
    1055                 1060                 1065             


Val Lys  Ile Asn Asp Gly Glu  Val Arg Leu Leu Gly  Lys Lys Gly 
    1070                 1075                 1080             


Trp Arg  Ser Gly Glu Lys Ile  Lys Gly Lys Glu Leu  Phe Gly Pro 
    1085                 1090                 1095             


Val Lys  Asp Ala Met Arg Pro  Asn Val Asp Gly Leu  Gly Met Lys 
    1100                 1105                 1110             


Ile Val  Lys Arg Lys Tyr Leu  Lys Leu Asp Leu Arg  Asp Trp Val 
    1115                 1120                 1125             


Ser Arg  Tyr Gly Asn Met Ala  Ile Phe Ile Cys Pro  Tyr Val Asp 
    1130                 1135                 1140             


Cys His  His Ile Ser His Ala  Asp Lys Gln Ala Ala  Phe Asn Ile 
    1145                 1150                 1155             


Ala Val  Arg Gly Tyr Leu Lys  Ser Val Asn Pro Asp  Arg Ala Ile 
    1160                 1165                 1170             


Lys His  Gly Asp Lys Gly Leu  Ser Arg Asp Phe Leu  Cys Gln Glu 
    1175                 1180                 1185             


Glu Gly  Lys Leu Asn Phe Glu  Gln Ile Gly Leu Leu  
    1190                 1195                 1200 


<210>  14
<211>  3604
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasY.3

<400>  14
atgaaagcta aaaaaagttt ttataatcaa aagcggaagt tcggtaaaag aggttatcgt       60

cttcacgatg aacgtatcgc gtattcagga gggattggat cgatgcgatc tattaaatat      120

gaattgaagg attcgtatgg aattgctggg cttcgtaatc gaatcgctga cgcaactatt      180

tctgataata agtggctgta cgggaatata aatctaaatg attatttaga gtggcgatct      240

tcaaagactg acaaacagat tgaagacgga gaccgagaat catcactcct gggtttttgg      300

ctggaagcgt tacgactggg attcgtgttt tcaaaacaat ctcatgctcc gaatgatttt      360

aacgagaccg ctctacaaga tttgtttgaa actcttgatg atgatttgaa acatgttctt      420

gataggaaaa aatggtgtga ctttatcaag ataggaacac ctaagacaaa tgaccaaggt      480

cgtttaaaaa aacaaatcaa gaatttgtta aaaggaaaca agagagagga aattgaaaaa      540

actctcaatg aatcagacga tgaattgaaa gagaaaataa acagaattgc cgatgttttt      600

gcaaaaaata agtctgataa atacacaatt ttcaaattag ataaacccaa tacggaaaaa      660

taccccagaa tcaacgatgt tcaggtggcg tttttttgtc atcccgattt tgaggaaatt      720

acagaacgag atagaacaaa gactctagat ctgatcatta atcggtttaa taagagatat      780

gaaattaccg aaaataaaaa agatgacaaa acttcaaaca ggatggcctt gtattccttg      840

aaccagggct atattcctcg cgtcctgaat gatttattct tgtttgtcaa agacaatgag      900

gatgatttta gtcagttttt atctgatttg gagaatttct tctctttttc caacgaacaa      960

attaaaataa taaaggaaag gttaaaaaaa cttaaaaaat atgctgaacc aattcccgga     1020

aagccgcaac ttgctgataa atgggacgat tatgcttctg attttggcgg taaattggaa     1080

agctggtact ccaatcgaat agagaaatta aagaagattc cggaaagcgt ttccgatctg     1140

cggaataatt tggaaaagat acgcaatgtt ttaaaaaaac aaaataatgc atctaaaatc     1200

ctggagttat ctcaaaagat cattgaatac atcagagatt atggagtttc ttttgaaaag     1260

ccggagataa ttaagttcag ctggataaat aagacgaagg atggtcagaa aaaagttttc     1320

tatgttgcga aaatggcgga tagagaattc atagaaaagc ttgatttatg gatggctgat     1380

ttacgcagtc aattaaatga atacaatcaa gataataaag tttctttcaa aaagaaaggt     1440

aaaaaaatag aagagctcgg tgtcttggat tttgctctta ataaagcgaa aaaaaataaa     1500

agtacaaaaa atgaaaatgg ctggcaacaa aaattgtcag aatctattca atctgccccg     1560

ttattttttg gcgaagggaa tcgtgtacga aatgaagaag tttataattt gaaggacctt     1620

ctgttttcag aaatcaagaa tgttgaaaat attttaatga gctcggaagc ggaagactta     1680

aaaaatataa aaattgaata taaagaagat ggcgcgaaaa aagggaacta tgtcttgaat     1740

gtcttggcta gattttacgc gagattcaat gaggatggct atggtggttg gaacaaagta     1800

aaaaccgttt tggaaaatat tgcccgagag gcggggactg atttttcaaa atatggaaat     1860

aataacaata gaaatgccgg cagattttat ctaaacggcc gcgaacgaca agtttttact     1920

ctaatcaagt ttgaaaaaag tatcacggtg gaaaaaatac ttgaattggt aaaattacct     1980

agcctacttg atgaagcgta tagagattta gtcaacgaaa ataaaaatca taaattacgc     2040

gacgtaattc aattgagcaa gacaattatg gctctggttt tatctcattc tgataaagaa     2100

aaacaaattg gaggaaatta tatccatagt aaattgagcg gatacaatgc gcttatttca     2160

aagcgagatt ttatctcgcg gtatagcgtg caaacgacca acggaactca atgtaaatta     2220

gccataggaa aaggcaaaag caaaaaaggt aatgaaattg acaggtattt ctacgctttt     2280

caatttttta agaatgacga cagcaaaatt aatttaaagg taatcaaaaa taattcgcat     2340

aaaaacatcg atttcaacga caatgaaaat aaaattaacg cattgcaagt gtattcatca     2400

aactatcaga ttcaattctt agactggttt tttgaaaaac atcaagggaa gaaaacatcg     2460

ctcgaggtcg gcggatcttt taccatcgcc gaaaagagtt tgacaataga ctggtcgggg     2520

agtaatccga gagtcggttt taaaagaagc gacacggaag aaaagagggt ttttgtctcg     2580

caaccattta cattaatacc agacgatgaa gacaaagagc gtcgtaaaga aagaatgata     2640

aagacgaaaa accgttttat cggtatcgat atcggtgaat atggtctggc ttggagtcta     2700

atcgaagtgg acaatggaga taaaaataat agaggaatta gacaacttga gagcggtttt     2760

attacagaca atcagcagca agtcttaaag aaaaacgtaa aatcctggag gcaaaaccaa     2820

attcgtcaaa cgtttacttc accagacaca aaaattgctc gtcttcgtga aagtttgatc     2880

ggaagttaca aaaatcaact ggaaagtctg atggttgcta aaaaagcaaa tcttagtttt     2940

gaatacgaag tttccgggtt tgaagttggg ggaaagaggg ttgcaaaaat atacgatagt     3000

ataaagcgtg ggtcggtgcg taaaaaggat aataactcac aaaatgatca aagttggggt     3060

aaaaagggaa ttaatgagtg gtcattcgag acgacggctg ccggaacatc gcaattttgt     3120

actcattgca agcggtggag cagtttagcg atagtagata ttgaagaata tgaattaaaa     3180

gattacaacg ataatttatt taaggtaaaa attaatgatg gtgaagttcg tctccttggt     3240

aagaaaggtt ggagatccgg cgaaaagatc aaagggaaag aattatttgg tcccgtcaaa     3300

gacgcaatgc gcccaaatgt tgacggacta gggatgaaaa ttgtaaaaag aaaatatcta     3360

aaacttgatc tccgcgattg ggtttcaaga tatgggaata tggctatttt catctgtcct     3420

tatgtcgatt gccaccatat ctctcatgcg gataaacaag ctgcttttaa tattgccgtg     3480

cgagggtatt tgaaaagcgt taatcctgac agagcaataa aacacggaga taaaggtttg     3540

tctagggact ttttgtgcca agaagagggt aagcttaatt ttgaacaaat agggttatta     3600

tgaa                                                                  3604


<210>  15
<211>  1210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasY.4

<400>  15

Met Ser Lys Arg His Pro Arg Ile Ser Gly Val Lys Gly Tyr Arg Leu 
1               5                   10                  15      


His Ala Gln Arg Leu Glu Tyr Thr Gly Lys Ser Gly Ala Met Arg Thr 
            20                  25                  30          


Ile Lys Tyr Pro Leu Tyr Ser Ser Pro Ser Gly Gly Arg Thr Val Pro 
        35                  40                  45              


Arg Glu Ile Val Ser Ala Ile Asn Asp Asp Tyr Val Gly Leu Tyr Gly 
    50                  55                  60                  


Leu Ser Asn Phe Asp Asp Leu Tyr Asn Ala Glu Lys Arg Asn Glu Glu 
65                  70                  75                  80  


Lys Val Tyr Ser Val Leu Asp Phe Trp Tyr Asp Cys Val Gln Tyr Gly 
                85                  90                  95      


Ala Val Phe Ser Tyr Thr Ala Pro Gly Leu Leu Lys Asn Val Ala Glu 
            100                 105                 110         


Val Arg Gly Gly Ser Tyr Glu Leu Thr Lys Thr Leu Lys Gly Ser His 
        115                 120                 125             


Leu Tyr Asp Glu Leu Gln Ile Asp Lys Val Ile Lys Phe Leu Asn Lys 
    130                 135                 140                 


Lys Glu Ile Ser Arg Ala Asn Gly Ser Leu Asp Lys Leu Lys Lys Asp 
145                 150                 155                 160 


Ile Ile Asp Cys Phe Lys Ala Glu Tyr Arg Glu Arg His Lys Asp Gln 
                165                 170                 175     


Cys Asn Lys Leu Ala Asp Asp Ile Lys Asn Ala Lys Lys Asp Ala Gly 
            180                 185                 190         


Ala Ser Leu Gly Glu Arg Gln Lys Lys Leu Phe Arg Asp Phe Phe Gly 
        195                 200                 205             


Ile Ser Glu Gln Ser Glu Asn Asp Lys Pro Ser Phe Thr Asn Pro Leu 
    210                 215                 220                 


Asn Leu Thr Cys Cys Leu Leu Pro Phe Asp Thr Val Asn Asn Asn Arg 
225                 230                 235                 240 


Asn Arg Gly Glu Val Leu Phe Asn Lys Leu Lys Glu Tyr Ala Gln Lys 
                245                 250                 255     


Leu Asp Lys Asn Glu Gly Ser Leu Glu Met Trp Glu Tyr Ile Gly Ile 
            260                 265                 270         


Gly Asn Ser Gly Thr Ala Phe Ser Asn Phe Leu Gly Glu Gly Phe Leu 
        275                 280                 285             


Gly Arg Leu Arg Glu Asn Lys Ile Thr Glu Leu Lys Lys Ala Met Met 
    290                 295                 300                 


Asp Ile Thr Asp Ala Trp Arg Gly Gln Glu Gln Glu Glu Glu Leu Glu 
305                 310                 315                 320 


Lys Arg Leu Arg Ile Leu Ala Ala Leu Thr Ile Lys Leu Arg Glu Pro 
                325                 330                 335     


Lys Phe Asp Asn His Trp Gly Gly Tyr Arg Ser Asp Ile Asn Gly Lys 
            340                 345                 350         


Leu Ser Ser Trp Leu Gln Asn Tyr Ile Asn Gln Thr Val Lys Ile Lys 
        355                 360                 365             


Glu Asp Leu Lys Gly His Lys Lys Asp Leu Lys Lys Ala Lys Glu Met 
    370                 375                 380                 


Ile Asn Arg Phe Gly Glu Ser Asp Thr Lys Glu Glu Ala Val Val Ser 
385                 390                 395                 400 


Ser Leu Leu Glu Ser Ile Glu Lys Ile Val Pro Asp Asp Ser Ala Asp 
                405                 410                 415     


Asp Glu Lys Pro Asp Ile Pro Ala Ile Ala Ile Tyr Arg Arg Phe Leu 
            420                 425                 430         


Ser Asp Gly Arg Leu Thr Leu Asn Arg Phe Val Gln Arg Glu Asp Val 
        435                 440                 445             


Gln Glu Ala Leu Ile Lys Glu Arg Leu Glu Ala Glu Lys Lys Lys Lys 
    450                 455                 460                 


Pro Lys Lys Arg Lys Lys Lys Ser Asp Ala Glu Asp Glu Lys Glu Thr 
465                 470                 475                 480 


Ile Asp Phe Lys Glu Leu Phe Pro His Leu Ala Lys Pro Leu Lys Leu 
                485                 490                 495     


Val Pro Asn Phe Tyr Gly Asp Ser Lys Arg Glu Leu Tyr Lys Lys Tyr 
            500                 505                 510         


Lys Asn Ala Ala Ile Tyr Thr Asp Ala Leu Trp Lys Ala Val Glu Lys 
        515                 520                 525             


Ile Tyr Lys Ser Ala Phe Ser Ser Ser Leu Lys Asn Ser Phe Phe Asp 
    530                 535                 540                 


Thr Asp Phe Asp Lys Asp Phe Phe Ile Lys Arg Leu Gln Lys Ile Phe 
545                 550                 555                 560 


Ser Val Tyr Arg Arg Phe Asn Thr Asp Lys Trp Lys Pro Ile Val Lys 
                565                 570                 575     


Asn Ser Phe Ala Pro Tyr Cys Asp Ile Val Ser Leu Ala Glu Asn Glu 
            580                 585                 590         


Val Leu Tyr Lys Pro Lys Gln Ser Arg Ser Arg Lys Ser Ala Ala Ile 
        595                 600                 605             


Asp Lys Asn Arg Val Arg Leu Pro Ser Thr Glu Asn Ile Ala Lys Ala 
    610                 615                 620                 


Gly Ile Ala Leu Ala Arg Glu Leu Ser Val Ala Gly Phe Asp Trp Lys 
625                 630                 635                 640 


Asp Leu Leu Lys Lys Glu Glu His Glu Glu Tyr Ile Asp Leu Ile Glu 
                645                 650                 655     


Leu His Lys Thr Ala Leu Ala Leu Leu Leu Ala Val Thr Glu Thr Gln 
            660                 665                 670         


Leu Asp Ile Ser Ala Leu Asp Phe Val Glu Asn Gly Thr Val Lys Asp 
        675                 680                 685             


Phe Met Lys Thr Arg Asp Gly Asn Leu Val Leu Glu Gly Arg Phe Leu 
    690                 695                 700                 


Glu Met Phe Ser Gln Ser Ile Val Phe Ser Glu Leu Arg Gly Leu Ala 
705                 710                 715                 720 


Gly Leu Met Ser Arg Lys Glu Phe Ile Thr Arg Ser Ala Ile Gln Thr 
                725                 730                 735     


Met Asn Gly Lys Gln Ala Glu Leu Leu Tyr Ile Pro His Glu Phe Gln 
            740                 745                 750         


Ser Ala Lys Ile Thr Thr Pro Lys Glu Met Ser Arg Ala Phe Leu Asp 
        755                 760                 765             


Leu Ala Pro Ala Glu Phe Ala Thr Ser Leu Glu Pro Glu Ser Leu Ser 
    770                 775                 780                 


Glu Lys Ser Leu Leu Lys Leu Lys Gln Met Arg Tyr Tyr Pro His Tyr 
785                 790                 795                 800 


Phe Gly Tyr Glu Leu Thr Arg Thr Gly Gln Gly Ile Asp Gly Gly Val 
                805                 810                 815     


Ala Glu Asn Ala Leu Arg Leu Glu Lys Ser Pro Val Lys Lys Arg Glu 
            820                 825                 830         


Ile Lys Cys Lys Gln Tyr Lys Thr Leu Gly Arg Gly Gln Asn Lys Ile 
        835                 840                 845             


Val Leu Tyr Val Arg Ser Ser Tyr Tyr Gln Thr Gln Phe Leu Glu Trp 
    850                 855                 860                 


Phe Leu His Arg Pro Lys Asn Val Gln Thr Asp Val Ala Val Ser Gly 
865                 870                 875                 880 


Ser Phe Leu Ile Asp Glu Lys Lys Val Lys Thr Arg Trp Asn Tyr Asp 
                885                 890                 895     


Ala Leu Thr Val Ala Leu Glu Pro Val Ser Gly Ser Glu Arg Val Phe 
            900                 905                 910         


Val Ser Gln Pro Phe Thr Ile Phe Pro Glu Lys Ser Ala Glu Glu Glu 
        915                 920                 925             


Gly Gln Arg Tyr Leu Gly Ile Asp Ile Gly Glu Tyr Gly Ile Ala Tyr 
    930                 935                 940                 


Thr Ala Leu Glu Ile Thr Gly Asp Ser Ala Lys Ile Leu Asp Gln Asn 
945                 950                 955                 960 


Phe Ile Ser Asp Pro Gln Leu Lys Thr Leu Arg Glu Glu Val Lys Gly 
                965                 970                 975     


Leu Lys Leu Asp Gln Arg Arg Gly Thr Phe Ala Met Pro Ser Thr Lys 
            980                 985                 990         


Ile Ala Arg Ile Arg Glu Ser Leu  Val His Ser Leu Arg  Asn Arg Ile 
        995                 1000                 1005             


His His  Leu Ala Leu Lys His  Lys Ala Lys Ile Val  Tyr Glu Leu 
    1010                 1015                 1020             


Glu Val  Ser Arg Phe Glu Glu  Gly Lys Gln Lys Ile  Lys Lys Val 
    1025                 1030                 1035             


Tyr Ala  Thr Leu Lys Lys Ala  Asp Val Tyr Ser Glu  Ile Asp Ala 
    1040                 1045                 1050             


Asp Lys  Asn Leu Gln Thr Thr  Val Trp Gly Lys Leu  Ala Val Ala 
    1055                 1060                 1065             


Ser Glu  Ile Ser Ala Ser Tyr  Thr Ser Gln Phe Cys  Gly Ala Cys 
    1070                 1075                 1080             


Lys Lys  Leu Trp Arg Ala Glu  Met Gln Val Asp Glu  Thr Ile Thr 
    1085                 1090                 1095             


Thr Gln  Glu Leu Ile Gly Thr  Val Arg Val Ile Lys  Gly Gly Thr 
    1100                 1105                 1110             


Leu Ile  Asp Ala Ile Lys Asp  Phe Met Arg Pro Pro  Ile Phe Asp 
    1115                 1120                 1125             


Glu Asn  Asp Thr Pro Phe Pro  Lys Tyr Arg Asp Phe  Cys Asp Lys 
    1130                 1135                 1140             


His His  Ile Ser Lys Lys Met  Arg Gly Asn Ser Cys  Leu Phe Ile 
    1145                 1150                 1155             


Cys Pro  Phe Cys Arg Ala Asn  Ala Asp Ala Asp Ile  Gln Ala Ser 
    1160                 1165                 1170             


Gln Thr  Ile Ala Leu Leu Arg  Tyr Val Lys Glu Glu  Lys Lys Val 
    1175                 1180                 1185             


Glu Asp  Tyr Phe Glu Arg Phe  Arg Lys Leu Lys Asn  Ile Lys Val 
    1190                 1195                 1200             


Leu Gly  Gln Met Lys Lys Ile  
    1205                 1210 


<210>  16
<211>  3636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasY.4

<400>  16
atgagtaagc gacatcctag aattagcggc gtaaaagggt accgtttgca tgcgcaacgg       60

ctggaatata ccggcaaaag tggggcaatg cgaacgatta aatatcctct ttattcatct      120

ccgagcggtg gaagaacggt tccgcgcgag atagtttcag caatcaatga tgattatgta      180

gggctgtacg gtttgagtaa ttttgacgat ctgtataatg cggaaaagcg caacgaagaa      240

aaggtctact cggttttaga tttttggtac gactgcgtcc aatacggcgc ggttttttcg      300

tatacagcgc cgggtctttt gaaaaatgtt gccgaagttc gcgggggaag ctacgaactt      360

acaaaaacgc ttaaagggag ccatttatat gatgaattgc aaattgataa agtaattaaa      420

tttttgaata aaaaagaaat ttcgcgagca aacggatcgc ttgataaact gaagaaagac      480

atcattgatt gcttcaaagc agaatatcgg gaacgacata aagatcaatg caataaactg      540

gctgatgata ttaaaaatgc aaaaaaagac gcgggagctt ctttagggga gcgtcaaaaa      600

aaattatttc gcgatttttt tggaatttca gagcagtctg aaaatgataa accgtctttt      660

actaatccgc taaacttaac ctgctgttta ttgccttttg acacagtgaa taacaacaga      720

aaccgcggcg aagttttgtt taacaagctc aaggaatatg ctcaaaaatt ggataaaaac      780

gaagggtcgc ttgaaatgtg ggaatatatt ggcatcggga acagcggcac tgccttttct      840

aattttttag gagaagggtt tttgggcaga ttgcgcgaga ataaaattac agagctgaaa      900

aaagccatga tggatattac agatgcatgg cgtgggcagg aacaggaaga agagttagaa      960

aaacgtctgc ggatacttgc cgcgcttacc ataaaattgc gcgagccgaa atttgacaac     1020

cactggggag ggtatcgcag tgatataaac ggcaaattat ctagctggct tcagaattac     1080

ataaatcaaa cagtcaaaat caaagaggac ttaaagggac acaaaaagga cctgaaaaaa     1140

gcgaaagaga tgataaatag gtttggggaa agcgacacaa aggaagaggc ggttgtttca     1200

tctttgcttg aaagcattga aaaaattgtt cctgatgata gcgctgatga cgagaaaccc     1260

gatattccag ctattgctat ctatcgccgc tttctttcgg atggacgatt aacattgaat     1320

cgctttgtcc aaagagaaga tgtgcaagag gcgctgataa aagaaagatt ggaagcggag     1380

aaaaagaaaa aaccgaaaaa gcgaaaaaag aaaagtgacg ctgaagatga aaaagaaaca     1440

attgacttca aggagttatt tcctcatctt gccaaaccat taaaattggt gccaaacttt     1500

tacggcgaca gtaagcgtga gctgtacaag aaatataaga acgccgctat ttatacagat     1560

gctctgtgga aagcagtgga aaaaatatac aaaagcgcgt tctcgtcgtc tctaaaaaat     1620

tcattttttg atacagattt tgataaagat ttttttatta agcggcttca gaaaattttt     1680

tcggtttatc gtcggtttaa tacagacaaa tggaaaccga ttgtgaaaaa ctctttcgcg     1740

ccctattgcg acatcgtctc acttgcggag aatgaagttt tgtataaacc gaaacagtcg     1800

cgcagtagaa aatctgccgc gattgataaa aacagagtgc gtctcccttc cactgaaaat     1860

atcgcaaaag ctggcattgc cctcgcgcgg gagctttcag tcgcaggatt tgactggaaa     1920

gatttgttaa aaaaagagga gcatgaagaa tacattgatc tcatagaatt gcacaaaacc     1980

gcgcttgcgc ttcttcttgc cgtaacagaa acacagcttg acataagcgc gttggatttt     2040

gtagaaaatg ggacggtcaa ggattttatg aaaacgcggg acggcaatct ggttttggaa     2100

gggcgtttcc ttgaaatgtt ctcgcagtca attgtgtttt cagaattgcg cgggcttgcg     2160

ggtttaatga gccgcaagga atttatcact cgctccgcga ttcaaactat gaacggcaaa     2220

caggcggagc ttctctacat tccgcatgaa ttccaatcgg caaaaattac aacgccaaag     2280

gaaatgagca gggcgtttct tgaccttgcg cccgcggaat ttgctacatc gcttgagcca     2340

gaatcgcttt cggagaagtc attattgaaa ttgaagcaga tgcggtacta tccgcattat     2400

tttggatatg agcttacgcg aacaggacag gggattgatg gtggagtcgc ggaaaatgcg     2460

ttacgacttg agaagtcgcc agtaaaaaaa cgagagataa aatgcaaaca gtataaaact     2520

ttgggacgcg gacaaaataa aatagtgtta tatgtccgca gttcttatta tcagacgcaa     2580

tttttggaat ggtttttgca tcggccgaaa aacgttcaaa ccgatgttgc ggttagcggt     2640

tcgtttctta tcgacgaaaa gaaagtaaaa actcgctgga attatgacgc gcttacagtc     2700

gcgcttgaac cagtttccgg aagcgagcgg gtctttgtct cacagccgtt tactattttt     2760

ccggaaaaaa gcgcagagga agaaggacag aggtatcttg gcatagacat cggcgaatac     2820

ggcattgcgt atactgcgct tgagataact ggcgacagtg caaagattct tgatcaaaat     2880

tttatttcag acccccagct taaaactctg cgcgaggagg tcaaaggatt aaaacttgac     2940

caaaggcgcg ggacatttgc catgccaagc acgaaaatcg cccgcatccg cgaaagcctt     3000

gtgcatagtt tgcggaaccg catacatcat cttgcgttaa agcacaaagc aaagattgtg     3060

tatgaattgg aagtgtcgcg ttttgaagag ggaaagcaaa aaattaagaa agtctacgct     3120

acgttaaaaa aagcggatgt gtattcagaa attgacgcgg ataaaaattt acaaacgaca     3180

gtatggggaa aattggccgt tgcaagcgaa atcagcgcaa gctatacaag ccagttttgt     3240

ggtgcgtgta aaaaattgtg gcgggcggaa atgcaggttg acgaaacaat tacaacccaa     3300

gaactaatcg gcacagttag agtcataaaa gggggcactc ttattgacgc gataaaggat     3360

tttatgcgcc cgccgatttt tgacgaaaat gacactccat ttccaaaata tagagacttt     3420

tgcgacaagc atcacatttc caaaaaaatg cgtggaaaca gctgtttgtt catttgtcca     3480

ttctgccgcg caaacgcgga tgctgatatt caagcaagcc aaacaattgc gcttttaagg     3540

tatgttaagg aagagaaaaa ggtagaggac tactttgaac gatttagaaa gctaaaaaac     3600

attaaagtgc tcggacagat gaagaaaata tgatag                               3636


<210>  17
<211>  1192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasY.5

<400>  17

Met Ala Glu Ser Lys Gln Met Gln Cys Arg Lys Cys Gly Ala Ser Met 
1               5                   10                  15      


Lys Tyr Glu Val Ile Gly Leu Gly Lys Lys Ser Cys Arg Tyr Met Cys 
            20                  25                  30          


Pro Asp Cys Gly Asn His Thr Ser Ala Arg Lys Ile Gln Asn Lys Lys 
        35                  40                  45              


Lys Arg Asp Lys Lys Tyr Gly Ser Ala Ser Lys Ala Gln Ser Gln Arg 
    50                  55                  60                  


Ile Ala Val Ala Gly Ala Leu Tyr Pro Asp Lys Lys Val Gln Thr Ile 
65                  70                  75                  80  


Lys Thr Tyr Lys Tyr Pro Ala Asp Leu Asn Gly Glu Val His Asp Arg 
                85                  90                  95      


Gly Val Ala Glu Lys Ile Glu Gln Ala Ile Gln Glu Asp Glu Ile Gly 
            100                 105                 110         


Leu Leu Gly Pro Ser Ser Glu Tyr Ala Cys Trp Ile Ala Ser Gln Lys 
        115                 120                 125             


Gln Ser Glu Pro Tyr Ser Val Val Asp Phe Trp Phe Asp Ala Val Cys 
    130                 135                 140                 


Ala Gly Gly Val Phe Ala Tyr Ser Gly Ala Arg Leu Leu Ser Thr Val 
145                 150                 155                 160 


Leu Gln Leu Ser Gly Glu Glu Ser Val Leu Arg Ala Ala Leu Ala Ser 
                165                 170                 175     


Ser Pro Phe Val Asp Asp Ile Asn Leu Ala Gln Ala Glu Lys Phe Leu 
            180                 185                 190         


Ala Val Ser Arg Arg Thr Gly Gln Asp Lys Leu Gly Lys Arg Ile Gly 
        195                 200                 205             


Glu Cys Phe Ala Glu Gly Arg Leu Glu Ala Leu Gly Ile Lys Asp Arg 
    210                 215                 220                 


Met Arg Glu Phe Val Gln Ala Ile Asp Val Ala Gln Thr Ala Gly Gln 
225                 230                 235                 240 


Arg Phe Ala Ala Lys Leu Lys Ile Phe Gly Ile Ser Gln Met Pro Glu 
                245                 250                 255     


Ala Lys Gln Trp Asn Asn Asp Ser Gly Leu Thr Val Cys Ile Leu Pro 
            260                 265                 270         


Asp Tyr Tyr Val Pro Glu Glu Asn Arg Ala Asp Gln Leu Val Val Leu 
        275                 280                 285             


Leu Arg Arg Leu Arg Glu Ile Ala Tyr Cys Met Gly Ile Glu Asp Glu 
    290                 295                 300                 


Ala Gly Phe Glu His Leu Gly Ile Asp Pro Gly Ala Leu Ser Asn Phe 
305                 310                 315                 320 


Ser Asn Gly Asn Pro Lys Arg Gly Phe Leu Gly Arg Leu Leu Asn Asn 
                325                 330                 335     


Asp Ile Ile Ala Leu Ala Asn Asn Met Ser Ala Met Thr Pro Tyr Trp 
            340                 345                 350         


Glu Gly Arg Lys Gly Glu Leu Ile Glu Arg Leu Ala Trp Leu Lys His 
        355                 360                 365             


Arg Ala Glu Gly Leu Tyr Leu Lys Glu Pro His Phe Gly Asn Ser Trp 
    370                 375                 380                 


Ala Asp His Arg Ser Arg Ile Phe Ser Arg Ile Ala Gly Trp Leu Ser 
385                 390                 395                 400 


Gly Cys Ala Gly Lys Leu Lys Ile Ala Lys Asp Gln Ile Ser Gly Val 
                405                 410                 415     


Arg Thr Asp Leu Phe Leu Leu Lys Arg Leu Leu Asp Ala Val Pro Gln 
            420                 425                 430         


Ser Ala Pro Ser Pro Asp Phe Ile Ala Ser Ile Ser Ala Leu Asp Arg 
        435                 440                 445             


Phe Leu Glu Ala Ala Glu Ser Ser Gln Asp Pro Ala Glu Gln Val Arg 
    450                 455                 460                 


Ala Leu Tyr Ala Phe His Leu Asn Ala Pro Ala Val Arg Ser Ile Ala 
465                 470                 475                 480 


Asn Lys Ala Val Gln Arg Ser Asp Ser Gln Glu Trp Leu Ile Lys Glu 
                485                 490                 495     


Leu Asp Ala Val Asp His Leu Glu Phe Asn Lys Ala Phe Pro Phe Phe 
            500                 505                 510         


Ser Asp Thr Gly Lys Lys Lys Lys Lys Gly Ala Asn Ser Asn Gly Ala 
        515                 520                 525             


Pro Ser Glu Glu Glu Tyr Thr Glu Thr Glu Ser Ile Gln Gln Pro Glu 
    530                 535                 540                 


Asp Ala Glu Gln Glu Val Asn Gly Gln Glu Gly Asn Gly Ala Ser Lys 
545                 550                 555                 560 


Asn Gln Lys Lys Phe Gln Arg Ile Pro Arg Phe Phe Gly Glu Gly Ser 
                565                 570                 575     


Arg Ser Glu Tyr Arg Ile Leu Thr Glu Ala Pro Gln Tyr Phe Asp Met 
            580                 585                 590         


Phe Cys Asn Asn Met Arg Ala Ile Phe Met Gln Leu Glu Ser Gln Pro 
        595                 600                 605             


Arg Lys Ala Pro Arg Asp Phe Lys Cys Phe Leu Gln Asn Arg Leu Gln 
    610                 615                 620                 


Lys Leu Tyr Lys Gln Thr Phe Leu Asn Ala Arg Ser Asn Lys Cys Arg 
625                 630                 635                 640 


Ala Leu Leu Glu Ser Val Leu Ile Ser Trp Gly Glu Phe Tyr Thr Tyr 
                645                 650                 655     


Gly Ala Asn Glu Lys Lys Phe Arg Leu Arg His Glu Ala Ser Glu Arg 
            660                 665                 670         


Ser Ser Asp Pro Asp Tyr Val Val Gln Gln Ala Leu Glu Ile Ala Arg 
        675                 680                 685             


Arg Leu Phe Leu Phe Gly Phe Glu Trp Arg Asp Cys Ser Ala Gly Glu 
    690                 695                 700                 


Arg Val Asp Leu Val Glu Ile His Lys Lys Ala Ile Ser Phe Leu Leu 
705                 710                 715                 720 


Ala Ile Thr Gln Ala Glu Val Ser Val Gly Ser Tyr Asn Trp Leu Gly 
                725                 730                 735     


Asn Ser Thr Val Ser Arg Tyr Leu Ser Val Ala Gly Thr Asp Thr Leu 
            740                 745                 750         


Tyr Gly Thr Gln Leu Glu Glu Phe Leu Asn Ala Thr Val Leu Ser Gln 
        755                 760                 765             


Met Arg Gly Leu Ala Ile Arg Leu Ser Ser Gln Glu Leu Lys Asp Gly 
    770                 775                 780                 


Phe Asp Val Gln Leu Glu Ser Ser Cys Gln Asp Asn Leu Gln His Leu 
785                 790                 795                 800 


Leu Val Tyr Arg Ala Ser Arg Asp Leu Ala Ala Cys Lys Arg Ala Thr 
                805                 810                 815     


Cys Pro Ala Glu Leu Asp Pro Lys Ile Leu Val Leu Pro Ala Gly Ala 
            820                 825                 830         


Phe Ile Ala Ser Val Met Lys Met Ile Glu Arg Gly Asp Glu Pro Leu 
        835                 840                 845             


Ala Gly Ala Tyr Leu Arg His Arg Pro His Ser Phe Gly Trp Gln Ile 
    850                 855                 860                 


Arg Val Arg Gly Val Ala Glu Val Gly Met Asp Gln Gly Thr Ala Leu 
865                 870                 875                 880 


Ala Phe Gln Lys Pro Thr Glu Ser Glu Pro Phe Lys Ile Lys Pro Phe 
                885                 890                 895     


Ser Ala Gln Tyr Gly Pro Val Leu Trp Leu Asn Ser Ser Ser Tyr Ser 
            900                 905                 910         


Gln Ser Gln Tyr Leu Asp Gly Phe Leu Ser Gln Pro Lys Asn Trp Ser 
        915                 920                 925             


Met Arg Val Leu Pro Gln Ala Gly Ser Val Arg Val Glu Gln Arg Val 
    930                 935                 940                 


Ala Leu Ile Trp Asn Leu Gln Ala Gly Lys Met Arg Leu Glu Arg Ser 
945                 950                 955                 960 


Gly Ala Arg Ala Phe Phe Met Pro Val Pro Phe Ser Phe Arg Pro Ser 
                965                 970                 975     


Gly Ser Gly Asp Glu Ala Val Leu Ala Pro Asn Arg Tyr Leu Gly Leu 
            980                 985                 990         


Phe Pro His Ser Gly Gly Ile Glu  Tyr Ala Val Val Asp  Val Leu Asp 
        995                 1000                 1005             


Ser Ala  Gly Phe Lys Ile Leu  Glu Arg Gly Thr Ile  Ala Val Asn 
    1010                 1015                 1020             


Gly Phe  Ser Gln Lys Arg Gly  Glu Arg Gln Glu Glu  Ala His Arg 
    1025                 1030                 1035             


Glu Lys  Gln Arg Arg Gly Ile  Ser Asp Ile Gly Arg  Lys Lys Pro 
    1040                 1045                 1050             


Val Gln  Ala Glu Val Asp Ala  Ala Asn Glu Leu His  Arg Lys Tyr 
    1055                 1060                 1065             


Thr Asp  Val Ala Thr Arg Leu  Gly Cys Arg Ile Val  Val Gln Trp 
    1070                 1075                 1080             


Ala Pro  Gln Pro Lys Pro Gly  Thr Ala Pro Thr Ala  Gln Thr Val 
    1085                 1090                 1095             


Tyr Ala  Arg Ala Val Arg Thr  Glu Ala Pro Arg Ser  Gly Asn Gln 
    1100                 1105                 1110             


Glu Asp  His Ala Arg Met Lys  Ser Ser Trp Gly Tyr  Thr Trp Ser 
    1115                 1120                 1125             


Thr Tyr  Trp Glu Lys Arg Lys  Pro Glu Asp Ile Leu  Gly Ile Ser 
    1130                 1135                 1140             


Thr Gln  Val Tyr Trp Thr Gly  Gly Ile Gly Glu Ser  Cys Pro Ala 
    1145                 1150                 1155             


Val Ala  Val Ala Leu Leu Gly  His Ile Arg Ala Thr  Ser Thr Gln 
    1160                 1165                 1170             


Thr Glu  Trp Glu Lys Glu Glu  Val Val Phe Gly Arg  Leu Lys Lys 
    1175                 1180                 1185             


Phe Phe  Pro Ser 
    1190         


<210>  18
<211>  4560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasY.5

<400>  18
accaaccacc tattgcgtct ttttcgctca ttttagcaaa agtggctgtc tagacataca       60

ggtggaaagg tgagagtaaa gacatggcct gaatagcgtc ctcgtcctcg tctagacata      120

caggtggaaa ggtgagagta aagaccggag cactcatcct ctcactctat tttgtctaga      180

catacaggtg gaaaggtgag agtaaagaca aaccgtgcca cactaaaccg atgagtctag      240

acatacaggt ggaaaggtga gagtaaagac tcaagtaact acctgttctt tcacaagtct      300

agacatacag gtggaaaggt gagagtaaag actcaagtaa ctacctgttc tttcacaagt      360

ctagacctgc aggtggtaag gtgagagtaa agactcaagt aactacctgt tctttcacaa      420

gtctagacct gcaggtggta aggtgagagt aaagactttt atcctcctct ctatgcttct      480

gagtctagac atttaggtgg aaaggtgaga gtaaagactt gtggagatcc atgaacttcg      540

gcagtctaga cctgcaggtg gaaaggtgag agtaaagacg tccttcacac gatcttcctc      600

tgttagtcta ggcctgcagg tggaaaggtg agagtaaaga cgcataagcg taattgaagc      660

tctctccggt ccagaccttg tcgcgcttgt gttgcgacaa aggcggagtc cgcaataagt      720

tctttttaca atgttttttc cataaaaccg atacaatcaa gtatcggttt tgcttttttt      780

atgaaaatat gttatgctat gtgctcaaat aaaaatatca ataaaatagc gtttttttga      840

taatttatcg ctaaaattat acataatcac gcaacattgc cattctcaca caggagaaaa      900

gtcatggcag aaagcaagca gatgcaatgc cgcaagtgcg gcgcaagcat gaagtatgaa      960

gtaattggat tgggcaagaa gtcatgcaga tatatgtgcc cagattgcgg caatcacacc     1020

agcgcgcgca agattcagaa caagaaaaag cgcgacaaaa agtatggatc cgcaagcaaa     1080

gcgcagagcc agaggatagc tgtggctggc gcgctttatc cagacaaaaa agtgcagacc     1140

ataaagacct acaaataccc agcggatctg aatggcgaag ttcatgacag aggcgtcgca     1200

gagaagattg agcaggcgat tcaggaagat gagatcggcc tgcttggccc gtccagcgaa     1260

tacgcttgct ggattgcttc acaaaaacaa agcgagccgt attcagttgt agatttttgg     1320

tttgacgcgg tgtgcgcagg cggagtattc gcgtattctg gcgcgcgcct gctttccaca     1380

gtcctccagt tgagtggcga ggaaagcgtt ttgcgcgctg ctttagcatc tagcccgttt     1440

gtagatgaca ttaatttggc gcaagcggaa aagttcctag ccgttagccg gcgcacaggc     1500

caagataagc taggcaagcg cattggagaa tgtttcgcgg aaggccggct tgaagcgctt     1560

ggcatcaaag atcgcatgcg cgaattcgtg caagcgattg atgtggccca aaccgcgggc     1620

cagcggttcg cggccaagct aaagatattc ggcatcagtc agatgcctga agccaagcaa     1680

tggaacaatg attccgggct cactgtatgt attttgccgg attattatgt cccggaagaa     1740

aaccgcgcgg accagctggt tgttttgctt cggcgcttac gcgagatcgc gtattgcatg     1800

ggaattgagg atgaagcagg atttgagcat ctaggcattg accctggcgc tctttccaat     1860

ttttccaatg gcaatccaaa gcgaggattt ctcggccgcc tgctcaataa tgacattata     1920

gcgctggcaa acaacatgtc agccatgacg ccgtattggg aaggcagaaa aggcgagttg     1980

attgagcgcc ttgcatggct taaacatcgc gctgaaggat tgtatttgaa agagccacat     2040

ttcggcaact cctgggcaga ccaccgcagc aggattttca gtcgcattgc gggctggctt     2100

tccggatgcg cgggcaagct caagattgcc aaggatcaga tttcaggcgt gcgtacggat     2160

ttgtttctgc tcaagcgcct tctggatgcg gtaccgcaaa gcgcgccgtc gccggacttt     2220

attgcttcca tcagcgcgct ggatcggttt ttggaagcgg cagaaagcag ccaggatccg     2280

gcagaacagg tacgcgcttt gtacgcgttt catctgaacg cgcctgcggt ccgatccatc     2340

gccaacaagg cggtacagag gtctgattcc caggagtggc ttatcaagga actggatgct     2400

gtagatcacc ttgaattcaa caaagcattt ccgttttttt cggatacagg aaagaaaaag     2460

aagaaaggag cgaatagcaa cggagcgcct tctgaagaag aatacacgga aacagaatcc     2520

attcaacaac cagaagatgc agagcaggaa gtgaatggtc aagaaggaaa tggcgcttca     2580

aagaaccaga aaaagtttca gcgcattcct cgatttttcg gggaagggtc aaggagtgag     2640

tatcgaattt taacagaagc gccgcaatat tttgacatgt tctgcaataa tatgcgcgcg     2700

atctttatgc agctagagag tcagccgcgc aaggcgcctc gtgatttcaa atgctttctg     2760

cagaatcgtt tgcagaagct ttacaagcaa acctttctca atgctcgcag taataaatgc     2820

cgcgcgcttc tggaatccgt ccttatttca tggggagaat tttatactta tggcgcgaat     2880

gaaaagaagt ttcgtctgcg ccatgaagcg agcgagcgca gctcggatcc ggactatgtg     2940

gttcagcagg cattggaaat cgcgcgccgg cttttcttgt tcggatttga gtggcgcgat     3000

tgctctgctg gagagcgcgt ggatttggtt gaaatccaca aaaaagcaat ctcatttttg     3060

cttgcaatca ctcaggccga ggtttcagtt ggttcctata actggcttgg gaatagcacc     3120

gtgagccggt atctttcggt tgctggcaca gacacattgt acggcactca actggaggag     3180

tttttgaacg ccacagtgct ttcacagatg cgtgggctgg cgattcggct ttcatctcag     3240

gagttaaaag acggatttga tgttcagttg gagagttcgt gccaggacaa tctccagcat     3300

ctgctggtgt atcgcgcttc gcgcgacttg gctgcgtgca aacgcgctac atgcccggct     3360

gaattggatc cgaaaattct tgttctgccg gctggtgcgt ttatcgcgag cgtaatgaaa     3420

atgattgagc gtggcgatga accattagca ggcgcgtatt tgcgtcatcg gccgcattca     3480

ttcggctggc agatacgggt tcgtggagtg gcggaagtag gcatggatca gggcacagcg     3540

ctagcattcc agaagccgac tgaatcagag ccgtttaaaa taaagccgtt ttccgctcaa     3600

tacggcccag tactttggct taattcttca tcctatagcc agagccagta tctggatgga     3660

tttttaagcc agccaaagaa ttggtctatg cgggtgctac ctcaagccgg atcagtgcgc     3720

gtggaacagc gcgttgctct gatatggaat ttgcaggcag gcaagatgcg gctggagcgc     3780

tctggagcgc gcgcgttttt catgccagtg ccattcagct tcaggccgtc tggttcagga     3840

gatgaagcag tattggcgcc gaatcggtac ttgggacttt ttccgcattc cggaggaata     3900

gaatacgcgg tggtggatgt attagattcc gcgggtttca aaattcttga gcgcggtacg     3960

attgcggtaa atggcttttc ccagaagcgc ggcgaacgcc aagaggaggc acacagagaa     4020

aaacagagac gcggaatttc tgatataggc cgcaagaagc cggtgcaagc tgaagttgac     4080

gcagccaatg aattgcaccg caaatacacc gatgttgcca ctcgtttagg gtgcagaatt     4140

gtggttcagt gggcgcccca gccaaagccg ggcacagcgc cgaccgcgca aacagtatac     4200

gcgcgcgcag tgcggaccga agcgccgcga tctggaaatc aagaggatca tgctcgtatg     4260

aaatcctctt ggggatatac ctggagcacc tattgggaga agcgcaaacc agaggatatt     4320

ttgggcatct caacccaagt atactggacc ggcggtatag gcgagtcatg tcccgcagtc     4380

gcggttgcgc ttttggggca cattagggca acatccactc aaactgaatg ggaaaaagag     4440

gaggttgtat tcggtcgact gaagaagttc tttccaagct agacgatctt tttaaaaact     4500

gggctgctgg ctatcgtatg gtcagtagct cttatttttt tacttgatat atggtattat     4560


<210>  19
<211>  1287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasY.6

<400>  19

Met Lys Arg Ile Leu Asn Ser Leu Lys Val Ala Ala Leu Arg Leu Leu 
1               5                   10                  15      


Phe Arg Gly Lys Gly Ser Glu Leu Val Lys Thr Val Lys Tyr Pro Leu 
            20                  25                  30          


Val Ser Pro Val Gln Gly Ala Val Glu Glu Leu Ala Glu Ala Ile Arg 
        35                  40                  45              


His Asp Asn Leu His Leu Phe Gly Gln Lys Glu Ile Val Asp Leu Met 
    50                  55                  60                  


Glu Lys Asp Glu Gly Thr Gln Val Tyr Ser Val Val Asp Phe Trp Leu 
65                  70                  75                  80  


Asp Thr Leu Arg Leu Gly Met Phe Phe Ser Pro Ser Ala Asn Ala Leu 
                85                  90                  95      


Lys Ile Thr Leu Gly Lys Phe Asn Ser Asp Gln Val Ser Pro Phe Arg 
            100                 105                 110         


Lys Val Leu Glu Gln Ser Pro Phe Phe Leu Ala Gly Arg Leu Lys Val 
        115                 120                 125             


Glu Pro Ala Glu Arg Ile Leu Ser Val Glu Ile Arg Lys Ile Gly Lys 
    130                 135                 140                 


Arg Glu Asn Arg Val Glu Asn Tyr Ala Ala Asp Val Glu Thr Cys Phe 
145                 150                 155                 160 


Ile Gly Gln Leu Ser Ser Asp Glu Lys Gln Ser Ile Gln Lys Leu Ala 
                165                 170                 175     


Asn Asp Ile Trp Asp Ser Lys Asp His Glu Glu Gln Arg Met Leu Lys 
            180                 185                 190         


Ala Asp Phe Phe Ala Ile Pro Leu Ile Lys Asp Pro Lys Ala Val Thr 
        195                 200                 205             


Glu Glu Asp Pro Glu Asn Glu Thr Ala Gly Lys Gln Lys Pro Leu Glu 
    210                 215                 220                 


Leu Cys Val Cys Leu Val Pro Glu Leu Tyr Thr Arg Gly Phe Gly Ser 
225                 230                 235                 240 


Ile Ala Asp Phe Leu Val Gln Arg Leu Thr Leu Leu Arg Asp Lys Met 
                245                 250                 255     


Ser Thr Asp Thr Ala Glu Asp Cys Leu Glu Tyr Val Gly Ile Glu Glu 
            260                 265                 270         


Glu Lys Gly Asn Gly Met Asn Ser Leu Leu Gly Thr Phe Leu Lys Asn 
        275                 280                 285             


Leu Gln Gly Asp Gly Phe Glu Gln Ile Phe Gln Phe Met Leu Gly Ser 
    290                 295                 300                 


Tyr Val Gly Trp Gln Gly Lys Glu Asp Val Leu Arg Glu Arg Leu Asp 
305                 310                 315                 320 


Leu Leu Ala Glu Lys Val Lys Arg Leu Pro Lys Pro Lys Phe Ala Gly 
                325                 330                 335     


Glu Trp Ser Gly His Arg Met Phe Leu His Gly Gln Leu Lys Ser Trp 
            340                 345                 350         


Ser Ser Asn Phe Phe Arg Leu Phe Asn Glu Thr Arg Glu Leu Leu Glu 
        355                 360                 365             


Ser Ile Lys Ser Asp Ile Gln His Ala Thr Met Leu Ile Ser Tyr Val 
    370                 375                 380                 


Glu Glu Lys Gly Gly Tyr His Pro Gln Leu Leu Ser Gln Tyr Arg Lys 
385                 390                 395                 400 


Leu Met Glu Gln Leu Pro Ala Leu Arg Thr Lys Val Leu Asp Pro Glu 
                405                 410                 415     


Ile Glu Met Thr His Met Ser Glu Ala Val Arg Ser Tyr Ile Met Ile 
            420                 425                 430         


His Lys Ser Val Ala Gly Phe Leu Pro Asp Leu Leu Glu Ser Leu Asp 
        435                 440                 445             


Arg Asp Lys Asp Arg Glu Phe Leu Leu Ser Ile Phe Pro Arg Ile Pro 
    450                 455                 460                 


Lys Ile Asp Lys Lys Thr Lys Glu Ile Val Ala Trp Glu Leu Pro Gly 
465                 470                 475                 480 


Glu Pro Glu Glu Gly Tyr Leu Phe Thr Ala Asn Asn Leu Phe Arg Asn 
                485                 490                 495     


Phe Leu Glu Asn Pro Lys His Val Pro Arg Phe Met Ala Glu Arg Ile 
            500                 505                 510         


Pro Glu Asp Trp Thr Arg Leu Arg Ser Ala Pro Val Trp Phe Asp Gly 
        515                 520                 525             


Met Val Lys Gln Trp Gln Lys Val Val Asn Gln Leu Val Glu Ser Pro 
    530                 535                 540                 


Gly Ala Leu Tyr Gln Phe Asn Glu Ser Phe Leu Arg Gln Arg Leu Gln 
545                 550                 555                 560 


Ala Met Leu Thr Val Tyr Lys Arg Asp Leu Gln Thr Glu Lys Phe Leu 
                565                 570                 575     


Lys Leu Leu Ala Asp Val Cys Arg Pro Leu Val Asp Phe Phe Gly Leu 
            580                 585                 590         


Gly Gly Asn Asp Ile Ile Phe Lys Ser Cys Gln Asp Pro Arg Lys Gln 
        595                 600                 605             


Trp Gln Thr Val Ile Pro Leu Ser Val Pro Ala Asp Val Tyr Thr Ala 
    610                 615                 620                 


Cys Glu Gly Leu Ala Ile Arg Leu Arg Glu Thr Leu Gly Phe Glu Trp 
625                 630                 635                 640 


Lys Asn Leu Lys Gly His Glu Arg Glu Asp Phe Leu Arg Leu His Gln 
                645                 650                 655     


Leu Leu Gly Asn Leu Leu Phe Trp Ile Arg Asp Ala Lys Leu Val Val 
            660                 665                 670         


Lys Leu Glu Asp Trp Met Asn Asn Pro Cys Val Gln Glu Tyr Val Glu 
        675                 680                 685             


Ala Arg Lys Ala Ile Asp Leu Pro Leu Glu Ile Phe Gly Phe Glu Val 
    690                 695                 700                 


Pro Ile Phe Leu Asn Gly Tyr Leu Phe Ser Glu Leu Arg Gln Leu Glu 
705                 710                 715                 720 


Leu Leu Leu Arg Arg Lys Ser Val Met Thr Ser Tyr Ser Val Lys Thr 
                725                 730                 735     


Thr Gly Ser Pro Asn Arg Leu Phe Gln Leu Val Tyr Leu Pro Leu Asn 
            740                 745                 750         


Pro Ser Asp Pro Glu Lys Lys Asn Ser Asn Asn Phe Gln Glu Arg Leu 
        755                 760                 765             


Asp Thr Pro Thr Gly Leu Ser Arg Arg Phe Leu Asp Leu Thr Leu Asp 
    770                 775                 780                 


Ala Phe Ala Gly Lys Leu Leu Thr Asp Pro Val Thr Gln Glu Leu Lys 
785                 790                 795                 800 


Thr Met Ala Gly Phe Tyr Asp His Leu Phe Gly Phe Lys Leu Pro Cys 
                805                 810                 815     


Lys Leu Ala Ala Met Ser Asn His Pro Gly Ser Ser Ser Lys Met Val 
            820                 825                 830         


Val Leu Ala Lys Pro Lys Lys Gly Val Ala Ser Asn Ile Gly Phe Glu 
        835                 840                 845             


Pro Ile Pro Asp Pro Ala His Pro Val Phe Arg Val Arg Ser Ser Trp 
    850                 855                 860                 


Pro Glu Leu Lys Tyr Leu Glu Gly Leu Leu Tyr Leu Pro Glu Asp Thr 
865                 870                 875                 880 


Pro Leu Thr Ile Glu Leu Ala Glu Thr Ser Val Ser Cys Gln Ser Val 
                885                 890                 895     


Ser Ser Val Ala Phe Asp Leu Lys Asn Leu Thr Thr Ile Leu Gly Arg 
            900                 905                 910         


Val Gly Glu Phe Arg Val Thr Ala Asp Gln Pro Phe Lys Leu Thr Pro 
        915                 920                 925             


Ile Ile Pro Glu Lys Glu Glu Ser Phe Ile Gly Lys Thr Tyr Leu Gly 
    930                 935                 940                 


Leu Asp Ala Gly Glu Arg Ser Gly Val Gly Phe Ala Ile Val Thr Val 
945                 950                 955                 960 


Asp Gly Asp Gly Tyr Glu Val Gln Arg Leu Gly Val His Glu Asp Thr 
                965                 970                 975     


Gln Leu Met Ala Leu Gln Gln Val Ala Ser Lys Ser Leu Lys Glu Pro 
            980                 985                 990         


Val Phe Gln Pro Leu Arg Lys Gly  Thr Phe Arg Gln Gln  Glu Arg Ile 
        995                 1000                 1005             


Arg Lys  Ser Leu Arg Gly Cys  Tyr Trp Asn Phe Tyr  His Ala Leu 
    1010                 1015                 1020             


Met Ile  Lys Tyr Arg Ala Lys  Val Val His Glu Glu  Ser Val Gly 
    1025                 1030                 1035             


Ser Ser  Gly Leu Val Gly Gln  Trp Leu Arg Ala Phe  Gln Lys Asp 
    1040                 1045                 1050             


Leu Lys  Lys Ala Asp Val Leu  Pro Lys Lys Gly Gly  Lys Asn Gly 
    1055                 1060                 1065             


Val Asp  Lys Lys Lys Arg Glu  Ser Ser Ala Gln Asp  Thr Leu Trp 
    1070                 1075                 1080             


Gly Gly  Ala Phe Ser Lys Lys  Glu Glu Gln Gln Ile  Ala Phe Glu 
    1085                 1090                 1095             


Val Gln  Ala Ala Gly Ser Ser  Gln Phe Cys Leu Lys  Cys Gly Trp 
    1100                 1105                 1110             


Trp Phe  Gln Leu Gly Met Arg  Glu Val Asn Arg Val  Gln Glu Ser 
    1115                 1120                 1125             


Gly Val  Val Leu Asp Trp Asn  Arg Ser Ile Val Thr  Phe Leu Ile 
    1130                 1135                 1140             


Glu Ser  Ser Gly Glu Lys Val  Tyr Gly Phe Ser Pro  Gln Gln Leu 
    1145                 1150                 1155             


Glu Lys  Gly Phe Arg Pro Asp  Ile Glu Thr Phe Lys  Lys Met Val 
    1160                 1165                 1170             


Arg Asp  Phe Met Arg Pro Pro  Met Phe Asp Arg Lys  Gly Arg Pro 
    1175                 1180                 1185             


Ala Ala  Ala Tyr Glu Arg Phe  Val Leu Gly Arg Arg  His Arg Arg 
    1190                 1195                 1200             


Tyr Arg  Phe Asp Lys Val Phe  Glu Glu Arg Phe Gly  Arg Ser Ala 
    1205                 1210                 1215             


Leu Phe  Ile Cys Pro Arg Val  Gly Cys Gly Asn Phe  Asp His Ser 
    1220                 1225                 1230             


Ser Glu  Gln Ser Ala Val Val  Leu Ala Leu Ile Gly  Tyr Ile Ala 
    1235                 1240                 1245             


Asp Lys  Glu Gly Met Ser Gly  Lys Lys Leu Val Tyr  Val Arg Leu 
    1250                 1255                 1260             


Ala Glu  Leu Met Ala Glu Trp  Lys Leu Lys Lys Leu  Glu Arg Ser 
    1265                 1270                 1275             


Arg Val  Glu Glu Gln Ser Ser  Ala Gln 
    1280                 1285         


<210>  20
<211>  3864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasY.6

<400>  20
atgaagagaa ttctgaacag tctgaaagtt gctgccttga gacttctgtt tcgaggcaaa       60

ggttctgaat tagtgaagac agtcaaatat ccattggttt ccccggttca aggcgcggtt      120

gaagaacttg ctgaagcaat tcggcacgac aacctgcacc tttttgggca gaaggaaata      180

gtggatctta tggagaaaga cgaaggaacc caggtgtatt cggttgtgga tttttggttg      240

gataccctgc gtttagggat gtttttctca ccatcagcga atgcgttgaa aatcacgctg      300

ggaaaattca attctgatca ggtttcacct tttcgtaagg ttttggagca gtcacctttt      360

tttcttgcgg gtcgcttgaa ggttgaacct gcggaaagga tactttctgt tgaaatcaga      420

aagattggta aaagagaaaa cagagttgag aactatgccg ccgatgtgga gacatgcttc      480

attggtcagc tttcttcaga tgagaaacag agtatccaga agctggcaaa tgatatctgg      540

gatagcaagg atcatgagga acagagaatg ttgaaggcgg atttttttgc tatacctctt      600

ataaaagacc ccaaagctgt cacagaagaa gatcctgaaa atgaaacggc gggaaaacag      660

aaaccgcttg aattatgtgt ttgtcttgtt cctgagttgt atacccgagg tttcggctcc      720

attgctgatt ttctggttca gcgacttacc ttgctgcgtg acaaaatgag taccgacacg      780

gcggaagatt gcctcgagta tgttggcatt gaggaagaaa aaggcaatgg aatgaattcc      840

ttgctcggca cttttttgaa gaacctgcag ggtgatggtt ttgaacagat ttttcagttt      900

atgcttgggt cttatgttgg ctggcagggg aaggaagatg tactgcgcga acgattggat      960

ttgctggccg aaaaagtcaa aagattacca aagccaaaat ttgccggaga atggagtggt     1020

catcgtatgt ttctccatgg tcagctgaaa agctggtcgt cgaatttctt ccgtcttttt     1080

aatgagacgc gggaacttct ggaaagtatc aagagtgata ttcaacatgc caccatgctc     1140

attagctatg tggaagagaa aggaggctat catccacagc tgttgagtca gtatcggaag     1200

ttaatggaac aattaccggc gttgcggact aaggttttgg atcctgagat tgagatgacg     1260

catatgtccg aggctgttcg aagttacatt atgatacaca agtctgtagc gggatttctg     1320

ccggatttac tcgagtcttt ggatcgagat aaggataggg aatttttgct ttccatcttt     1380

cctcgtattc caaagataga taagaagacg aaagagatcg ttgcatggga gctaccgggc     1440

gagccagagg aaggctattt gttcacagca aacaaccttt tccggaattt tcttgagaat     1500

ccgaaacatg tgccacgatt tatggcagag aggattcccg aggattggac gcgtttgcgc     1560

tcggcccctg tgtggtttga tgggatggtg aagcaatggc agaaggtggt gaatcagttg     1620

gttgaatctc caggcgccct ttatcagttc aatgaaagtt ttttgcgtca aagactgcaa     1680

gcaatgctta cggtctataa gcgggatctc cagactgaga agtttctgaa gctgctggct     1740

gatgtctgtc gtccactcgt tgattttttc ggacttggag gaaatgatat tatcttcaag     1800

tcatgtcagg atccaagaaa gcaatggcag actgttattc cactcagtgt cccagcggat     1860

gtttatacag catgtgaagg cttggctatt cgtctccgcg aaactcttgg attcgaatgg     1920

aaaaatctga aaggacacga gcgggaagat tttttacggc tgcatcagtt gctgggaaat     1980

ctgctgttct ggatcaggga tgcgaaactt gtcgtgaagc tggaagactg gatgaacaat     2040

ccttgtgttc aggagtatgt ggaagcacga aaagccattg atcttccctt ggagattttc     2100

ggatttgagg tgccgatttt tctcaatggc tatctctttt cggaactgcg ccagctggaa     2160

ttgttgctga ggcgtaagtc ggtgatgacg tcttacagcg tcaaaacgac aggctcgcca     2220

aataggctct tccagttggt ttacctacct ctaaaccctt cagatccgga aaagaaaaat     2280

tccaacaact ttcaggagcg cctcgataca cctaccggtt tgtcgcgtcg ttttctggat     2340

cttacgctgg atgcatttgc tggcaaactc ttgacggatc cggtaactca ggaactgaag     2400

acgatggccg gtttttacga tcatctcttt ggcttcaagt tgccgtgtaa actggcggcg     2460

atgagtaacc atccaggatc ctcttccaaa atggtggttc tggcaaaacc aaagaagggt     2520

gttgctagta acatcggctt tgaacctatt cccgatcctg ctcatcctgt gttccgggtg     2580

agaagttcct ggccggagtt gaagtacctg gaggggttgt tgtatcttcc cgaagataca     2640

ccactgacca ttgaactggc ggaaacgtcg gtcagttgtc agtctgtgag ttcagtcgct     2700

ttcgatttga agaatctgac gactatcttg ggtcgtgttg gtgaattcag ggtgacggca     2760

gatcaacctt tcaagctgac gcccattatt cctgagaaag aggaatcctt catcgggaag     2820

acctacctcg gtcttgatgc tggagagcga tctggcgttg gtttcgcgat tgtgacggtt     2880

gacggcgatg ggtatgaggt gcagaggttg ggtgtgcatg aagatactca gcttatggcg     2940

cttcagcaag tcgccagcaa gtctcttaag gagccggttt tccagccact ccgtaagggc     3000

acatttcgtc agcaggagcg cattcgcaaa agcctccgcg gttgctactg gaatttctat     3060

catgcattga tgatcaagta ccgagctaaa gttgtgcatg aggaatcggt gggttcatcc     3120

ggtctggtgg ggcagtggct gcgtgcattt cagaaggatc tcaaaaaggc tgatgttctg     3180

cccaagaagg gtggaaaaaa tggtgtagac aaaaaaaaga gagaaagcag cgctcaggat     3240

accttatggg gaggagcttt ctcgaagaag gaagagcagc agatagcctt tgaggttcag     3300

gcagctggat caagccagtt ttgtctgaag tgtggttggt ggtttcagtt ggggatgcgg     3360

gaagtaaatc gtgtgcagga gagtggcgtg gtgctggact ggaaccggtc cattgtaacc     3420

ttcctcatcg aatcctcagg agaaaaggta tatggtttca gtcctcagca actggaaaaa     3480

ggctttcgtc ctgacatcga aacgttcaaa aaaatggtaa gggattttat gagacccccc     3540

atgtttgatc gcaaaggtcg gccggccgcg gcgtatgaaa gattcgtact gggacgtcgt     3600

caccgtcgtt atcgctttga taaagttttt gaagagagat ttggtcgcag tgctcttttc     3660

atctgcccgc gggtcgggtg tgggaatttc gatcactcca gtgagcagtc agccgttgtc     3720

cttgccctta ttggttacat tgctgataag gaagggatga gtggtaagaa gcttgtttat     3780

gtgaggctgg ctgaacttat ggctgagtgg aagctgaaga aactggagag atcaagggtg     3840

gaagaacaga gctcggcaca ataa                                            3864


