                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Doudna, Jennifer A
       Watters, Kyle  E
 
<120>  MODULATORS OF CAS9 POLYPEPTIDES AND METHODS OF USE THEREOF

<130>  BERK-396WO

<150>  US62/729,295
<151>  2018-09-10

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  1

Met Arg Glu Thr Ile Gln Arg Leu Leu Ala Ser Asn Leu Ser Ser Asn 
1               5                   10                  15      


Ser Ile Ala Leu Ala Thr Gly Val Ser Gln Ala Val Ile Ser Lys Leu 
            20                  25                  30          


Arg Asn Ala Lys Lys Glu Ile Gly Asn Leu Ser Leu Asn Ser Ala Glu 
        35                  40                  45              


Lys Leu Tyr Asn Tyr Gln Lys Gly Leu Glu Val Met Asn Lys Ser Ile 
    50                  55                  60                  


Glu Ile Lys Asp Gln Asn Asn Ile Val Leu Ile Asp Ser Leu Gly Gln 
65                  70                  75                  80  


Phe Phe Thr Asp Ile Glu Asn Asp Asn Asn Gly Arg Tyr Asn Ile Asp 
                85                  90                  95      


Tyr Val Leu Leu Asn Glu Val Glu His Asp Asn Gly Asn Thr Tyr Tyr 
            100                 105                 110         


Glu Val Gly Met Tyr Arg Thr Glu Glu Val Pro Phe Ser Asp Lys Val 
        115                 120                 125             


Thr Gln Asp Asn Val Glu Leu Leu Glu Asp Lys Trp Leu Gln Ile Asp 
    130                 135                 140                 


Gln Gln Gly Glu Ser Tyr Val Glu Ser Ile Phe Phe Glu Asn Glu Glu 
145                 150                 155                 160 


Asp Ala Arg Glu Tyr Ile Lys Leu Val Leu Lys Gly His Glu Thr Phe 
                165                 170                 175     


Glu Glu Thr Ala Lys Ala Ile Gly Val Ile Lys 
            180                 185         


<210>  2
<211>  564
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  2
atgagggaaa caattcaacg gctgctcgcg tctaacctca gtagcaattc aatcgctttg       60

gccacaggcg taagccaggc agttattagc aaactgcgga atgccaaaaa agagataggc      120

aacctttctc tcaatagcgc ggaaaagttg tataattacc agaagggcct ggaagtcatg      180

aacaaatcta tcgagatcaa agatcaaaac aacatagtcc tgattgacag tcttggacag      240

ttctttacag acatcgaaaa tgataataac ggtcgatata acatcgacta cgtgctgctc      300

aacgaggtag aacacgacaa tggcaacacg tactacgaag tgggcatgta tcggaccgaa      360

gaggtaccct tttccgacaa agtgacccag gacaatgtag aacttctgga ggataaatgg      420

ctgcaaatag atcaacaagg cgagagctat gttgaaagca ttttttttga gaacgaagag      480

gacgctagag aatatattaa gttggtcctg aagggtcatg agacatttga ggaaacggct      540

aaagcaatcg gagtcatcaa gtaa                                             564


<210>  3
<211>  1054
<212>  PRT
<213>  Staphylococcus aureus

<400>  3

Met Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser 
1               5                   10                  15      


Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala 
            20                  25                  30          


Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg 
        35                  40                  45              


Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg 
    50                  55                  60                  


Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp 
65                  70                  75                  80  


His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly 
                85                  90                  95      


Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His 
            100                 105                 110         


Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp 
        115                 120                 125             


Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys 
    130                 135                 140                 


Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys 
145                 150                 155                 160 


Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp 
                165                 170                 175     


Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His 
            180                 185                 190         


Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr 
        195                 200                 205             


Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp 
    210                 215                 220                 


Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu 
                245                 250                 255     


Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu 
            260                 265                 270         


Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile 
    290                 295                 300                 


Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly 
305                 310                 315                 320 


Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile 
                325                 330                 335     


Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile 
            340                 345                 350         


Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu 
        355                 360                 365             


Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile 
    370                 375                 380                 


Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala 
385                 390                 395                 400 


Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile 
                405                 410                 415     


Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser 
            420                 425                 430         


Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala 
    450                 455                 460                 


Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln 
                485                 490                 495     


Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr 
            500                 505                 510         


Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His 
        515                 520                 525             


Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu 
    530                 535                 540                 


Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr 
            580                 585                 590         


Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His 
        595                 600                 605             


Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys 
625                 630                 635                 640 


Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly 
                645                 650                 655     


Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val 
            660                 665                 670         


Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys 
        675                 680                 685             


Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys 
705                 710                 715                 720 


Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu 
                725                 730                 735     


Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys 
            740                 745                 750         


Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys 
        755                 760                 765             


Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu 
    770                 775                 780                 


Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr 
785                 790                 795                 800 


Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys 
                805                 810                 815     


Leu Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His 
            820                 825                 830         


His Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr 
        835                 840                 845             


Gly Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn 
    850                 855                 860                 


Tyr Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys 
865                 870                 875                 880 


Ile Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp 
                885                 890                 895     


Asp Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro 
            900                 905                 910         


Tyr Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr 
        915                 920                 925             


Val Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn 
    930                 935                 940                 


Ser Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln 
945                 950                 955                 960 


Ala Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn 
                965                 970                 975     


Gly Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg 
            980                 985                 990         


Ile Glu Val Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
        995                 1000                 1005             


Met Asn  Asp Lys Arg Pro Pro  Arg Ile Ile Lys Thr  Ile Ala Ser 
    1010                 1015                 1020             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1025                 1030                 1035             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1040                 1045                 1050             


Gly 
    


<210>  4
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  4

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  5
<211>  1121
<212>  PRT
<213>  Streptococcus thermophilus

<400>  5

Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210>  6
<211>  1386
<212>  PRT
<213>  Lactobacillus gasseri

<400>  6

Met Thr Lys Ile Lys Asn Glu Tyr Ile Val Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Asn Ser Cys Gly Trp Val Ala Met Asp Phe Gln Asn Thr Ile Leu Arg 
            20                  25                  30          


Met His Gly Lys Thr Ala Ile Gly Ser His Leu Phe Asp Ala Gly Asn 
        35                  40                  45              


Ser Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg Arg Arg Ile Lys 
    50                  55                  60                  


Arg Arg Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr 
65                  70                  75                  80  


Met Thr Glu Val Asp Pro Tyr Phe Phe Ala Arg Leu Lys Glu Ser Gly 
                85                  90                  95      


Leu Ser Pro Leu Asp Lys Arg Lys Asn Ala Ser Ser Ile Val Phe Pro 
            100                 105                 110         


Thr Ala Leu Glu Asp Lys Lys Phe Tyr Cys Asn Tyr Pro Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Tyr Asp Leu Met Ser Glu Asp Lys Lys Phe Asp Leu Arg 
    130                 135                 140                 


Glu Ile Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe 
145                 150                 155                 160 


Leu Tyr Asn Thr Pro Val Lys Asp Phe Glu Ala Ser Lys Ile Asp Val 
                165                 170                 175     


Lys Asp Ser Leu Glu Lys Leu Asn Glu Leu Tyr Glu Arg Leu Asp Ser 
            180                 185                 190         


Glu Phe Thr Val Glu Leu Asp Ser Ser Asn Ala Leu Glu Ile Glu Lys 
        195                 200                 205             


Ile Ile Arg Asp Lys Asn Val Phe Lys Ile Asn Lys Val Lys Ser Ile 
    210                 215                 220                 


His Gln Leu Leu Ser Leu Lys Thr Glu Asn Lys Glu Arg Thr Lys Leu 
225                 230                 235                 240 


Ile Lys Asp Val Ser Lys Gln Ile Ile Asn Ala Ile Leu Gly Tyr Lys 
                245                 250                 255     


Thr Lys Phe Glu Thr Ile Leu Leu Lys Asn Ile Ser Lys Asp Glu Ala 
            260                 265                 270         


Asp Asp Trp Glu Phe Lys Leu Thr Asp Val Asp Ala Asp Asn Lys Phe 
        275                 280                 285             


Glu Asn Leu Ile Gly Asp Leu Asn Glu Asn Glu Gln Glu Ile Leu Leu 
    290                 295                 300                 


Val Ile Arg Asn Leu Ala Asn Ala Ile Thr Leu Ser Asn Ile Val Glu 
305                 310                 315                 320 


Glu Gly Lys Thr Leu Ser Glu Ser Met Ile Asp Lys Tyr Asn Lys His 
                325                 330                 335     


Ser Asp Asp Leu Lys Leu Leu Lys Gln Val Ile Ser Asp His Pro Asp 
            340                 345                 350         


Arg Asp Lys Ala Lys Lys Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 
        355                 360                 365             


Asn Arg His Gly Lys Leu Leu Gln Ala Lys Asp Val Leu Gly Ser Lys 
    370                 375                 380                 


Lys Thr Leu Ser Lys Glu Asp Phe Tyr Lys Glu Val Lys Lys Asn Leu 
385                 390                 395                 400 


Asp Asp Ser Lys Ala Ser Gln Glu Ile Leu Asp Ala Ile Ala Leu Asp 
                405                 410                 415     


Ser Phe Met Pro Lys Gln Arg Thr Asn Glu Asn Gly Val Ile Pro Tyr 
            420                 425                 430         


Gln Leu His Gln Leu Glu Leu Asp Arg Ile Ile Lys Asn Gln Gly Lys 
        435                 440                 445             


Tyr Tyr Pro Phe Leu Lys Glu Ala Asn Pro Val Ser Ser His Leu Lys 
    450                 455                 460                 


Gln Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asn Lys Gln 
                485                 490                 495     


Thr Lys Lys Asn Gln Asn Phe Ala Trp Met Ile Arg Lys Glu Gln Gly 
            500                 505                 510         


Gln Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Met Ala Ser 
        515                 520                 525             


Ala Asn Lys Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Leu 
    530                 535                 540                 


Gly Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Phe Thr 
545                 550                 555                 560 


Val Leu Asn Glu Leu Asn Asn Ile Lys Ile Asn Gly Lys Arg Ile Ser 
                565                 570                 575     


Val Pro Leu Lys Gln Glu Leu Tyr Asn Asn Leu Phe Lys Lys Asn Ser 
            580                 585                 590         


Thr Val Thr Thr Asn Lys Leu Lys Ser Tyr Leu Lys Glu Asn Tyr Asn 
        595                 600                 605             


Leu Ile Asn Val Glu Ile Lys Gly Leu Ala Asp Glu Lys Lys Phe Asn 
    610                 615                 620                 


Ser Gly Leu Thr Thr Tyr Asn Lys Leu Arg Asn Leu Lys Ile Phe Asp 
625                 630                 635                 640 


Gln Gln Ile Asp Asp Leu Asn Tyr Asp Lys Asp Phe Glu Arg Ile Ile 
                645                 650                 655     


Glu Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Tyr Lys Asp Lys Leu 
            660                 665                 670         


Lys Thr Ile Lys Trp Leu Ser Asp Arg Gln Ile Asp Lys Leu Ser Lys 
        675                 680                 685             


Ile Arg Met Gln Gly Trp Gly Gln Leu Ser Lys Lys Leu Leu Ser Gln 
    690                 695                 700                 


Leu Thr Asp Asn Asn Gly Gln Thr Ile Ile Glu Gln Leu Trp Asp Ser 
705                 710                 715                 720 


Gln Asn Asn Phe Met Gln Ile Val Asn Gln Ala Asp Phe Lys Asp Ala 
                725                 730                 735     


Ile Ala Val Ala Asn Gln Asn Leu Leu Val Asn Thr Ser Val Glu Asp 
            740                 745                 750         


Ile Leu Asn Glu Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg 
        755                 760                 765             


Gln Val Val Lys Val Val Asp Asp Ile Val Lys Ala Ala Ser Gly Lys 
    770                 775                 780                 


Val Pro Lys Gln Ile Ala Ile Glu Phe Thr Arg Asp Ala Asp Asp Lys 
785                 790                 795                 800 


Ala Lys Ile Ser Gln Thr Arg Ala Asn Lys Leu Arg Lys Val Tyr Lys 
                805                 810                 815     


Glu Leu Ser Asn Glu Leu Ala Ser Glu Ala Ile Arg Asn Glu Leu Glu 
            820                 825                 830         


Arg Val Ala Lys Asp Gln Lys Leu Leu Lys Asp Lys Tyr Tyr Leu Tyr 
        835                 840                 845             


Phe Met Gln Leu Gly Arg Asp Ala Tyr Thr Gly Glu Pro Ile Asp Ile 
    850                 855                 860                 


Asp Glu Leu Glu Gln Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe 
865                 870                 875                 880 


Ile Lys Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Ala Val 
                885                 890                 895     


Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Tyr Gly Asn His 
            900                 905                 910         


Met Ala Ala Asp Leu Gly Ile Thr Ile Arg His Met Trp Glu Lys Trp 
        915                 920                 925             


Lys Asp Gln Gly Leu Ile Thr Lys Thr Lys Tyr Asn Asn Leu Ile Ile 
    930                 935                 940                 


Asp Pro Asp Lys Ile Asn Lys Tyr Glu Ser Ser Gly Phe Ile His Arg 
945                 950                 955                 960 


Gln Leu Val Glu Thr Ser Gln Ile Ile Lys Leu Ala Ser Thr Ile Leu 
                965                 970                 975     


Gln Ser Lys Tyr Pro Asp Thr Glu Ile Ile Val Val Lys Ala Arg Tyr 
            980                 985                 990         


Asn His Tyr Leu Arg Lys His Leu  Asn Leu Tyr Lys Ser  Arg Glu Val 
        995                 1000                 1005             


Asn Asp  Tyr His His Ala Ile  Asp Ala Tyr Leu Ser  Ala Ile Cys 
    1010                 1015                 1020             


Gly Asn  Leu Leu Tyr Gln Val  Tyr Pro Tyr Leu Arg  Pro Phe Phe 
    1025                 1030                 1035             


Val Tyr  Gly Gln Tyr Lys Lys  Phe Ser Ser Asp Pro  Lys Lys Glu 
    1040                 1045                 1050             


Lys Ile  Ile Tyr Asp Lys Thr  Arg Lys Tyr Asn Phe  Ile Ser Gln 
    1055                 1060                 1065             


Ile Phe  Glu Asn Lys Gly Asn  Asp Ile Ile Ser Leu  Glu Thr Lys 
    1070                 1075                 1080             


Lys Lys  Val Phe Asp Lys Lys  Asp Ile Ile Glu Lys  Leu Lys His 
    1085                 1090                 1095             


Ala Tyr  Asp Tyr Lys Tyr Met  Leu Val Ser Arg Glu  Thr Glu Thr 
    1100                 1105                 1110             


Arg Asp  Gln Glu Met Phe Lys  Met Thr Val Tyr Pro  Arg Leu Ser 
    1115                 1120                 1125             


Arg Asp  Thr Lys Lys Ser Arg  Asn Leu Ile Pro Lys  Lys Lys Asp 
    1130                 1135                 1140             


Met Pro  Thr Glu Ile Tyr Gly  Gly Tyr Thr Asn Asn  Ser Asp Ala 
    1145                 1150                 1155             


Tyr Met  Val Ile Ala Arg Ile  Asn Lys Lys Lys Glu  Thr Glu Tyr 
    1160                 1165                 1170             


Arg Val  Phe Gly Val Pro Met  Arg Glu Leu Val Asn  Leu Arg Lys 
    1175                 1180                 1185             


Ala Glu  Lys Lys Gly His Tyr  Asn Ala Tyr Leu Lys  Gln Val Leu 
    1190                 1195                 1200             


Glu Pro  Glu Ile Met Tyr Asn  Lys Asn Gly Lys Lys  Asn Lys Thr 
    1205                 1210                 1215             


Ile Ser  Ser Phe Glu Ile Val  Lys Ser Lys Val Pro  Tyr Lys Gln 
    1220                 1225                 1230             


Val Ile  Leu Asp Gly Asp Lys  Lys Phe Met Leu Gly  Ser Ser Thr 
    1235                 1240                 1245             


Tyr Val  Tyr Asn Ala Lys Gln  Leu Thr Leu Ser Gln  Asp Ala Met 
    1250                 1255                 1260             


Gln Ala  Ile Thr Asp Asn Cys  Glu Asn Asp Thr Asp  Glu Glu Lys 
    1265                 1270                 1275             


Ala Leu  Ile Glu Ala Tyr Asp  Glu Ile Leu Thr Asn  Ile Asp Lys 
    1280                 1285                 1290             


Tyr Leu  Pro Leu Phe Asp Ile  Asn Lys Phe Arg Asp  Lys Leu His 
    1295                 1300                 1305             


Ala Gly  Arg Glu Lys Phe Ile  Asn Leu Ser Leu Asp  Val Lys Lys 
    1310                 1315                 1320             


Asp Thr  Ile Leu Gln Val Leu  Asn Gly Leu His Asp  Asn Ala Val 
    1325                 1330                 1335             


Met Pro  Lys Ile Lys Ser Leu  Gly Leu Ser Thr Glu  Leu Gly Lys 
    1340                 1345                 1350             


Leu Gln  Ile Pro Thr Gly Val  Lys Leu Ser Glu Asn  Ala Lys Leu 
    1355                 1360                 1365             


Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu Lys Arg  Val Lys Ile 
    1370                 1375                 1380             


Ser Asp  Leu 
    1385     


<210>  7
<211>  120
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  7
gccttcgggc atggcggact tgtttttgta ctctcaagat tcaataatct tgcagaagct       60

acaaagataa ggcttcatgc cgaaatcaac accctgtcat tttatggcag ggtgttttcg      120


<210>  8
<211>  103
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  8
gcaagggcga ggagctgttc acgttttagt actctggaaa cagaatctac taaaacaagg       60

caaaatgccg tgtttatctc gtcaacttgt tggcgagatt ttt                        103


<210>  9
<211>  118
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  9
ggtcgagctg gacggcgacg ttttagatgg ttgttaggaa actaacaacc agatttaaaa       60

tcaagcaatg catcttttga tgcaaagttt caatacttgt cccgagctat cgagggac        118


<210>  10
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  10
ctgaagttca tctgcaccac gttttagagc tatct                                  35


<210>  11
<211>  59
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  11

Met Arg Glu Thr Ile Gln Arg Leu Leu Ala Ser Asn Leu Ser Ser Asn 
1               5                   10                  15      


Ser Ile Ala Leu Ala Thr Gly Val Ser Gln Ala Val Ile Ser Lys Leu 
            20                  25                  30          


Arg Asn Ala Lys Lys Glu Ile Gly Asn Leu Ser Leu Asn Ser Ala Glu 
        35                  40                  45              


Lys Leu Tyr Asn Tyr Gln Lys Gly Leu Glu Val 
    50                  55                  


<210>  12
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  12

Met Asn Lys Ser Ile Glu Ile Lys Asp Gln Asn Asn Ile Val Leu Ile 
1               5                   10                  15      


Asp Ser Leu Gly Gln Phe Phe Thr Asp Ile Glu Asn Asp Asn Asn Gly 
            20                  25                  30          


Arg Tyr Asn Ile Asp Tyr Val Leu Leu Asn Glu Val Glu His Asp Asn 
        35                  40                  45              


Gly Asn Thr Tyr Tyr Glu Val Gly Met Tyr Arg Thr Glu Glu Val Pro 
    50                  55                  60                  


Phe Ser Asp Lys Val Thr Gln Asp Asn Val Glu Leu Leu Glu Asp Lys 
65                  70                  75                  80  


Trp Leu Gln Ile Asp Gln Gln Gly Glu Ser Tyr Val Glu Ser Ile Phe 
                85                  90                  95      


Phe Glu Asn Glu Glu Asp Ala Arg Glu Tyr Ile Lys Leu Val Leu Lys 
            100                 105                 110         


Gly His Glu Thr Phe Glu Glu Thr Ala Lys Ala Ile Gly Val Ile Lys 
        115                 120                 125             


<210>  13
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  13

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  14
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  14

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  15
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  15

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  16
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  16

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  17
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  17

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  18
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  18

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  19

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  20

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  21
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  21

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  22
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  22

Asp Arg Leu Arg Arg 
1               5   


<210>  23
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  23

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  24
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  24

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  25

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  26

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  27
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  27

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  28
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  28

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  29
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  29

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  30
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  30

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  31
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  31

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  32

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  33
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  33

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  34
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  34

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  35
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  35

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  36

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  37
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  37

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  38
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  Misc_feature
<222>  (5)..(5)
<223>  this amino acid residue may be repeated

<400>  38

Gly Ser Gly Gly Ser 
1               5   


<210>  39
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  Misc_feature
<222>  (6)..(6)
<223>  This amino acid residue may be repeated

<400>  39

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  40
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  Misc_feature
<222>  (5)..(5)
<223>  This amino acid residue may be repeated

<400>  40

Gly Gly Gly Gly Ser 
1               5   


<210>  41
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  41

Gly Gly Ser Gly 
1               


<210>  42
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  42

Gly Gly Ser Gly Gly 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  43

Gly Ser Gly Ser Gly 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  44

Gly Ser Gly Gly Gly 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  45

Gly Gly Gly Ser Gly 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  46

Gly Ser Ser Ser Gly 
1               5   


<210>  47
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  47

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  48
<211>  387
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  48
atgaacaaat ctatcgagat caaagatcaa aacaacatag tcctgattga cagtcttgga       60

cagttcttta cagacatcga aaatgataat aacggtcgat ataacatcga ctacgtgctg      120

ctcaacgagg tagaacacga caatggcaac acgtactacg aagtgggcat gtatcggacc      180

gaagaggtac ccttttccga caaagtgacc caggacaatg tagaacttct ggaggataaa      240

tggctgcaaa tagatcaaca aggcgagagc tatgttgaaa gcattttttt tgagaacgaa      300

gaggacgcta gagaatatat taagttggtc ctgaagggtc atgagacatt tgaggaaacg      360

gctaaagcaa tcggagtcat caagtaa                                          387


<210>  49
<211>  129
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  49

Met Asn Glu Leu Asn Asn Lys Met Ile Glu Asp Val Val Leu Gly Glu 
1               5                   10                  15      


Val Glu Leu Ile Glu Asp Leu Gly Gln Tyr Phe Ile Asp Ile Glu Gly 
            20                  25                  30          


Asp Tyr Glu Tyr Asn Val Glu Phe Ala Thr Leu Ser Glu Val Asp Tyr 
        35                  40                  45              


Lys Val Cys Ala Leu Tyr Glu Val Ala Thr Ser Lys Thr Tyr Glu Val 
    50                  55                  60                  


Pro Tyr His Asp Lys Leu Glu Lys Glu Asp Met Lys Leu Phe Tyr Asp 
65                  70                  75                  80  


Lys Trp Leu Glu Lys Asp Gln Gln Glu Glu Thr Tyr Ile Glu Ser Val 
                85                  90                  95      


Phe Phe Val Asn Arg Glu Asp Ala Glu Ser Tyr Ile Lys Asp Val Leu 
            100                 105                 110         


Lys Gly Lys Glu Ser Leu Thr Glu Val Ala Ala Glu Ile Gly Tyr Phe 
        115                 120                 125             


Glu 
    


<210>  50
<211>  390
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  50

Ala Thr Gly Ala Ala Cys Gly Ala Ala Cys Thr Cys Ala Ala Thr Ala 
1               5                   10                  15      


Ala Thr Ala Ala Gly Ala Thr Gly Ala Thr Cys Gly Ala Ala Gly Ala 
            20                  25                  30          


Cys Gly Thr Thr Gly Thr Cys Cys Thr Cys Gly Gly Ala Gly Ala Gly 
        35                  40                  45              


Gly Thr Gly Gly Ala Gly Thr Thr Gly Ala Thr Ala Gly Ala Gly Gly 
    50                  55                  60                  


Ala Thr Cys Thr Cys Gly Gly Thr Cys Ala Gly Thr Ala Thr Thr Thr 
65                  70                  75                  80  


Cys Ala Thr Ala Gly Ala Thr Ala Thr Ala Gly Ala Ala Gly Gly Ala 
                85                  90                  95      


Gly Ala Thr Thr Ala Cys Gly Ala Ala Thr Ala Thr Ala Ala Cys Gly 
            100                 105                 110         


Thr Ala Gly Ala Ala Thr Thr Thr Gly Cys Thr Ala Cys Gly Cys Thr 
        115                 120                 125             


Cys Ala Gly Cys Gly Ala Ala Gly Thr Ala Gly Ala Cys Thr Ala Thr 
    130                 135                 140                 


Ala Ala Ala Gly Thr Cys Thr Gly Thr Gly Cys Thr Thr Thr Gly Thr 
145                 150                 155                 160 


Ala Thr Gly Ala Ala Gly Thr Ala Gly Cys Gly Ala Cys Gly Ala Gly 
                165                 170                 175     


Thr Ala Ala Gly Ala Cys Thr Thr Ala Cys Gly Ala Gly Gly Thr Gly 
            180                 185                 190         


Cys Cys Gly Thr Ala Cys Cys Ala Thr Gly Ala Thr Ala Ala Ala Thr 
        195                 200                 205             


Thr Gly Gly Ala Gly Ala Ala Gly Gly Ala Ala Gly Ala Thr Ala Thr 
    210                 215                 220                 


Gly Ala Ala Gly Cys Thr Gly Thr Thr Cys Thr Ala Cys Gly Ala Thr 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gly Cys Thr Gly Gly Ala Gly Ala Ala Ala Gly 
                245                 250                 255     


Ala Cys Cys Ala Ala Cys Ala Gly Gly Ala Ala Gly Ala Ala Ala Cys 
            260                 265                 270         


Gly Thr Ala Cys Ala Thr Ala Gly Ala Ala Thr Cys Cys Gly Thr Gly 
        275                 280                 285             


Thr Thr Thr Thr Thr Cys Gly Thr Cys Ala Ala Thr Cys Gly Ala Gly 
    290                 295                 300                 


Ala Ala Gly Ala Cys Gly Cys Thr Gly Ala Gly Ala Gly Thr Thr Ala 
305                 310                 315                 320 


Thr Ala Thr Ala Ala Ala Gly Gly Ala Thr Gly Thr Thr Thr Thr Gly 
                325                 330                 335     


Ala Ala Ala Gly Gly Ala Ala Ala Ala Gly Ala Gly Thr Cys Cys Cys 
            340                 345                 350         


Thr Gly Ala Cys Cys Gly Ala Gly Gly Thr Cys Gly Cys Gly Gly Cys 
        355                 360                 365             


Cys Gly Ala Gly Ala Thr Thr Gly Gly Thr Thr Ala Cys Thr Thr Thr 
    370                 375                 380                 


Gly Ala Gly Thr Ala Ala 
385                 390 


