                         SEQUENCE LISTING

<110>  Academisch Ziekenhuis Leiden (h.o.d.n. LUMC)
 
<120>  MuSK inhibition

<130>  P253951WO

<150>  NL2021589
<151>  2018-09-10

<150>  NL2023119
<151>  2019-05-13

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  869
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Glu Leu Val Asn Ile Pro Leu Val His Ile Leu Thr Leu Val 
1               5                   10                  15      


Ala Phe Ser Gly Thr Glu Lys Leu Pro Lys Ala Pro Val Ile Thr Thr 
            20                  25                  30          


Pro Leu Glu Thr Val Asp Ala Leu Val Glu Glu Val Ala Thr Phe Met 
        35                  40                  45              


Cys Ala Val Glu Ser Tyr Pro Gln Pro Glu Ile Ser Trp Thr Arg Asn 
    50                  55                  60                  


Lys Ile Leu Ile Lys Leu Phe Asp Thr Arg Tyr Ser Ile Arg Glu Asn 
65                  70                  75                  80  


Gly Gln Leu Leu Thr Ile Leu Ser Val Glu Asp Ser Asp Asp Gly Ile 
                85                  90                  95      


Tyr Cys Cys Thr Ala Asn Asn Gly Val Gly Gly Ala Val Glu Ser Cys 
            100                 105                 110         


Gly Ala Leu Gln Val Lys Met Lys Pro Lys Ile Thr Arg Pro Pro Ile 
        115                 120                 125             


Asn Val Lys Ile Ile Glu Gly Leu Lys Ala Val Leu Pro Cys Thr Thr 
    130                 135                 140                 


Met Gly Asn Pro Lys Pro Ser Val Ser Trp Ile Lys Gly Asp Ser Pro 
145                 150                 155                 160 


Leu Arg Glu Asn Ser Arg Ile Ala Val Leu Glu Ser Gly Ser Leu Arg 
                165                 170                 175     


Ile His Asn Val Gln Lys Glu Asp Ala Gly Gln Tyr Arg Cys Val Ala 
            180                 185                 190         


Lys Asn Ser Leu Gly Thr Ala Tyr Ser Lys Val Val Lys Leu Glu Val 
        195                 200                 205             


Glu Val Phe Ala Arg Ile Leu Arg Ala Pro Glu Ser His Asn Val Thr 
    210                 215                 220                 


Phe Gly Ser Phe Val Thr Leu His Cys Thr Ala Thr Gly Ile Pro Val 
225                 230                 235                 240 


Pro Thr Ile Thr Trp Ile Glu Asn Gly Asn Ala Val Ser Ser Gly Ser 
                245                 250                 255     


Ile Gln Glu Ser Val Lys Asp Arg Val Ile Asp Ser Arg Leu Gln Leu 
            260                 265                 270         


Phe Ile Thr Lys Pro Gly Leu Tyr Thr Cys Ile Ala Thr Asn Lys His 
        275                 280                 285             


Gly Glu Lys Phe Ser Thr Ala Lys Ala Ala Ala Thr Ile Ser Ile Ala 
    290                 295                 300                 


Glu Trp Ser Lys Pro Gln Lys Asp Asn Lys Gly Tyr Cys Ala Gln Tyr 
305                 310                 315                 320 


Arg Gly Glu Val Cys Asn Ala Val Leu Ala Lys Asp Ala Leu Val Phe 
                325                 330                 335     


Leu Asn Thr Ser Tyr Ala Asp Pro Glu Glu Ala Gln Glu Leu Leu Val 
            340                 345                 350         


His Thr Ala Trp Asn Glu Leu Lys Val Val Ser Pro Val Cys Arg Pro 
        355                 360                 365             


Ala Ala Glu Ala Leu Leu Cys Asn His Ile Phe Gln Glu Cys Ser Pro 
    370                 375                 380                 


Gly Val Val Pro Thr Pro Ile Pro Ile Cys Arg Glu Tyr Cys Leu Ala 
385                 390                 395                 400 


Val Lys Glu Leu Phe Cys Ala Lys Glu Trp Leu Val Met Glu Glu Lys 
                405                 410                 415     


Thr His Arg Gly Leu Tyr Arg Ser Glu Met His Leu Leu Ser Val Pro 
            420                 425                 430         


Glu Cys Ser Lys Leu Pro Ser Met His Trp Asp Pro Thr Ala Cys Ala 
        435                 440                 445             


Arg Leu Pro His Leu Asp Tyr Asn Lys Glu Asn Leu Lys Thr Phe Pro 
    450                 455                 460                 


Pro Met Thr Ser Ser Lys Pro Ser Val Asp Ile Pro Asn Leu Pro Ser 
465                 470                 475                 480 


Ser Ser Ser Ser Ser Phe Ser Val Ser Pro Thr Tyr Ser Met Thr Val 
                485                 490                 495     


Ile Ile Ser Ile Met Ser Ser Phe Ala Ile Phe Val Leu Leu Thr Ile 
            500                 505                 510         


Thr Thr Leu Tyr Cys Cys Arg Arg Arg Lys Gln Trp Lys Asn Lys Lys 
        515                 520                 525             


Arg Glu Ser Ala Ala Val Thr Leu Thr Thr Leu Pro Ser Glu Leu Leu 
    530                 535                 540                 


Leu Asp Arg Leu His Pro Asn Pro Met Tyr Gln Arg Met Pro Leu Leu 
545                 550                 555                 560 


Leu Asn Pro Lys Leu Leu Ser Leu Glu Tyr Pro Arg Asn Asn Ile Glu 
                565                 570                 575     


Tyr Val Arg Asp Ile Gly Glu Gly Ala Phe Gly Arg Val Phe Gln Ala 
            580                 585                 590         


Arg Ala Pro Gly Leu Leu Pro Tyr Glu Pro Phe Thr Met Val Ala Val 
        595                 600                 605             


Lys Met Leu Lys Glu Glu Ala Ser Ala Asp Met Gln Ala Asp Phe Gln 
    610                 615                 620                 


Arg Glu Ala Ala Leu Met Ala Glu Phe Asp Asn Pro Asn Ile Val Lys 
625                 630                 635                 640 


Leu Leu Gly Val Cys Ala Val Gly Lys Pro Met Cys Leu Leu Phe Glu 
                645                 650                 655     


Tyr Met Ala Tyr Gly Asp Leu Asn Glu Phe Leu Arg Ser Met Ser Pro 
            660                 665                 670         


His Thr Val Cys Ser Leu Ser His Ser Asp Leu Ser Met Arg Ala Gln 
        675                 680                 685             


Val Ser Ser Pro Gly Pro Pro Pro Leu Ser Cys Ala Glu Gln Leu Cys 
    690                 695                 700                 


Ile Ala Arg Gln Val Ala Ala Gly Met Ala Tyr Leu Ser Glu Arg Lys 
705                 710                 715                 720 


Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn 
                725                 730                 735     


Met Val Val Lys Ile Ala Asp Phe Gly Leu Ser Arg Asn Ile Tyr Ser 
            740                 745                 750         


Ala Asp Tyr Tyr Lys Ala Asn Glu Asn Asp Ala Ile Pro Ile Arg Trp 
        755                 760                 765             


Met Pro Pro Glu Ser Ile Phe Tyr Asn Arg Tyr Thr Thr Glu Ser Asp 
    770                 775                 780                 


Val Trp Ala Tyr Gly Val Val Leu Trp Glu Ile Phe Ser Tyr Gly Leu 
785                 790                 795                 800 


Gln Pro Tyr Tyr Gly Met Ala His Glu Glu Val Ile Tyr Tyr Val Arg 
                805                 810                 815     


Asp Gly Asn Ile Leu Ser Cys Pro Glu Asn Cys Pro Val Glu Leu Tyr 
            820                 825                 830         


Asn Leu Met Arg Leu Cys Trp Ser Lys Leu Pro Ala Asp Arg Pro Ser 
        835                 840                 845             


Phe Thr Ser Ile His Arg Ile Leu Glu Arg Met Cys Glu Arg Ala Glu 
    850                 855                 860                 


Gly Thr Val Ser Val 
865                 


<210>  2
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Val Ile Thr Thr Pro Leu Glu Thr Val Asp Ala Leu Val Glu Glu 
1               5                   10                  15      


Val Ala Thr Phe Met Cys Ala Val Glu Ser Tyr Pro Gln Pro Glu Ile 
            20                  25                  30          


Ser Trp Thr Arg Asn Lys Ile Leu Ile Lys Leu Phe Asp Thr Arg Tyr 
        35                  40                  45              


Ser Ile Arg Glu Asn Gly Gln Leu Leu Thr Ile Leu Ser Val Glu Asp 
    50                  55                  60                  


Ser Asp Asp Gly Ile Tyr Cys Cys Thr Ala Asn Asn Gly Val Gly Gly 
65                  70                  75                  80  


Ala Val Glu Ser Cys Gly Ala Leu Gln Val 
                85                  90  


<210>  3
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Oligo-dT40VN


<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  n is a, c, g, or t

<400>  3
aagcagtggt atcaacgcag agtacttttt tttttttttt tttttttttt tttttttttt       60

tttttvn                                                                 67


<210>  4
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer BC-TSO


<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  riboguanosines

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  LNA-modified guanosine

<400>  4
aagcagtggt atcaacgcag agtacatggg                                        30


<210>  5
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  General Fw

<400>  5
cttaagcagt ggtatcaacg cagagtacat g                                      31


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG HC rev

<400>  6
ggaaggtgtg cacgccgctg gtc                                               23


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer hkappaLC rev

<400>  7
ctgatgggtg acttcgcmg                                                    19


<210>  8
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer hlambdaLC rev

<400>  8
cacacyagtg tggccttgtt ggcttg                                            26


<210>  9
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Arg Ser Ala Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Phe Gln Leu Gly Pro Pro Arg Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Phe Asn Phe Ser Thr Tyr Thr 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  11

Ile Ser Ser Arg Ser Ala Tyr Lys 
1               5               


<210>  12
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Arg Asp Phe Phe Gln Leu Gly Pro Pro Arg Phe Asp Ser 
1               5                   10                  


<210>  13
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Arg Ile Ser Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Tyr Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Pro Met Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Ser Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Arg Ile Ser Ser Phe 
1               5       


<210>  15
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Ala Ser 
1           


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Gln Ser Tyr Ser Pro Met Tyr Thr 
1               5                   


<210>  17
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Ser Asn Gly Asp Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Leu Ala Val Ala Gly Thr His Phe Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Ser Leu Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Phe Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  19

Ile Gly Ser Asn Gly Asp Tyr Ile 
1               5               


<210>  20
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Arg Gly Gln Leu Ala Val Ala Gly Thr His Phe Asp Tyr 
1               5                   10                  


<210>  21
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Lys Val Asn Lys Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asn Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Phe Cys Gln Gln Ser Tyr Ser Pro Leu Cys 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  22
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Lys Val Asn Lys Tyr 
1               5       


<210>  23
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Ala Ser 
1           


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Gln Ser Tyr Ser Pro Leu Cys Thr 
1               5                   


<210>  25
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Ser Ser Gly Thr Phe Ile Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asp Leu Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Arg Ile Ala Val Ala Gly Thr His Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Phe Thr Phe Ser Asp Phe Thr 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  27

Ile Gly Ser Ser Gly Thr Phe Ile 
1               5               


<210>  28
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Arg Gly Arg Ile Ala Val Ala Gly Thr His Phe Asp Leu 
1               5                   10                  


<210>  29
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Val Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Gly Gln 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Ser Ser Gly Val Thr Lys Phe Ala Glu Lys Phe 
    50                  55                  60                  


Glu Gly Arg Ala Thr Met Thr Arg Asp Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Ile Asp Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Ser Leu Gly Val Tyr Tyr Val Gly Met Val Ala Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Tyr Thr Phe Thr Gly Gln Tyr 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  31

Ile Asn Pro Ser Ser Gly Val Thr 
1               5               


<210>  32
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala Thr Leu Ser Leu Gly Val Tyr Tyr Val Gly Met Val Ala 
1               5                   10                  


<210>  33
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Ser Gly Asp Gly Leu Ala Gln Gln His Val 
            20                  25                  30          


Tyr Trp Phe Gln Gln Arg Pro Gly Gln Ala Pro Leu Leu Ile Ile Tyr 
        35                  40                  45              


Lys Asp Ile Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Ala Met Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Gly Asp Arg Thr Ala Thr Ser 
                85                  90                  95      


Val Leu Phe Gly Gly Gly Thr Lys Met Thr Val Leu 
            100                 105             


<210>  34
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Leu Ala Gln Gln His 
1               5       


<210>  35
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  35

Lys Asp Ile 
1           


<210>  36
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Ser Gly Asp Arg Thr Ala Thr Ser Val Leu 
1               5                   10      


<210>  37
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Asp Leu Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gln 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ala Ser 
            20                  25                  30          


Thr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Gly Asp Ser His His Ile Tyr Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Arg Asn Ser Phe Phe 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Leu Leu Arg Leu Gly Val Gly Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Ser Leu Val Ala Val Ser Ser 
        115                 120     


<210>  38
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Phe Asp Phe Ser Ala Ser Thr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  39

Val Ser Gly Asp Ser His His Ile 
1               5               


<210>  40
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Arg Glu Arg Leu Leu Arg Leu Gly Val Gly Phe Asp Ser 
1               5                   10                  


<210>  41
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  41

Asp Ile His Met Thr Gln Ser Pro Ser Ser Leu Ser Ser Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Arg Ala Ser Gln Arg Ile Ser Gly Phe 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Thr Leu Leu Ile 
        35                  40                  45              


Ser Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Pro Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  42
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Arg Ile Ser Gly Phe 
1               5       


<210>  43
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Ala Ser 
1           


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Gln Ser Tyr Ser Pro Leu Tyr Thr 
1               5                   


<210>  45
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  45

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Gly Gly His Tyr Ile Tyr Tyr Thr Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Leu Leu Arg Leu Gly Val Gly Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Ser Leu Val Thr Val Ser Ser 
        115                 120     


<210>  46
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Phe Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  47

Ile Ser Ser Gly Gly His Tyr Ile 
1               5               


<210>  48
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  48

Ala Arg Glu Arg Leu Leu Arg Leu Gly Val Gly Phe Asp Phe 
1               5                   10                  


<210>  49
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Arg Ala Ser Gln Ser Ile Ser Gly Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Thr Glu Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys 
            100                 105         


<210>  50
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Ser Ile Ser Gly Tyr 
1               5       


<210>  51
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  51

Ala Ala Ser 
1           


<210>  52
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Gln Ser Tyr Ser Ala Leu Tyr Thr 
1               5                   


<210>  53
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Leu Asn Glu Asp Gly Ser Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Tyr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Asp Leu Ser Gly Lys Asp Glu His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  55

Leu Asn Glu Asp Gly Ser Thr Thr 
1               5               


<210>  56
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  56

Val Ser Asp Leu Ser Gly Lys Asp Glu His 
1               5                   10  


<210>  57
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  57

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Tyr Trp Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Val Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Thr Leu Glu Ile Lys 
            100                 105                 110         


<210>  58
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  58

Gln Ser Leu Leu His Ser Asn Gly Tyr Tyr Trp 
1               5                   10      


<210>  59
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  59

Leu Gly Phe 
1           


<210>  60
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Gln Gly Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  61
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  61

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Glu Leu Gln Leu Glu Glu Ser Cys 
                325                 330                 335     


Ala Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr 
            340                 345                 350         


Ile Phe Ile Thr Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Thr Val 
        355                 360                 365             


Thr Phe Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Asp Leu Lys 
    370                 375                 380                 


Gln Thr Ile Ile Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala 
385                 390                 395                 


<210>  62
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  62

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  63
<211>  377
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  63

Xaa Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  64
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  64

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  65
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11-3D9 clone amino acid sequence (translated from cDNA)

<400>  65

Gly Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Thr Arg 
        195                 200                 


<210>  66
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11-8G4 clone amino acid sequence (translated from cDNA)

<400>  66

Gly Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        195                 200         


<210>  67
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13-3D10 clone amino acid sequence (translated from cDNA)

<400>  67

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Thr 
        195                 200     


<210>  68
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13-4D3 clone amino acid sequence (translated from cDNA)

<400>  68

Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
1               5                   10                  15      


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
            20                  25                  30          


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
        35                  40                  45              


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60                  


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Lys Leu Thr Val 
                245     


<210>  69
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13-3B5 clone amino acid sequence (translated from cDNA)

<400>  69

Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10                  15      


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Arg Leu Thr Val Thr Arg 
        195                 200 


<210>  70
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11-3D9

<400>  70

Gly Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Thr 
        195                 200             


<210>  71
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11-8G4

<400>  71

Gly Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        195                 200     


<210>  72
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13-3B5

<400>  72

Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10                  15      


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Arg Leu Thr Val Thr 
        195                 


<210>  73
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13-3D10

<400>  73

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val 
        195                 200 


<210>  74
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13-4D3

<400>  74

Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
1               5                   10                  15      


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
            20                  25                  30          


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
        35                  40                  45              


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60                  


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
65                  70                  75                  80  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                85                  90                  95      


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
            100                 105                 110         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        115                 120                 125             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
    130                 135                 140                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
145                 150                 155                 160 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                165                 170                 175     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            180                 185                 190         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        195                 200                 205             


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
    210                 215                 220                 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
225                 230                 235                 240 


Tyr Ser Lys Leu Thr 
                245 


<210>  75
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Glu Leu Gln Leu Glu Glu 
                325                 330                 


<210>  76
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro 
                


<210>  77
<211>  375
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  77

Xaa Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro 
    370                 375 


<210>  78
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu 
                325 


