                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
 
<120>  GENETIC ENGINEERING OF B CELL RECEPTORS AND USES THEREOF IN 
       ANTIGEN-INDUCED ANTIBODY SECRETION

<130>  2663579

<150>  US 62/730,561
<151>  2018-09-13

<150>  US 62/840,429
<151>  2019-04-30

<160>  285   

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Furine Cleavage F1

<400>  1
cgcgcgaaac gcggaag                                                      17


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A F1

<400>  2
gagacgtgga ggagaaccct g                                                 21


<210>  3
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mini P for 170 F

<400>  3
atgtccattc tagatcttaa gtttgtgagg tgtgtcgac                              39


<210>  4
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFP for 151 F

<400>  4
atctagacct aggatgcccg ccatgaagat cg                                     32


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHJ degenerate F

<400>  5
ggraccwcts tcacmgtctc ctcag                                             25


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m3'IgHJ4-F1

<400>  6
ggatatttgt ccctgaggga gcc                                               23


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  m3'IgHJ4-R1

<400>  7
gctccaccag acctctctag acag                                              24


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHM CH2 R1

<400>  8
cgtggtggga cgaacacatt tac                                               23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHG M R1

<400>  9
ccaccacaga ggagaagatc cac                                               23


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHA CH2 R1

<400>  10
catgtgaggc tggcatctga ac                                                22


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHG1 CH1 R

<400>  11
ccaggtcact gtcactggct c                                                 21


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHJ4 F1

<400>  12
ggtcaaggaa cctcagtcac cg                                                22


<210>  13
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHM M1 R1

<400>  13
gcagtggtcc acaggttctc aaag                                              24


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  copGFPm R1

<400>  14
gtgttggtgt agccgccgtt g                                                 21


<210>  15
<211>  28
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  mH69 with PAM as in genome

<400>  15
tccgatgcat agggacaaag agtggagt                                          28


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mH69 as in the plasmid

<400>  16
tccgatgcat agggacaaag ag                                                22


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mH69 as sgRNA

<400>  17
cgatgcatag ggacaaagag                                                   20


<210>  18
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A peptide sequence

<400>  18
gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacct          57


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Furin-GSG sequence

<400>  19
cgcgcgaaac gcggaagcgg a                                                 21


<210>  20
<211>  155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutminiP

<400>  20
ggtacctttt cattccttcc tctccagttc ttctctagat ggactaggtc cttaactagc       60

gaattcggat ccctgtctca tgaatatgca aatcaggtga gtccatggtg gtaaatatag      120

ggatgtcgac acacctcaca aacttaagat ctaga                                 155


<210>  21
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPLICE DONOR in ADN157CF2 and ADN191

<400>  21
ctcctcaggt aag                                                          13


<210>  22
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SPLICE DONOR in ADN171

<400>  22
ccaggtcact gtctcgtcag gtgagtcctc gaggagtgga gtggggcact                  50


<210>  23
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  50bp SD in ADN157CF2

<400>  23
aggagaaccc tggacctctc tcctcaggta agggagtgga gtggggcact                  50


<210>  24
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  50bp SD in ADN171

<400>  24
cagtgacagt ttcttctacc tcctcaggta agggagtgga gtggggcact                  50


<210>  25
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  50bp SD ADN171

<400>  25
ccaggtcact gtctcgtcag gtgagtcctc gaggagtgga gtggggcact                  50


<210>  26
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SD 152/153/155

<400>  26
ctgacaggag gcaagaagac agattcttac ccctccattt ctcttttatc cctctctggt       60

cctcagagag tcag                                                         74


<210>  27
<211>  195
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SD156

<400>  27
ctcgaggcag tttcgtcctg tataccaggt tcacctacta ccatatctag ccctgcctgc       60

cttaagagta gcaacaagga aatagcaggg tgtagaggga tctcctgtct gacaggaggc      120

aagaagacag attcttaccc ctccatttct cttttatccc tctctggtcc tcagagagtc      180

agtccttccc aaatg                                                       195


<210>  28
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  159 (ADNSA)

<400>  28
ctgacttctt ctttctcttt cttcagagag agagagagag agagag                      46


<210>  29
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Palivizumab light chain in ADN191

<400>  29
gacatccaga tgacacagag cccctctaca ctgagcgcca gcgtgggaga cagagtgacc       60

atcacatgca agtgccagct gagcgtgggc tacatgcact ggtatcagca gaagcctggc      120

aaggccccta agctgctgat ctacgacaca agcaagctgg cctctggcgt gccctctaga      180

ttttctggca gcggctctgg caccgagttc accctgacaa tctctagcct gcagcctgac      240

gacttcgcca cctactactg cttccaaggc tctggctacc ccttcacatt cggcggaggc      300

accaagctgg aaatcaaggg ggctgatgct gcaccaactg tatccatctt cccaccatcc      360

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc      420

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac      480

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg      540

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca      600

acttcaccca ttgtcaagag cttcaacagg aatgagtgt                             639


<210>  30
<211>  370
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Palivizumab heavy chain in ADN191

<400>  30
caagtgaccc tgagagagtc tggccccgct ctggttaagc ccacacagac cctgacactg       60

acctgcacct tcagcggctt cagcctgagc acaagcggca tgtctgtcgg ctggatcaga      120

cagcctcctg gcaaggctct ggaatggctg gccgacattt ggtgggacga caagaaggac      180

tacaacccca gcctgaagtc cagactgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgaaag tgaccaacat ggaccctgcc gacaccgcca cctactactg cgccagatcc      300

atgatcacca actggtactt cgacgtctgg ggcgccggca ccacagtgac agtttcttct      360

acctcctcag                                                             370


<210>  31
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 Light chain in ADN171

<400>  31
atggacatga gggtccctgc tcagctcctg gggctcctgc tgctctggct ctctggagcc       60

agatgtgaca tccagatgac ccagtctcca tcctccctgt ctgcctctgt gggagatacc      120

gtcactatca cttgccaagc aaacggctac ttaaattggt atcaacagag gcgagggaaa      180

gccccaaaac tcctgatcta cgatgggtcc aaattggaaa gaggggtccc atcaaggttt      240

agtggaagaa gatgggggca agaatataat ctgaccatca acaatctgca gcccgaagac      300

attgcaacat atttttgtca agtgtatgag tttgtcgtcc ctgggaccag actggatttg      360

aaacgggctg atgctgcacc aactgtatcc atcttcccac catccagtga gcagttaaca      420

tctggaggtg cctcagtcgt gtgcttcttg aacaacttct accccaaaga catcaatgtc      480

aagtggaaga ttgatggcag tgaacgacaa aatggcgtcc tgaacagttg gactgatcag      540

gacagcaaag acagcaccta cagcatgagc agcaccctca cgttgaccaa ggacgagtat      600

gaacgacata acagctatac ctgtgaggcc actcacaaga catcaacttc acccattgtc      660

aagagcttca acaggaatga gtgt                                             684


<210>  32
<211>  427
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 heavy chain in ADN191

<400>  32
atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc ccactcccag       60

gtccaattgt tacagtctgg ggcagcggtg acgaagcccg gggcctcagt gagagtctcc      120

tgcgaggctt ctggatacaa cattcgtgac tactttattc attggtggcg acaagcccca      180

ggacagggcc ttcagtgggt gggatggatc aatcctaaga caggacagcc aaacaatcct      240

cgtcaatttc aaggtagagt cagtctgact cgacacgcgt cgtgggactt tgacacattt      300

tccttttaca tggacctgaa ggcactaaga tcggacgaca cggccgttta tttctgtgcg      360

cgacagcgca gcgactattg ggatttcgac gtctggggca gtggaaccca ggtcactgtc      420

tcgtcag                                                                427


<210>  33
<211>  119
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  119bp nucleotide sequence containing the mH69 site

<400>  33
agttgtggaa tatacttcag gaccacctct gtgacagcat ttatacagta tccgatgcat       60

agggacaaag agtggagtgg ggcactttct ttagatttgt gaggaatgtt ccgcactag       119


<210>  34
<211>  395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Left Homology Arm used in all the donors

<400>  34
gtaagaatgg cctctccagg tctttatttt taacctttgt tatggagttt tctgagcatt       60

gcagactaat cttggatatt tgtccctgag ggagccggct gagagaagtt gggaaataaa      120

ctgtctaggg atctcagagc ctttaggaca gattatctcc acatctttga aaaactaaga      180

atctgtgtga tggtgttggt ggagtccctg gatgatggga tagggacttt ggaggctcat      240

ttgaagaaga tgctaaaaca atcctatggc tggagggata gttggggctg tagttggaga      300

ttttcagttt ttagaataaa agtattagtt gtggaatata cttcaggacc acctctgtga      360

cagcatttat acagtatccg atgcataggg acaaa                                 395


<210>  35
<211>  492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Right Homology Arm as used in all the donors

<400>  35
gagtggagtg gggcactttc tttagatttg tgaggaatgt tccgcactag attgtttaaa       60

acttcatttg ttggaaggag agctgtctta gtgattgagt caagggagaa aggcatctag      120

cctcggtctc aaaagggtag ttgctgtcta gagaggtctg gtggagcctg caaaagtcca      180

gctttcaaag gaacacagaa gtatgtgtat ggaatattag aagatgttgc ttttactctt      240

aagttggttc ctaggaaaaa tagttaaata ctgtgacttt aaaatgtgag agggttttca      300

agtactcatt tttttaaatg tccaaaattc ttgtcaatca gtttgaggtc ttgtttgtgt      360

agaactgata ttacttaaag tttaaccgag gaatgggagt gaggctctct cataacctat      420

tcagaactga cttttaacaa taataaatta agtttcaaat atttttaaat gaattgagca      480

atgttgagtt gg                                                          492


<210>  36
<211>  1098
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence of Fig. 3C


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (886)..(886)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (890)..(890)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (902)..(904)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (909)..(909)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (920)..(920)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (926)..(926)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (931)..(931)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (937)..(938)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (941)..(941)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (949)..(949)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (952)..(952)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (954)..(954)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (966)..(966)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (969)..(970)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (976)..(978)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (986)..(987)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (989)..(991)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (993)..(994)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (997)..(997)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (999)..(1003)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1005)..(1005)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1008)..(1009)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1011)..(1013)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1020)..(1020)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1022)..(1024)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1026)..(1028)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1032)..(1032)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1035)..(1037)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1040)..(1042)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1044)..(1044)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1047)..(1053)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1055)..(1055)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1059)..(1064)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1067)..(1068)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1073)..(1073)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1075)..(1075)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1078)..(1078)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1083)..(1083)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1089)..(1092)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1094)..(1094)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1096)..(1098)
<223>  n is a, c, g, or t

<400>  36
nnnnccnccn catcctgcag acgggggccc catgttcgcc ttccgccgcg tggaggagct       60

gcacagcaac accgagctgg gcatcgtgga gtaccagcac gccttcaaga cccccatcgc      120

cttcgccaga tctcgagtcc gcgcgaaacg cggaagcgga gctactaact tcagcctgct      180

gaagcaggct ggagacgtgg aggagaaccc tggacctctc tcctcagaga gtcagtcctt      240

cccaaatgtc ttccccctcg tctcctgcga gagccccctg tctgataaga atctggtggc      300

catgggctgc ctggcccggg acttcctgcc cagcaccatt tccttcacct ggaactacca      360

gaacaacact gaagtcatcc agggtatcag aaccttccca acactgagga cagggggcaa      420

gtacctagcc acctcgcagg tgttgctgtc tcccaagagc atccttgaag gttcagatga      480

atacctggta tgcaaaatcc actacggagg caaaaacaaa gatctgcatg tgcccattcc      540

agctgtcgca gagatgaacc ccaatgtaaa tgtgttcgtc ccaccacggg atggcttctc      600

tggccctgca ccacgcaagt ctaaactcat ctgcgaggcc acgaacttcg ctccaaaacc      660

gatcacagta tcctggctaa aggatgggaa gctcgtggaa tctggcttca ccacagatcc      720

ggtgaccatc gagaacaaag gatccacacc ccaaacctac aaggtcataa gcacacttac      780

catctctgaa atcgactggc tgaacctgaa tgtgtacacc tgccgtgtgg atcacagggg      840

tctcaccttc ttgaagaacg tgtcctccac atgtgctgcc agtcantccn cagacatcct      900

annnttcana atcccccctn ctttgnggac ntcctcnnca nctagtccnc tnanctgacg      960

tgtgangann aaaaannntg gccacnngnn ngnnacngnn nnnanctnnt nnngcttctn     1020

annntnnncg anccnnnggn nncncannnn nnncntggnn nnnntcnncg cgnanggnag     1080

aancttttnn nncnannn                                                   1098


<210>  37
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HGH leader

<400>  37
atggcgacgg gttcaagaac ttccctactt cttgcatttg gcctgctttg tttgccgtgg       60

ttacaggagg gctcggca                                                     78


<210>  38
<211>  370
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 Variable Heavy following first modifications used in 
       ADN170 derivatives

<400>  38
caggtccaat tgttacagtc tggggcagcg gtgacgaagc ccggggcctc agtgagagtc       60

tcctgcgagg cttctggata caacattcgt gactacttta ttcattggtg gcgacaagcc      120

ccaggacagg gccttcagtg ggtgggatgg atcaatccta agacaggaca gccaaacaat      180

cctcgtcaat ttcaaggtag agtcagtctg actcgacacg cgtcgtggga ctttgacaca      240

ttttcctttt acatggacct gaaggcacta agatcggacg acacggccgt ttatttctgt      300

gcgcgacagc gcagcgacta ttgggatttc gacgtctggg gcagtggaac ccaggtcact      360

gtctcgtcag                                                             370


<210>  39
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 12A (coding strand)

<400>  39
tggatacaac attcgtgact actttattca ttgg                                   34


<210>  40
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 12A (complementary strand)

<400>  40
acctatgttg taagcactga tgaaataagt aacc                                   34


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of 3BNC117 Variable Heavy following first modifications used
       in ADN170 derivatives

<400>  41
ggatacaaca ttcgtgacta ctttattcat                                        30


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of 3BNC117 Variable Heavy following first modifications used
       in ADN170 derivatives

<400>  42

Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His 
1               5                   10  


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence on Figure 12A

<400>  43

Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp 
1               5                   10      


<210>  44
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 12B (coding strand)

<400>  44
atggatcaat cctaagacag gacagccaaa caatcctcgt caatttcaag gtaga            55


<210>  45
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 12B (complementary strand)

<400>  45
tacctagtta ggattctgtc ctgtcggttt gttaggagca gttaaagttc catct            55


<210>  46
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of 3BNC117 Variable Heavy following first modifications used
       in ADN170 derivatives

<400>  46
tggatcaatc ctaagacagg acagccaaac aatcctcgtc aatttcaagg t                51


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of 3BNC117 Variable Heavy following first modifications used
       in ADN170 derivatives

<400>  47

Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Figure 12B

<400>  48

Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe Gln 
1               5                   10                  15      


Gly Arg 
        


<210>  49
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 12C (coding strand)

<400>  49
acacggccgt ttatttctgt gcgcgacagc gcagcgacta ttgggatttc gacgtc           56


<210>  50
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 12C (complementary strand)

<400>  50
tgtgccggca aataaagaca cgcgctgtcg cgtcgctgat aaccctaaag ctgcag           56


<210>  51
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of 3BNC117 Variable Heavy following first modifications used
       in ADN170 derivatives

<400>  51
acggccgttt atttctgtgc gcgacagcgc agcgactatt gggatttcga cgtc             54


<210>  52
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of 3BNC117 Variable Heavy following first modifications used
       in ADN170 derivatives

<400>  52

Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe 
1               5                   10                  15      


Asp Val 
        


<210>  53
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence on Figure 12C

<400>  53

Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp 
1               5                   10                  15      


Phe Asp Val 
            


<210>  54
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 Variable Heavy following GeneART optimization

<400>  54
caggttcagc tgctgcaatc tggcgccgct gtgacaaaac ctggcgcctc tgttagagtg       60

tcctgcgagg ctagcggcta caacatcaga gactacttca tccactggtg gcggcaggct      120

ccaggacagg gacttcaatg ggtcggatgg atcaacccca agaccggcca gcctaacaac      180

cccagacagt tccagggcag agtgtccctg acaagacacg ccagctggga cttcgacacc      240

ttcagcttct acatggacct gaaggccctg agaagcgacg ataccgccgt gtacttctgc      300

gccagacaga gatccgacta ctgggatttc gacgtgtggg gcagtggaac ccaggtcact      360

gtctcgtcag gtgagtcc                                                    378


<210>  55
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 13A (coding strand)

<400>  55
tagcggctac aacatcagag actacttcat ccactgg                                37


<210>  56
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 13A (complementary strand)

<400>  56
atcgccgatg ttgtagtctc tgatgaagta ggtgacc                                37


<210>  57
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of 3BNC117 Variable Heavy following GeneART optimization

<400>  57
ggctacaaca tcagagacta cttcatccac                                        30


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence on Figure 13A

<400>  58

Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp 
1               5                   10          


<210>  59
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 13B (coding strand)

<400>  59
atggatcaac cccaagaccg gccagcctaa caaccccaga cagttccagg gcag             54


<210>  60
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 13B (complementary strand)

<400>  60
tacctagttg gggttctggc cggtcggatt gttggggtct gtcaaggtcc cgtc             54


<210>  61
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of 3BNC117 Variable Heavy following GeneART optimization

<400>  61
tggatcaacc ccaagaccgg ccagcctaac aaccccagac agttccaggg                  50


<210>  62
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 13C (coding strand)

<400>  62
ataccgccgt gtacttctgc gccagacaga gatccgacta ctgggatttc gacgtg           56


<210>  63
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 13C (complementary strand)

<400>  63
tatggcggca catgaagacg cggtctgtct ctaggctgat gaccctaaag ctgcac           56


<210>  64
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of 3BNC117 Variable Heavy following GeneART optimization

<400>  64
accgccgtgt acttctgcgc cagacagaga tccgactact gggatttcga cgtg             54


<210>  65
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 Variable Heavy following ADN's SHM optimization

<400>  65
caggttcagc tgctgcaatc tggcgccgct gtgacaaaac ctggcgcctc tgttagagtg       60

tcctgcgagg ctagcggcta caacatcaga gactacttca tccactggtg gcggcaggct      120

ccaggacagg gacttcaatg ggtcggctgg atcaacccca aaaccgggca gcctaacaac      180

cccagacagt tccagggcag agtgtccctg acaagacacg ccagctggga cttcgacacc      240

ttcagcttct acatggacct gaaggccctg agaagcgacg atacagccgt gtacttctgt      300

gctcggcagc ggtccgacta ctgggacttc gacgtgtggg gcagtggaac ccaagttact      360

gtttcgtcag gtgagtcc                                                    378


<210>  66
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 14A (coding strand)

<400>  66
tagcggctac aacatcagag actacttcat ccactgg                                37


<210>  67
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 14A (complementary strand)

<400>  67
atcgccgatg ttgtagtctc tgatgaagta ggtgacc                                37


<210>  68
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of 3BNC117 Variable Heavy following ADN's SHM optimization

<400>  68
ggctacaaca tcagagacta cttcatccac                                        30


<210>  69
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 14B (coding strand)

<400>  69
cggctggatc aaccccaaaa ccgggcagcc taacaacccc agacagttcc agggcag          57


<210>  70
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 14B (complementary strand)

<400>  70
gccgacctag ttggggtttt ggcccgtcgg attgttgggg tctgtcaagg tcccgtc          57


<210>  71
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of 3BNC117 Variable Heavy following ADN's SHM optimization

<400>  71
tggatcaacc ccaaaaccgg gcagcctaac aaccccagac agttccaggg                  50


<210>  72
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid seq of Figure 14B

<400>  72

Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
1               5                   10                  15      


Gln Gly Arg 
            


<210>  73
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence on Figure 14C (coding strand)

<400>  73
atacagccgt gtacttctgt gctcggcagc ggtccgacta ctgggacttc gacgtg           56


<210>  74
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence on Figure 14C (complementary strand)

<400>  74
tatgtcggca catgaagaca cgagccgtcg ccaggctgat gaccctgaag ctgcac           56


<210>  75
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of 3BNC117 Variable Heavy following ADN's SHM optimization

<400>  75
acagccgtgt acttctgtgc tcggcagcgg tccgactact gggacttcga cgtg             54


<210>  76
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 Variable Light following first modifications used in 
       ADN170 derivatives

<400>  76
gacatccaga tgacccagtc tccatcctcc ctgtctgcct ctgtgggaga taccgtcact       60

atcacttgcc aagcaaacgg ctacttaaat tggtatcaac agaggcgagg gaaagcccca      120

aaactcctga tctacgatgg gtccaaattg gaaagagggg tcccatcaag gtttagtgga      180

agaagatggg ggcaagaata taatctgacc atcaacaatc tgcagcccga agacattgca      240

acatattttt gtcaagtgta tgagtttgtc gtccctggga ccagactgga tttgaaacgg      300


<210>  77
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 15A (coding strand)

<400>  77
atcacttgcc aagcaaacgg ctacttaaat tggtat                                 36


<210>  78
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 15A (complementary strand)

<400>  78
tagtgaacgg ttcgtttgcc gatgaattta accata                                 36


<210>  79
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of 3BNC117 Variable Light following first modifications used
       in ADN170 derivatives

<400>  79
tgccaagcaa acggctactt aaattgg                                           27


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of 3BNC117 Variable Light following first modifications used
       in ADN170 derivatives

<400>  80

Cys Gln Ala Asn Gly Tyr Leu Asn Trp 
1               5                   


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence in Figure 15A

<400>  81

Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
1               5                   10          


<210>  82
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 15B (coding strand)

<400>  82
acgatgggtc caaattggaa agag                                              24


<210>  83
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 15B (complementary strand)

<400>  83
tgctacccag gtttaacctt tctc                                              24


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of 3BNC117 Variable Light following first modifications used
       in ADN170 derivatives

<400>  84
gatgggtcca aattggaaag a                                                 21


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of 3BNC117 Variable Light following first modifications used
       in ADN170 derivatives

<400>  85

Asp Gly Ser Lys Leu Glu Arg 
1               5           


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence in Figure 15B

<400>  86

Tyr Asp Gly Ser Lys Leu Glu Arg 
1               5               


<210>  87
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 15C (coding strand)

<400>  87
gtcaagtgta tgagtttgtc gtccctggga ccagactgga tttgaaacgg                  50


<210>  88
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 15C (complementary strand)

<400>  88
cagttcacat actcaaacag cagggaccct ggtctgacct aaactttgcc                  50


<210>  89
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of 3BNC117 Variable Light following first modifications used
       in ADN170 derivatives

<400>  89
caagtgtatg agtttgtcgt ccctgggacc agactggatt tgaaacgg                    48


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of 3BNC117 Variable Light following first modifications used
       in ADN170 derivatives

<400>  90

Gln Val Tyr Glu Phe Val Val Pro Gly Thr Arg Leu Asp Leu Lys Arg 
1               5                   10                  15      


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence in Figure 15C

<400>  91

Cys Gln Val Tyr Glu Phe Val Val Pro Gly Thr Arg Leu Asp Leu Lys 
1               5                   10                  15      


Arg 
    


<210>  92
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 Variable Light following GeneART optimization

<400>  92
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga caccgtgaca       60

atcacctgtc aggccaacgg ctacctgaac tggtatcagc agagaagagg caaggcccct      120

aagctgctga tctacgacgg cagcaagctg gaaagaggcg tgccctctag attcagcggc      180

agaagatggg gccaagagta caacctgacc atcaacaacc tgcagcctga ggatatcgcc      240

acatactttt gccaggtgta cgagttcgtg gtgcccggca caagactgga cctgaaacgg      300


<210>  93
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 16A (coding strand)

<400>  93
acaatcacct gtcaggccaa cggctacctg aactggtatc a                           41


<210>  94
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 16A (complementary strand)

<400>  94
tgttagtgga cagtccggtt gccgatggac ttgaccatag t                           41


<210>  95
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of 3BNC117 Variable Light following GeneART optimization

<400>  95
tgtcaggcca acggctacct gaactgg                                           27


<210>  96
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence in Figure 16A

<400>  96

Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr Gln 
1               5                   10                  


<210>  97
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 16B (coding strand)

<400>  97
cgacggcagc aagctggaaa gaggcg                                            26


<210>  98
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 16B (complementary strand)

<400>  98
gctgccgtcg ttcgaccttt ctccgc                                            26


<210>  99
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of 3BNC117 Variable Light following GeneART optimization

<400>  99
gacggcagca agctggaaag agg                                               23


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence in Figure 16B

<400>  100

Asp Gly Ser Lys Leu Glu Arg Gly 
1               5               


<210>  101
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence in Figure 16C (coding strand)

<400>  101
ttgccaggtg tacgagttcg tggtgcccgg cacaagactg gacctgaaac gg               52


<210>  102
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence in Figure 16C (complementary strand)

<400>  102
aacggtccac atgctcaagc accacgggcc gtgttctgac ctggactttg cc               52


<210>  103
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of 3BNC117 Variable Light following GeneART optimization

<400>  103
caggtgtacg agttcgtggt gcccggcaca agactggacc tgaaacgg                    48


<210>  104
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence on Figure 17A (coding strand)

<400>  104
tacctgccaa gctaacggct acctgaactg gtat                                   34


<210>  105
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence on Figure 17A (complementary strand)

<400>  105
atggacggtt cgattgccga tggacttgac cata                                   34


<210>  106
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 of 3BNC117 Variable Light following ADN's SHM optimization

<400>  106
tgccaagcta acggctacct gaactgg                                           27


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence in Figure 17A

<400>  107

Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
1               5                   10      


<210>  108
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence on Figure 17B (coding strand)

<400>  108
cgacggcagc aagctggaaa gaggc                                             25


<210>  109
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence on Figure 17B (complementary strand)

<400>  109
gctgccgtcg ttcgaccttt ctccg                                             25


<210>  110
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 of 3BNC117 Variable Light following ADN's SHM optimization

<400>  110
gacggcagca agctggaaag a                                                 21


<210>  111
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Top DNA sequence on Figure 17C (coding strand)

<400>  111
ctgccaagtg tacgagttcg tggtgcccgg caccagactg gacctgaagc gg               52


<210>  112
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bottom DNA sequence on Figure 17C (complementary strand)

<400>  112
gacggttcac atgctcaagc accacgggcc gtggtctgac ctggacttcg cc               52


<210>  113
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 of 3BNC117 Variable Light following ADN's SHM optimization

<400>  113
caagtgtacg agttcgtggt gcccggcacc agactggacc tgaagcgg                    48


<210>  114
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3BNC117 Variable Light following ADN's SHM optimization

<400>  114
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga caccgtgaca       60

attacctgcc aagctaacgg ctacctgaac tggtatcagc agagaagagg caaggcccct      120

aagctgctga tctacgacgg cagcaagctg gaaagaggcg tgccctctag attcagcggc      180

agaagatggg gccaagagta caacctgacc atcaacaacc tgcagcctga ggatatcgcc      240

acatacttct gccaagtgta cgagttcgtg gtgcccggca ccagactgga cctgaagcgg      300


<210>  115
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequencing of 3BNC117 Variable heavy CDR2 following SHM 
       optimization in mice


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  may be substituted by Phe or Gly

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  may be substituted by Leu

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  may be substituted by Phe or Val

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  may be substituted by Lys

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  may be substituted by Leu

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  may be substituted by Thr, Arg, Met or Asn

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  may be substituted by Lys, Pro, Asn, Gln or Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  may be substituted by Lys, Pro, Asn, Gln or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  may be substituted by Lys, Pro, Asn, Gln or Ala

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  may be substituted by Lys, Pro, His, Arg, Thr, Leu or Trp

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  may be substituted by Gln, His, Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  may be substituted by  Lys or Thr

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  may be substituted by His, Thr, Met, Lys, Ser, Pro or Val

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  may be substituted by His, Ser, Leu or Arg

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  may be substituted by Ser, Gly, Cys, Leu, His or Val

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  may be substituted by Lys or His

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  may be substituted by Val, Leu or Cys

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  may be substituted by Lys, Pro, His or Leu

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  may be substituted by Val or Cys

<400>  115

Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
1               5                   10                  15      


Gln Gly 
        


<210>  116
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequencing of 3BNC117 Variable heavy following SHM optimization 
       in mice


<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  may be substituted by Phe or Gly

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  may be substituted by Leu

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  may be substituted by Phe or Val

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  may be substituted by Lys

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  may be substituted by Leu

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  may be substituted by Thr, Arg, Met or Asn

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  may be substituted by Lys, Pro, Asn, Gln or Ala

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  may be substituted by Arg, Glu, Asp or Val

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  may be substituted by Lys, Pro, His, Arg, Thr, Leu or Trp

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  may be substituted by Gln, His, Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  may be substituted by Lys or Thr

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  may be substituted by His, Thr, Met, Lys, Ser, Pro or Val

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  may be substituted by His, Ser, Leu or Arg

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  may be substituted by Ser, Gly, Cys, Leu, His or Val

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  may be substituted by Lys or His

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  may be substituted by Val, Leu or Cys

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  may be substituted by Lys, Pro, His or Leu

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  may be substituted by Val or Cys

<220>
<221>  MISC_FEATURE
<222>  (67)..(68)
<223>  may be substituted by Gly

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  may be substituted by Arg or Gly

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  may be substituted by Arg or Val

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  may be substituted by Pro, Ile or His

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  may be substituted by Gly or Trp

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  may be substituted by Asn, Asp or Thr

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  may be substituted by Phe or Gly

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  may be substituted by Ala, Asp or Val

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  may be substituted by Leu

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  may be null

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  may be substituted by Asp, Phe, Lys, Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  may be substituted by  Leu, Asp or Trp

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  may be substituted by Asp, Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  may be substituted by Val, Leu, Asp or Cys

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  may be substituted by Ser

<400>  116

Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Gly Glu Ser 
        115                 120                 125     


<210>  117
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA mouse IgH

<400>  117
cgatgcatag ggacaaagag tgg                                               23


<210>  118
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA mouse IgK

<400>  118
tggtgcagca tcagcccctg agg                                               23


<210>  119
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA human IgH

<400>  119
ggaaagagaa ctgtcggagt ggg                                               23


<210>  120
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA human IgK

<400>  120
tggtgcagcc acagttcctg agg                                               23


<210>  121
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  121
attaattaag cggccgcgta agaatggcct ctccaggtct t                           41


<210>  122
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  122
ctccactcct cgagtttgtc cctatgcatc g                                      31


<210>  123
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  123
ggacaaactc gaggagtgga gtggggc                                           27


<210>  124
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse

<400>  124
acgcgtgtac actagtccaa ctcaacattg ctcaattcat ttaaaaatat ttgaaact         58


<210>  125
<211>  1587
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fragment for the 3BNC117-wt donor

<400>  125
ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt       60

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca      120

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga      180

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg ggtacctttt      240

cattccttcc tctccagttc ttctctagat ggactaggtc cttaactagc gaattcggat      300

ccctgtctca tgaatatgca aatcaggtga gtccatggtg gtaaatatag ggatgtcgac      360

acacctcaca aacttaagat ctagaatgga catgagggtc cctgctcagc tcctggggct      420

cctgctgctc tggctctctg gagccagatg tgacatccag atgacccagt ctccatcctc      480

cctgtctgcc tctgtgggag ataccgtcac tatcacttgc caagcaaacg gctacttaaa      540

ttggtatcaa cagaggcgag ggaaagcccc aaaactcctg atctacgatg ggtccaaatt      600

ggaaagaggg gtcccatcaa ggtttagtgg aagaagatgg gggcaagaat ataatctgac      660

catcaacaat ctgcagcccg aagacattgc aacatatttt tgtcaagtgt atgagtttgt      720

cgtccctggg accagactgg atttgaaacg ggctgatgct gcaccaactg tatccatctt      780

cccaccatcc agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa      840

cttctacccc aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg      900

cgtcctgaac agttggactg atcaggacag caaagacagc acctacagca tgagcagcac      960

cctcacgttg accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca     1020

caagacatca acttcaccca ttgtcaagag cttcaacagg aatgagtgtc gcgcgaaacg     1080

cggaagcgga gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc     1140

tggacctatg gactggacct ggaggatcct cttcttggtg gcagcagcca caggagccca     1200

ctcccaggtc caattgttac agtctggggc agcggtgacg aagcccgggg cctcagtgag     1260

agtctcctgc gaggcttctg gatacaacat tcgtgactac tttattcatt ggtggcgaca     1320

agccccagga cagggccttc agtgggtggg atggatcaat cctaagacag gacagccaaa     1380

caatcctcgt caatttcaag gtagagtcag tctgactcga cacgcgtcgt gggactttga     1440

cacattttcc ttttacatgg acctgaaggc actaagatcg gacgacacgg ccgtttattt     1500

ctgtgcgcga cagcgcagcg actattggga tttcgacgtc tggggcagtg gaacccaggt     1560

cactgtctcg tcaggtgagt cctcgag                                         1587


<210>  126
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  126
cgcgatgcat taattaagcg gccgcgtaag aatggccact ctagggcc                    48


<210>  127
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  127
cccactccct cgaggacagt tctctttcc                                         29


<210>  128
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  128
aactgtcctc gagggagtgg gtgaatcc                                          28


<210>  129
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  129
gatatcacgc gtgtacacta gtacagcact gtgctagtat ttcttagct                   49


<210>  130
<211>  1589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fragment for the human donor plasmid

<400>  130
cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct       60

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc      120

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg      180

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg gggtaccttt      240

tcattccttc ctctccagtt cttctctaga tggactaggt ccttaactag cgaattcgga      300

tccctgtctc atgaatatgc aaatcaggtg agtccatggt ggtaaatata gggatgtcga      360

cacacctcac aaacttaaga tctagaatgg acatgagggt ccctgctcag ctcctggggc      420

tcctgctgct ctggctctct ggagccagat gtgacatcca gatgacccag tctccatcct      480

ccctgtctgc ctctgtggga gataccgtca ctatcacttg ccaagcaaac ggctacttaa      540

attggtatca acagaggcga gggaaagccc caaaactcct gatctacgat gggtccaaat      600

tggaaagagg ggtcccatca aggtttagtg gaagaagatg ggggcaagaa tataatctga      660

ccatcaacaa tctgcagccc gaagacattg caacatattt ttgtcaagtg tatgagtttg      720

tcgtccctgg gaccagactg gatttgaaac gaacggtggc tgcaccatct gtcttcatct      780

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata      840

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggca      900

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca      960

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc     1020

atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt cgcgcgaaac     1080

gcggaagcgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg gaggagaacc     1140

ctggacctat ggactggacc tggaggatcc tcttcttggt ggcagcagcc acaggagccc     1200

actcccaggt ccaattgtta cagtctgggg cagcggtgac gaagcccggg gcctcagtga     1260

gagtctcctg cgaggcttct ggatacaaca ttcgtgacta ctttattcat tggtggcgac     1320

aagccccagg acagggcctt cagtgggtgg gatggatcaa tcctaagaca ggacagccaa     1380

acaatcctcg tcaatttcaa ggtagagtca gtctgactcg acacgcgtcg tgggactttg     1440

acacattttc cttttacatg gacctgaagg cactaagatc ggacgacacg gccgtttatt     1500

tctgtgcgcg acagcgcagc gactattggg atttcgacgt ctggggcagt ggaacccagg     1560

tcactgtctc gtcaggtgag tcctcgagg                                       1589


<210>  131
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  131
cgcgcgaaac gcggaag                                                      17


<210>  132
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for mouse IgG2a (reverse)

<400>  132
ccaccacaga ggagaagatc cac                                               23


<210>  133
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for mouse IgM (reverse)

<400>  133
cgtggtggga cgaacacatt tac                                               23


<210>  134
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  for mouse IgA (reverse)

<400>  134
catgtgaggc tggcatctga ac                                                22


<210>  135
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER mouse IgH (forward)

<400>  135
ggatatttgt ccctgaggga gcc                                               23


<210>  136
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER mouse IgH (reverse)

<400>  136
gccatcttga ctccaactca acattg                                            26


<210>  137
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer mouse IgK(forward)

<400>  137
agtccaactg ttcaggacgc c                                                 21


<210>  138
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer mouse IgK(reverse)

<400>  138
gtgtggctaa aaattgtccc atgtgg                                            26


<210>  139
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER human IgH(forward)

<400>  139
gctgaggaat gtgtctcagg agc                                               23


<210>  140
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER human IgH (reverse)

<400>  140
cctcaattcc agacacatat cactcatgg                                         29


<210>  141
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IgK (forward)

<400>  141
gctggaacag tcagaaggtg gag                                               23


<210>  142
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMER human IgK (reverse)

<400>  142
gctgtccttg ctgtcctgct                                                   20


<210>  143
<211>  4683
<212>  DNA
<213>  Adeno-associated virus 6


<220>
<221>  misc_feature
<223>  complete genome, GenBank: AF028704.1

<400>  143
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagcgcca tgccggggtt ttacgagatt gtgattaagg tccccagcga      360

ccttgacgag catctgcccg gcatttctga cagctttgtg aactgggtgg ccgagaagga      420

atgggagttg ccgccagatt ctgacatgga tctgaatctg attgagcagg cacccctgac      480

cgtggccgag aagctgcagc gcgacttcct ggtccagtgg cgccgcgtga gtaaggcccc      540

ggaggccctc ttctttgttc agttcgagaa gggcgagtcc tacttccacc tccatattct      600

ggtggagacc acgggggtca aatccatggt gctgggccgc ttcctgagtc agattaggga      660

caagctggtg cagaccatct accgcgggat cgagccgacc ctgcccaact ggttcgcggt      720

gaccaagacg cgtaatggcg ccggaggggg gaacaaggtg gtggacgagt gctacatccc      780

caactacctc ctgcccaaga ctcagcccga gctgcagtgg gcgtggacta acatggagga      840

gtatataagc gcgtgtttaa acctggccga gcgcaaacgg ctcgtggcgc acgacctgac      900

ccacgtcagc cagacccagg agcagaacaa ggagaatctg aaccccaatt ctgacgcgcc      960

tgtcatccgg tcaaaaacct ccgcacgcta catggagctg gtcgggtggc tggtggaccg     1020

gggcatcacc tccgagaagc agtggatcca ggaggaccag gcctcgtaca tctccttcaa     1080

cgccgcctcc aactcgcggt cccagatcaa ggccgctctg gacaatgccg gcaagatcat     1140

ggcgctgacc aaatccgcgc ccgactacct ggtaggcccc gctccgcccg ccgacattaa     1200

aaccaaccgc atttaccgca tcctggagct gaacggctac gaccctgcct acgccggctc     1260

cgtctttctc ggctgggccc agaaaaggtt cggaaaacgc aacaccatct ggctgtttgg     1320

gccggccacc acgggcaaga ccaacatcgc ggaagccatc gcccacgccg tgcccttcta     1380

cggctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg acaagatggt     1440

gatctggtgg gaggagggca agatgacggc caaggtcgtg gagtccgcca aggccattct     1500

cggcggcagc aaggtgcgcg tggaccaaaa gtgcaagtcg tccgcccaga tcgatcccac     1560

ccccgtgatc gtcacctcca acaccaacat gtgcgccgtg attgacggga acagcaccac     1620

cttcgagcac cagcagccgt tgcaggaccg gatgttcaaa tttgaactca cccgccgtct     1680

ggagcatgac tttggcaagg tgacaaagca ggaagtcaaa gagttcttcc gctgggcgca     1740

ggatcacgtg accgaggtgg cgcatgagtt ctacgtcaga aagggtggag ccaacaagag     1800

acccgccccc gatgacgcgg ataaaagcga gcccaagcgg gcctgcccct cagtcgcgga     1860

tccatcgacg tcagacgcgg aaggagctcc ggtggacttt gccgacaggt accaaaacaa     1920

atgttctcgt cacgcgggca tgcttcagat gctgtttccc tgcaaaacat gcgagagaat     1980

gaatcagaat ttcaacattt gcttcacgca cgggaccaga gactgttcag aatgtttccc     2040

cggcgtgtca gaatctcaac cggtcgtcag aaagaggacg tatcggaaac tctgtgccat     2100

tcatcatctg ctggggcggg ctcccgagat tgcttgctcg gcctgcgatc tggtcaacgt     2160

ggatctggat gactgtgttt ctgagcaata aatgacttaa accaggtatg gctgccgatg     2220

gttatcttcc agattggctc gaggacaacc tctctgaggg cattcgcgag tggtgggact     2280

tgaaacctgg agccccgaaa cccaaagcca accagcaaaa gcaggacgac ggccggggtc     2340

tggtgcttcc tggctacaag tacctcggac ccttcaacgg actcgacaag ggggagcccg     2400

tcaacgcggc ggatgcagcg gccctcgagc acgacaaggc ctacgaccag cagctcaaag     2460

cgggtgacaa tccgtacctg cggtataacc acgccgacgc cgagtttcag gagcgtctgc     2520

aagaagatac gtcttttggg ggcaacctcg ggcgagcagt cttccaggcc aagaagaggg     2580

ttctcgaacc ttttggtctg gttgaggaag gtgctaagac ggctcctgga aagaaacgtc     2640

cggtagagca gtcgccacaa gagccagact cctcctcggg cattggcaag acaggccagc     2700

agcccgctaa aaagagactc aattttggtc agactggcga ctcagagtca gtccccgacc     2760

cacaacctct cggagaacct ccagcaaccc ccgctgctgt gggacctact acaatggctt     2820

caggcggtgg cgcaccaatg gcagacaata acgaaggcgc cgacggagtg ggtaatgcct     2880

caggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc accagcaccc     2940

gaacatgggc cttgcccacc tataacaacc acctctacaa gcaaatctcc agtgcttcaa     3000

cgggggccag caacgacaac cactacttcg gctacagcac cccctggggg tattttgatt     3060

tcaacagatt ccactgccat ttctcaccac gtgactggca gcgactcatc aacaacaatt     3120

ggggattccg gcccaagaga ctcaacttca agctcttcaa catccaagtc aaggaggtca     3180

cgacgaatga tggcgtcacg accatcgcta ataaccttac cagcacggtt caagtcttct     3240

cggactcgga gtaccagttg ccgtacgtcc tcggctctgc gcaccagggc tgcctccctc     3300

cgttcccggc ggacgtgttc atgattccgc agtacggcta cctaacgctc aacaatggca     3360

gccaggcagt gggacggtca tccttttact gcctggaata tttcccatcg cagatgctga     3420

gaacgggcaa taactttacc ttcagctaca ccttcgagga cgtgcctttc cacagcagct     3480

acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccag tacctgtatt     3540

acctgaacag aactcagaat cagtccggaa gtgcccaaaa caaggacttg ctgtttagcc     3600

gggggtctcc agctggcatg tctgttcagc ccaaaaactg gctacctgga ccctgttacc     3660

ggcagcagcg cgtttctaaa acaaaaacag acaacaacaa cagcaacttt acctggactg     3720

gtgcttcaaa atataacctt aatgggcgtg aatctataat caaccctggc actgctatgg     3780

cctcacacaa agacgacaaa gacaagttct ttcccatgag cggtgtcatg atttttggaa     3840

aggagagcgc cggagcttca aacactgcat tggacaatgt catgatcaca gacgaagagg     3900

aaatcaaagc cactaacccc gtggccaccg aaagatttgg gactgtggca gtcaatctcc     3960

agagcagcag cacagaccct gcgaccggag atgtgcatgt tatgggagcc ttacctggaa     4020

tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa attcctcaca     4080

cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag cacccgcctc     4140

ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag ttttcggcta     4200

caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg gagattgaat     4260

gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat acatctaact     4320

atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat actgagcctc     4380

gccccattgg cacccgttac ctcacccgtc ccctgtaatt gtgtgttaat caataaaccg     4440

gttaattcgt gtcagttgaa ctttggtctc atgtcgttat tatcttatct ggtcaccata     4500

gcaaccggtt acacattaac tgcttagttg cgcttcgcga atacccctag tgatggagtt     4560

gcccactccc tctatgcgcg ctcgctcgct cggtggggcc ggcagagcag agctctgccg     4620

tctgcggacc tttggtccgc aggccccacc gagcgagcga gcgcgcatag agggagtggg     4680

caa                                                                   4683


<210>  144
<211>  4393
<212>  DNA
<213>  Adeno-associated virus 8


<220>
<221>  misc_feature
<223>  complete genome, NC_006261.1

<400>  144
cagagaggga gtggccaact ccatcactag gggtagcgcg aagcgcctcc cacgctgccg       60

cgtcagcgct gacgtaaatt acgtcatagg ggagtggtcc tgtattagct gtcacgtgag      120

tgcttttgcg gcattttgcg acaccacgtg gccatttgag gtatatatgg ccgagtgagc      180

gagcaggatc tccattttga ccgcgaaatt tgaacgagca gcagccatgc cgggcttcta      240

cgagatcgtg atcaaggtgc cgagcgacct ggacgagcac ctgccgggca tttctgactc      300

gtttgtgaac tgggtggccg agaaggaatg ggagctgccc ccggattctg acatggatcg      360

gaatctgatc gagcaggcac ccctgaccgt ggccgagaag ctgcagcgcg acttcctggt      420

ccaatggcgc cgcgtgagta aggccccgga ggccctcttc tttgttcagt tcgagaaggg      480

cgagagctac tttcacctgc acgttctggt cgagaccacg ggggtcaagt ccatggtgct      540

aggccgcttc ctgagtcaga ttcgggaaaa gcttggtcca gaccatctac ccgcggggtc      600

gagccccacc ttgcccaact ggttcgcggt gaccaaagac gcggtaatgg cgccggcggg      660

ggggaacaag gtggtggacg agtgctacat ccccaactac ctcctgccca agactcagcc      720

cgagctgcag tgggcgtgga ctaacatgga ggagtatata agcgcgtgct tgaacctggc      780

cgagcgcaaa cggctcgtgg cgcagcacct gacccacgtc agccagacgc aggagcagaa      840

caaggagaat ctgaacccca attctgacgc gcccgtgatc aggtcaaaaa cctccgcgcg      900

ctatatggag ctggtcgggt ggctggtgga ccggggcatc acctccgaga agcagtggat      960

ccaggaggac caggcctcgt acatctcctt caacgccgcc tccaactcgc ggtcccagat     1020

caaggccgcg ctggacaatg ccggcaagat catggcgctg accaaatccg cgcccgacta     1080

cctggtgggg ccctcgctgc ccgcggacat tacccagaac cgcatctacc gcatcctcgc     1140

tctcaacggc tacgaccctg cctacgccgg ctccgtcttt ctcggctggg ctcagaaaaa     1200

gttcgggaaa cgcaacacca tctggctgtt tggacccgcc accaccggca agaccaacat     1260

tgcggaagcc atcgcccacg ccgtgccctt ctacggctgc gtcaactgga ccaatgagaa     1320

ctttcccttc aatgattgcg tcgacaagat ggtgatctgg tgggaggagg gcaagatgac     1380

ggccaaggtc gtggagtccg ccaaggccat tctcggcggc agcaaggtgc gcgtggacca     1440

aaagtgcaag tcgtccgccc agatcgaccc cacccccgtg atcgtcacct ccaacaccaa     1500

catgtgcgcc gtgattgacg ggaacagcac caccttcgag caccagcagc ctctccagga     1560

ccggatgttt aagttcgaac tcacccgccg tctggagcac gactttggca aggtgacaaa     1620

gcaggaagtc aaagagttct tccgctgggc cagtgatcac gtgaccgagg tggcgcatga     1680

gttttacgtc agaaagggcg gagccagcaa aagacccgcc cccgatgacg cggataaaag     1740

cgagcccaag cgggcctgcc cctcagtcgc ggatccatcg acgtcagacg cggaaggagc     1800

tccggtggac tttgccgaca ggtaccaaaa caaatgttct cgtcacgcgg gcatgcttca     1860

gatgctgttt ccctgcaaaa cgtgcgagag aatgaatcag aatttcaaca tttgcttcac     1920

acacggggtc agagactgct cagagtgttt ccccggcgtg tcagaatctc aaccggtcgt     1980

cagaaagagg acgtatcgga aactctgtgc gattcatcat ctgctggggc gggctcccga     2040

gattgcttgc tcggcctgcg atctggtcaa cgtggacctg gatgactgtg tttctgagca     2100

ataaatgact taaaccaggt atggctgccg atggttatct tccagattgg ctcgaggaca     2160

acctctctga gggcattcgc gagtggtggg cgctgaaacc tggagccccg aagcccaaag     2220

ccaaccagca aaagcaggac gacggccggg gtctggtgct tcctggctac aagtacctcg     2280

gacccttcaa cggactcgac aagggggagc ccgtcaacgc ggcggacgca gcggccctcg     2340

agcacgacaa ggcctacgac cagcagctgc aggcgggtga caatccgtac ctgcggtata     2400

accacgccga cgccgagttt caggagcgtc tgcaagaaga tacgtctttt gggggcaacc     2460

tcgggcgagc agtcttccag gccaagaagc gggttctcga acctctcggt ctggttgagg     2520

aaggcgctaa gacggctcct ggaaagaaga gaccggtaga gccatcaccc cagcgttctc     2580

cagactcctc tacgggcatc ggcaagaaag gccaacagcc cgccagaaaa agactcaatt     2640

ttggtcagac tggcgactca gagtcagttc cagaccctca acctctcgga gaacctccag     2700

cagcgccctc tggtgtggga cctaatacaa tggctgcagg cggtggcgca ccaatggcag     2760

acaataacga aggcgccgac ggagtgggta gttcctcggg aaattggcat tgcgattcca     2820

catggctggg cgacagagtc atcaccacca gcacccgaac ctgggccctg cccacctaca     2880

acaaccacct ctacaagcaa atctccaacg ggacatcggg aggagccacc aacgacaaca     2940

cctacttcgg ctacagcacc ccctgggggt attttgactt taacagattc cactgccact     3000

tttcaccacg tgactggcag cgactcatca acaacaactg gggattccgg cccaagagac     3060

tcagcttcaa gctcttcaac atccaggtca aggaggtcac gcagaatgaa ggcaccaaga     3120

ccatcgccaa taacctcacc agcaccatcc aggtgtttac ggactcggag taccagctgc     3180

cgtacgttct cggctctgcc caccagggct gcctgcctcc gttcccggcg gacgtgttca     3240

tgattcccca gtacggctac ctaacactca acaacggtag tcaggccgtg ggacgctcct     3300

ccttctactg cctggaatac tttccttcgc agatgctgag aaccggcaac aacttccagt     3360

ttacttacac cttcgaggac gtgcctttcc acagcagcta cgcccacagc cagagcttgg     3420

accggctgat gaatcctctg attgaccagt acctgtacta cttgtctcgg actcaaacaa     3480

caggaggcac ggcaaatacg cagactctgg gcttcagcca aggtgggcct aatacaatgg     3540

ccaatcaggc aaagaactgg ctgccaggac cctgttaccg ccaacaacgc gtctcaacga     3600

caaccgggca aaacaacaat agcaactttg cctggactgc tgggaccaaa taccatctga     3660

atggaagaaa ttcattggct aatcctggca tcgctatggc aacacacaaa gacgacgagg     3720

agcgtttttt tcccagtaac gggatcctga tttttggcaa acaaaatgct gccagagaca     3780

atgcggatta cagcgatgtc atgctcacca gcgaggaaga aatcaaaacc actaaccctg     3840

tggctacaga ggaatacggt atcgtggcag ataacttgca gcagcaaaac acggctcctc     3900

aaattggaac tgtcaacagc cagggggcct tacccggtat ggtctggcag aaccgggacg     3960

tgtacctgca gggtcccatc tgggccaaga ttcctcacac ggacggcaac ttccacccgt     4020

ctccgctgat gggcggcttt ggcctgaaac atcctccgcc tcagatcctg atcaagaaca     4080

cgcctgtacc tgcggatcct ccgaccacct tcaaccagtc aaagctgaac tctttcatca     4140

cgcaatacag caccggacag gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca     4200

gcaagcgctg gaaccccgag atccagtaca cctccaacta ctacaaatct acaagtgtgg     4260

actttgctgt taatacagaa ggcgtgtact ctgaaccccg ccccattggc acccgttacc     4320

tcacccgtaa tctgtaattg cctgttaatc aataaaccgg ttgattcgtt tcagttgaac     4380

tttggtctct gcg                                                        4393


<210>  145
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SD as provided in the ADN171XS

<400>  145
ccaagttact gtttcgtcag gtgagtcctc gaggagtgga gtggggcact                  50


<210>  146
<211>  2474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADN171 cassette

<400>  146
gtaagaatgg cctctccagg tctttatttt taacctttgt tatggagttt tctgagcatt       60

gcagactaat cttggatatt tgtccctgag ggagccggct gagagaagtt gggaaataaa      120

ctgtctaggg atctcagagc ctttaggaca gattatctcc acatctttga aaaactaaga      180

atctgtgtga tggtgttggt ggagtccctg gatgatggga tagggacttt ggaggctcat      240

ttgaagaaga tgctaaaaca atcctatggc tggagggata gttggggctg tagttggaga      300

ttttcagttt ttagaataaa agtattagtt gtggaatata cttcaggacc acctctgtga      360

cagcatttat acagtatccg atgcataggg acaaactcga ctgtgccttc tagttgccag      420

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact      480

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt      540

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat      600

gctggggatg cggtgggctc tatggggtac cttttcattc cttcctctcc agttcttctc      660

tagatggact aggtccttaa ctagcgaatt cggatccctg tctcatgaat atgcaaatca      720

ggtgagtcca tggtggtaaa tatagggatg tcgacacacc tcacaaactt aagatctaga      780

atggacatga gggtccctgc tcagctcctg gggctcctgc tgctctggct ctctggagcc      840

agatgtgaca tccagatgac ccagtctcca tcctccctgt ctgcctctgt gggagatacc      900

gtcactatca cttgccaagc aaacggctac ttaaattggt atcaacagag gcgagggaaa      960

gccccaaaac tcctgatcta cgatgggtcc aaattggaaa gaggggtccc atcaaggttt     1020

agtggaagaa gatgggggca agaatataat ctgaccatca acaatctgca gcccgaagac     1080

attgcaacat atttttgtca agtgtatgag tttgtcgtcc ctgggaccag actggatttg     1140

aaacgggctg atgctgcacc aactgtatcc atcttcccac catccagtga gcagttaaca     1200

tctggaggtg cctcagtcgt gtgcttcttg aacaacttct accccaaaga catcaatgtc     1260

aagtggaaga ttgatggcag tgaacgacaa aatggcgtcc tgaacagttg gactgatcag     1320

gacagcaaag acagcaccta cagcatgagc agcaccctca cgttgaccaa ggacgagtat     1380

gaacgacata acagctatac ctgtgaggcc actcacaaga catcaacttc acccattgtc     1440

aagagcttca acaggaatga gtgtcgcgcg aaacgcggaa gcggagctac taacttcagc     1500

ctgctgaagc aggctggaga cgtggaggag aaccctggac ctatggactg gacctggagg     1560

atcctcttct tggtggcagc agccacagga gcccactccc aggtccaatt gttacagtct     1620

ggggcagcgg tgacgaagcc cggggcctca gtgagagtct cctgcgaggc ttctggatac     1680

aacattcgtg actactttat tcattggtgg cgacaagccc caggacaggg ccttcagtgg     1740

gtgggatgga tcaatcctaa gacaggacag ccaaacaatc ctcgtcaatt tcaaggtaga     1800

gtcagtctga ctcgacacgc gtcgtgggac tttgacacat tttcctttta catggacctg     1860

aaggcactaa gatcggacga cacggccgtt tatttctgtg cgcgacagcg cagcgactat     1920

tgggatttcg acgtctgggg cagtggaacc caggtcactg tctcgtcagg tgagtcctcg     1980

aggagtggag tggggcactt tctttagatt tgtgaggaat gttccgcact agattgttta     2040

aaacttcatt tgttggaagg agagctgtct tagtgattga gtcaagggag aaaggcatct     2100

agcctcggtc tcaaaagggt agttgctgtc tagagaggtc tggtggagcc tgcaaaagtc     2160

cagctttcaa aggaacacag aagtatgtgt atggaatatt agaagatgtt gcttttactc     2220

ttaagttggt tcctaggaaa aatagttaaa tactgtgact ttaaaatgtg agagggtttt     2280

caagtactca tttttttaaa tgtccaaaat tcttgtcaat cagtttgagg tcttgtttgt     2340

gtagaactga tattacttaa agtttaaccg aggaatggga gtgaggctct ctcataacct     2400

attcagaact gacttttaac aataataaat taagtttcaa atatttttaa atgaattgag     2460

caatgttgag ttgg                                                       2474


<210>  147
<211>  2474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADN171XS cassette

<400>  147
gtaagaatgg cctctccagg tctttatttt taacctttgt tatggagttt tctgagcatt       60

gcagactaat cttggatatt tgtccctgag ggagccggct gagagaagtt gggaaataaa      120

ctgtctaggg atctcagagc ctttaggaca gattatctcc acatctttga aaaactaaga      180

atctgtgtga tggtgttggt ggagtccctg gatgatggga tagggacttt ggaggctcat      240

ttgaagaaga tgctaaaaca atcctatggc tggagggata gttggggctg tagttggaga      300

ttttcagttt ttagaataaa agtattagtt gtggaatata cttcaggacc acctctgtga      360

cagcatttat acagtatccg atgcataggg acaaactcga ctgtgccttc tagttgccag      420

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact      480

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt      540

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat      600

gctggggatg cggtgggctc tatggggtac cttttcattc cttcctctcc agttcttctc      660

tagatggact aggtccttaa ctagcgaatt cggatccctg tctcatgaat atgcaaatca      720

ggtgagtcca tggtggtaaa tatagggatg tcgacacacc tcacaaactt aagatctaga      780

atggacatga gggtccctgc tcagctcctg gggctcctgc tgctctggct ctctggagcc      840

agatgtgaca tccagatgac acagagccct agcagcctgt ctgccagcgt gggagacacc      900

gtgacaatta cctgccaagc taacggctac ctgaactggt atcagcagag aagaggcaag      960

gcccctaagc tgctgatcta cgacggcagc aagctggaaa gaggcgtgcc ctctagattc     1020

agcggcagaa gatggggcca agagtacaac ctgaccatca acaacctgca gcctgaggat     1080

atcgccacat acttctgcca agtgtacgag ttcgtggtgc ccggcaccag actggacctg     1140

aagcgggctg atgctgcacc aactgtatcc atcttcccac catccagtga gcagttaaca     1200

tctggaggtg cctcagtcgt gtgcttcttg aacaacttct accccaaaga catcaatgtc     1260

aagtggaaga ttgatggcag tgaacgacaa aatggcgtcc tgaacagttg gactgatcag     1320

gacagcaaag acagcaccta cagcatgagc agcaccctca cgttgaccaa ggacgagtat     1380

gaacgacata acagctatac ctgtgaggcc actcacaaga catcaacttc acccattgtc     1440

aagagcttca acaggaatga gtgtcgcgcg aaacgcggaa gcggagctac taacttcagc     1500

ctgctgaagc aggctggaga cgtggaggag aaccctggac ctatggactg gacctggagg     1560

atcctcttct tggtggcagc agccacagga gcccactccc aggttcagct gctgcaatct     1620

ggcgccgctg tgacaaaacc tggcgcctct gttagagtgt cctgcgaggc tagcggctac     1680

aacatcagag actacttcat ccactggtgg cggcaggctc caggacaggg acttcaatgg     1740

gtcggctgga tcaaccccaa aaccgggcag cctaacaacc ccagacagtt ccagggcaga     1800

gtgtccctga caagacacgc cagctgggac ttcgacacct tcagcttcta catggacctg     1860

aaggccctga gaagcgacga tacagccgtg tacttctgtg ctcggcagcg gtccgactac     1920

tgggacttcg acgtgtgggg cagtggaacc caagttactg tttcgtcagg tgagtcctcg     1980

aggagtggag tggggcactt tctttagatt tgtgaggaat gttccgcact agattgttta     2040

aaacttcatt tgttggaagg agagctgtct tagtgattga gtcaagggag aaaggcatct     2100

agcctcggtc tcaaaagggt agttgctgtc tagagaggtc tggtggagcc tgcaaaagtc     2160

cagctttcaa aggaacacag aagtatgtgt atggaatatt agaagatgtt gcttttactc     2220

ttaagttggt tcctaggaaa aatagttaaa tactgtgact ttaaaatgtg agagggtttt     2280

caagtactca tttttttaaa tgtccaaaat tcttgtcaat cagtttgagg tcttgtttgt     2340

gtagaactga tattacttaa agtttaaccg aggaatggga gtgaggctct ctcataacct     2400

attcagaact gacttttaac aataataaat taagtttcaa atatttttaa atgaattgag     2460

caatgttgag ttgg                                                       2474


<210>  148
<211>  2416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADN221 cassette (a human donor cassette)

<400>  148
gtaagaatgg ccactctagg gcctttgttt tctgctactg cctgtggggt ttcctgagca       60

ttgcaggttg gtcctcgggg catgttccga ggggacctgg gcggactggc caggagggga      120

cgggcactgg ggtgccttga ggatctggga gcctctgtgg attttccgat gcctttggaa      180

aatgggactc aggttgggtg cgtctgatgg agtaactgag cctgggggct tggggagcca      240

catttggacg agatgcctga acaaaccagg ggtcttagtg atggctgagg aatgtgtctc      300

aggagcggtg tctgtaggac tgcaagatcg ctgcacagca gcgaatcgtg aaatattttc      360

tttagaatta tgaggtgcgc tgtgtgtcaa cctgcatctt aaattcttta ttggctggaa      420

agagaactgt ccctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc      480

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga      540

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga      600

cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat      660

ggggtacctt ttcattcctt cctctccagt tcttctctag atggactagg tccttaacta      720

gcgaattcgg atccctgtct catgaatatg caaatcaggt gagtccatgg tggtaaatat      780

agggatgtcg acacacctca caaacttaag atctagaatg gacatgaggg tccctgctca      840

gctcctgggg ctcctgctgc tctggctctc tggagccaga tgtgacatcc agatgaccca      900

gtctccatcc tccctgtctg cctctgtggg agataccgtc actatcactt gccaagcaaa      960

cggctactta aattggtatc aacagaggcg agggaaagcc ccaaaactcc tgatctacga     1020

tgggtccaaa ttggaaagag gggtcccatc aaggtttagt ggaagaagat gggggcaaga     1080

atataatctg accatcaaca atctgcagcc cgaagacatt gcaacatatt tttgtcaagt     1140

gtatgagttt gtcgtccctg ggaccagact ggatttgaaa cgaacggtgg ctgcaccatc     1200

tgtcttcatc ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg     1260

cctgctgaat aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct     1320

ccaatcgggc aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag     1380

cctcagcagc accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg     1440

cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg     1500

tcgcgcgaaa cgcggaagcg gagctactaa cttcagcctg ctgaagcagg ctggagacgt     1560

ggaggagaac cctggaccta tggactggac ctggaggatc ctcttcttgg tggcagcagc     1620

cacaggagcc cactcccagg tccaattgtt acagtctggg gcagcggtga cgaagcccgg     1680

ggcctcagtg agagtctcct gcgaggcttc tggatacaac attcgtgact actttattca     1740

ttggtggcga caagccccag gacagggcct tcagtgggtg ggatggatca atcctaagac     1800

aggacagcca aacaatcctc gtcaatttca aggtagagtc agtctgactc gacacgcgtc     1860

gtgggacttt gacacatttt ccttttacat ggacctgaag gcactaagat cggacgacac     1920

ggccgtttat ttctgtgcgc gacagcgcag cgactattgg gatttcgacg tctggggcag     1980

tggaacccag gtcactgtct cgtcaggtga gtcctcgagg ggagtgggtg aatccagcca     2040

ggagggacgc gtagccccgg tcttgatgag agcagggttg ggggcagggg tagcccagaa     2100

acggtggctg ccgtcctgac aggggcttag ggaggctcca ggacctcagt gccttgaagc     2160

tggtttccaa gagaaaagga ttgtttatct taggaggcat gcttactgtt aaaagacagg     2220

atatgtttga agtggcttct gagaaaaatg gttaagaaaa ttatgactta aaaatgtgag     2280

agattttcaa gtatattaat ttttttaact gtccaagtat ttgaaattct tatcatttga     2340

ttaacaccca tgagtgatat gtgtctggaa ttgaggccaa agcaagctca gctaagaaat     2400

actagcacag tgctgt                                                     2416


<210>  149
<211>  2527
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADN191 cassette

<400>  149
gtaagaatgg cctctccagg tctttatttt taacctttgt tatggagttt tctgagcatt       60

gcagactaat cttggatatt tgtccctgag ggagccggct gagagaagtt gggaaataaa      120

ctgtctaggg atctcagagc ctttaggaca gattatctcc acatctttga aaaactaaga      180

atctgtgtga tggtgttggt ggagtccctg gatgatggga tagggacttt ggaggctcat      240

ttgaagaaga tgctaaaaca atcctatggc tggagggata gttggggctg tagttggaga      300

ttttcagttt ttagaataaa agtattagtt gtggaatata cttcaggacc acctctgtga      360

cagcatttat acagtatccg atgcataggg acaaactcga ctgtgccttc tagttgccag      420

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact      480

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt      540

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat      600

gctggggatg cggtgggctc tatggggtac cttttcattc cttcctctcc agttcttctc      660

tagatggact aggtccttaa ctagcgaatt cggatccctg tctcatgaat atgcaaatca      720

ggtgagtcca tggtggtaaa tatagggatg tcgacacacc tcacaaactt aagatctaga      780

cctaggatgg cgacgggttc aagaacttcc ctacttcttg catttggcct gctttgtttg      840

ccgtggttac aggagggctc ggcagacatc cagatgacac agagcccctc tacactgagc      900

gccagcgtgg gagacagagt gaccatcaca tgcaagtgcc agctgagcgt gggctacatg      960

cactggtatc agcagaagcc tggcaaggcc cctaagctgc tgatctacga cacaagcaag     1020

ctggcctctg gcgtgccctc tagattttct ggcagcggct ctggcaccga gttcaccctg     1080

acaatctcta gcctgcagcc tgacgacttc gccacctact actgcttcca aggctctggc     1140

taccccttca cattcggcgg aggcaccaag ctggaaatca agggggctga tgctgcacca     1200

actgtatcca tcttcccacc atccagtgag cagttaacat ctggaggtgc ctcagtcgtg     1260

tgcttcttga acaacttcta ccccaaagac atcaatgtca agtggaagat tgatggcagt     1320

gaacgacaaa atggcgtcct gaacagttgg actgatcagg acagcaaaga cagcacctac     1380

agcatgagca gcaccctcac gttgaccaag gacgagtatg aacgacataa cagctatacc     1440

tgtgaggcca ctcacaagac atcaacttca cccattgtca agagcttcaa caggaatgag     1500

tgtcgcgcga aacgcggaag cggagctact aacttcagcc tgctgaagca ggctggagac     1560

gtggaggaga accctggacc tatggcgacg ggttcaagaa cttccctact tcttgcattt     1620

ggcctgcttt gtttgccgtg gttacaggag ggctcggcac aagtgaccct gagagagtct     1680

ggccccgctc tggttaagcc cacacagacc ctgacactga cctgcacctt cagcggcttc     1740

agcctgagca caagcggcat gtctgtcggc tggatcagac agcctcctgg caaggctctg     1800

gaatggctgg ccgacatttg gtgggacgac aagaaggact acaaccccag cctgaagtcc     1860

agactgacca tcagcaagga caccagcaag aaccaggtgg tgctgaaagt gaccaacatg     1920

gaccctgccg acaccgccac ctactactgc gccagatcca tgatcaccaa ctggtacttc     1980

gacgtctggg gcgccggcac cacagtgaca gtttcttcta cctcctcagg taagggagtg     2040

gagtggggca ctttctttag atttgtgagg aatgttccgc actagattgt ttaaaacttc     2100

atttgttgga aggagagctg tcttagtgat tgagtcaagg gagaaaggca tctagcctcg     2160

gtctcaaaag ggtagttgct gtctagagag gtctggtgga gcctgcaaaa gtccagcttt     2220

caaaggaaca cagaagtatg tgtatggaat attagaagat gttgctttta ctcttaagtt     2280

ggttcctagg aaaaatagtt aaatactgtg actttaaaat gtgagagggt tttcaagtac     2340

tcattttttt aaatgtccaa aattcttgtc aatcagtttg aggtcttgtt tgtgtagaac     2400

tgatattact taaagtttaa ccgaggaatg ggagtgaggc tctctcataa cctattcaga     2460

actgactttt aacaataata aattaagttt caaatatttt taaatgaatt gagcaatgtt     2520

gagttgg                                                               2527


<210>  150
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Seq 29 includes both the VL and CL.  Seq 30 includes only the VH.
       VL sequence is

<400>  150
gacatccaga tgacacagag cccctctaca ctgagcgcca gcgtgggaga cagagtgacc       60

atcacatgca agtgccagct gagcgtgggc tacatgcact ggtatcagca gaagcctggc      120

aaggccccta agctgctgat ctacgacaca agcaagctgg cctctggcgt gccctctaga      180

ttttctggca gcggctctgg caccgagttc accctgacaa tctctagcct gcagcctgac      240

gacttcgcca cctactactg cttccaaggc tctggctacc ccttcacatt cggcggaggc      300

accaagctgg aaatcaag                                                    318


<210>  151
<211>  299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Seq 31 includes both the VL and CL. Seq 30 includes only the VH. 
       VL sequence is

<400>  151
gacatccaga tgacccagtc tccatcctcc ctgtctgcct ctgtgggaga taccgtcact       60

atcacttgcc aagcaaacgg ctacttaaat tggtatcaac agaggcgagg gaaagcccca      120

aaactcctga tctacgatgg gtccaaattg gaaagagggg tcccatcaag gtttagtgga      180

agaagatggg ggcaagaata taatctgacc atcaacaatc tgcagcccga agacattgca      240

acatattttt gtcaagtgta tgagtttgtc gtccctggga ccagactgga tttgaaacg       299


<210>  152
<211>  155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated IgH promoter

<400>  152
ggtacctttt cattccttcc tctccagttc ttctctagat ggactaggtc cttaactagc       60

gaattcggat ccctgtctca tgaatatgca aatcaggtga gtccatggtg gtaaatatag      120

ggatgtcgac acacctcaca aacttaagat ctaga                                 155


<210>  153
<211>  1587
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fragment for the 3BNC117-opt donor

<400>  153
ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt       60

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca      120

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga      180

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg ggtacctttt      240

cattccttcc tctccagttc ttctctagat ggactaggtc cttaactagc gaattcggat      300

ccctgtctca tgaatatgca aatcaggtga gtccatggtg gtaaatatag ggatgtcgac      360

acacctcaca aacttaagat ctagaatgga catgagggtc cctgctcagc tcctggggct      420

cctgctgctc tggctctctg gagccagatg tgacatccag atgacacaga gccctagcag      480

cctgtctgcc agcgtgggag acaccgtgac aattacctgc caagctaacg gctacctgaa      540

ctggtatcag cagagaagag gcaaggcccc taagctgctg atctacgacg gcagcaagct      600

ggaaagaggc gtgccctcta gattcagcgg cagaagatgg ggccaagagt acaacctgac      660

catcaacaac ctgcagcctg aggatatcgc cacatacttc tgccaagtgt acgagttcgt      720

ggtgcccggc accagactgg acctgaagcg ggctgatgct gcaccaactg tatccatctt      780

cccaccatcc agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa      840

cttctacccc aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg      900

cgtcctgaac agttggactg atcaggacag caaagacagc acctacagca tgagcagcac      960

cctcacgttg accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca     1020

caagacatca acttcaccca ttgtcaagag cttcaacagg aatgagtgtc gcgcgaaacg     1080

cggaagcgga gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc     1140

tggacctatg gactggacct ggaggatcct cttcttggtg gcagcagcca caggagccca     1200

ctcccaggtt cagctgctgc aatctggcgc cgctgtgaca aaacctggcg cctctgttag     1260

agtgtcctgc gaggctagcg gctacaacat cagagactac ttcatccact ggtggcggca     1320

ggctccagga cagggacttc aatgggtcgg ctggatcaac cccaaaaccg ggcagcctaa     1380

caaccccaga cagttccagg gcagagtgtc cctgacaaga cacgccagct gggacttcga     1440

caccttcagc ttctacatgg acctgaaggc cctgagaagc gacgatacag ccgtgtactt     1500

ctgtgctcgg cagcggtccg actactggga cttcgacgtg tggggcagtg gaacccaagt     1560

tactgtttcg tcaggtgagt cctcgag                                         1587


<210>  154
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NATIVE ANTIBODY

<400>  154

Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala Ser 
1               5                   10                  15      


Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala Pro 
            20                  25                  30          


Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly Gln 
        35                  40                  45              


Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp Asp 
    50                  55                  60                  


Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp 
                85                  90                  95      


Phe Asp Val Trp Gly Ser 
            100         


<210>  155
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  155

Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala Ser 
1               5                   10                  15      


Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala Pro 
            20                  25                  30          


Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly Gln 
        35                  40                  45              


Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp Asp 
    50                  55                  60                  


Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Phe Cys Thr Arg Gln Arg Ser Asp Tyr Trp Asp 
                85                  90                  95      


Phe Asp Val Trp Gly Ser 
            100         


<210>  156
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  156

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Arg Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  157
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  157

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Gly Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  158
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  158

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Gly Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  159
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  159

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  160
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  160

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Leu Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  161
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  161

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Gly Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  162
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  162

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  163
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  163

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Gly Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  164
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  164

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Ala Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  165
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  165

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Gly Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  166
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  166

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  167
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  167

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Ala Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  168
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  168

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Ala Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  169
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  169

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Gly Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  170
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  170

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Gly Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  171
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  171

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Ala Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  172
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  172

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Arg Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  173
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  173

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Gly Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  174
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  174

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Ser Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  175
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  175

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Gly Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  176
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  176

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  177
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  177

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Ala Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  178
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  178

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Gly Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  179
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  179

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Arg Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  180
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  180

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Gly Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  181
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  181

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  182
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  182

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Gly Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  183
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  183

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Ala Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  184
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  184

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg His Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  185
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  185

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Thr Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  186
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  186

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Ala Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  187
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  187

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg His Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  188
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  188

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Pro Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  189
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  189

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Ser Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  190
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  190

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Ala Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  191
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  191

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg His Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  192
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  192

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Thr Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  193
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  193

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Phe Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  194
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  194

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Ala Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  195
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  195

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Cys Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  196
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  196

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Arg Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  197
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  197

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Arg Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  198
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  198

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Gly Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  199
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  199

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Ser Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  200
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  200

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Ser Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  201
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  201

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Ala Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  202
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  202

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Thr Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  203
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  203

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg His Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  204
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  204

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asn Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  205
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  205

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Arg Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  206
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  206

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg His Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  207
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  207

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Ala Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  208
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  208

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Phe Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  209
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  209

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Gly Val Trp Gly Ser 
            100             


<210>  210
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  210

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Thr Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  211
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  211

Ala Thr Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  212
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  212

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Arg Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  213
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  213

Ala Ala Val Ile Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  214
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  214

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Arg 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  215
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  215

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Lys Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  216
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  216

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Met Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Leu Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  217
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  217

Ala Ala Val Thr Lys Pro Gly Ala Pro Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  218
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  218

Asp Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  219
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  219

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Gly Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  220
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  220

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Arg Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Thr Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  221
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  221

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Thr His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  222
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  222

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Ala Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  223
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  223

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Arg Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Ala Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  224
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  224

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Arg Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asn Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  225
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  225

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  226
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  226

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Ala Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  227
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  227

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Gly Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  228
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  228

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Ser Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  229
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  229

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Ala Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  230
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  230

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Arg Arg Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  231
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  231

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Arg Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  232
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  232

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Arg Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  233
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  233

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Arg Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Asn Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Leu Tyr Met Ala Leu Lys Ala Leu Arg Gly 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Trp Ala Arg Arg Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  234
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  234

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Leu Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  235
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  235

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg His Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  236
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  236

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Arg 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  237
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  237

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Ala Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  238
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  238

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Ala Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  239
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  239

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  240
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  240

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Ser Ser 
            100             


<210>  241
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  241

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Ser Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  242
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  242

Ala Ala Gly Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Pro Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Arg 
            100             


<210>  243
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  243

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Pro Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  244
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  244

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly His Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  245
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  245

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  246
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  246

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Gly Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  247
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  247

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Gly Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  248
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  248

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Ala Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  249
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  249

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Cys Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  250
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  250

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Arg Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  251
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  251

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Ala Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  252
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  252

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Ala Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  253
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  253

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Ala Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  254
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  254

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Phe Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  255
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  255

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly His Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  256
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  256

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Gly Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  257
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  257

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Ala Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  258
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  258

Ala Ala Gly Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  259
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  259

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Arg Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  260
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  260

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Ser Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  261
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  261

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Ala Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  262
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  262

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  263
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  263

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Pro Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  264
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  264

Ala Ala Ala Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  265
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VARIANT

<400>  265

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Thr Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  266
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  266

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Ser Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  267
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  267

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Gly Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  268
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  268

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Gly Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  269
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  269

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Ala Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  270
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  270

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Arg 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  271
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  271

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Thr Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  272
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  272

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Arg Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  273
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  273

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Arg Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Cys Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  274
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant

<400>  274

Ala Ala Val Thr Lys Pro Gly Ala Ser Val Arg Val Ser Cys Glu Ala 
1               5                   10                  15      


Ser Gly Tyr Asn Ile Pro Asp Tyr Phe Ile His Trp Trp Arg Gln Ala 
            20                  25                  30          


Pro Gly Gln Gly Leu Gln Trp Val Gly Trp Ile Asn Pro Lys Thr Gly 
        35                  40                  45              


Gln Pro Asn Asn Pro Arg Gln Phe Gln Gly Arg Val Ser Leu Thr Trp 
    50                  55                  60                  


Asp Phe Asp Thr Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp 
                85                  90                  95      


Asp Phe Asp Val Trp Gly Ser 
            100             


<210>  275
<211>  2274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADN174 cassette

<400>  275
gtaagaatgg cctctccagg tctttatttt taacctttgt tatggagttt tctgagcatt       60

gcagactaat cttggatatt tgtccctgag ggagccggct gagagaagtt gggaaataaa      120

ctgtctaggg atctcagagc ctttaggaca gattatctcc acatctttga aaaactaaga      180

atctgtgtga tggtgttggt ggagtccctg gatgatggga tagggacttt ggaggctcat      240

ttgaagaaga tgctaaaaca atcctatggc tggagggata gttggggctg tagttggaga      300

ttttcagttt ttagaataaa agtattagtt gtggaatata cttcaggacc acctctgtga      360

cagcatttat acagtatccg atgcataggg acaaacgtgt agagggatct cctgtctgac      420

aggaggcaag aagacagatt cttacccctc catttctctt ttatccctct ctggtcctca      480

gagagtcagt ccttcccaaa tgcgcgcgaa acgcggaagc ggagctacta acttcagcct      540

gctgaagcag gctggagacg tggaggagaa ccctggacct atggacatga gggtccctgc      600

tcagctcctg gggctcctgc tgctctggct ctctggagcc agatgtgaca tccagatgac      660

ccagtctcca tcctccctgt ctgcctctgt gggagatacc gtcactatca cttgccaagc      720

aaacggctac ttaaattggt atcaacagag gcgagggaaa gccccaaaac tcctgatcta      780

cgatgggtcc aaattggaaa gaggggtccc atcaaggttt agtggaagaa gatgggggca      840

agaatataat ctgaccatca acaatctgca gcccgaagac attgcaacat atttttgtca      900

agtgtatgag tttgtcgtcc ctgggaccag actggatttg aaacgggctg atgctgcacc      960

aactgtatcc atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt     1020

gtgcttcttg aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag     1080

tgaacgacaa aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta     1140

cagcatgagc agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac     1200

ctgtgaggcc actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga     1260

gtgtcgcgcg aaacgcggaa gcggagctac taacttcagc ctgctgaagc aggctggaga     1320

cgtggaggag aaccctggac ctatggactg gacctggagg atcctcttct tggtggcagc     1380

agccacagga gcccactccc aggtccaatt gttacagtct ggggcagcgg tgacgaagcc     1440

cggggcctca gtgagagtct cctgcgaggc ttctggatac aacattcgtg actactttat     1500

tcattggtgg cgacaagccc caggacaggg ccttcagtgg gtgggatgga tcaatcctaa     1560

gacaggacag ccaaacaatc ctcgtcaatt tcaaggtaga gtcagtctga ctcgacacgc     1620

gtcgtgggac tttgacacat tttcctttta catggacctg aaggcactaa gatcggacga     1680

cacggccgtt tatttctgtg cgcgacagcg cagcgactat tgggatttcg acgtctgggg     1740

cagtggaacc caggtcactg tctcgtcagg tgagtcctcg aggagtggag tggggcactt     1800

tctttagatt tgtgaggaat gttccgcact agattgttta aaacttcatt tgttggaagg     1860

agagctgtct tagtgattga gtcaagggag aaaggcatct agcctcggtc tcaaaagggt     1920

agttgctgtc tagagaggtc tggtggagcc tgcaaaagtc cagctttcaa aggaacacag     1980

aagtatgtgt atggaatatt agaagatgtt gcttttactc ttaagttggt tcctaggaaa     2040

aatagttaaa tactgtgact ttaaaatgtg agagggtttt caagtactca tttttttaaa     2100

tgtccaaaat tcttgtcaat cagtttgagg tcttgtttgt gtagaactga tattacttaa     2160

agtttaaccg aggaatggga gtgaggctct ctcataacct attcagaact gacttttaac     2220

aataataaat taagtttcaa atatttttaa atgaattgag caatgttgag ttgg           2274


<210>  276
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primers P2A 174 R

<400>  276
catgtccata ggtccagggt tctcctc                                           27


<210>  277
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the mIgHJ1 F1 primer

<400>  277
gcacagggac cacggtcac                                                    19


<210>  278
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHJ2 F1

<400>  278
gccaaggcac cactctcaca g                                                 21


<210>  279
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHJ3 F1

<400>  279
gactctggtc actgtctctg cag                                               23


<210>  280
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHJ4 F1

<400>  280
ggtcaaggaa cctcagtcac cg                                                22


<210>  281
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A F1

<400>  281
gagacgtgga ggagaaccct g                                                 21


<210>  282
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgHM CH2 R1

<400>  282
cgtggtggga cgaacacatt tac                                               23


<210>  283
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequencing of 3BNC117 Variable heavy CDR1 following SHM 
       optimization in mice

<400>  283

Asp Tyr Phe Ile His 
1               5   


<210>  284
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequencing of 3BNC117 Variable heavy CDR2 following SHM 
       optimization in mice


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  may be substituted by Leu

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  may be substituted by Phe or Val

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  may be substituted by Lys

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  may be substituted by Leu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  may be substituted by Thr , Arg, Met or Asn

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  may be substituted by Lys, Pro, Asn, Gln or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  may be substituted by Lys, Pro, His, Arg, Thr, Leu or Trp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  may be substituted by Gln, His, Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  may be substituted by Lys or Thr

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  may be substituted by His, Thr, Met, Lys, Ser, Pro or Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  may be substituted by His, Ser, Leu or Arg

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  may be substituted by Ser, Gly, Cys, Leu, His or Val

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  may be substituted by Lys or His

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  may be substituted by Val, Leu or Cys

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  may be substituted by Lys, Pro, His or Leu

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  may be substituted by Val or Cys

<400>  284

Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  285
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequencing of 3BNC117 Variable heavy CDR3 following SHM 
       optimization in mice

<400>  285

Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
1               5                   10  


