                         SEQUENCE LISTING

<110>  Anbition srl
 
<120>  Peptidi ed usi medici correlati

<130>  21.A0615.12.WO.1

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  7123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFR1 umano intero

<400>  1
atcgaggtcc gcgggaggct cggagcgcgc caggcggaca ctcctctcgg ctcctccccg       60

gcagcggcgg cggctcggag cgggctccgg ggctcgggtg cagcggccag cgggcgcctg      120

gcggcgagga ttacccgggg aagtggttgt ctcctggctg gagccgcgag acgggcgctc      180

agggcgcggg gccggcggcg gcgaacgaga ggacggactc tggcggccgg gtcgttggcc      240

gcggggagcg cgggcaccgg gcgagcaggc cgcgtcgcgc tcaccatggt cagctactgg      300

gacaccgggg tcctgctgtg cgcgctgctc agctgtctgc ttctcacagg atctagttca      360

ggttcaaaat taaaagatcc tgaactgagt ttaaaaggca cccagcacat catgcaagca      420

ggccagacac tgcatctcca atgcaggggg gaagcagccc ataaatggtc tttgcctgaa      480

atggtgagta aggaaagcga aaggctgagc ataactaaat ctgcctgtgg aagaaatggc      540

aaacaattct gcagtacttt aaccttgaac acagctcaag caaaccacac tggcttctac      600

agctgcaaat atctagctgt acctacttca aagaagaagg aaacagaatc tgcaatctat      660

atatttatta gtgatacagg tagacctttc gtagagatgt acagtgaaat ccccgaaatt      720

atacacatga ctgaaggaag ggagctcgtc attccctgcc gggttacgtc acctaacatc      780

actgttactt taaaaaagtt tccacttgac actttgatcc ctgatggaaa acgcataatc      840

tgggacagta gaaagggctt catcatatca aatgcaacgt acaaagaaat agggcttctg      900

acctgtgaag caacagtcaa tgggcatttg tataagacaa actatctcac acatcgacaa      960

accaatacaa tcatagatgt ccaaataagc acaccacgcc cagtcaaatt acttagaggc     1020

catactcttg tcctcaattg tactgctacc actcccttga acacgagagt tcaaatgacc     1080

tggagttacc ctgatgaaaa aaataagaga gcttccgtaa ggcgacgaat tgaccaaagc     1140

aattcccatg ccaacatatt ctacagtgtt cttactattg acaaaatgca gaacaaagac     1200

aaaggacttt atacttgtcg tgtaaggagt ggaccatcat tcaaatctgt taacacctca     1260

gtgcatatat atgataaagc attcatcact gtgaaacatc gaaaacagca ggtgcttgaa     1320

accgtagctg gcaagcggtc ttaccggctc tctatgaaag tgaaggcatt tccctcgccg     1380

gaagttgtat ggttaaaaga tgggttacct gcgactgaga aatctgctcg ctatttgact     1440

cgtggctact cgttaattat caaggacgta actgaagagg atgcagggaa ttatacaatc     1500

ttgctgagca taaaacagtc aaatgtgttt aaaaacctca ctgccactct aattgtcaat     1560

gtgaaacccc agatttacga aaaggccgtg tcatcgtttc cagacccggc tctctaccca     1620

ctgggcagca gacaaatcct gacttgtacc gcatatggta tccctcaacc tacaatcaag     1680

tggttctggc acccctgtaa ccataatcat tccgaagcaa ggtgtgactt ttgttccaat     1740

aatgaagagt cctttatcct ggatgctgac agcaacatgg gaaacagaat tgagagcatc     1800

actcagcgca tggcaataat agaaggaaag aataagatgg ctagcacctt ggttgtggct     1860

gactctagaa tttctggaat ctacatttgc atagcttcca ataaagttgg gactgtggga     1920

agaaacataa gcttttatat cacagatgtg ccaaatgggt ttcatgttaa cttggaaaaa     1980

atgccgacgg aaggagagga cctgaaactg tcttgcacag ttaacaagtt cttatacaga     2040

gacgttactt ggattttact gcggacagtt aataacagaa caatgcacta cagtattagc     2100

aagcaaaaaa tggccatcac taaggagcac tccatcactc ttaatcttac catcatgaat     2160

gtttccctgc aagattcagg cacctatgcc tgcagagcca ggaatgtata cacaggggaa     2220

gaaatcctcc agaagaaaga aattacaatc agagatcagg aagcaccata cctcctgcga     2280

aacctcagtg atcacacagt ggccatcagc agttccacca ctttagactg tcatgctaat     2340

ggtgtccccg agcctcagat cacttggttt aaaaacaacc acaaaataca acaagagcct     2400

ggaattattt taggaccagg aagcagcacg ctgtttattg aaagagtcac agaagaggat     2460

gaaggtgtct atcactgcaa agccaccaac cagaagggct ctgtggaaag ttcagcatac     2520

ctcactgttc aaggaacctc ggacaagtct aatctggagc tgatcactct aacatgcacc     2580

tgtgtggctg cgactctctt ctggctccta ttaaccctct ttatccgaaa aatgaaaagg     2640

tcttcttctg aaataaagac tgactaccta tcaattataa tggacccaga tgaagttcct     2700

ttggatgagc agtgtgagcg gctcccttat gatgccagca agtgggagtt tgcccgggag     2760

agacttaaac tgggcaaatc acttggaaga ggggcttttg gaaaagtggt tcaagcatca     2820

gcatttggca ttaagaaatc acctacgtgc cggactgtgg ctgtgaaaat gctgaaagag     2880

ggggccacgg ccagcgagta caaagctctg atgactgagc taaaaatctt gacccacatt     2940

ggccaccatc tgaacgtggt taacctgctg ggagcctgca ccaagcaagg agggcctctg     3000

atggtgattg ttgaatactg caaatatgga aatctctcca actacctcaa gagcaaacgt     3060

gacttatttt ttctcaacaa ggatgcagca ctacacatgg agcctaagaa agaaaaaatg     3120

gagccaggcc tggaacaagg caagaaacca agactagata gcgtcaccag cagcgaaagc     3180

tttgcgagct ccggctttca ggaagataaa agtctgagtg atgttgagga agaggaggat     3240

tctgacggtt tctacaagga gcccatcact atggaagatc tgatttctta cagttttcaa     3300

gtggccagag gcatggagtt cctgtcttcc agaaagtgca ttcatcggga cctggcagcg     3360

agaaacattc ttttatctga gaacaacgtg gtgaagattt gtgattttgg ccttgcccgg     3420

gatatttata agaaccccga ttatgtgaga aaaggagata ctcgacttcc tctgaaatgg     3480

atggctcctg aatctatctt tgacaaaatc tacagcacca agagcgacgt gtggtcttac     3540

ggagtattgc tgtgggaaat cttctcctta ggtgggtctc catacccagg agtacaaatg     3600

gatgaggact tttgcagtcg cctgagggaa ggcatgagga tgagagctcc tgagtactct     3660

actcctgaaa tctatcagat catgctggac tgctggcaca gagacccaaa agaaaggcca     3720

agatttgcag aacttgtgga aaaactaggt gatttgcttc aagcaaatgt acaacaggat     3780

ggtaaagact acatcccaat caatgccata ctgacaggaa atagtgggtt tacatactca     3840

actcctgcct tctctgagga cttcttcaag gaaagtattt cagctccgaa gtttaattca     3900

ggaagctctg atgatgtcag atacgtaaat gctttcaagt tcatgagcct ggaaagaatc     3960

aaaacctttg aagaactttt accgaatgcc acctccatgt ttgatgacta ccagggcgac     4020

agcagcactc tgttggcctc tcccatgctg aagcgcttca cctggactga cagcaaaccc     4080

aaggcctcgc tcaagattga cttgagagta accagtaaaa gtaaggagtc ggggctgtct     4140

gatgtcagca ggcccagttt ctgccattcc agctgtgggc acgtcagcga aggcaagcgc     4200

aggttcacct acgaccacgc tgagctggaa aggaaaatcg cgtgctgctc cccgccccca     4260

gactacaact cggtggtcct gtactccacc ccacccatct agagtttgac acgaagcctt     4320

atttctagaa gcacatgtgt atttataccc ccaggaaact agcttttgcc agtattatgc     4380

atatataagt ttacaccttt atctttccat gggagccagc tgctttttgt gattttttta     4440

atagtgcttt tttttttttg actaacaaga atgtaactcc agatagagaa atagtgacaa     4500

gtgaagaaca ctactgctaa atcctcatgt tactcagtgt tagagaaatc cttcctaaac     4560

ccaatgactt ccctgctcca acccccgcca cctcagggca cgcaggacca gtttgattga     4620

ggagctgcac tgatcaccca atgcatcacg taccccactg ggccagccct gcagcccaaa     4680

acccagggca acaagcccgt tagccccagg gatcactggc tggcctgagc aacatctcgg     4740

gagtcctcta gcaggcctaa gacatgtgag gaggaaaagg aaaaaaagca aaaagcaagg     4800

gagaaaagag aaaccgggag aaggcatgag aaagaatttg agacgcacca tgtgggcacg     4860

gagggggacg gggctcagca atgccatttc agtggcttcc cagctctgac ccttctacat     4920

ttgagggccc agccaggagc agatggacag cgatgagggg acattttctg gattctggga     4980

ggcaagaaaa ggacaaatat cttttttgga actaaagcaa attttagaac tttacctatg     5040

gaagtggttc tatgtccatt ctcattcgtg gcatgttttg atttgtagca ctgagggtgg     5100

cactcaactc tgagcccata cttttggctc ctctagtaag atgcactgaa aacttagcca     5160

gagttaggtt gtctccaggc catgatggcc ttacactgaa aatgtcacat tctattttgg     5220

gtattaatat atagtccaga cacttaactc aatttcttgg tattattctg ttttgcacag     5280

ttagttgtga aagaaagctg agaagaatga aaatgcagtc ctgaggagag gagttttctc     5340

catatcaaaa cgagggctga tggaggaaaa aggtcaataa ggtcaaggga aaaccccgtc     5400

tctataccaa ccaaaccaat tcaccaacac agttgggacc caaaacacag gaagtcagtc     5460

acgtttcctt ttcatttaat ggggattcca ctatctcaca ctaatctgaa aggatgtgga     5520

agagcattag ctggcgcata ttaagcactt taagctcctt gagtaaaaag gtggtatgta     5580

atttatgcaa ggtatttctc cagttgggac tcaggatatt agttaatgag ccatcactag     5640

aagaaaagcc cattttcaac tgctttgaaa cttgcctggg gtctgagcat gatgggaata     5700

gggagacagg gtaggaaagg gcgcctactc ttcagggtct aaagatcaag tgggccttgg     5760

atcgctaagc tggctctgtt tgatgctatt tatgcaagtt agggtctatg tatttatgat     5820

gtctgcacct tctgcagcca gtcagaagct ggagaggcaa cagtggattg ctgcttcttg     5880

gggagaagag tatgcttcct tttatccatg taatttaact gtagaacctg agctctaagt     5940

aaccgaagaa tgtatgcctc tgttcttatg tgccacatcc ttgtttaaag gctctctgta     6000

tgaagagatg ggaccgtcat cagcacattc cctagtgagc ctactggctc ctggcagcgg     6060

cttttgtgga agactcacta gccagaagag aggagtggga cagtcctctc caccaagatc     6120

taaatccaaa caaaagcagg ctagagccag aagagaggac aaatctttgt tcttcctctt     6180

ctttacatac gcaaaccacc tgtgacagct ggcaatttta taaatcaggt aactggaagg     6240

aggttaaaca cagaaaaaag aagacctcag tcaattctct actttttttt ttttttccaa     6300

atcagataat agcccagcaa atagtgataa caaataaaac cttagctatt catgtcttga     6360

tttcaataat taattcttaa tcattaagag accataataa atactccttt tcaagagaaa     6420

agcaaaacca ttagaattgt tactcagctc cttcaaactc aggtttgtag catacatgag     6480

tccatccatc agtcaaagaa tggttccatc tggagtctta atgtagaaag aaaaatggag     6540

acttgtaata atgagctagt tacaaagtgc ttgttcatta aaatagcact gaaaattgaa     6600

acatgaatta actgataata ttccaatcat ttgccattta tgacaaaaat ggttggcact     6660

aacaaagaac gagcacttcc tttcagagtt tctgagataa tgtacgtgga acagtctggg     6720

tggaatgggg ctgaaaccat gtgcaagtct gtgtcttgtc agtccaagaa gtgacaccga     6780

gatgttaatt ttagggaccc gtgccttgtt tcctagccca caagaatgca aacatcaaac     6840

agatactcgc tagcctcatt taaattgatt aaaggaggag tgcatctttg gccgacagtg     6900

gtgtaactgt atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgggt gtatgtgtgt     6960

tttgtgcata actatttaag gaaactggaa ttttaaagtt acttttatac aaaccaagaa     7020

tatatgctac agatataaga cagacatggt ttggtcctat atttctagtc atgatgaatg     7080

tattttgtat accatcttca tataataaac ttccaaaaac aca                       7123


<210>  2
<211>  1338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGFR1 umano intero

<400>  2

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Phe Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile  Ser Tyr Ser Phe Gln  Val Ala Arg 
        995                 1000                 1005             


Gly Met  Glu Phe Leu Ser Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1010                 1015                 1020             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Asn Asn Val  Val Lys Ile 
    1025                 1030                 1035             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asn  Pro Asp Tyr 
    1040                 1045                 1050             


Val Arg  Lys Gly Asp Thr Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1055                 1060                 1065             


Glu Ser  Ile Phe Asp Lys Ile  Tyr Ser Thr Lys Ser  Asp Val Trp 
    1070                 1075                 1080             


Ser Tyr  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Gly Ser 
    1085                 1090                 1095             


Pro Tyr  Pro Gly Val Gln Met  Asp Glu Asp Phe Cys  Ser Arg Leu 
    1100                 1105                 1110             


Arg Glu  Gly Met Arg Met Arg  Ala Pro Glu Tyr Ser  Thr Pro Glu 
    1115                 1120                 1125             


Ile Tyr  Gln Ile Met Leu Asp  Cys Trp His Arg Asp  Pro Lys Glu 
    1130                 1135                 1140             


Arg Pro  Arg Phe Ala Glu Leu  Val Glu Lys Leu Gly  Asp Leu Leu 
    1145                 1150                 1155             


Gln Ala  Asn Val Gln Gln Asp  Gly Lys Asp Tyr Ile  Pro Ile Asn 
    1160                 1165                 1170             


Ala Ile  Leu Thr Gly Asn Ser  Gly Phe Thr Tyr Ser  Thr Pro Ala 
    1175                 1180                 1185             


Phe Ser  Glu Asp Phe Phe Lys  Glu Ser Ile Ser Ala  Pro Lys Phe 
    1190                 1195                 1200             


Asn Ser  Gly Ser Ser Asp Asp  Val Arg Tyr Val Asn  Ala Phe Lys 
    1205                 1210                 1215             


Phe Met  Ser Leu Glu Arg Ile  Lys Thr Phe Glu Glu  Leu Leu Pro 
    1220                 1225                 1230             


Asn Ala  Thr Ser Met Phe Asp  Asp Tyr Gln Gly Asp  Ser Ser Thr 
    1235                 1240                 1245             


Leu Leu  Ala Ser Pro Met Leu  Lys Arg Phe Thr Trp  Thr Asp Ser 
    1250                 1255                 1260             


Lys Pro  Lys Ala Ser Leu Lys  Ile Asp Leu Arg Val  Thr Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Ser Gly Leu Ser  Asp Val Ser Arg Pro  Ser Phe Cys 
    1280                 1285                 1290             


His Ser  Ser Cys Gly His Val  Ser Glu Gly Lys Arg  Arg Phe Thr 
    1295                 1300                 1305             


Tyr Asp  His Ala Glu Leu Glu  Arg Lys Ile Ala Cys  Cys Ser Pro 
    1310                 1315                 1320             


Pro Pro  Asp Tyr Asn Ser Val  Val Leu Tyr Ser Thr  Pro Pro Ile 
    1325                 1330                 1335             


<210>  3
<211>  1626
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFR1 umano solubile

<400>  3
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggttc aaaattaaaa gatcctgaac tgagtttaaa aggcacccag      120

cacatcatgc aagcaggcca gacactgcat ctccaatgca ggggggaagc agcccataaa      180

tggtctttgc ctgaaatggt gagtaaggaa agcgaaaggc tgagcataac taaatctgcc      240

tgtggaagaa atggcaaaca attctgcagt actttaacct tgaacacagc tcaagcaaac      300

cacactggct tctacagctg caaatatcta gctgtaccta cttcaaagaa gaaggaaaca      360

gaatctgcaa tctatatatt tattagtgat acaggtagac ctttcgtaga gatgtacagt      420

gaaatccccg aaattataca catgactgaa ggaagggagc tcgtcattcc ctgccgggtt      480

acgtcaccta acatcactgt tactttaaaa aagtttccac ttgacacttt gatccctgat      540

ggaaaacgca taatctggga cagtagaaag ggcttcatca tatcaaatgc aacgtacaaa      600

gaaatagggc ttctgacctg tgaagcaaca gtcaatgggc atttgtataa gacaaactat      660

ctcacacatc gacaaaccaa tacaatcata gatgtccaaa taagcacacc acgcccagtc      720

aaattactta gaggccatac tcttgtcctc aattgtactg ctaccactcc cttgaacacg      780

agagttcaaa tgacctggag ttaccctgat gaaaaaaata agagagcttc cgtaaggcga      840

cgaattgacc aaagcaattc ccatgccaac atattctaca gtgttcttac tattgacaaa      900

atgcagaaca aagacaaagg actttatact tgtcgtgtaa ggagtggacc atcattcaaa      960

tctgttaaca cctcagtgca tatatatgat aaagcattca tcactgtgaa acatcgaaaa     1020

cagcaggtgc ttgaaaccgt agctggcaag cggtcttacc ggctctctat gaaagtgaag     1080

gcatttccct cgccggaagt tgtatggtta aaagatgggt tacctgcgac tgagaaatct     1140

gctcgctatt tgactcgtgg ctactcgtta attatcaagg acgtaactga agaggatgca     1200

gggaattata caatcttgct gagcataaaa cagtcaaatg tgtttaaaaa cctcactgcc     1260

actctaattg tcaatgtgaa accccagatt tacgaaaagg ccgtgtcatc gtttccagac     1320

ccggctctct acccactggg cagcagacaa atcctgactt gtaccgcata tggtatccct     1380

caacctacaa tcaagtggtt ctggcacccc tgtaaccata atcattccga agcaaggtgt     1440

gacttttgtt ccaataatga agagtccttt atcctggatg ctgacagcaa catgggaaac     1500

agaattgaga gcatcactca gcgcatggca ataatagaag gaaagaataa gcttccacca     1560

gctaacagtt ctttcatgtt gccacctaca agcttctctt ccaactactt ccatttcctt     1620

ccgtga                                                                1626


<210>  4
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGFR1 umano solubile

<400>  4

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Leu Pro Pro Ala Asn Ser Ser Phe Met Leu Pro 
        515                 520                 525             


Pro Thr Ser Phe Ser Ser Asn Tyr Phe His Phe Leu Pro 
    530                 535                 540     


