                         SEQUENCE LISTING

<110>  Virolutions Biotech GmbH
 
<120>  Method for producing an antitumoral arenavirus as well as 
       arenavirus mutants

<130>  VIR16633PCT

<150>  DE 10 2018 215 551.8
<151>  2018-09-12

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  498
<212>  PRT
<213>  Lymphocytic choriomeningitis virus


<220>
<221>  MISC_FEATURE
<223>  Lymphocytic choriomeningitis virus Mutant p52 Glycoprotein; ssrna
       ambisense-strand viruses; arenaviridae; arenavirus; old world 
       arenaviruses

<400>  1

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Asn Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Ser Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Leu Asn His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn His Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Ser Phe Ser Asp 
                165                 170                 175     


Pro Gln Ser Ala Met Ser Gln Cys Trp Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Ala Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Arg 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Phe Ala Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Gln Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Val Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Ile Trp Lys 
                485                 490                 495     


Arg Arg 
        


<210>  2
<211>  1497
<212>  DNA
<213>  Lymphocytic choriomeningitis virus


<220>
<221>  MISC_FEATURE
<223>  Lymphocytic choriomeningitis virus Mutant p52 Glycoprotein; ssrna
       ambisense-strand viruses; arenaviridae; arenavirus; old world 
       arenaviruses

<400>  2
atgggtcaga ttgtgacaat gtttgaggct ttgcctcaca tcattgatga ggtcatcaac       60

attgtcatta ttgtgctcat tataatcacg agcatcaaag ctgtgtacaa tttcgccacc      120

tgtgggatat tagcactggt cagcttcctt tttttggctg gtaggtcctg tggcatgtac      180

ggccttaatg gtcccgacat ctataaaggg gtttaccagt tcaaatcagt ggagtttgat      240

atgtctcact taaatctgac gatgcccaat gcgtgctcag ccaacaactc tcatcactac      300

atcagtatgg gaagctctgg actggagcta actttcacta acgactccat ccttaatcac      360

aatttttgca acttaacctc cgctttcaac aaaaagactt ttgaccatac actcatgagt      420

atagtctcga gtctgcacct cagtattaga gggaattcca accacaaagc agtgtcttgt      480

gattttaaca atggcatcac cattcaatac aacttgtcat tttcggaccc acagagcgct      540

atgagccagt gttggacttt cagaggtaga gtcttggaca tgtttagaac tgcctttgga      600

ggaaaataca tgagaagtgg ctggggctgg gcaggttcag atggcaagac cacttggtgc      660

agccaaacaa gctatcagta cctaatcata caaaacagga cttgggaaaa ccactgtaga      720

tatgcaggcc cttttgggat gtctagaatc ctctttgctc aggaaaagac aaagtttctc      780

actaggagac ttgcaggcac attcacctgg accctgtcag actcctcagg agtagaaaat      840

ccaggtggtt attgcctgac caaatggatg atccttgctg cagagctcaa atgttttggg      900

aatacagctg ttgcaaaatg taatgtcaat catgatgaag agttctgtga catgctacga      960

ctaattgatt acaacaaggc cgccctgagt aagttcaagc aagatgtaga gtctgccttg     1020

catgtattca aaacaacagt aaattctctg atttccgatc agctgttgat gaggaatcat     1080

ctaagagatc taatgggggt accatactgt aattactcaa agttctggta tctggaacat     1140

gctaagactg gtgagactag tgtacccaag tgctggcttg tcactaatgg ctcctacttg     1200

aatgagaccc actttagtga tcaaatcgaa caagaagcag ataacatgat cacagagatg     1260

ttgaggaagg actacataaa aagacaaggg agtactcctt tagccttaat ggatcttttg     1320

atgttttcaa catcagcata tctaatcagc atctttctgc atcttgtgaa gataccaaca     1380

catagacaca taaagggcgg ttcatgtcca aagccacacc gcttgaccaa caaggggatc     1440

tgtagttgtg gtgcattcaa ggtgcctggt gtaaaaacta tctggaaaag acgctga        1497


<210>  3
<211>  498
<212>  PRT
<213>  Lymphocytic choriomeningitis virus


<220>
<221>  MISC_FEATURE
<223>  Lymphocytic choriomeningitis virus Mutant p42 Glycoprotein; ssrna
       ambisense-strand viruses; arenaviridae; arenavirus; old world 
       arenaviruses

<400>  3

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Asn Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Ser Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Leu Asn His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn His Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Ser Phe Ser Asp 
                165                 170                 175     


Pro Gln Ser Ala Met Ser Gln Cys Arg Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Ala Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Arg 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Phe Ala Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Gln Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Val Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Ile Trp Lys 
                485                 490                 495     


Arg Arg 
        


<210>  4
<211>  1497
<212>  DNA
<213>  Lymphocytic choriomeningitis virus


<220>
<221>  MISC_FEATURE
<223>  Lymphocytic choriomeningitis virus Mutant p42 Glycoprotein; ssrna
       ambisense-strand viruses; arenaviridae; arenavirus; old world 
       arenaviruses

<400>  4
atgggtcaga ttgtgacaat gtttgaggct ttgcctcaca tcattgatga ggtcatcaac       60

attgtcatta ttgtgctcat tataatcacg agcatcaaag ctgtgtacaa tttcgccacc      120

tgtgggatat tagcactggt cagcttcctt tttttggctg gtaggtcctg tggcatgtac      180

ggccttaatg gtcccgacat ctataaaggg gtttaccagt tcaaatcagt ggagtttgat      240

atgtctcact taaatctgac gatgcccaat gcgtgctcag ccaacaactc tcatcactac      300

atcagtatgg gaagctctgg actggagcta actttcacta acgactccat ccttaatcac      360

aatttttgca acttaacctc cgctttcaac aaaaagactt ttgaccatac actcatgagt      420

atagtctcga gtctgcacct cagtattaga gggaattcca accacaaagc agtgtcttgt      480

gattttaaca atggcatcac cattcaatac aacttgtcat tttcggaccc acagagcgct      540

atgagccagt gtaggacttt cagaggtaga gtcttggaca tgtttagaac tgcctttgga      600

ggaaaataca tgagaagtgg ctggggctgg gcaggttcag atggcaagac cacttggtgc      660

agccaaacaa gctatcagta cctaatcata caaaacagga cttgggaaaa ccactgtaga      720

tatgcaggcc cttttgggat gtctagaatc ctctttgctc aggaaaagac aaagtttctc      780

actaggagac ttgcaggcac attcacctgg accctgtcag actcctcagg agtagaaaat      840

ccaggtggtt attgcctgac caaatggatg atccttgctg cagagctcaa atgttttggg      900

aatacagctg ttgcaaaatg taatgtcaat catgatgaag agttctgtga catgctacga      960

ctaattgatt acaacaaggc cgccctgagt aagttcaagc aagatgtaga gtctgccttg     1020

catgtattca aaacaacagt aaattctctg atttccgatc agctgttgat gaggaatcat     1080

ctaagagatc taatgggggt accatactgt aattactcaa agttctggta tctggaacat     1140

gctaagactg gtgagactag tgtacccaag tgctggcttg tcactaatgg ctcctacttg     1200

aatgagaccc actttagtga tcaaatcgaa caagaagcag ataacatgat cacagagatg     1260

ttgaggaagg actacataaa aagacaaggg agtactcctt tagccttaat ggatcttttg     1320

atgttttcaa catcagcata tctaatcagc atctttctgc atcttgtgaa gataccaaca     1380

catagacaca taaagggcgg ttcatgtcca aagccacacc gcttgaccaa caaggggatc     1440

tgtagttgtg gtgcattcaa ggtgcctggt gtaaaaacta tctggaaaag acgctga        1497


<210>  5
<211>  2209
<212>  PRT
<213>  Lymphocytic choriomeningitis virus


<220>
<221>  MISC_FEATURE
<223>  Lymphocytic choriomeningitis virus Mutant L-Protein; ssrna 
       ambisense-strand viruses; arenaviridae; arenavirus; old world 
       arenaviruses

<400>  5

Met Asp Glu Thr Ile Ala Asp Leu Arg Glu Leu Cys Leu Asn Tyr Ile 
1               5                   10                  15      


Glu Gln Asp Glu Arg Leu Ser Arg Gln Lys Leu Asn Phe Leu Gly Gln 
            20                  25                  30          


Arg Glu Pro Arg Met Val Leu Ile Glu Gly Leu Lys Leu Leu Ser Arg 
        35                  40                  45              


Cys Ile Glu Ile Asp Ser Ala Asp Lys Ser Gly Cys Ile His Asn His 
    50                  55                  60                  


Asp Asp Lys Ser Val Glu Thr Ile Leu Ile Asp Ser Gly Ile Val Cys 
65                  70                  75                  80  


Pro Gly Leu Pro Leu Ile Ile Pro Asp Gly Tyr Lys Leu Ile Asp Asn 
                85                  90                  95      


Ser Leu Ile Leu Leu Glu Cys Phe Val Arg Ser Thr Pro Ala Ser Phe 
            100                 105                 110         


Glu Lys Lys Phe Ile Glu Asp Thr Asn Lys Leu Ala Cys Ile Lys Glu 
        115                 120                 125             


Asp Leu Ala Val Ala Gly Ile Thr Leu Val Pro Ile Val Asp Gly Arg 
    130                 135                 140                 


Cys Asp Tyr Asp Asn Ser Phe Met Pro Glu Trp Val Asn Phe Lys Phe 
145                 150                 155                 160 


Arg Asp Leu Leu Phe Lys Leu Leu Glu Tyr Ser Ser Gln Asp Glu Lys 
                165                 170                 175     


Val Phe Glu Glu Ser Glu Tyr Phe Arg Leu Cys Glu Ser Leu Lys Thr 
            180                 185                 190         


Thr Val Asp Lys Arg Ser Gly Met Asp Ser Met Lys Ile Leu Lys Asp 
        195                 200                 205             


Ala Arg Ser Phe His Asn Asp Glu Ile Met Lys Met Cys His Asp Gly 
    210                 215                 220                 


Val Asn Pro Asn Met Ser Cys Asp Asp Val Val Phe Gly Ile Asn Ser 
225                 230                 235                 240 


Phe Phe Gly Arg Phe Arg Arg Asp Leu Leu Asn Gly Lys Leu Lys Arg 
                245                 250                 255     


Asn Phe Gln Lys Val Ser Pro Gly Gly Leu Ile Lys Glu Phe Ser Glu 
            260                 265                 270         


Leu Tyr Glu Thr Leu Thr Asp Asn Asp Asp Ile Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Ala Val Glu Ser Cys Pro Leu Met Arg Phe Ile Thr Ala Glu Thr 
    290                 295                 300                 


His Gly His Glu Arg Gly Ser Asp Ala Asn Thr Glu Tyr Glu Arg Leu 
305                 310                 315                 320 


Leu Ser Met Leu Asn Lys Val Lys Ser Leu Lys Leu Leu Asn Thr Arg 
                325                 330                 335     


Arg Arg Gln Leu Leu Asn Leu Asp Val Leu Cys Leu Ser Ser Leu Ile 
            340                 345                 350         


Lys Gln Ser Ile Ser Lys Gly Leu Glu Asn Asp Lys His Trp Val Gly 
        355                 360                 365             


Cys Cys Tyr Ser Ser Val Asn Asp Arg Leu Val Ser Leu Gln Ser Thr 
    370                 375                 380                 


Lys Glu Glu Phe Met Arg Leu Leu Lys Asn Arg Arg Lys Ser Arg Val 
385                 390                 395                 400 


His Lys Lys Ala Ser Leu Asp Glu Leu Phe Arg Val Ser Ile Asn Glu 
                405                 410                 415     


Phe Ile Ala Lys Ile Gln Lys Cys Leu Ser Thr Val Gly Leu Ser Phe 
            420                 425                 430         


Glu His Tyr Gly Leu Ser Glu Cys Leu Val Gln Glu Cys His Ile Pro 
        435                 440                 445             


Phe Ala Glu Phe Glu Asn Phe Met Arg Ala Gly Thr His Pro Val Met 
    450                 455                 460                 


His Tyr Thr Lys Phe Glu Asp Tyr Thr Phe Gln Pro Asn Ile Glu Gln 
465                 470                 475                 480 


Leu Arg Gly Leu Gln Ser Leu Arg Lys Leu Ser Ser Val Cys Leu Ala 
                485                 490                 495     


Leu Thr Asn Ser Met Lys Thr Ser Ser Val Ala Arg Leu Arg Gln Asn 
            500                 505                 510         


Gln Leu Gly Ser Val Arg Tyr Gln Val Val Glu Cys Lys Glu Val Phe 
        515                 520                 525             


Cys Gln Ile Ile Lys Leu Asp Ser Glu Glu Tyr His Leu Leu Tyr Gln 
    530                 535                 540                 


Lys Thr Gly Glu Ser Ser Arg Cys Tyr Ser Ile Gln Gly Pro Asp Gly 
545                 550                 555                 560 


His Leu Ile Ser Phe Tyr Ala Asp Pro Lys Arg Phe Phe Leu Pro Ile 
                565                 570                 575     


Phe Ser Asp Glu Val Leu His Asn Met Ile Asp Thr Met Ile Ser Trp 
            580                 585                 590         


Ile Arg Ser Cys Pro Asp Leu Lys Asp Ser Leu Ile Asp Ile Glu Thr 
        595                 600                 605             


Ala Leu Arg Thr Leu Ile Leu Leu Met Leu Thr Asn Pro Thr Lys Arg 
    610                 615                 620                 


Asn Gln Lys Gln Val Gln Asn Ile Arg Tyr Leu Val Met Ala Ile Val 
625                 630                 635                 640 


Ser Asp Phe Ser Ser Thr Ser Leu Met Asp Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Ile Thr Pro Ala Glu Lys Val Val Tyr Arg Leu Leu Arg Phe Leu Ile 
            660                 665                 670         


Arg Thr Ile Phe Gly Thr Gly Glu Lys Val Leu Leu Ser Ala Lys Phe 
        675                 680                 685             


Lys Phe Met Leu Asn Val Ser Tyr Leu Cys His Leu Ile Thr Lys Glu 
    690                 695                 700                 


Thr Pro Asp Arg Leu Thr Asp Gln Ile Lys Cys Phe Glu Lys Phe Phe 
705                 710                 715                 720 


Glu Pro Lys Ser Glu Phe Gly Phe Phe Val Asn Pro Lys Glu Thr Ile 
                725                 730                 735     


Thr Pro Glu Glu Glu Cys Val Phe Tyr Glu Gln Met Lys Lys Phe Thr 
            740                 745                 750         


Gly Lys Asp Ile Asp Cys Gln His Ser Thr Pro Gly Val Asn Leu Glu 
        755                 760                 765             


Ile Phe Ser Met Met Val Ser Ser Phe Asn Asn Gly Thr Leu Ile Leu 
    770                 775                 780                 


Lys Gly Glu Lys Arg Leu Asn Asn Leu Asp Pro Met Thr Asn Ser Gly 
785                 790                 795                 800 


Cys Ala Thr Ala Leu Asp Leu Ala Ser Asn Lys Ser Val Val Val Asn 
                805                 810                 815     


Lys His Leu Asn Gly Glu Arg Leu Leu Glu Tyr Asp Phe Asn Lys Leu 
            820                 825                 830         


Leu Val Ser Ala Val Ser Gln Ile Thr Glu Gly Phe Met Arg Lys Gln 
        835                 840                 845             


Lys Tyr Lys Leu Arg His Ser Asp Tyr Glu Tyr Lys Val Ser Lys Leu 
    850                 855                 860                 


Val Ser Arg Leu Val Ile Gly Ser Arg Lys Thr Glu Val Asp Lys Leu 
865                 870                 875                 880 


Glu Asp Asp Pro Val Asp Val Cys Phe Glu Gly Glu Glu Glu Thr Ser 
                885                 890                 895     


Phe Phe Arg Ser Leu Glu Asp Lys Val Ser Ser Thr Ile Thr Arg Tyr 
            900                 905                 910         


Asn Arg Gly Thr Arg Leu Asn Glu Gly Gln Gly Glu Gly Glu Phe Lys 
        915                 920                 925             


Asn Thr Lys Gly Leu His His Leu Gln Ile Ile Leu Ser Gly Lys Arg 
    930                 935                 940                 


Ala Tyr Leu Arg Lys Val Ile Leu Ser Glu Ile Ser Phe His Leu Val 
945                 950                 955                 960 


Glu Asp Phe Asp Pro Ser Cys Leu Thr Asn Asp Asp Met Arg Phe Ile 
                965                 970                 975     


Cys Glu Ala Val Glu Gly Ser Thr Glu Leu Ser Pro Leu Tyr Phe Thr 
            980                 985                 990         


Ser Ala Val Lys Glu Gln Cys Gly  Leu Asp Glu Met Ala  Arg Asn Leu 
        995                 1000                 1005             


Cys Arg  Lys Phe Phe Ser Glu  Gly Asp Trp Phe Ser  Cys Met Lys 
    1010                 1015                 1020             


Met Ile  Leu Leu Gln Met Asn  Ala Asn Ala Tyr Ser  Gly Lys Tyr 
    1025                 1030                 1035             


Arg His  Met Gln Arg Gln Ser  Leu Asn Phe Lys Phe  Asp Trp Asp 
    1040                 1045                 1050             


Lys Leu  Glu Glu Asp Val Arg  Ile Ser Glu Arg Glu  Ser Asn Ser 
    1055                 1060                 1065             


Glu Ser  Leu Ser Lys Ala Leu  Ser Leu Thr Lys Cys  Met Ser Ala 
    1070                 1075                 1080             


Ala Leu  Lys Asn Leu Cys Phe  Tyr Ser Glu Glu Ser  Pro Thr Ser 
    1085                 1090                 1095             


Tyr Thr  Ser Val Gly Pro Asp  Ser Gly Arg Leu Lys  Phe Ala Leu 
    1100                 1105                 1110             


Ser Tyr  Lys Glu Gln Val Gly  Gly Asn Arg Glu Leu  Tyr Ile Gly 
    1115                 1120                 1125             


Asp Leu  Arg Thr Lys Met Phe  Thr Arg Leu Val Glu  Asp Tyr Phe 
    1130                 1135                 1140             


Glu Ser  Phe Ser Ser Phe Phe  Ser Gly Ser Cys Leu  Asn Asn Asp 
    1145                 1150                 1155             


Lys Glu  Phe Glu Asn Ala Ile  Leu Ser Met Thr Ile  Asn Val Arg 
    1160                 1165                 1170             


Glu Gly  Leu Leu Asn Tyr Ser  Met Asp His Ser Lys  Trp Gly Pro 
    1175                 1180                 1185             


Met Met  Cys Pro Phe Leu Phe  Leu Met Leu Leu Gln  Asn Leu Lys 
    1190                 1195                 1200             


Leu Gly  Asp Asp Gln Tyr Val  Arg Ser Gly Lys Asp  His Val Ser 
    1205                 1210                 1215             


Thr Leu  Leu Thr Trp His Met  His Lys Leu Val Glu  Val Pro Phe 
    1220                 1225                 1230             


Pro Val  Val Asn Ala Met Met  Lys Ser Tyr Val Lys  Ser Lys Leu 
    1235                 1240                 1245             


Lys Leu  Leu Lys Gly Ser Gly  Thr Thr Val Thr Glu  Arg Ile Phe 
    1250                 1255                 1260             


Arg Glu  Tyr Phe Glu Met Gly  Val Val Pro Ser His  Ile Ser Ser 
    1265                 1270                 1275             


Leu Ile  Asp Met Gly Gln Gly  Ile Leu His Asn Ala  Ser Asp Phe 
    1280                 1285                 1290             


Tyr Gly  Leu Ile Ser Glu Arg  Phe Ile Asn Tyr Cys  Ile Gly Val 
    1295                 1300                 1305             


Ile Phe  Gly Glu Arg Pro Glu  Ala Tyr Thr Ser Ser  Asp Asp Gln 
    1310                 1315                 1320             


Ile Thr  Leu Phe Asp Lys Arg  Leu Ser Asp Leu Val  Asp Ser Asp 
    1325                 1330                 1335             


Pro Glu  Glu Val Leu Val Leu  Leu Glu Phe His Ser  His Leu Ser 
    1340                 1345                 1350             


Gly Leu  Leu Asn Lys Phe Ile  Ser Pro Lys Ser Val  Val Gly Arg 
    1355                 1360                 1365             


Phe Ala  Ala Glu Phe Lys Ser  Arg Phe Tyr Val Trp  Gly Glu Glu 
    1370                 1375                 1380             


Val Pro  Leu Leu Thr Lys Phe  Val Ser Ala Ala Leu  His Asn Val 
    1385                 1390                 1395             


Lys Cys  Lys Glu Pro His Gln  Leu Cys Glu Thr Ile  Asp Thr Ile 
    1400                 1405                 1410             


Ala Asp  Gln Ala Ile Ala Asn  Gly Val Pro Val Phe  Leu Val Asn 
    1415                 1420                 1425             


Cys Ile  Gln Arg Arg Thr Leu  Asp Leu Leu Lys Tyr  Ala Asn Phe 
    1430                 1435                 1440             


Pro Leu  Asp Pro Phe Leu Leu  Asn Thr His Thr Asp  Val Lys Asp 
    1445                 1450                 1455             


Trp Leu  Asp Gly Ser Arg Gly  Tyr Arg Ile Gln Arg  Leu Ile Glu 
    1460                 1465                 1470             


Glu Leu  Cys Pro Ser Glu Thr  Lys Ile Met Arg Lys  Leu Val Arg 
    1475                 1480                 1485             


Arg Leu  His His Lys Leu Lys  Asn Gly Glu Cys Asn  Glu Glu Phe 
    1490                 1495                 1500             


Phe Leu  Asp Leu Phe Asn Arg  Glu Lys Glu Glu Ala  Ile Leu Gln 
    1505                 1510                 1515             


Leu Gly  Glu Ile Leu Gly Leu  Glu Asp Asp Leu Asn  Glu Leu Ala 
    1520                 1525                 1530             


Ser Ile  Asn Trp Leu Asn Leu  Asn Glu Met Phe Pro  Leu Arg Met 
    1535                 1540                 1545             


Val Leu  Arg Gln Lys Val Val  Tyr Pro Ser Val Met  Thr Phe Gln 
    1550                 1555                 1560             


Glu Glu  Lys Ile Pro Ser Leu  Ile Lys Thr Leu Gln  Asn Lys Leu 
    1565                 1570                 1575             


Cys Ser  Lys Phe Thr Arg Gly  Ala Gln Lys Leu Leu  Ser Glu Ala 
    1580                 1585                 1590             


Ile Asn  Lys Ser Ala Phe Gln  Ser Cys Val Ser Ser  Gly Phe Ile 
    1595                 1600                 1605             


Gly Leu  Cys Lys Thr Leu Gly  Ser Arg Cys Val Arg  Asn Lys Asn 
    1610                 1615                 1620             


Arg Glu  Asn Met Tyr Ile Arg  Lys Val Leu Glu Asp  Leu Thr Met 
    1625                 1630                 1635             


Asp Glu  His Val Thr Arg Val  His Lys Gln Asp Gly  Val Met Leu 
    1640                 1645                 1650             


Tyr Ile  Cys Asp Lys Gln Arg  His Pro Glu Ala His  Arg Asp His 
    1655                 1660                 1665             


Ile Asn  Leu Leu Arg Pro Leu  Leu Trp Asp Tyr Ile  Cys Ile Ser 
    1670                 1675                 1680             


Leu Ser  Asn Ser Phe Glu Leu  Gly Val Trp Val Leu  Ala Glu Pro 
    1685                 1690                 1695             


Val Lys  Gly Lys Asn Glu Ser  Asn Ser Ala Val Arg  His Leu Asn 
    1700                 1705                 1710             


Pro Cys  Asp Tyr Val Ala Arg  Lys Pro Glu Ser Ser  Arg Leu Leu 
    1715                 1720                 1725             


Glu Asp  Lys Val Ser Leu Asn  His Val Ile Gln Ser  Val Arg Arg 
    1730                 1735                 1740             


Leu Tyr  Pro Lys Ile Phe Glu  Asp Gln Leu Leu Pro  Phe Met Ser 
    1745                 1750                 1755             


Asp Val  Ser Ser Lys Asn Met  Arg Trp Ser Pro Arg  Ile Lys Phe 
    1760                 1765                 1770             


Leu Asp  Leu Cys Val Leu Ile  Asp Ile Asn Ser Glu  Ser Leu Ser 
    1775                 1780                 1785             


Leu Ile  Ser His Val Val Lys  Trp Lys Arg Asp Glu  His Tyr Thr 
    1790                 1795                 1800             


Val Leu  Phe Ser Asp Leu Val  Asn Ser His Gln Arg  Ser Asp Ser 
    1805                 1810                 1815             


Ser Leu  Val Asp Glu Phe Val  Val Ser Thr Arg Asp  Val Cys Lys 
    1820                 1825                 1830             


Asn Phe  Leu Lys Gln Val Tyr  Phe Glu Ser Phe Val  Arg Glu Phe 
    1835                 1840                 1845             


Val Ala  Thr Ala Arg Thr Leu  Gly Asn Phe Ser Trp  Phe Pro His 
    1850                 1855                 1860             


Lys Asp  Met Met Pro Ser Glu  Asp Gly Ala Glu Ala  Leu Gly Pro 
    1865                 1870                 1875             


Phe Gln  Ser Phe Ile Leu Lys  Val Val Asn Lys Lys  Ile Glu Arg 
    1880                 1885                 1890             


Pro Met  Phe Arg Asn Asp Leu  Gln Phe Gly Phe Gly  Trp Phe Ser 
    1895                 1900                 1905             


Tyr Arg  Val Gly Asp Val Val  Cys Asn Ala Ala Met  Leu Ile Lys 
    1910                 1915                 1920             


Gln Gly  Leu Thr Asp Pro Lys  Ala Phe Lys Ser Leu  Arg Asp Leu 
    1925                 1930                 1935             


Trp Asp  Tyr Met Leu Ser Ser  Thr Glu Gly Ile Leu  Glu Phe Ser 
    1940                 1945                 1950             


Ile Thr  Val Asp Phe Thr His  Asn Gln Asn Asn Thr  Asp Cys Leu 
    1955                 1960                 1965             


Arg Lys  Phe Ser Leu Ile Phe  Val Val Lys Cys Gln  Leu Gln Ser 
    1970                 1975                 1980             


Pro Gly  Val Ala Asp Tyr Leu  Ser Cys Ser His Ser  Phe Lys Gly 
    1985                 1990                 1995             


Glu Val  Asp Arg Arg Leu Leu  Asp Glu Cys Leu Asn  Leu Leu Arg 
    2000                 2005                 2010             


Thr Asp  Pro Ile Phe Lys Ala  Asn Asp Gly Val Phe  Asp Ile Arg 
    2015                 2020                 2025             


Ser Glu  Glu Phe Glu Asp Tyr  Met Glu Asp Pro Leu  Thr Leu Gly 
    2030                 2035                 2040             


Asp Ser  Leu Glu Leu Glu Leu  Ile Gly Ser Arg Arg  Ile Leu Asn 
    2045                 2050                 2055             


Glu Ile  Lys Ser Thr Asp Phe  Glu Arg Ile Gly Pro  Glu Trp Glu 
    2060                 2065                 2070             


Pro Val  Pro Leu Thr Ile Arg  Lys Gly Ala Leu Phe  Glu Gly Arg 
    2075                 2080                 2085             


Asn Phe  Val Gln Asn Ile Ser  Val Lys Leu Glu Thr  Lys Asp Met 
    2090                 2095                 2100             


Arg Val  Phe Leu Ala Glu Leu  Glu Gly Cys Gly Lys  Ile Gly Asp 
    2105                 2110                 2115             


Val Leu  Gly Ser Leu Leu Leu  His Arg Phe Arg Thr  Gly Glu His 
    2120                 2125                 2130             


Leu Met  Glu Ser Glu Ile Ser  Thr Val Leu Gln Glu  Leu Cys Met 
    2135                 2140                 2145             


Asp Arg  Ser Val Met Leu Thr  Pro Leu Ser Phe Val  Pro Asp Trp 
    2150                 2155                 2160             


Phe Thr  Phe Arg Asp Cys Arg  Leu Cys Phe Ser Lys  Ser Lys Asn 
    2165                 2170                 2175             


Thr Val  Met Tyr Glu Thr Thr  Gly Gly Arg Phe Arg  Leu Lys Gly 
    2180                 2185                 2190             


Lys Ser  Cys Asp Asp Trp Leu  Ala Glu Arg Val Ala  Glu Glu Ile 
    2195                 2200                 2205             


Asp 
    


<210>  6
<211>  6630
<212>  DNA
<213>  Lymphocytic choriomeningitis virus


<220>
<221>  MISC_FEATURE
<223>  Lymphocytic choriomeningitis virus Mutant L-Protein; ssrna 
       ambisense-strand viruses; arenaviridae; arenavirus; old world 
       arenaviruses

<400>  6
atggatgaaa ctattgcaga tttgagagag ttgtgtctaa attacataga acaggacgag       60

aggctgtcaa ggcaaaaact caacttcctg ggacaaagag aacccagaat ggtgctaatt      120

gagggactca aattgttatc acgctgtata gagatagaca gtgcagacaa aagtggttgc      180

atacacaacc acgatgacaa atctgttgaa acaatcctaa tagactctgg gattgtgtgt      240

ccaggactgc cactcatcat ccctgatggt tataagttga ttgacaattc ccttattctt      300

cttgaatgtt ttgttagaag cacaccagct agttttgaaa agaagttcat tgaggacacc      360

aacaaactag catgcatcaa agaagatctt gctgttgcag gcatcacact ggttccaata      420

gtggatggtc gttgtgatta tgataacagt ttcatgccag aatgggtgaa ttttaagttc      480

agagacctcc tatttaaact cctggagtat tctagtcaag atgagaaagt ttttgaggag      540

tctgaatact tcaggctctg tgagtctctt aagaccactg ttgacaaacg ttccggcatg      600

gactcaatga aaattttgaa agacgcaaga tcatttcata acgatgagat tatgaaaatg      660

tgccacgatg gtgtcaaccc caacatgagt tgcgatgatg tggtctttgg cataaattcc      720

ttttttggca ggtttaggag ggacctgtta aatgggaaac tcaaaaggaa tttccaaaag      780

gtcagccctg ggggcttaat caaggaattc tctgaacttt atgaaaccct tactgataat      840

gatgacatat taatgttgag caaagaggca gttgaatcct gccccttaat gaggttcatt      900

acagcagaga cccatgggca tgagagagga agcgatgcta acactgagta tgaaaggcta      960

ctctctatgt tgaacaaggt gaaaagttta aaattattaa acactagaag gagacagctg     1020

ctgaacttag atgtcttatg tctttcttca cttattaagc agtcaatttc caaagggttg     1080

gaaaatgata aacattgggt tggttgctgc tacagtagtg tgaatgatag gcttgtgagc     1140

cttcaaagta ccaaagaaga attcatgaga cttttgaaga acagaagaaa atcaagagtg     1200

cacaaaaagg catctcttga tgagcttttt agggtatcca taaatgagtt catagcaaaa     1260

atccagaaat gcctatcaac agtgggactt agttttgagc attacggact atcagaatgc     1320

ctcgtgcaag aatgccatat accatttgct gaatttgaga actttatgag agccgggact     1380

catcctgtaa tgcattacac aaaatttgaa gattacactt tccagcctaa catagagcaa     1440

ttgaggggtt tacagagttt gagaaaactg tcatctgttt gtttggctct aacaaacagc     1500

atgaaaacaa gctcagttgc aaggttgaga cagaaccaac tggggtctgt gagatatcaa     1560

gtggtggagt gcaaagaggt gttttgccag ataataaaac tggattccga agagtatcat     1620

ctactatatc agaaaactgg agaatcatcg aggtgttatt ccatacaagg tccggatggt     1680

cacttgattt ccttttacgc agatccaaaa aggttctttt taccaatttt ttcagatgag     1740

gtgttgcaca acatgataga cacaatgatt tcatggatta ggtcatgccc tgacttaaaa     1800

gattctctta ttgacattga gactgcacta aggacattga tcctactgat gctcaccaac     1860

ccaacaaaga gaaatcaaaa gcaggttcaa aatattaggt atttagtgat ggccatcgtc     1920

tcagactttt catcgacctc attaatggat aagttgaagg aggatctaat cacacctgcc     1980

gagaaagtgg tgtacaggct gcttcggttt ttgattagga caatttttgg tactggtgaa     2040

aaggtgttat tgagtgcaaa attcaagttt atgttgaatg tgtcatacct gtgtcatttg     2100

atcacaaagg agacccctga tagattgaca gatcagataa aatgttttga aaagttcttt     2160

gagcccaaga gtgagtttgg tttctttgtc aaccctaagg aaacaatcac acccgaagag     2220

gaatgtgttt tttatgaaca aatgaagaag ttcaccggta aagatattga ttgtcagcat     2280

tcaacccctg gtgttaattt agagatcttt agcatgatgg tatcttcatt caacaatggc     2340

accttaattc taaaagggga gaaaaggctc aacaatctgg accccatgac caactctgga     2400

tgtgcgacag cattagatct cgcaagcaac aaaagtgtgg ttgtcaataa acatctgaat     2460

ggagaacggc ttttggagta tgattttaac aaattgcttg ttagtgctgt gagccaaatt     2520

acagagggct tcatgaggaa acaaaagtat aagctgagac actcagatta cgaatataag     2580

gtctcaaagc ttgtctctag attagtcatc ggttccagga aaacagaagt agacaaattg     2640

gaagatgatc cggtagatgt gtgtttcgag ggggaggagg agacaagttt tttcaggagt     2700

ttagaagata aggtcagctc cacaataaca cggtataata gaggcactag gcttaatgaa     2760

gggcaagggg agggagaatt caagaacaca aaaggactac accaccttca gattattttg     2820

tcaggtaaaa gagcttatct gaggaaagtc attttatcag aaatttcatt tcatctagta     2880

gaggactttg atccatcctg tctcaccaat gacgacatga ggtttatttg tgaggctgtt     2940

gaaggttcaa cagaactgtc accattgtat tttacatcag ctgtcaaaga acaatgtggt     3000

ctggatgaga tggcaagaaa cctctgtaga aagttcttct cagagggtga ttggttctca     3060

tgtatgaaga tgatcttgtt acagatgaat gcaaatgcgt attcagggaa gtacagacac     3120

atgcagaggc agagcttaaa ttttaaattt gactgggaca aattggaaga agatgtaaga     3180

attagtgaaa gggaaagcaa ttctgaatct ctaagtaagg ccctttcatt gacaaaatgc     3240

atgagtgctg ctctaaagaa tctgtgtttt tactcagaag aatcaccaac atcatacact     3300

tcagttggcc ctgactctgg gagactaaaa tttgcattgt catacaaaga gcaggttggg     3360

ggaaatagag agctttacat tggggatttg aggacaaaaa tgttcacaag attggtagaa     3420

gattattttg aatccttttc tagtttcttt tcaggatctt gtttaaacaa tgataaagag     3480

tttgaaaatg caatcttgtc aatgactatc aatgtgagag aagggttgtt aaactacagc     3540

atggatcaca gcaaatgggg accaatgatg tgcccattcc tattcttaat gcttctccaa     3600

aatctcaaac tgggtgatga tcagtacgtg cgttctggaa aagatcatgt tagcaccttg     3660

ttgacttggc atatgcataa acttgttgaa gtccctttcc ctgttgtgaa tgcaatgatg     3720

aaatcatatg ttaaatcaaa actcaagctt ctcaaagggt caggaacgac tgttacggag     3780

agaatcttta gagagtattt tgaaatgggg gtggtgccat ctcacatatc tagtctcatt     3840

gacatgggac aggggatcct acacaatgct tctgattttt acggtttaat tagtgaaagg     3900

tttatcaatt attgtattgg tgtcattttt ggagagaggc cagaagccta tacatcaagt     3960

gatgatcaga tcactttatt tgacaagaga ttgagtgact tagttgatag tgacccagaa     4020

gaagtccttg tcttgctgga attccactct cacttaagtg gtttgttgaa caagttcatc     4080

agtccaaaaa gtgtggttgg gcggtttgca gcggaattca aatccagatt ttatgtgtgg     4140

ggggaggagg tccctctcct cacgaaattt gtgtctgcgg cactacacaa tgttaagtgt     4200

aaagaaccgc atcaactttg tgagacaata gatacgattg ctgatcaagc tatagcaaat     4260

ggagttccag tttttttagt aaactgtatc cagaggagga cactggatct cttgaaatat     4320

gctaatttcc ctttagatcc attcttgtta aacactcaca ctgatgtaaa ggattggtta     4380

gatggttcta gaggttatag aatccaaaga ctcattgaag aattgtgtcc cagtgaaaca     4440

aagatcatga gaaaacttgt aagaagacta catcacaaac tcaagaacgg tgaatgtaac     4500

gaggaatttt ttctagacct cttcaacagg gaaaaggaag aggccatcct tcaattggga     4560

gagattcttg gtcttgagga tgatcttaat gagttggcaa gcatcaattg gttgaatctg     4620

aatgaaatgt tcccattgag gatggttctg agacaaaaag tggtttaccc atcagtaatg     4680

acctttcaag aggaaaagat cccctcattg attaaaacac tccaaaataa gctttgtagt     4740

aagttcacaa gaggtgcaca gaagctgttg tcagaggcaa tcaacaaatc agcttttcag     4800

agttgtgtct catccggctt tataggtctc tgtaagactt taggaagtag gtgtgtgaga     4860

aataaaaaca gggaaaatat gtatatcaga aaggtgcttg aagatctgac catggatgaa     4920

catgtcacaa gggttcacaa acaagatggt gtgatgttgt acatttgcga caagcagaga     4980

cacccagagg ctcaccgtga ccacatcaac cttttgaggc cccttctctg ggactacatt     5040

tgcatctcat tgagcaactc ttttgagctg ggtgtttggg ttttagcaga acctgtgaaa     5100

ggaaagaacg agagtaattc ggctgttagg cacttaaatc catgtgatta tgtagcaaga     5160

aaacctgaga gttcgagact actagaggat aaagtgagtt tgaatcatgt aattcaatct     5220

gtgaggcgac tgtaccccaa aatctttgag gatcagttgc tcccattcat gtctgatgtg     5280

agctcaaaaa atatgagatg gagtcccagg attaaattcc ttgacctttg tgtgctgatt     5340

gacatcaact cagagtcttt gtcactcatt tctcatgttg tcaaatggaa gagggacgaa     5400

cattacactg tgctgttttc tgatctcgtc aactctcacc aacggtcaga ctcaagttta     5460

gttgatgaat ttgttgtcag cacaagggat gtctgcaaga actttttgaa gcaagtgtat     5520

ttcgaatcat ttgtacgaga gtttgttgca acagctagga ccttaggtaa cttttcatgg     5580

ttcccccata aggacatgat gccatctgaa gatggcgctg aagcactggg acccttccaa     5640

tcatttattt tgaaagtggt gaacaagaaa atagagaggc ccatgtttag gaatgacttg     5700

cagtttggtt ttggttggtt ctcttatcgt gtgggggatg ttgtgtgtaa tgccgctatg     5760

ttaattaagc agggtttgac agatccaaaa gcatttaaat ctttaagaga tttgtgggat     5820

tacatgctca gcagcacaga ggggatattg gagttctcaa tcacagtgga tttcacacac     5880

aaccagaaca acactgactg cttgaggaaa ttttcattga tctttgtggt taaatgccaa     5940

ttacagagtc caggtgtagc tgattactta tcgtgctctc attccttcaa aggtgaggtt     6000

gacaggagat tattagatga gtgtctcaat ctgttgagga cagaccccat ctttaaagcg     6060

aatgatggag tctttgacat taggtctgaa gagtttgaag attacatgga agaccctttg     6120

acacttggtg attcactaga acttgaacta ataggttcta gaaggattct gaatgagatc     6180

aaatctactg actttgagag gatagggcct gagtgggaac ctgtgcctct gaccataagg     6240

aagggtgccc tctttgaggg gaggaacttt gttcagaata tctctgtgaa attggagaca     6300

aaggacatga gggtctttct ggcagagctc gagggctgtg gaaaaattgg tgatgtcctc     6360

ggcagcctcc tcctgcaccg attcagaact ggtgagcact tgatggagtc agaaataagt     6420

acagttcttc aggagctctg catggacaga tccgtcatgc tgacaccatt atcttttgtg     6480

ccagattggt tcaccttcag agattgtagg ctctgcttca gcaagtcaaa gaacactgta     6540

atgtatgaga caactggggg caggttcaga ctcaagggga aatcctgtga cgattggctg     6600

gcggagcggg tggccgagga gatcgactag                                      6630


<210>  7
<211>  2209
<212>  PRT
<213>  Lymphocytic choriomeningitis virus


<220>
<221>  MISC_FEATURE
<223>  Lymphocytic choriomeningitis virus Wildtype L-Protein; ssrna 
       ambisense-strand viruses; arenaviridae; arenavirus; old world 
       arenaviruses

<400>  7

Met Asp Glu Thr Ile Ala Asp Leu Arg Glu Leu Cys Leu Asn Tyr Ile 
1               5                   10                  15      


Glu Gln Asp Glu Arg Leu Ser Arg Gln Lys Leu Asn Phe Leu Gly Gln 
            20                  25                  30          


Arg Glu Pro Arg Met Val Leu Ile Glu Gly Leu Lys Leu Leu Ser Arg 
        35                  40                  45              


Cys Ile Glu Ile Asp Ser Ala Asp Lys Ser Gly Cys Ile His Asn His 
    50                  55                  60                  


Asp Asp Lys Ser Val Glu Thr Ile Leu Ile Asp Ser Gly Ile Val Cys 
65                  70                  75                  80  


Pro Gly Leu Pro Leu Ile Ile Pro Asp Gly Tyr Lys Leu Ile Asp Asn 
                85                  90                  95      


Ser Leu Ile Leu Leu Glu Cys Phe Val Arg Ser Thr Pro Ala Ser Phe 
            100                 105                 110         


Glu Lys Lys Phe Ile Glu Asp Thr Asn Lys Leu Ala Cys Ile Lys Glu 
        115                 120                 125             


Asp Leu Ala Val Ala Gly Ile Thr Leu Val Pro Ile Val Asp Gly Arg 
    130                 135                 140                 


Cys Asp Tyr Asp Asn Ser Phe Met Pro Glu Trp Val Asn Phe Lys Phe 
145                 150                 155                 160 


Arg Asp Leu Leu Phe Lys Leu Leu Glu Tyr Ser Ser Gln Asp Glu Lys 
                165                 170                 175     


Val Phe Glu Glu Ser Glu Tyr Phe Arg Leu Cys Glu Ser Leu Lys Thr 
            180                 185                 190         


Thr Val Asp Lys Arg Ser Gly Met Asp Ser Met Lys Ile Leu Lys Asp 
        195                 200                 205             


Ala Arg Ser Phe His Asn Asp Glu Ile Met Lys Met Cys His Asp Gly 
    210                 215                 220                 


Val Asn Pro Asn Met Ser Cys Asp Asp Val Val Phe Gly Ile Asn Ser 
225                 230                 235                 240 


Phe Phe Gly Arg Phe Arg Arg Asp Leu Leu Asn Gly Lys Leu Lys Arg 
                245                 250                 255     


Asn Phe Gln Lys Val Ser Pro Gly Gly Leu Ile Lys Glu Phe Ser Glu 
            260                 265                 270         


Leu Tyr Glu Thr Leu Thr Asp Asn Asp Asp Ile Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Ala Val Glu Ser Cys Pro Leu Met Arg Phe Ile Thr Ala Glu Thr 
    290                 295                 300                 


His Gly His Glu Arg Gly Ser Asp Ala Asn Thr Glu Tyr Glu Arg Leu 
305                 310                 315                 320 


Leu Ser Met Leu Asn Lys Val Lys Ser Leu Lys Leu Leu Asn Thr Arg 
                325                 330                 335     


Arg Arg Gln Leu Leu Asn Leu Asp Val Leu Cys Leu Ser Ser Leu Ile 
            340                 345                 350         


Lys Gln Ser Ile Ser Lys Gly Leu Glu Asn Asp Lys His Trp Val Gly 
        355                 360                 365             


Cys Cys Tyr Ser Ser Val Asn Asp Arg Leu Val Ser Leu Gln Ser Thr 
    370                 375                 380                 


Lys Glu Glu Phe Met Arg Leu Leu Lys Asn Arg Arg Lys Ser Arg Val 
385                 390                 395                 400 


His Lys Lys Ala Ser Leu Asp Glu Leu Phe Arg Val Ser Ile Asn Glu 
                405                 410                 415     


Phe Ile Ala Lys Ile Gln Lys Cys Leu Ser Thr Val Gly Leu Ser Phe 
            420                 425                 430         


Glu His Tyr Gly Leu Ser Glu Cys Leu Val Gln Glu Cys His Ile Pro 
        435                 440                 445             


Phe Ala Glu Phe Glu Asn Phe Met Arg Ala Gly Thr His Pro Val Met 
    450                 455                 460                 


His Tyr Thr Lys Phe Glu Asp Tyr Thr Phe Gln Pro Asn Ile Glu Gln 
465                 470                 475                 480 


Leu Arg Gly Leu Gln Ser Leu Arg Lys Leu Ser Ser Val Cys Leu Ala 
                485                 490                 495     


Leu Thr Asn Ser Met Lys Thr Ser Ser Val Ala Arg Leu Arg Gln Asn 
            500                 505                 510         


Gln Leu Gly Ser Val Arg Tyr Gln Val Val Glu Cys Lys Glu Val Phe 
        515                 520                 525             


Cys Gln Ile Ile Lys Leu Asp Ser Glu Glu Tyr His Leu Leu Tyr Gln 
    530                 535                 540                 


Lys Thr Gly Glu Ser Ser Arg Cys Tyr Ser Ile Gln Gly Pro Asp Gly 
545                 550                 555                 560 


His Leu Ile Ser Phe Tyr Ala Asp Pro Lys Arg Phe Phe Leu Pro Ile 
                565                 570                 575     


Phe Ser Asp Glu Val Leu His Asn Met Ile Asp Thr Met Ile Ser Trp 
            580                 585                 590         


Ile Arg Ser Cys Pro Asp Leu Lys Asp Ser Leu Ile Asp Ile Glu Thr 
        595                 600                 605             


Ala Leu Arg Thr Leu Ile Leu Leu Met Leu Thr Asn Pro Thr Lys Arg 
    610                 615                 620                 


Asn Gln Lys Gln Val Gln Asn Ile Arg Tyr Leu Val Met Ala Ile Val 
625                 630                 635                 640 


Ser Asp Phe Ser Ser Thr Ser Leu Met Asp Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Ile Thr Pro Ala Glu Lys Val Val Tyr Arg Leu Leu Arg Phe Leu Ile 
            660                 665                 670         


Arg Thr Ile Phe Gly Thr Gly Glu Lys Val Leu Leu Ser Ala Lys Phe 
        675                 680                 685             


Lys Phe Met Leu Asn Val Ser Tyr Leu Cys His Leu Ile Thr Lys Glu 
    690                 695                 700                 


Thr Pro Asp Arg Leu Thr Asp Gln Ile Lys Cys Phe Glu Lys Phe Phe 
705                 710                 715                 720 


Glu Pro Lys Ser Glu Phe Gly Phe Phe Val Asn Pro Lys Glu Thr Ile 
                725                 730                 735     


Thr Pro Glu Glu Glu Cys Val Phe Tyr Glu Gln Met Lys Lys Phe Thr 
            740                 745                 750         


Gly Lys Asp Ile Asp Cys Gln His Ser Thr Pro Gly Val Asn Leu Glu 
        755                 760                 765             


Ile Phe Ser Met Met Val Ser Ser Phe Asn Asn Gly Thr Leu Ile Leu 
    770                 775                 780                 


Lys Gly Glu Lys Arg Leu Asn Asn Leu Asp Pro Met Thr Asn Ser Gly 
785                 790                 795                 800 


Cys Ala Thr Ala Leu Asp Leu Ala Ser Asn Lys Ser Val Val Val Asn 
                805                 810                 815     


Lys His Leu Asn Gly Glu Arg Leu Leu Glu Tyr Asp Phe Asn Lys Leu 
            820                 825                 830         


Leu Val Ser Ala Val Ser Gln Ile Thr Glu Gly Phe Met Arg Lys Gln 
        835                 840                 845             


Lys Tyr Lys Leu Arg His Ser Asp Tyr Glu Tyr Lys Val Ser Lys Leu 
    850                 855                 860                 


Val Ser Arg Leu Val Ile Gly Ser Arg Lys Thr Glu Val Asp Lys Leu 
865                 870                 875                 880 


Glu Asp Asp Pro Val Asp Val Cys Phe Glu Gly Glu Glu Glu Thr Ser 
                885                 890                 895     


Phe Phe Arg Ser Leu Glu Asp Lys Val Ser Ser Thr Ile Thr Arg Tyr 
            900                 905                 910         


Asn Arg Gly Thr Arg Leu Asn Glu Gly Gln Gly Glu Gly Glu Phe Lys 
        915                 920                 925             


Asn Thr Lys Gly Leu His His Leu Gln Ile Ile Leu Ser Gly Lys Arg 
    930                 935                 940                 


Ala Tyr Leu Arg Lys Val Ile Leu Ser Glu Ile Ser Phe His Leu Val 
945                 950                 955                 960 


Glu Asp Phe Asp Pro Ser Cys Leu Thr Asn Asp Asp Met Arg Phe Ile 
                965                 970                 975     


Cys Glu Ala Val Glu Gly Ser Thr Glu Leu Ser Pro Leu Tyr Phe Thr 
            980                 985                 990         


Ser Ala Val Lys Glu Gln Cys Gly  Leu Asp Glu Met Ala  Arg Asn Leu 
        995                 1000                 1005             


Cys Arg  Lys Phe Phe Ser Glu  Gly Asp Trp Phe Ser  Cys Met Lys 
    1010                 1015                 1020             


Met Ile  Leu Leu Gln Met Asn  Ala Asn Ala Tyr Ser  Gly Lys Tyr 
    1025                 1030                 1035             


Arg His  Met Gln Arg Gln Ser  Leu Asn Phe Lys Phe  Asp Trp Asp 
    1040                 1045                 1050             


Lys Leu  Glu Glu Asp Val Arg  Ile Ser Glu Arg Glu  Ser Asn Ser 
    1055                 1060                 1065             


Glu Ser  Leu Ser Lys Ala Leu  Ser Leu Thr Lys Cys  Met Ser Ala 
    1070                 1075                 1080             


Ala Leu  Lys Asn Leu Cys Phe  Tyr Ser Glu Glu Ser  Pro Thr Ser 
    1085                 1090                 1095             


Tyr Thr  Ser Val Gly Pro Asp  Ser Gly Arg Leu Lys  Phe Ala Leu 
    1100                 1105                 1110             


Ser Tyr  Lys Glu Gln Val Gly  Gly Asn Arg Glu Leu  Tyr Ile Gly 
    1115                 1120                 1125             


Asp Leu  Arg Thr Lys Met Phe  Thr Arg Leu Val Glu  Asp Tyr Phe 
    1130                 1135                 1140             


Glu Ser  Phe Ser Ser Phe Phe  Ser Gly Ser Cys Leu  Asn Asn Asp 
    1145                 1150                 1155             


Lys Glu  Phe Glu Asn Ala Ile  Leu Ser Met Thr Ile  Asn Val Arg 
    1160                 1165                 1170             


Glu Gly  Leu Leu Asn Tyr Ser  Met Asp His Ser Lys  Trp Gly Pro 
    1175                 1180                 1185             


Met Met  Cys Pro Phe Leu Phe  Leu Met Leu Leu Gln  Asn Leu Lys 
    1190                 1195                 1200             


Leu Gly  Asp Asp Gln Tyr Val  Arg Ser Gly Lys Asp  His Val Ser 
    1205                 1210                 1215             


Thr Leu  Leu Thr Trp His Met  His Lys Leu Val Glu  Val Pro Phe 
    1220                 1225                 1230             


Pro Val  Val Asn Ala Met Met  Lys Ser Tyr Val Lys  Ser Lys Leu 
    1235                 1240                 1245             


Lys Leu  Leu Lys Gly Ser Gly  Thr Thr Val Thr Glu  Arg Ile Phe 
    1250                 1255                 1260             


Arg Glu  Tyr Phe Glu Met Gly  Val Val Pro Ser His  Ile Ser Ser 
    1265                 1270                 1275             


Leu Ile  Asp Met Gly Gln Gly  Ile Leu His Asn Ala  Ser Asp Phe 
    1280                 1285                 1290             


Tyr Gly  Leu Ile Ser Glu Arg  Phe Ile Asn Tyr Cys  Ile Gly Val 
    1295                 1300                 1305             


Ile Phe  Gly Glu Arg Pro Glu  Ala Tyr Thr Ser Ser  Asp Asp Gln 
    1310                 1315                 1320             


Ile Thr  Leu Phe Asp Lys Arg  Leu Ser Asp Leu Val  Asp Ser Asp 
    1325                 1330                 1335             


Pro Glu  Glu Val Leu Val Leu  Leu Glu Phe His Ser  His Leu Ser 
    1340                 1345                 1350             


Gly Leu  Leu Asn Lys Phe Ile  Ser Pro Lys Ser Val  Val Gly Arg 
    1355                 1360                 1365             


Phe Ala  Ala Glu Phe Lys Ser  Arg Phe Tyr Val Trp  Gly Glu Glu 
    1370                 1375                 1380             


Val Pro  Leu Leu Thr Lys Phe  Val Ser Ala Ala Leu  His Asn Val 
    1385                 1390                 1395             


Lys Cys  Lys Glu Pro His Gln  Leu Cys Glu Thr Ile  Asp Thr Ile 
    1400                 1405                 1410             


Ala Asp  Gln Ala Ile Ala Asn  Gly Val Pro Val Phe  Leu Val Asn 
    1415                 1420                 1425             


Cys Ile  Gln Arg Arg Thr Leu  Asp Leu Leu Lys Tyr  Ala Asn Phe 
    1430                 1435                 1440             


Pro Leu  Asp Pro Phe Leu Leu  Asn Thr His Thr Asp  Val Lys Asp 
    1445                 1450                 1455             


Trp Leu  Asp Gly Ser Arg Gly  Tyr Arg Ile Gln Arg  Leu Ile Glu 
    1460                 1465                 1470             


Glu Leu  Cys Pro Ser Glu Thr  Lys Ile Met Arg Lys  Leu Val Arg 
    1475                 1480                 1485             


Arg Leu  His His Lys Leu Lys  Asn Gly Glu Cys Asn  Glu Glu Phe 
    1490                 1495                 1500             


Phe Leu  Asp Leu Phe Asn Arg  Glu Lys Lys Glu Ala  Ile Leu Gln 
    1505                 1510                 1515             


Leu Gly  Glu Ile Leu Gly Leu  Glu Asp Asp Leu Asn  Glu Leu Ala 
    1520                 1525                 1530             


Ser Ile  Asn Trp Leu Asn Leu  Asn Glu Met Phe Pro  Leu Arg Met 
    1535                 1540                 1545             


Val Leu  Arg Gln Lys Val Val  Tyr Pro Ser Val Met  Thr Phe Gln 
    1550                 1555                 1560             


Glu Glu  Lys Ile Pro Ser Leu  Ile Lys Thr Leu Gln  Asn Lys Leu 
    1565                 1570                 1575             


Cys Ser  Lys Phe Thr Arg Gly  Ala Gln Lys Leu Leu  Ser Glu Ala 
    1580                 1585                 1590             


Ile Asn  Lys Ser Ala Phe Gln  Ser Cys Val Ser Ser  Gly Phe Ile 
    1595                 1600                 1605             


Gly Leu  Cys Lys Thr Leu Gly  Ser Arg Cys Val Arg  Asn Lys Asn 
    1610                 1615                 1620             


Arg Glu  Asn Met Tyr Ile Arg  Lys Val Leu Glu Asp  Leu Thr Met 
    1625                 1630                 1635             


Asp Glu  His Val Thr Arg Val  His Lys Gln Asp Gly  Val Met Leu 
    1640                 1645                 1650             


Tyr Ile  Cys Asp Lys Gln Arg  His Pro Glu Ala His  Arg Asp His 
    1655                 1660                 1665             


Ile Asn  Leu Leu Arg Pro Leu  Leu Trp Asp Tyr Ile  Cys Ile Ser 
    1670                 1675                 1680             


Leu Ser  Asn Ser Phe Glu Leu  Gly Val Trp Val Leu  Ala Glu Pro 
    1685                 1690                 1695             


Val Lys  Gly Lys Asn Glu Ser  Asn Ser Ala Val Arg  His Leu Asn 
    1700                 1705                 1710             


Pro Cys  Asp Tyr Val Ala Arg  Lys Pro Glu Ser Ser  Arg Leu Leu 
    1715                 1720                 1725             


Glu Asp  Lys Val Ser Leu Asn  His Val Ile Gln Ser  Val Arg Arg 
    1730                 1735                 1740             


Leu Tyr  Pro Lys Ile Phe Glu  Asp Gln Leu Leu Pro  Phe Met Phe 
    1745                 1750                 1755             


Asp Val  Ser Ser Lys Asn Met  Arg Trp Ser Pro Arg  Ile Lys Phe 
    1760                 1765                 1770             


Leu Asp  Leu Cys Val Leu Ile  Asp Ile Asn Ser Glu  Ser Leu Ser 
    1775                 1780                 1785             


Leu Ile  Ser His Val Val Lys  Trp Lys Arg Asp Glu  His Tyr Thr 
    1790                 1795                 1800             


Val Leu  Phe Ser Asp Leu Val  Asn Ser His Gln Arg  Ser Asp Ser 
    1805                 1810                 1815             


Ser Leu  Val Asp Glu Phe Val  Val Ser Thr Arg Asp  Val Cys Lys 
    1820                 1825                 1830             


Asn Phe  Leu Lys Gln Val Tyr  Phe Glu Ser Phe Val  Arg Glu Phe 
    1835                 1840                 1845             


Val Ala  Thr Ala Arg Thr Leu  Gly Asn Phe Ser Trp  Phe Pro His 
    1850                 1855                 1860             


Lys Asp  Met Met Pro Ser Glu  Asp Gly Ala Glu Ala  Leu Gly Pro 
    1865                 1870                 1875             


Phe Gln  Ser Phe Ile Leu Lys  Val Val Asn Lys Lys  Ile Glu Arg 
    1880                 1885                 1890             


Pro Met  Phe Arg Asn Asp Leu  Gln Phe Gly Phe Gly  Trp Phe Ser 
    1895                 1900                 1905             


Tyr Arg  Val Gly Asp Val Val  Cys Asn Ala Ala Met  Leu Ile Lys 
    1910                 1915                 1920             


Gln Gly  Leu Thr Asp Pro Lys  Ala Phe Lys Ser Leu  Arg Asp Leu 
    1925                 1930                 1935             


Trp Asp  Tyr Met Leu Ser Ser  Thr Glu Gly Ile Leu  Glu Phe Ser 
    1940                 1945                 1950             


Ile Thr  Val Asp Phe Thr His  Asn Gln Asn Asn Thr  Asp Cys Leu 
    1955                 1960                 1965             


Arg Lys  Phe Ser Leu Ile Phe  Val Val Lys Cys Gln  Leu Gln Ser 
    1970                 1975                 1980             


Pro Gly  Val Ala Asp Tyr Leu  Ser Cys Ser His Phe  Phe Lys Gly 
    1985                 1990                 1995             


Glu Val  Asp Arg Arg Leu Leu  Asp Glu Cys Leu Asn  Leu Leu Arg 
    2000                 2005                 2010             


Thr Asp  Pro Ile Phe Lys Ala  Asn Asp Gly Val Phe  Asp Ile Arg 
    2015                 2020                 2025             


Ser Glu  Glu Phe Glu Asp Tyr  Met Glu Asp Pro Leu  Thr Leu Gly 
    2030                 2035                 2040             


Asp Ser  Leu Glu Leu Glu Leu  Ile Gly Ser Arg Arg  Ile Leu Asn 
    2045                 2050                 2055             


Glu Ile  Lys Ser Thr Asp Phe  Glu Arg Ile Gly Pro  Glu Trp Glu 
    2060                 2065                 2070             


Pro Val  Pro Leu Thr Ile Arg  Lys Gly Ala Leu Phe  Glu Gly Arg 
    2075                 2080                 2085             


Asn Phe  Val Gln Asn Ile Ser  Val Lys Leu Glu Thr  Lys Asp Met 
    2090                 2095                 2100             


Arg Val  Phe Leu Ala Glu Leu  Glu Gly Cys Gly Lys  Ile Gly Asp 
    2105                 2110                 2115             


Val Leu  Gly Ser Leu Leu Leu  His Arg Phe Arg Thr  Gly Glu His 
    2120                 2125                 2130             


Leu Met  Glu Ser Glu Ile Ser  Thr Val Leu Gln Glu  Leu Cys Met 
    2135                 2140                 2145             


Asp Arg  Ser Val Met Leu Thr  Pro Leu Ser Phe Val  Pro Asp Trp 
    2150                 2155                 2160             


Phe Thr  Phe Arg Asp Cys Arg  Leu Cys Phe Ser Arg  Ser Lys Asn 
    2165                 2170                 2175             


Thr Val  Met Tyr Glu Thr Thr  Gly Gly Arg Phe Arg  Leu Lys Gly 
    2180                 2185                 2190             


Lys Ser  Cys Asp Asp Trp Leu  Ala Glu Arg Val Ala  Glu Glu Ile 
    2195                 2200                 2205             


Asp 
    


<210>  8
<211>  6630
<212>  DNA
<213>  Lymphocytic choriomeningitis virus


<220>
<221>  MISC_FEATURE
<223>  Lymphocytic choriomeningitis virus Wildtype L-Protein; ssrna 
       ambisense-strand viruses; arenaviridae; arenavirus; old world 
       arenaviruses

<400>  8
atggatgaaa ctattgcaga tttgagagag ttgtgtctaa attacataga acaggacgag       60

aggctgtcaa ggcaaaaact caacttcctg ggacaaagag aacccagaat ggtgctaatt      120

gagggactca aattgttatc acgctgtata gagatagaca gtgcagacaa aagtggttgc      180

atacacaacc acgatgacaa atctgttgaa acaatcctaa tagactctgg gattgtgtgt      240

ccaggactgc cactcatcat ccctgatggt tataagttga ttgacaattc ccttattctt      300

cttgaatgtt ttgttagaag cacaccagct agttttgaaa agaagttcat tgaggacacc      360

aacaaactag catgcatcaa agaagatctt gctgttgcag gcatcacact ggttccaata      420

gtggatggtc gttgtgatta tgataacagt ttcatgccag aatgggtgaa ttttaagttc      480

agagacctcc tatttaaact cctggagtat tctagtcaag atgagaaagt ttttgaggag      540

tctgaatact tcaggctctg tgagtctctt aagaccactg ttgacaaacg ttccggcatg      600

gactcaatga aaattttgaa agacgcaaga tcatttcata acgatgagat tatgaaaatg      660

tgccacgatg gtgtcaaccc caacatgagt tgcgatgatg tggtctttgg cataaattcc      720

ttttttggca ggtttaggag ggacctgtta aatgggaaac tcaaaaggaa tttccaaaag      780

gtcagccctg ggggcttaat caaggaattc tctgaacttt atgaaaccct tactgataat      840

gatgacatat taatgttgag caaagaggca gttgaatcct gccccttaat gaggttcatt      900

acagcagaga cccatgggca tgagagagga agcgatgcta acactgagta tgaaaggcta      960

ctctctatgt tgaacaaggt gaaaagttta aaattattaa acactagaag gagacagctg     1020

ctgaacttag atgtcttatg tctttcttca cttattaagc agtcaatttc caaagggttg     1080

gaaaatgata aacattgggt tggttgttgc tacagtagtg tgaatgatag gcttgtgagc     1140

cttcaaagta ccaaagaaga attcatgaga cttttgaaga acagaagaaa atcaagagtg     1200

cacaaaaagg catctcttga tgagcttttt agggtatcca taaatgagtt catagcaaaa     1260

atccagaaat gcctatcaac agtgggactt agttttgagc attacggact atcagaatgc     1320

ctcgtgcaag aatgccatat accatttgct gaatttgaga actttatgag agccgggact     1380

catcctgtaa tgcattacac aaaatttgaa gattacactt tccagcctaa catagagcaa     1440

ttgaggggtt tacagagttt gagaaaactg tcatctgttt gtttggctct aacaaacagc     1500

atgaaaacaa gctcagttgc aaggttgaga cagaaccaac tggggtctgt gagatatcaa     1560

gtggtggagt gcaaagaggt gttttgccag ataataaaac tggattccga agagtatcat     1620

ctactatatc agaaaactgg agaatcatcg aggtgttatt ccatacaagg tccggatggt     1680

cacttgattt ccttttacgc agatccaaaa aggttctttt taccaatttt ttcagatgag     1740

gtgttgcaca acatgataga cacaatgatt tcatggatta ggtcatgccc tgacttaaaa     1800

gattctctta ttgacattga gactgcacta aggacattga tcctactgat gctcaccaac     1860

ccaacaaaga gaaatcaaaa gcaggttcaa aatattaggt atttagtgat ggccatcgtc     1920

tcagactttt catcgacctc attaatggat aagttgaagg aggatctaat cacacctgcc     1980

gagaaagtgg tgtacaggct gcttcggttt ttgattagga caatttttgg tactggtgaa     2040

aaggtgttat tgagtgcaaa attcaagttt atgttgaatg tgtcatacct gtgtcatttg     2100

atcacaaagg agacccctga tagattgaca gatcagataa aatgttttga aaagttcttt     2160

gagcccaaga gtgagtttgg tttctttgtc aaccctaagg aaacaatcac acccgaagag     2220

gaatgtgttt tttatgaaca aatgaagaag ttcaccggta aagatattga ttgtcagcat     2280

tcaacccctg gtgttaattt agagatcttt agcatgatgg tatcttcatt caacaatggc     2340

accttaattc taaaagggga gaaaaggctc aacaatctgg accccatgac caactctgga     2400

tgtgcgacag cattagatct cgcaagcaac aaaagtgtgg ttgtcaataa acatctgaat     2460

ggagaacggc ttttggagta tgattttaac aaattgcttg ttagtgctgt gagccaaatt     2520

acagagggct tcatgaggaa acaaaagtat aagctgagac actcagatta cgaatataag     2580

gtctcaaagc ttgtctctag attagtcatc ggttccagga aaacagaagt agacaaattg     2640

gaagatgatc cggtagatgt gtgtttcgag ggggaggagg agacaagttt tttcaggagt     2700

ttagaagata aggtcagctc cacaataaca cggtataata gaggcactag gcttaatgaa     2760

gggcaagggg agggagaatt caagaacaca aaaggactac accaccttca gattattttg     2820

tcaggtaaaa gagcttatct gaggaaagtc attttatcag aaatttcatt tcatctagta     2880

gaggactttg atccatcctg tctcaccaat gacgacatga ggtttatttg tgaggctgtt     2940

gaaggttcaa cagaactgtc accattgtat tttacatcag ctgtcaaaga acaatgtggt     3000

ctggatgaga tggcaagaaa cctctgtaga aagttcttct cagagggtga ttggttctca     3060

tgtatgaaga tgatcttgtt acagatgaat gcaaatgcgt attcagggaa gtacagacac     3120

atgcagaggc agagcttaaa ttttaaattt gactgggaca aattggaaga agatgtaaga     3180

attagtgaaa gggaaagcaa ttctgaatct ctaagtaagg ccctttcatt gacaaaatgc     3240

atgagtgctg ctctaaagaa tctgtgtttt tactcagaag aatcaccaac atcatacact     3300

tcagttggcc ctgactctgg gagactaaaa tttgcattgt catacaaaga gcaggttggg     3360

ggaaatagag agctttacat tggggatttg aggacaaaaa tgttcacaag attggtagaa     3420

gattattttg aatccttttc tagtttcttt tcaggatctt gtttaaacaa tgacaaagag     3480

tttgaaaatg caatcttgtc aatgactatc aatgtgagag aagggttgtt aaactacagc     3540

atggatcaca gcaaatgggg accaatgatg tgcccattcc tattcttaat gcttctccaa     3600

aatctcaaac tgggtgatga tcagtacgtg cgttctggaa aagatcatgt tagcaccttg     3660

ttgacttggc atatgcataa acttgttgaa gtccctttcc ctgttgtgaa tgcaatgatg     3720

aaatcatatg ttaaatcaaa actcaagctt ctcaaagggt caggaacgac tgttacggag     3780

agaatcttta gagagtattt tgaaatgggg gtggtgccat ctcacatatc tagtctcatt     3840

gacatgggac aggggatcct acacaatgct tctgattttt acggtttaat tagtgaaagg     3900

tttatcaatt attgtattgg tgtcattttt ggagagaggc cagaagccta tacatcaagt     3960

gatgatcaga tcactttatt tgacaagaga ttgagtgact tagttgatag tgacccagaa     4020

gaagtccttg tcttgctgga attccactct cacttaagtg gtttgttgaa caagttcatc     4080

agtccaaaaa gtgtggttgg gcggtttgca gcggaattca aatccagatt ttatgtgtgg     4140

ggggaggagg tccctctcct cacgaaattt gtgtctgcgg cactacacaa tgttaagtgt     4200

aaagaaccgc atcaactttg tgagacaata gatacgattg ctgatcaagc tatagcaaat     4260

ggagttccag tttttttagt aaactgtatc cagaggagga cactggatct cttgaaatat     4320

gctaatttcc ctttagatcc attcttgtta aacactcaca ctgatgtaaa ggattggtta     4380

gatggttcta gaggttatag aatccaaaga ctcattgaag aattgtgtcc cagtgaaaca     4440

aagatcatga gaaaacttgt aagaagacta catcacaaac tcaagaacgg tgaatgtaac     4500

gaggaatttt ttctagacct cttcaacagg gaaaagaaag aggccatcct tcaattggga     4560

gagattcttg gtcttgagga tgatcttaat gagttggcaa gcatcaattg gttgaatctg     4620

aatgaaatgt tcccattgag gatggttctg agacaaaaag tggtttaccc atcagtaatg     4680

acctttcaag aggaaaagat cccctcattg attaaaacac tccaaaataa gctttgtagt     4740

aagttcacaa gaggtgcaca gaagctgttg tcagaggcaa tcaacaaatc agcttttcag     4800

agttgtgtct catccggctt tataggtctc tgtaagactt taggaagtag gtgtgtgaga     4860

aataaaaaca gggaaaatat gtatatcaga aaggtgcttg aagatctgac catggatgaa     4920

catgtcacaa gggttcacaa acaagatggt gtgatgttgt acatttgcga caagcagaga     4980

cacccagagg ctcaccgtga ccacatcaac cttttgaggc cccttctctg ggactacatt     5040

tgcatctcat tgagcaactc ttttgagctg ggtgtttggg ttttagcaga acctgtgaaa     5100

ggaaagaacg agagtaattc ggctgttagg cacttaaatc catgtgatta tgtagcaaga     5160

aaacctgaga gttcgagact actagaggat aaagtgagtt tgaatcatgt aattcaatct     5220

gtgaggcgac tgtaccccaa aatctttgag gatcagttgc tcccattcat gtctgatgtg     5280

agctcaaaaa atatgagatg gagtcccagg attaaattcc ttgacctttg tgtgctgatt     5340

gacatcaact cagagtcttt gtcactcatt tctcatgttg tcaaatggaa gagggacgaa     5400

cattacactg tgctgttttc tgatctcgtc aactctcacc aacggtcaga ctcaagttta     5460

gttgatgaat ttgttgtcag cacaagggat gtctgcaaga actttttgaa gcaagtgtat     5520

ttcgaatcat ttgtacgaga gtttgttgca acagctagga ccttaggtaa cttttcatgg     5580

ttcccccata aggacatgat gccatctgaa gatggcgctg aagcactggg acccttccaa     5640

tcatttattt tgaaagtggt gaacaagaaa atagagaggc ccatgtttag gaatgacttg     5700

cagtttggtt ttggttggtt ctcttatcgt gtgggggatg ttgtgtgtaa tgccgctatg     5760

ttaattaagc agggtttgac agatccaaaa gcatttaaat ctttaagaga tttgtgggat     5820

tacatgctca gcagcacaga ggggatattg gagttctcaa tcacagtgga tttcacacac     5880

aaccagaaca acactgactg cttgaggaaa ttttcattga tctttgtggt taaatgccaa     5940

ttacagagtc caggtgtagc tgattactta tcgtgctctc atttcttcaa aggtgaggtt     6000

gacaggagat tattagatga gtgtctcaat ctgttgagga cagaccccat ctttaaagcg     6060

aatgatggag tctttgacat taggtctgaa gagtttgaag attacatgga agaccctttg     6120

acacttggtg attcactaga acttgaacta ataggttcta gaaggattct gaatgagatc     6180

aaatctactg actttgagag gatagggcct gagtgggaac ctgtgcctct gaccataagg     6240

aagggtgccc tctttgaggg gaggaacttt gttcagaata tctctgtgaa attggagaca     6300

aaggacatga gggtctttct ggcagagctc gagggctgtg gaaaaattgg tgatgtcctc     6360

ggcagcctcc tcctgcaccg attcagaact ggtgagcact tgatggagtc agaaataagt     6420

acagttcttc aggagctctg catggacaga tccgtcatgc tgacaccatt atcttttgtg     6480

ccagattggt tcaccttcag agattgtagg ctctgcttca gcaggtcaaa gaacactgta     6540

atgtatgaga caactggggg caggttcaga ctcaagggga aatcctgtga cgattggctg     6600

gcggagcggg tggccgagga gatcgactag                                      6630


<210>  9
<211>  1497
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (strain WE)

<400>  9
atgggtcaga ttgtgacaat gtttgaggct ttgcctcaca tcattgatga ggtcatcaac       60

attgtcatta ttgtgctcat tataatcacg agcatcaaag ctgtgtacaa tttcgccacc      120

tgtgggatat tagcactggt cagcttcctt tttttggctg gtaggtcctg tggcatgtac      180

ggccttaatg gtcccgacat ctataaaggg gtttaccagt tcaaatcagt ggagtttgat      240

atgtctcact taaatctgac gatgcccaat gcgtgctcag ccaacaactc tcatcactac      300

atcagtatgg gaagctctgg actggagcta actttcacta acgactccat ccttaatcac      360

aatttttgca acttaacctc cgctttcaac aaaaagactt ttgaccatac actcatgagt      420

atagtctcga gtctgcacct cagtattaga gggaattcca accacaaagc agtgtcttgt      480

gattttaaca atggcatcac cattcaatac aacttgtcat tttcggaccc acagagcgct      540

ataagccagt gtaggacttt cagaggtaga gtcttggaca tgtttagaac tgcctttgga      600

ggaaaataca tgagaagtgg ctggggctgg gcaggttcag atggcaagac cacttggtgc      660

agccaaacaa gctatcagta cctaatcata caaaacagga cttgggaaaa ccactgtaga      720

tatgcaggcc cttttgggat gtctagaatc ctctttgctc aggaaaagac aaagtttctc      780

actaggagac ttgcaggcac attcacctgg accctgtcag actcctcagg agtagaaaat      840

ccaggtggtt attgcctgac caaatggatg atccttgctg cagagctcaa atgttttggg      900

aatacagctg ttgcaaaatg taatgtcaat catgatgaag agttctgtga catgctacga      960

ctaattgatt acaacaaggc cgccctgagt aagttcaagc aagatgtaga gtctgccttg     1020

catgtattca aaacaacagt aaattctctg atttccgatc agctgttgat gaggaatcat     1080

ctaagagatc taatgggggt accatactgt aattactcaa agttctggta tctggaacat     1140

gctaagactg gtgagactag tgtacccaag tgctggcttg tcactaatgg ctcctacttg     1200

aatgagaccc actttagtga tcaaatcgaa caagaagcag ataacatgat cacagagatg     1260

ttgaggaagg actacataaa aagacaaggg agtactcctt tagccttaat ggatcttttg     1320

atgttttcaa catcagcata tctaatcagc atctttctgc atcttgtgaa gataccaaca     1380

catagacaca taaagggcgg ttcatgtcca aagccacacc gcttgaccaa caaggggatc     1440

tgtagttgtg gtgcattcaa ggtgcctggt gtaaaaacta tctggaaaag acgctga        1497


<210>  10
<211>  498
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (strain WE)

<400>  10

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Asn Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Ser Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Leu Asn His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn His Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Ser Phe Ser Asp 
                165                 170                 175     


Pro Gln Ser Ala Ile Ser Gln Cys Arg Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Ala Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Arg 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Phe Ala Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Gln Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Val Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Ile Trp Lys 
                485                 490                 495     


Arg Arg 
        


<210>  11
<211>  1677
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (strain WE)

<400>  11
atgtctttgt ccaaagaagt caaaagcttt cagtggacac aggcgttgag gagggagttg       60

cagagtttta catcagatgt aaaggctgcc gtcatcaagg acgcaaccag tcttctaaat      120

gggttggact tttctgaagt cagcaacgtt cagaggatca tgagaaagga aaggagggat      180

gataaagact tgcagagact caggagtctt aaccagactg tgcattctct tgttgatctg      240

aagtctacat caaagaaaaa tgttctgaaa gtgggaagac ttagtgcaga ggaattgatg      300

acccttgcag ctgatcttga gaagctgaag gccaaaatta tgagaactga gaggcctcaa      360

gcttctggag tctacatggg aaatttgaca gcacaacaac ttgatcaaag atcccaaata      420

ctgcaaatgg ttgggatgag aagacctcag cagggtgcaa gtggtgtagt aagggtttgg      480

gatgtgaagg actcatcact tctgaacaat cagttcggca caatgccaag cctgacaatg      540

gcttgcatgg caaaacagtc acagacccca ctcaatgatg ttgtgcaggc actcacagac      600

cttggcttac tttacacagt caaatacccg aatctcagtg atcttgaaag gctaaaggat      660

aaacacccag ttctgggggt cattactgaa cagcaatcta gtatcaatat ctctggttat      720

aatttcagtc ttggtgcagc tgtgaaagcg ggggcagctc tgctagatgg agggaacatg      780

ctggaatcta tcttgatcaa accgagcaac agtgaggatc tcctaaaagc agtcctcggg      840

gccaagaaga aactcaacat gtttgtctca gatcaagttg gagatagaaa tccctatgaa      900

aacatccttt ataaagtctg tctttcaggt gaaggatggc catacatagc ctgtagaacg      960

tcagttgtgg ggagagcatg ggagaacaca acaattgatc tcacaaatga aaaacttgtt     1020

gccaactcat ctaggccagt gcctggagca gcaggcccac ctcaggtggg cttgagttac     1080

agtcagacaa tgctgttgaa agacttgatg ggagggattg atcccaatgc tcccacatgg     1140

attgacattg agggcaggtt caatgatcca gtggagatag caatattcca accacaaaat     1200

gggcaattca tacattttta cagggaacct acggaccaga agcaattcaa gcaggactca     1260

aagtattcac acggcatgga tcttgctgat ctcttcaatg cacagcctgg gctgacctca     1320

tcagttatag gtgctctccc acaagggatg gttttgagct gtcaaggttc tgatgacatc     1380

agaaagcttc tggactcaca aaatagaagg gacataaaac tcattgatgt tgagatgacc     1440

aaggaggcct caagagaata tgaagataaa gtgtgggaca aatatggctg gctatgcaaa     1500

atgcacactg gggtagtgag agacaaaaag aagaaagaga tcaccccaca ctgtgcactc     1560

atggactgca tcatttttga gagtgcttcc aaggcaagac tccctgatct aaaaaccgtt     1620

cacaacatcc tgccacatga tttaatcttc agaggaccca atgttgtgac actctaa        1677


<210>  12
<211>  558
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (strain WE)

<400>  12

Met Ser Leu Ser Lys Glu Val Lys Ser Phe Gln Trp Thr Gln Ala Leu 
1               5                   10                  15      


Arg Arg Glu Leu Gln Ser Phe Thr Ser Asp Val Lys Ala Ala Val Ile 
            20                  25                  30          


Lys Asp Ala Thr Ser Leu Leu Asn Gly Leu Asp Phe Ser Glu Val Ser 
        35                  40                  45              


Asn Val Gln Arg Ile Met Arg Lys Glu Arg Arg Asp Asp Lys Asp Leu 
    50                  55                  60                  


Gln Arg Leu Arg Ser Leu Asn Gln Thr Val His Ser Leu Val Asp Leu 
65                  70                  75                  80  


Lys Ser Thr Ser Lys Lys Asn Val Leu Lys Val Gly Arg Leu Ser Ala 
                85                  90                  95      


Glu Glu Leu Met Thr Leu Ala Ala Asp Leu Glu Lys Leu Lys Ala Lys 
            100                 105                 110         


Ile Met Arg Thr Glu Arg Pro Gln Ala Ser Gly Val Tyr Met Gly Asn 
        115                 120                 125             


Leu Thr Ala Gln Gln Leu Asp Gln Arg Ser Gln Ile Leu Gln Met Val 
    130                 135                 140                 


Gly Met Arg Arg Pro Gln Gln Gly Ala Ser Gly Val Val Arg Val Trp 
145                 150                 155                 160 


Asp Val Lys Asp Ser Ser Leu Leu Asn Asn Gln Phe Gly Thr Met Pro 
                165                 170                 175     


Ser Leu Thr Met Ala Cys Met Ala Lys Gln Ser Gln Thr Pro Leu Asn 
            180                 185                 190         


Asp Val Val Gln Ala Leu Thr Asp Leu Gly Leu Leu Tyr Thr Val Lys 
        195                 200                 205             


Tyr Pro Asn Leu Ser Asp Leu Glu Arg Leu Lys Asp Lys His Pro Val 
    210                 215                 220                 


Leu Gly Val Ile Thr Glu Gln Gln Ser Ser Ile Asn Ile Ser Gly Tyr 
225                 230                 235                 240 


Asn Phe Ser Leu Gly Ala Ala Val Lys Ala Gly Ala Ala Leu Leu Asp 
                245                 250                 255     


Gly Gly Asn Met Leu Glu Ser Ile Leu Ile Lys Pro Ser Asn Ser Glu 
            260                 265                 270         


Asp Leu Leu Lys Ala Val Leu Gly Ala Lys Lys Lys Leu Asn Met Phe 
        275                 280                 285             


Val Ser Asp Gln Val Gly Asp Arg Asn Pro Tyr Glu Asn Ile Leu Tyr 
    290                 295                 300                 


Lys Val Cys Leu Ser Gly Glu Gly Trp Pro Tyr Ile Ala Cys Arg Thr 
305                 310                 315                 320 


Ser Val Val Gly Arg Ala Trp Glu Asn Thr Thr Ile Asp Leu Thr Asn 
                325                 330                 335     


Glu Lys Leu Val Ala Asn Ser Ser Arg Pro Val Pro Gly Ala Ala Gly 
            340                 345                 350         


Pro Pro Gln Val Gly Leu Ser Tyr Ser Gln Thr Met Leu Leu Lys Asp 
        355                 360                 365             


Leu Met Gly Gly Ile Asp Pro Asn Ala Pro Thr Trp Ile Asp Ile Glu 
    370                 375                 380                 


Gly Arg Phe Asn Asp Pro Val Glu Ile Ala Ile Phe Gln Pro Gln Asn 
385                 390                 395                 400 


Gly Gln Phe Ile His Phe Tyr Arg Glu Pro Thr Asp Gln Lys Gln Phe 
                405                 410                 415     


Lys Gln Asp Ser Lys Tyr Ser His Gly Met Asp Leu Ala Asp Leu Phe 
            420                 425                 430         


Asn Ala Gln Pro Gly Leu Thr Ser Ser Val Ile Gly Ala Leu Pro Gln 
        435                 440                 445             


Gly Met Val Leu Ser Cys Gln Gly Ser Asp Asp Ile Arg Lys Leu Leu 
    450                 455                 460                 


Asp Ser Gln Asn Arg Arg Asp Ile Lys Leu Ile Asp Val Glu Met Thr 
465                 470                 475                 480 


Lys Glu Ala Ser Arg Glu Tyr Glu Asp Lys Val Trp Asp Lys Tyr Gly 
                485                 490                 495     


Trp Leu Cys Lys Met His Thr Gly Val Val Arg Asp Lys Lys Lys Lys 
            500                 505                 510         


Glu Ile Thr Pro His Cys Ala Leu Met Asp Cys Ile Ile Phe Glu Ser 
        515                 520                 525             


Ala Ser Lys Ala Arg Leu Pro Asp Leu Lys Thr Val His Asn Ile Leu 
    530                 535                 540                 


Pro His Asp Leu Ile Phe Arg Gly Pro Asn Val Val Thr Leu 
545                 550                 555             


<210>  13
<211>  273
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (strain WE)

<400>  13
atgggccaag gcaagtccaa agaagaaagg gacaccagca atacaggcag agcagagctt       60

ttgccagaca ccacctatct tggtcctcta aattgtaaat catgttggca gaaatttgac      120

agcttggtta gatgccatga ccactatctt tgcagacact gtctgaatct cctgctgtca      180

gtttccgaca gatgtcctct ctgtaagtat ccactgccaa ccaaactgaa ggtgtcaaca      240

gtcccaagct ccccacctcc ctatgaggag tga                                   273


<210>  14
<211>  90
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (strain WE)

<400>  14

Met Gly Gln Gly Lys Ser Lys Glu Glu Arg Asp Thr Ser Asn Thr Gly 
1               5                   10                  15      


Arg Ala Glu Leu Leu Pro Asp Thr Thr Tyr Leu Gly Pro Leu Asn Cys 
            20                  25                  30          


Lys Ser Cys Trp Gln Lys Phe Asp Ser Leu Val Arg Cys His Asp His 
        35                  40                  45              


Tyr Leu Cys Arg His Cys Leu Asn Leu Leu Leu Ser Val Ser Asp Arg 
    50                  55                  60                  


Cys Pro Leu Cys Lys Tyr Pro Leu Pro Thr Lys Leu Lys Val Ser Thr 
65                  70                  75                  80  


Val Pro Ser Ser Pro Pro Pro Tyr Glu Glu 
                85                  90  


<210>  15
<211>  6630
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (strain WE)

<400>  15
atggatgaaa ctattgcaga tttgagagag ttgtgtctaa attacataga acaggacgag       60

aggctgtcaa ggcaaaaact caacttcctg ggacaaagag aacccagaat ggtgctaatt      120

gagggactca aattgttatc acgctgtata gagatagaca gtgcagacaa aagtggttgc      180

atacacaacc acgatgacaa atctgttgaa acaatcctaa tagactctgg gattgtgtgt      240

ccaggactgc cactcatcat ccctgatggt tataagttga ttgacaattc ccttattctt      300

cttgaatgtt ttgttagaag cacaccagct agttttgaaa agaagttcat tgaggacacc      360

aacaaactag catgcatcaa agaagatctt gctgttgcag gcatcacact ggttccaata      420

gtggatggtc gttgtgatta tgataacagt ttcatgccag aatgggtgaa ttttaagttc      480

agagacctcc tatttaaact cctggagtat tctagtcaag atgagaaagt ttttgaggag      540

tctgaatact tcaggctctg tgagtctctt aagaccactg ttgacaaacg ttccggcatg      600

gactcaatga aaattttgaa agacgcaaga tcatttcata acgatgagat tatgaaaatg      660

tgccacgatg gtgtcaaccc caacatgagt tgcgatgatg tggtctttgg cataaattcc      720

ttttttggca ggtttaggag ggacctgtta aatgggaaac tcaaaaggaa tttccaaaag      780

gtcagccctg ggggcttaat caaggaattc tctgaacttt atgaaaccct tactgataat      840

gatgacatat taatgttgag caaagaggca gttgaatcct gccccttaat gaggttcatt      900

acagcagaga cccatgggca tgagagagga agcgatgcta acactgagta tgaaaggcta      960

ctctctatgt tgaacaaggt gaaaagttta aaattattaa acactagaag gagacagctg     1020

ctgaacttag atgtcttatg tctttcttca cttattaagc agtcaatttc caaagggttg     1080

gaaaatgata aacattgggt tggttgttgc tacagtagtg tgaatgatag gcttgtgagc     1140

cttcaaagta ccaaagaaga attcatgaga cttttgaaga acagaagaaa atcaagagtg     1200

cacaaaaagg catctcttga tgagcttttt agggtatcca taaatgagtt catagcaaaa     1260

atccagaaat gcctatcaac agtgggactt agttttgagc attacggact atcagaatgc     1320

ctcgtgcaag aatgccatat accatttgct gaatttgaga actttatgag agccgggact     1380

catcctgtaa tgcattacac aaaatttgaa gattacactt tccagcctaa catagagcaa     1440

ttgaggggtt tacagagttt gagaaaactg tcatctgttt gtttggctct aacaaacagc     1500

atgaaaacaa gctcagttgc aaggttgaga cagaaccaac tggggtctgt gagatatcaa     1560

gtggtggagt gcaaagaggt gttttgccag ataataaaac tggattccga agagtatcat     1620

ctactatatc agaaaactgg agaatcatcg aggtgttatt ccatacaagg tccggatggt     1680

cacttgattt ccttttacgc agatccaaaa aggttctttt taccaatttt ttcagatgag     1740

gtgttgcaca acatgataga cacaatgatt tcatggatta ggtcatgccc tgacttaaaa     1800

gattctctta ttgacattga gactgcacta aggacattga tcctactgat gctcaccaac     1860

ccaacaaaga gaaatcaaaa gcaggttcaa aatattaggt atttagtgat ggccatcgtc     1920

tcagactttt catcgacctc attaatggat aagttgaagg aggatctaat cacacctgcc     1980

gagaaagtgg tgtacaggct gcttcggttt ttgattagga caatttttgg tactggtgaa     2040

aaggtgttat tgagtgcaaa attcaagttt atgttgaatg tgtcatacct gtgtcatttg     2100

atcacaaagg agacccctga tagattgaca gatcagataa aatgttttga aaagttcttt     2160

gagcccaaga gtgagtttgg tttctttgtc aaccctaagg aaacaatcac acccgaagag     2220

gaatgtgttt tttatgaaca aatgaagaag ttcaccggta aagatattga ttgtcagcat     2280

tcaacccctg gtgttaattt agagatcttt agcatgatgg tatcttcatt caacaatggc     2340

accttaattc taaaagggga gaaaaggctc aacaatctgg accccatgac caactctgga     2400

tgtgcgacag cattagatct cgcaagcaac aaaagtgtgg ttgtcaataa acatctgaat     2460

ggagaacggc ttttggagta tgattttaac aaattgcttg ttagtgctgt gagccaaatt     2520

acagagggct tcatgaggaa acaaaagtat aagctgagac actcagatta cgaatataag     2580

gtctcaaagc ttgtctctag attagtcatc ggttccagga aaacagaagt agacaaattg     2640

gaagatgatc cggtagatgt gtgtttcgag ggggaggagg agacaagttt tttcaggagt     2700

ttagaagata aggtcagctc cacaataaca cggtataata gaggcactag gcttaatgaa     2760

gggcaagggg agggagaatt caagaacaca aaaggactac accaccttca gattattttg     2820

tcaggtaaaa gagcttatct gaggaaagtc attttatcag aaatttcatt tcatctagta     2880

gaggactttg atccatcctg tctcaccaat gacgacatga ggtttatttg tgaggctgtt     2940

gaaggttcaa cagaactgtc accattgtat tttacatcag ctgtcaaaga acaatgtggt     3000

ctggatgaga tggcaagaaa cctctgtaga aagttcttct cagagggtga ttggttctca     3060

tgtatgaaga tgatcttgtt acagatgaat gcaaatgcgt attcagggaa gtacagacac     3120

atgcagaggc agagcttaaa ttttaaattt gactgggaca aattggaaga agatgtaaga     3180

attagtgaaa gggaaagcaa ttctgaatct ctaagtaagg ccctttcatt gacaaaatgc     3240

atgagtgctg ctctaaagaa tctgtgtttt tactcagaag aatcaccaac atcatacact     3300

tcagttggcc ctgactctgg gagactaaaa tttgcattgt catacaaaga gcaggttggg     3360

ggaaatagag agctttacat tggggatttg aggacaaaaa tgttcacaag attggtagaa     3420

gattattttg aatccttttc tagtttcttt tcaggatctt gtttaaacaa tgacaaagag     3480

tttgaaaatg caatcttgtc aatgactatc aatgtgagag aagggttgtt aaactacagc     3540

atggatcaca gcaaatgggg accaatgatg tgcccattcc tattcttaat gcttctccaa     3600

aatctcaaac tgggtgatga tcagtacgtg cgttctggaa aagatcatgt tagcaccttg     3660

ttgacttggc atatgcataa acttgttgaa gtccctttcc ctgttgtgaa tgcaatgatg     3720

aaatcatatg ttaaatcaaa actcaagctt ctcaaagggt caggaacgac tgttacggag     3780

agaatcttta gagagtattt tgaaatgggg gtggtgccat ctcacatatc tagtctcatt     3840

gacatgggac aggggatcct acacaatgct tctgattttt acggtttaat tagtgaaagg     3900

tttatcaatt attgtattgg tgtcattttt ggagagaggc cagaagccta tacatcaagt     3960

gatgatcaga tcactttatt tgacaagaga ttgagtgact tagttgatag tgacccagaa     4020

gaagtccttg tcttgctgga attccactct cacttaagtg gtttgttgaa caagttcatc     4080

agtccaaaaa gtgtggttgg gcggtttgca gcggaattca aatccagatt ttatgtgtgg     4140

ggggaggagg tccctctcct cacgaaattt gtgtctgcgg cactacacaa tgttaagtgt     4200

aaagaaccgc atcaactttg tgagacaata gatacgattg ctgatcaagc tatagcaaat     4260

ggagttccag tttttttagt aaactgtatc cagaggagga cactggatct cttgaaatat     4320

gctaatttcc ctttagatcc attcttgtta aacactcaca ctgatgtaaa ggattggtta     4380

gatggttcta gaggttatag aatccaaaga ctcattgaag aattgtgtcc cagtgaaaca     4440

aagatcatga gaaaacttgt aagaagacta catcacaaac tcaagaacgg tgaatgtaac     4500

gaggaatttt ttctagacct cttcaacagg gaaaagaaag aggccatcct tcaattggga     4560

gagattcttg gtcttgagga tgatcttaat gagttggcaa gcatcaattg gttgaatctg     4620

aatgaaatgt tcccattgag gatggttctg agacaaaaag tggtttaccc atcagtaatg     4680

acctttcaag aggaaaagat cccctcattg attaaaacac tccaaaataa gctttgtagt     4740

aagttcacaa gaggtgcaca gaagctgttg tcagaggcaa tcaacaaatc agcttttcag     4800

agttgtgtct catccggctt tataggtctc tgtaagactt taggaagtag gtgtgtgaga     4860

aataaaaaca gggaaaatat gtatatcaga aaggtgcttg aagatctgac catggatgaa     4920

catgtcacaa gggttcacaa acaagatggt gtgatgttgt acatttgcga caagcagaga     4980

cacccagagg ctcaccgtga ccacatcaac cttttgaggc cccttctctg ggactacatt     5040

tgcatctcat tgagcaactc ttttgagctg ggtgtttggg ttttagcaga acctgtgaaa     5100

ggaaagaacg agagtaattc ggctgttagg cacttaaatc catgtgatta tgtagcaaga     5160

aaacctgaga gttcgagact actagaggat aaagtgagtt tgaatcatgt aattcaatct     5220

gtgaggcgac tgtaccccaa aatctttgag gatcagttgc tcccattcat gtctgatgtg     5280

agctcaaaaa atatgagatg gagtcccagg attaaattcc ttgacctttg tgtgctgatt     5340

gacatcaact cagagtcttt gtcactcatt tctcatgttg tcaaatggaa gagggacgaa     5400

cattacactg tgctgttttc tgatctcgtc aactctcacc aacggtcaga ctcaagttta     5460

gttgatgaat ttgttgtcag cacaagggat gtctgcaaga actttttgaa gcaagtgtat     5520

ttcgaatcat ttgtacgaga gtttgttgca acagctagga ccttaggtaa cttttcatgg     5580

ttcccccata aggacatgat gccatctgaa gatggcgctg aagcactggg acccttccaa     5640

tcatttattt tgaaagtggt gaacaagaaa atagagaggc ccatgtttag gaatgacttg     5700

cagtttggtt ttggttggtt ctcttatcgt gtgggggatg ttgtgtgtaa tgccgctatg     5760

ttaattaagc agggtttgac agatccaaaa gcatttaaat ctttaagaga tttgtgggat     5820

tacatgctca gcagcacaga ggggatattg gagttctcaa tcacagtgga tttcacacac     5880

aaccagaaca acactgactg cttgaggaaa ttttcattga tctttgtggt taaatgccaa     5940

ttacagagtc caggtgtagc tgattactta tcgtgctctc atttcttcaa aggtgaggtt     6000

gacaggagat tattagatga gtgtctcaat ctgttgagga cagaccccat ctttaaagcg     6060

aatgatggag tctttgacat taggtctgaa gagtttgaag attacatgga agaccctttg     6120

acacttggtg attcactaga acttgaacta ataggttcta gaaggattct gaatgagatc     6180

aaatctactg actttgagag gatagggcct gagtgggaac ctgtgcctct gaccataagg     6240

aagggtgccc tctttgaggg gaggaacttt gttcagaata tctctgtgaa attggagaca     6300

aaggacatga gggtctttct ggcagagctc gagggctgtg gaaaaattgg tgatgtcctc     6360

ggcagcctcc tcctgcaccg attcagaact ggtgagcact tgatggagtc agaaataagt     6420

acagttcttc aggagctctg catggacaga tccgtcatgc tgacaccatt atcttttgtg     6480

ccagattggt tcaccttcag agattgtagg ctctgcttca gcaggtcaaa gaacactgta     6540

atgtatgaga caactggggg caggttcaga ctcaagggga aatcctgtga cgattggctg     6600

gcggagcggg tggccgagga gatcgactag                                      6630


<210>  16
<211>  2209
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (strain WE)

<400>  16

Met Asp Glu Thr Ile Ala Asp Leu Arg Glu Leu Cys Leu Asn Tyr Ile 
1               5                   10                  15      


Glu Gln Asp Glu Arg Leu Ser Arg Gln Lys Leu Asn Phe Leu Gly Gln 
            20                  25                  30          


Arg Glu Pro Arg Met Val Leu Ile Glu Gly Leu Lys Leu Leu Ser Arg 
        35                  40                  45              


Cys Ile Glu Ile Asp Ser Ala Asp Lys Ser Gly Cys Ile His Asn His 
    50                  55                  60                  


Asp Asp Lys Ser Val Glu Thr Ile Leu Ile Asp Ser Gly Ile Val Cys 
65                  70                  75                  80  


Pro Gly Leu Pro Leu Ile Ile Pro Asp Gly Tyr Lys Leu Ile Asp Asn 
                85                  90                  95      


Ser Leu Ile Leu Leu Glu Cys Phe Val Arg Ser Thr Pro Ala Ser Phe 
            100                 105                 110         


Glu Lys Lys Phe Ile Glu Asp Thr Asn Lys Leu Ala Cys Ile Lys Glu 
        115                 120                 125             


Asp Leu Ala Val Ala Gly Ile Thr Leu Val Pro Ile Val Asp Gly Arg 
    130                 135                 140                 


Cys Asp Tyr Asp Asn Ser Phe Met Pro Glu Trp Val Asn Phe Lys Phe 
145                 150                 155                 160 


Arg Asp Leu Leu Phe Lys Leu Leu Glu Tyr Ser Ser Gln Asp Glu Lys 
                165                 170                 175     


Val Phe Glu Glu Ser Glu Tyr Phe Arg Leu Cys Glu Ser Leu Lys Thr 
            180                 185                 190         


Thr Val Asp Lys Arg Ser Gly Met Asp Ser Met Lys Ile Leu Lys Asp 
        195                 200                 205             


Ala Arg Ser Phe His Asn Asp Glu Ile Met Lys Met Cys His Asp Gly 
    210                 215                 220                 


Val Asn Pro Asn Met Ser Cys Asp Asp Val Val Phe Gly Ile Asn Ser 
225                 230                 235                 240 


Phe Phe Gly Arg Phe Arg Arg Asp Leu Leu Asn Gly Lys Leu Lys Arg 
                245                 250                 255     


Asn Phe Gln Lys Val Ser Pro Gly Gly Leu Ile Lys Glu Phe Ser Glu 
            260                 265                 270         


Leu Tyr Glu Thr Leu Thr Asp Asn Asp Asp Ile Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Ala Val Glu Ser Cys Pro Leu Met Arg Phe Ile Thr Ala Glu Thr 
    290                 295                 300                 


His Gly His Glu Arg Gly Ser Asp Ala Asn Thr Glu Tyr Glu Arg Leu 
305                 310                 315                 320 


Leu Ser Met Leu Asn Lys Val Lys Ser Leu Lys Leu Leu Asn Thr Arg 
                325                 330                 335     


Arg Arg Gln Leu Leu Asn Leu Asp Val Leu Cys Leu Ser Ser Leu Ile 
            340                 345                 350         


Lys Gln Ser Ile Ser Lys Gly Leu Glu Asn Asp Lys His Trp Val Gly 
        355                 360                 365             


Cys Cys Tyr Ser Ser Val Asn Asp Arg Leu Val Ser Leu Gln Ser Thr 
    370                 375                 380                 


Lys Glu Glu Phe Met Arg Leu Leu Lys Asn Arg Arg Lys Ser Arg Val 
385                 390                 395                 400 


His Lys Lys Ala Ser Leu Asp Glu Leu Phe Arg Val Ser Ile Asn Glu 
                405                 410                 415     


Phe Ile Ala Lys Ile Gln Lys Cys Leu Ser Thr Val Gly Leu Ser Phe 
            420                 425                 430         


Glu His Tyr Gly Leu Ser Glu Cys Leu Val Gln Glu Cys His Ile Pro 
        435                 440                 445             


Phe Ala Glu Phe Glu Asn Phe Met Arg Ala Gly Thr His Pro Val Met 
    450                 455                 460                 


His Tyr Thr Lys Phe Glu Asp Tyr Thr Phe Gln Pro Asn Ile Glu Gln 
465                 470                 475                 480 


Leu Arg Gly Leu Gln Ser Leu Arg Lys Leu Ser Ser Val Cys Leu Ala 
                485                 490                 495     


Leu Thr Asn Ser Met Lys Thr Ser Ser Val Ala Arg Leu Arg Gln Asn 
            500                 505                 510         


Gln Leu Gly Ser Val Arg Tyr Gln Val Val Glu Cys Lys Glu Val Phe 
        515                 520                 525             


Cys Gln Ile Ile Lys Leu Asp Ser Glu Glu Tyr His Leu Leu Tyr Gln 
    530                 535                 540                 


Lys Thr Gly Glu Ser Ser Arg Cys Tyr Ser Ile Gln Gly Pro Asp Gly 
545                 550                 555                 560 


His Leu Ile Ser Phe Tyr Ala Asp Pro Lys Arg Phe Phe Leu Pro Ile 
                565                 570                 575     


Phe Ser Asp Glu Val Leu His Asn Met Ile Asp Thr Met Ile Ser Trp 
            580                 585                 590         


Ile Arg Ser Cys Pro Asp Leu Lys Asp Ser Leu Ile Asp Ile Glu Thr 
        595                 600                 605             


Ala Leu Arg Thr Leu Ile Leu Leu Met Leu Thr Asn Pro Thr Lys Arg 
    610                 615                 620                 


Asn Gln Lys Gln Val Gln Asn Ile Arg Tyr Leu Val Met Ala Ile Val 
625                 630                 635                 640 


Ser Asp Phe Ser Ser Thr Ser Leu Met Asp Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Ile Thr Pro Ala Glu Lys Val Val Tyr Arg Leu Leu Arg Phe Leu Ile 
            660                 665                 670         


Arg Thr Ile Phe Gly Thr Gly Glu Lys Val Leu Leu Ser Ala Lys Phe 
        675                 680                 685             


Lys Phe Met Leu Asn Val Ser Tyr Leu Cys His Leu Ile Thr Lys Glu 
    690                 695                 700                 


Thr Pro Asp Arg Leu Thr Asp Gln Ile Lys Cys Phe Glu Lys Phe Phe 
705                 710                 715                 720 


Glu Pro Lys Ser Glu Phe Gly Phe Phe Val Asn Pro Lys Glu Thr Ile 
                725                 730                 735     


Thr Pro Glu Glu Glu Cys Val Phe Tyr Glu Gln Met Lys Lys Phe Thr 
            740                 745                 750         


Gly Lys Asp Ile Asp Cys Gln His Ser Thr Pro Gly Val Asn Leu Glu 
        755                 760                 765             


Ile Phe Ser Met Met Val Ser Ser Phe Asn Asn Gly Thr Leu Ile Leu 
    770                 775                 780                 


Lys Gly Glu Lys Arg Leu Asn Asn Leu Asp Pro Met Thr Asn Ser Gly 
785                 790                 795                 800 


Cys Ala Thr Ala Leu Asp Leu Ala Ser Asn Lys Ser Val Val Val Asn 
                805                 810                 815     


Lys His Leu Asn Gly Glu Arg Leu Leu Glu Tyr Asp Phe Asn Lys Leu 
            820                 825                 830         


Leu Val Ser Ala Val Ser Gln Ile Thr Glu Gly Phe Met Arg Lys Gln 
        835                 840                 845             


Lys Tyr Lys Leu Arg His Ser Asp Tyr Glu Tyr Lys Val Ser Lys Leu 
    850                 855                 860                 


Val Ser Arg Leu Val Ile Gly Ser Arg Lys Thr Glu Val Asp Lys Leu 
865                 870                 875                 880 


Glu Asp Asp Pro Val Asp Val Cys Phe Glu Gly Glu Glu Glu Thr Ser 
                885                 890                 895     


Phe Phe Arg Ser Leu Glu Asp Lys Val Ser Ser Thr Ile Thr Arg Tyr 
            900                 905                 910         


Asn Arg Gly Thr Arg Leu Asn Glu Gly Gln Gly Glu Gly Glu Phe Lys 
        915                 920                 925             


Asn Thr Lys Gly Leu His His Leu Gln Ile Ile Leu Ser Gly Lys Arg 
    930                 935                 940                 


Ala Tyr Leu Arg Lys Val Ile Leu Ser Glu Ile Ser Phe His Leu Val 
945                 950                 955                 960 


Glu Asp Phe Asp Pro Ser Cys Leu Thr Asn Asp Asp Met Arg Phe Ile 
                965                 970                 975     


Cys Glu Ala Val Glu Gly Ser Thr Glu Leu Ser Pro Leu Tyr Phe Thr 
            980                 985                 990         


Ser Ala Val Lys Glu Gln Cys Gly  Leu Asp Glu Met Ala  Arg Asn Leu 
        995                 1000                 1005             


Cys Arg  Lys Phe Phe Ser Glu  Gly Asp Trp Phe Ser  Cys Met Lys 
    1010                 1015                 1020             


Met Ile  Leu Leu Gln Met Asn  Ala Asn Ala Tyr Ser  Gly Lys Tyr 
    1025                 1030                 1035             


Arg His  Met Gln Arg Gln Ser  Leu Asn Phe Lys Phe  Asp Trp Asp 
    1040                 1045                 1050             


Lys Leu  Glu Glu Asp Val Arg  Ile Ser Glu Arg Glu  Ser Asn Ser 
    1055                 1060                 1065             


Glu Ser  Leu Ser Lys Ala Leu  Ser Leu Thr Lys Cys  Met Ser Ala 
    1070                 1075                 1080             


Ala Leu  Lys Asn Leu Cys Phe  Tyr Ser Glu Glu Ser  Pro Thr Ser 
    1085                 1090                 1095             


Tyr Thr  Ser Val Gly Pro Asp  Ser Gly Arg Leu Lys  Phe Ala Leu 
    1100                 1105                 1110             


Ser Tyr  Lys Glu Gln Val Gly  Gly Asn Arg Glu Leu  Tyr Ile Gly 
    1115                 1120                 1125             


Asp Leu  Arg Thr Lys Met Phe  Thr Arg Leu Val Glu  Asp Tyr Phe 
    1130                 1135                 1140             


Glu Ser  Phe Ser Ser Phe Phe  Ser Gly Ser Cys Leu  Asn Asn Asp 
    1145                 1150                 1155             


Lys Glu  Phe Glu Asn Ala Ile  Leu Ser Met Thr Ile  Asn Val Arg 
    1160                 1165                 1170             


Glu Gly  Leu Leu Asn Tyr Ser  Met Asp His Ser Lys  Trp Gly Pro 
    1175                 1180                 1185             


Met Met  Cys Pro Phe Leu Phe  Leu Met Leu Leu Gln  Asn Leu Lys 
    1190                 1195                 1200             


Leu Gly  Asp Asp Gln Tyr Val  Arg Ser Gly Lys Asp  His Val Ser 
    1205                 1210                 1215             


Thr Leu  Leu Thr Trp His Met  His Lys Leu Val Glu  Val Pro Phe 
    1220                 1225                 1230             


Pro Val  Val Asn Ala Met Met  Lys Ser Tyr Val Lys  Ser Lys Leu 
    1235                 1240                 1245             


Lys Leu  Leu Lys Gly Ser Gly  Thr Thr Val Thr Glu  Arg Ile Phe 
    1250                 1255                 1260             


Arg Glu  Tyr Phe Glu Met Gly  Val Val Pro Ser His  Ile Ser Ser 
    1265                 1270                 1275             


Leu Ile  Asp Met Gly Gln Gly  Ile Leu His Asn Ala  Ser Asp Phe 
    1280                 1285                 1290             


Tyr Gly  Leu Ile Ser Glu Arg  Phe Ile Asn Tyr Cys  Ile Gly Val 
    1295                 1300                 1305             


Ile Phe  Gly Glu Arg Pro Glu  Ala Tyr Thr Ser Ser  Asp Asp Gln 
    1310                 1315                 1320             


Ile Thr  Leu Phe Asp Lys Arg  Leu Ser Asp Leu Val  Asp Ser Asp 
    1325                 1330                 1335             


Pro Glu  Glu Val Leu Val Leu  Leu Glu Phe His Ser  His Leu Ser 
    1340                 1345                 1350             


Gly Leu  Leu Asn Lys Phe Ile  Ser Pro Lys Ser Val  Val Gly Arg 
    1355                 1360                 1365             


Phe Ala  Ala Glu Phe Lys Ser  Arg Phe Tyr Val Trp  Gly Glu Glu 
    1370                 1375                 1380             


Val Pro  Leu Leu Thr Lys Phe  Val Ser Ala Ala Leu  His Asn Val 
    1385                 1390                 1395             


Lys Cys  Lys Glu Pro His Gln  Leu Cys Glu Thr Ile  Asp Thr Ile 
    1400                 1405                 1410             


Ala Asp  Gln Ala Ile Ala Asn  Gly Val Pro Val Phe  Leu Val Asn 
    1415                 1420                 1425             


Cys Ile  Gln Arg Arg Thr Leu  Asp Leu Leu Lys Tyr  Ala Asn Phe 
    1430                 1435                 1440             


Pro Leu  Asp Pro Phe Leu Leu  Asn Thr His Thr Asp  Val Lys Asp 
    1445                 1450                 1455             


Trp Leu  Asp Gly Ser Arg Gly  Tyr Arg Ile Gln Arg  Leu Ile Glu 
    1460                 1465                 1470             


Glu Leu  Cys Pro Ser Glu Thr  Lys Ile Met Arg Lys  Leu Val Arg 
    1475                 1480                 1485             


Arg Leu  His His Lys Leu Lys  Asn Gly Glu Cys Asn  Glu Glu Phe 
    1490                 1495                 1500             


Phe Leu  Asp Leu Phe Asn Arg  Glu Lys Lys Glu Ala  Ile Leu Gln 
    1505                 1510                 1515             


Leu Gly  Glu Ile Leu Gly Leu  Glu Asp Asp Leu Asn  Glu Leu Ala 
    1520                 1525                 1530             


Ser Ile  Asn Trp Leu Asn Leu  Asn Glu Met Phe Pro  Leu Arg Met 
    1535                 1540                 1545             


Val Leu  Arg Gln Lys Val Val  Tyr Pro Ser Val Met  Thr Phe Gln 
    1550                 1555                 1560             


Glu Glu  Lys Ile Pro Ser Leu  Ile Lys Thr Leu Gln  Asn Lys Leu 
    1565                 1570                 1575             


Cys Ser  Lys Phe Thr Arg Gly  Ala Gln Lys Leu Leu  Ser Glu Ala 
    1580                 1585                 1590             


Ile Asn  Lys Ser Ala Phe Gln  Ser Cys Val Ser Ser  Gly Phe Ile 
    1595                 1600                 1605             


Gly Leu  Cys Lys Thr Leu Gly  Ser Arg Cys Val Arg  Asn Lys Asn 
    1610                 1615                 1620             


Arg Glu  Asn Met Tyr Ile Arg  Lys Val Leu Glu Asp  Leu Thr Met 
    1625                 1630                 1635             


Asp Glu  His Val Thr Arg Val  His Lys Gln Asp Gly  Val Met Leu 
    1640                 1645                 1650             


Tyr Ile  Cys Asp Lys Gln Arg  His Pro Glu Ala His  Arg Asp His 
    1655                 1660                 1665             


Ile Asn  Leu Leu Arg Pro Leu  Leu Trp Asp Tyr Ile  Cys Ile Ser 
    1670                 1675                 1680             


Leu Ser  Asn Ser Phe Glu Leu  Gly Val Trp Val Leu  Ala Glu Pro 
    1685                 1690                 1695             


Val Lys  Gly Lys Asn Glu Ser  Asn Ser Ala Val Arg  His Leu Asn 
    1700                 1705                 1710             


Pro Cys  Asp Tyr Val Ala Arg  Lys Pro Glu Ser Ser  Arg Leu Leu 
    1715                 1720                 1725             


Glu Asp  Lys Val Ser Leu Asn  His Val Ile Gln Ser  Val Arg Arg 
    1730                 1735                 1740             


Leu Tyr  Pro Lys Ile Phe Glu  Asp Gln Leu Leu Pro  Phe Met Ser 
    1745                 1750                 1755             


Asp Val  Ser Ser Lys Asn Met  Arg Trp Ser Pro Arg  Ile Lys Phe 
    1760                 1765                 1770             


Leu Asp  Leu Cys Val Leu Ile  Asp Ile Asn Ser Glu  Ser Leu Ser 
    1775                 1780                 1785             


Leu Ile  Ser His Val Val Lys  Trp Lys Arg Asp Glu  His Tyr Thr 
    1790                 1795                 1800             


Val Leu  Phe Ser Asp Leu Val  Asn Ser His Gln Arg  Ser Asp Ser 
    1805                 1810                 1815             


Ser Leu  Val Asp Glu Phe Val  Val Ser Thr Arg Asp  Val Cys Lys 
    1820                 1825                 1830             


Asn Phe  Leu Lys Gln Val Tyr  Phe Glu Ser Phe Val  Arg Glu Phe 
    1835                 1840                 1845             


Val Ala  Thr Ala Arg Thr Leu  Gly Asn Phe Ser Trp  Phe Pro His 
    1850                 1855                 1860             


Lys Asp  Met Met Pro Ser Glu  Asp Gly Ala Glu Ala  Leu Gly Pro 
    1865                 1870                 1875             


Phe Gln  Ser Phe Ile Leu Lys  Val Val Asn Lys Lys  Ile Glu Arg 
    1880                 1885                 1890             


Pro Met  Phe Arg Asn Asp Leu  Gln Phe Gly Phe Gly  Trp Phe Ser 
    1895                 1900                 1905             


Tyr Arg  Val Gly Asp Val Val  Cys Asn Ala Ala Met  Leu Ile Lys 
    1910                 1915                 1920             


Gln Gly  Leu Thr Asp Pro Lys  Ala Phe Lys Ser Leu  Arg Asp Leu 
    1925                 1930                 1935             


Trp Asp  Tyr Met Leu Ser Ser  Thr Glu Gly Ile Leu  Glu Phe Ser 
    1940                 1945                 1950             


Ile Thr  Val Asp Phe Thr His  Asn Gln Asn Asn Thr  Asp Cys Leu 
    1955                 1960                 1965             


Arg Lys  Phe Ser Leu Ile Phe  Val Val Lys Cys Gln  Leu Gln Ser 
    1970                 1975                 1980             


Pro Gly  Val Ala Asp Tyr Leu  Ser Cys Ser His Phe  Phe Lys Gly 
    1985                 1990                 1995             


Glu Val  Asp Arg Arg Leu Leu  Asp Glu Cys Leu Asn  Leu Leu Arg 
    2000                 2005                 2010             


Thr Asp  Pro Ile Phe Lys Ala  Asn Asp Gly Val Phe  Asp Ile Arg 
    2015                 2020                 2025             


Ser Glu  Glu Phe Glu Asp Tyr  Met Glu Asp Pro Leu  Thr Leu Gly 
    2030                 2035                 2040             


Asp Ser  Leu Glu Leu Glu Leu  Ile Gly Ser Arg Arg  Ile Leu Asn 
    2045                 2050                 2055             


Glu Ile  Lys Ser Thr Asp Phe  Glu Arg Ile Gly Pro  Glu Trp Glu 
    2060                 2065                 2070             


Pro Val  Pro Leu Thr Ile Arg  Lys Gly Ala Leu Phe  Glu Gly Arg 
    2075                 2080                 2085             


Asn Phe  Val Gln Asn Ile Ser  Val Lys Leu Glu Thr  Lys Asp Met 
    2090                 2095                 2100             


Arg Val  Phe Leu Ala Glu Leu  Glu Gly Cys Gly Lys  Ile Gly Asp 
    2105                 2110                 2115             


Val Leu  Gly Ser Leu Leu Leu  His Arg Phe Arg Thr  Gly Glu His 
    2120                 2125                 2130             


Leu Met  Glu Ser Glu Ile Ser  Thr Val Leu Gln Glu  Leu Cys Met 
    2135                 2140                 2145             


Asp Arg  Ser Val Met Leu Thr  Pro Leu Ser Phe Val  Pro Asp Trp 
    2150                 2155                 2160             


Phe Thr  Phe Arg Asp Cys Arg  Leu Cys Phe Ser Arg  Ser Lys Asn 
    2165                 2170                 2175             


Thr Val  Met Tyr Glu Thr Thr  Gly Gly Arg Phe Arg  Leu Lys Gly 
    2180                 2185                 2190             


Lys Ser  Cys Asp Asp Trp Leu  Ala Glu Arg Val Ala  Glu Glu Ile 
    2195                 2200                 2205             


Asp 
    


<210>  17
<211>  1497
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P42)

<400>  17
atgggtcaga ttgtgacaat gtttgaggct ttgcctcaca tcattgatga ggtcatcaac       60

attgtcatta ttgtgctcat tataatcacg agcatcaaag ctgtgtacaa tttcgccacc      120

tgtgggatat tagcactggt cagcttcctt tttttggctg gtaggtcctg tggcatgtac      180

ggccttaatg gtcccgacat ctataaaggg gtttaccagt tcaaatcagt ggagtttgat      240

atgtctcact taaatctgac gatgcccaat gcgtgctcag ccaacaactc tcatcactac      300

atcagtatgg gaagctctgg actggagcta actttcacta acgactccat ccttaatcac      360

aatttttgca acttaacctc cgctttcaac aaaaagactt ttgaccatac actcatgagt      420

atagtctcga gtctgcacct cagtattaga gggaattcca accacaaagc agtgtcttgt      480

gattttaaca atggcatcac cattcaatac aacttgtcat tttcggaccc acagagcgct      540

atgagccagt gtaggacttt cagaggtaga gtcttggaca tgtttagaac tgcctttgga      600

ggaaaataca tgagaagtgg ctggggctgg gcaggttcag atggcaagac cacttggtgc      660

agccaaacaa gctatcagta cctaatcata caaaacagga cttgggaaaa ccactgtaga      720

tatgcaggcc cttttgggat gtctagaatc ctctttgctc aggaaaagac aaagtttctc      780

actaggagac ttgcaggcac attcacctgg accctgtcag actcctcagg agtagaaaat      840

ccaggtggtt attgcctgac caaatggatg atccttgctg cagagctcaa atgttttggg      900

aatacagctg ttgcaaaatg taatgtcaat catgatgaag agttctgtga catgctacga      960

ctaattgatt acaacaaggc cgccctgagt aagttcaagc aagatgtaga gtctgccttg     1020

catgtattca aaacaacagt aaattctctg atttccgatc agctgttgat gaggaatcat     1080

ctaagagatc taatgggggt accatactgt aattactcaa agttctggta tctggaacat     1140

gctaagactg gtgagactag tgtacccaag tgctggcttg tcactaatgg ctcctacttg     1200

aatgagaccc actttagtga tcaaatcgaa caagaagcag ataacatgat cacagagatg     1260

ttgaggaagg actacataaa aagacaaggg agtactcctt tagccttaat ggatcttttg     1320

atgttttcaa catcagcata tctaatcagc atctttctgc atcttgtgaa gataccaaca     1380

catagacaca taaagggcgg ttcatgtcca aagccacacc gcttgaccaa caaggggatc     1440

tgtagttgtg gtgcattcaa ggtgcctggt gtaaaaacta tctggaaaag acgctga        1497


<210>  18
<211>  498
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P42)

<400>  18

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Asn Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Ser Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Leu Asn His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn His Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Ser Phe Ser Asp 
                165                 170                 175     


Pro Gln Ser Ala Met Ser Gln Cys Arg Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Ala Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Arg 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Phe Ala Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Gln Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Val Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Ile Trp Lys 
                485                 490                 495     


Arg Arg 
        


<210>  19
<211>  1677
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P42)

<400>  19
atgtctttgt ccaaagaagt caaaagcttt cagtggacac aggcgttgag gagggagttg       60

cagagtttta catcagatgt aaaggctgcc gtcatcaagg acgcaaccag tcttctaaat      120

gggttggact tttctgaagt cagcaacgtt cagaggatca tgagaaagga aaggagggat      180

gataaagact tgcagagact caggagtctt aaccagactg tgcattctct tgttgatctg      240

aagtctacat caaagaaaaa tgttctgaaa gtgggaagac ttagtgcaga ggaattgatg      300

acccttgcag ctgatcttga gaagctgaag gccaaaatta tgagaactga gaggcctcaa      360

gcttctggag tctacatggg aaatttgaca gcacaacaac ttgatcaaag atcccaaata      420

ctgcaaatgg ttgggatgag aagacctcag cagggtgcaa gtggtgtagt aagggtttgg      480

gatgtgaagg actcatcact tctgaacaat cagttcggca caatgccaag cctgacaatg      540

gcttgcatgg caaaacagtc acagacccca ctcaatgatg ttgtgcaggc actcacagac      600

cttggcttac tttacacagt caaatacccg aatctcagtg atcttgaaag gctaaaggat      660

aaacacccag ttctgggggt cattactgaa cagcaatcta gtatcaatat ctctggttat      720

aatttcagtc ttggtgcagc tgtgaaagcg ggggcagctc tgctagatgg agggaacatg      780

ctggaatcta tcttgatcaa accgagcaac agtgaggatc tcctaaaagc agtcctcggg      840

gccaagaaga aactcaacat gtttgtctca gatcaagttg gagatagaaa tccctatgaa      900

aacatccttt ataaagtctg tctttcaggt gaaggatggc catacatagc ctgtagaacg      960

tcagttgtgg ggagagcatg ggagaacaca acaattgatc tcacaaatga aaaacttgtt     1020

gccaactcat ctaggccagt gcctggagca gcaggcccac ctcaggtggg cttgagttac     1080

agtcagacaa tgctgttgaa agacttgatg ggagggattg atcccaatgc tcccacatgg     1140

attgacattg agggcaggtt caatgatcca gtggagatag caatattcca accacaaaat     1200

gggcaattca tacattttta cagggaacct acggaccaga agcaattcaa gcaggactca     1260

aagtattcac acggcatgga tcttgctgat ctcttcaatg cacagcctgg gctgacctca     1320

tcagttatag gtgctctccc acaagggatg gttttgagct gtcaaggttc tgatgacatc     1380

agaaagcttc tggactcaca aaatagaagg gacataaaac tcattgatgt tgagatgacc     1440

aaggaggcct caagagaata tgaagataaa gtgtgggaca aatatggctg gctatgcaaa     1500

atgcacactg gggtagtgag agacaaaaag aagaaagaga tcaccccaca ctgtgcactc     1560

atggactgca tcatttttga gagtgcttcc aaggcaagac tccctgatct aaaaaccgtt     1620

cacaacatcc tgccacatga tttaatcttc agaggaccca atgttgtgac actctaa        1677


<210>  20
<211>  558
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P42)

<400>  20

Met Ser Leu Ser Lys Glu Val Lys Ser Phe Gln Trp Thr Gln Ala Leu 
1               5                   10                  15      


Arg Arg Glu Leu Gln Ser Phe Thr Ser Asp Val Lys Ala Ala Val Ile 
            20                  25                  30          


Lys Asp Ala Thr Ser Leu Leu Asn Gly Leu Asp Phe Ser Glu Val Ser 
        35                  40                  45              


Asn Val Gln Arg Ile Met Arg Lys Glu Arg Arg Asp Asp Lys Asp Leu 
    50                  55                  60                  


Gln Arg Leu Arg Ser Leu Asn Gln Thr Val His Ser Leu Val Asp Leu 
65                  70                  75                  80  


Lys Ser Thr Ser Lys Lys Asn Val Leu Lys Val Gly Arg Leu Ser Ala 
                85                  90                  95      


Glu Glu Leu Met Thr Leu Ala Ala Asp Leu Glu Lys Leu Lys Ala Lys 
            100                 105                 110         


Ile Met Arg Thr Glu Arg Pro Gln Ala Ser Gly Val Tyr Met Gly Asn 
        115                 120                 125             


Leu Thr Ala Gln Gln Leu Asp Gln Arg Ser Gln Ile Leu Gln Met Val 
    130                 135                 140                 


Gly Met Arg Arg Pro Gln Gln Gly Ala Ser Gly Val Val Arg Val Trp 
145                 150                 155                 160 


Asp Val Lys Asp Ser Ser Leu Leu Asn Asn Gln Phe Gly Thr Met Pro 
                165                 170                 175     


Ser Leu Thr Met Ala Cys Met Ala Lys Gln Ser Gln Thr Pro Leu Asn 
            180                 185                 190         


Asp Val Val Gln Ala Leu Thr Asp Leu Gly Leu Leu Tyr Thr Val Lys 
        195                 200                 205             


Tyr Pro Asn Leu Ser Asp Leu Glu Arg Leu Lys Asp Lys His Pro Val 
    210                 215                 220                 


Leu Gly Val Ile Thr Glu Gln Gln Ser Ser Ile Asn Ile Ser Gly Tyr 
225                 230                 235                 240 


Asn Phe Ser Leu Gly Ala Ala Val Lys Ala Gly Ala Ala Leu Leu Asp 
                245                 250                 255     


Gly Gly Asn Met Leu Glu Ser Ile Leu Ile Lys Pro Ser Asn Ser Glu 
            260                 265                 270         


Asp Leu Leu Lys Ala Val Leu Gly Ala Lys Lys Lys Leu Asn Met Phe 
        275                 280                 285             


Val Ser Asp Gln Val Gly Asp Arg Asn Pro Tyr Glu Asn Ile Leu Tyr 
    290                 295                 300                 


Lys Val Cys Leu Ser Gly Glu Gly Trp Pro Tyr Ile Ala Cys Arg Thr 
305                 310                 315                 320 


Ser Val Val Gly Arg Ala Trp Glu Asn Thr Thr Ile Asp Leu Thr Asn 
                325                 330                 335     


Glu Lys Leu Val Ala Asn Ser Ser Arg Pro Val Pro Gly Ala Ala Gly 
            340                 345                 350         


Pro Pro Gln Val Gly Leu Ser Tyr Ser Gln Thr Met Leu Leu Lys Asp 
        355                 360                 365             


Leu Met Gly Gly Ile Asp Pro Asn Ala Pro Thr Trp Ile Asp Ile Glu 
    370                 375                 380                 


Gly Arg Phe Asn Asp Pro Val Glu Ile Ala Ile Phe Gln Pro Gln Asn 
385                 390                 395                 400 


Gly Gln Phe Ile His Phe Tyr Arg Glu Pro Thr Asp Gln Lys Gln Phe 
                405                 410                 415     


Lys Gln Asp Ser Lys Tyr Ser His Gly Met Asp Leu Ala Asp Leu Phe 
            420                 425                 430         


Asn Ala Gln Pro Gly Leu Thr Ser Ser Val Ile Gly Ala Leu Pro Gln 
        435                 440                 445             


Gly Met Val Leu Ser Cys Gln Gly Ser Asp Asp Ile Arg Lys Leu Leu 
    450                 455                 460                 


Asp Ser Gln Asn Arg Arg Asp Ile Lys Leu Ile Asp Val Glu Met Thr 
465                 470                 475                 480 


Lys Glu Ala Ser Arg Glu Tyr Glu Asp Lys Val Trp Asp Lys Tyr Gly 
                485                 490                 495     


Trp Leu Cys Lys Met His Thr Gly Val Val Arg Asp Lys Lys Lys Lys 
            500                 505                 510         


Glu Ile Thr Pro His Cys Ala Leu Met Asp Cys Ile Ile Phe Glu Ser 
        515                 520                 525             


Ala Ser Lys Ala Arg Leu Pro Asp Leu Lys Thr Val His Asn Ile Leu 
    530                 535                 540                 


Pro His Asp Leu Ile Phe Arg Gly Pro Asn Val Val Thr Leu 
545                 550                 555             


<210>  21
<211>  273
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P42)

<400>  21
atgggccaag gcaagtccaa agaagaaagg gacaccagca atacaggcag agcagagctt       60

ttgccagaca ccacctatct tggtcctcta aattgtaaat catgttggca gaaatttgac      120

agcttggtta gatgccatga ccactatctt tgcagacact gtctgaatct cctgctgtca      180

gtttccgaca gatgtcctct ctgtaagtat ccactgccaa ccaaactgaa ggtgtcaaca      240

gtcccaagct ccccacctcc ctatgaggag tga                                   273


<210>  22
<211>  90
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P42)

<400>  22

Met Gly Gln Gly Lys Ser Lys Glu Glu Arg Asp Thr Ser Asn Thr Gly 
1               5                   10                  15      


Arg Ala Glu Leu Leu Pro Asp Thr Thr Tyr Leu Gly Pro Leu Asn Cys 
            20                  25                  30          


Lys Ser Cys Trp Gln Lys Phe Asp Ser Leu Val Arg Cys His Asp His 
        35                  40                  45              


Tyr Leu Cys Arg His Cys Leu Asn Leu Leu Leu Ser Val Ser Asp Arg 
    50                  55                  60                  


Cys Pro Leu Cys Lys Tyr Pro Leu Pro Thr Lys Leu Lys Val Ser Thr 
65                  70                  75                  80  


Val Pro Ser Ser Pro Pro Pro Tyr Glu Glu 
                85                  90  


<210>  23
<211>  6630
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P42)

<400>  23
atggatgaaa ctattgcaga tttgagagag ttgtgtctaa attacataga acaggacgag       60

aggctgtcaa ggcaaaaact caacttcctg ggacaaagag aacccagaat ggtgctaatt      120

gagggactca aattgttatc acgctgtata gagatagaca gtgcagacaa aagtggttgc      180

atacacaacc acgatgacaa atctgttgaa acaatcctaa tagactctgg gattgtgtgt      240

ccaggactgc cactcatcat ccctgatggt tataagttga ttgacaattc ccttattctt      300

cttgaatgtt ttgttagaag cacaccagct agttttgaaa agaagttcat tgaggacacc      360

aacaaactag catgcatcaa agaagatctt gctgttgcag gcatcacact ggttccaata      420

gtggatggtc gttgtgatta tgataacagt ttcatgccag aatgggtgaa ttttaagttc      480

agagacctcc tatttaaact cctggagtat tctagtcaag atgagaaagt ttttgaggag      540

tctgaatact tcaggctctg tgagtctctt aagaccactg ttgacaaacg ttccggcatg      600

gactcaatga aaattttgaa agacgcaaga tcatttcata acgatgagat tatgaaaatg      660

tgccacgatg gtgtcaaccc caacatgagt tgcgatgatg tggtctttgg cataaattcc      720

ttttttggca ggtttaggag ggacctgtta aatgggaaac tcaaaaggaa tttccaaaag      780

gtcagccctg ggggcttaat caaggaattc tctgaacttt atgaaaccct tactgataat      840

gatgacatat taatgttgag caaagaggca gttgaatcct gccccttaat gaggttcatt      900

acagcagaga cccatgggca tgagagagga agcgatgcta acactgagta tgaaaggcta      960

ctctctatgt tgaacaaggt gaaaagttta aaattattaa acactagaag gagacagctg     1020

ctgaacttag atgtcttatg tctttcttca cttattaagc agtcaatttc caaagggttg     1080

gaaaatgata aacattgggt tggttgttgc tacagtagtg tgaatgatag gcttgtgagc     1140

cttcaaagta ccaaagaaga attcatgaga cttttgaaga acagaagaaa atcaagagtg     1200

cacaaaaagg catctcttga tgagcttttt agggtatcca taaatgagtt catagcaaaa     1260

atccagaaat gcctatcaac agtgggactt agttttgagc attacggact atcagaatgc     1320

ctcgtgcaag aatgccatat accatttgct gaatttgaga actttatgag agccgggact     1380

catcctgtaa tgcattacac aaaatttgaa gattacactt tccagcctaa catagagcaa     1440

ttgaggggtt tacagagttt gagaaaactg tcatctgttt gtttggctct aacaaacagc     1500

atgaaaacaa gctcagttgc aaggttgaga cagaaccaac tggggtctgt gagatatcaa     1560

gtggtggagt gcaaagaggt gttttgccag ataataaaac tggattccga agagtatcat     1620

ctactatatc agaaaactgg agaatcatcg aggtgttatt ccatacaagg tccggatggt     1680

cacttgattt ccttttacgc agatccaaaa aggttctttt taccaatttt ttcagatgag     1740

gtgttgcaca acatgataga cacaatgatt tcatggatta ggtcatgccc tgacttaaaa     1800

gattctctta ttgacattga gactgcacta aggacattga tcctactgat gctcaccaac     1860

ccaacaaaga gaaatcaaaa gcaggttcaa aatattaggt atttagtgat ggccatcgtc     1920

tcagactttt catcgacctc attaatggat aagttgaagg aggatctaat cacacctgcc     1980

gagaaagtgg tgtacaggct gcttcggttt ttgattagga caatttttgg tactggtgaa     2040

aaggtgttat tgagtgcaaa attcaagttt atgttgaatg tgtcatacct gtgtcatttg     2100

atcacaaagg agacccctga tagattgaca gatcagataa aatgttttga aaagttcttt     2160

gagcccaaga gtgagtttgg tttctttgtc aaccctaagg aaacaatcac acccgaagag     2220

gaatgtgttt tttatgaaca aatgaagaag ttcaccggta aagatattga ttgtcagcat     2280

tcaacccctg gtgttaattt agagatcttt agcatgatgg tatcttcatt caacaatggc     2340

accttaattc taaaagggga gaaaaggctc aacaatctgg accccatgac caactctgga     2400

tgtgcgacag cattagatct cgcaagcaac aaaagtgtgg ttgtcaataa acatctgaat     2460

ggagaacggc ttttggagta tgattttaac aaattgcttg ttagtgctgt gagccaaatt     2520

acagagggct tcatgaggaa acaaaagtat aagctgagac actcagatta cgaatataag     2580

gtctcaaagc ttgtctctag attagtcatc ggttccagga aaacagaagt agacaaattg     2640

gaagatgatc cggtagatgt gtgtttcgag ggggaggagg agacaagttt tttcaggagt     2700

ttagaagata aggtcagctc cacaataaca cggtataata gaggcactag gcttaatgaa     2760

gggcaagggg agggagaatt caagaacaca aaaggactac accaccttca gattattttg     2820

tcaggtaaaa gagcttatct gaggaaagtc attttatcag aaatttcatt tcatctagta     2880

gaggactttg atccatcctg tctcaccaat gacgacatga ggtttatttg tgaggctgtt     2940

gaaggttcaa cagaactgtc accattgtat tttacatcag ctgtcaaaga acaatgtggt     3000

ctggatgaga tggcaagaaa cctctgtaga aagttcttct cagagggtga ttggttctca     3060

tgtatgaaga tgatcttgtt acagatgaat gcaaatgcgt attcagggaa gtacagacac     3120

atgcagaggc agagcttaaa ttttaaattt gactgggaca aattggaaga agatgtaaga     3180

attagtgaaa gggaaagcaa ttctgaatct ctaagtaagg ccctttcatt gacaaaatgc     3240

atgagtgctg ctctaaagaa tctgtgtttt tactcagaag aatcaccaac atcatacact     3300

tcagttggcc ctgactctgg gagactaaaa tttgcattgt catacaaaga gcaggttggg     3360

ggaaatagag agctttacat tggggatttg aggacaaaaa tgttcacaag attggtagaa     3420

gattattttg aatccttttc tagtttcttt tcaggatctt gtttaaacaa tgacaaagag     3480

tttgaaaatg caatcttgtc aatgactatc aatgtgagag aagggttgtt aaactacagc     3540

atggatcaca gcaaatgggg accaatgatg tgcccattcc tattcttaat gctyctccaa     3600

aatctcaaac tgggtgatga tcagtacgtg cgttctggaa aagatcatgt tagcaccttg     3660

ttgacttggc atatgcataa acttgttgaa gtccctttcc ctgttgtgaa tgcaatgatg     3720

aaatcatatg ttaaatcaaa actcaagctt ctcaaagggt caggaacgac tgttacggag     3780

agaatcttta gagagtattt tgaaatgggg gtggtgccat ctcacatatc tagtctcatt     3840

gacatgggac aggggatcct acacaatgct tctgattttt acggtttaat tagtgaaagg     3900

tttatcaatt attgtattgg tgtcattttt ggagagaggc cagaagccta tacatcaagt     3960

gatgatcaga tcactttatt tgacaagaga ttgagtgact tagttgatag tgacccagaa     4020

gaagtccttg tcttgctgga attccactct cacttaagtg gtttgttgaa caagttcatc     4080

agtccaaaaa gtgtggttgg gcggtttgca gcggaattca aatccagatt ttatgtgtgg     4140

ggggaggagg tccctctcct cacgaaattt gtgtctgcgg cactacacaa tgttaagtgt     4200

aaagaaccgc atcaactttg tgagacaata gatacgattg ctgatcaagc tatagcaaat     4260

ggagttccag tttttttagt aaactgtatc cagaggagga cactggatct cttgaaatat     4320

gctaatttcc ctttagatcc attcttgtta aacactcaca ctgatgtaaa ggattggtta     4380

gatggttcta gaggttatag aatccaaaga ctcattgaag aattgtgtcc cagtgaaaca     4440

aagatcatga gaaaacttgt aagaagacta catcacaaac tcaagaacgg tgaatgtaac     4500

gaggaatttt ttctagacct cttcaacagg gaaaagaaag aggccatcct tcaattggga     4560

gagattcttg gtcttgagga tgatcttaat gagttggcaa gcatcaattg gttgaatctg     4620

aatgaaatgt tcccattgag gatggttctg agacaaaaag tggtttaccc atcagtratg     4680

acctttcaag aggaaaagat cccctcattg attaaaacac tccaaaataa gctttgtagt     4740

aagttcacaa gaggtgcaca gaagctgttg tcagaggcaa tcaacaaatc agcttttcag     4800

agttgtgtct catccggctt tataggtctc tgtaagactt taggaagtag gtgtgtgaga     4860

aataaaaaca gggaaaatat gtatatcaga aaggtgcttg aagatctgac catggatgaa     4920

catgtcacaa gggttcacaa acaagatggt gtgatgttgt acatttgcga caagcagaga     4980

cacccagagg ctcaccgtga ccacatcaac cttttgaggc cccttctctg ggactacatt     5040

tgcatctcat tgagcaactc ttttgagctg ggtgtttggg ttttagcaga acctgtgaaa     5100

ggaaagaacg agagtaattc ggctgttagg cacttaaatc catgtgatta tgtagcaaga     5160

aaacctgaga gttcgagact actagaggat aaagtgagtt tgaatcatgt aattcaatct     5220

gtgaggcgac tgtaccccaa aatctttgag gatcagttgc tcccattcat gtttgatgtg     5280

agctcaaaaa atatgagatg gagtcccagg attaaattcc ttgacctttg tgtgctgatt     5340

gacatcaact cagagtcttt gtcactcatt tctcatgttg tcaaatggaa gagggacgaa     5400

cattacactg tgctgttttc tgatctcgtc aactctcacc aacggtcaga ctcaagttta     5460

gttgatgaat ttgttgtcag cacaagggat gtctgcaaga actttttgaa gcaagtgtat     5520

ttcgaatcat ttgtacgaga gtttgttgca acagctagga ccttaggtaa cttttcatgg     5580

ttcccccata aggacatgat gccatctgaa gatggcgctg aagcactggg acccttccaa     5640

tcatttattt tgaaagtggt gaacaagaaa atagagaggc ccatgtttag gaatgacttg     5700

cagtttggtt ttggttggtt ctcttatcgt gtgggggatg ttgtgtgtaa tgccgctatg     5760

ttaattaagc agggtttgac agatccaaaa gcatttaaat ctttaagaga tttgtgggat     5820

tacatgctca gcagcacaga ggggatattg gagttctcaa tcacagtgga tttcacacac     5880

aaccagaaca acactgactg cttgaggaaa ttttcattga tctttgtggt taaatgccaa     5940

ttacagagtc caggtgtagc tgattactta tcgtgctctc atttcttcaa aggtgaggtt     6000

gacaggagat tattagatga gtgtctcaat ctgttgagga cagaccccat ctttaaagcg     6060

aatgatggag tctttgacat taggtctgaa gagtttgaag attacatgga agaccctttg     6120

acacttggtg attcactaga acttgaacta ataggttcta gaaggattct gaatgagatc     6180

aaatctactg actttgagag gatagggcct gagtgggaac ctgtgcctct gaccataagg     6240

aagggtgccc tctttgaggg gaggaacttt gttcagaata tctctgtgaa attggagaca     6300

aaggacatga grgtctttct ggcagagctc gagggctgtg gaaaaattgg tgatgtcctc     6360

ggcagcctcc tcctgcaccg attcagaact ggtgagcact tgatggagtc agaaataagt     6420

acagttcttc aggagctctg catggacaga tccgtcatgc tgacaccatt atcttttgtg     6480

ccagattggt tcaccttcag agattgtagg ctctgcttca gcaggtcaaa gaacactgtr     6540

atgtatgaga caactggggg caggttcaga ctcaagggga aatcctgtga cgattggctg     6600

gcggagcggg tggccgagga gatcgactag                                      6630


<210>  24
<211>  2209
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P42)

<400>  24

Met Asp Glu Thr Ile Ala Asp Leu Arg Glu Leu Cys Leu Asn Tyr Ile 
1               5                   10                  15      


Glu Gln Asp Glu Arg Leu Ser Arg Gln Lys Leu Asn Phe Leu Gly Gln 
            20                  25                  30          


Arg Glu Pro Arg Met Val Leu Ile Glu Gly Leu Lys Leu Leu Ser Arg 
        35                  40                  45              


Cys Ile Glu Ile Asp Ser Ala Asp Lys Ser Gly Cys Ile His Asn His 
    50                  55                  60                  


Asp Asp Lys Ser Val Glu Thr Ile Leu Ile Asp Ser Gly Ile Val Cys 
65                  70                  75                  80  


Pro Gly Leu Pro Leu Ile Ile Pro Asp Gly Tyr Lys Leu Ile Asp Asn 
                85                  90                  95      


Ser Leu Ile Leu Leu Glu Cys Phe Val Arg Ser Thr Pro Ala Ser Phe 
            100                 105                 110         


Glu Lys Lys Phe Ile Glu Asp Thr Asn Lys Leu Ala Cys Ile Lys Glu 
        115                 120                 125             


Asp Leu Ala Val Ala Gly Ile Thr Leu Val Pro Ile Val Asp Gly Arg 
    130                 135                 140                 


Cys Asp Tyr Asp Asn Ser Phe Met Pro Glu Trp Val Asn Phe Lys Phe 
145                 150                 155                 160 


Arg Asp Leu Leu Phe Lys Leu Leu Glu Tyr Ser Ser Gln Asp Glu Lys 
                165                 170                 175     


Val Phe Glu Glu Ser Glu Tyr Phe Arg Leu Cys Glu Ser Leu Lys Thr 
            180                 185                 190         


Thr Val Asp Lys Arg Ser Gly Met Asp Ser Met Lys Ile Leu Lys Asp 
        195                 200                 205             


Ala Arg Ser Phe His Asn Asp Glu Ile Met Lys Met Cys His Asp Gly 
    210                 215                 220                 


Val Asn Pro Asn Met Ser Cys Asp Asp Val Val Phe Gly Ile Asn Ser 
225                 230                 235                 240 


Phe Phe Gly Arg Phe Arg Arg Asp Leu Leu Asn Gly Lys Leu Lys Arg 
                245                 250                 255     


Asn Phe Gln Lys Val Ser Pro Gly Gly Leu Ile Lys Glu Phe Ser Glu 
            260                 265                 270         


Leu Tyr Glu Thr Leu Thr Asp Asn Asp Asp Ile Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Ala Val Glu Ser Cys Pro Leu Met Arg Phe Ile Thr Ala Glu Thr 
    290                 295                 300                 


His Gly His Glu Arg Gly Ser Asp Ala Asn Thr Glu Tyr Glu Arg Leu 
305                 310                 315                 320 


Leu Ser Met Leu Asn Lys Val Lys Ser Leu Lys Leu Leu Asn Thr Arg 
                325                 330                 335     


Arg Arg Gln Leu Leu Asn Leu Asp Val Leu Cys Leu Ser Ser Leu Ile 
            340                 345                 350         


Lys Gln Ser Ile Ser Lys Gly Leu Glu Asn Asp Lys His Trp Val Gly 
        355                 360                 365             


Cys Cys Tyr Ser Ser Val Asn Asp Arg Leu Val Ser Leu Gln Ser Thr 
    370                 375                 380                 


Lys Glu Glu Phe Met Arg Leu Leu Lys Asn Arg Arg Lys Ser Arg Val 
385                 390                 395                 400 


His Lys Lys Ala Ser Leu Asp Glu Leu Phe Arg Val Ser Ile Asn Glu 
                405                 410                 415     


Phe Ile Ala Lys Ile Gln Lys Cys Leu Ser Thr Val Gly Leu Ser Phe 
            420                 425                 430         


Glu His Tyr Gly Leu Ser Glu Cys Leu Val Gln Glu Cys His Ile Pro 
        435                 440                 445             


Phe Ala Glu Phe Glu Asn Phe Met Arg Ala Gly Thr His Pro Val Met 
    450                 455                 460                 


His Tyr Thr Lys Phe Glu Asp Tyr Thr Phe Gln Pro Asn Ile Glu Gln 
465                 470                 475                 480 


Leu Arg Gly Leu Gln Ser Leu Arg Lys Leu Ser Ser Val Cys Leu Ala 
                485                 490                 495     


Leu Thr Asn Ser Met Lys Thr Ser Ser Val Ala Arg Leu Arg Gln Asn 
            500                 505                 510         


Gln Leu Gly Ser Val Arg Tyr Gln Val Val Glu Cys Lys Glu Val Phe 
        515                 520                 525             


Cys Gln Ile Ile Lys Leu Asp Ser Glu Glu Tyr His Leu Leu Tyr Gln 
    530                 535                 540                 


Lys Thr Gly Glu Ser Ser Arg Cys Tyr Ser Ile Gln Gly Pro Asp Gly 
545                 550                 555                 560 


His Leu Ile Ser Phe Tyr Ala Asp Pro Lys Arg Phe Phe Leu Pro Ile 
                565                 570                 575     


Phe Ser Asp Glu Val Leu His Asn Met Ile Asp Thr Met Ile Ser Trp 
            580                 585                 590         


Ile Arg Ser Cys Pro Asp Leu Lys Asp Ser Leu Ile Asp Ile Glu Thr 
        595                 600                 605             


Ala Leu Arg Thr Leu Ile Leu Leu Met Leu Thr Asn Pro Thr Lys Arg 
    610                 615                 620                 


Asn Gln Lys Gln Val Gln Asn Ile Arg Tyr Leu Val Met Ala Ile Val 
625                 630                 635                 640 


Ser Asp Phe Ser Ser Thr Ser Leu Met Asp Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Ile Thr Pro Ala Glu Lys Val Val Tyr Arg Leu Leu Arg Phe Leu Ile 
            660                 665                 670         


Arg Thr Ile Phe Gly Thr Gly Glu Lys Val Leu Leu Ser Ala Lys Phe 
        675                 680                 685             


Lys Phe Met Leu Asn Val Ser Tyr Leu Cys His Leu Ile Thr Lys Glu 
    690                 695                 700                 


Thr Pro Asp Arg Leu Thr Asp Gln Ile Lys Cys Phe Glu Lys Phe Phe 
705                 710                 715                 720 


Glu Pro Lys Ser Glu Phe Gly Phe Phe Val Asn Pro Lys Glu Thr Ile 
                725                 730                 735     


Thr Pro Glu Glu Glu Cys Val Phe Tyr Glu Gln Met Lys Lys Phe Thr 
            740                 745                 750         


Gly Lys Asp Ile Asp Cys Gln His Ser Thr Pro Gly Val Asn Leu Glu 
        755                 760                 765             


Ile Phe Ser Met Met Val Ser Ser Phe Asn Asn Gly Thr Leu Ile Leu 
    770                 775                 780                 


Lys Gly Glu Lys Arg Leu Asn Asn Leu Asp Pro Met Thr Asn Ser Gly 
785                 790                 795                 800 


Cys Ala Thr Ala Leu Asp Leu Ala Ser Asn Lys Ser Val Val Val Asn 
                805                 810                 815     


Lys His Leu Asn Gly Glu Arg Leu Leu Glu Tyr Asp Phe Asn Lys Leu 
            820                 825                 830         


Leu Val Ser Ala Val Ser Gln Ile Thr Glu Gly Phe Met Arg Lys Gln 
        835                 840                 845             


Lys Tyr Lys Leu Arg His Ser Asp Tyr Glu Tyr Lys Val Ser Lys Leu 
    850                 855                 860                 


Val Ser Arg Leu Val Ile Gly Ser Arg Lys Thr Glu Val Asp Lys Leu 
865                 870                 875                 880 


Glu Asp Asp Pro Val Asp Val Cys Phe Glu Gly Glu Glu Glu Thr Ser 
                885                 890                 895     


Phe Phe Arg Ser Leu Glu Asp Lys Val Ser Ser Thr Ile Thr Arg Tyr 
            900                 905                 910         


Asn Arg Gly Thr Arg Leu Asn Glu Gly Gln Gly Glu Gly Glu Phe Lys 
        915                 920                 925             


Asn Thr Lys Gly Leu His His Leu Gln Ile Ile Leu Ser Gly Lys Arg 
    930                 935                 940                 


Ala Tyr Leu Arg Lys Val Ile Leu Ser Glu Ile Ser Phe His Leu Val 
945                 950                 955                 960 


Glu Asp Phe Asp Pro Ser Cys Leu Thr Asn Asp Asp Met Arg Phe Ile 
                965                 970                 975     


Cys Glu Ala Val Glu Gly Ser Thr Glu Leu Ser Pro Leu Tyr Phe Thr 
            980                 985                 990         


Ser Ala Val Lys Glu Gln Cys Gly  Leu Asp Glu Met Ala  Arg Asn Leu 
        995                 1000                 1005             


Cys Arg  Lys Phe Phe Ser Glu  Gly Asp Trp Phe Ser  Cys Met Lys 
    1010                 1015                 1020             


Met Ile  Leu Leu Gln Met Asn  Ala Asn Ala Tyr Ser  Gly Lys Tyr 
    1025                 1030                 1035             


Arg His  Met Gln Arg Gln Ser  Leu Asn Phe Lys Phe  Asp Trp Asp 
    1040                 1045                 1050             


Lys Leu  Glu Glu Asp Val Arg  Ile Ser Glu Arg Glu  Ser Asn Ser 
    1055                 1060                 1065             


Glu Ser  Leu Ser Lys Ala Leu  Ser Leu Thr Lys Cys  Met Ser Ala 
    1070                 1075                 1080             


Ala Leu  Lys Asn Leu Cys Phe  Tyr Ser Glu Glu Ser  Pro Thr Ser 
    1085                 1090                 1095             


Tyr Thr  Ser Val Gly Pro Asp  Ser Gly Arg Leu Lys  Phe Ala Leu 
    1100                 1105                 1110             


Ser Tyr  Lys Glu Gln Val Gly  Gly Asn Arg Glu Leu  Tyr Ile Gly 
    1115                 1120                 1125             


Asp Leu  Arg Thr Lys Met Phe  Thr Arg Leu Val Glu  Asp Tyr Phe 
    1130                 1135                 1140             


Glu Ser  Phe Ser Ser Phe Phe  Ser Gly Ser Cys Leu  Asn Asn Asp 
    1145                 1150                 1155             


Lys Glu  Phe Glu Asn Ala Ile  Leu Ser Met Thr Ile  Asn Val Arg 
    1160                 1165                 1170             


Glu Gly  Leu Leu Asn Tyr Ser  Met Asp His Ser Lys  Trp Gly Pro 
    1175                 1180                 1185             


Met Met  Cys Pro Phe Leu Phe  Leu Met Leu Leu Gln  Asn Leu Lys 
    1190                 1195                 1200             


Leu Gly  Asp Asp Gln Tyr Val  Arg Ser Gly Lys Asp  His Val Ser 
    1205                 1210                 1215             


Thr Leu  Leu Thr Trp His Met  His Lys Leu Val Glu  Val Pro Phe 
    1220                 1225                 1230             


Pro Val  Val Asn Ala Met Met  Lys Ser Tyr Val Lys  Ser Lys Leu 
    1235                 1240                 1245             


Lys Leu  Leu Lys Gly Ser Gly  Thr Thr Val Thr Glu  Arg Ile Phe 
    1250                 1255                 1260             


Arg Glu  Tyr Phe Glu Met Gly  Val Val Pro Ser His  Ile Ser Ser 
    1265                 1270                 1275             


Leu Ile  Asp Met Gly Gln Gly  Ile Leu His Asn Ala  Ser Asp Phe 
    1280                 1285                 1290             


Tyr Gly  Leu Ile Ser Glu Arg  Phe Ile Asn Tyr Cys  Ile Gly Val 
    1295                 1300                 1305             


Ile Phe  Gly Glu Arg Pro Glu  Ala Tyr Thr Ser Ser  Asp Asp Gln 
    1310                 1315                 1320             


Ile Thr  Leu Phe Asp Lys Arg  Leu Ser Asp Leu Val  Asp Ser Asp 
    1325                 1330                 1335             


Pro Glu  Glu Val Leu Val Leu  Leu Glu Phe His Ser  His Leu Ser 
    1340                 1345                 1350             


Gly Leu  Leu Asn Lys Phe Ile  Ser Pro Lys Ser Val  Val Gly Arg 
    1355                 1360                 1365             


Phe Ala  Ala Glu Phe Lys Ser  Arg Phe Tyr Val Trp  Gly Glu Glu 
    1370                 1375                 1380             


Val Pro  Leu Leu Thr Lys Phe  Val Ser Ala Ala Leu  His Asn Val 
    1385                 1390                 1395             


Lys Cys  Lys Glu Pro His Gln  Leu Cys Glu Thr Ile  Asp Thr Ile 
    1400                 1405                 1410             


Ala Asp  Gln Ala Ile Ala Asn  Gly Val Pro Val Phe  Leu Val Asn 
    1415                 1420                 1425             


Cys Ile  Gln Arg Arg Thr Leu  Asp Leu Leu Lys Tyr  Ala Asn Phe 
    1430                 1435                 1440             


Pro Leu  Asp Pro Phe Leu Leu  Asn Thr His Thr Asp  Val Lys Asp 
    1445                 1450                 1455             


Trp Leu  Asp Gly Ser Arg Gly  Tyr Arg Ile Gln Arg  Leu Ile Glu 
    1460                 1465                 1470             


Glu Leu  Cys Pro Ser Glu Thr  Lys Ile Met Arg Lys  Leu Val Arg 
    1475                 1480                 1485             


Arg Leu  His His Lys Leu Lys  Asn Gly Glu Cys Asn  Glu Glu Phe 
    1490                 1495                 1500             


Phe Leu  Asp Leu Phe Asn Arg  Glu Lys Lys Glu Ala  Ile Leu Gln 
    1505                 1510                 1515             


Leu Gly  Glu Ile Leu Gly Leu  Glu Asp Asp Leu Asn  Glu Leu Ala 
    1520                 1525                 1530             


Ser Ile  Asn Trp Leu Asn Leu  Asn Glu Met Phe Pro  Leu Arg Met 
    1535                 1540                 1545             


Val Leu  Arg Gln Lys Val Val  Tyr Pro Ser Val Met  Thr Phe Gln 
    1550                 1555                 1560             


Glu Glu  Lys Ile Pro Ser Leu  Ile Lys Thr Leu Gln  Asn Lys Leu 
    1565                 1570                 1575             


Cys Ser  Lys Phe Thr Arg Gly  Ala Gln Lys Leu Leu  Ser Glu Ala 
    1580                 1585                 1590             


Ile Asn  Lys Ser Ala Phe Gln  Ser Cys Val Ser Ser  Gly Phe Ile 
    1595                 1600                 1605             


Gly Leu  Cys Lys Thr Leu Gly  Ser Arg Cys Val Arg  Asn Lys Asn 
    1610                 1615                 1620             


Arg Glu  Asn Met Tyr Ile Arg  Lys Val Leu Glu Asp  Leu Thr Met 
    1625                 1630                 1635             


Asp Glu  His Val Thr Arg Val  His Lys Gln Asp Gly  Val Met Leu 
    1640                 1645                 1650             


Tyr Ile  Cys Asp Lys Gln Arg  His Pro Glu Ala His  Arg Asp His 
    1655                 1660                 1665             


Ile Asn  Leu Leu Arg Pro Leu  Leu Trp Asp Tyr Ile  Cys Ile Ser 
    1670                 1675                 1680             


Leu Ser  Asn Ser Phe Glu Leu  Gly Val Trp Val Leu  Ala Glu Pro 
    1685                 1690                 1695             


Val Lys  Gly Lys Asn Glu Ser  Asn Ser Ala Val Arg  His Leu Asn 
    1700                 1705                 1710             


Pro Cys  Asp Tyr Val Ala Arg  Lys Pro Glu Ser Ser  Arg Leu Leu 
    1715                 1720                 1725             


Glu Asp  Lys Val Ser Leu Asn  His Val Ile Gln Ser  Val Arg Arg 
    1730                 1735                 1740             


Leu Tyr  Pro Lys Ile Phe Glu  Asp Gln Leu Leu Pro  Phe Met Phe 
    1745                 1750                 1755             


Asp Val  Ser Ser Lys Asn Met  Arg Trp Ser Pro Arg  Ile Lys Phe 
    1760                 1765                 1770             


Leu Asp  Leu Cys Val Leu Ile  Asp Ile Asn Ser Glu  Ser Leu Ser 
    1775                 1780                 1785             


Leu Ile  Ser His Val Val Lys  Trp Lys Arg Asp Glu  His Tyr Thr 
    1790                 1795                 1800             


Val Leu  Phe Ser Asp Leu Val  Asn Ser His Gln Arg  Ser Asp Ser 
    1805                 1810                 1815             


Ser Leu  Val Asp Glu Phe Val  Val Ser Thr Arg Asp  Val Cys Lys 
    1820                 1825                 1830             


Asn Phe  Leu Lys Gln Val Tyr  Phe Glu Ser Phe Val  Arg Glu Phe 
    1835                 1840                 1845             


Val Ala  Thr Ala Arg Thr Leu  Gly Asn Phe Ser Trp  Phe Pro His 
    1850                 1855                 1860             


Lys Asp  Met Met Pro Ser Glu  Asp Gly Ala Glu Ala  Leu Gly Pro 
    1865                 1870                 1875             


Phe Gln  Ser Phe Ile Leu Lys  Val Val Asn Lys Lys  Ile Glu Arg 
    1880                 1885                 1890             


Pro Met  Phe Arg Asn Asp Leu  Gln Phe Gly Phe Gly  Trp Phe Ser 
    1895                 1900                 1905             


Tyr Arg  Val Gly Asp Val Val  Cys Asn Ala Ala Met  Leu Ile Lys 
    1910                 1915                 1920             


Gln Gly  Leu Thr Asp Pro Lys  Ala Phe Lys Ser Leu  Arg Asp Leu 
    1925                 1930                 1935             


Trp Asp  Tyr Met Leu Ser Ser  Thr Glu Gly Ile Leu  Glu Phe Ser 
    1940                 1945                 1950             


Ile Thr  Val Asp Phe Thr His  Asn Gln Asn Asn Thr  Asp Cys Leu 
    1955                 1960                 1965             


Arg Lys  Phe Ser Leu Ile Phe  Val Val Lys Cys Gln  Leu Gln Ser 
    1970                 1975                 1980             


Pro Gly  Val Ala Asp Tyr Leu  Ser Cys Ser His Phe  Phe Lys Gly 
    1985                 1990                 1995             


Glu Val  Asp Arg Arg Leu Leu  Asp Glu Cys Leu Asn  Leu Leu Arg 
    2000                 2005                 2010             


Thr Asp  Pro Ile Phe Lys Ala  Asn Asp Gly Val Phe  Asp Ile Arg 
    2015                 2020                 2025             


Ser Glu  Glu Phe Glu Asp Tyr  Met Glu Asp Pro Leu  Thr Leu Gly 
    2030                 2035                 2040             


Asp Ser  Leu Glu Leu Glu Leu  Ile Gly Ser Arg Arg  Ile Leu Asn 
    2045                 2050                 2055             


Glu Ile  Lys Ser Thr Asp Phe  Glu Arg Ile Gly Pro  Glu Trp Glu 
    2060                 2065                 2070             


Pro Val  Pro Leu Thr Ile Arg  Lys Gly Ala Leu Phe  Glu Gly Arg 
    2075                 2080                 2085             


Asn Phe  Val Gln Asn Ile Ser  Val Lys Leu Glu Thr  Lys Asp Met 
    2090                 2095                 2100             


Arg Val  Phe Leu Ala Glu Leu  Glu Gly Cys Gly Lys  Ile Gly Asp 
    2105                 2110                 2115             


Val Leu  Gly Ser Leu Leu Leu  His Arg Phe Arg Thr  Gly Glu His 
    2120                 2125                 2130             


Leu Met  Glu Ser Glu Ile Ser  Thr Val Leu Gln Glu  Leu Cys Met 
    2135                 2140                 2145             


Asp Arg  Ser Val Met Leu Thr  Pro Leu Ser Phe Val  Pro Asp Trp 
    2150                 2155                 2160             


Phe Thr  Phe Arg Asp Cys Arg  Leu Cys Phe Ser Arg  Ser Lys Asn 
    2165                 2170                 2175             


Thr Val  Met Tyr Glu Thr Thr  Gly Gly Arg Phe Arg  Leu Lys Gly 
    2180                 2185                 2190             


Lys Ser  Cys Asp Asp Trp Leu  Ala Glu Arg Val Ala  Glu Glu Ile 
    2195                 2200                 2205             


Asp 
    


<210>  25
<211>  1497
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52)

<400>  25
atgggtcaga ttgtgacaat gtttgaggct ttgcctcaca tcattgatga ggtcatcaac       60

attgtcatta ttgtgctcat tataatcacg agcatcaaag ctgtgtacaa tttcgccacc      120

tgtgggatat tagcactggt cagcttcctt tttttggctg gtaggtcctg tggcatgtac      180

ggccttaatg gtcccgacat ctataaaggg gtttaccagt tcaaatcagt ggagtttgat      240

atgtctcact taaatctgac gatgcccaat gcgtgctcag ccaacaactc tcatcactac      300

atcagtatgg gaagctctgg actggagcta actttcacta acgactccat ccttaatcac      360

aatttttgca acttaacctc cgctttcaac aaaaagactt ttgaccatac actcatgagt      420

atagtctcga gtctgcacct cagtattaga gggaattcca accacaaagc agtgtcttgt      480

gattttaaca atggcatcac cattcaatac aacttgtcat tttcggaccc acagagcgct      540

atgagccagt gttggacttt cagaggtaga gtcttggaca tgtttagaac tgcctttgga      600

ggaaaataca tgagaagtgg ctggggctgg gcaggttcag atggcaagac cacttggtgc      660

agccaaacaa gctatcagta cctaatcata caaaacagga cttgggaaaa ccactgtaga      720

tatgcaggcc cttttgggat gtctagaatc ctctttgctc aggaaaagac aaagtttctc      780

actaggagac ttgcaggcac attcacctgg accctgtcag actcctcagg agtagaaaat      840

ccaggtggtt attgcctgac caaatggatg atccttgctg cagagctcaa atgttttggg      900

aatacagctg ttgcaaaatg taatgtcaat catgatgaag agttctgtga catgctacga      960

ctaattgatt acaacaaggc cgccctgagt aagttcaagc aagatgtaga gtctgccttg     1020

catgtattca aaacaacagt aaattctctg atttccgatc agctgttgat gaggaatcat     1080

ctaagagatc taatgggggt accatactgt aattactcaa agttctggta tctggaacat     1140

gctaagactg gtgagactag tgtacccaag tgctggcttg tcactaatgg ctcctacttg     1200

aatgagaccc actttagtga tcaaatcgaa caagaagcag ataacatgat cacagagatg     1260

ttgaggaagg actacataaa aagacaaggg agtactcctt tagccttaat ggatcttttg     1320

atgttttcaa catcagcata tctaatcagc atctttctgc atcttgtgaa gataccaaca     1380

catagacaca taaagggcgg ttcatgtcca aagccacacc gcttgaccaa caaggggatc     1440

tgtagttgtg gtgcattcaa ggtgcctggt gtaaaaacta tctggaaaag acgctga        1497


<210>  26
<211>  498
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52)

<400>  26

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Asn Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Ser Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Leu Asn His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn His Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Ser Phe Ser Asp 
                165                 170                 175     


Pro Gln Ser Ala Met Ser Gln Cys Trp Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Ala Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Arg 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Phe Ala Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Gln Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Val Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Ile Trp Lys 
                485                 490                 495     


Arg Arg 
        


<210>  27
<211>  1677
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52)

<400>  27
atgtctttgt ccaaagaagt caaaagcttt cagtggacac aggcgttgag gagggagttg       60

cagagtttta catcagatgt aaaggctgcc gtcatcaagg acgcaaccag tcttctaaat      120

gggttggact tttctgaagt cagcaacgtt cagaggatca tgagaaagga aaggagggat      180

gataaagact tgcagagact caggagtctt aaccagactg tgcattctct tgttgatctg      240

aagtctacat caaagaaaaa tgttctgaaa gtgggaagac ttagtgcaga ggaattgatg      300

acccttgcag ctgatcttga gaagctgaag gccaaaatta tgagaactga gaggcctcaa      360

gcttctggag tctacatggg aaatttgaca gcacaacaac ttgatcaaag atcccaaata      420

ctgcaaatgg ttgggatgag aagacctcag cagggtgcaa gtggtgtagt aagggtttgg      480

gatgtgaagg actcatcact tctgaacaat cagttcggca caatgccaag cctgacaatg      540

gcttgcatgg caaaacagtc acagacccca ctcaatgatg ttgtgcaggc actcacagac      600

cttggcttac tttacacagt caaatacccg aatctcagtg atcttgaaag gctaaaggat      660

aaacacccag ttctgggggt cattactgaa cagcaatcta gtatcaatat ctctggttat      720

aatttcagtc ttggtgcagc tgtgaaagcg ggggcagctc tgctagatgg agggaacatg      780

ctggaatcta tcttgatcaa accgagcaac agtgaggatc tcctaaaagc agtcctcggg      840

gccaagaaga aactcaacat gtttgtctca gatcaagttg gagatagaaa tccctatgaa      900

aacatccttt ataaagtctg tctttcaggt gaaggatggc catacatagc ctgtagaacg      960

tcagttgtgg ggagagcatg ggagaacaca acaattgatc tcacaaatga aaaacttgtt     1020

gccaactcat ctaggccagt gcctggagca gcaggcccac ctcaggtggg cttgagttac     1080

agtcagacaa tgctgttgaa agacttgatg ggagggattg atcccaatgc tcccacatgg     1140

attgacattg agggcaggtt caatgatcca gtggagatag caatattcca accacaaaat     1200

gggcaattca tacattttta cagggaacct acggaccaga agcaattcaa gcaggactca     1260

aagtattcac acggcatgga tcttgctgat ctcttcaatg cacagcctgg gctgacctca     1320

tcagttatag gtgctctccc acaagggatg gttttgagct gtcaaggttc tgatgacatc     1380

agaaagcttc tggactcaca aaayagaagg gacataaaac tcattgatgt tgagatgacc     1440

aaggaggcct caagagaata tgaagataaa gtgtgggaca aatatggctg gctatgcaaa     1500

atgcacactg gggtagtgag agacaaaaag aagaaagaga tcaccccaca ctgtgcactc     1560

atggactgca tcatttttga gagtgcttcc aaggcaagac tccctgatct aaaaaccgtt     1620

cacaacatcc tgccacatga tttaatcttc agaggaccca atgttgtgac actctaa        1677


<210>  28
<211>  558
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52)

<400>  28

Met Ser Leu Ser Lys Glu Val Lys Ser Phe Gln Trp Thr Gln Ala Leu 
1               5                   10                  15      


Arg Arg Glu Leu Gln Ser Phe Thr Ser Asp Val Lys Ala Ala Val Ile 
            20                  25                  30          


Lys Asp Ala Thr Ser Leu Leu Asn Gly Leu Asp Phe Ser Glu Val Ser 
        35                  40                  45              


Asn Val Gln Arg Ile Met Arg Lys Glu Arg Arg Asp Asp Lys Asp Leu 
    50                  55                  60                  


Gln Arg Leu Arg Ser Leu Asn Gln Thr Val His Ser Leu Val Asp Leu 
65                  70                  75                  80  


Lys Ser Thr Ser Lys Lys Asn Val Leu Lys Val Gly Arg Leu Ser Ala 
                85                  90                  95      


Glu Glu Leu Met Thr Leu Ala Ala Asp Leu Glu Lys Leu Lys Ala Lys 
            100                 105                 110         


Ile Met Arg Thr Glu Arg Pro Gln Ala Ser Gly Val Tyr Met Gly Asn 
        115                 120                 125             


Leu Thr Ala Gln Gln Leu Asp Gln Arg Ser Gln Ile Leu Gln Met Val 
    130                 135                 140                 


Gly Met Arg Arg Pro Gln Gln Gly Ala Ser Gly Val Val Arg Val Trp 
145                 150                 155                 160 


Asp Val Lys Asp Ser Ser Leu Leu Asn Asn Gln Phe Gly Thr Met Pro 
                165                 170                 175     


Ser Leu Thr Met Ala Cys Met Ala Lys Gln Ser Gln Thr Pro Leu Asn 
            180                 185                 190         


Asp Val Val Gln Ala Leu Thr Asp Leu Gly Leu Leu Tyr Thr Val Lys 
        195                 200                 205             


Tyr Pro Asn Leu Ser Asp Leu Glu Arg Leu Lys Asp Lys His Pro Val 
    210                 215                 220                 


Leu Gly Val Ile Thr Glu Gln Gln Ser Ser Ile Asn Ile Ser Gly Tyr 
225                 230                 235                 240 


Asn Phe Ser Leu Gly Ala Ala Val Lys Ala Gly Ala Ala Leu Leu Asp 
                245                 250                 255     


Gly Gly Asn Met Leu Glu Ser Ile Leu Ile Lys Pro Ser Asn Ser Glu 
            260                 265                 270         


Asp Leu Leu Lys Ala Val Leu Gly Ala Lys Lys Lys Leu Asn Met Phe 
        275                 280                 285             


Val Ser Asp Gln Val Gly Asp Arg Asn Pro Tyr Glu Asn Ile Leu Tyr 
    290                 295                 300                 


Lys Val Cys Leu Ser Gly Glu Gly Trp Pro Tyr Ile Ala Cys Arg Thr 
305                 310                 315                 320 


Ser Val Val Gly Arg Ala Trp Glu Asn Thr Thr Ile Asp Leu Thr Asn 
                325                 330                 335     


Glu Lys Leu Val Ala Asn Ser Ser Arg Pro Val Pro Gly Ala Ala Gly 
            340                 345                 350         


Pro Pro Gln Val Gly Leu Ser Tyr Ser Gln Thr Met Leu Leu Lys Asp 
        355                 360                 365             


Leu Met Gly Gly Ile Asp Pro Asn Ala Pro Thr Trp Ile Asp Ile Glu 
    370                 375                 380                 


Gly Arg Phe Asn Asp Pro Val Glu Ile Ala Ile Phe Gln Pro Gln Asn 
385                 390                 395                 400 


Gly Gln Phe Ile His Phe Tyr Arg Glu Pro Thr Asp Gln Lys Gln Phe 
                405                 410                 415     


Lys Gln Asp Ser Lys Tyr Ser His Gly Met Asp Leu Ala Asp Leu Phe 
            420                 425                 430         


Asn Ala Gln Pro Gly Leu Thr Ser Ser Val Ile Gly Ala Leu Pro Gln 
        435                 440                 445             


Gly Met Val Leu Ser Cys Gln Gly Ser Asp Asp Ile Arg Lys Leu Leu 
    450                 455                 460                 


Asp Ser Gln Asn Arg Arg Asp Ile Lys Leu Ile Asp Val Glu Met Thr 
465                 470                 475                 480 


Lys Glu Ala Ser Arg Glu Tyr Glu Asp Lys Val Trp Asp Lys Tyr Gly 
                485                 490                 495     


Trp Leu Cys Lys Met His Thr Gly Val Val Arg Asp Lys Lys Lys Lys 
            500                 505                 510         


Glu Ile Thr Pro His Cys Ala Leu Met Asp Cys Ile Ile Phe Glu Ser 
        515                 520                 525             


Ala Ser Lys Ala Arg Leu Pro Asp Leu Lys Thr Val His Asn Ile Leu 
    530                 535                 540                 


Pro His Asp Leu Ile Phe Arg Gly Pro Asn Val Val Thr Leu 
545                 550                 555             


<210>  29
<211>  273
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52)

<400>  29
atgggccaag gcaagtccaa agaagaaagg gacaccagca atacaggcag agcagagctt       60

ttgccagaca ccacctatct tggtcctcta aattgtaaat catgttggca gaaatttgac      120

agcttggtta gatgccatga ccactatctt tgcagacact gtctgaatct cctgctgtca      180

gtttccgaca gatgtcctct ctgtaagtat ccactgccaa ccaaactgaa ggtgtcaaca      240

gtcccaagct ccccacctcc ctatgaggag tga                                   273


<210>  30
<211>  90
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52)

<400>  30

Met Gly Gln Gly Lys Ser Lys Glu Glu Arg Asp Thr Ser Asn Thr Gly 
1               5                   10                  15      


Arg Ala Glu Leu Leu Pro Asp Thr Thr Tyr Leu Gly Pro Leu Asn Cys 
            20                  25                  30          


Lys Ser Cys Trp Gln Lys Phe Asp Ser Leu Val Arg Cys His Asp His 
        35                  40                  45              


Tyr Leu Cys Arg His Cys Leu Asn Leu Leu Leu Ser Val Ser Asp Arg 
    50                  55                  60                  


Cys Pro Leu Cys Lys Tyr Pro Leu Pro Thr Lys Leu Lys Val Ser Thr 
65                  70                  75                  80  


Val Pro Ser Ser Pro Pro Pro Tyr Glu Glu 
                85                  90  


<210>  31
<211>  6630
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52)

<400>  31
atggatgaaa ctattgcaga tttgagagag ttgtgtctaa attacataga acaggacgag       60

aggctgtcaa ggcaaaaact caacttcctg ggacaaagag aacccagaat ggtgctaatt      120

gagggactca aattgttatc acgctgtata gagatagaca gtgcagacaa aagtggttgc      180

atacacaacc acgatgacaa atctgttgaa acaatcctaa tagactctgg gattgtgtgt      240

ccaggactgc cactcatcat ccctgatggt tataagttga ttgacaattc ccttattctt      300

cttgaatgtt ttgttagaag cacaccagct agttttgaaa agaagttcat tgaggacacc      360

aacaaactag catgcatcaa agaagatctt gctgttgcag gcatcacact ggttccaata      420

gtggatggtc gttgtgatta tgataacagt ttcatgccag aatgggtgaa ttttaagttc      480

agagacctcc tatttaaact cctggagtat tctagtcaag atgagaaagt ttttgaggag      540

tctgaatact tcaggctctg tgagtctctt aagaccactg ttgacaaacg ttccggcatg      600

gactcaatga aaattttgaa agacgcaaga tcatttcata acgatgagat tatgaaaatg      660

tgccacgatg gtgtcaaccc caacatgagt tgcgatgatg tggtctttgg cataaattcc      720

ttttttggca ggtttaggag ggacctgtta aatgggaaac tcaaaaggaa tttccaaaag      780

gtcagccctg ggggcttaat caaggaattc tctgaacttt atgaaaccct tactgataat      840

gatgacatat taatgttgag caaagaggca gttgaatcct gccccttaat gaggttcatt      900

acagcagaga cccatgggca tgagagagga agcgatgcta acactgagta tgaaaggcta      960

ctctctatgt tgaacaaggt gaaaagttta aaattattaa acactagaag gagacagctg     1020

ctgaacttag atgtcttatg tctttcttca cttattaagc agtcaatttc caaagggttg     1080

gaaaatgata aacattgggt tggttgttgc tacagtagtg tgaatgatag gcttgtgagc     1140

cttcaaagta ccaaagaaga attcatgaga cttttgaaga acagaagaaa atcaagagtg     1200

cacaaaaagg catctcttga tgagcttttt agggtatcca taaatgagtt catagcaaaa     1260

atccagaaat gcctatcaac agtgggactt agttttgagc attacggact atcagaatgc     1320

ctcgtgcaag aatgccatat accatttgct gaatttgaga actttatgag agccgggact     1380

catcctgtaa tgcattacac aaaatttgaa gattacactt tccagcctaa catagagcaa     1440

ttgaggggtt tacagagttt gagaaaactg tcatctgttt gtttggctct aacaaacagc     1500

atgaaaacaa gctcagttgc aaggttgaga cagaaccaac tggggtctgt gagatatcaa     1560

gtggtggagt gcaaagaggt gttttgccag ataataaaac tggattccga agagtatcat     1620

ctactatatc agaaaactgg agaatcatcg aggtgttatt ccatacaagg tccggatggt     1680

cacttgattt ccttttacgc agatccaaaa aggttctttt taccaatttt ttcagatgag     1740

gtgttgcaca acatgataga cacaatgatt tcatggatta ggtcatgccc tgacttaaaa     1800

gattctctta ttgacattga gactgcacta aggacattga tcctactgat gctcaccaac     1860

ccaacaaaga gaaatcaaaa gcaggttcaa aatattaggt atttagtgat ggccatcgtc     1920

tcagactttt catcgacctc attaatggat aagttgaagg aggatctaat cacacctgcc     1980

gagaaagtgg tgtacaggct gcttcggttt ttgattagga caatttttgg tactggtgaa     2040

aaggtgttat tgagtgcaaa attcaagttt atgttgaatg trtcatacct gtgtcatttg     2100

atcacaaagg agacccctga tagattgaca gatcagataa aatgttttga aaagttcttt     2160

gagcccaaga gtgagtttgg tttctttgtc aaccctaagg aaacaatcac acccgaagag     2220

gaatgtgttt tttatgaaca aatgaagaag ttcaccggta aagatattga ttgtcagcat     2280

tcaacccctg gtgttaattt agagatcttt agcatgatgg tatcttcatt caacaatggc     2340

accttaattc taaaagggga gaaaaggctc aacaatctgg accccatgac caactctgga     2400

tgtgcgacag cattagatct cgcaagcaac aaaagtgtgg ttgtcaataa acatctgaat     2460

ggagaacggc ttttggagta tgattttaac aaattgcttg ttagtgctgt gagccaaatt     2520

acagagggct tcatgaggaa acaaaagtat aagctgagac actcagatta cgaatataag     2580

gtctcaaagc ttgtctctag attagtcatc ggttccagga aaacagaagt agacaaattg     2640

gaagatgatc cggtagatgt gtgtttcgag ggggaggagg agacaagttt tttcaggagt     2700

ttagaagata aggtcagctc cacaataaca cggtataata gaggcactag gcttaatgaa     2760

gggcaagggg agggagaatt caagaacaca aaaggactac accaccttca gattattttg     2820

tcaggtaaaa gagcttatct gaggaaagtc attttatcag aaatttcatt tcatctagta     2880

gaggactttg atccatcctg tctcaccaat gacgacatga ggtttatttg tgaggctgtt     2940

gaaggttcaa cagaactgtc accattgtat tttacatcag ctgtcaaaga acaatgtggt     3000

ctggatgaga tggcaagaaa cctctgtaga aagttcttct cagagggtga ttggttctca     3060

tgtatgaaga tgatcttgtt acagatgaat gcaaatgcgt attcagggaa gtacagacac     3120

atgcagaggc agagcttaaa ttttaaattt gactgggaca aattggaaga agatgtaaga     3180

attagtgaaa gggaaagcaa ttctgaatct ctaagtaagg ccctttcatt gacaaaatgc     3240

atgagtgctg ctctaaagaa tctgtgtttt tactcagaag aatcaccaac atcatacact     3300

tcagttggcc ctgactctgg gagactaaaa tttgcattgt catacaaaga gcaggttggg     3360

ggaaatagag agctttacat tggggatttg aggacaaaaa tgttcacaag attggtagaa     3420

gattattttg aatccttttc tagtttcttt tcaggatctt gtttaaacaa tgacaaagag     3480

tttgaaaatg caatcttgtc aatgactatc aatgtgagag aagggttgtt aaactacagc     3540

atggatcaca gcaaatgggg accaatgatg tgcccattcc tattcttaat gcttctccaa     3600

aatctcaaac tgggtgatga tcagtacgtg cgttctggaa aagatcatgt tagcaccttg     3660

ttgacttggc atatgcataa acttgttgaa gtccctttcc ctgttgtgaa tgcaatgatg     3720

aaatcatatg ttaaatcaaa actcaagctt ctcaaagggt caggaacgac tgttacggag     3780

agaatcttta gagagtattt tgaaatgggg gtggtgccat ctcacatatc tagtctcatt     3840

gacatgggac aggggatcct acacaatgct tctgattttt acggtttaat tagtgaaagg     3900

tttatcaatt attgtattgg tgtcattttt ggagagaggc cagaagccta tacatcaagt     3960

gatgatcaga tcactttatt tgacaagaga ttgagtgact tagttgatag tgacccagaa     4020

gaagtccttg tcttgctgga attccactct cacttaagtg gtttgttgaa caagttcatc     4080

agtccaaaaa gtgtggttgg gcggtttgca gcggaattca aatccagatt ttatgtgtgg     4140

ggggaggagg tccctctcct cacgaaattt gtgtctgcgg cactacacaa tgttaagtgt     4200

aaagaaccgc atcaactttg tgagacaata gatacgattg ctgatcaagc tatagcaaat     4260

ggagttccag tttttttagt aaactgtatc cagaggagga cactggatct cttgaaatat     4320

gctaatttcc ctttagatcc attcttgtta aacactcaca ctgatgtaaa ggattggtta     4380

gatggttcta gaggttatag aatccaaaga ctcattgaag aattgtgtcc cagtgaaaca     4440

aagatcatga gaaaacttgt aagaagacta catcacaaac tcaagaacgg tgaatgtaac     4500

gaggaatttt ttctagacct cttcaacagg gaaaagaaag aggccatcct tcaattggga     4560

gagattcttg gtcttgagga tgatcttaat gagttggcaa gcatcaattg gttgaatctg     4620

aatgaaatgt tcccattgag gatggttctg agacaaaaag tggtttaccc atcagtaatg     4680

acctttcaag aggaaaagat cccctcattg attaaaacac tccaaaataa gctttgtagt     4740

aagttcacaa gaggtgcaca gaagctgttg tcagaggcaa tcaacaaatc agcttttcag     4800

agttgtgtct catccggctt tataggtctc tgtaagactt taggaagtag gtgtgtgaga     4860

aataaaaaca gggaaaatat gtatatcaga aaggtgcttg aagatctgac catggatgaa     4920

catgtcacaa gggttcacaa acaagatggt gtgatgttgt acatttgcga caagcagaga     4980

cacccagagg ctcaccgtga ccacatcaac cttttgaggc cccttctctg ggactacatt     5040

tgcatctcat tgagcaactc ttttgagctg ggtgtttggg ttttagcaga acctgtgaaa     5100

ggaaagaacg agagtaattc ggctgttagg cacttaaatc catgtgatta tgtagcaaga     5160

aaacctgaga gttcgagact actagaggat aaagtgagtt tgaatcatgt aattcaatct     5220

gtgaggcgac tgtaccccaa aatctttgag gatcagttgc tcccattcat gtctgatgtg     5280

agctcaaaaa atatgagatg gagtcccagg attaaattcc ttgacctttg tgtgctgatt     5340

gacatcaact cagagtcttt gtcactcatt tctcatgttg tcaaatggaa gagggacgaa     5400

cattacactg tgctgttttc tgatctcgtc aactctcacc aacggtcaga ctcaagttta     5460

gttgatgaat ttgttgtcag cacaagggat gtctgcaaga actttttgaa gcaagtgtat     5520

ttcgaatcat ttgtacgaga gtttgttgca acagctagga ccttaggtaa cttttcatgg     5580

ttcccccata aggacatgat gccatctgaa gatggcgctg aagcactggg acccttccaa     5640

tcatttattt tgaaagtggt gaacaagaaa atagagaggc ccatgtttag gaatgacttg     5700

cagtttggtt ttggttggtt ctcttatcgt gtgggggatg ttgtgtgtaa tgccgctatg     5760

ttaattaagc agggtttgac agatccaaaa gcatttaaat ctttaagaga tttgtgggat     5820

tacatgctca gcagcacaga ggggatattg gagttctcaa tcacagtgga tttcacacac     5880

aaccagaaca acactgactg cttgaggaaa ttttcattga tctttgtggt taaatgccaa     5940

ttacagagtc caggtgtagc tgattactta tcgtgctctc attccttcaa aggtgaggtt     6000

gacaggagat tattagatga gtgtctcaat ctgttgagga cagaccccat ctttaaagcg     6060

aatgatggag tctttgacat taggtctgaa gagtttgaag attacatgga agaccctttg     6120

acacttggtg attcactaga acttgaacta ataggttcta gaaggattct gaatgagatc     6180

aaatctactg actttgagag gatagggcct gagtgggaac ctgtgcctct gaccataagg     6240

aagggtgccc tctttgaggg gaggaacttt gttcagaatr tctctgtgaa attggagaca     6300

aaggacatga gggtctttct ggcagagctc gagggctgtg gaaaaattgg tgatgtcctc     6360

ggcagcctcc tcctgcaccg attcagaact ggtgagcact tgatggagtc agaaataagt     6420

rcagttcttc aggagctctg catggacaga tccgtcatgc tgacaccatt atcttttgtg     6480

ccagattggt tcaccttcag agattgtagg ctctgcttca gcaggtcaaa gaacactgta     6540

atgtatgaga caactggggg caggttcaga ctcaagggga aatcctgtga cgattggctg     6600

gcggagcggg tggccgagga gatcgactag                                      6630


<210>  32
<211>  2209
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52)


<220>
<221>  MISC_FEATURE
<222>  (2094)..(2094)
<223>  Xaa can be Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (2141)..(2141)
<223>  Xaa can be Thr or Ala

<400>  32

Met Asp Glu Thr Ile Ala Asp Leu Arg Glu Leu Cys Leu Asn Tyr Ile 
1               5                   10                  15      


Glu Gln Asp Glu Arg Leu Ser Arg Gln Lys Leu Asn Phe Leu Gly Gln 
            20                  25                  30          


Arg Glu Pro Arg Met Val Leu Ile Glu Gly Leu Lys Leu Leu Ser Arg 
        35                  40                  45              


Cys Ile Glu Ile Asp Ser Ala Asp Lys Ser Gly Cys Ile His Asn His 
    50                  55                  60                  


Asp Asp Lys Ser Val Glu Thr Ile Leu Ile Asp Ser Gly Ile Val Cys 
65                  70                  75                  80  


Pro Gly Leu Pro Leu Ile Ile Pro Asp Gly Tyr Lys Leu Ile Asp Asn 
                85                  90                  95      


Ser Leu Ile Leu Leu Glu Cys Phe Val Arg Ser Thr Pro Ala Ser Phe 
            100                 105                 110         


Glu Lys Lys Phe Ile Glu Asp Thr Asn Lys Leu Ala Cys Ile Lys Glu 
        115                 120                 125             


Asp Leu Ala Val Ala Gly Ile Thr Leu Val Pro Ile Val Asp Gly Arg 
    130                 135                 140                 


Cys Asp Tyr Asp Asn Ser Phe Met Pro Glu Trp Val Asn Phe Lys Phe 
145                 150                 155                 160 


Arg Asp Leu Leu Phe Lys Leu Leu Glu Tyr Ser Ser Gln Asp Glu Lys 
                165                 170                 175     


Val Phe Glu Glu Ser Glu Tyr Phe Arg Leu Cys Glu Ser Leu Lys Thr 
            180                 185                 190         


Thr Val Asp Lys Arg Ser Gly Met Asp Ser Met Lys Ile Leu Lys Asp 
        195                 200                 205             


Ala Arg Ser Phe His Asn Asp Glu Ile Met Lys Met Cys His Asp Gly 
    210                 215                 220                 


Val Asn Pro Asn Met Ser Cys Asp Asp Val Val Phe Gly Ile Asn Ser 
225                 230                 235                 240 


Phe Phe Gly Arg Phe Arg Arg Asp Leu Leu Asn Gly Lys Leu Lys Arg 
                245                 250                 255     


Asn Phe Gln Lys Val Ser Pro Gly Gly Leu Ile Lys Glu Phe Ser Glu 
            260                 265                 270         


Leu Tyr Glu Thr Leu Thr Asp Asn Asp Asp Ile Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Ala Val Glu Ser Cys Pro Leu Met Arg Phe Ile Thr Ala Glu Thr 
    290                 295                 300                 


His Gly His Glu Arg Gly Ser Asp Ala Asn Thr Glu Tyr Glu Arg Leu 
305                 310                 315                 320 


Leu Ser Met Leu Asn Lys Val Lys Ser Leu Lys Leu Leu Asn Thr Arg 
                325                 330                 335     


Arg Arg Gln Leu Leu Asn Leu Asp Val Leu Cys Leu Ser Ser Leu Ile 
            340                 345                 350         


Lys Gln Ser Ile Ser Lys Gly Leu Glu Asn Asp Lys His Trp Val Gly 
        355                 360                 365             


Cys Cys Tyr Ser Ser Val Asn Asp Arg Leu Val Ser Leu Gln Ser Thr 
    370                 375                 380                 


Lys Glu Glu Phe Met Arg Leu Leu Lys Asn Arg Arg Lys Ser Arg Val 
385                 390                 395                 400 


His Lys Lys Ala Ser Leu Asp Glu Leu Phe Arg Val Ser Ile Asn Glu 
                405                 410                 415     


Phe Ile Ala Lys Ile Gln Lys Cys Leu Ser Thr Val Gly Leu Ser Phe 
            420                 425                 430         


Glu His Tyr Gly Leu Ser Glu Cys Leu Val Gln Glu Cys His Ile Pro 
        435                 440                 445             


Phe Ala Glu Phe Glu Asn Phe Met Arg Ala Gly Thr His Pro Val Met 
    450                 455                 460                 


His Tyr Thr Lys Phe Glu Asp Tyr Thr Phe Gln Pro Asn Ile Glu Gln 
465                 470                 475                 480 


Leu Arg Gly Leu Gln Ser Leu Arg Lys Leu Ser Ser Val Cys Leu Ala 
                485                 490                 495     


Leu Thr Asn Ser Met Lys Thr Ser Ser Val Ala Arg Leu Arg Gln Asn 
            500                 505                 510         


Gln Leu Gly Ser Val Arg Tyr Gln Val Val Glu Cys Lys Glu Val Phe 
        515                 520                 525             


Cys Gln Ile Ile Lys Leu Asp Ser Glu Glu Tyr His Leu Leu Tyr Gln 
    530                 535                 540                 


Lys Thr Gly Glu Ser Ser Arg Cys Tyr Ser Ile Gln Gly Pro Asp Gly 
545                 550                 555                 560 


His Leu Ile Ser Phe Tyr Ala Asp Pro Lys Arg Phe Phe Leu Pro Ile 
                565                 570                 575     


Phe Ser Asp Glu Val Leu His Asn Met Ile Asp Thr Met Ile Ser Trp 
            580                 585                 590         


Ile Arg Ser Cys Pro Asp Leu Lys Asp Ser Leu Ile Asp Ile Glu Thr 
        595                 600                 605             


Ala Leu Arg Thr Leu Ile Leu Leu Met Leu Thr Asn Pro Thr Lys Arg 
    610                 615                 620                 


Asn Gln Lys Gln Val Gln Asn Ile Arg Tyr Leu Val Met Ala Ile Val 
625                 630                 635                 640 


Ser Asp Phe Ser Ser Thr Ser Leu Met Asp Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Ile Thr Pro Ala Glu Lys Val Val Tyr Arg Leu Leu Arg Phe Leu Ile 
            660                 665                 670         


Arg Thr Ile Phe Gly Thr Gly Glu Lys Val Leu Leu Ser Ala Lys Phe 
        675                 680                 685             


Lys Phe Met Leu Asn Val Ser Tyr Leu Cys His Leu Ile Thr Lys Glu 
    690                 695                 700                 


Thr Pro Asp Arg Leu Thr Asp Gln Ile Lys Cys Phe Glu Lys Phe Phe 
705                 710                 715                 720 


Glu Pro Lys Ser Glu Phe Gly Phe Phe Val Asn Pro Lys Glu Thr Ile 
                725                 730                 735     


Thr Pro Glu Glu Glu Cys Val Phe Tyr Glu Gln Met Lys Lys Phe Thr 
            740                 745                 750         


Gly Lys Asp Ile Asp Cys Gln His Ser Thr Pro Gly Val Asn Leu Glu 
        755                 760                 765             


Ile Phe Ser Met Met Val Ser Ser Phe Asn Asn Gly Thr Leu Ile Leu 
    770                 775                 780                 


Lys Gly Glu Lys Arg Leu Asn Asn Leu Asp Pro Met Thr Asn Ser Gly 
785                 790                 795                 800 


Cys Ala Thr Ala Leu Asp Leu Ala Ser Asn Lys Ser Val Val Val Asn 
                805                 810                 815     


Lys His Leu Asn Gly Glu Arg Leu Leu Glu Tyr Asp Phe Asn Lys Leu 
            820                 825                 830         


Leu Val Ser Ala Val Ser Gln Ile Thr Glu Gly Phe Met Arg Lys Gln 
        835                 840                 845             


Lys Tyr Lys Leu Arg His Ser Asp Tyr Glu Tyr Lys Val Ser Lys Leu 
    850                 855                 860                 


Val Ser Arg Leu Val Ile Gly Ser Arg Lys Thr Glu Val Asp Lys Leu 
865                 870                 875                 880 


Glu Asp Asp Pro Val Asp Val Cys Phe Glu Gly Glu Glu Glu Thr Ser 
                885                 890                 895     


Phe Phe Arg Ser Leu Glu Asp Lys Val Ser Ser Thr Ile Thr Arg Tyr 
            900                 905                 910         


Asn Arg Gly Thr Arg Leu Asn Glu Gly Gln Gly Glu Gly Glu Phe Lys 
        915                 920                 925             


Asn Thr Lys Gly Leu His His Leu Gln Ile Ile Leu Ser Gly Lys Arg 
    930                 935                 940                 


Ala Tyr Leu Arg Lys Val Ile Leu Ser Glu Ile Ser Phe His Leu Val 
945                 950                 955                 960 


Glu Asp Phe Asp Pro Ser Cys Leu Thr Asn Asp Asp Met Arg Phe Ile 
                965                 970                 975     


Cys Glu Ala Val Glu Gly Ser Thr Glu Leu Ser Pro Leu Tyr Phe Thr 
            980                 985                 990         


Ser Ala Val Lys Glu Gln Cys Gly  Leu Asp Glu Met Ala  Arg Asn Leu 
        995                 1000                 1005             


Cys Arg  Lys Phe Phe Ser Glu  Gly Asp Trp Phe Ser  Cys Met Lys 
    1010                 1015                 1020             


Met Ile  Leu Leu Gln Met Asn  Ala Asn Ala Tyr Ser  Gly Lys Tyr 
    1025                 1030                 1035             


Arg His  Met Gln Arg Gln Ser  Leu Asn Phe Lys Phe  Asp Trp Asp 
    1040                 1045                 1050             


Lys Leu  Glu Glu Asp Val Arg  Ile Ser Glu Arg Glu  Ser Asn Ser 
    1055                 1060                 1065             


Glu Ser  Leu Ser Lys Ala Leu  Ser Leu Thr Lys Cys  Met Ser Ala 
    1070                 1075                 1080             


Ala Leu  Lys Asn Leu Cys Phe  Tyr Ser Glu Glu Ser  Pro Thr Ser 
    1085                 1090                 1095             


Tyr Thr  Ser Val Gly Pro Asp  Ser Gly Arg Leu Lys  Phe Ala Leu 
    1100                 1105                 1110             


Ser Tyr  Lys Glu Gln Val Gly  Gly Asn Arg Glu Leu  Tyr Ile Gly 
    1115                 1120                 1125             


Asp Leu  Arg Thr Lys Met Phe  Thr Arg Leu Val Glu  Asp Tyr Phe 
    1130                 1135                 1140             


Glu Ser  Phe Ser Ser Phe Phe  Ser Gly Ser Cys Leu  Asn Asn Asp 
    1145                 1150                 1155             


Lys Glu  Phe Glu Asn Ala Ile  Leu Ser Met Thr Ile  Asn Val Arg 
    1160                 1165                 1170             


Glu Gly  Leu Leu Asn Tyr Ser  Met Asp His Ser Lys  Trp Gly Pro 
    1175                 1180                 1185             


Met Met  Cys Pro Phe Leu Phe  Leu Met Leu Leu Gln  Asn Leu Lys 
    1190                 1195                 1200             


Leu Gly  Asp Asp Gln Tyr Val  Arg Ser Gly Lys Asp  His Val Ser 
    1205                 1210                 1215             


Thr Leu  Leu Thr Trp His Met  His Lys Leu Val Glu  Val Pro Phe 
    1220                 1225                 1230             


Pro Val  Val Asn Ala Met Met  Lys Ser Tyr Val Lys  Ser Lys Leu 
    1235                 1240                 1245             


Lys Leu  Leu Lys Gly Ser Gly  Thr Thr Val Thr Glu  Arg Ile Phe 
    1250                 1255                 1260             


Arg Glu  Tyr Phe Glu Met Gly  Val Val Pro Ser His  Ile Ser Ser 
    1265                 1270                 1275             


Leu Ile  Asp Met Gly Gln Gly  Ile Leu His Asn Ala  Ser Asp Phe 
    1280                 1285                 1290             


Tyr Gly  Leu Ile Ser Glu Arg  Phe Ile Asn Tyr Cys  Ile Gly Val 
    1295                 1300                 1305             


Ile Phe  Gly Glu Arg Pro Glu  Ala Tyr Thr Ser Ser  Asp Asp Gln 
    1310                 1315                 1320             


Ile Thr  Leu Phe Asp Lys Arg  Leu Ser Asp Leu Val  Asp Ser Asp 
    1325                 1330                 1335             


Pro Glu  Glu Val Leu Val Leu  Leu Glu Phe His Ser  His Leu Ser 
    1340                 1345                 1350             


Gly Leu  Leu Asn Lys Phe Ile  Ser Pro Lys Ser Val  Val Gly Arg 
    1355                 1360                 1365             


Phe Ala  Ala Glu Phe Lys Ser  Arg Phe Tyr Val Trp  Gly Glu Glu 
    1370                 1375                 1380             


Val Pro  Leu Leu Thr Lys Phe  Val Ser Ala Ala Leu  His Asn Val 
    1385                 1390                 1395             


Lys Cys  Lys Glu Pro His Gln  Leu Cys Glu Thr Ile  Asp Thr Ile 
    1400                 1405                 1410             


Ala Asp  Gln Ala Ile Ala Asn  Gly Val Pro Val Phe  Leu Val Asn 
    1415                 1420                 1425             


Cys Ile  Gln Arg Arg Thr Leu  Asp Leu Leu Lys Tyr  Ala Asn Phe 
    1430                 1435                 1440             


Pro Leu  Asp Pro Phe Leu Leu  Asn Thr His Thr Asp  Val Lys Asp 
    1445                 1450                 1455             


Trp Leu  Asp Gly Ser Arg Gly  Tyr Arg Ile Gln Arg  Leu Ile Glu 
    1460                 1465                 1470             


Glu Leu  Cys Pro Ser Glu Thr  Lys Ile Met Arg Lys  Leu Val Arg 
    1475                 1480                 1485             


Arg Leu  His His Lys Leu Lys  Asn Gly Glu Cys Asn  Glu Glu Phe 
    1490                 1495                 1500             


Phe Leu  Asp Leu Phe Asn Arg  Glu Lys Lys Glu Ala  Ile Leu Gln 
    1505                 1510                 1515             


Leu Gly  Glu Ile Leu Gly Leu  Glu Asp Asp Leu Asn  Glu Leu Ala 
    1520                 1525                 1530             


Ser Ile  Asn Trp Leu Asn Leu  Asn Glu Met Phe Pro  Leu Arg Met 
    1535                 1540                 1545             


Val Leu  Arg Gln Lys Val Val  Tyr Pro Ser Val Met  Thr Phe Gln 
    1550                 1555                 1560             


Glu Glu  Lys Ile Pro Ser Leu  Ile Lys Thr Leu Gln  Asn Lys Leu 
    1565                 1570                 1575             


Cys Ser  Lys Phe Thr Arg Gly  Ala Gln Lys Leu Leu  Ser Glu Ala 
    1580                 1585                 1590             


Ile Asn  Lys Ser Ala Phe Gln  Ser Cys Val Ser Ser  Gly Phe Ile 
    1595                 1600                 1605             


Gly Leu  Cys Lys Thr Leu Gly  Ser Arg Cys Val Arg  Asn Lys Asn 
    1610                 1615                 1620             


Arg Glu  Asn Met Tyr Ile Arg  Lys Val Leu Glu Asp  Leu Thr Met 
    1625                 1630                 1635             


Asp Glu  His Val Thr Arg Val  His Lys Gln Asp Gly  Val Met Leu 
    1640                 1645                 1650             


Tyr Ile  Cys Asp Lys Gln Arg  His Pro Glu Ala His  Arg Asp His 
    1655                 1660                 1665             


Ile Asn  Leu Leu Arg Pro Leu  Leu Trp Asp Tyr Ile  Cys Ile Ser 
    1670                 1675                 1680             


Leu Ser  Asn Ser Phe Glu Leu  Gly Val Trp Val Leu  Ala Glu Pro 
    1685                 1690                 1695             


Val Lys  Gly Lys Asn Glu Ser  Asn Ser Ala Val Arg  His Leu Asn 
    1700                 1705                 1710             


Pro Cys  Asp Tyr Val Ala Arg  Lys Pro Glu Ser Ser  Arg Leu Leu 
    1715                 1720                 1725             


Glu Asp  Lys Val Ser Leu Asn  His Val Ile Gln Ser  Val Arg Arg 
    1730                 1735                 1740             


Leu Tyr  Pro Lys Ile Phe Glu  Asp Gln Leu Leu Pro  Phe Met Ser 
    1745                 1750                 1755             


Asp Val  Ser Ser Lys Asn Met  Arg Trp Ser Pro Arg  Ile Lys Phe 
    1760                 1765                 1770             


Leu Asp  Leu Cys Val Leu Ile  Asp Ile Asn Ser Glu  Ser Leu Ser 
    1775                 1780                 1785             


Leu Ile  Ser His Val Val Lys  Trp Lys Arg Asp Glu  His Tyr Thr 
    1790                 1795                 1800             


Val Leu  Phe Ser Asp Leu Val  Asn Ser His Gln Arg  Ser Asp Ser 
    1805                 1810                 1815             


Ser Leu  Val Asp Glu Phe Val  Val Ser Thr Arg Asp  Val Cys Lys 
    1820                 1825                 1830             


Asn Phe  Leu Lys Gln Val Tyr  Phe Glu Ser Phe Val  Arg Glu Phe 
    1835                 1840                 1845             


Val Ala  Thr Ala Arg Thr Leu  Gly Asn Phe Ser Trp  Phe Pro His 
    1850                 1855                 1860             


Lys Asp  Met Met Pro Ser Glu  Asp Gly Ala Glu Ala  Leu Gly Pro 
    1865                 1870                 1875             


Phe Gln  Ser Phe Ile Leu Lys  Val Val Asn Lys Lys  Ile Glu Arg 
    1880                 1885                 1890             


Pro Met  Phe Arg Asn Asp Leu  Gln Phe Gly Phe Gly  Trp Phe Ser 
    1895                 1900                 1905             


Tyr Arg  Val Gly Asp Val Val  Cys Asn Ala Ala Met  Leu Ile Lys 
    1910                 1915                 1920             


Gln Gly  Leu Thr Asp Pro Lys  Ala Phe Lys Ser Leu  Arg Asp Leu 
    1925                 1930                 1935             


Trp Asp  Tyr Met Leu Ser Ser  Thr Glu Gly Ile Leu  Glu Phe Ser 
    1940                 1945                 1950             


Ile Thr  Val Asp Phe Thr His  Asn Gln Asn Asn Thr  Asp Cys Leu 
    1955                 1960                 1965             


Arg Lys  Phe Ser Leu Ile Phe  Val Val Lys Cys Gln  Leu Gln Ser 
    1970                 1975                 1980             


Pro Gly  Val Ala Asp Tyr Leu  Ser Cys Ser His Ser  Phe Lys Gly 
    1985                 1990                 1995             


Glu Val  Asp Arg Arg Leu Leu  Asp Glu Cys Leu Asn  Leu Leu Arg 
    2000                 2005                 2010             


Thr Asp  Pro Ile Phe Lys Ala  Asn Asp Gly Val Phe  Asp Ile Arg 
    2015                 2020                 2025             


Ser Glu  Glu Phe Glu Asp Tyr  Met Glu Asp Pro Leu  Thr Leu Gly 
    2030                 2035                 2040             


Asp Ser  Leu Glu Leu Glu Leu  Ile Gly Ser Arg Arg  Ile Leu Asn 
    2045                 2050                 2055             


Glu Ile  Lys Ser Thr Asp Phe  Glu Arg Ile Gly Pro  Glu Trp Glu 
    2060                 2065                 2070             


Pro Val  Pro Leu Thr Ile Arg  Lys Gly Ala Leu Phe  Glu Gly Arg 
    2075                 2080                 2085             


Asn Phe  Val Gln Asn Xaa Ser  Val Lys Leu Glu Thr  Lys Asp Met 
    2090                 2095                 2100             


Arg Val  Phe Leu Ala Glu Leu  Glu Gly Cys Gly Lys  Ile Gly Asp 
    2105                 2110                 2115             


Val Leu  Gly Ser Leu Leu Leu  His Arg Phe Arg Thr  Gly Glu His 
    2120                 2125                 2130             


Leu Met  Glu Ser Glu Ile Ser  Xaa Val Leu Gln Glu  Leu Cys Met 
    2135                 2140                 2145             


Asp Arg  Ser Val Met Leu Thr  Pro Leu Ser Phe Val  Pro Asp Trp 
    2150                 2155                 2160             


Phe Thr  Phe Arg Asp Cys Arg  Leu Cys Phe Ser Arg  Ser Lys Asn 
    2165                 2170                 2175             


Thr Val  Met Tyr Glu Thr Thr  Gly Gly Arg Phe Arg  Leu Lys Gly 
    2180                 2185                 2190             


Lys Ser  Cys Asp Asp Trp Leu  Ala Glu Arg Val Ala  Glu Glu Ile 
    2195                 2200                 2205             


Asp 
    


<210>  33
<211>  1497
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P91)

<400>  33
atgggtcaga ttgtgacaat gtttgaggct ttgcctcaca tcattgatga ggtcatcaac       60

attgtcatta ttgtgctcat tataatcacg agcatcaaag ctgtgtacaa tttcgccacc      120

tgtgggatat tagcactggt cagcttcctt tttttggctg gtaggtcctg tggcatgtac      180

ggccttaatg gtcccgacat ctataaaggg gtttaccagt tcaaatcagt ggagtttgat      240

atgtctcact taaatctgac gatgcccaat gcgtgctcag ccaacaactc tcatcactac      300

atcagtatgg gaagctctgg actggagcta actttcacta acgactccat ccttaatcac      360

aatttttgca acttaacctc cgctttcaac aaaaagactt ttgaccatac actcatgagt      420

atagtctcga gtctgcacct cagtattaga gggaattcca accacaaagc agtgtcttgt      480

gattttaaca atggcatcac cattcaatac aacttgtcat tttcggaccc acagagcgct      540

atgagccagt gttggacttt cagaggtaga gtcttggaca tgtttagaac tgcctttgga      600

ggaaaataca tgagaagtgg ctggggctgg gcaggttcag atggcaagac cacttggtgc      660

agccaaacaa gctatcagta cctaatcata caaaacagga cttgggaaaa ccactgtaga      720

tatgcaggcc cttttgggat gtctagaatc ctctttgctc aggaaaagac aaagtttctc      780

actaggagac ttgcaggcac attcacctgg accctgtcag actcctcagg agtagaaaat      840

ccaggtggtt attgcctgac caaatggatg atccttgctg cagagctcaa atgttttggg      900

aatacagctg ttgcaaaatg taatgtcaat catgatgaag agttctgtga catgctacga      960

ctaattgatt acaacaaggc cgccctgagt aagttcaagc aagatgtaga gtctgccttg     1020

catgtattca aaacaacagt aaattctctg atttccgatc agctgttgat gaggaatcat     1080

ctaagagatc taatgggggt accatactgt aattactcaa agttctggta tctggaacat     1140

gctaagactg gtgagactag tgtacccaag tgctggcttg tcactaatgg ctcctacttg     1200

aatgagaccc actttagtga tcaaatcgaa caagaagcag ataacatgat cacagagatg     1260

ttgaggaagg actacataaa aagacaaggg agtactcctt tagccttaat ggatcttttg     1320

atgttttcaa catcagcata tctaatcagc atctttctgc atcttgtgaa gataccaaca     1380

catagacaca taaagggcgg ttcatgtcca aagccacacc gcttgaccaa caaggggatc     1440

tgtagttgtg gtgcattcaa ggtgcctggt gtaaaaacta tctggaaaag acgctga        1497


<210>  34
<211>  498
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P91)

<400>  34

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Asn Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Ser Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Leu Asn His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn His Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Ser Phe Ser Asp 
                165                 170                 175     


Pro Gln Ser Ala Met Ser Gln Cys Trp Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Ala Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Arg 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Phe Ala Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Gln Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Val Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Ile Trp Lys 
                485                 490                 495     


Arg Arg 
        


<210>  35
<211>  1677
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P91)

<400>  35
atgtctttgt ccaaagaagt caaaagcttt cagtggacac aggcgttgag gagggagttg       60

cagagtttta catcagatgt aaaggctgcc gtcatcaagg acgcaaccag tcttctaaat      120

gggttggact tttctgaagt cagcaacgtt cagaggatca tgagaaagga aaggagggat      180

gataaagact tgcagagact caggagtctt aaccagactg tgcattctct tgttgatctg      240

aagtctacat caaagaaaaa tgttctgaaa gtgggaagac ttagtgcaga ggaattgatg      300

acccttgcag ctgatcttga gaagctgaag gccaaaatta tgagaactga gaggcctcaa      360

gcttctggag tctacatggg aaatttgaca gcacaacaac ttgatcaaag atcccaaata      420

ctgcaaatgg ttgggatgag aagacctcag cagggtgcaa gtggtgtagt aagggtttgg      480

gatgtgaagg actcatcact tctgaacaat cagttcggca caatgccaag cctgacaatg      540

gcttgcatgg caaaacagtc acagacccca ctcaatgatg ttgtgcaggc actcacagac      600

cttggcttac tttacacagt caaatacccg aatctcagtg atcttgaaag gctaaaggat      660

aaacacccag ttctgggggt cattactgaa cagcaatcta gtatcaatat ctctggttat      720

aatttcagtc ttggtgcagc tgtgaaagcg ggggcagctc tgctagatgg agggaacatg      780

ctggaatcta tcttgatcaa accgagcaac agtgaggatc tcctaaaagc agtcctcggg      840

gccaagaaga aactcaacat gtttgtctca gatcaagttg gagatagaaa tccctatgaa      900

aacatccttt ataaagtctg tctttcaggt gaaggatggc catacatagc ctgtagaacg      960

tcagttgtgg ggagagcatg ggagaacaca acaattgatc tcacaaatga aaaacttgtt     1020

gccaactcat ctaggccagt gcctggagca gcaggcccac ctcaggtggg cttgagttac     1080

agtcagacaa tgctgttgaa agacttgatg ggagggattg atcccaatgc tcccacatgg     1140

attgacattg agggcaggtt caatgatcca gtggagatag caatattcca accacaaaat     1200

gggcaattca tacattttta cagggaacct acggaccaga agcaattcaa gcaggactca     1260

aagtattcac acggcatgga tcttgctgat ctcttcaatg cacagcctgg gctgacctca     1320

tcagttatag gtgctctccc acaagggatg gttttgagct gtcaaggttc tgatgacatc     1380

agaaagcttc tggactcaca aaatagaagg gacataaaac tcattgatgt tgagatgacc     1440

aaggaggcct caagagaata tgaagataaa gtgtgggaca aatatggctg gctatgcaaa     1500

atgcacactg gggtagtgag agacaaaaag aagaaagaga tcaccccaca ctgtgcactc     1560

atggactgca tcatttttga gagtgcttcc aaggcaagac tccctgatct aaaaaccgtt     1620

cacaacatcc tgccacatga tttaatcttc agaggaccca atgttgtgac actctaa        1677


<210>  36
<211>  558
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P91)

<400>  36

Met Ser Leu Ser Lys Glu Val Lys Ser Phe Gln Trp Thr Gln Ala Leu 
1               5                   10                  15      


Arg Arg Glu Leu Gln Ser Phe Thr Ser Asp Val Lys Ala Ala Val Ile 
            20                  25                  30          


Lys Asp Ala Thr Ser Leu Leu Asn Gly Leu Asp Phe Ser Glu Val Ser 
        35                  40                  45              


Asn Val Gln Arg Ile Met Arg Lys Glu Arg Arg Asp Asp Lys Asp Leu 
    50                  55                  60                  


Gln Arg Leu Arg Ser Leu Asn Gln Thr Val His Ser Leu Val Asp Leu 
65                  70                  75                  80  


Lys Ser Thr Ser Lys Lys Asn Val Leu Lys Val Gly Arg Leu Ser Ala 
                85                  90                  95      


Glu Glu Leu Met Thr Leu Ala Ala Asp Leu Glu Lys Leu Lys Ala Lys 
            100                 105                 110         


Ile Met Arg Thr Glu Arg Pro Gln Ala Ser Gly Val Tyr Met Gly Asn 
        115                 120                 125             


Leu Thr Ala Gln Gln Leu Asp Gln Arg Ser Gln Ile Leu Gln Met Val 
    130                 135                 140                 


Gly Met Arg Arg Pro Gln Gln Gly Ala Ser Gly Val Val Arg Val Trp 
145                 150                 155                 160 


Asp Val Lys Asp Ser Ser Leu Leu Asn Asn Gln Phe Gly Thr Met Pro 
                165                 170                 175     


Ser Leu Thr Met Ala Cys Met Ala Lys Gln Ser Gln Thr Pro Leu Asn 
            180                 185                 190         


Asp Val Val Gln Ala Leu Thr Asp Leu Gly Leu Leu Tyr Thr Val Lys 
        195                 200                 205             


Tyr Pro Asn Leu Ser Asp Leu Glu Arg Leu Lys Asp Lys His Pro Val 
    210                 215                 220                 


Leu Gly Val Ile Thr Glu Gln Gln Ser Ser Ile Asn Ile Ser Gly Tyr 
225                 230                 235                 240 


Asn Phe Ser Leu Gly Ala Ala Val Lys Ala Gly Ala Ala Leu Leu Asp 
                245                 250                 255     


Gly Gly Asn Met Leu Glu Ser Ile Leu Ile Lys Pro Ser Asn Ser Glu 
            260                 265                 270         


Asp Leu Leu Lys Ala Val Leu Gly Ala Lys Lys Lys Leu Asn Met Phe 
        275                 280                 285             


Val Ser Asp Gln Val Gly Asp Arg Asn Pro Tyr Glu Asn Ile Leu Tyr 
    290                 295                 300                 


Lys Val Cys Leu Ser Gly Glu Gly Trp Pro Tyr Ile Ala Cys Arg Thr 
305                 310                 315                 320 


Ser Val Val Gly Arg Ala Trp Glu Asn Thr Thr Ile Asp Leu Thr Asn 
                325                 330                 335     


Glu Lys Leu Val Ala Asn Ser Ser Arg Pro Val Pro Gly Ala Ala Gly 
            340                 345                 350         


Pro Pro Gln Val Gly Leu Ser Tyr Ser Gln Thr Met Leu Leu Lys Asp 
        355                 360                 365             


Leu Met Gly Gly Ile Asp Pro Asn Ala Pro Thr Trp Ile Asp Ile Glu 
    370                 375                 380                 


Gly Arg Phe Asn Asp Pro Val Glu Ile Ala Ile Phe Gln Pro Gln Asn 
385                 390                 395                 400 


Gly Gln Phe Ile His Phe Tyr Arg Glu Pro Thr Asp Gln Lys Gln Phe 
                405                 410                 415     


Lys Gln Asp Ser Lys Tyr Ser His Gly Met Asp Leu Ala Asp Leu Phe 
            420                 425                 430         


Asn Ala Gln Pro Gly Leu Thr Ser Ser Val Ile Gly Ala Leu Pro Gln 
        435                 440                 445             


Gly Met Val Leu Ser Cys Gln Gly Ser Asp Asp Ile Arg Lys Leu Leu 
    450                 455                 460                 


Asp Ser Gln Asn Arg Arg Asp Ile Lys Leu Ile Asp Val Glu Met Thr 
465                 470                 475                 480 


Lys Glu Ala Ser Arg Glu Tyr Glu Asp Lys Val Trp Asp Lys Tyr Gly 
                485                 490                 495     


Trp Leu Cys Lys Met His Thr Gly Val Val Arg Asp Lys Lys Lys Lys 
            500                 505                 510         


Glu Ile Thr Pro His Cys Ala Leu Met Asp Cys Ile Ile Phe Glu Ser 
        515                 520                 525             


Ala Ser Lys Ala Arg Leu Pro Asp Leu Lys Thr Val His Asn Ile Leu 
    530                 535                 540                 


Pro His Asp Leu Ile Phe Arg Gly Pro Asn Val Val Thr Leu 
545                 550                 555             


<210>  37
<211>  273
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P91)

<400>  37
atgggccaag gcaagtccaa agaagaaagg gacaccagca atacaggcag agcagagctt       60

ttgccagaca ccacctatct tggtcctcta aattgtaaat catgttggca gaaatttgac      120

agcttggtta gatgccatga ccactatctt tgcagacact gtctgaatct cctgctgtca      180

gtttccgaca gatgtcctct ctgtaagtat ccactgccaa ccaaactgaa ggtgtcaaca      240

gtcccaagct ccccacctcc ctatgaggag tga                                   273


<210>  38
<211>  90
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P91)

<400>  38

Met Gly Gln Gly Lys Ser Lys Glu Glu Arg Asp Thr Ser Asn Thr Gly 
1               5                   10                  15      


Arg Ala Glu Leu Leu Pro Asp Thr Thr Tyr Leu Gly Pro Leu Asn Cys 
            20                  25                  30          


Lys Ser Cys Trp Gln Lys Phe Asp Ser Leu Val Arg Cys His Asp His 
        35                  40                  45              


Tyr Leu Cys Arg His Cys Leu Asn Leu Leu Leu Ser Val Ser Asp Arg 
    50                  55                  60                  


Cys Pro Leu Cys Lys Tyr Pro Leu Pro Thr Lys Leu Lys Val Ser Thr 
65                  70                  75                  80  


Val Pro Ser Ser Pro Pro Pro Tyr Glu Glu 
                85                  90  


<210>  39
<211>  6630
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P91)

<400>  39
atggatgaaa ctattgcaga tttgagagag ttgtgtctaa attacataga acaggacgag       60

aggctgtcaa ggcaaaaact caacttcctg ggacaaagag aacccagaat ggtgctaatt      120

gagggactca aattgttatc acgctgtata gagatagaca gtgcagacaa aagtggttgc      180

atacacaacc acgatgacaa atctgttgaa acaatcctaa tagactctgg gattgtgtgt      240

ccaggactgc cactcatcat ccctgatggt tataagttga ttgacaattc ccttattctt      300

cttgaatgtt ttgttagaag cacaccagct agttttgaaa agaagttcat tgaggacacc      360

aacaaactag catgcatcaa agaagatctt gctgttgcag gcatcacact ggttccaata      420

gtggatggtc gttgtgatta tgataacagt ttcatgccag aatgggtgaa ttttaagttc      480

agagacctcc tatttaaact cctggagtat tctagtcaag atgagaaagt ttttgaggag      540

tctgaatact tcaggctctg tgagtctctt aagaccactg ttgacaaacg ttccggcatg      600

gactcaatga aaattttgaa agacgcaaga tcatttcata acgatgagat tatgaaaatg      660

tgccacgatg gtgtcaaccc caacatgagt tgcgatgatg tggtctttgg cataaattcc      720

ttttttggca ggtttaggag ggacctgtta aatgggaaac tcaaaaggaa tttccaaaag      780

gtcagccctg ggggcttaat caaggaattc tctgaacttt atgaaaccct tactgataat      840

gatgacatat taatgttgag caaagaggca gttgaatcct gccccttaat gaggttcatt      900

acagcagaga cccatgggca tgagagagga agcgatgcta acactgagta tgaaaggcta      960

ctctctatgt tgaacaaggt gaaaagttta aaattattaa acactagaag gagacagctg     1020

ctgaacttag atgtcttatg tctttcttca cttattaagc agtcaatttc caaagggttg     1080

gaaaatgata aacattgggt tggttgctgc tacagtagtg tgaatgatag gcttgtgagc     1140

cttcaaagta ccaaagaaga attcatgaga cttttgaaga acagaagaaa atcaagagtg     1200

cacaaaaagg catctcttga tgagcttttt agggtatcca taaatgagtt catagcaaaa     1260

atccagaaat gcctatcaac agtgggactt agttttgagc attacggact atcagaatgc     1320

ctcgtgcaag aatgccatat accatttgct gaatttgaga actttatgag agccgggact     1380

catcctgtaa tgcattacac aaaatttgaa gattacactt tccagcctaa catagagcaa     1440

ttgaggggtt tacagagttt gagaaaactg tcatctgttt gtttggctct aacaaacagc     1500

atgaaaacaa gctcagttgc aaggttgaga cagaaccaac tggggtctgt gagatatcaa     1560

gtggtggagt gcaaagaggt gttttgccag ataataaaac tggattccga agagtatcat     1620

ctactatatc agaaaactgg agaatcatcg aggtgttatt ccatacaagg tccggatggt     1680

cacttgattt ccttttacgc agatccaaaa aggttctttt taccaatttt ttcagatgag     1740

gtgttgcaca acatgataga cacaatgatt tcatggatta ggtcatgccc tgacttaaaa     1800

gattctctta ttgacattga gactgcacta aggacattga tcctactgat gctcaccaac     1860

ccaacaaaga gaaatcaaaa gcaggttcaa aatattaggt atttagtgat ggccatcgtc     1920

tcagactttt catcgacctc attaatggat aagttgaagg aggatctaat cacacctgcc     1980

gagaaagtgg tgtacaggct gcttcggttt ttgattagga caatttttgg tactggtgaa     2040

aaggtgttat tgagtgcaaa attcaagttt atgttgaatg tgtcatacct gtgtcatttg     2100

atcacaaagg agacccctga tagattgaca gatcagataa aatgttttga aaagttcttt     2160

gagcccaaga gtgagtttgg tttctttgtc aaccctaagg aaacaatcac acccgaagag     2220

gaatgtgttt tttatgaaca aatgaagaag ttcaccggta aagatattga ttgtcagcat     2280

tcaacccctg gtgttaattt agagatcttt agcatgatgg tatcttcatt caacaatggc     2340

accttaattc taaaagggga gaaaaggctc aacaatctgg accccatgac caactctgga     2400

tgtgcgacag cattagatct cgcaagcaac aaaagtgtgg ttgtcaataa acatctgaat     2460

ggagaacggc ttttggagta tgattttaac aaattgcttg ttagtgctgt gagccaaatt     2520

acagagggct tcatgaggaa acaaaagtat aagctgagac actcagatta cgaatataag     2580

gtctcaaagc ttgtctctag attagtcatc ggttccagga aaacagaagt agacaaattg     2640

gaagatgatc cggtagatgt gtgtttcgag ggggaggagg agacaagttt tttcaggagt     2700

ttagaagata aggtcagctc cacaataaca cggtataata gaggcactag gcttaatgaa     2760

gggcaagggg agggagaatt caagaacaca aaaggactac accaccttca gattattttg     2820

tcaggtaaaa gagcttatct gaggaaagtc attttatcag aaatttcatt tcatctagta     2880

gaggactttg atccatcctg tctcaccaat gacgacatga ggtttatttg tgaggctgtt     2940

gaaggttcaa cagaactgtc accattgtat tttacatcag ctgtcaaaga acaatgtggt     3000

ctggatgaga tggcaagaaa cctctgtaga aagttcttct cagagggtga ttggttctca     3060

tgtatgaaga tgatcttgtt acagatgaat gcaaatgcgt attcagggaa gtacagacac     3120

atgcagaggc agagcttaaa ttttaaattt gactgggaca aattggaaga agatgtaaga     3180

attagtgaaa gggaaagcaa ttctgaatct ctaagtaagg ccctttcatt gacaaaatgc     3240

atgagtgctg ctctaaagaa tctgtgtttt tactcagaag aatcaccaac atcatacact     3300

tcagttggcc ctgactctgg gagactaaaa tttgcattgt catacaaaga gcaggttggg     3360

ggaaatagag agctttacat tggggatttg aggacaaaaa tgttcacaag attggtagaa     3420

gattattttg aatccttttc tagtttcttt tcaggatctt gtttaaacaa tgataaagag     3480

tttgaaaatg caatcttgtc aatgactatc aatgtgagag aagggttgtt aaactacagc     3540

atggatcaca gcaaatgggg accaatgatg tgcccattcc tattcttaat gcttctccaa     3600

aatctcaaac tgggtgatga tcagtacgtg cgttctggaa aagatcatgt tagcaccttg     3660

ttgacttggc atatgcataa acttgttgaa gtccctttcc ctgttgtgaa tgcaatgatg     3720

aaatcatatg ttaaatcaaa actcaagctt ctcaaagggt caggaacgac tgttacggag     3780

agaatcttta gagagtattt tgaaatgggg gtggtgccat ctcacatatc tagtctcatt     3840

gacatgggac aggggatcct acacaatgct tctgattttt acggtttaat tagtgaaagg     3900

tttatcaatt attgtattgg tgtcattttt ggagagaggc cagaagccta tacatcaagt     3960

gatgatcaga tcactttatt tgacaagaga ttgagtgact tagttgatag tgacccagaa     4020

gaagtccttg tcttgctgga attccactct cacttaagtg gtttgttgaa caagttcatc     4080

agtccaaaaa gtgtggttgg gcggtttgca gcggaattca aatccagatt ttatgtgtgg     4140

ggggaggagg tccctctcct cacgaaattt gtgtctgcgg cactacacaa tgttaagtgt     4200

aaagaaccgc atcaactttg tgagacaata gatacgattg ctgatcaagc tatagcaaat     4260

ggagttccag tttttttagt aaactgtatc cagaggagga cactggatct cttgaaatat     4320

gctaatttcc ctttagatcc attcttgtta aacactcaca ctgatgtaaa ggattggtta     4380

gatggttcta gaggttatag aatccaaaga ctcattgaag aattgtgtcc cagtgaaaca     4440

aagatcatga gaaaacttgt aagaagacta catcacaaac tcaagaacgg tgaatgtaac     4500

gaggaatttt ttctagacct cttcaacagg gaaaaggaag aggccatcct tcaattggga     4560

gagattcttg gtcttgagga tgatcttaat gagttggcaa gcatcaattg gttgaatctg     4620

aatgaaatgt tcccattgag gatggttctg agacaaaaag tggtttaccc atcagtaatg     4680

acctttcaag aggaaaagat cccctcattg attaaaacac tccaaaataa gctttgtagt     4740

aagttcacaa gaggtgcaca gaagctgttg tcagaggcaa tcaacaaatc agcttttcag     4800

agttgtgtct catccggctt tataggtctc tgtaagactt taggaagtag gtgtgtgaga     4860

aataaaaaca gggaaaatat gtatatcaga aaggtgcttg aagatctgac catggatgaa     4920

catgtcacaa gggttcacaa acaagatggt gtgatgttgt acatttgcga caagcagaga     4980

cacccagagg ctcaccgtga ccacatcaac cttttgaggc cccttctctg ggactacatt     5040

tgcatctcat tgagcaactc ttttgagctg ggtgtttggg ttttagcaga acctgtgaaa     5100

ggaaagaacg agagtaattc ggctgttagg cacttaaatc catgtgatta tgtagcaaga     5160

aaacctgaga gttcgagact actagaggat aaagtgagtt tgaatcatgt aattcaatct     5220

gtgaggcgac tgtaccccaa aatctttgag gatcagttgc tcccattcat gtctgatgtg     5280

agctcaaaaa atatgagatg gagtcccagg attaaattcc ttgacctttg tgtgctgatt     5340

gacatcaact cagagtcttt gtcactcatt tctcatgttg tcaaatggaa gagggacgaa     5400

cattacactg tgctgttttc tgatctcgtc aactctcacc aacggtcaga ctcaagttta     5460

gttgatgaat ttgttgtcag cacaagggat gtctgcaaga actttttgaa gcaagtgtat     5520

ttcgaatcat ttgtacgaga gtttgttgca acagctagga ccttaggtaa cttttcatgg     5580

ttcccccata aggacatgat gccatctgaa gatggcgctg aagcactggg acccttccaa     5640

tcatttattt tgaaagtggt gaacaagaaa atagagaggc ccatgtttag gaatgacttg     5700

cagtttggtt ttggttggtt ctcttatcgt gtgggggatg ttgtgtgtaa tgccgctatg     5760

ttaattaagc agggtttgac agatccaaaa gcatttaaat ctttaagaga tttgtgggat     5820

tacatgctca gcagcacaga ggggatattg gagttctcaa tcacagtgga tttcacacac     5880

aaccagaaca acactgactg cttgaggaaa ttttcattga tctttgtggt taaatgccaa     5940

ttacagagtc caggtgtagc tgattactta tcgtgctctc attccttcaa aggtgaggtt     6000

gacaggagat tattagatga gtgtctcaat ctgttgagga cagaccccat ctttaaagcg     6060

aatgatggag tctttgacat taggtctgaa gagtttgaag attacatgga agaccctttg     6120

acacttggtg attcactaga acttgaacta ataggttcta gaaggattct gaatgagatc     6180

aaatctactg actttgagag gatagggcct gagtgggaac ctgtgcctct gaccataagg     6240

aagggtgccc tctttgaggg gaggaacttt gttcagaata tctctgtgaa attggagaca     6300

aaggacatga gggtctttct ggcagagctc gagggctgtg gaaaaattgg tgatgtcctc     6360

ggcagcctcc tcctgcaccg attcagaact ggtgagcact tgatggagtc agaaataagt     6420

acagttcttc aggagctctg catggacaga tccgtcatgc tgacaccatt atcttttgtg     6480

ccagattggt tcaccttcag agattgtagg ctctgcttca gcargtcaaa gaacactgta     6540

atgtatgaga caactggggg caggttcaga ctcaagggga aatcctgtga cgattggctg     6600

gcggagcggg tggccgagga gatcgactag                                      6630


<210>  40
<211>  2209
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P91)


<220>
<221>  MISC_FEATURE
<222>  (2175)..(2175)
<223>  Xaa can be Arg or Lys

<400>  40

Met Asp Glu Thr Ile Ala Asp Leu Arg Glu Leu Cys Leu Asn Tyr Ile 
1               5                   10                  15      


Glu Gln Asp Glu Arg Leu Ser Arg Gln Lys Leu Asn Phe Leu Gly Gln 
            20                  25                  30          


Arg Glu Pro Arg Met Val Leu Ile Glu Gly Leu Lys Leu Leu Ser Arg 
        35                  40                  45              


Cys Ile Glu Ile Asp Ser Ala Asp Lys Ser Gly Cys Ile His Asn His 
    50                  55                  60                  


Asp Asp Lys Ser Val Glu Thr Ile Leu Ile Asp Ser Gly Ile Val Cys 
65                  70                  75                  80  


Pro Gly Leu Pro Leu Ile Ile Pro Asp Gly Tyr Lys Leu Ile Asp Asn 
                85                  90                  95      


Ser Leu Ile Leu Leu Glu Cys Phe Val Arg Ser Thr Pro Ala Ser Phe 
            100                 105                 110         


Glu Lys Lys Phe Ile Glu Asp Thr Asn Lys Leu Ala Cys Ile Lys Glu 
        115                 120                 125             


Asp Leu Ala Val Ala Gly Ile Thr Leu Val Pro Ile Val Asp Gly Arg 
    130                 135                 140                 


Cys Asp Tyr Asp Asn Ser Phe Met Pro Glu Trp Val Asn Phe Lys Phe 
145                 150                 155                 160 


Arg Asp Leu Leu Phe Lys Leu Leu Glu Tyr Ser Ser Gln Asp Glu Lys 
                165                 170                 175     


Val Phe Glu Glu Ser Glu Tyr Phe Arg Leu Cys Glu Ser Leu Lys Thr 
            180                 185                 190         


Thr Val Asp Lys Arg Ser Gly Met Asp Ser Met Lys Ile Leu Lys Asp 
        195                 200                 205             


Ala Arg Ser Phe His Asn Asp Glu Ile Met Lys Met Cys His Asp Gly 
    210                 215                 220                 


Val Asn Pro Asn Met Ser Cys Asp Asp Val Val Phe Gly Ile Asn Ser 
225                 230                 235                 240 


Phe Phe Gly Arg Phe Arg Arg Asp Leu Leu Asn Gly Lys Leu Lys Arg 
                245                 250                 255     


Asn Phe Gln Lys Val Ser Pro Gly Gly Leu Ile Lys Glu Phe Ser Glu 
            260                 265                 270         


Leu Tyr Glu Thr Leu Thr Asp Asn Asp Asp Ile Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Ala Val Glu Ser Cys Pro Leu Met Arg Phe Ile Thr Ala Glu Thr 
    290                 295                 300                 


His Gly His Glu Arg Gly Ser Asp Ala Asn Thr Glu Tyr Glu Arg Leu 
305                 310                 315                 320 


Leu Ser Met Leu Asn Lys Val Lys Ser Leu Lys Leu Leu Asn Thr Arg 
                325                 330                 335     


Arg Arg Gln Leu Leu Asn Leu Asp Val Leu Cys Leu Ser Ser Leu Ile 
            340                 345                 350         


Lys Gln Ser Ile Ser Lys Gly Leu Glu Asn Asp Lys His Trp Val Gly 
        355                 360                 365             


Cys Cys Tyr Ser Ser Val Asn Asp Arg Leu Val Ser Leu Gln Ser Thr 
    370                 375                 380                 


Lys Glu Glu Phe Met Arg Leu Leu Lys Asn Arg Arg Lys Ser Arg Val 
385                 390                 395                 400 


His Lys Lys Ala Ser Leu Asp Glu Leu Phe Arg Val Ser Ile Asn Glu 
                405                 410                 415     


Phe Ile Ala Lys Ile Gln Lys Cys Leu Ser Thr Val Gly Leu Ser Phe 
            420                 425                 430         


Glu His Tyr Gly Leu Ser Glu Cys Leu Val Gln Glu Cys His Ile Pro 
        435                 440                 445             


Phe Ala Glu Phe Glu Asn Phe Met Arg Ala Gly Thr His Pro Val Met 
    450                 455                 460                 


His Tyr Thr Lys Phe Glu Asp Tyr Thr Phe Gln Pro Asn Ile Glu Gln 
465                 470                 475                 480 


Leu Arg Gly Leu Gln Ser Leu Arg Lys Leu Ser Ser Val Cys Leu Ala 
                485                 490                 495     


Leu Thr Asn Ser Met Lys Thr Ser Ser Val Ala Arg Leu Arg Gln Asn 
            500                 505                 510         


Gln Leu Gly Ser Val Arg Tyr Gln Val Val Glu Cys Lys Glu Val Phe 
        515                 520                 525             


Cys Gln Ile Ile Lys Leu Asp Ser Glu Glu Tyr His Leu Leu Tyr Gln 
    530                 535                 540                 


Lys Thr Gly Glu Ser Ser Arg Cys Tyr Ser Ile Gln Gly Pro Asp Gly 
545                 550                 555                 560 


His Leu Ile Ser Phe Tyr Ala Asp Pro Lys Arg Phe Phe Leu Pro Ile 
                565                 570                 575     


Phe Ser Asp Glu Val Leu His Asn Met Ile Asp Thr Met Ile Ser Trp 
            580                 585                 590         


Ile Arg Ser Cys Pro Asp Leu Lys Asp Ser Leu Ile Asp Ile Glu Thr 
        595                 600                 605             


Ala Leu Arg Thr Leu Ile Leu Leu Met Leu Thr Asn Pro Thr Lys Arg 
    610                 615                 620                 


Asn Gln Lys Gln Val Gln Asn Ile Arg Tyr Leu Val Met Ala Ile Val 
625                 630                 635                 640 


Ser Asp Phe Ser Ser Thr Ser Leu Met Asp Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Ile Thr Pro Ala Glu Lys Val Val Tyr Arg Leu Leu Arg Phe Leu Ile 
            660                 665                 670         


Arg Thr Ile Phe Gly Thr Gly Glu Lys Val Leu Leu Ser Ala Lys Phe 
        675                 680                 685             


Lys Phe Met Leu Asn Val Ser Tyr Leu Cys His Leu Ile Thr Lys Glu 
    690                 695                 700                 


Thr Pro Asp Arg Leu Thr Asp Gln Ile Lys Cys Phe Glu Lys Phe Phe 
705                 710                 715                 720 


Glu Pro Lys Ser Glu Phe Gly Phe Phe Val Asn Pro Lys Glu Thr Ile 
                725                 730                 735     


Thr Pro Glu Glu Glu Cys Val Phe Tyr Glu Gln Met Lys Lys Phe Thr 
            740                 745                 750         


Gly Lys Asp Ile Asp Cys Gln His Ser Thr Pro Gly Val Asn Leu Glu 
        755                 760                 765             


Ile Phe Ser Met Met Val Ser Ser Phe Asn Asn Gly Thr Leu Ile Leu 
    770                 775                 780                 


Lys Gly Glu Lys Arg Leu Asn Asn Leu Asp Pro Met Thr Asn Ser Gly 
785                 790                 795                 800 


Cys Ala Thr Ala Leu Asp Leu Ala Ser Asn Lys Ser Val Val Val Asn 
                805                 810                 815     


Lys His Leu Asn Gly Glu Arg Leu Leu Glu Tyr Asp Phe Asn Lys Leu 
            820                 825                 830         


Leu Val Ser Ala Val Ser Gln Ile Thr Glu Gly Phe Met Arg Lys Gln 
        835                 840                 845             


Lys Tyr Lys Leu Arg His Ser Asp Tyr Glu Tyr Lys Val Ser Lys Leu 
    850                 855                 860                 


Val Ser Arg Leu Val Ile Gly Ser Arg Lys Thr Glu Val Asp Lys Leu 
865                 870                 875                 880 


Glu Asp Asp Pro Val Asp Val Cys Phe Glu Gly Glu Glu Glu Thr Ser 
                885                 890                 895     


Phe Phe Arg Ser Leu Glu Asp Lys Val Ser Ser Thr Ile Thr Arg Tyr 
            900                 905                 910         


Asn Arg Gly Thr Arg Leu Asn Glu Gly Gln Gly Glu Gly Glu Phe Lys 
        915                 920                 925             


Asn Thr Lys Gly Leu His His Leu Gln Ile Ile Leu Ser Gly Lys Arg 
    930                 935                 940                 


Ala Tyr Leu Arg Lys Val Ile Leu Ser Glu Ile Ser Phe His Leu Val 
945                 950                 955                 960 


Glu Asp Phe Asp Pro Ser Cys Leu Thr Asn Asp Asp Met Arg Phe Ile 
                965                 970                 975     


Cys Glu Ala Val Glu Gly Ser Thr Glu Leu Ser Pro Leu Tyr Phe Thr 
            980                 985                 990         


Ser Ala Val Lys Glu Gln Cys Gly  Leu Asp Glu Met Ala  Arg Asn Leu 
        995                 1000                 1005             


Cys Arg  Lys Phe Phe Ser Glu  Gly Asp Trp Phe Ser  Cys Met Lys 
    1010                 1015                 1020             


Met Ile  Leu Leu Gln Met Asn  Ala Asn Ala Tyr Ser  Gly Lys Tyr 
    1025                 1030                 1035             


Arg His  Met Gln Arg Gln Ser  Leu Asn Phe Lys Phe  Asp Trp Asp 
    1040                 1045                 1050             


Lys Leu  Glu Glu Asp Val Arg  Ile Ser Glu Arg Glu  Ser Asn Ser 
    1055                 1060                 1065             


Glu Ser  Leu Ser Lys Ala Leu  Ser Leu Thr Lys Cys  Met Ser Ala 
    1070                 1075                 1080             


Ala Leu  Lys Asn Leu Cys Phe  Tyr Ser Glu Glu Ser  Pro Thr Ser 
    1085                 1090                 1095             


Tyr Thr  Ser Val Gly Pro Asp  Ser Gly Arg Leu Lys  Phe Ala Leu 
    1100                 1105                 1110             


Ser Tyr  Lys Glu Gln Val Gly  Gly Asn Arg Glu Leu  Tyr Ile Gly 
    1115                 1120                 1125             


Asp Leu  Arg Thr Lys Met Phe  Thr Arg Leu Val Glu  Asp Tyr Phe 
    1130                 1135                 1140             


Glu Ser  Phe Ser Ser Phe Phe  Ser Gly Ser Cys Leu  Asn Asn Asp 
    1145                 1150                 1155             


Lys Glu  Phe Glu Asn Ala Ile  Leu Ser Met Thr Ile  Asn Val Arg 
    1160                 1165                 1170             


Glu Gly  Leu Leu Asn Tyr Ser  Met Asp His Ser Lys  Trp Gly Pro 
    1175                 1180                 1185             


Met Met  Cys Pro Phe Leu Phe  Leu Met Leu Leu Gln  Asn Leu Lys 
    1190                 1195                 1200             


Leu Gly  Asp Asp Gln Tyr Val  Arg Ser Gly Lys Asp  His Val Ser 
    1205                 1210                 1215             


Thr Leu  Leu Thr Trp His Met  His Lys Leu Val Glu  Val Pro Phe 
    1220                 1225                 1230             


Pro Val  Val Asn Ala Met Met  Lys Ser Tyr Val Lys  Ser Lys Leu 
    1235                 1240                 1245             


Lys Leu  Leu Lys Gly Ser Gly  Thr Thr Val Thr Glu  Arg Ile Phe 
    1250                 1255                 1260             


Arg Glu  Tyr Phe Glu Met Gly  Val Val Pro Ser His  Ile Ser Ser 
    1265                 1270                 1275             


Leu Ile  Asp Met Gly Gln Gly  Ile Leu His Asn Ala  Ser Asp Phe 
    1280                 1285                 1290             


Tyr Gly  Leu Ile Ser Glu Arg  Phe Ile Asn Tyr Cys  Ile Gly Val 
    1295                 1300                 1305             


Ile Phe  Gly Glu Arg Pro Glu  Ala Tyr Thr Ser Ser  Asp Asp Gln 
    1310                 1315                 1320             


Ile Thr  Leu Phe Asp Lys Arg  Leu Ser Asp Leu Val  Asp Ser Asp 
    1325                 1330                 1335             


Pro Glu  Glu Val Leu Val Leu  Leu Glu Phe His Ser  His Leu Ser 
    1340                 1345                 1350             


Gly Leu  Leu Asn Lys Phe Ile  Ser Pro Lys Ser Val  Val Gly Arg 
    1355                 1360                 1365             


Phe Ala  Ala Glu Phe Lys Ser  Arg Phe Tyr Val Trp  Gly Glu Glu 
    1370                 1375                 1380             


Val Pro  Leu Leu Thr Lys Phe  Val Ser Ala Ala Leu  His Asn Val 
    1385                 1390                 1395             


Lys Cys  Lys Glu Pro His Gln  Leu Cys Glu Thr Ile  Asp Thr Ile 
    1400                 1405                 1410             


Ala Asp  Gln Ala Ile Ala Asn  Gly Val Pro Val Phe  Leu Val Asn 
    1415                 1420                 1425             


Cys Ile  Gln Arg Arg Thr Leu  Asp Leu Leu Lys Tyr  Ala Asn Phe 
    1430                 1435                 1440             


Pro Leu  Asp Pro Phe Leu Leu  Asn Thr His Thr Asp  Val Lys Asp 
    1445                 1450                 1455             


Trp Leu  Asp Gly Ser Arg Gly  Tyr Arg Ile Gln Arg  Leu Ile Glu 
    1460                 1465                 1470             


Glu Leu  Cys Pro Ser Glu Thr  Lys Ile Met Arg Lys  Leu Val Arg 
    1475                 1480                 1485             


Arg Leu  His His Lys Leu Lys  Asn Gly Glu Cys Asn  Glu Glu Phe 
    1490                 1495                 1500             


Phe Leu  Asp Leu Phe Asn Arg  Glu Lys Glu Glu Ala  Ile Leu Gln 
    1505                 1510                 1515             


Leu Gly  Glu Ile Leu Gly Leu  Glu Asp Asp Leu Asn  Glu Leu Ala 
    1520                 1525                 1530             


Ser Ile  Asn Trp Leu Asn Leu  Asn Glu Met Phe Pro  Leu Arg Met 
    1535                 1540                 1545             


Val Leu  Arg Gln Lys Val Val  Tyr Pro Ser Val Met  Thr Phe Gln 
    1550                 1555                 1560             


Glu Glu  Lys Ile Pro Ser Leu  Ile Lys Thr Leu Gln  Asn Lys Leu 
    1565                 1570                 1575             


Cys Ser  Lys Phe Thr Arg Gly  Ala Gln Lys Leu Leu  Ser Glu Ala 
    1580                 1585                 1590             


Ile Asn  Lys Ser Ala Phe Gln  Ser Cys Val Ser Ser  Gly Phe Ile 
    1595                 1600                 1605             


Gly Leu  Cys Lys Thr Leu Gly  Ser Arg Cys Val Arg  Asn Lys Asn 
    1610                 1615                 1620             


Arg Glu  Asn Met Tyr Ile Arg  Lys Val Leu Glu Asp  Leu Thr Met 
    1625                 1630                 1635             


Asp Glu  His Val Thr Arg Val  His Lys Gln Asp Gly  Val Met Leu 
    1640                 1645                 1650             


Tyr Ile  Cys Asp Lys Gln Arg  His Pro Glu Ala His  Arg Asp His 
    1655                 1660                 1665             


Ile Asn  Leu Leu Arg Pro Leu  Leu Trp Asp Tyr Ile  Cys Ile Ser 
    1670                 1675                 1680             


Leu Ser  Asn Ser Phe Glu Leu  Gly Val Trp Val Leu  Ala Glu Pro 
    1685                 1690                 1695             


Val Lys  Gly Lys Asn Glu Ser  Asn Ser Ala Val Arg  His Leu Asn 
    1700                 1705                 1710             


Pro Cys  Asp Tyr Val Ala Arg  Lys Pro Glu Ser Ser  Arg Leu Leu 
    1715                 1720                 1725             


Glu Asp  Lys Val Ser Leu Asn  His Val Ile Gln Ser  Val Arg Arg 
    1730                 1735                 1740             


Leu Tyr  Pro Lys Ile Phe Glu  Asp Gln Leu Leu Pro  Phe Met Ser 
    1745                 1750                 1755             


Asp Val  Ser Ser Lys Asn Met  Arg Trp Ser Pro Arg  Ile Lys Phe 
    1760                 1765                 1770             


Leu Asp  Leu Cys Val Leu Ile  Asp Ile Asn Ser Glu  Ser Leu Ser 
    1775                 1780                 1785             


Leu Ile  Ser His Val Val Lys  Trp Lys Arg Asp Glu  His Tyr Thr 
    1790                 1795                 1800             


Val Leu  Phe Ser Asp Leu Val  Asn Ser His Gln Arg  Ser Asp Ser 
    1805                 1810                 1815             


Ser Leu  Val Asp Glu Phe Val  Val Ser Thr Arg Asp  Val Cys Lys 
    1820                 1825                 1830             


Asn Phe  Leu Lys Gln Val Tyr  Phe Glu Ser Phe Val  Arg Glu Phe 
    1835                 1840                 1845             


Val Ala  Thr Ala Arg Thr Leu  Gly Asn Phe Ser Trp  Phe Pro His 
    1850                 1855                 1860             


Lys Asp  Met Met Pro Ser Glu  Asp Gly Ala Glu Ala  Leu Gly Pro 
    1865                 1870                 1875             


Phe Gln  Ser Phe Ile Leu Lys  Val Val Asn Lys Lys  Ile Glu Arg 
    1880                 1885                 1890             


Pro Met  Phe Arg Asn Asp Leu  Gln Phe Gly Phe Gly  Trp Phe Ser 
    1895                 1900                 1905             


Tyr Arg  Val Gly Asp Val Val  Cys Asn Ala Ala Met  Leu Ile Lys 
    1910                 1915                 1920             


Gln Gly  Leu Thr Asp Pro Lys  Ala Phe Lys Ser Leu  Arg Asp Leu 
    1925                 1930                 1935             


Trp Asp  Tyr Met Leu Ser Ser  Thr Glu Gly Ile Leu  Glu Phe Ser 
    1940                 1945                 1950             


Ile Thr  Val Asp Phe Thr His  Asn Gln Asn Asn Thr  Asp Cys Leu 
    1955                 1960                 1965             


Arg Lys  Phe Ser Leu Ile Phe  Val Val Lys Cys Gln  Leu Gln Ser 
    1970                 1975                 1980             


Pro Gly  Val Ala Asp Tyr Leu  Ser Cys Ser His Ser  Phe Lys Gly 
    1985                 1990                 1995             


Glu Val  Asp Arg Arg Leu Leu  Asp Glu Cys Leu Asn  Leu Leu Arg 
    2000                 2005                 2010             


Thr Asp  Pro Ile Phe Lys Ala  Asn Asp Gly Val Phe  Asp Ile Arg 
    2015                 2020                 2025             


Ser Glu  Glu Phe Glu Asp Tyr  Met Glu Asp Pro Leu  Thr Leu Gly 
    2030                 2035                 2040             


Asp Ser  Leu Glu Leu Glu Leu  Ile Gly Ser Arg Arg  Ile Leu Asn 
    2045                 2050                 2055             


Glu Ile  Lys Ser Thr Asp Phe  Glu Arg Ile Gly Pro  Glu Trp Glu 
    2060                 2065                 2070             


Pro Val  Pro Leu Thr Ile Arg  Lys Gly Ala Leu Phe  Glu Gly Arg 
    2075                 2080                 2085             


Asn Phe  Val Gln Asn Ile Ser  Val Lys Leu Glu Thr  Lys Asp Met 
    2090                 2095                 2100             


Arg Val  Phe Leu Ala Glu Leu  Glu Gly Cys Gly Lys  Ile Gly Asp 
    2105                 2110                 2115             


Val Leu  Gly Ser Leu Leu Leu  His Arg Phe Arg Thr  Gly Glu His 
    2120                 2125                 2130             


Leu Met  Glu Ser Glu Ile Ser  Thr Val Leu Gln Glu  Leu Cys Met 
    2135                 2140                 2145             


Asp Arg  Ser Val Met Leu Thr  Pro Leu Ser Phe Val  Pro Asp Trp 
    2150                 2155                 2160             


Phe Thr  Phe Arg Asp Cys Arg  Leu Cys Phe Ser Xaa  Ser Lys Asn 
    2165                 2170                 2175             


Thr Val  Met Tyr Glu Thr Thr  Gly Gly Arg Phe Arg  Leu Lys Gly 
    2180                 2185                 2190             


Lys Ser  Cys Asp Asp Trp Leu  Ala Glu Arg Val Ala  Glu Glu Ile 
    2195                 2200                 2205             


Asp 
    


<210>  41
<211>  1497
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-1)

<400>  41
atgggtcaga ttgtgacaat gtttgaggct ttgcctcaca tcattgatga ggtcatcaac       60

attgtcatta ttgtgctcat tataatcacg agcatcaaag ctgtgtacaa tttcgccacc      120

tgtgggatat tagcactggt cagcttcctt tttttggctg gtaggtcctg tggcatgtac      180

ggcctcaatg gtcccgacat ctataaaggg gtttaccagt tcaaatcagt ggagtttgat      240

atgtctcact taaatctgac gatgcccaat gcgtgctcag ccaacaactc tcatcactac      300

atcagtatgg gaagctctgg actggagcta actttcacta acgactccat ccttaatcac      360

aatttttgca acttaacctc cgctttcaac aaaaagactt ttgaccatac actcatgagt      420

atagtctcga gtctgcacct cagtattaga gggaattcca accacaaagc agtgtcttgt      480

gattttaaca atggcatcac cattcaatac aacttgtcat tttcggaccc acagagcgct      540

atgagccagt gttggacttt cagaggtaga gtcttggaca tgtttagaac tgcctttgga      600

ggaaaataca tgagaagtgg ctggggctgg gcaggttcag atggcaagac cacttggtgc      660

agccaaacaa gctatcagta cctaatcata caaaacagga cttgggaaaa ccactgtaga      720

tatgcaggcc cttttgggat gtctagaatc ctctttgctc aggaaaagac aaagtttctc      780

actaggagac ttgcaggcac attcacctgg accctgtcag actcctcagg agtagaaaat      840

ccaggtggtt attgcctgac caaatggatg atccttgctg cagagctcaa atgttttggg      900

aatacagctg ttgcaaaatg taatgtcaat catgatgaag agttctgtga catgctacga      960

ctaattgatt acaacaaggc cgccctgagt aagttcaagc aagatgtaga gtctgccttg     1020

catgtattca aaacaacagt aaattctctg atttccgatc agctgttgat gaggaatcat     1080

ctaagagatc taatgggggt accatactgt aattactcaa agttctggta tctggaacat     1140

gctaagactg gtgagactag tgtacccaag tgctggcttg tcactaatgg ctcctacttg     1200

aatgagaccc actttagtga tcaaatcgaa caagaagcag ataacatgat cacagagatg     1260

ttgaggaagg actacataaa aagacaaggg agtactcctt tagccttaat ggatcttttg     1320

atgttttcaa catcagcata tctaatcagc atctttctgc atcttgtgaa gataccaaca     1380

catagacaca taaagggcgg ttcatgtcca aagccacacc gcttgaccaa caaggggatc     1440

tgtagttgtg gtgcattcaa ggtgcctggt gtaaaaacta tctggaaaag acgctga        1497


<210>  42
<211>  498
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-1)

<400>  42

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Asn Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Ser Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Leu Asn His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn His Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Ser Phe Ser Asp 
                165                 170                 175     


Pro Gln Ser Ala Met Ser Gln Cys Trp Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Ala Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Arg 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Phe Ala Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Gln Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Val Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Ile Trp Lys 
                485                 490                 495     


Arg Arg 
        


<210>  43
<211>  1677
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-1)

<400>  43
atgtctttgt ccaaagaagt caaaagcttt cagtggacac aggcgttgag gagggagttg       60

cagagtttta catcagatgt aaaggctgcc gtcatcaagg acgcaaccag tcttctaaat      120

gggttggact tttctgaagt cagcaacgtt cagaggatca tgagaaagga aaggagggat      180

gataaagact tgcagagact caggagtctt aaccagactg tgcattctct tgttgatctg      240

aagtctacat caaagaaaaa tgttctgaaa gtgggaagac ttagtgcaga ggaattgatg      300

acccttgcag ctgatcttga gaagctgaag gccaaaatta tgagaactga gaggcctcaa      360

gcttctggag tctacatggg aaatttgaca gcacaacaac ttgatcaaag atcccaaata      420

ctgcaaatgg ttgggatgag aagacctcag cagggtgcaa gtggtgtagt aagggtttgg      480

gatgtgaagg actcatcact tctgaacaat cagttcggca caatgccaag cctgacaatg      540

gcttgcatgg caaaacagtc acagacccca ctcaatgatg ttgtgcaggc actcacagac      600

cttggcttac tttacacagt caaatacccg aatctcagtg atcttgaaag gctaaaggat      660

aaacacccag ttctgggggt cattactgaa cagcaatcta gtatcaatat ctctggttat      720

aatttcagtc ttggtgcagc tgtgaaagcg ggggcagctc tgctagatgg agggaacatg      780

ctggaatcta tcttgatcaa accgagcaac agtgaggatc tcctaaaagc agtcctcggg      840

gccaagaaga aactcaacat gtttgtctca gatcaagttg gagatagaaa tccctatgaa      900

aacatccttt ataaagtctg tctttcaggt gaaggatggc catacatagc ctgtagaacg      960

tcagttgtgg ggagagcatg ggagaacaca acaattgatc tcacaaatga aaaacttgtt     1020

gccaactcat ctaggccagt gcctggagca gcaggcccac ctcaggtggg cttgagttac     1080

agtcagacaa tgctgttgaa agacttgatg ggagggattg atcccaatgc tcccacatgg     1140

attgacattg agggcaggtt caatgatcca gtggagatag caatattcca accacaaaat     1200

gggcaattca tacattttta cagggaacct acggaccaga agcaattcaa gcaggactca     1260

aagtattcac acggcatgga tcttgctgat ctcttcaatg cacagcctgg gctgacctca     1320

tcagttatag gtgctctccc acaagggatg gttttgagct gtcaaggttc tgatgacatc     1380

agaaagcttc tggactcaca aaatagaagg gacataaaac tcattgatgt tgagatgacc     1440

aaggaggcct caagagaata tgaagataaa gtgtgggaca aatatggctg gctatgcaaa     1500

atgcacactg gggtagtgag agacaaaaag aagaaagaga tcaccccaca ctgtgcactc     1560

atggactgca tcatttttga gagtgcttcc aaggcaagac tccctgatct aaaaaccgtt     1620

cacaacatcc tgccacatga tttaatcttc agaggaccca atgttgtgac actctaa        1677


<210>  44
<211>  558
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-1)

<400>  44

Met Ser Leu Ser Lys Glu Val Lys Ser Phe Gln Trp Thr Gln Ala Leu 
1               5                   10                  15      


Arg Arg Glu Leu Gln Ser Phe Thr Ser Asp Val Lys Ala Ala Val Ile 
            20                  25                  30          


Lys Asp Ala Thr Ser Leu Leu Asn Gly Leu Asp Phe Ser Glu Val Ser 
        35                  40                  45              


Asn Val Gln Arg Ile Met Arg Lys Glu Arg Arg Asp Asp Lys Asp Leu 
    50                  55                  60                  


Gln Arg Leu Arg Ser Leu Asn Gln Thr Val His Ser Leu Val Asp Leu 
65                  70                  75                  80  


Lys Ser Thr Ser Lys Lys Asn Val Leu Lys Val Gly Arg Leu Ser Ala 
                85                  90                  95      


Glu Glu Leu Met Thr Leu Ala Ala Asp Leu Glu Lys Leu Lys Ala Lys 
            100                 105                 110         


Ile Met Arg Thr Glu Arg Pro Gln Ala Ser Gly Val Tyr Met Gly Asn 
        115                 120                 125             


Leu Thr Ala Gln Gln Leu Asp Gln Arg Ser Gln Ile Leu Gln Met Val 
    130                 135                 140                 


Gly Met Arg Arg Pro Gln Gln Gly Ala Ser Gly Val Val Arg Val Trp 
145                 150                 155                 160 


Asp Val Lys Asp Ser Ser Leu Leu Asn Asn Gln Phe Gly Thr Met Pro 
                165                 170                 175     


Ser Leu Thr Met Ala Cys Met Ala Lys Gln Ser Gln Thr Pro Leu Asn 
            180                 185                 190         


Asp Val Val Gln Ala Leu Thr Asp Leu Gly Leu Leu Tyr Thr Val Lys 
        195                 200                 205             


Tyr Pro Asn Leu Ser Asp Leu Glu Arg Leu Lys Asp Lys His Pro Val 
    210                 215                 220                 


Leu Gly Val Ile Thr Glu Gln Gln Ser Ser Ile Asn Ile Ser Gly Tyr 
225                 230                 235                 240 


Asn Phe Ser Leu Gly Ala Ala Val Lys Ala Gly Ala Ala Leu Leu Asp 
                245                 250                 255     


Gly Gly Asn Met Leu Glu Ser Ile Leu Ile Lys Pro Ser Asn Ser Glu 
            260                 265                 270         


Asp Leu Leu Lys Ala Val Leu Gly Ala Lys Lys Lys Leu Asn Met Phe 
        275                 280                 285             


Val Ser Asp Gln Val Gly Asp Arg Asn Pro Tyr Glu Asn Ile Leu Tyr 
    290                 295                 300                 


Lys Val Cys Leu Ser Gly Glu Gly Trp Pro Tyr Ile Ala Cys Arg Thr 
305                 310                 315                 320 


Ser Val Val Gly Arg Ala Trp Glu Asn Thr Thr Ile Asp Leu Thr Asn 
                325                 330                 335     


Glu Lys Leu Val Ala Asn Ser Ser Arg Pro Val Pro Gly Ala Ala Gly 
            340                 345                 350         


Pro Pro Gln Val Gly Leu Ser Tyr Ser Gln Thr Met Leu Leu Lys Asp 
        355                 360                 365             


Leu Met Gly Gly Ile Asp Pro Asn Ala Pro Thr Trp Ile Asp Ile Glu 
    370                 375                 380                 


Gly Arg Phe Asn Asp Pro Val Glu Ile Ala Ile Phe Gln Pro Gln Asn 
385                 390                 395                 400 


Gly Gln Phe Ile His Phe Tyr Arg Glu Pro Thr Asp Gln Lys Gln Phe 
                405                 410                 415     


Lys Gln Asp Ser Lys Tyr Ser His Gly Met Asp Leu Ala Asp Leu Phe 
            420                 425                 430         


Asn Ala Gln Pro Gly Leu Thr Ser Ser Val Ile Gly Ala Leu Pro Gln 
        435                 440                 445             


Gly Met Val Leu Ser Cys Gln Gly Ser Asp Asp Ile Arg Lys Leu Leu 
    450                 455                 460                 


Asp Ser Gln Asn Arg Arg Asp Ile Lys Leu Ile Asp Val Glu Met Thr 
465                 470                 475                 480 


Lys Glu Ala Ser Arg Glu Tyr Glu Asp Lys Val Trp Asp Lys Tyr Gly 
                485                 490                 495     


Trp Leu Cys Lys Met His Thr Gly Val Val Arg Asp Lys Lys Lys Lys 
            500                 505                 510         


Glu Ile Thr Pro His Cys Ala Leu Met Asp Cys Ile Ile Phe Glu Ser 
        515                 520                 525             


Ala Ser Lys Ala Arg Leu Pro Asp Leu Lys Thr Val His Asn Ile Leu 
    530                 535                 540                 


Pro His Asp Leu Ile Phe Arg Gly Pro Asn Val Val Thr Leu 
545                 550                 555             


<210>  45
<211>  273
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-1)

<400>  45
atgggccaag gcaagtccaa agaagaaagg gacaccagca atacaggcag agcagagctt       60

ttgccagaca ccacctatct tggtcctcta aattgtaaat catgttggca gaaatttgac      120

agcttggtta gatgccatga ccactatctt tgcagacact gtctgaatct cctgctgtca      180

gtttccgaca gatgtcctct ctgtaagtat ccactgccaa ccaaactgaa ggtgtcaaca      240

gtcccaagct ccccacctcc ctatgaggag tga                                   273


<210>  46
<211>  90
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-1)

<400>  46

Met Gly Gln Gly Lys Ser Lys Glu Glu Arg Asp Thr Ser Asn Thr Gly 
1               5                   10                  15      


Arg Ala Glu Leu Leu Pro Asp Thr Thr Tyr Leu Gly Pro Leu Asn Cys 
            20                  25                  30          


Lys Ser Cys Trp Gln Lys Phe Asp Ser Leu Val Arg Cys His Asp His 
        35                  40                  45              


Tyr Leu Cys Arg His Cys Leu Asn Leu Leu Leu Ser Val Ser Asp Arg 
    50                  55                  60                  


Cys Pro Leu Cys Lys Tyr Pro Leu Pro Thr Lys Leu Lys Val Ser Thr 
65                  70                  75                  80  


Val Pro Ser Ser Pro Pro Pro Tyr Glu Glu 
                85                  90  


<210>  47
<211>  6630
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-1)

<400>  47
atggatgaaa ctattgcaga tttgagagag ttgtgtctaa attacataga acaggacgag       60

aggctgtcaa ggcaaaaact caacttcctg ggacaaagag aacccagaat ggtgctaatt      120

gagggactca aattgttatc acgctgtata gagatagaca gtgcagacaa aagtggttgc      180

atacacaacc acgatgacaa atctgttgaa acaatcctaa tagactctgg gattgtgtgt      240

ccaggactgc cactcatcat ccctgatggt tataagttga ttgacaattc ccttattctt      300

cttgaatgtt ttgttagaag cacaccagct agttttgaaa agaagttcat tgaggacacc      360

aacaaactag catgcatcaa agaagatctt gctgttgcag gcatcacact ggttccaata      420

gtggatggtc gttgtgatta tgataacagt ttcatgccag aatgggtgaa ttttaagttc      480

agagacctcc tatttaaact cctggagtat tctagtcaag atgagaaagt ttttgaggag      540

tctgaatact tcaggctctg tgagtctctt aagaccactg ttgacaaacg ttccggcatg      600

gactcaatga aaattttgaa agacgcaaga tcatttcata acgatgagat tatgaaaatg      660

tgccacgatg gtgtcaaccc caacatgagt tgcgatgatg tggtctttgg cataaattcc      720

ttttttggca ggtttaggag ggacctgtta aatgggagac tcaaaaggaa tttccaaaag      780

gtcagccctg ggggcttaat caaggaattc tctgaacttt atgaaaccct tactgataat      840

gatgacatat taatgttgag caaagaggca gttgaatcct gccccttaat gaggttcatt      900

acagcagaga cccatgggca tgagagagga agcgatgcta acactgagta tgaaaggcta      960

ctctctatgt tgaacaaggt gaaaagttta aaattattaa acactagaag gagacagctg     1020

ctgaacttag atgtcttatg tctttcttca cttattaagc agtcaatttc caaagggttg     1080

gaaaatgata aacattgggt tggttgttgc tacagtagtg tgaatgatag gcttgtgagc     1140

cttcaaagta ccaaagaaga attcatgaga cttttgaaga acagaagaaa atcaagagtg     1200

cacaaaaagg catctcttga tgagcttttt agggtatcca taaatgagtt catagcaaaa     1260

atccagaaat gcctatcaac agtgggactt agttttgagc attacggact atcagaatgc     1320

ctcgtgcaag aatgccatat accatttgct gaatttgaga actttatgag agccgggact     1380

catcctgtaa tgcattacac aaaatttgaa gattacactt tccagcctaa catagagcaa     1440

ttgaggggtt tacagagttt gagaaaactg tcatctgttt gtttggctct aacaaacagc     1500

atgaaaacaa gctcagttgc aaggttgaga cagaaccaac tggggtctgt gagatatcaa     1560

gtggtggagt gcaaagaggt gttttgccag ataataaaac tggattccga agagtatcat     1620

ctactatatc agaaaactgg agaatcatcg aggtgttatt ccatacaagg tccggatggt     1680

cacttgattt ccttttacgc agatccaaaa aggttctttt taccaatttt ttcagatgag     1740

gtgttgcaca acatgataga cacaatgatt tcatggatta ggtcatgccc tgacttaaaa     1800

gattctctta ttgacattga gactgcacta aggacattga tcctactgat gctcaccaac     1860

ccaacaaaga gaaatcaaaa gcaggttcaa aatattaggt atttagtgat ggccatcgtc     1920

tcagactttt catcgacctc attaatggat aagttgaagg aggatctaat cacacctgcc     1980

gagaaagtgg tgtacaggct gcttcggttt ttgattagga caatttttgg tactggtgaa     2040

aaggtgttat tgagtgcaaa attcaagttt atgttgaatg tgtcatacct gtgtcatttg     2100

atcacaaagg agacccctga tagattgaca gatcagataa aatgttttga aaagttcttt     2160

gagcccaaga gtgagtttgg tttctttgtc aaccctaagg aaacaatcac acccgaagag     2220

gaatgtgttt tttatgaaca aatgaagaag ttcaccggta aagatattga ttgtcagcat     2280

tcaacccctg gtgttaattt agagatcttt agcatgatgg tatcttcatt caacaatggc     2340

accttaattc taaaagggga gaaaaggctc aacaatctgg accccatgac caactctgga     2400

tgtgcgacag cattagatct cgcaagcaac aaaagtgtgg ttgtcaataa acatctgaat     2460

ggagaacggc ttttggagta tgattttaac aaattgcttg ttagtgctgt gagccaaatt     2520

acagagggct tcatgaggaa acaaaagtat aagctgagac actcagatta cgaatataag     2580

gtctcaaagc ttgtctctag attagtcatc ggttctagga aaacagaagt agacaaattg     2640

gaagatgatc cggtagatgt gtgtttcgag ggggaggagg agacaagttt tttcaggagt     2700

ttagaagata aggtcagctc cacaataaca cggtataata gaggcactag gcttaatgaa     2760

gggcaagggg agggagaatt caagaacaca aaaggactac accaccttca gattattttg     2820

tcaggtaaaa gagcttatct gaggaaagtc attttatcag aaatttcatt tcatctagta     2880

gaggactttg atccatcctg tctcaccaat gacgacatga ggtttatttg tgaggctgtt     2940

gaaggttcaa cagaactgtc accattgtat tttacatcag ctgtcaaaga acaatgtggt     3000

ctggatgaga tggcaagaaa cctctgtaga aagttcttct cagagggtga ttggttctca     3060

tgtatgaaga tgatcttgtt acagatgaat gcaaatgcgt attcagggaa gtacagacac     3120

atgcagaggc agagtttaaa ttttaaattt gactgggaca aattggaaga agatgtaaga     3180

attagtgaaa gggaaagcaa ttctgaatct ctaagtaagg ccctttcatt gacaaaatgc     3240

atgagtgctg ctctaaagaa tctgtgtttt tactcagaag aatcaccaac atcatacact     3300

tcagttggcc ctgactctgg gagactaaaa tttgcattgt catacaaaga gcaggttggg     3360

ggaaatagag agctttacat tggggatttg aggacaaaaa tgttcacaag attggtagaa     3420

gattattttg aatccttttc tagtttcttt tcaggatctt gtttaaacaa tgacaaagag     3480

tttgaaaatg caatcttgtc aatgactatc aatgtgagag aagggttgtt aaactacagc     3540

atggatcaca gcaaatgggg accaatgatg tgcccattcc tattcttaat gcttctccaa     3600

aatctcaaac tgggtgatga tcagtacgtg cgttctggga aagatcatgt tagcaccttg     3660

ttgacttggc atatgcataa acttgttgaa gtccctttcc ctgttgtgaa tgcaatgatg     3720

aaatcatatg ttaaatcaaa actcaagctt ctcaaagggt caggaacgac tgttacggag     3780

agaatcttta gagagtattt tgaaatgggg gtggtgccat ctcacatatc tagtctcatt     3840

gacatgggac aggggatcct acacaatgct tctgattttt acggtttaat tagtgaaagg     3900

tttatcaatt attgtattgg tgtcattttt ggagagaggc cagaagccta tacatcaagt     3960

gatgatcaga tcactttatt tgacaagaga ttgagtgact tagttgatag tgacccagaa     4020

gaagtccttg tcttgctgga attccactct cacttaagtg gtttgttgaa caagttcatc     4080

agtccaaaaa gtgtggttgg gcggtttgca gcggaattca aatccagatt ttatgtgtgg     4140

ggggaggagg tccctctcct cacgaaattt gtgtctgcgg cactacacaa tgttaagtgt     4200

aaagaaccgc atcaactttg tgagacaata gatacgattg ctgatcaagc tatagcaaat     4260

ggagttccag tttttttagt aaactgtatc cagaggagga cactggatct cttgaaatat     4320

gctaatttcc ctttagatcc attcttgtta aacactcaca ctgatgtaaa ggattggtta     4380

gatggttcta gaggttatag aatccaaaga ctcattgaag aattgtgtcc cagtgaaaca     4440

aagatcatga gaaaacttgt aagaagacta catcacaaac tcaagaacgg tgaatgtaac     4500

gaggaatttt ttctagacct cttcaacagg gaaatgaaag aggccatcct tcaattggga     4560

gagattcttg gtcttgagga tgatctcaat gagttggcaa gcatcaattg gttgaatctg     4620

aatgaaatgt tcccattgag gatggttctg agacaaaaag tggtttaccc atcagtaatg     4680

acctttcaag aggaaaagat cccctcattg attaaaacac tccaaaataa gctttgtagt     4740

aagttcacaa gaggtgcaca gaagctgttg tcagaggcaa tcaacaaatc agcttttcag     4800

agttgtgtct catccggctt tataggtctc tgtaagactt taggaagtag gtgtgtgaga     4860

aataaaaaca gggaaaatat gtatatcaga aaggtgcttg aagatctgac catggatgaa     4920

catgtcacaa gggttcacaa acaagatggt gtgatgttgt acatttgcga caagcagaga     4980

cacccagagg ctcaccgtga ccacatcaac cttttgaggc cccttctctg ggactacatt     5040

tgcatctcat tgagcaactc ttttgagctg ggtgtttggg ttttagcaga acctgtgaaa     5100

ggaaagaacg agagtaattc ggctgttagg cacttaaatc catgtgatta tgtagcaaga     5160

aaacctgaga gttcgagact actagaggat aaagtgagtt tgaatcatgt aattcaatct     5220

gtgaggcgac tgtaccccaa aatctttgag gatcagttgc tcccattcat gtctgatgtg     5280

agctcaaaaa atatgagatg gagtcccagg attaaattcc ttgacctttg tgtgctgatt     5340

gacatcaact cagagtcttt gtcactcatt tctcatgttg tcaaatggaa gagggacgaa     5400

cattacactg tgctgttttc tgatctcgtc aactctcacc aacggtcaga ctcaagttta     5460

gttgatgaat ttgttgtcag cacaagggat gtctgcaaga actttttgaa gcaagtgtat     5520

ttcgaatcat ttgtacgaga gtttgttgca acagctagga ccttaggtaa cttttcatgg     5580

ttcccccata aggacatgat gccatctgaa gatggcgctg aagcactggg acccttccaa     5640

tcatttattt tgaaagtggt gaacaagaaa atagagaggc ccatgtttag gaatgacttg     5700

cagtttggtt ttggttggtt ctcttatcgt gtgggggatg ttgtgtgtaa tgccgctatg     5760

ttaattaagc agggtttgac agatccaaaa gcatttaaat ctttaagaga tttgtgggat     5820

tacatgctca gcagcacaga ggggatattg gagttctcaa tcacagtgga tttcacacac     5880

aaccagaaca acactgactg cttgaggaaa ttttcattga tctttgtggt taaatgccaa     5940

ttacagagtc caggtgtagc tgattactta tcgtgctctc atttcttcaa aggtgaggtt     6000

gacaggagat tattagatga gtgtctcaat ctgttgagga cagaccccat ctttaaagcg     6060

aatgatggag tctttgacat taggtctgaa gagtttgaag attacatgga agaccctttg     6120

acacttggtg attcactaga acttgaacta ataggttcta gaaggattct gaatgagatc     6180

aaatctactg actttgagag gatagggcct gagtgggaac ctgtgcctct gaccataagg     6240

aagggtgccc tctttgaggg gaggaacttt gttcagaata tctctgtgaa attggagaca     6300

aaggacatga gggtctttct ggcagagctc gagggctgtg gagaaattgg tgatgtcctc     6360

ggcagcctcc tcctgcaccg attcagaact ggtgagcact tgatggagtc agaaataagt     6420

rcagttcttc aggagctctg catggacaga tccgtcatgc tgacaccatt atcttttgtg     6480

ccagattggt tcaccttcag agattgtagg ctctgcttca gcaggtcaaa gaacactgta     6540

atgtatgaga cagctggggg caggttcaga ctcaagggga aatcctgtga cgattggctg     6600

gcggagcggg tggccgagga gatcgactag                                      6630


<210>  48
<211>  2209
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-1)

<400>  48

Met Asp Glu Thr Ile Ala Asp Leu Arg Glu Leu Cys Leu Asn Tyr Ile 
1               5                   10                  15      


Glu Gln Asp Glu Arg Leu Ser Arg Gln Lys Leu Asn Phe Leu Gly Gln 
            20                  25                  30          


Arg Glu Pro Arg Met Val Leu Ile Glu Gly Leu Lys Leu Leu Ser Arg 
        35                  40                  45              


Cys Ile Glu Ile Asp Ser Ala Asp Lys Ser Gly Cys Ile His Asn His 
    50                  55                  60                  


Asp Asp Lys Ser Val Glu Thr Ile Leu Ile Asp Ser Gly Ile Val Cys 
65                  70                  75                  80  


Pro Gly Leu Pro Leu Ile Ile Pro Asp Gly Tyr Lys Leu Ile Asp Asn 
                85                  90                  95      


Ser Leu Ile Leu Leu Glu Cys Phe Val Arg Ser Thr Pro Ala Ser Phe 
            100                 105                 110         


Glu Lys Lys Phe Ile Glu Asp Thr Asn Lys Leu Ala Cys Ile Lys Glu 
        115                 120                 125             


Asp Leu Ala Val Ala Gly Ile Thr Leu Val Pro Ile Val Asp Gly Arg 
    130                 135                 140                 


Cys Asp Tyr Asp Asn Ser Phe Met Pro Glu Trp Val Asn Phe Lys Phe 
145                 150                 155                 160 


Arg Asp Leu Leu Phe Lys Leu Leu Glu Tyr Ser Ser Gln Asp Glu Lys 
                165                 170                 175     


Val Phe Glu Glu Ser Glu Tyr Phe Arg Leu Cys Glu Ser Leu Lys Thr 
            180                 185                 190         


Thr Val Asp Lys Arg Ser Gly Met Asp Ser Met Lys Ile Leu Lys Asp 
        195                 200                 205             


Ala Arg Ser Phe His Asn Asp Glu Ile Met Lys Met Cys His Asp Gly 
    210                 215                 220                 


Val Asn Pro Asn Met Ser Cys Asp Asp Val Val Phe Gly Ile Asn Ser 
225                 230                 235                 240 


Phe Phe Gly Arg Phe Arg Arg Asp Leu Leu Asn Gly Arg Leu Lys Arg 
                245                 250                 255     


Asn Phe Gln Lys Val Ser Pro Gly Gly Leu Ile Lys Glu Phe Ser Glu 
            260                 265                 270         


Leu Tyr Glu Thr Leu Thr Asp Asn Asp Asp Ile Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Ala Val Glu Ser Cys Pro Leu Met Arg Phe Ile Thr Ala Glu Thr 
    290                 295                 300                 


His Gly His Glu Arg Gly Ser Asp Ala Asn Thr Glu Tyr Glu Arg Leu 
305                 310                 315                 320 


Leu Ser Met Leu Asn Lys Val Lys Ser Leu Lys Leu Leu Asn Thr Arg 
                325                 330                 335     


Arg Arg Gln Leu Leu Asn Leu Asp Val Leu Cys Leu Ser Ser Leu Ile 
            340                 345                 350         


Lys Gln Ser Ile Ser Lys Gly Leu Glu Asn Asp Lys His Trp Val Gly 
        355                 360                 365             


Cys Cys Tyr Ser Ser Val Asn Asp Arg Leu Val Ser Leu Gln Ser Thr 
    370                 375                 380                 


Lys Glu Glu Phe Met Arg Leu Leu Lys Asn Arg Arg Lys Ser Arg Val 
385                 390                 395                 400 


His Lys Lys Ala Ser Leu Asp Glu Leu Phe Arg Val Ser Ile Asn Glu 
                405                 410                 415     


Phe Ile Ala Lys Ile Gln Lys Cys Leu Ser Thr Val Gly Leu Ser Phe 
            420                 425                 430         


Glu His Tyr Gly Leu Ser Glu Cys Leu Val Gln Glu Cys His Ile Pro 
        435                 440                 445             


Phe Ala Glu Phe Glu Asn Phe Met Arg Ala Gly Thr His Pro Val Met 
    450                 455                 460                 


His Tyr Thr Lys Phe Glu Asp Tyr Thr Phe Gln Pro Asn Ile Glu Gln 
465                 470                 475                 480 


Leu Arg Gly Leu Gln Ser Leu Arg Lys Leu Ser Ser Val Cys Leu Ala 
                485                 490                 495     


Leu Thr Asn Ser Met Lys Thr Ser Ser Val Ala Arg Leu Arg Gln Asn 
            500                 505                 510         


Gln Leu Gly Ser Val Arg Tyr Gln Val Val Glu Cys Lys Glu Val Phe 
        515                 520                 525             


Cys Gln Ile Ile Lys Leu Asp Ser Glu Glu Tyr His Leu Leu Tyr Gln 
    530                 535                 540                 


Lys Thr Gly Glu Ser Ser Arg Cys Tyr Ser Ile Gln Gly Pro Asp Gly 
545                 550                 555                 560 


His Leu Ile Ser Phe Tyr Ala Asp Pro Lys Arg Phe Phe Leu Pro Ile 
                565                 570                 575     


Phe Ser Asp Glu Val Leu His Asn Met Ile Asp Thr Met Ile Ser Trp 
            580                 585                 590         


Ile Arg Ser Cys Pro Asp Leu Lys Asp Ser Leu Ile Asp Ile Glu Thr 
        595                 600                 605             


Ala Leu Arg Thr Leu Ile Leu Leu Met Leu Thr Asn Pro Thr Lys Arg 
    610                 615                 620                 


Asn Gln Lys Gln Val Gln Asn Ile Arg Tyr Leu Val Met Ala Ile Val 
625                 630                 635                 640 


Ser Asp Phe Ser Ser Thr Ser Leu Met Asp Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Ile Thr Pro Ala Glu Lys Val Val Tyr Arg Leu Leu Arg Phe Leu Ile 
            660                 665                 670         


Arg Thr Ile Phe Gly Thr Gly Glu Lys Val Leu Leu Ser Ala Lys Phe 
        675                 680                 685             


Lys Phe Met Leu Asn Val Ser Tyr Leu Cys His Leu Ile Thr Lys Glu 
    690                 695                 700                 


Thr Pro Asp Arg Leu Thr Asp Gln Ile Lys Cys Phe Glu Lys Phe Phe 
705                 710                 715                 720 


Glu Pro Lys Ser Glu Phe Gly Phe Phe Val Asn Pro Lys Glu Thr Ile 
                725                 730                 735     


Thr Pro Glu Glu Glu Cys Val Phe Tyr Glu Gln Met Lys Lys Phe Thr 
            740                 745                 750         


Gly Lys Asp Ile Asp Cys Gln His Ser Thr Pro Gly Val Asn Leu Glu 
        755                 760                 765             


Ile Phe Ser Met Met Val Ser Ser Phe Asn Asn Gly Thr Leu Ile Leu 
    770                 775                 780                 


Lys Gly Glu Lys Arg Leu Asn Asn Leu Asp Pro Met Thr Asn Ser Gly 
785                 790                 795                 800 


Cys Ala Thr Ala Leu Asp Leu Ala Ser Asn Lys Ser Val Val Val Asn 
                805                 810                 815     


Lys His Leu Asn Gly Glu Arg Leu Leu Glu Tyr Asp Phe Asn Lys Leu 
            820                 825                 830         


Leu Val Ser Ala Val Ser Gln Ile Thr Glu Gly Phe Met Arg Lys Gln 
        835                 840                 845             


Lys Tyr Lys Leu Arg His Ser Asp Tyr Glu Tyr Lys Val Ser Lys Leu 
    850                 855                 860                 


Val Ser Arg Leu Val Ile Gly Ser Arg Lys Thr Glu Val Asp Lys Leu 
865                 870                 875                 880 


Glu Asp Asp Pro Val Asp Val Cys Phe Glu Gly Glu Glu Glu Thr Ser 
                885                 890                 895     


Phe Phe Arg Ser Leu Glu Asp Lys Val Ser Ser Thr Ile Thr Arg Tyr 
            900                 905                 910         


Asn Arg Gly Thr Arg Leu Asn Glu Gly Gln Gly Glu Gly Glu Phe Lys 
        915                 920                 925             


Asn Thr Lys Gly Leu His His Leu Gln Ile Ile Leu Ser Gly Lys Arg 
    930                 935                 940                 


Ala Tyr Leu Arg Lys Val Ile Leu Ser Glu Ile Ser Phe His Leu Val 
945                 950                 955                 960 


Glu Asp Phe Asp Pro Ser Cys Leu Thr Asn Asp Asp Met Arg Phe Ile 
                965                 970                 975     


Cys Glu Ala Val Glu Gly Ser Thr Glu Leu Ser Pro Leu Tyr Phe Thr 
            980                 985                 990         


Ser Ala Val Lys Glu Gln Cys Gly  Leu Asp Glu Met Ala  Arg Asn Leu 
        995                 1000                 1005             


Cys Arg  Lys Phe Phe Ser Glu  Gly Asp Trp Phe Ser  Cys Met Lys 
    1010                 1015                 1020             


Met Ile  Leu Leu Gln Met Asn  Ala Asn Ala Tyr Ser  Gly Lys Tyr 
    1025                 1030                 1035             


Arg His  Met Gln Arg Gln Ser  Leu Asn Phe Lys Phe  Asp Trp Asp 
    1040                 1045                 1050             


Lys Leu  Glu Glu Asp Val Arg  Ile Ser Glu Arg Glu  Ser Asn Ser 
    1055                 1060                 1065             


Glu Ser  Leu Ser Lys Ala Leu  Ser Leu Thr Lys Cys  Met Ser Ala 
    1070                 1075                 1080             


Ala Leu  Lys Asn Leu Cys Phe  Tyr Ser Glu Glu Ser  Pro Thr Ser 
    1085                 1090                 1095             


Tyr Thr  Ser Val Gly Pro Asp  Ser Gly Arg Leu Lys  Phe Ala Leu 
    1100                 1105                 1110             


Ser Tyr  Lys Glu Gln Val Gly  Gly Asn Arg Glu Leu  Tyr Ile Gly 
    1115                 1120                 1125             


Asp Leu  Arg Thr Lys Met Phe  Thr Arg Leu Val Glu  Asp Tyr Phe 
    1130                 1135                 1140             


Glu Ser  Phe Ser Ser Phe Phe  Ser Gly Ser Cys Leu  Asn Asn Asp 
    1145                 1150                 1155             


Lys Glu  Phe Glu Asn Ala Ile  Leu Ser Met Thr Ile  Asn Val Arg 
    1160                 1165                 1170             


Glu Gly  Leu Leu Asn Tyr Ser  Met Asp His Ser Lys  Trp Gly Pro 
    1175                 1180                 1185             


Met Met  Cys Pro Phe Leu Phe  Leu Met Leu Leu Gln  Asn Leu Lys 
    1190                 1195                 1200             


Leu Gly  Asp Asp Gln Tyr Val  Arg Ser Gly Lys Asp  His Val Ser 
    1205                 1210                 1215             


Thr Leu  Leu Thr Trp His Met  His Lys Leu Val Glu  Val Pro Phe 
    1220                 1225                 1230             


Pro Val  Val Asn Ala Met Met  Lys Ser Tyr Val Lys  Ser Lys Leu 
    1235                 1240                 1245             


Lys Leu  Leu Lys Gly Ser Gly  Thr Thr Val Thr Glu  Arg Ile Phe 
    1250                 1255                 1260             


Arg Glu  Tyr Phe Glu Met Gly  Val Val Pro Ser His  Ile Ser Ser 
    1265                 1270                 1275             


Leu Ile  Asp Met Gly Gln Gly  Ile Leu His Asn Ala  Ser Asp Phe 
    1280                 1285                 1290             


Tyr Gly  Leu Ile Ser Glu Arg  Phe Ile Asn Tyr Cys  Ile Gly Val 
    1295                 1300                 1305             


Ile Phe  Gly Glu Arg Pro Glu  Ala Tyr Thr Ser Ser  Asp Asp Gln 
    1310                 1315                 1320             


Ile Thr  Leu Phe Asp Lys Arg  Leu Ser Asp Leu Val  Asp Ser Asp 
    1325                 1330                 1335             


Pro Glu  Glu Val Leu Val Leu  Leu Glu Phe His Ser  His Leu Ser 
    1340                 1345                 1350             


Gly Leu  Leu Asn Lys Phe Ile  Ser Pro Lys Ser Val  Val Gly Arg 
    1355                 1360                 1365             


Phe Ala  Ala Glu Phe Lys Ser  Arg Phe Tyr Val Trp  Gly Glu Glu 
    1370                 1375                 1380             


Val Pro  Leu Leu Thr Lys Phe  Val Ser Ala Ala Leu  His Asn Val 
    1385                 1390                 1395             


Lys Cys  Lys Glu Pro His Gln  Leu Cys Glu Thr Ile  Asp Thr Ile 
    1400                 1405                 1410             


Ala Asp  Gln Ala Ile Ala Asn  Gly Val Pro Val Phe  Leu Val Asn 
    1415                 1420                 1425             


Cys Ile  Gln Arg Arg Thr Leu  Asp Leu Leu Lys Tyr  Ala Asn Phe 
    1430                 1435                 1440             


Pro Leu  Asp Pro Phe Leu Leu  Asn Thr His Thr Asp  Val Lys Asp 
    1445                 1450                 1455             


Trp Leu  Asp Gly Ser Arg Gly  Tyr Arg Ile Gln Arg  Leu Ile Glu 
    1460                 1465                 1470             


Glu Leu  Cys Pro Ser Glu Thr  Lys Ile Met Arg Lys  Leu Val Arg 
    1475                 1480                 1485             


Arg Leu  His His Lys Leu Lys  Asn Gly Glu Cys Asn  Glu Glu Phe 
    1490                 1495                 1500             


Phe Leu  Asp Leu Phe Asn Arg  Glu Met Lys Glu Ala  Ile Leu Gln 
    1505                 1510                 1515             


Leu Gly  Glu Ile Leu Gly Leu  Glu Asp Asp Leu Asn  Glu Leu Ala 
    1520                 1525                 1530             


Ser Ile  Asn Trp Leu Asn Leu  Asn Glu Met Phe Pro  Leu Arg Met 
    1535                 1540                 1545             


Val Leu  Arg Gln Lys Val Val  Tyr Pro Ser Val Met  Thr Phe Gln 
    1550                 1555                 1560             


Glu Glu  Lys Ile Pro Ser Leu  Ile Lys Thr Leu Gln  Asn Lys Leu 
    1565                 1570                 1575             


Cys Ser  Lys Phe Thr Arg Gly  Ala Gln Lys Leu Leu  Ser Glu Ala 
    1580                 1585                 1590             


Ile Asn  Lys Ser Ala Phe Gln  Ser Cys Val Ser Ser  Gly Phe Ile 
    1595                 1600                 1605             


Gly Leu  Cys Lys Thr Leu Gly  Ser Arg Cys Val Arg  Asn Lys Asn 
    1610                 1615                 1620             


Arg Glu  Asn Met Tyr Ile Arg  Lys Val Leu Glu Asp  Leu Thr Met 
    1625                 1630                 1635             


Asp Glu  His Val Thr Arg Val  His Lys Gln Asp Gly  Val Met Leu 
    1640                 1645                 1650             


Tyr Ile  Cys Asp Lys Gln Arg  His Pro Glu Ala His  Arg Asp His 
    1655                 1660                 1665             


Ile Asn  Leu Leu Arg Pro Leu  Leu Trp Asp Tyr Ile  Cys Ile Ser 
    1670                 1675                 1680             


Leu Ser  Asn Ser Phe Glu Leu  Gly Val Trp Val Leu  Ala Glu Pro 
    1685                 1690                 1695             


Val Lys  Gly Lys Asn Glu Ser  Asn Ser Ala Val Arg  His Leu Asn 
    1700                 1705                 1710             


Pro Cys  Asp Tyr Val Ala Arg  Lys Pro Glu Ser Ser  Arg Leu Leu 
    1715                 1720                 1725             


Glu Asp  Lys Val Ser Leu Asn  His Val Ile Gln Ser  Val Arg Arg 
    1730                 1735                 1740             


Leu Tyr  Pro Lys Ile Phe Glu  Asp Gln Leu Leu Pro  Phe Met Ser 
    1745                 1750                 1755             


Asp Val  Ser Ser Lys Asn Met  Arg Trp Ser Pro Arg  Ile Lys Phe 
    1760                 1765                 1770             


Leu Asp  Leu Cys Val Leu Ile  Asp Ile Asn Ser Glu  Ser Leu Ser 
    1775                 1780                 1785             


Leu Ile  Ser His Val Val Lys  Trp Lys Arg Asp Glu  His Tyr Thr 
    1790                 1795                 1800             


Val Leu  Phe Ser Asp Leu Val  Asn Ser His Gln Arg  Ser Asp Ser 
    1805                 1810                 1815             


Ser Leu  Val Asp Glu Phe Val  Val Ser Thr Arg Asp  Val Cys Lys 
    1820                 1825                 1830             


Asn Phe  Leu Lys Gln Val Tyr  Phe Glu Ser Phe Val  Arg Glu Phe 
    1835                 1840                 1845             


Val Ala  Thr Ala Arg Thr Leu  Gly Asn Phe Ser Trp  Phe Pro His 
    1850                 1855                 1860             


Lys Asp  Met Met Pro Ser Glu  Asp Gly Ala Glu Ala  Leu Gly Pro 
    1865                 1870                 1875             


Phe Gln  Ser Phe Ile Leu Lys  Val Val Asn Lys Lys  Ile Glu Arg 
    1880                 1885                 1890             


Pro Met  Phe Arg Asn Asp Leu  Gln Phe Gly Phe Gly  Trp Phe Ser 
    1895                 1900                 1905             


Tyr Arg  Val Gly Asp Val Val  Cys Asn Ala Ala Met  Leu Ile Lys 
    1910                 1915                 1920             


Gln Gly  Leu Thr Asp Pro Lys  Ala Phe Lys Ser Leu  Arg Asp Leu 
    1925                 1930                 1935             


Trp Asp  Tyr Met Leu Ser Ser  Thr Glu Gly Ile Leu  Glu Phe Ser 
    1940                 1945                 1950             


Ile Thr  Val Asp Phe Thr His  Asn Gln Asn Asn Thr  Asp Cys Leu 
    1955                 1960                 1965             


Arg Lys  Phe Ser Leu Ile Phe  Val Val Lys Cys Gln  Leu Gln Ser 
    1970                 1975                 1980             


Pro Gly  Val Ala Asp Tyr Leu  Ser Cys Ser His Phe  Phe Lys Gly 
    1985                 1990                 1995             


Glu Val  Asp Arg Arg Leu Leu  Asp Glu Cys Leu Asn  Leu Leu Arg 
    2000                 2005                 2010             


Thr Asp  Pro Ile Phe Lys Ala  Asn Asp Gly Val Phe  Asp Ile Arg 
    2015                 2020                 2025             


Ser Glu  Glu Phe Glu Asp Tyr  Met Glu Asp Pro Leu  Thr Leu Gly 
    2030                 2035                 2040             


Asp Ser  Leu Glu Leu Glu Leu  Ile Gly Ser Arg Arg  Ile Leu Asn 
    2045                 2050                 2055             


Glu Ile  Lys Ser Thr Asp Phe  Glu Arg Ile Gly Pro  Glu Trp Glu 
    2060                 2065                 2070             


Pro Val  Pro Leu Thr Ile Arg  Lys Gly Ala Leu Phe  Glu Gly Arg 
    2075                 2080                 2085             


Asn Phe  Val Gln Asn Ile Ser  Val Lys Leu Glu Thr  Lys Asp Met 
    2090                 2095                 2100             


Arg Val  Phe Leu Ala Glu Leu  Glu Gly Cys Gly Glu  Ile Gly Asp 
    2105                 2110                 2115             


Val Leu  Gly Ser Leu Leu Leu  His Arg Phe Arg Thr  Gly Glu His 
    2120                 2125                 2130             


Leu Met  Glu Ser Glu Ile Ser  Thr Val Leu Gln Glu  Leu Cys Met 
    2135                 2140                 2145             


Asp Arg  Ser Val Met Leu Thr  Pro Leu Ser Phe Val  Pro Asp Trp 
    2150                 2155                 2160             


Phe Thr  Phe Arg Asp Cys Arg  Leu Cys Phe Ser Arg  Ser Lys Asn 
    2165                 2170                 2175             


Thr Val  Met Tyr Glu Thr Ala  Gly Gly Arg Phe Arg  Leu Lys Gly 
    2180                 2185                 2190             


Lys Ser  Cys Asp Asp Trp Leu  Ala Glu Arg Val Ala  Glu Glu Ile 
    2195                 2200                 2205             


Asp 
    


<210>  49
<211>  1497
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-1.3)

<400>  49
atgggtcaga ttgtgacaat gtttgaggct ttgcctcaca tcattgatga ggtcatcaac       60

attgtcatta ttgtgctcat tataatcacg agcatcaaag ctgtgtacaa tttcgccacc      120

tgtgggatat tagcactggt cagcttcctt tttttggctg gtaggtcctg tggcatgtac      180

ggccttaatg gtcccgacat ctataaaggg gtttaccagt tcaaatcagt ggagtttgat      240

atgtctcact taaatctgac gatgcccaat gcgtgctcag ccaacaactc tcatcactac      300

atcagtatgg gaagctctgg actggagcta actttcacta acgactccat ccttaatcac      360

aatttttgca acttaacctc cgctttcaac aaaaagactt ttgaccatac actcatgagt      420

atagtctcga gtctgcacct cagtattaga gggaattcca accacaaagc agtgtcttgt      480

gattttaaca atggcatcac cattcaatac aacttgtcat tttcggaccc acagagcgct      540

ataagccagt gttggacttt cagaggtaga gtcttggaca tgtttagaac tgcctttgga      600

ggaaaataca tgagaagtgg ctggggctgg gcaggttcag atggcaagac cacttggtgc      660

agccaaacaa gctatcagta cctaatcata caaaacagga cttgggaaaa ccactgtaga      720

tatgcaggcc cttttgggat gtctagaatc ctctttgctc aggaaaagac aaagtttctc      780

actaggagac ttgcaggcac attcacctgg accctgtcag actcctcagg agtagaaaat      840

ccaggtggtt attgcctgac caaatggatg atccttgctg cagagctcaa atgttttggg      900

aacacagctg ttgcaaaatg taatgtcaat catgatgaag agttctgtga catgctacga      960

ctaattgatt acaacaaggc cgccctgagt aagttcaagc aagatgtaga gtctgccttg     1020

catgtattca aaacaacagt aaattctctg atttccgatc agctgttgat gaggaatcat     1080

ctaagagatc taatgggggt accatactgt aattactcaa agttctggta tctggaacat     1140

gctaagactg gtgagactag tgtacccaag tgctggcttg tcactaatgg ctcctacttg     1200

aatgagaccc actttagtga tcaaatcgaa caagaagcag ataacatgat cacagagatg     1260

ttgaggaagg actacataaa aagacaaggg agtactcctt tagccttaat ggatcttttg     1320

atgttttcaa catcagcata tctaatcagc atctttctgc atcttgtgaa gataccaaca     1380

catagacaca taaagggcgg ttcatgtcca aagccacacc gcttgaccaa caaggggatc     1440

tgtagttgtg gtgcattcaa ggtgcctggt gtaaaaacta tctggaaaag acgctga        1497


<210>  50
<211>  498
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-1.3)

<400>  50

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Asn Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Ser Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Leu Asn His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn His Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Ser Phe Ser Asp 
                165                 170                 175     


Pro Gln Ser Ala Ile Ser Gln Cys Trp Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Ala Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Arg 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Phe Ala Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Gln Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Val Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Ile Trp Lys 
                485                 490                 495     


Arg Arg 
        


<210>  51
<211>  1677
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-1.3)

<400>  51
atgtctttgt ccaaagaagt caaaagcttt cagtggacac aggcgttgag gagggagttg       60

cagagtttta catcagatgt aaaggctgcc gtcatcaagg acgcaaccag tcttctaaat      120

gggttggact tttctgaagt cagcaacgtt cagaggatca tgagaaagga aaggagggat      180

gataaagact tgcagagact caggagtctt aaccagactg tgcattctct tgttgatctg      240

aagtctacat caaagaaaaa tgttctgaaa gtgggaagac ttagtgcaga ggaattgatg      300

acccttgcag ctgatctcga gaagctgaag gccaaaatta tgagaactga gaggcctcaa      360

gcttctggag tctacatggg aaatttgaca gcacaacaac ttgatcaaag atcccaaata      420

ctgcaaatgg ttgggatgag aagacctcag cagggtgcaa gtggtgtagt aagggtttgg      480

gatgtgaagg actcatcact tctgaacaat cagttcggca caatgccaag cctgacaatg      540

gcttgcatgg caaaacagtc acagacccca ctcaatgatg ttgtgcaggc actcacagac      600

cttggcttac tttacacagt caaatacccg aatctcagtg atcttgaaag gctaaaggat      660

aaacacccag ttctgggggt cattactgaa cagcaatcta gtatcaatat ctctggttat      720

aatttcagtc ttggtgcagc tgtgaaagcg ggggcagctc tgctagatgg agggaacatg      780

ctggaatcta tcttgatcaa accgagcaac agtgaggatc tcctaaaagc agtcctcggg      840

gccaagaaga aactcaacat gtttgtctca gatcaagttg gagatagaaa tccctatgaa      900

aacatccttt ataaagtctg tctttcaggt gaaggatggc catacatagc ctgtagaacg      960

tcagttgtgg ggagagcatg ggagaacaca acaattgatc tcacaaatga aaaacttgtt     1020

gccaactcat ctaggccagt gcctggagca gcaggcccac ctcaggtggg cttgagttac     1080

agtcagacaa tgctgttgaa agacttgatg ggagggattg atcccaatgc tcccacatgg     1140

attgacattg agggcaggtt caatgatcca gtggagatag caatattcca accacaaaat     1200

gggcaattca tacattttta cagggaacct acggaccaga agcaattcaa gcaggactca     1260

aagtattcac acggcatgga tcttgctgat ctcttcaatg cacagcctgg gctgacctca     1320

tcagttatag gtgctctccc acaagggatg gttttgagct gtcaaggttc tgatgacatc     1380

agaaagcttc tggactcaca aaatagaagg gacataaaac tcattgatgt tgagatgacc     1440

aaggaggcct caagagaata tgaagataaa gtgtgggaca aatatggctg gctatgcaaa     1500

atgcacactg gggtagtgag agacaaaaag aagaaagaga tcaccccaca ctgtgcactc     1560

atggactgca tcatttttga gagtgcttcc aaggcaagac tccctgatct aaaaaccgtt     1620

cacaacatcc tgccacatga tttaatcttc agaggaccca atgttgtgac actctaa        1677


<210>  52
<211>  558
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-1.3)

<400>  52

Met Ser Leu Ser Lys Glu Val Lys Ser Phe Gln Trp Thr Gln Ala Leu 
1               5                   10                  15      


Arg Arg Glu Leu Gln Ser Phe Thr Ser Asp Val Lys Ala Ala Val Ile 
            20                  25                  30          


Lys Asp Ala Thr Ser Leu Leu Asn Gly Leu Asp Phe Ser Glu Val Ser 
        35                  40                  45              


Asn Val Gln Arg Ile Met Arg Lys Glu Arg Arg Asp Asp Lys Asp Leu 
    50                  55                  60                  


Gln Arg Leu Arg Ser Leu Asn Gln Thr Val His Ser Leu Val Asp Leu 
65                  70                  75                  80  


Lys Ser Thr Ser Lys Lys Asn Val Leu Lys Val Gly Arg Leu Ser Ala 
                85                  90                  95      


Glu Glu Leu Met Thr Leu Ala Ala Asp Leu Glu Lys Leu Lys Ala Lys 
            100                 105                 110         


Ile Met Arg Thr Glu Arg Pro Gln Ala Ser Gly Val Tyr Met Gly Asn 
        115                 120                 125             


Leu Thr Ala Gln Gln Leu Asp Gln Arg Ser Gln Ile Leu Gln Met Val 
    130                 135                 140                 


Gly Met Arg Arg Pro Gln Gln Gly Ala Ser Gly Val Val Arg Val Trp 
145                 150                 155                 160 


Asp Val Lys Asp Ser Ser Leu Leu Asn Asn Gln Phe Gly Thr Met Pro 
                165                 170                 175     


Ser Leu Thr Met Ala Cys Met Ala Lys Gln Ser Gln Thr Pro Leu Asn 
            180                 185                 190         


Asp Val Val Gln Ala Leu Thr Asp Leu Gly Leu Leu Tyr Thr Val Lys 
        195                 200                 205             


Tyr Pro Asn Leu Ser Asp Leu Glu Arg Leu Lys Asp Lys His Pro Val 
    210                 215                 220                 


Leu Gly Val Ile Thr Glu Gln Gln Ser Ser Ile Asn Ile Ser Gly Tyr 
225                 230                 235                 240 


Asn Phe Ser Leu Gly Ala Ala Val Lys Ala Gly Ala Ala Leu Leu Asp 
                245                 250                 255     


Gly Gly Asn Met Leu Glu Ser Ile Leu Ile Lys Pro Ser Asn Ser Glu 
            260                 265                 270         


Asp Leu Leu Lys Ala Val Leu Gly Ala Lys Lys Lys Leu Asn Met Phe 
        275                 280                 285             


Val Ser Asp Gln Val Gly Asp Arg Asn Pro Tyr Glu Asn Ile Leu Tyr 
    290                 295                 300                 


Lys Val Cys Leu Ser Gly Glu Gly Trp Pro Tyr Ile Ala Cys Arg Thr 
305                 310                 315                 320 


Ser Val Val Gly Arg Ala Trp Glu Asn Thr Thr Ile Asp Leu Thr Asn 
                325                 330                 335     


Glu Lys Leu Val Ala Asn Ser Ser Arg Pro Val Pro Gly Ala Ala Gly 
            340                 345                 350         


Pro Pro Gln Val Gly Leu Ser Tyr Ser Gln Thr Met Leu Leu Lys Asp 
        355                 360                 365             


Leu Met Gly Gly Ile Asp Pro Asn Ala Pro Thr Trp Ile Asp Ile Glu 
    370                 375                 380                 


Gly Arg Phe Asn Asp Pro Val Glu Ile Ala Ile Phe Gln Pro Gln Asn 
385                 390                 395                 400 


Gly Gln Phe Ile His Phe Tyr Arg Glu Pro Thr Asp Gln Lys Gln Phe 
                405                 410                 415     


Lys Gln Asp Ser Lys Tyr Ser His Gly Met Asp Leu Ala Asp Leu Phe 
            420                 425                 430         


Asn Ala Gln Pro Gly Leu Thr Ser Ser Val Ile Gly Ala Leu Pro Gln 
        435                 440                 445             


Gly Met Val Leu Ser Cys Gln Gly Ser Asp Asp Ile Arg Lys Leu Leu 
    450                 455                 460                 


Asp Ser Gln Asn Arg Arg Asp Ile Lys Leu Ile Asp Val Glu Met Thr 
465                 470                 475                 480 


Lys Glu Ala Ser Arg Glu Tyr Glu Asp Lys Val Trp Asp Lys Tyr Gly 
                485                 490                 495     


Trp Leu Cys Lys Met His Thr Gly Val Val Arg Asp Lys Lys Lys Lys 
            500                 505                 510         


Glu Ile Thr Pro His Cys Ala Leu Met Asp Cys Ile Ile Phe Glu Ser 
        515                 520                 525             


Ala Ser Lys Ala Arg Leu Pro Asp Leu Lys Thr Val His Asn Ile Leu 
    530                 535                 540                 


Pro His Asp Leu Ile Phe Arg Gly Pro Asn Val Val Thr Leu 
545                 550                 555             


<210>  53
<211>  273
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-1.3)

<400>  53
atgggccaag gcaagtccaa agaagaaagg gacaccagca atacaggcag agcagagctt       60

ttgccagaca ccacctatct tggtcctcta aattgtaaat catgttggca gaaatttgac      120

agcttggtta gatgccatga ccactatctt tgcagacact gtctgaatct cctgctgtca      180

gtttccgaca gatgtcctct ctgtaagtat ccactgccaa ccaaactgaa ggtgtcaaca      240

gtcccaagct ccccacctcc ctatgaggag tga                                   273


<210>  54
<211>  90
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-1.3)

<400>  54

Met Gly Gln Gly Lys Ser Lys Glu Glu Arg Asp Thr Ser Asn Thr Gly 
1               5                   10                  15      


Arg Ala Glu Leu Leu Pro Asp Thr Thr Tyr Leu Gly Pro Leu Asn Cys 
            20                  25                  30          


Lys Ser Cys Trp Gln Lys Phe Asp Ser Leu Val Arg Cys His Asp His 
        35                  40                  45              


Tyr Leu Cys Arg His Cys Leu Asn Leu Leu Leu Ser Val Ser Asp Arg 
    50                  55                  60                  


Cys Pro Leu Cys Lys Tyr Pro Leu Pro Thr Lys Leu Lys Val Ser Thr 
65                  70                  75                  80  


Val Pro Ser Ser Pro Pro Pro Tyr Glu Glu 
                85                  90  


<210>  55
<211>  6630
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-1.3)

<400>  55
atggatgaaa ctattgcaga tttgagagag ttgtgtctaa attacataga acaggacgag       60

aggctgtcaa ggcaaaaact caacttcctg ggacaaagag aacccagaat ggtgctaatt      120

gagggactca aattgttatc acgctgtata gagatagaca gtgcagacaa aagtggttgc      180

atacacaacc acgatgacaa atctgttgaa acaatcctaa tagactctgg gattgtgtgt      240

ccaggactgc cactcatcat ccctgatggt tataagttga ttgacaattc ccttattctt      300

cttgaatgtt ttgttagaag cacaccagct agttttgaaa agaagttcat tgaggacacc      360

aacaaactag catgcatcaa agaagatctt gctgttgcag gcatcacact ggttccaata      420

gtggatggtc gttgtgatta tgataacagt ttcatgccag aatgggtgaa ttttaagttc      480

agagacctcc tatttaaact cctggagtat tctagtcaag atgagaaagt ttttgaggag      540

tctgaatact tcaggctctg tgagtctctt aagaccactg ttgacaaacg ttccggcatg      600

gactcaatga aaattttgaa agacgcaaga tcatttcata acgatgagat tatgaaaatg      660

tgccacgatg gtgtcaaccc caacatgagt tgcgatgatg tggtctttgg cataaattcc      720

ttttttggca ggtttaggag ggacctgtta aatgggaaac tcaaaaggaa tttccaaaag      780

gtcagccctg ggggcttaat caaggaattc tctgaacttt atgaaaccct tactgataat      840

gatgacatat taatgttgag caaagaggca gttgaatcct gccccttaat gaggttcatt      900

acagcagaga cccatgggca tgagagagga agcgatgcta acactgagta tgaaaggcta      960

ctctctatgt taaacaaggt gaaaagttta aaattattaa acactagaag gagacagctg     1020

ctgaacttag atgtcttatg tctttcttca cttattaagc agtcaatttc caaagggttg     1080

gaaaatgata aacattgggt tggttgttgc tacagtagtg tgaatgatag gcttgtgagc     1140

cttcaaagta ccaaagaaga attcatgaga cttttgaaga acagaagaaa atcaagagtg     1200

cacaaaaagg catctcttga tgagcttttt agggtatcca taaatgagtt catagcaaaa     1260

atccagaaat gcctatcaac agtgggactt agttttgagc attacggact atcagaatgc     1320

ctcgtgcaag aatgccatat accatttgct gaatttgaga actttatgag agccgggact     1380

catcctgtaa tgcattacac aaaatttgaa gattacactt tccagcctaa catagagcaa     1440

ttgaggggtt tacagagttt gagaaaactg tcatctgttt gtttggctct aacaaacagc     1500

atgaaaacaa gctcagttgc aaggttgaga cagaaccaac tggggtctgt gagatatcaa     1560

gtggtggagt gcaaagaggt gttttgccag ataataaaac tggattccga agagtatcat     1620

ctactatatc agaaaactgg agaatcatcg aggtgttatt ccatacaagg tccggatggt     1680

cacttgattt ccttttacgc agatccaaaa aggttctttt taccaatttt ttcagatgag     1740

gtgttgcaca acatgataga cacaatgatt tcatggatta ggtcatgccc tgacttaaaa     1800

gattctctta ttgacattga gactgcacta aggacattga tcctactgat gctcaccaac     1860

ccaacaaaga gaaatcaaaa gcaggttcaa aatattaggt atttagtgat ggccatcgtc     1920

tcagactttt catcgacctc attaatggat aagttgaagg aggatctaat cacacctgcc     1980

gagaaagtgg tgtacaggct gcttcggttt ttgattagga caatttttgg tactggtgaa     2040

aaggtgttat tgagtgcaaa attcaagttt atgttgaatg tgtcatacct gtgtcatttg     2100

atcacaaagg agacccctga tagattgaca gatcagataa aatgttttga aaagttcttt     2160

gagcccaaga gtgagtttgg tttctttgtc aaccctaagg aaacaatcac acccgaagag     2220

gaatgtgttt tttatgaaca aatgaagaag ttcaccggta aagatattga ttgtcagcat     2280

tcaacccctg gtgttaattt agagatcttt agcatgatgg tatcttcatt caacaatggc     2340

accttaattc taaaagggga gaaaaggctc aacaatctgg accccatgac caactctgga     2400

tgtgcgacag cattagatct cgcaagcaac aaaagtgtgg ttgtcaataa acatctgaat     2460

ggagaacggc ttttggagta tgattttaac aaattgcttg ttagtgctgt gagccaaatt     2520

acagagggct tcatgaggaa acaaaagtat aagctgagac actcagatta cgaatataag     2580

gtctcaaagc ttgtctctag attagtcatc ggttccagga aaacagaagt agacaaatta     2640

gaagatgatc cggtagatgt gtgtttcgag ggggaggagg agacaagttt tttcaggagt     2700

ttagaagata aggtcagctc cacaataaca cggtataata gaggcactag gcttaatgaa     2760

gggcaagggg agggagaatt caagaacaca aaaggactac accaccttca gattattttg     2820

tcaggtaaaa gagcttatct gaggaaagtc attttatcag aaatttcatt tcatctagta     2880

gaggactttg atccatcctg tctcaccaat gacgacatga ggtttatttg tgaggctgtt     2940

gaaggttcaa cagaactgtc accattgtat tttacatcag ctgtcaaaga acaatgtggt     3000

ctggatgaga tggcaagaaa cctctgtaga aagttcttct cagagggtga ttggttctca     3060

tgtatgaaga tgatcttgtt acagatgaat gcaaatgcgt attcagggaa gtacagacac     3120

atgcagaggc agagcttaaa ttttaaattt gactgggaca aattggaaga agatgtaaga     3180

attagtgaaa gggaaagcaa ttctgaatct ctaagtaagg ccctttcatt gacaaaatgc     3240

atgagtgctg ctctaaagaa tctgtgtttt tactcagaag aatcaccaac atcatacact     3300

tcagttggcc ctgactctgg gagactaaaa tttgcattgt catacaaaga gcaggttggg     3360

ggaaatagag agctttacat tggggatttg aggacaaaaa tgttcacaag attggtagaa     3420

gattactttg aatccttttc tagtttcttt tcaggatctt gtttaaacaa tgacaaagag     3480

tttgaaaatg caatcttgtc aatgactatc aatgtgagag aagggttgtt aaactacagc     3540

atggatcaca gcaaatgggg accaatgatg tgcccattcc tattcttaat gcttctccaa     3600

aatctcaaac tgggtgatga tcagtacgtg cgttctggaa aagatcatgt tagcaccttg     3660

ttgacttggc atatgcataa acttgttgaa gtccctttcc ctgttgtgaa tgcaatgatg     3720

aaatcatatg ttaaatcaaa actcaagctt ctcaaagggt caggaacgac tgttacggag     3780

agaatcttta gagagtattt tgaaatgggg gtggtgccat ctcacatatc tagtctcatt     3840

gacatgggac aggggatcct acacaatgct tctgattttt acggtttaat tagtgaaagg     3900

tttatcaatt attgtattgg tgtcattttt ggagagaggc cagaagccta tacatcaagt     3960

gatgatcaga tcactttatt tgacaagaga ttgagtgact tagttgatag tgacccagaa     4020

gaagtccttg tcttgctgga attccactct cacttaagtg gtttgttgaa caagttcatc     4080

agtccaaaaa gtgtggttgg gcggtttgca gcggaattca aatccagatt ttatgtgtgg     4140

ggggaggagg tccctctcct cacgaaattt gtgtctgcgg cactacacaa tgttaagtgt     4200

aaagaaccgc atcaactttg tgagacaata gatacgattg ctgatcaagc tatagcaaat     4260

ggagttccag tttttttagt aaactgtatc cagaggagga cactggatct cttgaaatat     4320

gctaatttcc ctttagatcc attcttgtta aacactcaca ctgatgtaaa ggattggtta     4380

gatggttcta gaggttatag aatccaaaga ctcattgaag aattgtgtcc cagtgaaaca     4440

aagatcatga gaaaacttgt aagaagacta catcacaaac tcaagaacgg tgaatgtaac     4500

gaggaatttt ttctagacct cttcaacagg gaaaagaaag aggccatcct tcaattggga     4560

gagattcttg gtcttgagga tgatcttaat gagttggcaa gcatcaattg gttgaatctg     4620

aatgaaatgt tcccattgag gatggttctg agacaaaaag tggtttaccc atcagtaatg     4680

acctttcaag aggaaaagat cccctcattg attaaaacac tccaaaataa gctttgtagt     4740

aagttcacaa gaggtgcaca gaagctgttg tcagaggcaa tcaacaaatc agcttttcag     4800

agttgtgtct catccggctt tataggtctc tgtaagactt taggaagtag gtgtgtgaga     4860

aataaaaaca gggaaaatat gtatatcaga aaggtgcttg aagatctgac catggatgaa     4920

catgtcacaa gggttcacaa acaagatggt gtgatgttgt acatttgcga caagcagaga     4980

cacccagagg ctcaccgtga ccacatcaac cttttgaggc cccttctctg ggactacatt     5040

tgcatctcat tgagcaactc ttttgagctg ggtgtttggg ttttagcaga acctgtgaaa     5100

ggaaagaacg agagtaattc ggctgttagg cacttaaatc catgtgatta tgtagcaaga     5160

aaacctgaga gttcgagact actagaggat aaagtgagtt tgaatcatgt aattcaatct     5220

gtgaggcgac tgtaccccaa aatctttgag gatcagttgc tcccattcat gtctgatgtg     5280

agctcaaaaa atatgagatg gagtcccagg attaaattcc ttgacctttg tgtgctgatt     5340

gacatcaact cagagtcttt gtcactcatt tctcatgttg tcaaatggaa gagggacgaa     5400

cattacactg tgctgttttc tgatctcgtc aactctcacc aacggtcaga ctcaagttta     5460

gttgatgaat ttgttgtcag cacaagggat gtctgcaaga actttttgaa gcaagtgtat     5520

ttcgaatcat ttgtacgaga gtttgttgca acagctagga ccttaggtaa cttttcatgg     5580

ttcccccata aggacatgat gccatctgaa gatggcgctg aagcactggg acccttccaa     5640

tcatttattt tgaaagtggt gaacaagaaa atagagaggc ccatgtttag gaatgacttg     5700

cagtttggtt ttggttggtt ctcttatcgt gtgggggatg ttgtgtgtaa tgccgctatg     5760

ttaattaagc agggtttgac agatccaaaa gcatttaaat ctttaagaga tttgtgggat     5820

tacatgctca gcagcacaga ggggatattg gagttctcaa tcacagtgga tttcacacac     5880

aaccagaaca acactgactg cttgaggaaa ttttcattga tctttgtggt taaatgccaa     5940

ttacagagtc caggtgtagc tgattactta tcgtgctctc attccttcaa aggtgaggtt     6000

gacaggagat tattagatga gtgtctcaat ctgttgagga cagaccccat ctttaaagcg     6060

aatgatggag tctttgacat taggtctgaa gagtttgaag attacatgga agaccctttg     6120

acacttggtg attcactaga acttgaacta ataggttcta gaaggattct gaatgagatc     6180

aaatctactg actttgagag gatagggcct gagtgggaac ctgtgcctct gaccataagg     6240

aagggtgccc tctttgaggg gaggaacttt gttcagaata tctctgtgaa attggagaca     6300

aaggacatga gggtctttct ggcagagctc gagggctgtg gaaaaattgg tgatgtcctc     6360

ggcagcctcc tcctgcaccg attcagaact ggtgagcact tgatggagtc agaaataagt     6420

acagttcttc aggagctctg catggacaga tccgtcatgc tgacaccatt atcttttgtg     6480

ccagattggt tcaccttcag agattgtagg ctctgcttca gcaggtcaaa gaacactgta     6540

atgtatgaga caactggggg caggttcaga ctcaagggga aatcctgtga cgattggctg     6600

gcggagcggg tggccgagga gatcgactag                                      6630


<210>  56
<211>  2209
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-1.3)

<400>  56

Met Asp Glu Thr Ile Ala Asp Leu Arg Glu Leu Cys Leu Asn Tyr Ile 
1               5                   10                  15      


Glu Gln Asp Glu Arg Leu Ser Arg Gln Lys Leu Asn Phe Leu Gly Gln 
            20                  25                  30          


Arg Glu Pro Arg Met Val Leu Ile Glu Gly Leu Lys Leu Leu Ser Arg 
        35                  40                  45              


Cys Ile Glu Ile Asp Ser Ala Asp Lys Ser Gly Cys Ile His Asn His 
    50                  55                  60                  


Asp Asp Lys Ser Val Glu Thr Ile Leu Ile Asp Ser Gly Ile Val Cys 
65                  70                  75                  80  


Pro Gly Leu Pro Leu Ile Ile Pro Asp Gly Tyr Lys Leu Ile Asp Asn 
                85                  90                  95      


Ser Leu Ile Leu Leu Glu Cys Phe Val Arg Ser Thr Pro Ala Ser Phe 
            100                 105                 110         


Glu Lys Lys Phe Ile Glu Asp Thr Asn Lys Leu Ala Cys Ile Lys Glu 
        115                 120                 125             


Asp Leu Ala Val Ala Gly Ile Thr Leu Val Pro Ile Val Asp Gly Arg 
    130                 135                 140                 


Cys Asp Tyr Asp Asn Ser Phe Met Pro Glu Trp Val Asn Phe Lys Phe 
145                 150                 155                 160 


Arg Asp Leu Leu Phe Lys Leu Leu Glu Tyr Ser Ser Gln Asp Glu Lys 
                165                 170                 175     


Val Phe Glu Glu Ser Glu Tyr Phe Arg Leu Cys Glu Ser Leu Lys Thr 
            180                 185                 190         


Thr Val Asp Lys Arg Ser Gly Met Asp Ser Met Lys Ile Leu Lys Asp 
        195                 200                 205             


Ala Arg Ser Phe His Asn Asp Glu Ile Met Lys Met Cys His Asp Gly 
    210                 215                 220                 


Val Asn Pro Asn Met Ser Cys Asp Asp Val Val Phe Gly Ile Asn Ser 
225                 230                 235                 240 


Phe Phe Gly Arg Phe Arg Arg Asp Leu Leu Asn Gly Lys Leu Lys Arg 
                245                 250                 255     


Asn Phe Gln Lys Val Ser Pro Gly Gly Leu Ile Lys Glu Phe Ser Glu 
            260                 265                 270         


Leu Tyr Glu Thr Leu Thr Asp Asn Asp Asp Ile Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Ala Val Glu Ser Cys Pro Leu Met Arg Phe Ile Thr Ala Glu Thr 
    290                 295                 300                 


His Gly His Glu Arg Gly Ser Asp Ala Asn Thr Glu Tyr Glu Arg Leu 
305                 310                 315                 320 


Leu Ser Met Leu Asn Lys Val Lys Ser Leu Lys Leu Leu Asn Thr Arg 
                325                 330                 335     


Arg Arg Gln Leu Leu Asn Leu Asp Val Leu Cys Leu Ser Ser Leu Ile 
            340                 345                 350         


Lys Gln Ser Ile Ser Lys Gly Leu Glu Asn Asp Lys His Trp Val Gly 
        355                 360                 365             


Cys Cys Tyr Ser Ser Val Asn Asp Arg Leu Val Ser Leu Gln Ser Thr 
    370                 375                 380                 


Lys Glu Glu Phe Met Arg Leu Leu Lys Asn Arg Arg Lys Ser Arg Val 
385                 390                 395                 400 


His Lys Lys Ala Ser Leu Asp Glu Leu Phe Arg Val Ser Ile Asn Glu 
                405                 410                 415     


Phe Ile Ala Lys Ile Gln Lys Cys Leu Ser Thr Val Gly Leu Ser Phe 
            420                 425                 430         


Glu His Tyr Gly Leu Ser Glu Cys Leu Val Gln Glu Cys His Ile Pro 
        435                 440                 445             


Phe Ala Glu Phe Glu Asn Phe Met Arg Ala Gly Thr His Pro Val Met 
    450                 455                 460                 


His Tyr Thr Lys Phe Glu Asp Tyr Thr Phe Gln Pro Asn Ile Glu Gln 
465                 470                 475                 480 


Leu Arg Gly Leu Gln Ser Leu Arg Lys Leu Ser Ser Val Cys Leu Ala 
                485                 490                 495     


Leu Thr Asn Ser Met Lys Thr Ser Ser Val Ala Arg Leu Arg Gln Asn 
            500                 505                 510         


Gln Leu Gly Ser Val Arg Tyr Gln Val Val Glu Cys Lys Glu Val Phe 
        515                 520                 525             


Cys Gln Ile Ile Lys Leu Asp Ser Glu Glu Tyr His Leu Leu Tyr Gln 
    530                 535                 540                 


Lys Thr Gly Glu Ser Ser Arg Cys Tyr Ser Ile Gln Gly Pro Asp Gly 
545                 550                 555                 560 


His Leu Ile Ser Phe Tyr Ala Asp Pro Lys Arg Phe Phe Leu Pro Ile 
                565                 570                 575     


Phe Ser Asp Glu Val Leu His Asn Met Ile Asp Thr Met Ile Ser Trp 
            580                 585                 590         


Ile Arg Ser Cys Pro Asp Leu Lys Asp Ser Leu Ile Asp Ile Glu Thr 
        595                 600                 605             


Ala Leu Arg Thr Leu Ile Leu Leu Met Leu Thr Asn Pro Thr Lys Arg 
    610                 615                 620                 


Asn Gln Lys Gln Val Gln Asn Ile Arg Tyr Leu Val Met Ala Ile Val 
625                 630                 635                 640 


Ser Asp Phe Ser Ser Thr Ser Leu Met Asp Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Ile Thr Pro Ala Glu Lys Val Val Tyr Arg Leu Leu Arg Phe Leu Ile 
            660                 665                 670         


Arg Thr Ile Phe Gly Thr Gly Glu Lys Val Leu Leu Ser Ala Lys Phe 
        675                 680                 685             


Lys Phe Met Leu Asn Val Ser Tyr Leu Cys His Leu Ile Thr Lys Glu 
    690                 695                 700                 


Thr Pro Asp Arg Leu Thr Asp Gln Ile Lys Cys Phe Glu Lys Phe Phe 
705                 710                 715                 720 


Glu Pro Lys Ser Glu Phe Gly Phe Phe Val Asn Pro Lys Glu Thr Ile 
                725                 730                 735     


Thr Pro Glu Glu Glu Cys Val Phe Tyr Glu Gln Met Lys Lys Phe Thr 
            740                 745                 750         


Gly Lys Asp Ile Asp Cys Gln His Ser Thr Pro Gly Val Asn Leu Glu 
        755                 760                 765             


Ile Phe Ser Met Met Val Ser Ser Phe Asn Asn Gly Thr Leu Ile Leu 
    770                 775                 780                 


Lys Gly Glu Lys Arg Leu Asn Asn Leu Asp Pro Met Thr Asn Ser Gly 
785                 790                 795                 800 


Cys Ala Thr Ala Leu Asp Leu Ala Ser Asn Lys Ser Val Val Val Asn 
                805                 810                 815     


Lys His Leu Asn Gly Glu Arg Leu Leu Glu Tyr Asp Phe Asn Lys Leu 
            820                 825                 830         


Leu Val Ser Ala Val Ser Gln Ile Thr Glu Gly Phe Met Arg Lys Gln 
        835                 840                 845             


Lys Tyr Lys Leu Arg His Ser Asp Tyr Glu Tyr Lys Val Ser Lys Leu 
    850                 855                 860                 


Val Ser Arg Leu Val Ile Gly Ser Arg Lys Thr Glu Val Asp Lys Leu 
865                 870                 875                 880 


Glu Asp Asp Pro Val Asp Val Cys Phe Glu Gly Glu Glu Glu Thr Ser 
                885                 890                 895     


Phe Phe Arg Ser Leu Glu Asp Lys Val Ser Ser Thr Ile Thr Arg Tyr 
            900                 905                 910         


Asn Arg Gly Thr Arg Leu Asn Glu Gly Gln Gly Glu Gly Glu Phe Lys 
        915                 920                 925             


Asn Thr Lys Gly Leu His His Leu Gln Ile Ile Leu Ser Gly Lys Arg 
    930                 935                 940                 


Ala Tyr Leu Arg Lys Val Ile Leu Ser Glu Ile Ser Phe His Leu Val 
945                 950                 955                 960 


Glu Asp Phe Asp Pro Ser Cys Leu Thr Asn Asp Asp Met Arg Phe Ile 
                965                 970                 975     


Cys Glu Ala Val Glu Gly Ser Thr Glu Leu Ser Pro Leu Tyr Phe Thr 
            980                 985                 990         


Ser Ala Val Lys Glu Gln Cys Gly  Leu Asp Glu Met Ala  Arg Asn Leu 
        995                 1000                 1005             


Cys Arg  Lys Phe Phe Ser Glu  Gly Asp Trp Phe Ser  Cys Met Lys 
    1010                 1015                 1020             


Met Ile  Leu Leu Gln Met Asn  Ala Asn Ala Tyr Ser  Gly Lys Tyr 
    1025                 1030                 1035             


Arg His  Met Gln Arg Gln Ser  Leu Asn Phe Lys Phe  Asp Trp Asp 
    1040                 1045                 1050             


Lys Leu  Glu Glu Asp Val Arg  Ile Ser Glu Arg Glu  Ser Asn Ser 
    1055                 1060                 1065             


Glu Ser  Leu Ser Lys Ala Leu  Ser Leu Thr Lys Cys  Met Ser Ala 
    1070                 1075                 1080             


Ala Leu  Lys Asn Leu Cys Phe  Tyr Ser Glu Glu Ser  Pro Thr Ser 
    1085                 1090                 1095             


Tyr Thr  Ser Val Gly Pro Asp  Ser Gly Arg Leu Lys  Phe Ala Leu 
    1100                 1105                 1110             


Ser Tyr  Lys Glu Gln Val Gly  Gly Asn Arg Glu Leu  Tyr Ile Gly 
    1115                 1120                 1125             


Asp Leu  Arg Thr Lys Met Phe  Thr Arg Leu Val Glu  Asp Tyr Phe 
    1130                 1135                 1140             


Glu Ser  Phe Ser Ser Phe Phe  Ser Gly Ser Cys Leu  Asn Asn Asp 
    1145                 1150                 1155             


Lys Glu  Phe Glu Asn Ala Ile  Leu Ser Met Thr Ile  Asn Val Arg 
    1160                 1165                 1170             


Glu Gly  Leu Leu Asn Tyr Ser  Met Asp His Ser Lys  Trp Gly Pro 
    1175                 1180                 1185             


Met Met  Cys Pro Phe Leu Phe  Leu Met Leu Leu Gln  Asn Leu Lys 
    1190                 1195                 1200             


Leu Gly  Asp Asp Gln Tyr Val  Arg Ser Gly Lys Asp  His Val Ser 
    1205                 1210                 1215             


Thr Leu  Leu Thr Trp His Met  His Lys Leu Val Glu  Val Pro Phe 
    1220                 1225                 1230             


Pro Val  Val Asn Ala Met Met  Lys Ser Tyr Val Lys  Ser Lys Leu 
    1235                 1240                 1245             


Lys Leu  Leu Lys Gly Ser Gly  Thr Thr Val Thr Glu  Arg Ile Phe 
    1250                 1255                 1260             


Arg Glu  Tyr Phe Glu Met Gly  Val Val Pro Ser His  Ile Ser Ser 
    1265                 1270                 1275             


Leu Ile  Asp Met Gly Gln Gly  Ile Leu His Asn Ala  Ser Asp Phe 
    1280                 1285                 1290             


Tyr Gly  Leu Ile Ser Glu Arg  Phe Ile Asn Tyr Cys  Ile Gly Val 
    1295                 1300                 1305             


Ile Phe  Gly Glu Arg Pro Glu  Ala Tyr Thr Ser Ser  Asp Asp Gln 
    1310                 1315                 1320             


Ile Thr  Leu Phe Asp Lys Arg  Leu Ser Asp Leu Val  Asp Ser Asp 
    1325                 1330                 1335             


Pro Glu  Glu Val Leu Val Leu  Leu Glu Phe His Ser  His Leu Ser 
    1340                 1345                 1350             


Gly Leu  Leu Asn Lys Phe Ile  Ser Pro Lys Ser Val  Val Gly Arg 
    1355                 1360                 1365             


Phe Ala  Ala Glu Phe Lys Ser  Arg Phe Tyr Val Trp  Gly Glu Glu 
    1370                 1375                 1380             


Val Pro  Leu Leu Thr Lys Phe  Val Ser Ala Ala Leu  His Asn Val 
    1385                 1390                 1395             


Lys Cys  Lys Glu Pro His Gln  Leu Cys Glu Thr Ile  Asp Thr Ile 
    1400                 1405                 1410             


Ala Asp  Gln Ala Ile Ala Asn  Gly Val Pro Val Phe  Leu Val Asn 
    1415                 1420                 1425             


Cys Ile  Gln Arg Arg Thr Leu  Asp Leu Leu Lys Tyr  Ala Asn Phe 
    1430                 1435                 1440             


Pro Leu  Asp Pro Phe Leu Leu  Asn Thr His Thr Asp  Val Lys Asp 
    1445                 1450                 1455             


Trp Leu  Asp Gly Ser Arg Gly  Tyr Arg Ile Gln Arg  Leu Ile Glu 
    1460                 1465                 1470             


Glu Leu  Cys Pro Ser Glu Thr  Lys Ile Met Arg Lys  Leu Val Arg 
    1475                 1480                 1485             


Arg Leu  His His Lys Leu Lys  Asn Gly Glu Cys Asn  Glu Glu Phe 
    1490                 1495                 1500             


Phe Leu  Asp Leu Phe Asn Arg  Glu Lys Lys Glu Ala  Ile Leu Gln 
    1505                 1510                 1515             


Leu Gly  Glu Ile Leu Gly Leu  Glu Asp Asp Leu Asn  Glu Leu Ala 
    1520                 1525                 1530             


Ser Ile  Asn Trp Leu Asn Leu  Asn Glu Met Phe Pro  Leu Arg Met 
    1535                 1540                 1545             


Val Leu  Arg Gln Lys Val Val  Tyr Pro Ser Val Met  Thr Phe Gln 
    1550                 1555                 1560             


Glu Glu  Lys Ile Pro Ser Leu  Ile Lys Thr Leu Gln  Asn Lys Leu 
    1565                 1570                 1575             


Cys Ser  Lys Phe Thr Arg Gly  Ala Gln Lys Leu Leu  Ser Glu Ala 
    1580                 1585                 1590             


Ile Asn  Lys Ser Ala Phe Gln  Ser Cys Val Ser Ser  Gly Phe Ile 
    1595                 1600                 1605             


Gly Leu  Cys Lys Thr Leu Gly  Ser Arg Cys Val Arg  Asn Lys Asn 
    1610                 1615                 1620             


Arg Glu  Asn Met Tyr Ile Arg  Lys Val Leu Glu Asp  Leu Thr Met 
    1625                 1630                 1635             


Asp Glu  His Val Thr Arg Val  His Lys Gln Asp Gly  Val Met Leu 
    1640                 1645                 1650             


Tyr Ile  Cys Asp Lys Gln Arg  His Pro Glu Ala His  Arg Asp His 
    1655                 1660                 1665             


Ile Asn  Leu Leu Arg Pro Leu  Leu Trp Asp Tyr Ile  Cys Ile Ser 
    1670                 1675                 1680             


Leu Ser  Asn Ser Phe Glu Leu  Gly Val Trp Val Leu  Ala Glu Pro 
    1685                 1690                 1695             


Val Lys  Gly Lys Asn Glu Ser  Asn Ser Ala Val Arg  His Leu Asn 
    1700                 1705                 1710             


Pro Cys  Asp Tyr Val Ala Arg  Lys Pro Glu Ser Ser  Arg Leu Leu 
    1715                 1720                 1725             


Glu Asp  Lys Val Ser Leu Asn  His Val Ile Gln Ser  Val Arg Arg 
    1730                 1735                 1740             


Leu Tyr  Pro Lys Ile Phe Glu  Asp Gln Leu Leu Pro  Phe Met Ser 
    1745                 1750                 1755             


Asp Val  Ser Ser Lys Asn Met  Arg Trp Ser Pro Arg  Ile Lys Phe 
    1760                 1765                 1770             


Leu Asp  Leu Cys Val Leu Ile  Asp Ile Asn Ser Glu  Ser Leu Ser 
    1775                 1780                 1785             


Leu Ile  Ser His Val Val Lys  Trp Lys Arg Asp Glu  His Tyr Thr 
    1790                 1795                 1800             


Val Leu  Phe Ser Asp Leu Val  Asn Ser His Gln Arg  Ser Asp Ser 
    1805                 1810                 1815             


Ser Leu  Val Asp Glu Phe Val  Val Ser Thr Arg Asp  Val Cys Lys 
    1820                 1825                 1830             


Asn Phe  Leu Lys Gln Val Tyr  Phe Glu Ser Phe Val  Arg Glu Phe 
    1835                 1840                 1845             


Val Ala  Thr Ala Arg Thr Leu  Gly Asn Phe Ser Trp  Phe Pro His 
    1850                 1855                 1860             


Lys Asp  Met Met Pro Ser Glu  Asp Gly Ala Glu Ala  Leu Gly Pro 
    1865                 1870                 1875             


Phe Gln  Ser Phe Ile Leu Lys  Val Val Asn Lys Lys  Ile Glu Arg 
    1880                 1885                 1890             


Pro Met  Phe Arg Asn Asp Leu  Gln Phe Gly Phe Gly  Trp Phe Ser 
    1895                 1900                 1905             


Tyr Arg  Val Gly Asp Val Val  Cys Asn Ala Ala Met  Leu Ile Lys 
    1910                 1915                 1920             


Gln Gly  Leu Thr Asp Pro Lys  Ala Phe Lys Ser Leu  Arg Asp Leu 
    1925                 1930                 1935             


Trp Asp  Tyr Met Leu Ser Ser  Thr Glu Gly Ile Leu  Glu Phe Ser 
    1940                 1945                 1950             


Ile Thr  Val Asp Phe Thr His  Asn Gln Asn Asn Thr  Asp Cys Leu 
    1955                 1960                 1965             


Arg Lys  Phe Ser Leu Ile Phe  Val Val Lys Cys Gln  Leu Gln Ser 
    1970                 1975                 1980             


Pro Gly  Val Ala Asp Tyr Leu  Ser Cys Ser His Ser  Phe Lys Gly 
    1985                 1990                 1995             


Glu Val  Asp Arg Arg Leu Leu  Asp Glu Cys Leu Asn  Leu Leu Arg 
    2000                 2005                 2010             


Thr Asp  Pro Ile Phe Lys Ala  Asn Asp Gly Val Phe  Asp Ile Arg 
    2015                 2020                 2025             


Ser Glu  Glu Phe Glu Asp Tyr  Met Glu Asp Pro Leu  Thr Leu Gly 
    2030                 2035                 2040             


Asp Ser  Leu Glu Leu Glu Leu  Ile Gly Ser Arg Arg  Ile Leu Asn 
    2045                 2050                 2055             


Glu Ile  Lys Ser Thr Asp Phe  Glu Arg Ile Gly Pro  Glu Trp Glu 
    2060                 2065                 2070             


Pro Val  Pro Leu Thr Ile Arg  Lys Gly Ala Leu Phe  Glu Gly Arg 
    2075                 2080                 2085             


Asn Phe  Val Gln Asn Ile Ser  Val Lys Leu Glu Thr  Lys Asp Met 
    2090                 2095                 2100             


Arg Val  Phe Leu Ala Glu Leu  Glu Gly Cys Gly Lys  Ile Gly Asp 
    2105                 2110                 2115             


Val Leu  Gly Ser Leu Leu Leu  His Arg Phe Arg Thr  Gly Glu His 
    2120                 2125                 2130             


Leu Met  Glu Ser Glu Ile Ser  Thr Val Leu Gln Glu  Leu Cys Met 
    2135                 2140                 2145             


Asp Arg  Ser Val Met Leu Thr  Pro Leu Ser Phe Val  Pro Asp Trp 
    2150                 2155                 2160             


Phe Thr  Phe Arg Asp Cys Arg  Leu Cys Phe Ser Arg  Ser Lys Asn 
    2165                 2170                 2175             


Thr Val  Met Tyr Glu Thr Thr  Gly Gly Arg Phe Arg  Leu Lys Gly 
    2180                 2185                 2190             


Lys Ser  Cys Asp Asp Trp Leu  Ala Glu Arg Val Ala  Glu Glu Ile 
    2195                 2200                 2205             


Asp 
    


<210>  57
<211>  1497
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-2.1)

<400>  57
atgggtcaga ttgtgacaat gtttgaggct ttgcctcaca tcattgatga ggtcatcaac       60

attgttatta ttgtgctcat tataatcacg agcatcaaag ctgtgtacaa tttcgccacc      120

tgtgggatat tagcactggt cagcttcctt tttttggctg gtaggtcctg tggcatgtac      180

ggccttaatg gtcccgacat ctataaaggg gtttaccagt tcaaatcagt ggagtttgat      240

atgtctcact taaatctgac gatgcccaat gcgtgctcag ccaacaactc tcatcactac      300

atcagtatgg gaagctctgg actggagcta actttcacta acgactccat ccttaatcac      360

aatttttgca acttaacctc cgctttcaac aaaaagactt ttgaccatac actcatgagt      420

atagtctcga gtctgcacct cagtattaga gggaattcca accacaaagc agtgtcttgt      480

gattttaaca atggcatcac cattcaatac aacttgtcat tttcggaccc acagagcgct      540

atgagccagt gtaggacttt cagaggtaga gtcttggaca tgtttagaac tgcctttgga      600

ggaaaataca tgagaagtgg ctggggctgg gcaggttcag atggcaagac cacttggtgc      660

agccaaacaa gctatcagta cctaatcata caaaacagga cttgggaaaa ccactgtaga      720

tatgcaggcc cttttgggat gtctagaatc ctctttgctc aggaaaagac aaagtttctc      780

actaggagac ttgcaggcac attcacctgg accctgtcag actcctcagg agtagaaaat      840

ccaggtggtt attgcctgac caaatggatg atccttgctg cagagctcaa atgttttggg      900

aatacagctg ttgcaaaatg taatgtcaat catgatgaag agttctgtga catgctacga      960

ctaattgatt acaacaaggc cgccctgagt aagttcaagc aagatgtaga gtctgccttg     1020

catgtattca aaacaacagt aaattctctg atttccgatc agctgttgat gaggaatcat     1080

ctaagagatc taatgggggt accatactgt aattactcaa agttctggta tctggaacat     1140

gctaagactg gtgagactag tgtacccaag tgctggcttg tcactaatgg ctcctacttg     1200

aatgagaccc actttagtga tcaaatcgaa caagaagcag ataacatgat cacagagatg     1260

ttgaggaagg actacataaa aagacaaggg agtactcctt tagccttaat ggatcttttg     1320

atgttttcaa catcagcata tctaatcagc atctttctgc atcttgtgaa gataccaaca     1380

catagacaca taaagggcgg ttcatgtcca aagccacacc gcttgaccaa caaggggatc     1440

tgtagttgtg gtgcattcaa ggtgcctggt gtaaaaacta tctggaaaag acgctga        1497


<210>  58
<211>  498
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-2.1)

<400>  58

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Asn Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Ser Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Leu Asn His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn His Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Ser Phe Ser Asp 
                165                 170                 175     


Pro Gln Ser Ala Met Ser Gln Cys Arg Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Ala Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Arg 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Phe Ala Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Gln Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Val Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Ile Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Ile Trp Lys 
                485                 490                 495     


Arg Arg 
        


<210>  59
<211>  1677
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-2.1)

<400>  59
atgtctttgt ccaaagaagt caaaagcttt cagtggacac aggcgttgag gagggagttg       60

cagagtttta catcagatgt aaaggctgcc gtcatcaagg acgcaaccag tcttctaaat      120

gggttggact tttctgaagt cagcaacgtt cagaggatca tgagaaagga aaggagggat      180

gataaagact tgcagagact caggagtctt aaccagactg tgcattctct tgttgatctg      240

aagtctacat caaagaaaaa tgttctgaaa gtgggaagac ttagtgcaga ggaattgatg      300

acccttgcag ctgatcttga gaagctgaag gccaaaatta tgagaactga gaggcctcaa      360

gcttctggag tctacatggg aaatttgaca gcacaacaac ttgatcaaag atcccaaata      420

ctgcaaatgg ttgggatgag aagacctcag cagggtgcaa gtggtgtagt aagggtttgg      480

gatgtgaagg actcatcact tctgaacaat cagttcggca caatgccaag cctgacaatg      540

gcttgcatgg caaaacagtc acagacccca ctcaatgatg ttgtgcaggc actcacagac      600

cttggcttac tttacacagt caaatacccg aatctcagtg atcttgaaag gctaaaggat      660

aaacacccag ttctgggggt cattactgaa cagcaatcta gtatcaatat ctctggttat      720

aatttcagtc ttggtgcagc tgtgaaagcg ggggcagctc tgctagatgg agggaacatg      780

ctggaatcta tcttgatcaa accgagcaac agtgaggatc tcctaaaagc agtcctcggg      840

gccaaaaaga aactcaacat gtttgtctca gatcaagttg gagatagaaa tccctatgaa      900

aacatccttt ataaagtctg tctttcaggt gaaggatggc catacatagc ctgtagaacg      960

tcagttgtgg ggagagcatg ggagaacaca acaattgatc tcacaaatga aaaacttgtt     1020

gccaactcat ctaggccagt gcctggagca gcaggcccac ctcaggtggg cttgagttac     1080

agtcagacaa tgctgttgaa agacttgatg ggagggattg atcccaatgc tcccacatgg     1140

attgacattg agggcaggtt caatgatcca gtggagatag caatattcca accacaaaat     1200

gggcaattca tacattttta cagggaacct acggaccaga agcaattcaa gcaggactca     1260

aagtattcac acggcatgga tcttgctgat ctcttcaatg cacagcctgg gctgacctca     1320

tcagttatag gtgctctccc acaagggatg gttttgagct gtcaaggttc tgatgacatc     1380

agaaagcttc tggactcaca aaatagaagg gacataaaac tcattgatgt tgagatgacc     1440

aaggaggcct caagagaata tgaagataaa gtgtgggaca aatatggctg gctatgcaaa     1500

atgcacactg gggtagtgag agacaaaaag aagaaagaga tcaccccaca ctgtgcactc     1560

atggactgca tcatttttga gagtgcttcc aaggcaagac tccctgatct aaaaaccgtt     1620

cacaacatcc tgccacatga tttaatcttc agaggaccca atgttgtgac actctaa        1677


<210>  60
<211>  558
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-2.1)

<400>  60

Met Ser Leu Ser Lys Glu Val Lys Ser Phe Gln Trp Thr Gln Ala Leu 
1               5                   10                  15      


Arg Arg Glu Leu Gln Ser Phe Thr Ser Asp Val Lys Ala Ala Val Ile 
            20                  25                  30          


Lys Asp Ala Thr Ser Leu Leu Asn Gly Leu Asp Phe Ser Glu Val Ser 
        35                  40                  45              


Asn Val Gln Arg Ile Met Arg Lys Glu Arg Arg Asp Asp Lys Asp Leu 
    50                  55                  60                  


Gln Arg Leu Arg Ser Leu Asn Gln Thr Val His Ser Leu Val Asp Leu 
65                  70                  75                  80  


Lys Ser Thr Ser Lys Lys Asn Val Leu Lys Val Gly Arg Leu Ser Ala 
                85                  90                  95      


Glu Glu Leu Met Thr Leu Ala Ala Asp Leu Glu Lys Leu Lys Ala Lys 
            100                 105                 110         


Ile Met Arg Thr Glu Arg Pro Gln Ala Ser Gly Val Tyr Met Gly Asn 
        115                 120                 125             


Leu Thr Ala Gln Gln Leu Asp Gln Arg Ser Gln Ile Leu Gln Met Val 
    130                 135                 140                 


Gly Met Arg Arg Pro Gln Gln Gly Ala Ser Gly Val Val Arg Val Trp 
145                 150                 155                 160 


Asp Val Lys Asp Ser Ser Leu Leu Asn Asn Gln Phe Gly Thr Met Pro 
                165                 170                 175     


Ser Leu Thr Met Ala Cys Met Ala Lys Gln Ser Gln Thr Pro Leu Asn 
            180                 185                 190         


Asp Val Val Gln Ala Leu Thr Asp Leu Gly Leu Leu Tyr Thr Val Lys 
        195                 200                 205             


Tyr Pro Asn Leu Ser Asp Leu Glu Arg Leu Lys Asp Lys His Pro Val 
    210                 215                 220                 


Leu Gly Val Ile Thr Glu Gln Gln Ser Ser Ile Asn Ile Ser Gly Tyr 
225                 230                 235                 240 


Asn Phe Ser Leu Gly Ala Ala Val Lys Ala Gly Ala Ala Leu Leu Asp 
                245                 250                 255     


Gly Gly Asn Met Leu Glu Ser Ile Leu Ile Lys Pro Ser Asn Ser Glu 
            260                 265                 270         


Asp Leu Leu Lys Ala Val Leu Gly Ala Lys Lys Lys Leu Asn Met Phe 
        275                 280                 285             


Val Ser Asp Gln Val Gly Asp Arg Asn Pro Tyr Glu Asn Ile Leu Tyr 
    290                 295                 300                 


Lys Val Cys Leu Ser Gly Glu Gly Trp Pro Tyr Ile Ala Cys Arg Thr 
305                 310                 315                 320 


Ser Val Val Gly Arg Ala Trp Glu Asn Thr Thr Ile Asp Leu Thr Asn 
                325                 330                 335     


Glu Lys Leu Val Ala Asn Ser Ser Arg Pro Val Pro Gly Ala Ala Gly 
            340                 345                 350         


Pro Pro Gln Val Gly Leu Ser Tyr Ser Gln Thr Met Leu Leu Lys Asp 
        355                 360                 365             


Leu Met Gly Gly Ile Asp Pro Asn Ala Pro Thr Trp Ile Asp Ile Glu 
    370                 375                 380                 


Gly Arg Phe Asn Asp Pro Val Glu Ile Ala Ile Phe Gln Pro Gln Asn 
385                 390                 395                 400 


Gly Gln Phe Ile His Phe Tyr Arg Glu Pro Thr Asp Gln Lys Gln Phe 
                405                 410                 415     


Lys Gln Asp Ser Lys Tyr Ser His Gly Met Asp Leu Ala Asp Leu Phe 
            420                 425                 430         


Asn Ala Gln Pro Gly Leu Thr Ser Ser Val Ile Gly Ala Leu Pro Gln 
        435                 440                 445             


Gly Met Val Leu Ser Cys Gln Gly Ser Asp Asp Ile Arg Lys Leu Leu 
    450                 455                 460                 


Asp Ser Gln Asn Arg Arg Asp Ile Lys Leu Ile Asp Val Glu Met Thr 
465                 470                 475                 480 


Lys Glu Ala Ser Arg Glu Tyr Glu Asp Lys Val Trp Asp Lys Tyr Gly 
                485                 490                 495     


Trp Leu Cys Lys Met His Thr Gly Val Val Arg Asp Lys Lys Lys Lys 
            500                 505                 510         


Glu Ile Thr Pro His Cys Ala Leu Met Asp Cys Ile Ile Phe Glu Ser 
        515                 520                 525             


Ala Ser Lys Ala Arg Leu Pro Asp Leu Lys Thr Val His Asn Ile Leu 
    530                 535                 540                 


Pro His Asp Leu Ile Phe Arg Gly Pro Asn Val Val Thr Leu 
545                 550                 555             


<210>  61
<211>  273
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-2.1)

<400>  61
atgggccaag gcaagtccaa agaagaaagg gacaccagca atacaggcag agcagagctt       60

ttgccagaca ccacctatct tggtcctcta aattgtaaat catgttggca gaaatttgac      120

agcttggtta gatgccatga ccactatctt tgcagacact gtctgaatct cctgctgtca      180

gtttccgaca gatgtcctct ctgtaagtat ccactgccaa ccaaactgaa ggtgtcaaca      240

gtcccaagct ccccacctcc ctatgaggag tga                                   273


<210>  62
<211>  90
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-2.1)

<400>  62

Met Gly Gln Gly Lys Ser Lys Glu Glu Arg Asp Thr Ser Asn Thr Gly 
1               5                   10                  15      


Arg Ala Glu Leu Leu Pro Asp Thr Thr Tyr Leu Gly Pro Leu Asn Cys 
            20                  25                  30          


Lys Ser Cys Trp Gln Lys Phe Asp Ser Leu Val Arg Cys His Asp His 
        35                  40                  45              


Tyr Leu Cys Arg His Cys Leu Asn Leu Leu Leu Ser Val Ser Asp Arg 
    50                  55                  60                  


Cys Pro Leu Cys Lys Tyr Pro Leu Pro Thr Lys Leu Lys Val Ser Thr 
65                  70                  75                  80  


Val Pro Ser Ser Pro Pro Pro Tyr Glu Glu 
                85                  90  


<210>  63
<211>  6630
<212>  DNA
<213>  Lymphocytic choriomeningitis virus (mutant P52-2.1)

<400>  63
atggatgaaa ctattgcaga tttgagagag ttgtgtctaa attacataga acaggacgaa       60

aggctgtcaa ggcaaaaact caacttcctg ggacaaagag aacccagaat ggtgctaatt      120

gagggactca aattgttatc acgctgtata gagatagaca gtgcagacaa aagtggttgc      180

atacacaacc acgatgacaa atctgttgaa acaatcctaa tagactctgg gattgtgtgt      240

ccaggactgc cactcatcat ccctgatggt tataagttga ttgacaattc ccttattctt      300

cttgaatgtt ttgttagaag cacaccagct agttttgaaa agaagttcat tgaggacacc      360

aacaaactag catgcatcaa agaagatctt gctgttgcag gcatcacact ggttccaata      420

gtggatggtc gttgtgatta tgataacagt ttcatgccag aatgggtgaa ttttaagttc      480

agagacctcc tatttaaact cctggagtat tctagtcaag atgagaaagt ttttgaggag      540

tctgaatact tcaggctctg tgagtctctt aagaccactg ttgacaaacg ttccggcatg      600

gactcaatga aaattttgaa agacgcaaga tcatttcata acgatgagat tatgaaaatg      660

tgccacgatg gtgtcaaccc caacatgagt tgcgatgatg tggtctttgg cataaattcc      720

ttttttggca ggtttaggag ggacctgtta aatgggaaac tcaaaaggaa tttccaaaag      780

gtcagccctg ggggcttaat caaggaattc tctgaacttt atgaaaccct tactgataat      840

gatgacatat taatgttgag caaagaggca gttgaatcct gccccttaat gaggttcatt      900

acagcagaga cccatgggca tgagagagga agcgatgcta acactgagta tgaaaggcta      960

ctctctatgt tgaacaaggt gaaaagttta aaattattaa acactagaag gagacagctg     1020

ctgaacttag atgtcttatg tctttcttca cttattaagc agtcaatttc caaagggttg     1080

gaaaatgata aacattgggt tggttgttgc tacagtagtg tgaatgatag gcttgtgagc     1140

cttcaaagta ccaaagaaga attcatgaga cttttgaaga acagaagaaa atcaagagtg     1200

cacaaaaagg catctcttga tgagcttttt agggtatcca taaatgagtt catagcaaaa     1260

atccagaaat gcctatcaac agtgggactt agttttgagc attacggact atcagaatgc     1320

ctcgtgcaag aatgccatat accatttgct gaatttgaga actttatgag agccgggact     1380

catcctgtaa tgcattacac aaaatttgaa gattacactt tccagcctaa catagagcaa     1440

ttgaggggtt tacagagttt gagaaaactg tcatctgttt gtttggctct aacaaacagc     1500

atgaaaacaa gctcagttgc aaggttgaga cagaaccaac tggggtctgt gagatatcaa     1560

gtggtggagt gcaaagaggt gttttgccag ataataaaac tggattccga agagtatcat     1620

ctactatatc agaaaactgg agaatcatcg aggtgttatt ccatacaagg tccggatggt     1680

cacttgattt ccttttacgc agatccaaaa aggttctttt taccaatttt ttcagatgag     1740

gtgttgcaca acatgataga cacaatgatt tcatggatta ggtcatgccc tgacttaaaa     1800

gattctctta ttgacattga gactgcacta aggacattga tcctactgat gctcaccaac     1860

ccaacaaaga gaaatcaaaa gcaggttcaa aatattaggt atttagtgat ggccatcgtc     1920

tcagactttt catcgacctc attaatggat aagttgaagg aggatctaat cacacctgcc     1980

gagaaagtgg tgtacaggct gcttcggttt ttgattagga caatttttgg tactggtgaa     2040

aaggtgttat tgagtgcaaa atttaagttt atgttgaatg tgtcatacct gtgtcatttg     2100

atcacaaagg agacccctga tagattgaca gatcagataa aatgttttga aaagttcttt     2160

gagcccaaga gtgagtttgg tttctttgtc aaccctaagg aaacaatcac acccgaagag     2220

gaatgtgttt tttatgaaca aatgaagaag ttcaccggta aagatattga ttgtcagcat     2280

tcaacccctg gtgttaattt agagatcttt agcatgatgg tatcttcatt caacaatggc     2340

accttaattc taaaagggga gaaaaggctc aacaatctgg accccatgac caactctgga     2400

tgtgcgacag cattagatct cgcaagcaac aaaagtgtgg ttgtcaataa acatctgaat     2460

ggagaacggc ttttggagta tgattttaac aaattgcttg ttagtgctgt gagccaaatt     2520

acagagggct tcatgaggaa acaaaagtat aagctgagac actcagatta cgaatataag     2580

gtctcaaagc ttgtctctag attagtcatc ggttccagga aaacagaagt agacaaattg     2640

gaagatgatc cggtagatgt gtgtttcgag ggggaggagg agacaagttt tttcaggagt     2700

ttagaagata aggtcagctc cacaataaca cggtataata gaggcactag gcttaatgaa     2760

gggcaagggg agggagaatt caagaacaca aaaggactac accaccttca gattattttg     2820

tcaggtaaaa gagcttatct gaggaaagtc attttatcag aaatttcatt tcatctagta     2880

gaggactttg atccatcctg tctcaccaat gacgacatga ggtttatttg tgaggctgtt     2940

gaaggttcaa cagaactgtc accattgtat tttacatcag ctgtcaaaga acaatgtggt     3000

ctggatgaga tggcaagaaa cctctgtaga aagttcttct cagagggtga ttggttctca     3060

tgtatgaaga tgatcttgtt acagatgaat gcaaatgcgt attcagggaa gtacagacac     3120

atgcagaggc agagcttaaa ttttaaattt gactgggaca aattggaaga agatgtaaga     3180

attagtgaaa gggaaagcaa ttctgaatct ctaagtaagg ccctttcatt gacaaaatgc     3240

atgagtgctg ctctaaagaa tctgtgtttt tactcagaag aatcaccaac atcatacact     3300

tcagttggcc ctgactctgg gagactaaaa tttgcattgt catacaaaga gcaggttggg     3360

ggaaatagag agctttacat tggggatttg aggacaaaaa tgttcacaag attggtagaa     3420

gattattttg aatccttttc tagtttcttt tcaggatctt gtttaaacaa tgacaaagag     3480

tttgaaaatg caatcttgtc aatgactatc aatgtgagag aagggttgtt aaactacagc     3540

atggatcaca gcaaatgggg accaatgatg tgcccattcc tattcttaat gcttctccaa     3600

aatctcaaac tgggtgatga tcagtacgtg cgttctggaa aagatcatgt tagcaccttg     3660

ttgacttggc atatgcataa acttgttgaa gtccctttcc ctgttgtgaa tgcaatgatg     3720

aaatcatatg ttaaatcaaa actcaagctt ctcaaagggt caggaacgac tgttacggag     3780

agaatcttta gagagtattt tgaaatgggg gtggtgccat ctcacatatc tagtctcatt     3840

gacatgggac aggggatcct acacaatgct tctgattttt acggtttaat tagtgaaagg     3900

tttatcaatt attgtattgg tgtcattttt ggagagaggc cagaagccta tacatcaagt     3960

gatgatcaga tcactttatt tgacaagaga ttgagtgact tagttgatag tgacccagaa     4020

gaagtccttg tcttgctgga attccactct cacttaagtg gtttgttgaa caagttcatc     4080

agtccaaaaa gtgtggttgg gcggtttgca gcggaattca aatccagatt ttatgtgtgg     4140

ggggaggagg tccctctcct cacgaaattt gtgtctgcgg cactacacaa tgttaagtgt     4200

aaagaaccgc atcaactttg tgagacaata gatacgattg ctgatcaagc tatagcaaat     4260

ggagttccag tttttttagt aaactgtatc cagaggagga cactggatct cttgaaatat     4320

gctaatttcc ctttagatcc attcttgtta aacactcaca ctgatgtaaa ggattggtta     4380

gatggttcta gaggttatag aatccaaaga ctcattgaag aattgtgtcc cagtgaaaca     4440

aagatcatga gaaaacttgt aagaagacta catcacaaac tcaagaacgg tgaatgtaac     4500

gaggaatttt ttctagacct cttcaacagg gaaaagaaag aggccatcct tcaattggga     4560

gagattcttg gtcttgagga tgatcttaat gagttggcaa gcatcaattg gttgaatctg     4620

aatgaaatgt tcccattgag gatggttctg agacaaaaag tggtttaccc atcagtaatg     4680

acctttcaag aggaaaagat cccctcattg attaaaacac tccaaaataa gctttgtagt     4740

aagttcacaa gaggtgcaca gaagctgttg tcagaggcaa tcaacaaatc agcttttcag     4800

agttgtgtct catccggctt tataggtctc tgtaagactt taggaagtag gtgtgtgaga     4860

aataaaaaca gggaaaatat gtatatcaga aaggtgcttg aagatctgac catggatgaa     4920

catgtcacaa gggttcacaa acaagatggt gtgatgttgt acatttgcga caagcagaga     4980

cacccagagg ctcaccgtga ccacatcaac cttttgaggc cccttctctg ggactacatt     5040

tgcatctcat tgagcaactc ttttgagctg ggtgtttggg ttttagcaga acctgtgaaa     5100

ggaaagaacg agagtaattc ggctgttagg cacttaaatc catgtgatta tgtagcaaga     5160

aaacctgaga gttcgagact actagaggat aaagtgagtt tgaatcatgt aattcaatct     5220

gtgaggcgac tgtaccccaa aatctttgag gatcagttgc tcccattcat gtctgatgtg     5280

agctcaaaaa atatgagatg gagtcccagg attaaattcc ttgacctttg tgtgctgatt     5340

gacatcaact cagagtcttt gtcactcatt tctcatgttg tcaaatggaa gagggacgaa     5400

cattacactg tgctgttttc tgatctcgtc aactctcacc aacggtcaga ctcaagttta     5460

gttgatgaat ttgttgtcag cacaagggat gtctgcaaga actttttgaa gcaagtgtat     5520

ttcgaatcat ttgtacgaga gtttgttgca acagctagga ccttaggtaa cttttcatgg     5580

ttcccccata aggacatgat gccatctgaa gatggcgctg aagcactggg acccttccaa     5640

tcatttattt tgaaagtggt gaacaagaaa atagagaggc ccatgtttag gaatgacttg     5700

cagtttggtt ttggttggtt ctcttatcgt gtgggggatg ttgtgtgtaa tgccgctatg     5760

ttaattaagc agggtttgac agatccaaaa gcatttaaat ctttaagaga tttgtgggat     5820

tacatgctca gcagcacaga ggggatattg gagttctcaa tcacagtgga tttcacacac     5880

aaccagaaca acactgactg cttgaggaaa ttttcattga tctttgtggt taaatgccaa     5940

ttacagagtc caggtgtagc tgattactta tcgtgctctc atttcttcaa aggtgaggtt     6000

gacaggagat tattagatga gtgtctcaat ctgttgagga cagaccccat ctttaaagcg     6060

aatgatggag tctttgacat taggtctgaa gagtttgaag attacatgga agaccctttg     6120

acacttggtg attcactaga acttgaacta ataggttcta gaaggattct gaatgagatc     6180

aaatctactg actttgagag gatagggcct gagtgggaac ctgtgcctct gaccataagg     6240

aagggtgccc tctttgaggg gaggaacttt gttcagaata tctctgtgaa attggagaca     6300

aaggacatga gggtctttct ggcagagctc gagggctgtg gagaaattgg tgatgtcctc     6360

ggcagcctcc tcctgcaccg attcagaact ggtgagcact tgatggagtc agaaataagt     6420

acagttcttc aggagctctg catggacaga tccgtcatgc tgacaccatt atcttttgtg     6480

ccagattggt tcaccttcag agattgtagg ctctgcttca gcaggtcaaa gaacactgta     6540

atgtatgaga caactggggg caggttcaga ctcaagggga aatcctgtga cgattggctg     6600

gcggagcggg tggccgagga gatcgactag                                      6630


<210>  64
<211>  2209
<212>  PRT
<213>  Lymphocytic choriomeningitis virus (mutant P52-2.1)

<400>  64

Met Asp Glu Thr Ile Ala Asp Leu Arg Glu Leu Cys Leu Asn Tyr Ile 
1               5                   10                  15      


Glu Gln Asp Glu Arg Leu Ser Arg Gln Lys Leu Asn Phe Leu Gly Gln 
            20                  25                  30          


Arg Glu Pro Arg Met Val Leu Ile Glu Gly Leu Lys Leu Leu Ser Arg 
        35                  40                  45              


Cys Ile Glu Ile Asp Ser Ala Asp Lys Ser Gly Cys Ile His Asn His 
    50                  55                  60                  


Asp Asp Lys Ser Val Glu Thr Ile Leu Ile Asp Ser Gly Ile Val Cys 
65                  70                  75                  80  


Pro Gly Leu Pro Leu Ile Ile Pro Asp Gly Tyr Lys Leu Ile Asp Asn 
                85                  90                  95      


Ser Leu Ile Leu Leu Glu Cys Phe Val Arg Ser Thr Pro Ala Ser Phe 
            100                 105                 110         


Glu Lys Lys Phe Ile Glu Asp Thr Asn Lys Leu Ala Cys Ile Lys Glu 
        115                 120                 125             


Asp Leu Ala Val Ala Gly Ile Thr Leu Val Pro Ile Val Asp Gly Arg 
    130                 135                 140                 


Cys Asp Tyr Asp Asn Ser Phe Met Pro Glu Trp Val Asn Phe Lys Phe 
145                 150                 155                 160 


Arg Asp Leu Leu Phe Lys Leu Leu Glu Tyr Ser Ser Gln Asp Glu Lys 
                165                 170                 175     


Val Phe Glu Glu Ser Glu Tyr Phe Arg Leu Cys Glu Ser Leu Lys Thr 
            180                 185                 190         


Thr Val Asp Lys Arg Ser Gly Met Asp Ser Met Lys Ile Leu Lys Asp 
        195                 200                 205             


Ala Arg Ser Phe His Asn Asp Glu Ile Met Lys Met Cys His Asp Gly 
    210                 215                 220                 


Val Asn Pro Asn Met Ser Cys Asp Asp Val Val Phe Gly Ile Asn Ser 
225                 230                 235                 240 


Phe Phe Gly Arg Phe Arg Arg Asp Leu Leu Asn Gly Lys Leu Lys Arg 
                245                 250                 255     


Asn Phe Gln Lys Val Ser Pro Gly Gly Leu Ile Lys Glu Phe Ser Glu 
            260                 265                 270         


Leu Tyr Glu Thr Leu Thr Asp Asn Asp Asp Ile Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Ala Val Glu Ser Cys Pro Leu Met Arg Phe Ile Thr Ala Glu Thr 
    290                 295                 300                 


His Gly His Glu Arg Gly Ser Asp Ala Asn Thr Glu Tyr Glu Arg Leu 
305                 310                 315                 320 


Leu Ser Met Leu Asn Lys Val Lys Ser Leu Lys Leu Leu Asn Thr Arg 
                325                 330                 335     


Arg Arg Gln Leu Leu Asn Leu Asp Val Leu Cys Leu Ser Ser Leu Ile 
            340                 345                 350         


Lys Gln Ser Ile Ser Lys Gly Leu Glu Asn Asp Lys His Trp Val Gly 
        355                 360                 365             


Cys Cys Tyr Ser Ser Val Asn Asp Arg Leu Val Ser Leu Gln Ser Thr 
    370                 375                 380                 


Lys Glu Glu Phe Met Arg Leu Leu Lys Asn Arg Arg Lys Ser Arg Val 
385                 390                 395                 400 


His Lys Lys Ala Ser Leu Asp Glu Leu Phe Arg Val Ser Ile Asn Glu 
                405                 410                 415     


Phe Ile Ala Lys Ile Gln Lys Cys Leu Ser Thr Val Gly Leu Ser Phe 
            420                 425                 430         


Glu His Tyr Gly Leu Ser Glu Cys Leu Val Gln Glu Cys His Ile Pro 
        435                 440                 445             


Phe Ala Glu Phe Glu Asn Phe Met Arg Ala Gly Thr His Pro Val Met 
    450                 455                 460                 


His Tyr Thr Lys Phe Glu Asp Tyr Thr Phe Gln Pro Asn Ile Glu Gln 
465                 470                 475                 480 


Leu Arg Gly Leu Gln Ser Leu Arg Lys Leu Ser Ser Val Cys Leu Ala 
                485                 490                 495     


Leu Thr Asn Ser Met Lys Thr Ser Ser Val Ala Arg Leu Arg Gln Asn 
            500                 505                 510         


Gln Leu Gly Ser Val Arg Tyr Gln Val Val Glu Cys Lys Glu Val Phe 
        515                 520                 525             


Cys Gln Ile Ile Lys Leu Asp Ser Glu Glu Tyr His Leu Leu Tyr Gln 
    530                 535                 540                 


Lys Thr Gly Glu Ser Ser Arg Cys Tyr Ser Ile Gln Gly Pro Asp Gly 
545                 550                 555                 560 


His Leu Ile Ser Phe Tyr Ala Asp Pro Lys Arg Phe Phe Leu Pro Ile 
                565                 570                 575     


Phe Ser Asp Glu Val Leu His Asn Met Ile Asp Thr Met Ile Ser Trp 
            580                 585                 590         


Ile Arg Ser Cys Pro Asp Leu Lys Asp Ser Leu Ile Asp Ile Glu Thr 
        595                 600                 605             


Ala Leu Arg Thr Leu Ile Leu Leu Met Leu Thr Asn Pro Thr Lys Arg 
    610                 615                 620                 


Asn Gln Lys Gln Val Gln Asn Ile Arg Tyr Leu Val Met Ala Ile Val 
625                 630                 635                 640 


Ser Asp Phe Ser Ser Thr Ser Leu Met Asp Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Ile Thr Pro Ala Glu Lys Val Val Tyr Arg Leu Leu Arg Phe Leu Ile 
            660                 665                 670         


Arg Thr Ile Phe Gly Thr Gly Glu Lys Val Leu Leu Ser Ala Lys Phe 
        675                 680                 685             


Lys Phe Met Leu Asn Val Ser Tyr Leu Cys His Leu Ile Thr Lys Glu 
    690                 695                 700                 


Thr Pro Asp Arg Leu Thr Asp Gln Ile Lys Cys Phe Glu Lys Phe Phe 
705                 710                 715                 720 


Glu Pro Lys Ser Glu Phe Gly Phe Phe Val Asn Pro Lys Glu Thr Ile 
                725                 730                 735     


Thr Pro Glu Glu Glu Cys Val Phe Tyr Glu Gln Met Lys Lys Phe Thr 
            740                 745                 750         


Gly Lys Asp Ile Asp Cys Gln His Ser Thr Pro Gly Val Asn Leu Glu 
        755                 760                 765             


Ile Phe Ser Met Met Val Ser Ser Phe Asn Asn Gly Thr Leu Ile Leu 
    770                 775                 780                 


Lys Gly Glu Lys Arg Leu Asn Asn Leu Asp Pro Met Thr Asn Ser Gly 
785                 790                 795                 800 


Cys Ala Thr Ala Leu Asp Leu Ala Ser Asn Lys Ser Val Val Val Asn 
                805                 810                 815     


Lys His Leu Asn Gly Glu Arg Leu Leu Glu Tyr Asp Phe Asn Lys Leu 
            820                 825                 830         


Leu Val Ser Ala Val Ser Gln Ile Thr Glu Gly Phe Met Arg Lys Gln 
        835                 840                 845             


Lys Tyr Lys Leu Arg His Ser Asp Tyr Glu Tyr Lys Val Ser Lys Leu 
    850                 855                 860                 


Val Ser Arg Leu Val Ile Gly Ser Arg Lys Thr Glu Val Asp Lys Leu 
865                 870                 875                 880 


Glu Asp Asp Pro Val Asp Val Cys Phe Glu Gly Glu Glu Glu Thr Ser 
                885                 890                 895     


Phe Phe Arg Ser Leu Glu Asp Lys Val Ser Ser Thr Ile Thr Arg Tyr 
            900                 905                 910         


Asn Arg Gly Thr Arg Leu Asn Glu Gly Gln Gly Glu Gly Glu Phe Lys 
        915                 920                 925             


Asn Thr Lys Gly Leu His His Leu Gln Ile Ile Leu Ser Gly Lys Arg 
    930                 935                 940                 


Ala Tyr Leu Arg Lys Val Ile Leu Ser Glu Ile Ser Phe His Leu Val 
945                 950                 955                 960 


Glu Asp Phe Asp Pro Ser Cys Leu Thr Asn Asp Asp Met Arg Phe Ile 
                965                 970                 975     


Cys Glu Ala Val Glu Gly Ser Thr Glu Leu Ser Pro Leu Tyr Phe Thr 
            980                 985                 990         


Ser Ala Val Lys Glu Gln Cys Gly  Leu Asp Glu Met Ala  Arg Asn Leu 
        995                 1000                 1005             


Cys Arg  Lys Phe Phe Ser Glu  Gly Asp Trp Phe Ser  Cys Met Lys 
    1010                 1015                 1020             


Met Ile  Leu Leu Gln Met Asn  Ala Asn Ala Tyr Ser  Gly Lys Tyr 
    1025                 1030                 1035             


Arg His  Met Gln Arg Gln Ser  Leu Asn Phe Lys Phe  Asp Trp Asp 
    1040                 1045                 1050             


Lys Leu  Glu Glu Asp Val Arg  Ile Ser Glu Arg Glu  Ser Asn Ser 
    1055                 1060                 1065             


Glu Ser  Leu Ser Lys Ala Leu  Ser Leu Thr Lys Cys  Met Ser Ala 
    1070                 1075                 1080             


Ala Leu  Lys Asn Leu Cys Phe  Tyr Ser Glu Glu Ser  Pro Thr Ser 
    1085                 1090                 1095             


Tyr Thr  Ser Val Gly Pro Asp  Ser Gly Arg Leu Lys  Phe Ala Leu 
    1100                 1105                 1110             


Ser Tyr  Lys Glu Gln Val Gly  Gly Asn Arg Glu Leu  Tyr Ile Gly 
    1115                 1120                 1125             


Asp Leu  Arg Thr Lys Met Phe  Thr Arg Leu Val Glu  Asp Tyr Phe 
    1130                 1135                 1140             


Glu Ser  Phe Ser Ser Phe Phe  Ser Gly Ser Cys Leu  Asn Asn Asp 
    1145                 1150                 1155             


Lys Glu  Phe Glu Asn Ala Ile  Leu Ser Met Thr Ile  Asn Val Arg 
    1160                 1165                 1170             


Glu Gly  Leu Leu Asn Tyr Ser  Met Asp His Ser Lys  Trp Gly Pro 
    1175                 1180                 1185             


Met Met  Cys Pro Phe Leu Phe  Leu Met Leu Leu Gln  Asn Leu Lys 
    1190                 1195                 1200             


Leu Gly  Asp Asp Gln Tyr Val  Arg Ser Gly Lys Asp  His Val Ser 
    1205                 1210                 1215             


Thr Leu  Leu Thr Trp His Met  His Lys Leu Val Glu  Val Pro Phe 
    1220                 1225                 1230             


Pro Val  Val Asn Ala Met Met  Lys Ser Tyr Val Lys  Ser Lys Leu 
    1235                 1240                 1245             


Lys Leu  Leu Lys Gly Ser Gly  Thr Thr Val Thr Glu  Arg Ile Phe 
    1250                 1255                 1260             


Arg Glu  Tyr Phe Glu Met Gly  Val Val Pro Ser His  Ile Ser Ser 
    1265                 1270                 1275             


Leu Ile  Asp Met Gly Gln Gly  Ile Leu His Asn Ala  Ser Asp Phe 
    1280                 1285                 1290             


Tyr Gly  Leu Ile Ser Glu Arg  Phe Ile Asn Tyr Cys  Ile Gly Val 
    1295                 1300                 1305             


Ile Phe  Gly Glu Arg Pro Glu  Ala Tyr Thr Ser Ser  Asp Asp Gln 
    1310                 1315                 1320             


Ile Thr  Leu Phe Asp Lys Arg  Leu Ser Asp Leu Val  Asp Ser Asp 
    1325                 1330                 1335             


Pro Glu  Glu Val Leu Val Leu  Leu Glu Phe His Ser  His Leu Ser 
    1340                 1345                 1350             


Gly Leu  Leu Asn Lys Phe Ile  Ser Pro Lys Ser Val  Val Gly Arg 
    1355                 1360                 1365             


Phe Ala  Ala Glu Phe Lys Ser  Arg Phe Tyr Val Trp  Gly Glu Glu 
    1370                 1375                 1380             


Val Pro  Leu Leu Thr Lys Phe  Val Ser Ala Ala Leu  His Asn Val 
    1385                 1390                 1395             


Lys Cys  Lys Glu Pro His Gln  Leu Cys Glu Thr Ile  Asp Thr Ile 
    1400                 1405                 1410             


Ala Asp  Gln Ala Ile Ala Asn  Gly Val Pro Val Phe  Leu Val Asn 
    1415                 1420                 1425             


Cys Ile  Gln Arg Arg Thr Leu  Asp Leu Leu Lys Tyr  Ala Asn Phe 
    1430                 1435                 1440             


Pro Leu  Asp Pro Phe Leu Leu  Asn Thr His Thr Asp  Val Lys Asp 
    1445                 1450                 1455             


Trp Leu  Asp Gly Ser Arg Gly  Tyr Arg Ile Gln Arg  Leu Ile Glu 
    1460                 1465                 1470             


Glu Leu  Cys Pro Ser Glu Thr  Lys Ile Met Arg Lys  Leu Val Arg 
    1475                 1480                 1485             


Arg Leu  His His Lys Leu Lys  Asn Gly Glu Cys Asn  Glu Glu Phe 
    1490                 1495                 1500             


Phe Leu  Asp Leu Phe Asn Arg  Glu Lys Lys Glu Ala  Ile Leu Gln 
    1505                 1510                 1515             


Leu Gly  Glu Ile Leu Gly Leu  Glu Asp Asp Leu Asn  Glu Leu Ala 
    1520                 1525                 1530             


Ser Ile  Asn Trp Leu Asn Leu  Asn Glu Met Phe Pro  Leu Arg Met 
    1535                 1540                 1545             


Val Leu  Arg Gln Lys Val Val  Tyr Pro Ser Val Met  Thr Phe Gln 
    1550                 1555                 1560             


Glu Glu  Lys Ile Pro Ser Leu  Ile Lys Thr Leu Gln  Asn Lys Leu 
    1565                 1570                 1575             


Cys Ser  Lys Phe Thr Arg Gly  Ala Gln Lys Leu Leu  Ser Glu Ala 
    1580                 1585                 1590             


Ile Asn  Lys Ser Ala Phe Gln  Ser Cys Val Ser Ser  Gly Phe Ile 
    1595                 1600                 1605             


Gly Leu  Cys Lys Thr Leu Gly  Ser Arg Cys Val Arg  Asn Lys Asn 
    1610                 1615                 1620             


Arg Glu  Asn Met Tyr Ile Arg  Lys Val Leu Glu Asp  Leu Thr Met 
    1625                 1630                 1635             


Asp Glu  His Val Thr Arg Val  His Lys Gln Asp Gly  Val Met Leu 
    1640                 1645                 1650             


Tyr Ile  Cys Asp Lys Gln Arg  His Pro Glu Ala His  Arg Asp His 
    1655                 1660                 1665             


Ile Asn  Leu Leu Arg Pro Leu  Leu Trp Asp Tyr Ile  Cys Ile Ser 
    1670                 1675                 1680             


Leu Ser  Asn Ser Phe Glu Leu  Gly Val Trp Val Leu  Ala Glu Pro 
    1685                 1690                 1695             


Val Lys  Gly Lys Asn Glu Ser  Asn Ser Ala Val Arg  His Leu Asn 
    1700                 1705                 1710             


Pro Cys  Asp Tyr Val Ala Arg  Lys Pro Glu Ser Ser  Arg Leu Leu 
    1715                 1720                 1725             


Glu Asp  Lys Val Ser Leu Asn  His Val Ile Gln Ser  Val Arg Arg 
    1730                 1735                 1740             


Leu Tyr  Pro Lys Ile Phe Glu  Asp Gln Leu Leu Pro  Phe Met Ser 
    1745                 1750                 1755             


Asp Val  Ser Ser Lys Asn Met  Arg Trp Ser Pro Arg  Ile Lys Phe 
    1760                 1765                 1770             


Leu Asp  Leu Cys Val Leu Ile  Asp Ile Asn Ser Glu  Ser Leu Ser 
    1775                 1780                 1785             


Leu Ile  Ser His Val Val Lys  Trp Lys Arg Asp Glu  His Tyr Thr 
    1790                 1795                 1800             


Val Leu  Phe Ser Asp Leu Val  Asn Ser His Gln Arg  Ser Asp Ser 
    1805                 1810                 1815             


Ser Leu  Val Asp Glu Phe Val  Val Ser Thr Arg Asp  Val Cys Lys 
    1820                 1825                 1830             


Asn Phe  Leu Lys Gln Val Tyr  Phe Glu Ser Phe Val  Arg Glu Phe 
    1835                 1840                 1845             


Val Ala  Thr Ala Arg Thr Leu  Gly Asn Phe Ser Trp  Phe Pro His 
    1850                 1855                 1860             


Lys Asp  Met Met Pro Ser Glu  Asp Gly Ala Glu Ala  Leu Gly Pro 
    1865                 1870                 1875             


Phe Gln  Ser Phe Ile Leu Lys  Val Val Asn Lys Lys  Ile Glu Arg 
    1880                 1885                 1890             


Pro Met  Phe Arg Asn Asp Leu  Gln Phe Gly Phe Gly  Trp Phe Ser 
    1895                 1900                 1905             


Tyr Arg  Val Gly Asp Val Val  Cys Asn Ala Ala Met  Leu Ile Lys 
    1910                 1915                 1920             


Gln Gly  Leu Thr Asp Pro Lys  Ala Phe Lys Ser Leu  Arg Asp Leu 
    1925                 1930                 1935             


Trp Asp  Tyr Met Leu Ser Ser  Thr Glu Gly Ile Leu  Glu Phe Ser 
    1940                 1945                 1950             


Ile Thr  Val Asp Phe Thr His  Asn Gln Asn Asn Thr  Asp Cys Leu 
    1955                 1960                 1965             


Arg Lys  Phe Ser Leu Ile Phe  Val Val Lys Cys Gln  Leu Gln Ser 
    1970                 1975                 1980             


Pro Gly  Val Ala Asp Tyr Leu  Ser Cys Ser His Phe  Phe Lys Gly 
    1985                 1990                 1995             


Glu Val  Asp Arg Arg Leu Leu  Asp Glu Cys Leu Asn  Leu Leu Arg 
    2000                 2005                 2010             


Thr Asp  Pro Ile Phe Lys Ala  Asn Asp Gly Val Phe  Asp Ile Arg 
    2015                 2020                 2025             


Ser Glu  Glu Phe Glu Asp Tyr  Met Glu Asp Pro Leu  Thr Leu Gly 
    2030                 2035                 2040             


Asp Ser  Leu Glu Leu Glu Leu  Ile Gly Ser Arg Arg  Ile Leu Asn 
    2045                 2050                 2055             


Glu Ile  Lys Ser Thr Asp Phe  Glu Arg Ile Gly Pro  Glu Trp Glu 
    2060                 2065                 2070             


Pro Val  Pro Leu Thr Ile Arg  Lys Gly Ala Leu Phe  Glu Gly Arg 
    2075                 2080                 2085             


Asn Phe  Val Gln Asn Ile Ser  Val Lys Leu Glu Thr  Lys Asp Met 
    2090                 2095                 2100             


Arg Val  Phe Leu Ala Glu Leu  Glu Gly Cys Gly Glu  Ile Gly Asp 
    2105                 2110                 2115             


Val Leu  Gly Ser Leu Leu Leu  His Arg Phe Arg Thr  Gly Glu His 
    2120                 2125                 2130             


Leu Met  Glu Ser Glu Ile Ser  Thr Val Leu Gln Glu  Leu Cys Met 
    2135                 2140                 2145             


Asp Arg  Ser Val Met Leu Thr  Pro Leu Ser Phe Val  Pro Asp Trp 
    2150                 2155                 2160             


Phe Thr  Phe Arg Asp Cys Arg  Leu Cys Phe Ser Arg  Ser Lys Asn 
    2165                 2170                 2175             


Thr Val  Met Tyr Glu Thr Thr  Gly Gly Arg Phe Arg  Leu Lys Gly 
    2180                 2185                 2190             


Lys Ser  Cys Asp Asp Trp Leu  Ala Glu Arg Val Ala  Glu Glu Ile 
    2195                 2200                 2205             


Asp 
    


