                         SEQUENCE LISTING

<110>  Glenmark Pharmaceuticals SA
       Glenmark Pharmaceuticals S.A.
 
<120>  STABLE ANTIBODY FORMULATION

<130>  GBR1302-02-PC00

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Herceptin ScFv LALA BTB Fc_DNA

<400>  1
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg atccactggt       60

gaggtgcagc tggtcgagtc tggcggcgga ctggtgcagc ctggcggctc cctgcggctg      120

tcctgcgccg cctccggctt caacatcaag gacacctaca tccactgggt gcggcaggcc      180

cctggcaagg gcctggagtg ggtggcccgg atctacccta ccaacggcta caccagatac      240

gccgactccg tgaagggccg gttcaccatc tccgccgaca cctccaagaa caccgcctac      300

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgctc cagatgggga      360

ggagatggct tctacgccat ggactactgg ggccagggca ccctggtgac cgtgtcctcc      420

ggtggcggtg gcagcggcgg tggtggttcc ggaggcggcg gttctgacat ccagatgacc      480

cagtccccct ccagcctgtc tgcctccgtg ggcgaccggg tgaccatcac ctgccgggcc      540

tcccaggacg tgaacaccgc cgtggcctgg tatcagcaga agcctggcaa ggcccctaag      600

ctgctgatct actccgcctc cttcctgtac tccggcgtgc cttcccggtt ctccggctcc      660

cggtccggca ccgacttcac cctgaccatc tcctccctgc agcctgagga cttcgccacc      720

tactactgcc agcagcacta caccacccct cctaccttcg gccagggcac caaggtggag      780

atcaagaggg gaggaggagg taccgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgccg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaaggacag cccagggaac ctgaggtggc cacattccca     1200

cctagccggg acgagctgac aaaaaatcag gtcaccctcg tctgtctcgt gaccggcttt     1260

tacccttccg acattgccgt ggaatgggaa tccaatgggc agcccgagaa caattacaag     1320

acagaccccc ccctgctgga atccgatggc agcttcgccc tgagcagccg gctgcgggtg     1380

gacaagtcca gatggcagca ggggaatgtc ttttcctgct ccgtcatgca tgaagccctc     1440

cacaatcatt atacacagaa aagcctgagc ctgtctcctg gcaagtgata a              1491


<210>  2
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Herceptin ScFv LALA BTB Fc_Protein

<400>  2

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
        195                 200                 205             


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly Thr Asp Lys Thr His 
            260                 265                 270         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
305                 310                 315                 320 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Glu Val Ala Thr Phe Pro 
385                 390                 395                 400 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Thr Leu Val Cys Leu 
                405                 410                 415     


Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Asp Pro Pro Leu Leu Glu Ser 
        435                 440                 445             


Asp Gly Ser Phe Ala Leu Ser Ser Arg Leu Arg Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495 


<210>  3
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OKT3 H11 1133 LALA BTA_DNA

<400>  3
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg atccactggt       60

gaagtgcagc tggtggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg      120

agctgtgccg ccagcggcta caccttcacc cggtacacaa tgcactgggt gcgccaggcc      180

cctggcaagg gactggaatg gatcggctac atcaacccca gccggggcta cacctactac      240

gccgatagcg tgaagggccg gttcaccctc agcaccgaca agagcaagaa caccgcctac      300

ctgcagatga gctccctgcg ggccgaggac accgccgtgt actactgcgc ccggtactac      360

gacgaccact actgcctgga ctactggggc cagggcacac tcgtgacagt gtctagcgcg      420

tcgaccaagg gccccagcgt gttcccgcta gcccccagca gcaagagcac cagcggcggc      480

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgttac cgtgtcctgg      540

aactctggag ccctgacctc cggcgtgcac accttccccg ccgtgctcca gagcagcggc      600

ctgtacagcc tgagcagcgt ggtgacagtg cccagcagca gcctgggaac ccagacctac      660

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag      720

agctgcgaca aaactcacac ctgcccaccc tgccctgccc ctgaggccgc cggcggaccc      780

tccgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa      840

gtgacctgcg tggtggtgga tgtgtcccac gaggaccccg aggtgcagtt caagtggtac      900

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc      960

accttccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag     1020

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgagaaaac catcagcaag     1080

acaaagggcc agccccgcga gcccgccgtg tacacactgc ctccaagccg ggaagagatg     1140

accaagaacc aagtgaagct cgtgtgcctc gtgaccggct tctacccctc cgatatcgcc     1200

gtggaatggg agagcagcgg ccagcccgag aacaactact acaccacccc ccccatgctg     1260

gacagcgacg gctcttttag cctggtgtcc tggctgaatg tggacaagag ccggtggcag     1320

cagggcaaca tcttcagctg cagcgtgatg cacgaggccc tgcacaaccg gttcacccag     1380

aagtccctga gcctgtctcc tggcaagtga taa                                  1413


<210>  4
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 H11 1133 LALA BTA_Protein

<400>  4

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Leu Ser Thr Asp Lys Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
                245                 250                 255     


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Ala Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Lys Leu Val Cys Leu Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Tyr Thr Thr 
                405                 410                 415     


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Ser Leu Val Ser Trp Leu 
            420                 425                 430         


Asn Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  5
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OKT3 L8 LC_DNA

<400>  5
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg atccactggt       60

gatatccagc tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc      120

atcacctgta gagccagcag cagcgtgtcc tacgtggcct ggtatcagca gaagcccggc      180

aaggccccca agaggtggat ctacgacacc tccaagctgt actccggcgt gcccagcaga      240

ttcagcggca gcggatccgg caccgactac accctgacca tcagctccct gcagcccgag      300

gacttcgcca cctactactg ccagcagtgg tccagcaacc cccccacatt tggacagggc      360

accaaggtgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc      420

gacgagcagc tgaagagcgg caccgcctcc gtggtgtgcc tgctgaacaa cttctacccc      480

cgggaggcca aggtgcagtg gaaggtggac aacgccctcc agagcggcaa cagccaggaa      540

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      600

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aggtgaccca ccagggcctg      660

tccagccccg tgaccaagag cttcaaccgg ggcgagtgc                             699


<210>  6
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 L8 LC_Protein

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Arg Trp Ile Tyr Asp Thr Ser Lys Leu Tyr Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 
            100                 105                 110         


Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


