                         б

<110>  Ϻԭϸҽѧ޹˾
 
<120>  ߵڼϸ;

<130>  0065-PA-021

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  296
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NFATλ

<400>  1
actagtggag gaaaaactgt ttcatacaga aggcgtggag gaaaaactgt ttcatacaga       60

aggcgtggag gaaaaactgt ttcatacaga aggcgtggag gaaaaactgt ttcatacaga      120

aggcgtggag gaaaaactgt ttcatacaga aggcgtggag gaaaaactgt ttcatacaga      180

aggcgtcatt ttgacacccc cataatattt ttccagaatt aacagtataa attgcatctc      240

ttgttcaaga gttccctatc actctttaat cactactcac agtaacctca actcct          296


<210>  2
<211>  789
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  4D5scfv

<400>  2
atggccctgc ctgtgacagc cctgctcctg cctctcgccc tgctgctgca tgccgctaga       60

cctgaggttc agctggtgga gtctggcggt ggcctggtgc agccaggggg ctcactccgt      120

ttgtcctgtg cagcttctgg cttcaacatt aaagacacct atatacactg ggtgcgtcag      180

gccccgggta agggcctgga atgggttgca aggatttatc ctacgaatgg ttatactaga      240

tatgccgata gcgtcaaggg ccgtttcact ataagcgcag acacatccaa aaacacagcc      300

tacctgcaga tgaacagcct gcgtgctgag gacactgccg tctattattg ttctagatgg      360

ggaggggacg gcttctatgc tatggactac tggggtcaag gaaccctggt caccgtctcc      420

tcgggaggag gaggcagcgg cggaggaggc tccggcggcg gcggctctga catccagatg      480

acccagtccc cgagctccct gtccgcctct gtgggcgata gggttaccat cacctgccgt      540

gccagtcagg atgtgaatac tgctgtagcc tggtatcaac agaaaccagg aaaagctccg      600

aaactactga tttactcggc atccttcctc tactctggag tcccttctcg cttctctggt      660

tccagatctg ggacggattt cactctgacc atcagcagtc tgcagccgga agacttcgca      720

acttattact gtcagcaaca ttatactact cctcccacgt tcggacaggg taccaaggtg      780

gagatcaaa                                                              789


<210>  3
<211>  786
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  FRP5SCFV

<400>  3
atggccctgc ctgtgacagc cctgctcctg cctctcgccc tgctgctgca tgccgctaga       60

cctcaggtcc agctgcagca gagcggaccc gagctcaaga agcccggcga gaccgtgaag      120

atcagctgta aggccagcgg ctaccccttt accaactatg gaatgaactg ggtgaagcaa      180

gctcccggcc agggcctgaa gtggatgggc tggatcaaca caagcaccgg agaaagcacc      240

ttcgctgacg acttcaaggg cagatttgac ttctccctcg agacctccgc caacaccgcc      300

tacctgcaga tcaacaatct gaagtccgag gacagcgcta cctacttctg cgccagatgg      360

gaggtgtacc atggctacgt cccttattgg ggccaaggca ccaccgtgac cgtgagcagc      420

ggaggaggcg gttctggagg cggcggcagc ggcggcggcg gcagcgacat tcagctgacc      480

cagtcccaca agttcctgag cacctccgtg ggcgacaggg tgagcattac ctgcaaggcc      540

agccaggacg tgtacaatgc cgtggcctgg taccagcaga agcctggaca gagccccaag      600

ctgctgatct acagcgcttc ctccaggtac accggcgtcc cttccagatt taccggctcc      660

ggctccggcc ccgacttcac cttcaccatc agctccgtgc aggccgaaga cctggccgtg      720

tacttctgcc aacagcactt caggaccccc ttcacctttg gcagcggaac caagctggag      780

atcaaa                                                                 786


<210>  4
<211>  672
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8-CD137-CD3

<400>  4
accaccaccc ccgcccccag accccctaca cccgctccca caattgcttc ccagcctctg       60

agcctgaggc ccgaggcttg taggcctgcc gctggaggcg ccgtgcatac aagaggcctg      120

gacttcgctt gcgacatcta catctgggct cccctggccg gcacatgtgg agtgctcctc      180

ctgagcctgg tgatcacact ctactgcaag aggggcagaa agaagctgct ctacatcttc      240

aagcagccct tcatgaggcc cgtgcagaca acccaggagg aggacggctg ctcctgcaga      300

ttccctgagg aggaggaggg cggctgcgag ctgagagtga aattctccag gagcgccgat      360

gcccccgcct acaagcaggg ccaaaaccag ctctacaacg agctgaacct cggcaggaga      420

gaggagtatg atgtgctcga caagaggagg ggaagggacc ccgaaatggg cggcaagccc      480

aggaggaaga acccccagga aggcctgtac aatgagctgc agaaggacaa aatggccgaa      540

gcctatagcg agatcggaat gaaaggcgag aggaggaggg gcaaaggcca tgacggcctg      600

tatcagggcc tgagcaccgc cacaaaggac acctacgacg ccctccacat gcaggctctg      660

ccccctagga at                                                          672


<210>  5
<211>  57
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  2A

<400>  5
gccaccaatt ttagcctgct gaaacaggcc ggagacgtgg aggaaaaccc cggcccc          57


<210>  6
<211>  720
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  GFP

<400>  6
atggtgtcca aaggagagga gctgttcacc ggagtggtgc ccatcctggt ggagctggac       60

ggcgacgtga acggacataa gttcagcgtg tccggcgagg gagaaggcga cgccacatac      120

ggcaagctca ccctgaagtt catctgcaca accggcaagc tgcccgtgcc ttggcccaca      180

ctggtgacca ccctgaccta cggcgtgcag tgcttctcca gataccccga ccacatgaag      240

cagcacgact tcttcaaatc cgccatgccc gagggatacg tgcaggagag gaccatcttc      300

ttcaaggacg acggcaacta taagaccagg gccgaggtga agttcgaggg cgataccctg      360

gtgaacagga tcgagctgaa gggcattgac ttcaaggagg acggaaacat cctgggccac      420

aagctcgagt acaactacaa cagccacaat gtgtacatca tggccgacaa gcagaagaat      480

ggcattaagg tgaacttcaa gattaggcac aacatcgagg acggctccgt gcagctggcc      540

gaccattacc agcagaacac ccccattggc gatggccccg tcctgctgcc tgacaaccac      600

tacctgagca cacagtccgc cctgagcaaa gaccctaacg agaagaggga ccacatggtc      660

ctgctggagt tcgtgaccgc cgccggcatt accctgggca tggatgagct gtacaagtga      720


<210>  7
<211>  1176
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  EF1a

<400>  7
gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg       60

tcggcaattg aaccggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg      120

tgtactggct ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg      180

ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac acaggtaagt gccgtgtgtg      240

gttcccgcgg gcctggcctc tttacgggtt atggcccttg cgtgccttga attacttcca      300

cgcccctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag tgggtgggag      360

agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga ggcctggcct      420

gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct cgctgctttc      480

gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt tttctggcaa      540

gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt tggggccgcg      600

ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg cctgcgagcg      660

cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct ggtgcctggc      720

ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc ggcaccagtt      780

gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa atggaggacg      840

cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc ctttccgtcc      900

tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca cctcgattag      960

ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta tgcgatggag     1020

tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt gatgtaattc     1080

tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc tcagacagtg     1140

gttcaaagtt tttttcttcc atttcaggtg tcgtga                               1176


<210>  8
<211>  120
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  PEST

<400>  8
agccacggct tcccccctga ggtggaggaa caggctgctg gcaccctgcc tatgagctgc       60

gcccaggaga gcggcatgga tagacatccc gccgcctgtg ccagcgccag aatcaacgtg      120


<210>  9
<211>  2043
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  HER2

<400>  9
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggggcagc     2040

ggc                                                                   2043


<210>  10
<211>  711
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  mCHERRY

<400>  10
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaagta a               711


<210>  11
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  4D5ScFv f

<400>  11
gaggttcagc tggtggagtc tggc                                              24


<210>  12
<211>  59
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  4D5ScFv r

<400>  12
tcctccacgt ctccggcctg tttcagcagg ctaaaattgg tggcattcct agggggcag        59


<210>  13
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  FRP5ScFv f

<400>  13
ggtactgttg gtaaagccac catggccctg cctgtg                                 36


<210>  14
<211>  28
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  FRP5ScFv r

<400>  14
gcgggggtgg tggttttgat ctccagct                                          28


<210>  15
<211>  1765
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NFAT-4D5CAR

<400>  15
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt      120

ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt      180

cattttgaca cccccataat atttttccag aattaacagt ataaattgca tctcttgttc      240

aagagttccc tatcactctt taatcactac tcacagtaac ctcaactcct gcggatccgc      300

caccatggcc ctgcctgtga cagccctgct cctgcctctc gccctgctgc tgcatgccgc      360

tagacctgag gttcagctgg tggagtctgg cggtggcctg gtgcagccag ggggctcact      420

ccgtttgtcc tgtgcagctt ctggcttcaa cattaaagac acctatatac actgggtgcg      480

tcaggccccg ggtaagggcc tggaatgggt tgcaaggatt tatcctacga atggttatac      540

tagatatgcc gatagcgtca agggccgttt cactataagc gcagacacat ccaaaaacac      600

agcctacctg cagatgaaca gcctgcgtgc tgaggacact gccgtctatt attgttctag      660

atggggaggg gacggcttct atgctatgga ctactggggt caaggaaccc tggtcaccgt      720

ctcctcggga ggaggaggca gcggcggagg aggctccggc ggcggcggct ctgacatcca      780

gatgacccag tccccgagct ccctgtccgc ctctgtgggc gatagggtta ccatcacctg      840

ccgtgccagt caggatgtga atactgctgt agcctggtat caacagaaac caggaaaagc      900

tccgaaacta ctgatttact cggcatcctt cctctactct ggagtccctt ctcgcttctc      960

tggttccaga tctgggacgg atttcactct gaccatcagc agtctgcagc cggaagactt     1020

cgcaacttat tactgtcagc aacattatac tactcctccc acgttcggac agggtaccaa     1080

ggtggagatc aaaaccacca cccccgcccc cagaccccct acacccgctc ccacaattgc     1140

ttcccagcct ctgagcctga ggcccgaggc ttgtaggcct gccgctggag gcgccgtgca     1200

tacaagaggc ctggacttcg cttgcgacat ctacatctgg gctcccctgg ccggcacatg     1260

tggagtgctc ctcctgagcc tggtgatcac actctactgc aagaggggca gaaagaagct     1320

gctctacatc ttcaagcagc ccttcatgag gcccgtgcag acaacccagg aggaggacgg     1380

ctgctcctgc agattccctg aggaggagga gggcggctgc gagctgagag tgaaattctc     1440

caggagcgcc gatgcccccg cctacaagca gggccaaaac cagctctaca acgagctgaa     1500

cctcggcagg agagaggagt atgatgtgct cgacaagagg aggggaaggg accccgaaat     1560

gggcggcaag cccaggagga agaaccccca ggaaggcctg tacaatgagc tgcagaagga     1620

caaaatggcc gaagcctata gcgagatcgg aatgaaaggc gagaggagga ggggcaaagg     1680

ccatgacggc ctgtatcagg gcctgagcac cgccacaaag gacacctacg acgccctcca     1740

catgcaggct ctgcccccta ggaat                                           1765


<210>  16
<211>  2658
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  EF1a-4D5CAR

<400>  16
gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg       60

tcggcaattg aaccggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg      120

tgtactggct ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg      180

ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac acaggtaagt gccgtgtgtg      240

gttcccgcgg gcctggcctc tttacgggtt atggcccttg cgtgccttga attacttcca      300

cgcccctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag tgggtgggag      360

agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga ggcctggcct      420

gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct cgctgctttc      480

gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt tttctggcaa      540

gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt tggggccgcg      600

ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg cctgcgagcg      660

cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct ggtgcctggc      720

ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc ggcaccagtt      780

gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa atggaggacg      840

cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc ctttccgtcc      900

tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca cctcgattag      960

ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta tgcgatggag     1020

tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt gatgtaattc     1080

tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc tcagacagtg     1140

gttcaaagtt tttttcttcc atttcaggtg tcgtgaagcg gccgcggatc cgccaccatg     1200

gccctgcctg tgacagccct gctcctgcct ctcgccctgc tgctgcatgc cgctagacct     1260

gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg     1320

tcctgtgcag cttctggctt caacattaaa gacacctata tacactgggt gcgtcaggcc     1380

ccgggtaagg gcctggaatg ggttgcaagg atttatccta cgaatggtta tactagatat     1440

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac     1500

ctgcagatga acagcctgcg tgctgaggac actgccgtct attattgttc tagatgggga     1560

ggggacggct tctatgctat ggactactgg ggtcaaggaa ccctggtcac cgtctcctcg     1620

ggaggaggag gcagcggcgg aggaggctcc ggcggcggcg gctctgacat ccagatgacc     1680

cagtccccga gctccctgtc cgcctctgtg ggcgataggg ttaccatcac ctgccgtgcc     1740

agtcaggatg tgaatactgc tgtagcctgg tatcaacaga aaccaggaaa agctccgaaa     1800

ctactgattt actcggcatc cttcctctac tctggagtcc cttctcgctt ctctggttcc     1860

agatctggga cggatttcac tctgaccatc agcagtctgc agccggaaga cttcgcaact     1920

tattactgtc agcaacatta tactactcct cccacgttcg gacagggtac caaggtggag     1980

atcaaaacca ccacccccgc ccccagaccc cctacacccg ctcccacaat tgcttcccag     2040

cctctgagcc tgaggcccga ggcttgtagg cctgccgctg gaggcgccgt gcatacaaga     2100

ggcctggact tcgcttgcga catctacatc tgggctcccc tggccggcac atgtggagtg     2160

ctcctcctga gcctggtgat cacactctac tgcaagaggg gcagaaagaa gctgctctac     2220

atcttcaagc agcccttcat gaggcccgtg cagacaaccc aggaggagga cggctgctcc     2280

tgcagattcc ctgaggagga ggagggcggc tgcgagctga gagtgaaatt ctccaggagc     2340

gccgatgccc ccgcctacaa gcagggccaa aaccagctct acaacgagct gaacctcggc     2400

aggagagagg agtatgatgt gctcgacaag aggaggggaa gggaccccga aatgggcggc     2460

aagcccagga ggaagaaccc ccaggaaggc ctgtacaatg agctgcagaa ggacaaaatg     2520

gccgaagcct atagcgagat cggaatgaaa ggcgagagga ggaggggcaa aggccatgac     2580

ggcctgtatc agggcctgag caccgccaca aaggacacct acgacgccct ccacatgcag     2640

gctctgcccc ctaggaat                                                   2658


<210>  17
<211>  2655
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  EF1a-FRP5CAR

<400>  17
gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg       60

tcggcaattg aaccggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg      120

tgtactggct ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg      180

ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac acaggtaagt gccgtgtgtg      240

gttcccgcgg gcctggcctc tttacgggtt atggcccttg cgtgccttga attacttcca      300

cgcccctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag tgggtgggag      360

agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga ggcctggcct      420

gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct cgctgctttc      480

gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt tttctggcaa      540

gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt tggggccgcg      600

ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg cctgcgagcg      660

cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct ggtgcctggc      720

ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc ggcaccagtt      780

gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa atggaggacg      840

cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc ctttccgtcc      900

tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca cctcgattag      960

ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta tgcgatggag     1020

tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt gatgtaattc     1080

tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc tcagacagtg     1140

gttcaaagtt tttttcttcc atttcaggtg tcgtgaagcg gccgcggatc cgccaccatg     1200

gccctgcctg tgacagccct gctcctgcct ctcgccctgc tgctgcatgc cgctagacct     1260

caggtccagc tgcagcagag cggacccgag ctcaagaagc ccggcgagac cgtgaagatc     1320

agctgtaagg ccagcggcta cccctttacc aactatggaa tgaactgggt gaagcaagct     1380

cccggccagg gcctgaagtg gatgggctgg atcaacacaa gcaccggaga aagcaccttc     1440

gctgacgact tcaagggcag atttgacttc tccctcgaga cctccgccaa caccgcctac     1500

ctgcagatca acaatctgaa gtccgaggac agcgctacct acttctgcgc cagatgggag     1560

gtgtaccatg gctacgtccc ttattggggc caaggcacca ccgtgaccgt gagcagcgga     1620

ggaggcggtt ctggaggcgg cggcagcggc ggcggcggca gcgacattca gctgacccag     1680

tcccacaagt tcctgagcac ctccgtgggc gacagggtga gcattacctg caaggccagc     1740

caggacgtgt acaatgccgt ggcctggtac cagcagaagc ctggacagag ccccaagctg     1800

ctgatctaca gcgcttcctc caggtacacc ggcgtccctt ccagatttac cggctccggc     1860

tccggccccg acttcacctt caccatcagc tccgtgcagg ccgaagacct ggccgtgtac     1920

ttctgccaac agcacttcag gacccccttc acctttggca gcggaaccaa gctggagatc     1980

aaaaccacca cccccgcccc cagaccccct acacccgctc ccacaattgc ttcccagcct     2040

ctgagcctga ggcccgaggc ttgtaggcct gccgctggag gcgccgtgca tacaagaggc     2100

ctggacttcg cttgcgacat ctacatctgg gctcccctgg ccggcacatg tggagtgctc     2160

ctcctgagcc tggtgatcac actctactgc aagaggggca gaaagaagct gctctacatc     2220

ttcaagcagc ccttcatgag gcccgtgcag acaacccagg aggaggacgg ctgctcctgc     2280

agattccctg aggaggagga gggcggctgc gagctgagag tgaaattctc caggagcgcc     2340

gatgcccccg cctacaagca gggccaaaac cagctctaca acgagctgaa cctcggcagg     2400

agagaggagt atgatgtgct cgacaagagg aggggaaggg accccgaaat gggcggcaag     2460

cccaggagga agaaccccca ggaaggcctg tacaatgagc tgcagaagga caaaatggcc     2520

gaagcctata gcgagatcgg aatgaaaggc gagaggagga ggggcaaagg ccatgacggc     2580

ctgtatcagg gcctgagcac cgccacaaag gacacctacg acgccctcca catgcaggct     2640

ctgcccccta ggaat                                                      2655


<210>  18
<211>  2043
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Tet-on-HER2

<400>  18
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggggcagc     2040

ggc                                                                   2043


<210>  19
<211>  10
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ܵ

<400>  19
gcgcggccgc                                                              10


<210>  20
<211>  6
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ܵ

<400>  20
gccacc                                                                   6


<210>  21
<211>  102
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ܵNFAT

<400>  21
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt agatctagac tc                         102


<210>  22
<211>  112
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  IL2

<400>  22
cattttgaca cccccataat atttttccag aattaacagt ataaattgca tctcttgttc       60

aagagttccc tatcactctt taatcactac tcacagtaac ctcaactcct gc              112


<210>  23
<211>  204
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CMV

<400>  23
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  24
<211>  1461
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  4D5ScFv-CD8-CD137-CD3

<400>  24
atggccctgc ctgtgacagc cctgctcctg cctctcgccc tgctgctgca tgccgctaga       60

cctgaggttc agctggtgga gtctggcggt ggcctggtgc agccaggggg ctcactccgt      120

ttgtcctgtg cagcttctgg cttcaacatt aaagacacct atatacactg ggtgcgtcag      180

gccccgggta agggcctgga atgggttgca aggatttatc ctacgaatgg ttatactaga      240

tatgccgata gcgtcaaggg ccgtttcact ataagcgcag acacatccaa aaacacagcc      300

tacctgcaga tgaacagcct gcgtgctgag gacactgccg tctattattg ttctagatgg      360

ggaggggacg gcttctatgc tatggactac tggggtcaag gaaccctggt caccgtctcc      420

tcgggaggag gaggcagcgg cggaggaggc tccggcggcg gcggctctga catccagatg      480

acccagtccc cgagctccct gtccgcctct gtgggcgata gggttaccat cacctgccgt      540

gccagtcagg atgtgaatac tgctgtagcc tggtatcaac agaaaccagg aaaagctccg      600

aaactactga tttactcggc atccttcctc tactctggag tcccttctcg cttctctggt      660

tccagatctg ggacggattt cactctgacc atcagcagtc tgcagccgga agacttcgca      720

acttattact gtcagcaaca ttatactact cctcccacgt tcggacaggg taccaaggtg      780

gagatcaaaa ccaccacccc cgcccccaga ccccctacac ccgctcccac aattgcttcc      840

cagcctctga gcctgaggcc cgaggcttgt aggcctgccg ctggaggcgc cgtgcataca      900

agaggcctgg acttcgcttg cgacatctac atctgggctc ccctggccgg cacatgtgga      960

gtgctcctcc tgagcctggt gatcacactc tactgcaaga ggggcagaaa gaagctgctc     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

tcctgcagat tccctgagga ggaggagggc ggctgcgagc tgagagtgaa attctccagg     1140

agcgccgatg cccccgccta caagcagggc caaaaccagc tctacaacga gctgaacctc     1200

ggcaggagag aggagtatga tgtgctcgac aagaggaggg gaagggaccc cgaaatgggc     1260

ggcaagccca ggaggaagaa cccccaggaa ggcctgtaca atgagctgca gaaggacaaa     1320

atggccgaag cctatagcga gatcggaatg aaaggcgaga ggaggagggg caaaggccat     1380

gacggcctgt atcagggcct gagcaccgcc acaaaggaca cctacgacgc cctccacatg     1440

caggctctgc cccctaggaa t                                               1461


<210>  25
<211>  1458
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  FRP5ScFv-CD8-CD137-CD3

<400>  25
atggccctgc ctgtgacagc cctgctcctg cctctcgccc tgctgctgca tgccgctaga       60

cctcaggtcc agctgcagca gagcggaccc gagctcaaga agcccggcga gaccgtgaag      120

atcagctgta aggccagcgg ctaccccttt accaactatg gaatgaactg ggtgaagcaa      180

gctcccggcc agggcctgaa gtggatgggc tggatcaaca caagcaccgg agaaagcacc      240

ttcgctgacg acttcaaggg cagatttgac ttctccctcg agacctccgc caacaccgcc      300

tacctgcaga tcaacaatct gaagtccgag gacagcgcta cctacttctg cgccagatgg      360

gaggtgtacc atggctacgt cccttattgg ggccaaggca ccaccgtgac cgtgagcagc      420

ggaggaggcg gttctggagg cggcggcagc ggcggcggcg gcagcgacat tcagctgacc      480

cagtcccaca agttcctgag cacctccgtg ggcgacaggg tgagcattac ctgcaaggcc      540

agccaggacg tgtacaatgc cgtggcctgg taccagcaga agcctggaca gagccccaag      600

ctgctgatct acagcgcttc ctccaggtac accggcgtcc cttccagatt taccggctcc      660

ggctccggcc ccgacttcac cttcaccatc agctccgtgc aggccgaaga cctggccgtg      720

tacttctgcc aacagcactt caggaccccc ttcacctttg gcagcggaac caagctggag      780

atcaaaacca ccacccccgc ccccagaccc cctacacccg ctcccacaat tgcttcccag      840

cctctgagcc tgaggcccga ggcttgtagg cctgccgctg gaggcgccgt gcatacaaga      900

ggcctggact tcgcttgcga catctacatc tgggctcccc tggccggcac atgtggagtg      960

ctcctcctga gcctggtgat cacactctac tgcaagaggg gcagaaagaa gctgctctac     1020

atcttcaagc agcccttcat gaggcccgtg cagacaaccc aggaggagga cggctgctcc     1080

tgcagattcc ctgaggagga ggagggcggc tgcgagctga gagtgaaatt ctccaggagc     1140

gccgatgccc ccgcctacaa gcagggccaa aaccagctct acaacgagct gaacctcggc     1200

aggagagagg agtatgatgt gctcgacaag aggaggggaa gggaccccga aatgggcggc     1260

aagcccagga ggaagaaccc ccaggaaggc ctgtacaatg agctgcagaa ggacaaaatg     1320

gccgaagcct atagcgagat cggaatgaaa ggcgagagga ggaggggcaa aggccatgac     1380

ggcctgtatc agggcctgag caccgccaca aaggacacct acgacgccct ccacatgcag     1440

gctctgcccc ctaggaat                                                   1458


<210>  26
<211>  180
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ܵNFAT

<400>  26
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt      120

ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt      180


