                         SEQUENCE LISTING

<110>  Genesail Biotech (Shanghai) Co. Ltd.
 
<120>  A MODIFIED ONCOLYTIC VIRUS, COMPOSITION AND USE THEREOF

<130>  068615-8001WO02

<150>  PCT/CN2018/104830
<151>  2018-09-10

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  1

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser 
145                 150                 155                 160 


Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala 
                165                 170                 175     


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
            180                 185                 190         


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
        195                 200                 205             


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
    210                 215                 220                 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
225                 230                 235                 240 


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
                245                 250                 255     


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
            260                 265             


<210>  2
<211>  5
<212>  PRT
<213>  synthetic

<400>  2

Asn Ser Gly Met His 
1               5   


<210>  3
<211>  17
<212>  PRT
<213>  synthetic

<400>  3

Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  4
<212>  PRT
<213>  synthetic

<400>  4

Asn Asp Asp Tyr 
1               


<210>  5
<211>  113
<212>  PRT
<213>  synthetic

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  6
<211>  440
<212>  PRT
<213>  synthetic

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  7
<211>  339
<212>  DNA
<213>  synthetic

<400>  7
cgaacttacg gtcaccaatg tgccctgtcc ccagtaatcg tcgtttgtgg cgcagtagta       60

tacggctgtg tcctcagccc gcagtgaatt catctgtagg aacaatgtat ttttagagtt      120

gtccctacta atggtgaacc gtcccttcac agagtcggcg taataacgct tggagccgtc      180

ataccagata actgccaccc actccaagcc cttgcctggc gcttgccgta cccagtgcat      240

cccgctgtta gaaaaggtga tgccggaagc cttacagtcc aatcttagtg atctgcctgg      300

ctggacaact ccgccgcctg actcaaccag ctgtacttg                             339


<210>  8
<211>  890
<212>  DNA
<213>  synthetic

<400>  8
ctgacgaccc gataggttga attgaattgt tcctcgcggg gtttcgtctt tgcgttatgc       60

acttcaacgc cgtctacgta ccagttgaat tgcacttcgg gatcctcttg agagacatca      120

accacgacac aagtcacttc cggggtccgg ctaatcatta gggtgtcctt aggttttggt      180

gggaacagaa acacggacgg tccacccaag aactcggggg caggacacgg agggcagggg      240

ggtccatact tggattcgac ccgcttatct actttagtat tagagggctt gtggtcaacg      300

ttacaggtat aagttttcgt gcctagacta gatgaaggaa cagtgaccac ggaagatagt      360

gaatagaggc ccgagctctg cagcacggca gggaatgtgt gcactccaga ggtcagggcg      420

ccgctgttcc aggacacagt caccggttct ggaaagtagt ccttcacgag acatcctagc      480

gcagctgtgc tttcgcttgt gctcctactg cagggggcga gcgggaacac tgagggtccc      540

ttggtgcttg ccgaacttac ggtcaccaat gtgccctgtc cccagtaatc gtcgtttgtg      600

gcgcagtagt atacggctgt gtcctcagcc cgcagtgaat tcatctgtag gaacaatgta      660

tttttagagt tgtccctact aatggtgaac cgtcccttca cagagtcggc gtaataacgc      720

ttggagccgt cataccagat aactgccacc cactccaagc ccttgcctgg cgcttgccgt      780

acccagtgca tcccgctgtt agaaaaggtg atgccggaag ccttacagtc caatcttagt      840

gatctgcctg gctggacaac tccgccgcct gactcaacca gctgtacttg                 890


<210>  9
<211>  11
<212>  PRT
<213>  synthetic

<400>  9

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  synthetic

<400>  10

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  synthetic

<400>  11

Gln Gln Ser Ser Asn Trp Pro Arg Thr 
1               5                   


<210>  12
<211>  107
<212>  PRT
<213>  synthetic

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  214
<212>  PRT
<213>  synthetic

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  14
<211>  320
<212>  DNA
<213>  synthetic

<400>  14
gaaatcgtac tcacgcagtc ccctgctact ctgagtctct caccaggaga acgcgctacc       60

ctttcttgcc gtgcgtcaca gtcagtatcg tcctatctgg cttggtatca gcaaaaacca      120

ggtcaggccc cccgattatt gatttatgat gcatctaacc gggctacagg gattcctgcc      180

agatttagcg gtagcgggag tggaactgac ttcactctaa cattagctcc cttgagccag      240

aggatttcgc cgtctactac tgtcagcagt cttccaactg gcctcgtact ttcggacagg      300

gaacaaaggt ggaaatcaaa                                                  320


<210>  15
<211>  642
<212>  DNA
<213>  synthetic

<400>  15
gaaatcgtac tcacgcagtc ccctgctact ctgagtctct caccaggaga acgcgctacc       60

ctttcttgcc gtgcgtcaca gtcagtatcg tcctatctgg cttggtatca gcaaaaacca      120

ggtcaggccc cccgattatt gatttatgat gcatctaacc gggctacagg gattcctgcc      180

agatttagcg gtagcgggag tggaactgac ttcactctaa ccattagctc ccttgagcca      240

gaggatttcg ccgtctacta ctgtcagcag tcttccaact ggcctcgtac tttcggacag      300

ggaacaaagg tggaaatcaa acgtaccgtg gctgcaccca gcgtgttcat ttttccacca      360

agcgacgagc agctcaagag cggaaccgca tccgtagtat gtctcctcaa taacttctac      420

ccacgagaag ccaaagtgca gtggaaggtg gataatgcct tgcaatccgg aaacagccaa      480

gaaagcgtga ccgaacagga ttcaaaagac agcacctatt ctctgtccag cacattgaca      540

ctgagtaaag ctgattatga gaagcacaag gtctacgcgt gtgaggttac acatcaagga      600

ttgtcttcac cagtcaccaa gagtttcaat agaggagagt gc                         642


<210>  16
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala 
1               5                   10                  15      


Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro 
            20                  25                  30          


Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys 
        35                  40                  45              


Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr 
    50                  55                  60                  


Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly Ala 
65                  70                  75                  80  


Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr 
                85                  90                  95      


Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys 
            100                 105                 110         


Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser 
        115                 120                 125             


Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro Ser 
    130                 135                 140                 


Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala Pro 
145                 150                 155                 160 


Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu Ala 
                165                 170                 175     


Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg 
            180                 185                 190         


Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        195                 200                 205             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    210                 215                 220                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235             


<210>  17
<211>  5
<212>  PRT
<213>  synthetic

<400>  17

Gly Tyr Tyr Trp Ser 
1               5   


<210>  18
<211>  16
<212>  PRT
<213>  synthetic

<400>  18

Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu Ser 
1               5                   10                  15      


<210>  19
<211>  13
<212>  PRT
<213>  synthetic

<400>  19

Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10              


<210>  20
<211>  121
<212>  PRT
<213>  synthetic

<400>  20

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  448
<212>  PRT
<213>  synthetic

<400>  21

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  22
<211>  363
<212>  DNA
<213>  synthetic

<400>  22
caggttcagc tacagcagtg gggagcaggt ctgctgaaac caagcgaaac tttgtccttg       60

acgtgtgcag tctatggagg gtcctttagc ggttattatt ggtcctggat tagacagtcc      120

cctgagaagg ggctcgagtg gataggcgaa atcaatcatg gggggtatgt gacttacaat      180

ccctccctcg agtcccgggt aactatcagc gtggacactt cgaagaatca attttcacta      240

aagcttagtt ctgtcactgc tgctgataca gctgtctact attgtgcgcg tgattacgga      300

ccaggtaatt acgattggta tttcgacttg tgggggaggg gtaccttggt cacagtatca      360

tcc                                                                    363


<210>  23
<211>  1344
<212>  DNA
<213>  synthetic

<400>  23
caggttcagc tacagcagtg gggagcaggt ctgctgaaac caagcgaaac tttgtccttg       60

acgtgtgcag tctatggagg gtcctttagc ggttattatt ggtcctggat tagacagtcc      120

cctgagaagg ggctcgagtg gataggcgaa atcaatcatg gggggtatgt gacttacaat      180

ccctccctcg agtcccgggt aactatcagc gtggacactt cgaagaatca attttcacta      240

aagcttagtt ctgtcactgc tgctgataca gctgtctact attgtgcgcg tgattacgga      300

ccaggtaatt acgattggta tttcgacttg tgggggaggg gtaccttggt cacagtatca      360

tccgcaagta cgaagggccc ttccgtgttt ccactcgctc cctgcagtcg aagcacctca      420

gaatcaaccg ccgctctggg gtgtctcgtg aaggactact tcccggaacc tgtgaccgtc      480

agctggaact ccggggccct gacgagcgga gtgcacacct tccccgccgt gctccagagt      540

agtggacttt actccttatc ttccgtcgtc acagtgccta gttcatctct ggggaccaag      600

acatacactt gcaacgtgga ccataaacct tcaaacacga aagtcgataa acgcgtcgag      660

tctaaatacg gtcctccatg tccgccttgc cctgcccccg agtttctagg aggaccatca      720

gtctttcttt tcccaccaaa accgaaggac acgctcatga tttcacggac ccccgaagtg      780

acctgcgtgg tggtggacgt atcccaggag gatccagagg tgcagtttaa ttggtatgtg      840

gacggggtag aagttcataa cgctaaaacg aagcctcgcg aggaacaatt caatagtacc      900

tatagagtgg tgtcagtgct cactgtactg caccaggatt ggctcaacgg caaggagtac      960

aaatgtaagg tgtccaataa ggggctgccc agttctattg agaagacaat cagcaaggcg     1020

aagggccagc caagggagcc acaggtctat acactaccac caagccagga agagatgaca     1080

aagaaccagg tgtcactgac ttgtctggtc aagggctttt atccatctga tattgccgtg     1140

gagtgggagt ccaacggaca gccagagaac aactacaaga ccaccccccc cgtcctggac     1200

tctgacggct cattctttct gtatagcaga ctgaccgtgg ataagtctcg gtggcaggaa     1260

gggaacgtct tctcgtgcag cgtcatgcac gaggccctgc acaaccacta cacgcagaag     1320

tctctctcgc tttccctagg gaag                                            1344


<210>  24
<211>  11
<212>  PRT
<213>  synthetic

<400>  24

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  synthetic

<400>  25

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  26
<211>  11
<212>  PRT
<213>  synthetic

<400>  26

Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 
1               5                   10      


<210>  27
<211>  109
<212>  PRT
<213>  synthetic

<400>  27

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  28
<211>  327
<212>  PRT
<213>  synthetic

<400>  28

Thr Thr Thr Ala Ala Thr Thr Thr Cys Cys Ala Cys Cys Thr Thr Gly 
1               5                   10                  15      


Gly Thr Ala Cys Cys Ala Cys Cys Ala Cys Cys Gly Ala Ala Cys Gly 
            20                  25                  30          


Thr Cys Ala Gly Ala Gly Cys Gly Gly Gly Ala Gly Gly Cys Cys Ala 
        35                  40                  45              


Ala Thr Thr Ala Gly Ala Cys Cys Thr Cys Thr Gly Thr Thr Gly Ala 
    50                  55                  60                  


Cys Ala Ala Thr Ala Gly Thr Ala Ala Ala Cys Thr Gly Cys Gly Ala 
65                  70                  75                  80  


Ala Ala Thr Cys Cys Thr Cys Gly Gly Gly Thr Thr Cys Cys Ala Ala 
                85                  90                  95      


Cys Gly Ala Ala Cys Thr Ala Ala Thr Gly Gly Thr Cys Ala Gly Thr 
            100                 105                 110         


Gly Thr Gly Ala Ala Gly Thr Cys Gly Gly Thr Gly Cys Cys Gly Cys 
        115                 120                 125             


Thr Gly Cys Cys Gly Gly Ala Thr Cys Cys Gly Gly Ala Ala Ala Ala 
    130                 135                 140                 


Cys Cys Thr Gly Gly Cys Thr Gly Gly Gly Ala Thr Gly Cys Cys Gly 
145                 150                 155                 160 


Gly Thr Gly Gly Cys Cys Cys Gly Ala Thr Thr Gly Gly Ala Cys Gly 
                165                 170                 175     


Cys Gly Thr Cys Ala Thr Ala Gly Ala Thr Cys Ala Gly Thr Ala Gly 
            180                 185                 190         


Thr Cys Thr Gly Gly Gly Ala Gly Cys Cys Thr Gly Ala Cys Cys Cys 
        195                 200                 205             


Gly Gly Thr Thr Thr Cys Thr Gly Cys Thr Gly Ala Thr Ala Cys Cys 
    210                 215                 220                 


Ala Ala Gly Cys Cys Ala Gly Ala Thr Ala Thr Gly Ala Thr Gly Ala 
225                 230                 235                 240 


Ala Ala Cys Gly Cys Thr Cys Thr Gly Gly Gly Ala Thr Gly Cys Cys 
                245                 250                 255     


Cys Thr Gly Cys Ala Gly Gly Ala Thr Ala Ala Gly Gly Thr Thr Gly 
            260                 265                 270         


Cys Ala Cys Gly Cys Thr Cys Cys Cys Cys Thr Gly Gly Ala Gly Ala 
        275                 280                 285             


Cys Ala Gly Ala Cys Thr Cys Ala Gly Gly Gly Thr Thr Gly Cys Thr 
    290                 295                 300                 


Gly Gly Gly Gly Ala Cys Thr Gly Cys Gly Thr Cys Ala Gly Thr Ala 
305                 310                 315                 320 


Cys Thr Ala Thr Cys Thr Cys 
                325         


<210>  29
<211>  216
<212>  PRT
<213>  synthetic

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  30
<211>  648
<212>  DNA
<213>  synthetic

<400>  30
gcactcgcct cgattgaagc tcttagtaac ggggctggat aagccctggt gtgtcacttc       60

gcaggcatac accttatgtt tctcgtagtc ggccttactc agggtcaggg ttgaagaaag      120

tgaatacgta gaatctttgg agtcttgctc ggtcacgctc tcttgactat tcccgctctg      180

cagggcattg tccaccttcc attggacttt tgcctccctg gggtaaaagt tgttgaggag      240

acagacgacg ctcgccgtgc cggacttgag ctgttcgtca gatggaggga agatgaaaac      300

gctgggagcc gcgacggttc ttttaatttc caccttggta ccaccaccga acgtcagagc      360

gggaggccaa ttagacctct gttgacaata gtaaactgcg aaatcctcgg gttccaacga      420

actaatggtc agtgtgaagt cggtgccgct gccggatccg gaaaacctgg ctgggatgcc      480

ggtggcccga ttggacgcgt catagatcag tagtctggga gcctgacccg gtttctgctg      540

ataccaagcc agatatgatg aaacgctctg ggatgccctg caggataagg ttgcacgctc      600

ccctggagac agactcaggg ttgctgggga ctgcgtcagt actatctc                   648


<210>  31
<211>  30
<212>  DNA
<213>  synthetic

<400>  31
atggatcaca accagtatct cttaacgatg                                        30


<210>  32
<211>  30
<212>  DNA
<213>  synthetic

<400>  32
gaaatataga ttgttgtaga aatagtacct                                        30


<210>  33
<211>  24
<212>  DNA
<213>  synthetic

<400>  33
atatcgcatt ttctaacgtg atgg                                              24


<210>  34
<211>  24
<212>  DNA
<213>  synthetic

<400>  34
ggtttatcta acgacacaac atcc                                              24


<210>  35
<211>  24
<212>  DNA
<213>  synthetic

<400>  35
gatgcgattc aaaaaagaat cctc                                              24


<210>  36
<211>  24
<212>  DNA
<213>  synthetic

<400>  36
ggataaggtt gcacgctccc ctgg                                              24


<210>  37
<211>  24
<212>  DNA
<213>  synthetic

<400>  37
ctttactcct tatcttccgt cgtc                                              24


<210>  38
<211>  24
<212>  DNA
<213>  synthetic

<400>  38
gcaacgcttc gtgcatcacg gagc                                              24


<210>  39
<211>  24
<212>  DNA
<213>  synthetic

<400>  39
gtagtccttc acgagacatc ctag                                              24


<210>  40
<211>  24
<212>  DNA
<213>  synthetic

<400>  40
gccgtctact actgtcagca gtct                                              24


<210>  41
<211>  25
<212>  DNA
<213>  synthetic

<400>  41
tgtgtaccgg gagcagatcc tatat                                             25


<210>  42
<211>  24
<212>  DNA
<213>  synthetic

<400>  42
cggcgcagtg agtaatcaag gtca                                              24


<210>  43
<211>  24
<212>  DNA
<213>  synthetic

<400>  43
attagccgga ccccggaagt gact                                              24


<210>  44
<211>  24
<212>  DNA
<213>  synthetic

<400>  44
ggcttggtgg tagtgtatag acct                                              24


<210>  45
<211>  24
<212>  DNA
<213>  synthetic

<400>  45
accccccatg attgatttcg ccta                                              24


<210>  46
<211>  24
<212>  DNA
<213>  synthetic

<400>  46
ctccaaagat tctacgtatt cact                                              24


