                                        LISTAGEM DE SEQUNCIAS



<110>	OUROFINO SADE ANIMAL LTDA

<120>	POLIPEPTDEOS QUIMRICOS ANTIGNICOS, CONSTRUES GENTICAS QUIMRICAS CODIFICANTES DOS POLIPEPTDEOS E
	 COMPOSIO IMUNOGNICA PARA IMUNOCASTRAO DE MAMFEROS NO HUMANOS"

<130>	 0003/0153-PAT/KP/afr 

<160>	8

<210>   SEQ ID NO: 1
<211>   524  
<212>   PRT
<213>   Sequncia artifical

<220>
<223>	Construo anitgnica da vacina para imunocastrao  

<400>    1

Met   Gly   Gly   Gln   His   Trp   Ser   Tyr   Gly   Leu   Arg   Pro   Gly   Gly   Gly  
 1                      5                             10                            15
  
Gln   His   Trp   Ser   Tyr   Gly   Leu   Arg   Pro   Gly   Gly   Gln   His   Trp   Ser  
                        20                            25                            30

  
Tyr   Gly   Leu   Arg   Pro   Gly   Ser   Ile   Gly   Ala   Ala   Ser   Met   Glu   Phe
                        35                            40                            45
    
Cys   Phe   Asp   Val   Phe   Lys   Glu   Leu   Lys   Val   His   His   Ala   Asn   Glu  
                        50                            55                            60
  
Asn   Ile   Phe   Tyr   Cys   Pro   Ile   Ala   Ile   Met   Ser   Ala   Leu   Ala   Met   
                        65                            70                            75
 
Val   Tyr   Leu   Gly   Ala   Lys   Asp   Ser   Thr   Arg   Thr   Gln   Ile   Asn   Lys   
                        80                            85                            90
 
Val   Val   Arg   Phe   Asp   Lys   Leu   Gly   Gly   Gln   His   Trp   Ser   Tyr   Gly  
                        95                            100                           105
  
Leu   Arg   Pro   Gly   Phe   Gly   Gly   Gly   Gln   His   Trp   Ser   Tyr   Gly   Leu 
                        110                           115                           120
   
Arg   Pro   Gly   Asp   Ser   Ile   Glu   Ala   Gln   Cys   Gly   Gly   Gln   His   Trp  
                        125                           130                           135
  
Ser   Tyr   Gly   Leu   Arg   Pro   Gly   Thr   Ser   Val   Asn   Val   His   Ser   Ser    
                        140                           145                           150

Leu   Arg   Asp   Ile   Leu   Asn   Gln   Ile   Thr   Lys   Pro   Asn   Asp   Val   Tyr 
                        155                           160                           165
   
Ser   Phe   Ser   Leu   Ala   Ser   Arg   Leu   Tyr   Ala   Glu   Glu   Arg   Tyr   Pro 
                        170                           175                           180
   
Ile   Leu   Pro   Glu   Tyr   Leu   Gln   Cys   Val   Lys   Glu   Leu   Tyr   Arg   Gly  
                        185                           190                           195
  
Gly   Leu   Glu   Pro   Ile   Asn   Phe   Gln   Thr   Ala   Ala   Asp   Gln   Ala   Arg   
                        200                           205                           210
 
Glu   Leu   Ile   Asn   Ser   Trp   Val   Glu   Ser   Gln   Thr   Asn   Gly   Ile   Ile    
                        215                           220                           225

Arg   Asn   Val   Leu   Gln   Pro   Ser   Ser   Val   Asp   Ser   Gln   Thr   Ala   Met    
                        230                           235                           240

Val   Leu   Val   Asn   Ala   Ile   Val   Phe   Lys   Gly   Leu   Trp   Glu   Lys   Ala   
                        245                           250                           255
 
Phe   Lys   Asp   Glu   Asp   Thr   Gln   Ala   Met   Pro   Phe   Arg   Val   Thr   Glu   
                        260                           265                           270
 
Gln   Glu   Ser   Lys   Pro   Val   Gln   Met   Met   Tyr   Gln   Ile   Gly   Leu   Phe   
                        275                           280                           285
 
Arg   Val   Ala   Ser   Met   Ala   Ser   Glu   Lys   Met   Lys   Ile   Leu   Glu   Leu    
                        290                           295                           300

Pro   Phe   Ala   Ser   Gly   Thr   Met   Ser   Met   Leu   Val   Leu   Leu   Pro   Asp   
                        305                           310                           315
 
Glu   Val   Ser   Gly   Leu   Glu   Gln   Leu   Glu   Ser   Ile   Ile   Asn   Phe   Glu  
                        320                           325                           330
  
Lys   Leu   Thr   Glu   Trp   Thr   Ser   Ser   Asn   Val   Met   Glu   Glu   Arg   Lys 
                        335                           340                           345
   
Ile   Lys   Val   Tyr   Leu   Pro   Arg   Met   Lys   Met   Glu   Glu   Lys   Tyr   Asn 
                        350                           355                           360
   
Leu   Thr   Ser   Val   Leu   Met   Ala   Met   Gly   Ile   Thr   Asp   Val   Phe   Ser 
                        365                           370                           375
   
Ser   Ser   Ala   Asn   Leu   Ser   Gly   Ile   Ser   Ser   Ala   Glu   Ser   Leu   Lys 
                        380                           385                           390
   
Ile   Ser   Gln   Ala   Val   His   Ala   Ala   His   Ala   Glu   Ile   Asn   Glu   Ala 
                        395                           400                           405
   
Gly   Arg   Glu   Val   Val   Gly   Ser   Ala   Glu   Ala   Gly   Val   Asp   Ala   Ala  
                        410                           415                           420
  
Ser   Val   Ser   Glu   Glu   Phe   Arg   Ala   Asp   His   Pro   Phe   Leu   Phe   Cys  
                        425                           430                           435
  
Ile   Lys   His   Ile   Ala   Thr   Asn   Ala   Val   Leu   Phe   Phe   Gly   Arg   Cys 
                        440                           445                           450
   
Val   Ser   Pro   Gly   Gly   Gly   Gly   Ser   Gly   Gly   Gly   Gly   Ser   Ala   Leu  
                        455                           460                           465
  
Asn   Asn   Arg   Phe   Gln   Ile   Lys   Gly   Val   Glu   Leu   Lys   Ser   Gly   Gly  
                        470                           475                           480
  
Gln   His   Trp   Ser   Tyr   Gly   Leu   Arg   Pro   Gly   Gly   Gln   His   Trp   Ser 
                        485                           490                           495                 
   
Tyr   Gly   Leu   Arg   Pro   Gly   Gly   Gln   His   Trp   Ser   Tyr   Gly   Leu   Arg  
                        500                           505                           510
  
Pro   Gly   Gly   Gly   Gln   His   Trp   Ser   Tyr   Gly   Leu   Arg   Pro   Gly 
                        515                           520                     524


<210>   SEQ ID NO: 2
<211>   514  
<212>   PRT
<213>   Sequncia artifical

<220>
<223>	Construo anitgnica da vacina para imunocastrao  

<400>    2

Met Gly Gly His Trp Ser Tyr Gly Leu Arg Pro Gly Gly Gly His Trp Ser Tyr Gly Leu
 1               5                   10                 15                  20

Arg Pro Gly Gly His Trp Ser Tyr Gly Leu Arg Pro Gly Ser Ile Gly Ala Ala Ser Met
                25                  30                   35                 40

Glu Phe Cys Phe Asp Val Phe Lys Glu Leu Lys Val His His Ala Asn Glu Asn Ile Phe
                45                   50                  55                  60

Tyr Cys Pro Ile Ala Ile Met Ser Ala Leu Ala Met Val Tyr Leu Gly Ala Lys Asp Ser
                65                   70                  75                  80

Thr Arg Thr Gln Ile Asn Lys Val Val Arg Phe Asp Lys Leu Gly Gly His Trp Ser Tyr
                85                   90                  95                 100

Gly Leu Arg Pro Gly Phe Gly Gly Gly His Trp Ser Tyr Gly Leu Arg Pro Gly Asp Ser
                105                 110                 115                 120

Ile Glu Ala Gln Cys Gly Gly His Trp Ser Tyr Gly Leu Arg Pro Gly Thr Ser Val Asn
                125                 130                 135                 140

Val His Ser Ser Leu Arg Asp Ile Leu Asn Gln Ile Thr Lys Pro Asn Asp Val Tyr Ser
                145                 150                 155                 160

Phe Ser Leu Ala Ser Arg Leu Tyr Ala Glu Glu Arg Tyr Pro Ile Leu Pro Glu Tyr Leu
                165                 170                 175                 180

Gln Cys Val Lys Glu Leu Tyr Arg Gly Gly Leu Glu Pro Ile Asn Phe Gln Thr Ala Ala
                185                 190                 195                 200

Asp Gln Ala Arg Glu Leu Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Gly Ile Ile Arg
                205                 210                 215                 220

Asn Val Leu Gln Pro Ser Ser Val Asp Ser Gln Thr Ala Met Val Leu Val Asn Ala Ile
                225                 230                 235                 240

Val Phe Lys Gly Leu Trp Glu Lys Ala Phe Lys Asp Glu Asp Thr Gln Ala Met Pro Phe
                245                 250                 255                 260

Arg Val Thr Glu Gln Glu Ser Lys Pro Val Gln Met Met Tyr Gln Ile Gly Leu Phe Arg
                265                 270                 275                 280

Val Ala Ser Met Ala Ser Glu Lys Met Lys Ile Leu Glu Leu Pro Phe Ala Ser Gly Thr
                285                 290                 295                 300

Met Ser Met Leu Val Leu Leu Pro Asp Glu Val Ser Gly Leu Glu Gln Leu Glu Ser Ile
                305                 310                 315                 320

Ile Asn Phe Glu Lys Leu Thr Glu Trp Thr Ser Ser Asn Val Met Glu Glu Arg Lys Ile
                325                 330                 335                 340

Lys Val Tyr Leu Pro Arg Met Lys Met Glu Glu Lys Tyr Asn Leu Thr Ser Val Leu Met
                345                 350                 355                 360

Ala Met Gly Ile Thr Asp Val Phe Ser Ser Ser Ala Asn Leu Ser Gly Ile Ser Ser Ala
                365                 370                 375                 380

Glu Ser Leu Lys Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly
                385                 390                 395                 400

Arg Glu Val Val Gly Ser Ala Glu Ala Gly Val Asp Ala Ala Ser Val Ser Glu Glu Phe
                405                 410                 415                 420

Arg Ala Asp His Pro Phe Leu Phe Cys Ile Lys His Ile Ala Thr Asn Ala Val Leu Phe
                425                 430                 435                 440

Phe Gly Arg Cys Val Ser Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Asn
                445                 450                 455                 460

Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Gly His Trp Ser Tyr Gly Leu
                465                 470                 475                 480

Arg Pro Gly Gly His Trp Ser Tyr Gly Leu Arg Pro Gly Gly His Trp Ser Tyr Gly Leu
                485                 490                 495                 500

Arg Pro Gly Gly Gly His Trp Ser Tyr Gly Leu Arg Pro Gly
                505                 510             514   


<210>   SEQ ID NO:3
<211>   1578  
<212>   DNA
<213>   Sequncia artifical

<220>
<223>	Sequncia de DNA codificante do antgeno da vacina para imunocastrao  

<400>    3

ATGGGTGGTC  AGCATTGGTC  TTATGGTCTG  CGTCCGGGTG  GCGGTCAGCA  TTGGTCTTAT    60
GGCCTCCGCC  CGGGTGGCCA  ACACTGGAGT  TACGGCCTCC  GTCCGGGTAG  CATCGGCGCG    120
GCGTCTATGG  AATTCTGCTT  TGACGTGTTT  AAAGAACTGA  AGGTCCATCA  CGCCAACGAA    180
AACATCTTCT  ACTGTCCGAT  CGCCATCATG  AGCGCGCTGG  CAATGGTATA  TCTGGGCGCG    240
AAAGATTCCA  CGCGTACGCA  GATTAACAAA  GTTGTTCGTT  TCGACAAACT  GGGCGGCCAA    300
CATTGGAGCT  ACGGCCTTCG  CCCGGGCTTC  GGCGGTGGTC  AACACTGGTC  ATACGGCCTG    360
AGGCCTGGCG  ATAGCATCGA  GGCGCAGTGC  GGCGGTCAAC  ATTGGTCCTA  TGGTTTACGT    420
CCGGGTACCA  GCGTGAATGT  GCACAGCAGC  CTGCGTGATA  TTCTGAATCA  GATCACGAAG    480
CCGAACGATG  TGTATAGCTT  TAGCCTGGCG  AGCCGTCTGT  ACGCTGAGGA  ACGTTATCCG    540
ATTTTGCCAG  AGTATTTGCA  GTGTGTCAAA  GAACTGTACC  GTGGTGGCCT  GGAGCCAATT    600
AACTTTCAAA  CCGCGGCGGA  CCAGGCACGT  GAACTGATCA  ACAGCTGGGT  TGAAAGCCAG    660
ACGAATGGTA  TCATTCGTAA  TGTGCTGCAG  CCGAGCAGCG  TTGACAGCCA  AACCGCAATG    720
GTGCTGGTTA  ACGCTATTGT  CTTTAAGGGT  CTGTGGGAAA  AAGCATTCAA  AGACGAAGAT    780
ACCCAAGCGA  TGCCGTTCCG  TGTCACGGAG  CAGGAAAGCA  AGCCTGTTCA  GATGATGTAC    840
CAAATCGGTC  TGTTCCGTGT  GGCTTCGATG  GCCTCTGAGA  AAATGAAAAT  CCTGGAACTT    900
CCGTTTGCTT  CGGGTACCAT  GTCCATGCTG  GTGCTGTTGC  CGGACGAAGT  TAGCGGCCTG    960
GAGCAATTGG  AATCCATCAT  CAATTTTGAA  AAGCTGACTG  AGTGGACCAG  CTCTAACGTG    1020
ATGGAGGAAC  GTAAGATTAA  GGTCTATCTG  CCGCGCATGA  AAATGGAAGA  GAAGTACAAC    1080
CTGACCAGCG  TGCTGATGGC  CATGGGTATT  ACCGACGTTT  TTAGCAGCAG  CGCCAATCTG    1140
AGCGGTATTT  CCAGCGCGGA  GAGCCTGAAG  ATTAGCCAAG  CGGTTCACGC  TGCGCACGCC    1200
GAGATTAATG  AGGCCGGTCG  TGAAGTTGTT  GGTAGCGCCG  AGGCTGGTGT  CGACGCCGCG    1260
TCTGTTTCTG  AAGAGTTTCG  CGCAGATCAC  CCGTTCCTGT  TCTGCATCAA  ACATATCGCT    1320
ACCAACGCAG  TGCTGTTTTT  CGGTCGCTGT  GTTAGCCCGG  GTGGTGGCGG  CTCCGGCGGC    1380
GGCGGCTCTG  CCCTGAATAA  CCGCTTTCAG  ATTAAGGGCG  TTGAACTGAA  AAGCGGTGGC    1440
CAGCACTGGT  CCTACGGTCT  GCGCCCGGGG  GGCCAGCACT  GGTCTTACGG  CCTGCGCCCA    1500
GGCGGCCAGC  ACTGGTCGTA  CGGCTTGCGT  CCGGGCGGTG  GCCAACACTG  GAGCTATGGT    1560
TTGCGCCCGG  GTTAATAA    1578

<210>   SEQ ID NO: 4
<211>   1548  
<212>   DNA
<213>   Sequncia artifical

<220>
<223>	Sequncia de DNA codificante do antgeno da vacina para imunocastrao  

<400>    4

ATGGGTGGTC ATTGGTCTTA CGGTCTGCGT CCTGGTGGTG GTCATTGGAG CTATGGTTTG  60
CGTCCGGGCG GTCACTGGTC ATATGGCCTG CGTCCAGGTA GCATCGGTGC AGCGTCTATG  120
GAATTTTGTT TTGATGTGTT TAAAGAACTG AAAGTGCACC ATGCTAATGA GAATATCTTC  180
TACTGCCCGA TCGCGATTAT GTCTGCCCTG GCGATGGTCT ATTTGGGCGC TAAAGACTCC  240
ACTCGTACCC AGATTAATAA AGTTGTTCGT TTTGACAAAC TGGGTGGCCA TTGGAGTTAT  300
GGCTTGCGTC CAGGCTTCGG CGGCGGGCAT TGGTCCTACG GCTTGCGCCC AGGTGACAGC  360
ATCGAAGCGC AGTGCGGCGG CCACTGGTCT TATGGTCTGC GCCCGGGCAC GAGCGTGAAT  420
GTGCACAGCT CCCTGCGTGA CATTTTGAAC CAGATCACGA AGCCGAACGA TGTTTACAGC  480
TTTAGCCTGG CATCACGTCT GTACGCCGAA GAGAGATATC CGATCCTGCC TGAGTATCTG  540
CAGTGCGTCA AAGAACTGTA TCGCGGTGGT CTTGAGCCGA TTAATTTCCA AACCGCAGCA  600
GACCAGGCGC GTGAGCTGAT TAATAGCTGG GTTGAGAGCC AAACCAACGG CATTATCCGT  660
AATGTCTTAC AGCCGAGCAG CGTTGACTCG CAGACCGCGA TGGTCCTGGT CAACGCAATT  720
GTCTTTAAGG GTCTGTGGGA AAAGGCGTTT AAAGACGAAG ATACCCAGGC CATGCCGTTT  780
CGCGTTACGG AGCAAGAAAG CAAACCGGTT CAAATGATGT ACCAGATTGG CCTGTTTCGT  840
GTGGCGAGCA TGGCGAGCGA GAAGATGAAA ATTCTGGAAC TGCCGTTCGC GAGCGGTACC  900
ATGAGCATGC TGGTGCTGCT GCCGGATGAA GTCAGCGGCC TGGAGCAACT GGAAAGCATC  960
ATCAACTTCG AAAAACTGAC CGAGTGGACC AGCAGCAATG TTATGGAGGA ACGTAAAATT  1020
AAAGTTTACT TGCCGCGCAT GAAGATGGAA GAAAAGTACA ATTTGACGTC CGTTCTGATG  1080
GCAATGGGCA TCACCGATGT GTTTTCTAGC AGCGCCAACT TGAGCGGTAT CAGCAGCGCA  1140
GAGAGCCTGA AGATCAGCCA AGCCGTACAC GCCGCGCACG CCGAGATTAA TGAAGCGGGT  1200
CGTGAAGTCG TGGGTAGCGC AGAGGCTGGT GTCGATGCCG CGTCCGTGTC CGAAGAATTT  1260
CGCGCGGACC ATCCGTTCCT GTTTTGCATC AAGCATATTG CTACGAACGC AGTGCTGTTC  1320
TTTGGCCGCT GTGTGTCCCC GGGTGGTGGC GGCAGCGGTG GCGGTGGCAG CGCCCTGAAT  1380
AATCGTTTTC AGATCAAGGG CGTTGAGCTG AAGTCCGGTG GCCACTGGAG CTACGGCCTG  1440
CGCCCTGGCG GTCATTGGTC TTACGGTTTG CGCCCGGGTG GTCACTGGTC GTACGGCTTA  1500
CGTCCGGGTG GCGGCCATTG GTCATACGGC CTTCGTCCGG GTTGATAA  1548


<210>   SEQ ID NO: 5
<211>   10  
<212>   PRT
<213>   Sequncia artifical

<220>
<223>	Sequncia espaadora  

<400>    5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10


<210>   SEQ ID NO: 6
<211>   15  
<212>   PRT
<213>   Vrus da Influenza A

<220>
<223>	Eptopo T-auxiliar de hemaglutinina do vrus da Influenza A (Sequncia recurtadora de eptopos)

<400>    6

Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser
 1               5                   10                  15 


<210>   SEQ ID NO: 7
<211>   10  
<212>   PRT
<213>   Sequncia artifical

<220>
<223>	Decapeptdeo GNrH

<400>   7


Gln His Trp Ser Tyr Gly Leu Arg Pro Gly
 1		 5		 9


<210>   SEQ ID NO: 8
<211>   9  
<212>   PRT
<213>   Sequncia artifical

<220>
<223>	Anlogo do decapeptdeo GNrH

<400>   8

Gly His Trp Ser Tyr Gly Leu Arg Pro Gly
 1               5               9