                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> RNA AND DNA BASE EDITING VIA ENGINEERED ADAR RECRUITMENT

<130> 00015-365WO1

<140> PCT/US2019/050095
<141> 2019-09-06

<150> 62/780,241
<151> 2018-12-15

<150> 62/766,433
<151> 2018-10-17

<150> 62/728,007
<151> 2018-09-06

<160> 255   

<170> PatentIn version 3.5

<210> 1
<211> 323
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (117)..(146)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (148)..(176)
<223> a, c, t, g, unknown or other

<400> 1
ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcggggaga       60

ttgcttgagc ccaggagttc gagaccagcc tgggcaacat agcgagaccc cgtctcnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnncnnn nnnnnnnnnn nnnnnnnnnn nnnnnnagcc      180

gggcgtggtg gcgcgcgcct gtagtcccag ctactcggga ggctgaggca ggaggatcgc      240

ttgagcccag gagttcgagg ctgcagtgag ctatgatcgc gccactgcac tccagcctgg      300

gcgacagagc gagaccctgt ctc                                              323


<210> 2
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (46)..(51)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (53)..(66)
<223> a, c, t, g, unknown or other

<400> 2
gtggaagagg agaacaatat gctaaatgtt gttctcgtct cccacnnnnn ncnnnnnnnn       60

nnnnnn                                                                  66


<210> 3
<211> 68
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (50)..(52)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (54)..(68)
<223> a, c, t, g, unknown or other

<400> 3
gggtggaaga ggagaacaat atgctaaatg ttgttctcgt ctcccacctn nncnnnnnnn       60

nnnnnnnn                                                                68


<210> 4
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (46)..(51)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (53)..(66)
<223> a, c, t, g, unknown or other

<400> 4
ggtgaagagg agaacaatat gctaaatgtt gttctcgtct ccaccnnnnn ncnnnnnnnn       60

nnnnnn                                                                  66


<210> 5
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (46)..(52)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (54)..(66)
<223> a, c, t, g, unknown or other

<400> 5
ggtgaagagg agaacaatat gctaaatgtt gttctcgtct ccaccnnnnn nncnnnnnnn       60

nnnnnn                                                                  66


<210> 6
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (46)..(51)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (53)..(66)
<223> a, c, t, g, unknown or other

<400> 6
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccacnnnnn ncnnnnnnnn       60

nnnnnn                                                                  66


<210> 7
<211> 68
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (50)..(52)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (54)..(68)
<223> a, c, t, g, unknown or other

<400> 7
gggtggaaga ggagaacaat aggctaaacg ttgttctcgt ctcccacctn nncnnnnnnn       60

nnnnnnnn                                                                68


<210> 8
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (46)..(51)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (53)..(66)
<223> a, c, t, g, unknown or other

<400> 8
ggtgaagagg agaacaatag gctaaacgtt gttctcgtct ccaccnnnnn ncnnnnnnnn       60

nnnnnn                                                                  66


<210> 9
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (46)..(52)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (54)..(66)
<223> a, c, t, g, unknown or other

<400> 9
ggtgaagagg agaacaatag gctaaacgtt gttctcgtct ccaccnnnnn nncnnnnnnn       60

nnnnnn                                                                  66


<210> 10
<211> 312
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcggggaga       60

ttgcttgagc ccaggagttc gagaccagcc tgggcaacat agcgagaccc cgtctctaca      120

aaaaatacaa aaattagccg ggcgtggtgg cgcgcgcctg tagtcccagc tactcgggag      180

gctgaggcag gaggatcgct tgagcccagg agttcgaggc tgcagtgagc tatgatcgcg      240

ccactgcact ccagcctggg cgacagagcg agaccctgtc tcaaaaaaaa aaaaaaaaaa      300

aaaaaaaaaa aa                                                          312


<210> 11
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (117)..(216)
<223> a, c, t, g, unknown or other

<400> 11
ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcggggaga       60

ttgcttgagc ccaggagttc gagaccagcc tgggcaacat agcgagaccc cgtctcnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnagcc gggcgtggtg gcgcgcgcct      240

gtagtcccag ctactcggga ggctgaggca ggaggatcgc ttgagcccag gagttcgagg      300

ctgcagtgag ctatgatcgc gccactgcac tccagcctgg gcgacagagc gagaccctgt      360

ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                   393


<210> 12
<211> 68
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (50)..(52)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (54)..(68)
<223> a, c, u, g, unknown or other

<400> 12
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccun nncnnnnnnn       60

nnnnnnnn                                                                68


<210> 13
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (46)..(51)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (53)..(66)
<223> a, c, u, g, unknown or other

<400> 13
guggaauagu auaacaauau gcuaaauguu guuauaguau cccacnnnnn ncnnnnnnnn       60

nnnnnn                                                                  66


<210> 14
<211> 76
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (56)..(61)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (63)..(76)
<223> a, c, u, g, unknown or other

<400> 14
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acaccnnnnn       60

ncnnnnnnnn nnnnnn                                                       76


<210> 15
<211> 117
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
aacuuugugc auuuuagguc ucaaguggau auucauggug ucuaugaauu cacuaaaaga       60

ugucagugcc uggugaaauc auauacacca uggagaggcu auaaaaugca gaagguu         117


<210> 16
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
aaccgagcgg tgtctgtga                                                    19


<210> 17
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
aaccgagcgg tgtctgtga                                                    19


<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
aaccgagcgg tgtctgtga                                                    19


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
acaaaccgag cggtgtctgt g                                                 21


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
acaaaccgag cggtgtctgt g                                                 21


<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
acaaaccgag cggtgtctgt g                                                 21


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
acaaaccgag cggtgtctgt g                                                 21


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
tacaaaccga gcggtgtctg t                                                 21


<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
acaaaccgag cggtgtctgt g                                                 21


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
tacaaaccga gcggtgtctg t                                                 21


<210> 26
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
tacaaaccga gcggtgtc                                                     18


<210> 27
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
tacaaaccga gcggtgtc                                                     18


<210> 28
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
tacaaaccga gcggtgtc                                                     18


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
caaaccgagc ggtgtctgtg                                                   20


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
tacaaaccga gcggtgtctg                                                   20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
tttacaaacc gagcggtgtc                                                   20


<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
acaaaccgag cggtgtctgt g                                                 21


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
acaaaccgag cggtgtctgt g                                                 21


<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
acaaaccgag cggtgtctgt g                                                 21


<210> 35
<211> 120
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (46)..(59)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (61)..(75)
<223> a, c, u, g, unknown or other

<400> 35
guggaauagu auaacaauau gcuaaauguu guuauaguau cccacnnnnn nnnnnnnnnc       60

nnnnnnnnnn nnnnncaccc uaugauauug uuguaaaucg uauaacaaua ugauaaggug      120


<210> 36
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(14)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (16)..(30)
<223> a, c, u, g, unknown or other

<400> 36
nnnnnnnnnn nnnncnnnnn nnnnnnnnnn                                        30


<210> 37
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (46)..(51)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (53)..(66)
<223> a, c, u, g, unknown or other

<400> 37
guggaauagu auaacaauau gcuaaauguu guuauaguau cccacnnnnn ncnnnnnnnn       60

nnnnnn                                                                  66


<210> 38
<211> 283
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcggggaga       60

ttgcttgagc ccaggagttc gagaccagcc tgggcaacat agcgagaccc cgtctcatac      120

tgccgccagc tggattagcc gggcgtggtg gcgcgcgcct gtagtcccag ctactcggga      180

ggctgaggca ggaggatcgc ttgagcccag gagttcgagg ctgcagtgag ctatgatcgc      240

gccactgcac tccagcctgg gcgacagagc gagaccctgt ctc                        283


<210> 39
<211> 303
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcggggaga       60

ttgcttgagc ccaggagttc gagaccagcc tgggcaacat agcgagaccc cgtctcactg      120

tacagaatac tgccgccagc tggatttccc aattctagcc gggcgtggtg gcgcgcgcct      180

gtagtcccag ctactcggga ggctgaggca ggaggatcgc ttgagcccag gagttcgagg      240

ctgcagtgag ctatgatcgc gccactgcac tccagcctgg gcgacagagc gagaccctgt      300

ctc                                                                    303


<210> 40
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 40
ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcggggaga       60

ttgcttgagc ccaggagttc gagaccagcc tgggcaacat agcgagaccc cgtctctctt      120

gtgtctactg tacagaatac tgccgccagc tggatttccc aattctgagt aacacagccg      180

ggcgtggtgg cgcgcgcctg tagtcccagc tactcgggag gctgaggcag gaggatcgct      240

tgagcccagg agttcgaggc tgcagtgagc tatgatcgcg ccactgcact ccagcctggg      300

cgacagagcg agaccctgtc tc                                               322


<210> 41
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcggggaga       60

ttgcttgagc ccaggagttc gagaccagcc tgggcaacat agcgagaccc cgtctctgat      120

aaaaggcgta cataattctt gtgtctactg tacagaatac tgccgccagc tggatttccc      180

aattctgagt aacactctgc aatccaaaca gggttcagcc gggcgtggtg gcgcgcgcct      240

gtagtcccag ctactcggga ggctgaggca ggaggatcgc ttgagcccag gagttcgagg      300

ctgcagtgag ctatgatcgc gccactgcac tccagcctgg gcgacagagc gagaccctgt      360

ctc                                                                    363


<210> 42
<211> 386
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Gln Leu His Leu Pro Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val 
1               5                   10                  15      


Leu Gly Lys Phe Gly Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala 
            20                  25                  30          


Arg Arg Lys Val Leu Ala Gly Val Val Met Thr Thr Gly Thr Asp Val 
        35                  40                  45              


Lys Asp Ala Lys Val Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn 
    50                  55                  60                  


Gly Glu Tyr Met Ser Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala 
65                  70                  75                  80  


Glu Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu 
                85                  90                  95      


Glu Leu Tyr Leu Asn Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln 
            100                 105                 110         


Lys Ser Glu Arg Gly Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His 
        115                 120                 125             


Leu Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro 
    130                 135                 140                 


His Glu Pro Ile Ile Glu Glu Pro Ala Asp Arg His Pro Asn Arg Lys 
145                 150                 155                 160 


Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile 
                165                 170                 175     


Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln 
            180                 185                 190         


Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp 
        195                 200                 205             


Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro 
    210                 215                 220                 


Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His 
225                 230                 235                 240 


Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro 
                245                 250                 255     


Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala 
            260                 265                 270         


Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr 
        275                 280                 285             


Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp 
    290                 295                 300                 


Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg 
305                 310                 315                 320 


Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys 
                325                 330                 335     


Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu 
            340                 345                 350         


Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly 
        355                 360                 365             


Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu 
    370                 375                 380                 


Thr Pro 
385     


<210> 43
<211> 1662
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 43
atgaagacct taattcttgc cgttgcatta gtctactgcg ccactgttca ttgccaggac       60

tgtccttacg aacctgatcc accaaacaca gttccaactt cctgtgaagc taaagaagga      120

gaatgtattg atagcagctg tggcacctgc acgagagaca tactatcaga tggactgtgt      180

gaaaataaac caggaaaaac atgttgccga atgtgtcagt atgtaattga atgcagagta      240

gaggccgcag gatagtttag aacattctat ggaaagagat tccagttcca ggaacctggt      300

acatacgtgt tgggtcaagg aaccaagggc ggcgactgga aggtgtccat caccctggag      360

aacctggatg gaaccaaggg ggctgtgctg accaagacaa gactggaagt ggctggagac      420

atcattgaca tcgctcaagc tactgagaat cccatcactg taaacggtgg agctgaccct      480

atcatcgcca acccgtacac catcggcgag gtcaccatcg ctgttgttga gatgccaggc      540

ttcaacatca ccgtcattga gttcttcaaa ctgatcgtga tcgacatcct cggaggaaga      600

tctgtaagaa tcgccccaga cacagcaaac aaaggaatga tctctggcct ctgtggagat      660

cttaaaatga tggaagatac agacttcact tcagatccag aacaactcgc tattcagcct      720

aagatcaacc aggagtttga cggttgtcca ctctatggaa atcctgatga cgttgcatac      780

tgcaaaggtc ttctggagcc gtacaaggac agctgccgca accccatcaa cttctactac      840

tacaccatct cctgcgcctt cgcccgctgt atgggtggag acgagcgagc ctcacacgtg      900

ctgcttgact acagggagac gtgcgctgct cccgaaacta gaggaacctg cgttttgtct      960

ggacatactt tctacgatac atttgacaaa gcaagatacc aattccaggg tccctgcaag     1020

gagattctta tggccgccga ctgtttctgg aacacttggg atgtgaaggt ttcacacagg     1080

aatgttgact cttacactga agtagagaaa gtacgaatca ggaaacaatc gactgtagta     1140

gaactcattg ttgatggaaa acagattctg gttggaggag aagccgtgtc cgtcccgtac     1200

agctctcaga acacttccat ctactggcaa gatggtgaca tactgactac agccatccta     1260

cctgaagctc tggtggtcaa gttcaacttc aagcaactgc tcgtcgtaca tattagagat     1320

ccattcgatg gtaagacttg cggtatttgc ggtaactaca accaggattt cagtgatgat     1380

tcttttgatg ctgaaggagc ctgtgatctg acccccaacc caccgggatg caccgaagaa     1440

cagaaacctg aagctgaacg actctgcaat agtctcttcg ccggtcaaag tgatcttgat     1500

cagaaatgta acgtgtgcca caagcctgac cgtgtcgaac gatgcatgta cgagtattgc     1560

ctgaggggac aacagggttt ctgtgaccac gcatgggagt tcaagaaaga atgctacata     1620

aagcatggag acaccctaga agtaccagat gaatgcaaat aa                        1662


<210> 44
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
ggccctgaaa aagggcctgt tctaaaccat cctgcggcct caacatgagg atcacccatg       60

c                                                                       61


<210> 45
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
aacatgagga tcacccatgt cctaaaccat cctgcggcct ctactctggc cctgaaaaag       60

ggcc                                                                    64


<210> 46
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
aacatgagga tcacccatgt cctaaaccat cctgcggcct caacatgagg atcacccatg       60

tc                                                                      62


<210> 47
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
ggccctgaaa aagggcctgt tctaaaccat cctgcggcct ctactctggc cctgaaaaag       60

ggcc                                                                    64


<210> 48
<211> 317
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Leu Pro Pro Leu Glu Arg Leu Thr Leu Gly Ser Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys Gly Ser Gly Ser Gly Ser Met Ala Ser Asn Phe Thr 
            20                  25                  30          


Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr Val Ala 
        35                  40                  45              


Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu Trp Ile Ser Ser Asn Ser 
    50                  55                  60                  


Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser Ser Ala 
65                  70                  75                  80  


Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Gly Ala Trp 
                85                  90                  95      


Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala Thr Asn 
            100                 105                 110         


Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu Lys Asp 
        115                 120                 125             


Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile Tyr Gly 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser Pro Ala Gly Gly Gly Ala 
145                 150                 155                 160 


Pro Gly Ser Gly Gly Gly Ser Gln Leu His Leu Pro Gln Val Leu Ala 
                165                 170                 175     


Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly Asp Leu Thr Asp 
            180                 185                 190         


Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu Ala Gly Val Val 
        195                 200                 205             


Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val Ile Ser Val Ser 
    210                 215                 220                 


Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser Asp Arg Gly Leu 
225                 230                 235                 240 


Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Ser Leu Leu 
                245                 250                 255     


Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn Asn Lys Asp Asp 
            260                 265                 270         


Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly Gly Phe Arg Leu 
        275                 280                 285             


Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr Ser Pro Cys Gly 
    290                 295                 300                 


Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu Glu 
305                 310                 315         


<210> 49
<211> 412
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Glu Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu 
1               5                   10                  15      


Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val Arg Ser Asn 
            20                  25                  30          


Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu 
        35                  40                  45              


Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile 
    50                  55                  60                  


Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser 
65                  70                  75                  80  


Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met 
                85                  90                  95      


Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu 
            100                 105                 110         


Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro 
        115                 120                 125             


Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala 
    130                 135                 140                 


Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala 
145                 150                 155                 160 


Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His 
                165                 170                 175     


Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn 
            180                 185                 190         


Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys 
        195                 200                 205             


Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val 
    210                 215                 220                 


Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro Gly Gly Ser 
225                 230                 235                 240 


Gly Ser Gly Ala Gly Ser Gly Ser Pro Ala Gly Gly Gly Ala Pro Gly 
                245                 250                 255     


Ser Gly Gly Gly Ser Asn Ala Arg Thr Arg Arg Arg Glu Arg Arg Ala 
            260                 265                 270         


Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ala Arg Thr Arg Arg Arg 
    290                 295                 300                 


Glu Arg Arg Ala Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ala Arg 
                325                 330                 335     


Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala Gln Trp Lys Ala 
            340                 345                 350         


Ala Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Asn Ala Arg Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
    370                 375                 380                 


Gln Trp Lys Ala Ala Asn Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr 
385                 390                 395                 400 


Ala Gly Ser Leu Pro Pro Leu Glu Arg Leu Thr Leu 
                405                 410         


<210> 50
<211> 320
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Leu Pro Pro Leu Glu Arg Leu Thr Leu Gly Ser Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys Gly Ser Gly Ser Gly Ser Met Ala Ser Asn Phe Thr 
            20                  25                  30          


Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr Val Ala 
        35                  40                  45              


Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu Trp Ile Ser Ser Asn Ser 
    50                  55                  60                  


Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser Ser Ala 
65                  70                  75                  80  


Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Gly Ala Trp 
                85                  90                  95      


Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala Thr Asn 
            100                 105                 110         


Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu Lys Asp 
        115                 120                 125             


Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile Tyr Gly 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser Pro Ala Gly Gly Gly Ala 
145                 150                 155                 160 


Pro Gly Ser Gly Gly Gly Ser Gln Leu His Leu Pro Gln Val Leu Ala 
                165                 170                 175     


Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly Asp Leu Thr Asp 
            180                 185                 190         


Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu Ala Gly Val Val 
        195                 200                 205             


Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val Ile Ser Val Ser 
    210                 215                 220                 


Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser Asp Arg Gly Leu 
225                 230                 235                 240 


Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Ser Leu Leu 
                245                 250                 255     


Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn Asn Lys Asp Asp 
            260                 265                 270         


Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly Gly Phe Arg Leu 
        275                 280                 285             


Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr Ser Pro Cys Gly 
    290                 295                 300                 


Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu Glu Glu Pro Ala 
305                 310                 315                 320 


<210> 51
<211> 409
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys 
1               5                   10                  15      


Ile Glu Ser Gly Glu Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile 
            20                  25                  30          


Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser 
        35                  40                  45              


Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser 
    50                  55                  60                  


Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu 
65                  70                  75                  80  


Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg 
                85                  90                  95      


Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro 
            100                 105                 110         


Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala 
        115                 120                 125             


Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val 
    130                 135                 140                 


Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu 
145                 150                 155                 160 


Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His Gly Lys Val 
                165                 170                 175     


Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His 
            180                 185                 190         


Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu 
        195                 200                 205             


Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro 
    210                 215                 220                 


Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro Gly Gly Ser Gly Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Gly Ser Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Asn Ala Arg Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln 
            260                 265                 270         


Ala Gln Trp Lys Ala Ala Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Asn Ala Arg Thr Arg Arg Arg Glu Arg Arg 
    290                 295                 300                 


Ala Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ala Arg Thr Arg Arg 
                325                 330                 335     


Arg Glu Arg Arg Ala Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ala 
        355                 360                 365             


Arg Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala Gln Trp Lys 
    370                 375                 380                 


Ala Ala Asn Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser 
385                 390                 395                 400 


Leu Pro Pro Leu Glu Arg Leu Thr Leu 
                405                 


<210> 52
<211> 317
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Leu Pro Pro Leu Glu Arg Leu Thr Leu Gly Ser Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys Gly Ser Gly Ser Gly Ser Met Ala Ser Asn Phe Thr 
            20                  25                  30          


Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr Val Ala 
        35                  40                  45              


Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu Trp Ile Ser Ser Asn Ser 
    50                  55                  60                  


Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser Ser Ala 
65                  70                  75                  80  


Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Gly Ala Trp 
                85                  90                  95      


Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala Thr Asn 
            100                 105                 110         


Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu Lys Asp 
        115                 120                 125             


Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile Tyr Gly 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser Pro Ala Gly Gly Gly Ala 
145                 150                 155                 160 


Pro Gly Ser Gly Gly Gly Ser Gln Leu His Leu Pro Gln Val Leu Ala 
                165                 170                 175     


Asp Ala Val Ser Arg Leu Val Ile Gly Lys Phe Gly Asp Leu Thr Asp 
            180                 185                 190         


Asn Phe Ser Ser Pro His Ala Arg Arg Ile Gly Leu Ala Gly Val Val 
        195                 200                 205             


Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val Ile Cys Val Ser 
    210                 215                 220                 


Thr Gly Ser Lys Cys Ile Asn Gly Glu Tyr Leu Ser Asp Arg Gly Leu 
225                 230                 235                 240 


Ala Leu Asn Asp Cys His Ala Glu Ile Val Ser Arg Arg Ser Leu Leu 
                245                 250                 255     


Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn Asn Glu Asp Asp 
            260                 265                 270         


Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly Gly Phe Arg Leu 
        275                 280                 285             


Lys Glu Asn Ile Gln Phe His Leu Tyr Ile Ser Thr Ser Pro Cys Gly 
    290                 295                 300                 


Asp Ala Arg Ile Phe Ser Pro His Glu Ala Ile Leu Glu 
305                 310                 315         


<210> 53
<211> 412
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Glu Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu 
1               5                   10                  15      


Arg Thr Lys Ile Glu Ala Gly Gln Gly Thr Ile Pro Val Arg Asn Asn 
            20                  25                  30          


Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu 
        35                  40                  45              


Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile 
    50                  55                  60                  


Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser 
65                  70                  75                  80  


Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met 
                85                  90                  95      


Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu 
            100                 105                 110         


Asn Lys Pro Leu Leu Thr Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro 
        115                 120                 125             


Gly Lys Ala Pro Ile Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala 
    130                 135                 140                 


Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Gly Glu Leu Gly Arg Ala 
145                 150                 155                 160 


Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His 
                165                 170                 175     


Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn 
            180                 185                 190         


Val Tyr His Glu Thr Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys 
        195                 200                 205             


Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val 
    210                 215                 220                 


Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro Gly Gly Ser 
225                 230                 235                 240 


Gly Ser Gly Ala Gly Ser Gly Ser Pro Ala Gly Gly Gly Ala Pro Gly 
                245                 250                 255     


Ser Gly Gly Gly Ser Asn Ala Arg Thr Arg Arg Arg Glu Arg Arg Ala 
            260                 265                 270         


Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ala Arg Thr Arg Arg Arg 
    290                 295                 300                 


Glu Arg Arg Ala Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ala Arg 
                325                 330                 335     


Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala Gln Trp Lys Ala 
            340                 345                 350         


Ala Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Asn Ala Arg Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
    370                 375                 380                 


Gln Trp Lys Ala Ala Asn Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr 
385                 390                 395                 400 


Ala Gly Ser Leu Pro Pro Leu Glu Arg Leu Thr Leu 
                405                 410         


<210> 54
<211> 320
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Met Leu Pro Pro Leu Glu Arg Leu Thr Leu Gly Ser Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys Gly Ser Gly Ser Gly Ser Met Ala Ser Asn Phe Thr 
            20                  25                  30          


Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr Val Ala 
        35                  40                  45              


Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu Trp Ile Ser Ser Asn Ser 
    50                  55                  60                  


Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser Ser Ala 
65                  70                  75                  80  


Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Gly Ala Trp 
                85                  90                  95      


Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala Thr Asn 
            100                 105                 110         


Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu Lys Asp 
        115                 120                 125             


Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile Tyr Gly 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser Pro Ala Gly Gly Gly Ala 
145                 150                 155                 160 


Pro Gly Ser Gly Gly Gly Ser Gln Leu His Leu Pro Gln Val Leu Ala 
                165                 170                 175     


Asp Ala Val Ser Arg Leu Val Ile Gly Lys Phe Gly Asp Leu Thr Asp 
            180                 185                 190         


Asn Phe Ser Ser Pro His Ala Arg Arg Ile Gly Leu Ala Gly Val Val 
        195                 200                 205             


Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val Ile Cys Val Ser 
    210                 215                 220                 


Thr Gly Ser Lys Cys Ile Asn Gly Glu Tyr Leu Ser Asp Arg Gly Leu 
225                 230                 235                 240 


Ala Leu Asn Asp Cys His Ala Glu Ile Val Ser Arg Arg Ser Leu Leu 
                245                 250                 255     


Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn Asn Glu Asp Asp 
            260                 265                 270         


Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly Gly Phe Arg Leu 
        275                 280                 285             


Lys Glu Asn Ile Gln Phe His Leu Tyr Ile Ser Thr Ser Pro Cys Gly 
    290                 295                 300                 


Asp Ala Arg Ile Phe Ser Pro His Glu Ala Ile Leu Glu Glu Pro Ala 
305                 310                 315                 320 


<210> 55
<211> 409
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Met Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys 
1               5                   10                  15      


Ile Glu Ala Gly Gln Gly Thr Ile Pro Val Arg Asn Asn Ala Ser Ile 
            20                  25                  30          


Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser 
        35                  40                  45              


Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser 
    50                  55                  60                  


Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu 
65                  70                  75                  80  


Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg 
                85                  90                  95      


Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro 
            100                 105                 110         


Leu Leu Thr Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala 
        115                 120                 125             


Pro Ile Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val 
    130                 135                 140                 


Ile Asn Ala Thr Thr Gly Lys Gly Glu Leu Gly Arg Ala Ser Arg Leu 
145                 150                 155                 160 


Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His Gly Lys Val 
                165                 170                 175     


Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His 
            180                 185                 190         


Glu Thr Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu 
        195                 200                 205             


Phe Thr Ala Phe Ile Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro 
    210                 215                 220                 


Thr Glu Gln Asp Gln Phe Ser Leu Thr Pro Gly Gly Ser Gly Ser Gly 
225                 230                 235                 240 


Ala Gly Ser Gly Ser Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Asn Ala Arg Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln 
            260                 265                 270         


Ala Gln Trp Lys Ala Ala Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Asn Ala Arg Thr Arg Arg Arg Glu Arg Arg 
    290                 295                 300                 


Ala Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ala Arg Thr Arg Arg 
                325                 330                 335     


Arg Glu Arg Arg Ala Glu Lys Gln Ala Gln Trp Lys Ala Ala Asn Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ala 
        355                 360                 365             


Arg Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala Gln Trp Lys 
    370                 375                 380                 


Ala Ala Asn Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser 
385                 390                 395                 400 


Leu Pro Pro Leu Glu Arg Leu Thr Leu 
                405                 


<210> 56
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
auugcacucc g                                                            11


<210> 57
<211> 393
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Ser Gly Ser 
    130                 135                 140                 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met Thr Ser 
145                 150                 155                 160 


Glu Lys Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg Arg Ile Glu 
                165                 170                 175     


Pro Trp Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu Arg Lys Glu 
            180                 185                 190         


Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg Lys Ile Trp 
        195                 200                 205             


Arg Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val Asn Phe Ile 
    210                 215                 220                 


Lys Lys Phe Thr Ser Glu Arg Asp Phe His Pro Ser Met Ser Cys Ser 
225                 230                 235                 240 


Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys Ser Gln Ala 
                245                 250                 255     


Ile Arg Glu Phe Leu Ser Arg His Pro Gly Val Thr Leu Val Ile Tyr 
            260                 265                 270         


Val Ala Arg Leu Phe Trp His Met Asp Gln Gln Asn Arg Gln Gly Leu 
        275                 280                 285             


Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met Arg Ala Ser 
    290                 295                 300                 


Glu Tyr Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro Pro Gly Asp 
305                 310                 315                 320 


Glu Ala His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met Leu Tyr Ala 
                325                 330                 335     


Leu Glu Leu His Cys Ile Ile Leu Ser Leu Pro Pro Cys Leu Lys Ile 
            340                 345                 350         


Ser Arg Arg Trp Gln Asn His Leu Thr Phe Phe Arg Leu His Leu Gln 
        355                 360                 365             


Asn Cys His Tyr Gln Thr Ile Pro Pro His Ile Leu Leu Ala Thr Gly 
    370                 375                 380                 


Leu Ile His Pro Ser Val Ala Trp Arg 
385                 390             


<210> 58
<211> 365
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Ala Gln 
    130                 135                 140                 


Lys Glu Glu Ala Ala Val Ala Thr Glu Ala Ala Ser Gln Asn Gly Glu 
145                 150                 155                 160 


Asp Leu Glu Asn Leu Asp Asp Pro Glu Lys Leu Lys Glu Leu Ile Glu 
                165                 170                 175     


Leu Pro Pro Phe Glu Ile Val Thr Gly Glu Arg Leu Pro Ala Asn Phe 
            180                 185                 190         


Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly Arg Asn Lys 
        195                 200                 205             


Thr Phe Leu Cys Tyr Val Val Glu Ala Gln Gly Lys Gly Gly Gln Val 
    210                 215                 220                 


Gln Ala Ser Arg Gly Tyr Leu Glu Asp Glu His Ala Ala Ala His Ala 
225                 230                 235                 240 


Glu Glu Ala Phe Phe Asn Thr Ile Leu Pro Ala Phe Asp Pro Ala Leu 
                245                 250                 255     


Arg Tyr Asn Val Thr Trp Tyr Val Ser Ser Ser Pro Cys Ala Ala Cys 
            260                 265                 270         


Ala Asp Arg Ile Ile Lys Thr Leu Ser Lys Thr Lys Asn Leu Arg Leu 
        275                 280                 285             


Leu Ile Leu Val Gly Arg Leu Phe Met Trp Glu Glu Pro Glu Ile Gln 
    290                 295                 300                 


Ala Ala Leu Lys Lys Leu Lys Glu Ala Gly Cys Lys Leu Arg Ile Met 
305                 310                 315                 320 


Lys Pro Gln Asp Phe Glu Tyr Val Trp Gln Asn Phe Val Glu Gln Glu 
                325                 330                 335     


Glu Gly Glu Ser Lys Ala Phe Gln Pro Trp Glu Asp Ile Gln Glu Asn 
            340                 345                 350         


Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
        355                 360                 365 


<210> 59
<211> 340
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Trp 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Glu Ala 
    130                 135                 140                 


Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His Ile Phe Thr 
145                 150                 155                 160 


Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr 
                165                 170                 175     


Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln His 
            180                 185                 190         


Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr 
        195                 200                 205             


Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln 
    210                 215                 220                 


Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser 
225                 230                 235                 240 


Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln 
                245                 250                 255     


Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp 
            260                 265                 270         


Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly 
        275                 280                 285             


Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp 
    290                 295                 300                 


Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu 
305                 310                 315                 320 


Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln 
                325                 330                 335     


Asn Gln Gly Asn 
            340 


<210> 60
<211> 523
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Asn Pro 
    130                 135                 140                 


Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr Phe Tyr Asp 
145                 150                 155                 160 


Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr Thr Trp Leu 
                165                 170                 175     


Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu Leu Trp Asp 
            180                 185                 190         


Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Lys Pro Gln Tyr His Ala 
        195                 200                 205             


Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro Ala Tyr 
    210                 215                 220                 


Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys Pro Asp 
225                 230                 235                 240 


Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro Asn Val Thr 
                245                 250                 255     


Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg Asp Tyr 
            260                 265                 270         


Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val Thr Ile 
        275                 280                 285             


Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val Tyr Asn 
    290                 295                 300                 


Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu Asn Tyr Ala 
305                 310                 315                 320 


Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu Met Asp Pro 
                325                 330                 335     


Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val Leu Arg Arg 
            340                 345                 350         


Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr 
        355                 360                 365             


Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn Glu Ala Lys 
    370                 375                 380                 


Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu 
385                 390                 395                 400 


Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val 
                405                 410                 415     


Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly 
            420                 425                 430         


Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile 
        435                 440                 445             


Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu 
    450                 455                 460                 


Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp 
465                 470                 475                 480 


Glu Phe Glu Tyr Cys Trp Phe Thr Phe Val Tyr Arg Gln Gly Cys Pro 
                485                 490                 495     


Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala Leu Ser Gly 
            500                 505                 510         


Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
        515                 520             


<210> 61
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Asn Pro 
    130                 135                 140                 


Gln Ile Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr Phe Tyr Phe 
145                 150                 155                 160 


Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu Thr Trp Leu 
                165                 170                 175     


Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val Ser Trp Lys 
            180                 185                 190         


Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His Cys His Ala 
        195                 200                 205             


Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu Ser Pro Asn 
    210                 215                 220                 


Thr Lys Tyr Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro Cys Pro Asp 
225                 230                 235                 240 


Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser Asn Val Asn 
                245                 250                 255     


Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Tyr Pro Cys Tyr 
            260                 265                 270         


Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Val Ala Val Glu Ile 
        275                 280                 285             


Met Asp Tyr Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn 
    290                 295                 300                 


Asp Asn Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Thr Asn Phe Arg 
305                 310                 315                 320 


Leu Leu Lys Arg Arg Leu Arg Glu Ser Leu Gln 
                325                 330     


<210> 62
<211> 527
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Asn Pro 
    130                 135                 140                 


Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr Phe Tyr Asp 
145                 150                 155                 160 


Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr Thr Trp Leu 
                165                 170                 175     


Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu Leu Trp Asp 
            180                 185                 190         


Thr Gly Val Phe Arg Gly Pro Val Leu Pro Lys Arg Gln Ser Asn His 
        195                 200                 205             


Arg Gln Glu Val Tyr Phe Arg Phe Glu Asn His Ala Glu Met Cys Phe 
    210                 215                 220                 


Leu Ser Trp Phe Cys Gly Asn Arg Leu Pro Ala Asn Arg Arg Phe Gln 
225                 230                 235                 240 


Ile Thr Trp Phe Val Ser Trp Asn Pro Cys Leu Pro Cys Val Val Lys 
                245                 250                 255     


Val Thr Lys Phe Leu Ala Glu His Pro Asn Val Thr Leu Thr Ile Ser 
            260                 265                 270         


Ala Ala Arg Leu Tyr Tyr Tyr Arg Asp Arg Asp Trp Arg Trp Val Leu 
        275                 280                 285             


Leu Arg Leu His Lys Ala Gly Ala Arg Val Lys Ile Met Asp Tyr Glu 
    290                 295                 300                 


Asp Phe Ala Tyr Cys Trp Glu Asn Phe Val Cys Asn Glu Gly Gln Pro 
305                 310                 315                 320 


Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn Tyr Ala Ser Leu His Arg 
                325                 330                 335     


Thr Leu Lys Glu Ile Leu Arg Asn Pro Met Glu Ala Met Tyr Pro His 
            340                 345                 350         


Ile Phe Tyr Phe His Phe Lys Asn Leu Leu Lys Ala Cys Gly Arg Asn 
        355                 360                 365             


Glu Ser Trp Leu Cys Phe Thr Met Glu Val Thr Lys His His Ser Ala 
    370                 375                 380                 


Val Phe Arg Lys Arg Gly Val Phe Arg Asn Gln Val Asp Pro Glu Thr 
385                 390                 395                 400 


His Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile 
                405                 410                 415     


Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr Trp Tyr Thr Ser Trp Ser 
            420                 425                 430         


Pro Cys Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His 
        435                 440                 445             


Ser Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Cys Tyr Phe Trp 
    450                 455                 460                 


Asp Thr Asp Tyr Gln Glu Gly Leu Cys Ser Leu Ser Gln Glu Gly Ala 
465                 470                 475                 480 


Ser Val Lys Ile Met Gly Tyr Lys Asp Phe Val Ser Cys Trp Lys Asn 
                485                 490                 495     


Phe Val Tyr Ser Asp Asp Glu Pro Phe Lys Pro Trp Lys Gly Leu Gln 
            500                 505                 510         


Thr Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ile Leu Gln 
        515                 520                 525         


<210> 63
<211> 514
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Lys Pro 
    130                 135                 140                 


His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr Phe Ser Tyr 
145                 150                 155                 160 


Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr Val Trp Leu 
                165                 170                 175     


Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg Leu Asp Ala 
            180                 185                 190         


Lys Ile Phe Arg Gly Gln Val Tyr Ser Gln Pro Glu His His Ala Glu 
        195                 200                 205             


Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro Ala Tyr Lys 
    210                 215                 220                 


Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys Pro Asp Cys 
225                 230                 235                 240 


Val Ala Lys Leu Ala Glu Phe Leu Ala Glu His Pro Asn Val Thr Leu 
                245                 250                 255     


Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg Asp Tyr Arg 
            260                 265                 270         


Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val Lys Ile Met 
        275                 280                 285             


Asp Asp Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val Tyr Ser Glu 
    290                 295                 300                 


Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn Tyr Ala Phe 
305                 310                 315                 320 


Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met Glu Ala Met 
                325                 330                 335     


Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Arg Lys Ala Tyr 
            340                 345                 350         


Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val Val Lys His 
        355                 360                 365             


His Ser Pro Val Ser Trp Lys Arg Gly Val Phe Arg Asn Gln Val Asp 
    370                 375                 380                 


Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys 
385                 390                 395                 400 


Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr Trp Tyr Thr 
                405                 410                 415     


Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu 
            420                 425                 430         


Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr 
        435                 440                 445             


Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln 
    450                 455                 460                 


Glu Gly Ala Ser Val Glu Ile Met Gly Tyr Lys Asp Phe Lys Tyr Cys 
465                 470                 475                 480 


Trp Glu Asn Phe Val Tyr Asn Asp Asp Glu Pro Phe Lys Pro Trp Lys 
                485                 490                 495     


Gly Leu Lys Tyr Asn Phe Leu Phe Leu Asp Ser Lys Leu Gln Glu Ile 
            500                 505                 510         


Leu Glu 
        


<210> 64
<211> 525
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Lys Pro 
    130                 135                 140                 


His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr Phe Ser Tyr 
145                 150                 155                 160 


Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr Val Trp Leu 
                165                 170                 175     


Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro Leu Asp Ala 
            180                 185                 190         


Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr His Pro Glu 
        195                 200                 205             


Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu His Arg Asp 
    210                 215                 220                 


Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro Cys Thr Lys 
225                 230                 235                 240 


Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro Lys Val Thr 
                245                 250                 255     


Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp Pro Asp Tyr 
            260                 265                 270         


Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly Pro Arg Ala 
        275                 280                 285             


Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys Trp Ser Lys 
    290                 295                 300                 


Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn Asn Leu Pro 
305                 310                 315                 320 


Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile Leu Arg His 
                325                 330                 335     


Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp 
            340                 345                 350         


Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met 
        355                 360                 365             


His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys 
    370                 375                 380                 


Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu 
385                 390                 395                 400 


Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln 
                405                 410                 415     


Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys 
            420                 425                 430         


Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu 
        435                 440                 445             


Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys Gln Glu 
    450                 455                 460                 


Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Ile Met Thr 
465                 470                 475                 480 


Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly 
                485                 490                 495     


Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu 
            500                 505                 510         


Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
        515                 520                 525 


<210> 65
<211> 341
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Ala Leu 
    130                 135                 140                 


Leu Thr Ala Glu Thr Phe Arg Leu Gln Phe Asn Asn Lys Arg Arg Leu 
145                 150                 155                 160 


Arg Arg Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr Gln Leu Thr 
                165                 170                 175     


Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly Tyr Phe Glu Asn Lys Lys 
            180                 185                 190         


Lys Cys His Ala Glu Ile Cys Phe Ile Asn Glu Ile Lys Ser Met Gly 
        195                 200                 205             


Leu Asp Glu Thr Gln Cys Tyr Gln Val Thr Cys Tyr Leu Thr Trp Ser 
    210                 215                 220                 


Pro Cys Ser Ser Cys Ala Trp Glu Leu Val Asp Phe Ile Lys Ala His 
225                 230                 235                 240 


Asp His Leu Asn Leu Gly Ile Phe Ala Ser Arg Leu Tyr Tyr His Trp 
                245                 250                 255     


Cys Lys Pro Gln Gln Lys Gly Leu Arg Leu Leu Cys Gly Ser Gln Val 
            260                 265                 270         


Pro Val Glu Val Met Gly Phe Pro Glu Phe Ala Asp Cys Trp Glu Asn 
        275                 280                 285             


Phe Val Asp His Glu Lys Pro Leu Ser Phe Asn Pro Tyr Lys Met Leu 
    290                 295                 300                 


Glu Glu Leu Asp Lys Asn Ser Arg Ala Ile Lys Arg Arg Leu Glu Arg 
305                 310                 315                 320 


Ile Lys Ile Pro Gly Val Arg Ala Gln Gly Arg Tyr Met Asp Ile Leu 
                325                 330                 335     


Cys Asp Ala Glu Val 
            340     


<210> 66
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Glu Pro 
    130                 135                 140                 


Ile Tyr Glu Glu Tyr Leu Ala Asn His Gly Thr Ile Val Lys Pro Tyr 
145                 150                 155                 160 


Tyr Trp Leu Ser Phe Ser Leu Asp Cys Ser Asn Cys Pro Tyr His Ile 
                165                 170                 175     


Arg Thr Gly Glu Glu Ala Arg Val Ser Leu Thr Glu Phe Cys Gln Ile 
            180                 185                 190         


Phe Gly Phe Pro Tyr Gly Thr Thr Phe Pro Gln Thr Lys His Leu Thr 
        195                 200                 205             


Phe Tyr Glu Leu Lys Thr Ser Ser Gly Ser Leu Val Gln Lys Gly His 
    210                 215                 220                 


Ala Ser Ser Cys Thr Gly Asn Tyr Ile His Pro Glu Ser Met Leu Phe 
225                 230                 235                 240 


Glu Met Asn Gly Tyr Leu Asp Ser Ala Ile Tyr Asn Asn Asp Ser Ile 
                245                 250                 255     


Arg His Ile Ile Leu Tyr Ser Asn Asn Ser Pro Cys Asn Glu Ala Asn 
            260                 265                 270         


His Cys Cys Ile Ser Lys Met Tyr Asn Phe Leu Ile Thr Tyr Pro Gly 
        275                 280                 285             


Ile Thr Leu Ser Ile Tyr Phe Ser Gln Leu Tyr His Thr Glu Met Asp 
    290                 295                 300                 


Phe Pro Ala Ser Ala Trp Asn Arg Glu Ala Leu Arg Ser Leu Ala Ser 
305                 310                 315                 320 


Leu Trp Pro Arg Val Val Leu Ser Pro Ile Ser Gly Gly Ile Trp His 
                325                 330                 335     


Ser Val Leu His Ser Phe Ile Ser Gly Val Ser Gly Ser His Val Phe 
            340                 345                 350         


Gln Pro Ile Leu Thr Gly Arg Ala Leu Ala Asp Arg His Asn Ala Tyr 
        355                 360                 365             


Glu Ile Asn Ala Ile Thr Gly Val Lys Pro Tyr Phe Thr Asp Val Leu 
    370                 375                 380                 


Leu Gln Thr Lys Arg Asn Pro Asn Thr Lys Ala Gln Glu Ala Leu Glu 
385                 390                 395                 400 


Ser Tyr Pro Leu Asn Asn Ala Phe Pro Gly Gln Phe Phe Gln Met Pro 
                405                 410                 415     


Ser Gly Gln Leu Gln Pro Asn Leu Pro Pro Asp Leu Arg Ala Pro Val 
            420                 425                 430         


Val Phe Val Leu Val Pro Leu Arg Asp Leu Pro Pro Met His Met Gly 
        435                 440                 445             


Gln Asn Pro Asn Lys Pro Arg Asn Ile Val Arg His Leu Asn Met Pro 
    450                 455                 460                 


Gln Met Ser Phe Gln Glu Thr Lys Asp Leu Gly Arg Leu Pro Thr Gly 
465                 470                 475                 480 


Arg Ser Val Glu Ile Val Glu Ile Thr Glu Gln Phe Ala Ser Ser Lys 
                485                 490                 495     


Glu Ala Asp Glu Lys Lys Lys Lys Lys Gly Lys Lys 
            500                 505             


<210> 67
<211> 339
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Asp Ser 
    130                 135                 140                 


Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys Asn Val Arg 
145                 150                 155                 160 


Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val Val Lys Arg 
                165                 170                 175     


Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr Leu Arg Asn 
            180                 185                 190         


Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr Ile Ser Asp 
        195                 200                 205             


Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp Phe Thr Ser 
    210                 215                 220                 


Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp Phe Leu Arg 
225                 230                 235                 240 


Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg Leu Tyr Phe 
                245                 250                 255     


Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg Leu His Arg 
            260                 265                 270         


Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr Phe Tyr Cys 
        275                 280                 285             


Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys Ala Trp Glu 
    290                 295                 300                 


Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu Arg Arg Ile 
305                 310                 315                 320 


Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala Phe Arg Thr 
                325                 330                 335     


Leu Gly Leu 
            


<210> 68
<211> 643
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile 
65                  70                  75                  80  


Pro Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met 
                85                  90                  95      


Gln Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala 
            100                 105                 110         


Asn Ser Gly Ile Tyr Gly Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser 
        115                 120                 125             


Pro Ala Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser Met Trp Thr 
    130                 135                 140                 


Ala Asp Glu Ile Ala Gln Leu Cys Tyr Glu His Tyr Gly Ile Arg Leu 
145                 150                 155                 160 


Pro Lys Lys Gly Lys Pro Glu Pro Asn His Glu Trp Thr Leu Leu Ala 
                165                 170                 175     


Ala Val Val Lys Ile Gln Ser Pro Ala Asp Lys Ala Cys Asp Thr Pro 
            180                 185                 190         


Asp Lys Pro Val Gln Val Thr Lys Glu Val Val Ser Met Gly Thr Gly 
        195                 200                 205             


Thr Lys Cys Ile Gly Gln Ser Lys Met Arg Lys Asn Gly Asp Ile Leu 
    210                 215                 220                 


Asn Asp Ser His Ala Glu Val Ile Ala Arg Arg Ser Phe Gln Arg Tyr 
225                 230                 235                 240 


Leu Leu His Gln Leu Gln Leu Ala Ala Thr Leu Lys Glu Asp Ser Ile 
                245                 250                 255     


Phe Val Pro Gly Thr Gln Lys Gly Val Trp Lys Leu Arg Arg Asp Leu 
            260                 265                 270         


Ile Phe Val Phe Phe Ser Ser His Thr Pro Cys Gly Asp Ala Ser Ile 
        275                 280                 285             


Ile Pro Met Leu Glu Phe Glu Asp Gln Pro Cys Cys Pro Val Phe Arg 
    290                 295                 300                 


Asn Trp Ala His Asn Ser Ser Val Glu Ala Ser Ser Asn Leu Glu Ala 
305                 310                 315                 320 


Pro Gly Asn Glu Arg Lys Cys Glu Asp Pro Asp Ser Pro Val Thr Lys 
                325                 330                 335     


Lys Met Arg Leu Glu Pro Gly Thr Ala Ala Arg Glu Val Thr Asn Gly 
            340                 345                 350         


Ala Ala His His Gln Ser Phe Gly Lys Gln Lys Ser Gly Pro Ile Ser 
        355                 360                 365             


Pro Gly Ile His Ser Cys Asp Leu Thr Val Glu Gly Leu Ala Thr Val 
    370                 375                 380                 


Thr Arg Ile Ala Pro Gly Ser Ala Lys Val Ile Asp Val Tyr Arg Thr 
385                 390                 395                 400 


Gly Ala Lys Cys Val Pro Gly Glu Ala Gly Asp Ser Gly Lys Pro Gly 
                405                 410                 415     


Ala Ala Phe His Gln Val Gly Leu Leu Arg Val Lys Pro Gly Arg Gly 
            420                 425                 430         


Asp Arg Thr Arg Ser Met Ser Cys Ser Asp Lys Met Ala Arg Trp Asn 
        435                 440                 445             


Val Leu Gly Cys Gln Gly Ala Leu Leu Met His Leu Leu Glu Glu Pro 
    450                 455                 460                 


Ile Tyr Leu Ser Ala Val Val Ile Gly Lys Cys Pro Tyr Ser Gln Glu 
465                 470                 475                 480 


Ala Met Gln Arg Ala Leu Ile Gly Arg Cys Gln Asn Val Ser Ala Leu 
                485                 490                 495     


Pro Lys Gly Phe Gly Val Gln Glu Leu Lys Ile Leu Gln Ser Asp Leu 
            500                 505                 510         


Leu Phe Glu Gln Ser Arg Ser Ala Val Gln Ala Lys Arg Ala Asp Ser 
        515                 520                 525             


Pro Gly Arg Leu Val Pro Cys Gly Ala Ala Ile Ser Trp Ser Ala Val 
    530                 535                 540                 


Pro Glu Gln Pro Leu Asp Val Thr Ala Asn Gly Phe Pro Gln Gly Thr 
545                 550                 555                 560 


Thr Lys Lys Thr Ile Gly Ser Leu Gln Ala Arg Ser Gln Ile Ser Lys 
                565                 570                 575     


Val Glu Leu Phe Arg Ser Phe Gln Lys Leu Leu Ser Arg Ile Ala Arg 
            580                 585                 590         


Asp Lys Trp Pro His Ser Leu Arg Val Gln Lys Leu Asp Thr Tyr Gln 
        595                 600                 605             


Glu Tyr Lys Glu Ala Ala Ser Ser Tyr Gln Glu Ala Trp Ser Thr Leu 
    610                 615                 620                 


Arg Lys Gln Val Phe Gly Ser Trp Ile Arg Asn Pro Pro Asp Tyr His 
625                 630                 635                 640 


Gln Phe Lys 
            


<210> 69
<211> 741
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 69
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaatcat      600

tattcgagca ctcagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtac      720

tcagatctcg agctcaagta g                                                741


<210> 70
<211> 140
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 70
gcgcctccat cgaagtgtaa agccatctat cgatgggaaa gtctttgctc tccccggaca       60

ctctgctcct taaatgaaac acgggctcgt gcacggggcc aaagcgcctc catcgaagtg      120

taaagccatc tatcgatggg                                                  140


<210> 71
<211> 98
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
gccatctatc gatgggaaag tctttgctct ccccggacac tctgctcctt aaatgaaaca       60

cgggctcgtg cacggggcca aagccatcta tcgatggg                               98


<210> 72
<211> 68
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
gccatctatc gatgggaaac ggactgagtg ctcaaaatga ttgtcgggca aagccatcta       60

tcgatggg                                                                68


<210> 73
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
gccatctatc gatgggaaat gctcagggcg gactgagaaa attgtcgggc agcagcacga       60

aagccatcta tcgatggg                                                     78


<210> 74
<211> 102
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 74
aacatgagga tcacccatgt cgtctttgct ctccccggac actctgctcc ttaaatgaaa       60

cacgggctcg tgcacggggc caacatgagg atcacccatg tc                         102


<210> 75
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
aacatgagga tcacccatgt ccggactgag tgctcaaaat gattgtcggg caacatgagg       60

atcacccatg tc                                                           72


<210> 76
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
aacatgagga tcacccatgt ctgctcaggg cggactgaga aaattgtcgg gcagcagcac       60

gaacatgagg atcacccatg tc                                                82


<210> 77
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
gcgcctccat cgaagtgt                                                     18


<210> 78
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
gccatctatc gatggg                                                       16


<210> 79
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
caaaccgagc ggtgtc                                                       16


<210> 80
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
acaaaccgag cggtgt                                                       16


<210> 81
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
tacaaaccga gcggtg                                                       16


<210> 82
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
ttacaaaccg agcggt                                                       16


<210> 83
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 83
caaaccgagc ggtgtct                                                      17


<210> 84
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 84
acaaaccgag cggtgtc                                                      17


<210> 85
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
tacaaaccga gcggtgt                                                      17


<210> 86
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
ttacaaaccg agcggtg                                                      17


<210> 87
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
caaaccgagc ggtgtctg                                                     18


<210> 88
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
acaaaccgag cggtgtct                                                     18


<210> 89
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
tacaaaccga gcggtgtc                                                     18


<210> 90
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
ttacaaaccg agcggtgt                                                     18


<210> 91
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 91
caaaccgagc ggtgtctgt                                                    19


<210> 92
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 92
acaaaccgag cggtgtctg                                                    19


<210> 93
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 93
tacaaaccga gcggtgtct                                                    19


<210> 94
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 94
ttacaaaccg agcggtgtc                                                    19


<210> 95
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 95
caaaccgagc ggtgtctgtg                                                   20


<210> 96
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 96
acaaaccgag cggtgtctgt                                                   20


<210> 97
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 97
tacaaaccga gcggtgtctg                                                   20


<210> 98
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
ttacaaaccg agcggtgtct                                                   20


<210> 99
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 99
caaaccgagc ggtgtctgtg a                                                 21


<210> 100
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
acaaaccgag cggtgtctgt g                                                 21


<210> 101
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
tacaaaccga gcggtgtctg t                                                 21


<210> 102
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
ttacaaaccg agcggtgtct g                                                 21


<210> 103
<211> 66
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 103
cacttgggtg tgaatgaaag tctcacagac accgctcagt ttgtaaaact tttcttcctt       60

ccaaag                                                                  66


<210> 104
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
aacatgagga tcacccatgt ccaaaccgag cggtgtctgt gaacatgagg atcacccatg       60

tc                                                                      62


<210> 105
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
aacatgagga tcacccatgt ctacaaaccg agcggtgtct gaacatgagg atcacccatg       60

tc                                                                      62


<210> 106
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
aacatgagga tcacccatgt ctttacaaac cgagcggtgt caacatgagg atcacccatg       60

tc                                                                      62


<210> 107
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
aacatgagga tcacccatgt ccaaaccgag cggtgtctgt gagacaacat gaggatcacc       60

catgtc                                                                  66


<210> 108
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 108
aacatgagga tcacccatgt ccaaaccgag cggtgtcaac atgaggatca cccatgtc         58


<210> 109
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 109
aagaaaagtt aacatgagga tcacccatgt ccaaaccgag cggtgtctgt gaacatgagg       60

atcacccatg tcctttcatt ca                                                82


<210> 110
<211> 102
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 110
ctttggaagg aagaaaagtt aacatgagga tcacccatgt ccaaaccgag cggtgtctgt       60

gaacatgagg atcacccatg tcctttcatt cacacccaag tg                         102


<210> 111
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 111
ttgggaaatc cagctagcgg cagtattctg t                                      31


<210> 112
<211> 31
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 112
gggcgatgcc acctaaggca agctgaccct g                                      31


<210> 113
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 113
gccctaggtg gcatcgccc                                                    19


<210> 114
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 114
cagggtcagc ttgccctag                                                    19


<210> 115
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 115
gccccaggtg gcatcgccc                                                    19


<210> 116
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 116
agggtcagct tgccccagg                                                    19


<210> 117
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 117
agcaataaaa tggc                                                         14


<210> 118
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 118
agcaataaaa tggc                                                         14


<210> 119
<211> 34
<212> DNA
<213> Mus sp.

<400> 119
gagcaataaa atggcttcaa ctatctgagt gaca                                   34


<210> 120
<211> 34
<212> DNA
<213> Mus sp.

<400> 120
gagcaataaa atggcttcaa ctatctgagt gaca                                   34


<210> 121
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 121
gagccataaa atggcttcaa ctatctgagt gaca                                   34


<210> 122
<211> 34
<212> DNA
<213> Mus sp.

<400> 122
gagcaataaa atggcttcaa ctatctgagt gaca                                   34


<210> 123
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 123
gagcaatgga atggcttcaa ctatctgagt gaca                                   34


<210> 124
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 124
gagccataaa atggcttcaa ctatctgagt gaca                                   34


<210> 125
<211> 34
<212> DNA
<213> Mus sp.

<400> 125
gagcaataaa atggcttcaa ctatctgagt gaca                                   34


<210> 126
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 126
gagcaatgga atggcttcaa ctatctgagt gaca                                   34


<210> 127
<211> 34
<212> DNA
<213> Mus sp.

<400> 127
gagcaataaa atggcttcaa ctatctgagt gaca                                   34


<210> 128
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 128
gagcaatgga atggcttcaa ctatctgagt gaca                                   34


<210> 129
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 129
gagcaatgaa atggcttcaa ctatctgagt gaca                                   34


<210> 130
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 130
gagcagtgga atggcttcaa ctatctgagt gaca                                   34


<210> 131
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 131
ccgctcagtt tnt                                                          13


<210> 132
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (7)..(8)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (12)..(12)
<223> a, c, t, g, unknown or other

<400> 132
ccgctcnntt tnt                                                          13


<210> 133
<211> 28
<212> DNA
<213> Mus sp.

<400> 133
agacaccgct catgtcttat ctagcatg                                          28


<210> 134
<211> 28
<212> DNA
<213> Mus sp.

<400> 134
agacaccgct catgtcttat ctagcatg                                          28


<210> 135
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 135
agacaccgct cgtgtcttat ctagcatg                                          28


<210> 136
<211> 28
<212> DNA
<213> Mus sp.

<400> 136
agacaccgct catgtcttat ctagcatg                                          28


<210> 137
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 137
agacaccgct cgtgtcttat ctagcatg                                          28


<210> 138
<211> 28
<212> DNA
<213> Mus sp.

<400> 138
agacaccgct catgtcttat ctagcatg                                          28


<210> 139
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 139
agacaccgct cgtgtcttat ctagcatg                                          28


<210> 140
<211> 429
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      ADAR1 catalytic domain sequence

<400> 140
Lys Ala Glu Arg Met Gly Phe Thr Glu Val Thr Pro Val Thr Gly Ala 
1               5                   10                  15      


Ser Leu Arg Arg Thr Met Leu Leu Leu Ser Arg Ser Pro Glu Ala Gln 
            20                  25                  30          


Pro Lys Thr Leu Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala 
        35                  40                  45              


Met Leu Ser His Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro 
    50                  55                  60                  


Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp 
65                  70                  75                  80  


Ser Glu Asp Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys 
                85                  90                  95      


Val Lys Gly Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys 
            100                 105                 110         


His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser 
        115                 120                 125             


Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu 
    130                 135                 140                 


Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe 
145                 150                 155                 160 


His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp 
                165                 170                 175     


Lys Ser Cys Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr 
            180                 185                 190         


Pro Val Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg Thr Lys Val Glu 
        195                 200                 205             


Asn Gly Glu Gly Thr Ile Pro Val Glu Ser Ser Asp Ile Val Pro Thr 
    210                 215                 220                 


Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu Arg Thr Met Ser Cys Ser 
225                 230                 235                 240 


Asp Lys Ile Leu Arg Trp Asn Val Leu Gly Leu Gln Gly Ala Leu Leu 
                245                 250                 255     


Thr His Phe Leu Gln Pro Ile Tyr Leu Lys Ser Val Thr Leu Gly Tyr 
            260                 265                 270         


Leu Phe Ser Gln Gly His Leu Thr Arg Ala Ile Cys Cys Arg Val Thr 
        275                 280                 285             


Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu Arg His Pro Phe Ile Val 
    290                 295                 300                 


Asn His Pro Lys Val Gly Arg Val Ser Ile Tyr Asp Ser Lys Arg Gln 
305                 310                 315                 320 


Ser Gly Lys Thr Lys Glu Thr Ser Val Asn Trp Cys Leu Ala Asp Gly 
                325                 330                 335     


Tyr Asp Leu Glu Ile Leu Asp Gly Thr Arg Gly Thr Val Asp Gly Pro 
            340                 345                 350         


Arg Asn Glu Leu Ser Arg Val Ser Lys Lys Asn Ile Phe Leu Leu Phe 
        355                 360                 365             


Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg Asp Leu Leu Arg Leu Ser 
    370                 375                 380                 


Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp Tyr Glu Thr Ala Lys Asn 
385                 390                 395                 400 


Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly Tyr Gly Asn Trp Ile Ser 
                405                 410                 415     


Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu Cys Pro Val 
            420                 425                 


<210> 141
<211> 385
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      ADAR2 catalytic domain sequence

<400> 141
Gln Leu His Leu Pro Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val 
1               5                   10                  15      


Leu Gly Lys Phe Gly Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala 
            20                  25                  30          


Arg Arg Lys Val Leu Ala Gly Val Val Met Thr Thr Gly Thr Asp Val 
        35                  40                  45              


Lys Asp Ala Lys Val Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn 
    50                  55                  60                  


Gly Glu Tyr Met Ser Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala 
65                  70                  75                  80  


Glu Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu 
                85                  90                  95      


Glu Leu Tyr Leu Asn Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln 
            100                 105                 110         


Lys Ser Glu Arg Gly Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His 
        115                 120                 125             


Leu Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro 
    130                 135                 140                 


His Glu Pro Ile Leu Glu Glu Pro Ala Asp Arg His Pro Asn Arg Lys 
145                 150                 155                 160 


Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile 
                165                 170                 175     


Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln 
            180                 185                 190         


Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp 
        195                 200                 205             


Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro 
    210                 215                 220                 


Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His 
225                 230                 235                 240 


Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro 
                245                 250                 255     


Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala 
            260                 265                 270         


Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr 
        275                 280                 285             


Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp 
    290                 295                 300                 


Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg 
305                 310                 315                 320 


Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys 
                325                 330                 335     


Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu 
            340                 345                 350         


Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly 
        355                 360                 365             


Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu 
    370                 375                 380                 


Thr 
385 


<210> 142
<211> 298
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      ADAR dsRBD sequence

<400> 142
Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val 
1               5                   10                  15      


Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr 
            20                  25                  30          


Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys 
    50                  55                  60                  


Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys 
65                  70                  75                  80  


Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr 
                85                  90                  95      


Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser 
            100                 105                 110         


Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys 
        115                 120                 125             


Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln 
    130                 135                 140                 


Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser 
145                 150                 155                 160 


Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu 
                165                 170                 175     


Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val 
            180                 185                 190         


Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu 
        195                 200                 205             


Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val 
    210                 215                 220                 


Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu 
225                 230                 235                 240 


Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly 
                245                 250                 255     


Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln 
            260                 265                 270         


Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala 
        275                 280                 285             


Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn 
    290                 295             


<210> 143
<211> 564
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 143
Met Leu Arg Ser Phe Val Gln Phe Pro Asn Ala Ser Glu Ala His Leu 
1               5                   10                  15      


Ala Met Gly Arg Thr Leu Ser Val Asn Thr Asp Phe Thr Ser Asp Gln 
            20                  25                  30          


Ala Asp Phe Pro Asp Thr Leu Phe Asn Gly Phe Glu Thr Pro Asp Lys 
        35                  40                  45              


Ala Glu Pro Pro Phe Tyr Val Gly Ser Asn Gly Asp Asp Ser Phe Ser 
    50                  55                  60                  


Ser Ser Gly Asp Leu Ser Leu Ser Ala Ser Pro Val Pro Ala Ser Leu 
65                  70                  75                  80  


Ala Gln Pro Pro Leu Pro Val Leu Pro Pro Phe Pro Pro Pro Ser Gly 
                85                  90                  95      


Lys Asn Pro Val Met Ile Leu Asn Glu Leu Arg Pro Gly Leu Lys Tyr 
            100                 105                 110         


Asp Phe Leu Ser Glu Ser Gly Glu Ser His Ala Lys Ser Phe Val Met 
        115                 120                 125             


Ser Val Val Val Asp Gly Gln Phe Phe Glu Gly Ser Gly Arg Asn Lys 
    130                 135                 140                 


Lys Leu Ala Lys Ala Arg Ala Ala Gln Ser Ala Leu Ala Ala Ile Phe 
145                 150                 155                 160 


Asn Leu His Leu Asp Gln Thr Pro Ser Arg Gln Pro Ile Pro Ser Glu 
                165                 170                 175     


Gly Leu Gln Leu His Leu Pro Gln Val Leu Ala Asp Ala Val Ser Arg 
            180                 185                 190         


Leu Val Leu Gly Lys Phe Gly Asp Leu Thr Asp Asn Phe Ser Ser Pro 
        195                 200                 205             


His Ala Arg Arg Lys Val Leu Ala Gly Val Val Met Thr Thr Gly Thr 
    210                 215                 220                 


Asp Val Lys Asp Ala Lys Val Ile Ser Val Ser Thr Gly Thr Lys Cys 
225                 230                 235                 240 


Ile Asn Gly Glu Tyr Met Ser Asp Arg Gly Leu Ala Leu Asn Asp Cys 
                245                 250                 255     


His Ala Glu Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu Tyr Thr 
            260                 265                 270         


Gln Leu Glu Leu Tyr Leu Asn Asn Lys Asp Asp Gln Lys Arg Ser Ile 
        275                 280                 285             


Phe Gln Lys Ser Glu Arg Gly Gly Phe Arg Leu Lys Glu Asn Val Gln 
    290                 295                 300                 


Phe His Leu Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala Arg Ile Phe 
305                 310                 315                 320 


Ser Pro His Glu Pro Ile Leu Glu Glu Pro Ala Asp Arg His Pro Asn 
                325                 330                 335     


Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly 
            340                 345                 350         


Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly Val 
        355                 360                 365             


Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile Ala 
    370                 375                 380                 


Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe Val 
385                 390                 395                 400 


Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His Gly 
                405                 410                 415     


Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu Asp 
            420                 425                 430         


Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile Ser 
        435                 440                 445             


Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val Asn 
    450                 455                 460                 


Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr Gly 
465                 470                 475                 480 


Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu Tyr 
                485                 490                 495     


Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu Arg 
            500                 505                 510         


Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala Ala 
        515                 520                 525             


Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile Lys 
    530                 535                 540                 


Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln Phe 
545                 550                 555                 560 


Ser Leu Thr Pro 
                


<210> 144
<211> 36
<212> DNA
<213> Mus sp.

<400> 144
ctcacagaca ccgctcggtt tgtaaaactt ttcttc                                 36


<210> 145
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 145
ctcacagaca ccgctcagtt tgtaaaactt ttcttc                                 36


<210> 146
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 146
ctcacagaca ccgctcagtt tgtaaaactt ttcttc                                 36


<210> 147
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 147
ctcacagaca ccgctcatgt cttatctagc atgaca                                 36


<210> 148
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 148
ctcacagaca ccgctcgtgt cttatctagc atgaca                                 36


<210> 149
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 149
cggcctcagt gagcga                                                       16


<210> 150
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 150
ggaaccccta gtgatggagt t                                                 21


<210> 151
<211> 51
<212> DNA
<213> Homo sapiens

<400> 151
agcggcagta ttctgtacag tagacacaag aattatgtac gccttttatc a                51


<210> 152
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (46)..(51)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (53)..(66)
<223> a, c, t, g, unknown or other

<400> 152
gtggaagagg agaacaatat gctaaatgtt gttctcgtct cccacnnnnn ncnnnnnnnn       60

nnnnnn                                                                  66


<210> 153
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (56)..(61)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (63)..(76)
<223> a, c, t, g, unknown or other

<400> 153
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccnnnnn       60

ncnnnnnnnn nnnnnn                                                       76


<210> 154
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 154
gtggaagagg agaacaatat gctaaatgtt gttctcgtct cccactgccg ccagctggat       60

ttccc                                                                   65


<210> 155
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 155
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acacctgccg       60

ccagctggat ttccc                                                        75


<210> 156
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 156
gtggaagagg agaacaatat gctaaatgtt gttctcgtct cccacctcct ccacccgacc       60

ccggg                                                                   65


<210> 157
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 157
ggtgtcgaga agaggagaac aatatgctaa atgttgttct cgtctcctcg acaccctcct       60

ccacccgacc ccggg                                                        75


<210> 158
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 158
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccacgagcc ccaaaattaa       60

ataga                                                                   65


<210> 159
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 159
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccacttacc cgaaattttc       60

gaagt                                                                   65


<210> 160
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 160
aacatgagga tcacccatgt cgagccccaa aattaaatag aaacatgagg atcacccatg       60

tc                                                                      62


<210> 161
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 161
aacatgagga tcacccatgt cttacccgaa attttcgaag taacatgagg atcacccatg       60

tc                                                                      62


<210> 162
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 162
aacatgagga tcacccatgt cccattccat tgctctttca aaacatgagg atcacccatg       60

tc                                                                      62


<210> 163
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 163
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccacactgc ccacagatga       60

acaag                                                                   65


<210> 164
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 164
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccactgtac ccgaaggaga       60

gaata                                                                   65


<210> 165
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 165
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccacaaagt ccgaggagga       60

aaaag                                                                   65


<210> 166
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 166
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccacaatac ccgtaggatt       60

aaatc                                                                   65


<210> 167
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 167
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccacaagtt ccggaaaaca       60

aacaa                                                                   65


<210> 168
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 168
aacatgagga tcacccatgt cactgcccac agatgaacaa gaacatgagg atcacccatg       60

tc                                                                      62


<210> 169
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 169
aacatgagga tcacccatgt ctgtacccga aggagagaat aaacatgagg atcacccatg       60

tc                                                                      62


<210> 170
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 170
aacatgagga tcacccatgt caaagtccga ggaggaaaaa gaacatgagg atcacccatg       60

tc                                                                      62


<210> 171
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 171
aacatgagga tcacccatgt caatacccgt aggattaaat caacatgagg atcacccatg       60

tc                                                                      62


<210> 172
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 172
aacatgagga tcacccatgt caagttccgg aaaacaaaca aaacatgagg atcacccatg       60

tc                                                                      62


<210> 173
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (13)..(22)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (44)..(63)
<223> a, c, t, g, unknown or other

<400> 173
acatatatga tannnnnnnn nnaacatgag gatcacccat gtcnnnnnnn nnnnnnnnnn       60

nnn                                                                     63


<210> 174
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (42)..(51)
<223> a, c, t, g, unknown or other

<400> 174
nnnnnnnnnn nnnnnnnnnn aacatgagga tcacccatgt cnnnnnnnnn nttgatcagt       60

atatta                                                                  66


<210> 175
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 175
acatatatga tacaatttga tcagtatatt                                        30


<210> 176
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 176
acatatatga tacaatttga tcagtatatt                                        30


<210> 177
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 177
aacatgagga tcacccatgt c                                                 21


<210> 178
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 178
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccactgccg ccagctggat       60

ttcccaattc tgagtgtgga atagtataac aatatgctaa atgttgttat agtatcccac      120


<210> 179
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 179
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccactgccg ccagctggat       60

ttcccaattc tgagtaacac tctgcgtgga atagtataac aatatgctaa atgttgttat      120

agtatcccac                                                             130


<210> 180
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 180
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccactgccg ccagctggat       60

ttcccaattc tgagtaacac tctgcaatcc aaacagggtt caaccgtgga atagtataac      120

aatatgctaa atgttgttat agtatcccac                                       150


<210> 181
<211> 170
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 181
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccactgccg ccagctggat       60

ttcccaattc tgagtaacac tctgcaatcc aaacagggtt caaccctcca ccttacaggc      120

ctgcagtgga atagtataac aatatgctaa atgttgttat agtatcccac                 170


<210> 182
<211> 190
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 182
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccactgccg ccagctggat       60

ttcccaattc tgagtaacac tctgcaatcc aaacagggtt caaccctcca ccttacaggc      120

ctgcattaca ggacttaaac acatagtgga atagtataac aatatgctaa atgttgttat      180

agtatcccac                                                             190


<210> 183
<211> 210
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 183
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccactgccg ccagctggat       60

ttcccaattc tgagtaacac tctgcaatcc aaacagggtt caaccctcca ccttacaggc      120

ctgcattaca ggacttaaac acataatcca agaatttctt acactgtgga atagtataac      180

aatatgctaa atgttgttat agtatcccac                                       210


<210> 184
<211> 110
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 184
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccacatact gccgccagct       60

ggattgtgga atagtataac aatatgctaa atgttgttat agtatcccac                 110


<210> 185
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 185
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccacactgt acagaatact       60

gccgccagct ggatttccca attctgtgga atagtataac aatatgctaa atgttgttat      120

agtatcccac                                                             130


<210> 186
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 186
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccactcttg tgtctactgt       60

acagaatact gccgccagct ggatttccca attctgagta acactgtgga atagtataac      120

aatatgctaa atgttgttat agtatcccac                                       150


<210> 187
<211> 170
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 187
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccaccgtac ataattcttg       60

tgtctactgt acagaatact gccgccagct ggatttccca attctgagta acactctgca      120

atccagtgga atagtataac aatatgctaa atgttgttat agtatcccac                 170


<210> 188
<211> 190
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 188
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccactgata aaaggcgtac       60

ataattcttg tgtctactgt acagaatact gccgccagct ggatttccca attctgagta      120

acactctgca atccaaacag ggttcgtgga atagtataac aatatgctaa atgttgttat      180

agtatcccac                                                             190


<210> 189
<211> 210
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 189
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccaccttaa gtctttgata       60

aaaggcgtac ataattcttg tgtctactgt acagaatact gccgccagct ggatttccca      120

attctgagta acactctgca atccaaacag ggttcaaccc tccacgtgga atagtataac      180

aatatgctaa atgttgttat agtatcccac                                       210


<210> 190
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 190
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccactgccg ccagctggat       60

ttcccaattc tgagtgtgga agaggagaac aataggctaa acgttgttct cgtctcccac      120


<210> 191
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 191
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccactgccg ccagctggat       60

ttcccaattc tgagtaacac tctgcgtgga agaggagaac aataggctaa acgttgttct      120

cgtctcccac                                                             130


<210> 192
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 192
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccactgccg ccagctggat       60

ttcccaattc tgagtaacac tctgcaatcc aaacagggtt caaccgtgga agaggagaac      120

aataggctaa acgttgttct cgtctcccac                                       150


<210> 193
<211> 170
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 193
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccactgccg ccagctggat       60

ttcccaattc tgagtaacac tctgcaatcc aaacagggtt caaccctcca ccttacaggc      120

ctgcagtgga agaggagaac aataggctaa acgttgttct cgtctcccac                 170


<210> 194
<211> 190
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 194
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccactgccg ccagctggat       60

ttcccaattc tgagtaacac tctgcaatcc aaacagggtt caaccctcca ccttacaggc      120

ctgcattaca ggacttaaac acatagtgga agaggagaac aataggctaa acgttgttct      180

cgtctcccac                                                             190


<210> 195
<211> 210
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 195
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccactgccg ccagctggat       60

ttcccaattc tgagtaacac tctgcaatcc aaacagggtt caaccctcca ccttacaggc      120

ctgcattaca ggacttaaac acataatcca agaatttctt acactgtgga agaggagaac      180

aataggctaa acgttgttct cgtctcccac                                       210


<210> 196
<211> 110
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 196
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccacatact gccgccagct       60

ggattgtgga agaggagaac aataggctaa acgttgttct cgtctcccac                 110


<210> 197
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 197
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccacactgt acagaatact       60

gccgccagct ggatttccca attctgtgga agaggagaac aataggctaa acgttgttct      120

cgtctcccac                                                             130


<210> 198
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 198
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccactcttg tgtctactgt       60

acagaatact gccgccagct ggatttccca attctgagta acactgtgga agaggagaac      120

aataggctaa acgttgttct cgtctcccac                                       150


<210> 199
<211> 170
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 199
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccaccgtac ataattcttg       60

tgtctactgt acagaatact gccgccagct ggatttccca attctgagta acactctgca      120

atccagtgga agaggagaac aataggctaa acgttgttct cgtctcccac                 170


<210> 200
<211> 190
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 200
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccactgata aaaggcgtac       60

ataattcttg tgtctactgt acagaatact gccgccagct ggatttccca attctgagta      120

acactctgca atccaaacag ggttcgtgga agaggagaac aataggctaa acgttgttct      180

cgtctcccac                                                             190


<210> 201
<211> 210
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 201
gtggaagagg agaacaatag gctaaacgtt gttctcgtct cccaccttaa gtctttgata       60

aaaggcgtac ataattcttg tgtctactgt acagaatact gccgccagct ggatttccca      120

attctgagta acactctgca atccaaacag ggttcaaccc tccacgtgga agaggagaac      180

aataggctaa acgttgttct cgtctcccac                                       210


<210> 202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 202
acaaaccgag cggtgtctgt                                                   20


<210> 203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 203
gccattccat tgctctttca                                                   20


<210> 204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 204
tgccgccagc tggatttccc                                                   20


<210> 205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 205
ctgtaccagc cagtcaatta                                                   20


<210> 206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 206
cttctccaca gcccgaagca                                                   20


<210> 207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 207
ctcctccacc cgaccccggg                                                   20


<210> 208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 208
gggtgccaag cagttggtgg                                                   20


<210> 209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 209
cttgtccacc ttgatgccca                                                   20


<210> 210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 210
ttcatccaat ggctggttat                                                   20


<210> 211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 211
caaggccaag ggctcgccag                                                   20


<210> 212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 212
tccaaccacc acaagtttat                                                   20


<210> 213
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 213
tacagaatac tgccgccagc tggatttccc aattctgagt aacactctgc                  50


<210> 214
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 214
gaaaagtttt acaaaccgag cggtgtctgt gagactttca ttcacaccca                  50


<210> 215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 215
ataatttcta ttatattaca                                                   20


<210> 216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 216
atttcaggta agccgaggtt                                                   20


<210> 217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 217
atactgccgc cagctggatt                                                   20


<210> 218
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 218
tgccgccagc tggatttccc aattctgagt aacactctgc aatccaaaca gggttcaacc       60


<210> 219
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 219
tcttgtgtct actgtacaga atactgccgc cagctggatt tcccaattct gagtaacact       60


<210> 220
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 220
tgccgccagc tggatttccc aattctgagt aacactctgc aatccaaaca gggttcaacc       60

ctccacctta caggcctgca ttacaggact taaacacata                            100


<210> 221
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 221
tgataaaagg cgtacataat tcttgtgtct actgtacaga atactgccgc cagctggatt       60

tcccaattct gagtaacact ctgcaatcca aacagggttc                            100


<210> 222
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 222
tgaattagct gtatcgtcaa ggcactcttg cctacgccac cagctccaac caccacaagt       60

ttatattcag tcattttcag caggcctctc tcccgcacct                            100


<210> 223
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 223
atcaaaaaaa taaactctac caagggtgac ggaagtctct acagcaaggc caagggctcg       60

ccagacggcg aacatcaggg gtgcatggtg ggcactgccc                            100


<210> 224
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 224
ctctctgtac cttatcttag tgttactga                                         29


<210> 225
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 225
atttctggca tatttctgaa ggtg                                              24


<210> 226
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 226
acccttcctt tcttaccaca ca                                                22


<210> 227
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 227
cagggtgtcc agatctgatt gtt                                               23


<210> 228
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 228
cttctctttt aaactaaccc atcagagtt                                         29


<210> 229
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 229
caagcagtca gaccaaaata cctactg                                           27


<210> 230
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 230
tcttagcatg cttcgatgtg gcata                                             25


<210> 231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 231
catcaacaag ccagggcctg                                                   20


<210> 232
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 232
gaagaggaaa tgtccgtctc cac                                               23


<210> 233
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 233
aggcctgtaa ggtggaggg                                                    19


<210> 234
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 234
tgaaataacg gcaatttatc cattgcacat ac                                     32


<210> 235
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 235
gggagcagca tggagcctt                                                    19


<210> 236
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 236
tccgaccgta actattcggt gc                                                22


<210> 237
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 237
tgggtgtgaa ccatgagaag tat                                               23


<210> 238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 238
tggcatggac tgtggtcatg                                                   20


<210> 239
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 239
cctaacttat tgcctgggca gtg                                               23


<210> 240
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 240
gcatcagcag tatcttagcc atcaa                                             25


<210> 241
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 241
cagaggctca gcggctcc                                                     18


<210> 242
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 242
tagctgtatc gtcaaggcac tc                                                22


<210> 243
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 243
cacacctgtc tgtgcacttg ta                                                22


<210> 244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 244
cggtccacag ctcaggaacc                                                   20


<210> 245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 245
accagaaggc ggatgatggg                                                   20


<210> 246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 246
ctcagacagc ccatccaacc                                                   20


<210> 247
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 247
tactacttgc ttcctgtagg aatcctc                                           27


<210> 248
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 248
agccctgctg cttcctaact t                                                 21


<210> 249
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 249
accctagttt atttcagcat cagcag                                            26


<210> 250
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1)..(50)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (52)..(100)
<223> a, c, t, g, unknown or other

<400> 250
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn cnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn                            100


<210> 251
<211> 190
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (46)..(95)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (97)..(145)
<223> a, c, t, g, unknown or other

<400> 251
gtggaatagt ataacaatat gctaaatgtt gttatagtat cccacnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnngtgga atagtataac aatatgctaa atgttgttat      180

agtatcccac                                                             190


<210> 252
<211> 46
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 252
tgaatgaaag tctcacagac accgctcagt ttgtaaaact tttctt                      46


<210> 253
<211> 24
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 253
tcacagacac cgctcagttt gtaa                                              24


<210> 254
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 254
cagacaccgc tcagtttgta aaact                                             25


<210> 255
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 255
ggaaatccag ctagcggcag tattc                                             25


