                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
 
<120>  Anti-CD33 and NKG2D Ligand Chimeras for Treatment of Myeloid 
       Malignancies

<130>  01001/006138-WO0

<150>  62/722,642
<151>  2018-08-24

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  190
<212>  PRT
<213>  Human

<400>  1

Trp Val Asp Thr His Cys Leu Cys Tyr Asp Phe Ile Ile Thr Pro Lys 
1               5                   10                  15      


Ser Arg Pro Glu Pro Gln Trp Cys Glu Val Gln Gly Leu Val Asp Glu 
            20                  25                  30          


Arg Pro Phe Leu His Tyr Asp Cys Val Asn His Lys Ala Lys Ala Phe 
        35                  40                  45              


Ala Ser Leu Gly Lys Lys Val Asn Val Thr Lys Thr Trp Glu Glu Gln 
    50                  55                  60                  


Thr Glu Thr Leu Arg Asp Val Val Asp Phe Leu Lys Gly Gln Leu Leu 
65                  70                  75                  80  


Asp Ile Gln Val Glu Asn Leu Ile Pro Ile Glu Pro Leu Thr Leu Gln 
                85                  90                  95      


Ala Arg Met Ser Cys Glu His Glu Ala His Gly His Gly Arg Gly Ser 
            100                 105                 110         


Trp Gln Phe Leu Phe Asn Gly Gln Lys Phe Leu Leu Phe Asp Ser Asn 
        115                 120                 125             


Asn Arg Lys Trp Thr Ala Leu His Pro Gly Ala Lys Lys Met Thr Glu 
    130                 135                 140                 


Lys Trp Glu Lys Asn Arg Asp Val Thr Met Phe Phe Gln Lys Ile Ser 
145                 150                 155                 160 


Leu Gly Asp Cys Lys Met Trp Leu Glu Glu Phe Leu Met Tyr Trp Glu 
                165                 170                 175     


Gln Met Leu Asp Pro Thr Lys Pro Pro Ser Leu Ala Pro Gly 
            180                 185                 190 


<210>  2
<211>  192
<212>  PRT
<213>  Human

<400>  2

Gly Arg Ala Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro 
1               5                   10                  15      


Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp 
            20                  25                  30          


Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro 
        35                  40                  45              


Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala 
    50                  55                  60                  


Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu 
65                  70                  75                  80  


Arg Asp Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu 
                85                  90                  95      


Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly 
            100                 105                 110         


Ser Trp Gln Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser 
        115                 120                 125             


Glu Lys Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys 
    130                 135                 140                 


Glu Lys Trp Glu Asn Asp Lys Val Val Ala Met Ser Phe His Tyr Phe 
145                 150                 155                 160 


Ser Met Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met 
                165                 170                 175     


Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Leu Ala Met Ser Ser 
            180                 185                 190         


<210>  3
<211>  188
<212>  PRT
<213>  Human

<400>  3

Asp Ala His Ser Leu Trp Tyr Asn Phe Thr Ile Ile His Leu Pro Arg 
1               5                   10                  15      


His Gly Gln Gln Trp Cys Glu Val Gln Ser Gln Val Asp Gln Lys Asn 
            20                  25                  30          


Phe Leu Ser Tyr Asp Cys Gly Ser Asp Lys Val Leu Ser Met Gly His 
        35                  40                  45              


Leu Glu Glu Gln Leu Tyr Ala Thr Asp Ala Trp Gly Lys Gln Leu Glu 
    50                  55                  60                  


Met Leu Arg Glu Val Gly Gln Arg Leu Arg Leu Glu Leu Ala Asp Thr 
65                  70                  75                  80  


Glu Leu Glu Asp Phe Thr Pro Ser Gly Pro Leu Thr Leu Gln Val Arg 
                85                  90                  95      


Met Ser Cys Glu Cys Glu Ala Asp Gly Tyr Ile Arg Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Arg Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg 
        115                 120                 125             


Lys Trp Thr Val Val His Ala Gly Ala Arg Arg Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Lys Asp Ser Gly Leu Thr Thr Phe Phe Lys Met Val Ser Met Arg 
145                 150                 155                 160 


Asp Cys Lys Ser Trp Leu Arg Asp Phe Leu Met His Arg Lys Lys Arg 
                165                 170                 175     


Leu Glu Pro Thr Ala Pro Pro Thr Met Ala Pro Gly 
            180                 185             


<210>  4
<211>  195
<212>  PRT
<213>  Human

<400>  4

His Ser Leu Cys Phe Asn Phe Thr Ile Lys Ser Leu Ser Arg Pro Gly 
1               5                   10                  15      


Gln Pro Trp Cys Glu Ala Gln Val Phe Leu Asn Lys Asn Leu Phe Leu 
            20                  25                  30          


Gln Tyr Asn Ser Asp Asn Asn Met Val Lys Pro Leu Gly Leu Leu Gly 
        35                  40                  45              


Lys Lys Val Tyr Ala Thr Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu 
    50                  55                  60                  


Gly Glu Val Gly Arg Asp Leu Arg Met Leu Leu Cys Asp Ile Lys Pro 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Asp Pro Ser Thr Leu Gln Val Glu Met Phe Cys 
                85                  90                  95      


Gln Arg Glu Ala Glu Arg Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr 
            100                 105                 110         


Asn Gly Glu Lys Ser Leu Leu Phe Asp Ala Met Asn Met Thr Trp Thr 
        115                 120                 125             


Val Ile Asn His Glu Ala Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp 
    130                 135                 140                 


Arg Gly Leu Glu Lys Tyr Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp 
145                 150                 155                 160 


His Trp Leu Arg Glu Phe Leu Gly His Trp Glu Ala Met Pro Glu Pro 
                165                 170                 175     


Thr Val Ser Pro Val Asn Ala Ser Asp Ile His Trp Ser Ser Ser Ser 
            180                 185                 190         


Leu Pro Asp 
        195 


<210>  5
<211>  198
<212>  PRT
<213>  Human

<400>  5

Gly Leu Ala Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro 
1               5                   10                  15      


Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp 
            20                  25                  30          


Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Ser Lys Thr Val Thr Pro 
        35                  40                  45              


Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala 
    50                  55                  60                  


Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu 
65                  70                  75                  80  


Leu Asp Ile Gln Leu Glu Asn Tyr Ile Pro Lys Glu Pro Leu Thr Leu 
                85                  90                  95      


Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Gly Ser Gly 
            100                 105                 110         


Ser Trp Gln Leu Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser 
        115                 120                 125             


Glu Asn Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys 
    130                 135                 140                 


Glu Lys Trp Glu Asn Asp Lys Asp Met Thr Met Ser Phe His Tyr Ile 
145                 150                 155                 160 


Ser Met Gly Asp Cys Thr Gly Trp Leu Glu Asp Phe Leu Met Gly Met 
                165                 170                 175     


Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Pro Thr Met Ser Ser 
            180                 185                 190         


Gly Thr Ala Gln Pro Arg 
        195             


<210>  6
<211>  193
<212>  PRT
<213>  Human

<400>  6

Arg Arg Asp Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro 
1               5                   10                  15      


Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp 
            20                  25                  30          


Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro 
        35                  40                  45              


Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Met Ala Trp Lys Ala 
    50                  55                  60                  


Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu 
65                  70                  75                  80  


Leu Asp Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu 
                85                  90                  95      


Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly 
            100                 105                 110         


Ser Trp Gln Phe Ser Ile Asp Gly Gln Thr Phe Leu Leu Phe Asp Ser 
        115                 120                 125             


Glu Lys Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys 
    130                 135                 140                 


Glu Lys Trp Glu Asn Asp Lys Asp Val Ala Met Ser Phe His Tyr Ile 
145                 150                 155                 160 


Ser Met Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met 
                165                 170                 175     


Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Leu Ala Met Ser Ser 
            180                 185                 190         


Gly 
    


<210>  7
<211>  284
<212>  PRT
<213>  Human

<400>  7

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser Gly Lys Val Leu Val Leu Gln Ser His Trp 
        275                 280                 


<210>  8
<211>  287
<212>  PRT
<213>  Human

<400>  8

Ala Glu Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp 
1               5                   10                  15      


Glu Ser Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Ala Glu Asp Val Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr 
    50                  55                  60                  


Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val 
                85                  90                  95      


Cys Glu Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala 
145                 150                 155                 160 


Met Gln Ala Asp Cys Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Ala Ile Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Cys Ser 
            180                 185                 190         


Glu Val Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe 
        195                 200                 205             


Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu 
    210                 215                 220                 


Ser His Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly 
225                 230                 235                 240 


Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln 
                245                 250                 255     


Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr His Pro 
            260                 265                 270         


Val Pro Ser Gly Lys Val Leu Val Leu Gln Ser Gln Arg Thr Asp 
        275                 280                 285         


<210>  9
<211>  197
<212>  PRT
<213>  Murine

<400>  9

Leu Asp Asp Ala His Ser Leu Arg Cys Asn Leu Thr Ile Lys Ala Pro 
1               5                   10                  15      


Thr Pro Ala Asp Glu Val Lys Cys Phe Val Gly Glu Ile Leu Ile Leu 
            20                  25                  30          


His Leu Ser Asn Ile Asn Lys Thr Met Thr Ser Gly Asp Pro Gly Glu 
        35                  40                  45              


Thr Ala Asn Ala Thr Glu Val Gly Glu Cys Leu Thr Gln Pro Leu Lys 
    50                  55                  60                  


Asp Leu Cys Gln Lys Leu Arg Asp Lys Val Ser Asn Thr Lys Val Asp 
65                  70                  75                  80  


Thr His Lys Thr Asn Gly Tyr Pro His Leu Gln Val Thr Met Ile Tyr 
                85                  90                  95      


Pro Gln Ser Gln Gly Gln Thr Pro Ser Ala Thr Trp Glu Phe Asn Ile 
            100                 105                 110         


Ser Asp Ser Tyr Phe Phe Thr Phe Tyr Thr Glu Ile Met Ser Trp Arg 
        115                 120                 125             


Ser Ala Asn Asp Glu Ser Gly Val Ile Met Asn Lys Trp Lys Asp Asp 
    130                 135                 140                 


Gly Glu Phe Val Lys Gln Leu Lys Phe Leu Ile His Gly Cys Ser Gln 
145                 150                 155                 160 


Lys Met Asp Glu Phe Leu Lys Gln Ser Lys Glu Lys Pro Arg Ser Thr 
                165                 170                 175     


Ser Arg Ser Pro Ser Ile Thr Gln Leu Thr Ser Thr Ser Pro Leu Pro 
            180                 185                 190         


Pro Thr Ser His Ser 
        195         


<210>  10
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser 
            20                  25                  30          


Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  11
<211>  17
<212>  PRT
<213>  Murine

<400>  11

Lys Ser Ser Gln Ser Val Phe Phe Ser Ser Ser Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  12
<211>  7
<212>  PRT
<213>  Murine

<400>  12

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  13
<211>  8
<212>  PRT
<213>  Murine

<400>  13

His Gln Tyr Leu Ser Ser Arg Thr 
1               5               


<210>  14
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
gagatcgtgc tgacccagag ccccggcagc ctggccgtga gccccggcga gagggtgacc       60

atgagctgca agagcagcca gagcgtgttc ttcagcagca gccagaagaa ctacctggcc      120

tggtaccagc agatccccgg ccagagcccc aggctgctga tctactgggc cagcaccagg      180

gagagcggcg tgcccgacag gttcaccggc agcggcagcg gcaccgactt caccctgacc      240

atcagcagcg tgcagcccga ggacctggcc atctactact gccaccagta cctgagcagc      300

aggaccttcg gccagggcac caagctggag atcaagagg                             339


<210>  15
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  16
<211>  5
<212>  PRT
<213>  Murine

<400>  16

Ser Tyr Tyr Ile His 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  Murine

<400>  17

Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  9
<212>  PRT
<213>  Murine

<400>  18

Glu Val Arg Leu Arg Tyr Phe Asp Val 
1               5                   


<210>  19
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
caggtgcagc tgcagcagcc cggcgccgag gtggtgaagc ccggcgccag cgtgaagatg       60

agctgcaagg ccagcggcta caccttcacc agctactaca tccactggat caagcagacc      120

cccggccagg gcctggagtg ggtgggcgtg atctaccccg gcaacgacga catcagctac      180

aaccagaagt tccagggcaa ggccaccctg accgccgaca agagcagcac caccgcctac      240

atgcagctga gcagcctgac cagcgaggac agcgccgtgt actactgcgc cagggaggtg      300

aggctgaggt acttcgacgt gtggggccag ggcaccaccg tgaccgtgag cagc            354


<210>  20
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Phe Phe Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Ile Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr 
            100                 105                 110         


Tyr Cys His Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 


Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Pro Gly Ala 
145                 150                 155                 160 


Glu Val Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro 
            180                 185                 190         


Gly Gln Gly Leu Glu Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp 
        195                 200                 205             


Ile Ser Tyr Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp 
    210                 215                 220                 


Lys Ser Ser Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe 
                245                 250                 255     


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Ser Ser 
            260                 265                 270         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Trp Val Asp Thr His Cys Leu Cys Tyr Asp Phe Ile Ile Thr Pro Lys 
    290                 295                 300                 


Ser Arg Pro Glu Pro Gln Trp Cys Glu Val Gln Gly Leu Val Asp Glu 
305                 310                 315                 320 


Arg Pro Phe Leu His Tyr Asp Cys Val Asn His Lys Ala Lys Ala Phe 
                325                 330                 335     


Ala Ser Leu Gly Lys Lys Val Asn Val Thr Lys Thr Trp Glu Glu Gln 
            340                 345                 350         


Thr Glu Thr Leu Arg Asp Val Val Asp Phe Leu Lys Gly Gln Leu Leu 
        355                 360                 365             


Asp Ile Gln Val Glu Asn Leu Ile Pro Ile Glu Pro Leu Thr Leu Gln 
    370                 375                 380                 


Ala Arg Met Ser Cys Glu His Glu Ala His Gly His Gly Arg Gly Ser 
385                 390                 395                 400 


Trp Gln Phe Leu Phe Asn Gly Gln Lys Phe Leu Leu Phe Asp Ser Asn 
                405                 410                 415     


Asn Arg Lys Trp Thr Ala Leu His Pro Gly Ala Lys Lys Met Thr Glu 
            420                 425                 430         


Lys Trp Glu Lys Asn Arg Asp Val Thr Met Phe Phe Gln Lys Ile Ser 
        435                 440                 445             


Leu Gly Asp Cys Lys Met Trp Leu Glu Glu Phe Leu Met Tyr Trp Glu 
    450                 455                 460                 


Gln Met Leu Asp Pro Thr Lys Pro Pro Ser Leu Ala Pro Gly Glu Gln 
465                 470                 475                 480 


Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
                485                 490                 


<210>  21
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Phe Phe Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Ile Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr 
            100                 105                 110         


Tyr Cys His Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 


Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Pro Gly Ala 
145                 150                 155                 160 


Glu Val Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro 
            180                 185                 190         


Gly Gln Gly Leu Glu Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp 
        195                 200                 205             


Ile Ser Tyr Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp 
    210                 215                 220                 


Lys Ser Ser Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe 
                245                 250                 255     


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Ser Ser 
            260                 265                 270         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Pro Trp Val Asp Thr His Cys Leu Cys Tyr Asp Phe Ile Ile Thr Pro 
    290                 295                 300                 


Lys Ser Arg Pro Glu Pro Gln Trp Cys Glu Val Gln Gly Leu Val Asp 
305                 310                 315                 320 


Glu Arg Pro Phe Leu His Tyr Asp Cys Val Asn His Lys Ala Lys Ala 
                325                 330                 335     


Phe Ala Ser Leu Gly Lys Lys Val Asn Val Thr Lys Thr Trp Glu Glu 
            340                 345                 350         


Gln Thr Glu Thr Leu Arg Asp Val Val Asp Phe Leu Lys Gly Gln Leu 
        355                 360                 365             


Leu Asp Ile Gln Val Glu Asn Leu Ile Pro Ile Glu Pro Leu Thr Leu 
    370                 375                 380                 


Gln Ala Arg Met Ser Cys Glu His Glu Ala His Gly His Gly Arg Gly 
385                 390                 395                 400 


Ser Trp Gln Phe Leu Phe Asn Gly Gln Lys Phe Leu Leu Phe Asp Ser 
                405                 410                 415     


Asn Asn Arg Lys Trp Thr Ala Leu His Pro Gly Ala Lys Lys Met Thr 
            420                 425                 430         


Glu Lys Trp Glu Lys Asn Arg Asp Val Thr Met Phe Phe Gln Lys Ile 
        435                 440                 445             


Ser Leu Gly Asp Cys Lys Met Trp Leu Glu Glu Phe Leu Met Tyr Trp 
    450                 455                 460                 


Glu Gln Met Leu Asp Pro Thr Lys Pro Pro Ser Leu Ala Pro Gly Glu 
465                 470                 475                 480 


Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His His His 
                485                 490                 495 


<210>  22
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Trp Val Asp Thr His Cys Leu Cys Tyr Asp Phe Ile 
            20                  25                  30          


Ile Thr Pro Lys Ser Arg Pro Glu Pro Gln Trp Cys Glu Val Gln Gly 
        35                  40                  45              


Leu Val Asp Glu Arg Pro Phe Leu His Tyr Asp Cys Val Asn His Lys 
    50                  55                  60                  


Ala Lys Ala Phe Ala Ser Leu Gly Lys Lys Val Asn Val Thr Lys Thr 
65                  70                  75                  80  


Trp Glu Glu Gln Thr Glu Thr Leu Arg Asp Val Val Asp Phe Leu Lys 
                85                  90                  95      


Gly Gln Leu Leu Asp Ile Gln Val Glu Asn Leu Ile Pro Ile Glu Pro 
            100                 105                 110         


Leu Thr Leu Gln Ala Arg Met Ser Cys Glu His Glu Ala His Gly His 
        115                 120                 125             


Gly Arg Gly Ser Trp Gln Phe Leu Phe Asn Gly Gln Lys Phe Leu Leu 
    130                 135                 140                 


Phe Asp Ser Asn Asn Arg Lys Trp Thr Ala Leu His Pro Gly Ala Lys 
145                 150                 155                 160 


Lys Met Thr Glu Lys Trp Glu Lys Asn Arg Asp Val Thr Met Phe Phe 
                165                 170                 175     


Gln Lys Ile Ser Leu Gly Asp Cys Lys Met Trp Leu Glu Glu Phe Leu 
            180                 185                 190         


Met Tyr Trp Glu Gln Met Leu Asp Pro Thr Lys Pro Pro Ser Leu Ala 
        195                 200                 205             


Pro Gly Thr Thr Gln Pro Ser Ser Ser Ala Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
225                 230                 235                 240 


Pro Gly Ser Leu Ala Val Ser Pro Gly Glu Arg Val Thr Met Ser Cys 
                245                 250                 255     


Lys Ser Ser Gln Ser Val Phe Phe Ser Ser Ser Gln Lys Asn Tyr Leu 
            260                 265                 270         


Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        275                 280                 285             


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser 
    290                 295                 300                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro Glu 
305                 310                 315                 320 


Asp Leu Ala Ile Tyr Tyr Cys His Gln Tyr Leu Ser Ser Arg Thr Phe 
                325                 330                 335     


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser Thr Ser Gly Ser 
            340                 345                 350         


Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu 
        355                 360                 365             


Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Met 
    370                 375                 380                 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp 
385                 390                 395                 400 


Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val Gly Val Ile Tyr 
                405                 410                 415     


Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe Gln Gly Lys Ala 
            420                 425                 430         


Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr Met Gln Leu Ser 
        435                 440                 445             


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Val 
    450                 455                 460                 


Arg Leu Arg Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
465                 470                 475                 480 


Ser Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu His His His His 
                485                 490                 495     


His His 
        


<210>  23
<211>  20
<212>  PRT
<213>  Human

<400>  23

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Ser Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser 
            


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Ser Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Pro 
            20  


<210>  27
<211>  10
<212>  PRT
<213>  Human

<400>  27

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

His His His His His His 
1               5       


<210>  29
<211>  201
<212>  PRT
<213>  Murine

<400>  29

Leu Asp Asp Ala His Ser Leu Arg Cys Asn Leu Thr Ile Lys Asp Pro 
1               5                   10                  15      


Thr Pro Ala Asp Pro Leu Trp Tyr Glu Ala Lys Cys Leu Val Asp Glu 
            20                  25                  30          


Ile Leu Ile Leu His Leu Ser Asn Ile Asn Lys Thr Met Thr Ser Gly 
        35                  40                  45              


Asp Pro Gly Glu Thr Ala Asn Ala Thr Glu Val Gly Glu Cys Leu Thr 
    50                  55                  60                  


Gln Pro Leu Lys Asp Leu Cys Gln Lys Leu Arg Asn Lys Val Ser Asn 
65                  70                  75                  80  


Thr Lys Val Asp Thr His Lys Thr Asn Gly Tyr Pro His Leu Gln Val 
                85                  90                  95      


Thr Met Ile Tyr Leu Gln Ser Gln Gly Gln Ile Pro Ser Ala Thr Trp 
            100                 105                 110         


Glu Phe Asn Ile Ser Asp Ser Tyr Phe Phe Thr Phe Tyr Thr Glu Asn 
        115                 120                 125             


Met Ser Trp Arg Ser Ala Asn Asp Glu Ser Gly Val Ile Met Asn Lys 
    130                 135                 140                 


Trp Lys Asp Asp Gly Glu Phe Val Lys Arg Leu Lys Phe Leu Ile Pro 
145                 150                 155                 160 


Glu Cys Arg Gln Glu Val Asp Glu Phe Leu Lys Gln Pro Lys Glu Lys 
                165                 170                 175     


Pro Arg Ser Thr Ser Arg Ser Pro Ser Ile Thr Gln Leu Thr Ser Thr 
            180                 185                 190         


Ser Pro Leu Pro Pro Pro Ser His Ser 
        195                 200     


<210>  30
<211>  201
<212>  PRT
<213>  Murine

<400>  30

Leu Asp Asp Ala His Ser Leu Arg Cys Asn Leu Thr Ile Lys Asp Pro 
1               5                   10                  15      


Thr Pro Ala Asp Pro Leu Trp Tyr Glu Ala Lys Cys Phe Val Gly Glu 
            20                  25                  30          


Ile Leu Ile Leu His Leu Ser Asn Ile Asn Lys Thr Met Thr Ser Gly 
        35                  40                  45              


Asp Pro Gly Glu Thr Ala Asn Ala Thr Glu Val Lys Lys Cys Leu Thr 
    50                  55                  60                  


Gln Pro Leu Lys Asn Leu Cys Gln Lys Leu Arg Asn Lys Val Ser Asn 
65                  70                  75                  80  


Thr Lys Val Asp Thr His Lys Thr Asn Gly Tyr Pro His Leu Gln Val 
                85                  90                  95      


Thr Met Ile Tyr Pro Gln Ser Gln Gly Arg Thr Pro Ser Ala Thr Trp 
            100                 105                 110         


Glu Phe Asn Ile Ser Asp Ser Tyr Phe Phe Thr Phe Tyr Thr Glu Asn 
        115                 120                 125             


Met Ser Trp Arg Ser Ala Asn Asp Glu Ser Gly Val Ile Met Asn Lys 
    130                 135                 140                 


Trp Lys Asp Asp Gly Glu Phe Val Lys Gln Leu Lys Phe Leu Ile His 
145                 150                 155                 160 


Glu Cys Ser Gln Lys Met Asp Glu Phe Leu Lys Gln Ser Lys Glu Lys 
                165                 170                 175     


Pro Arg Ser Thr Ser Arg Ser Pro Ser Ile Thr Gln Leu Thr Ser Thr 
            180                 185                 190         


Ser Pro Leu Pro Pro Pro Ser His Ser 
        195                 200     


<210>  31
<211>  199
<212>  PRT
<213>  Murine

<400>  31

Leu Asp Asp Ala His Ser Leu Arg Cys Asn Leu Thr Ile Lys Ala Pro 
1               5                   10                  15      


Thr Pro Ala Asp Pro Leu Trp Tyr Glu Ala Lys Cys Leu Val Asp Glu 
            20                  25                  30          


Ile Leu Ile Leu His Leu Ser Asn Ile Asn Lys Thr Met Thr Ser Gly 
        35                  40                  45              


Asp Pro Gly Glu Thr Ala Asn Ala Thr Glu Val Gly Glu Cys Leu Thr 
    50                  55                  60                  


Gln Pro Val Asn Asp Leu Cys Gln Lys Leu Arg Asp Lys Val Ser Asn 
65                  70                  75                  80  


Thr Lys Val Asp Thr His Lys Thr Asn Gly Tyr Pro His Leu Gln Val 
                85                  90                  95      


Thr Met Ile Tyr Pro Gln Ser Gln Gly Gln Thr Pro Ser Ala Thr Trp 
            100                 105                 110         


Glu Phe Asn Ile Ser Asp Ser Tyr Phe Phe Thr Phe Tyr Thr Glu Asn 
        115                 120                 125             


Met Ser Trp Arg Ser Ala Asn Asp Glu Ser Gly Val Ile Met Asn Lys 
    130                 135                 140                 


Trp Asn Asp Asp Gly Asp Leu Val Gln Arg Leu Lys Tyr Phe Ile Pro 
145                 150                 155                 160 


Glu Cys Arg Gln Lys Ile Asp Glu Phe Leu Lys Gln Ser Lys Glu Lys 
                165                 170                 175     


Pro Arg Ser Thr Ser Arg Ser Pro Ser Ile Thr Gln Leu Thr Ser Thr 
            180                 185                 190         


Ser Pro Leu Pro Pro Pro Ser 
        195                 


<210>  32
<211>  197
<212>  PRT
<213>  Murine

<400>  32

Leu Asp Asp Ala His Ser Leu Arg Cys Asn Leu Thr Ile Lys Asp Pro 
1               5                   10                  15      


Thr Ser Ala Asp Leu Pro Trp Cys Asp Val Lys Cys Ser Val Asp Glu 
            20                  25                  30          


Ile Thr Ile Leu His Leu Asn Asn Ile Asn Lys Thr Met Thr Ser Gly 
        35                  40                  45              


Asp Pro Gly Lys Met Ala Asn Ala Thr Gly Lys Cys Leu Thr Gln Pro 
    50                  55                  60                  


Leu Asn Asp Leu Cys Gln Glu Leu Arg Asp Lys Val Ser Asn Thr Lys 
65                  70                  75                  80  


Val Asp Thr His Lys Thr Asn Gly Tyr Pro His Leu Gln Val Thr Met 
                85                  90                  95      


Ile Tyr Pro Gln Ser Gln Gly Gln Thr Pro Ser Ala Thr Trp Glu Phe 
            100                 105                 110         


Asn Ile Ser Asp Ser Tyr Phe Phe Thr Phe Tyr Thr Glu Asn Met Ser 
        115                 120                 125             


Trp Arg Ser Ala Asn Asp Glu Ser Gly Val Ile Met Asn Lys Trp Lys 
    130                 135                 140                 


Asp Asp Gly Asp Leu Val Gln Gln Leu Lys Tyr Phe Ile Pro Gln Cys 
145                 150                 155                 160 


Arg Gln Lys Ile Asp Glu Phe Leu Lys Gln Ser Lys Glu Lys Pro Arg 
                165                 170                 175     


Ser Thr Ser Arg Ser Pro Ser Ile Thr Gln Leu Thr Ser Thr Ser Pro 
            180                 185                 190         


Leu Pro Pro Pro Ser 
        195         


<210>  33
<211>  227
<212>  PRT
<213>  Murine

<400>  33

Thr Gly Thr Asp Ser Leu Ser Cys Glu Leu Thr Phe Asn His Arg Thr 
1               5                   10                  15      


Leu His Gly Gln Cys Ser Val Asn Gly Lys Thr Leu Leu Asp Phe Gly 
            20                  25                  30          


Asp Lys Lys His Glu Gly Asn Ala Thr Glu Met Cys Ala Asp Leu Ser 
        35                  40                  45              


Gln Ser Leu Arg Glu Leu Ser Glu Gly Met Arg Asn Gln Gln Ser Gly 
    50                  55                  60                  


Asn Asp Ala Leu Asn Val Thr Thr Gln Ser Gln Tyr Asn Gln Gly Glu 
65                  70                  75                  80  


Phe Ile Gly Gly Phe Trp Ala Ile Asn Thr Asp Glu Gln His Ser Ile 
                85                  90                  95      


Tyr Phe Tyr Pro Leu Asn Met Thr Trp Arg Glu Ser His Ser Asp Asn 
            100                 105                 110         


Ser Ser Ala Met Glu His Trp Lys Asn Lys Asn Leu Glu Lys Asp Ile 
        115                 120                 125             


Arg Asn Val Leu Ile Ile Tyr Phe Ser Arg Cys Leu Asn Lys Leu Ser 
    130                 135                 140                 


Pro His Phe Arg Glu Met Pro Lys Ser Lys Ile Lys Val Leu Asp Thr 
145                 150                 155                 160 


Thr Gln Asn Thr Asn Thr Thr Gln Ile His Pro Thr Val Asn Asn Ser 
                165                 170                 175     


Gln His Asn Ser Asp Thr Gln Gly Leu Ser Phe Thr Trp Ile Val Ile 
            180                 185                 190         


Ile Cys Ile Gly Gly Ile Val Ser Phe Met Ala Phe Met Val Phe Ala 
        195                 200                 205             


Trp Cys Met Leu Lys Lys Lys Lys Gly Ala Leu Cys Cys Ser Ser Ser 
    210                 215                 220                 


Ser Thr Thr 
225         


<210>  34
<211>  160
<212>  PRT
<213>  Murine

<400>  34

Leu Asn Cys Lys Leu Thr Val Lys Tyr Arg Thr Leu Gln Gly Leu Cys 
1               5                   10                  15      


Ser Val Asn Gly Lys Thr Phe Leu Asp Phe Gly Asp Glu Asn His Glu 
            20                  25                  30          


Gly Asn Ala Thr Met Leu Cys Pro Ala Leu Tyr Gln Ser Leu Thr Asp 
        35                  40                  45              


Ile Ser Glu Val Met Trp Ser Leu Gln Ser Gly Asn Asp Ala Leu Asn 
    50                  55                  60                  


Val Thr Thr Arg Ser Gln Tyr Tyr Gln Gly Glu Phe Ile Asp Gly Phe 
65                  70                  75                  80  


Trp Asp Ile Asn Thr Asp Glu Gln His Ser Ile Tyr Val Tyr Pro Leu 
                85                  90                  95      


Asn Lys Thr Trp Arg Glu Ser His Ser Asp Asn Ser Ser Ala Met Glu 
            100                 105                 110         


Gln Trp Lys Asn Lys Asn Leu Glu Lys Asp Ile Arg Asn Val Leu Met 
        115                 120                 125             


Val Asp Phe Ser Cys Cys Leu Asn Lys Ser Ser Pro His Phe Arg Glu 
    130                 135                 140                 


Met Pro Thr Leu Pro Thr Thr Ala Ala His Val Asp Gln Pro Arg Ser 
145                 150                 155                 160 


