                         SEQUENCE LISTING

<110>  BioInvent International AB
       Transgene SA
 
<120>  NOVEL ANTIBODIES AND NUCLEOTIDE SEQUENCES, AND USES THEREOF

<130>  BI86

<150>  EP18192311.1
<151>  2018-09-03

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X in position 2 is S or K

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X in position 3 is D, S or A

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X in position 5 is Y, S or A

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X in position 7 is S or N

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X in position 9 is V or I

<400>  1

Phe Xaa Xaa Tyr Xaa Met Xaa Trp Xaa Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  2
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X in position 3 is D or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X in position 3 is Y, S or A

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X in position 3 is S or N

<400>  2

Phe Ser Xaa Tyr Xaa Met Xaa Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  3
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X in position 3 is D or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X in position 5 is Y or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X in position 5 is S or N

<400>  3

Phe Ser Xaa Tyr Xaa Met Xaa Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  4
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X in position 2 is G or A

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X in position 5 is W, G or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X in position 6 is S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X in position 7 is S or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X in position 8 is R or G

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X in position 9 is D, S or Y

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X in position 10 is K, T or I

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X in position 11 is G, Y, H or D

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X in position 12 is Y or F

<400>  4

Ser Xaa Ile Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  5
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X in position 2 is G or A

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X in position 5 is W, G or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X in position 6 is S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X in position 7 is S or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X in position 8 is R or G

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X in position 9 is D, S or Y

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X in position 10 is K, T or I

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X in position 11 is G, Y, H or D

<400>  5

Ser Xaa Ile Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  6
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X in position 2 is G or A

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X in position 5 is W or G

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X in position 7 is S or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X in position 8 is R or G

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X in position 9 is D or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X in position 10 is K or T

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X in position 11 is G or Y, H or D

<400>  6

Ser Xaa Ile Ser Xaa Ser Xaa Xaa Xaa Xaa Xaa Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X in position 1 is T or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X in position 2 is T or R

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X in position 3 is D, Y or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X in position 4 is L, R, S, or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X in position 5 is A, V, S or Y

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X in position 6 is R, E, G or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X in position 6 is Y, M, L or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X in position 8 is N, H, Y or none

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X in position 9 is Q, D or none

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X in position 10 is W, A, D or none

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X in position 11 is L, F, R or none

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X in position 12 is A, D, G or none

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X in position 13 is D, I, M or none

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X in position 14 is D or none

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X in position 15 is V or none

<400>  7

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X in position 1 is T or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X in position 2 is T or R

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X in position 4 is L or R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X in position 5 is A or V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X in position 6 is R or E

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X in position 7 is Y or M

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X in position 8 is N or none

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X in position 9 is Q or none

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X in position 10 is W or none

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X in position 11 is L or none

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X in position 12 is A or none

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X in position 13 is D or none

<400>  8

Xaa Xaa Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X in position 2 is T or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X in position 10 is A or S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X in position 11 is G or N

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X in position 13 is D or V

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X in position 14i s V or Y

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X in position 15 i s H or none

<400>  9

Cys Xaa Gly Ser Ser Ser Asn Ile Gly Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  15  


<210>  11
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X in position 1 is G, R, or D

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X in position 3 is D, N, or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X in position 4 is N, Q or K

<400>  11

Xaa Asn Xaa Xaa Arg Pro Ser 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X in position 1 is G or R

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X in position 3 is D or N

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X in position 3 is N or Q

<400>  12

Xaa Asn Xaa Xaa Arg Pro Ser 
1               5           


<210>  13
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X in position 2 is A or Q

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X in position 3 is V, A or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X in position 4 is W or Y

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X in position 6 is D or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X in position 9 is N or S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X in position 11 is V, W or P

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X in position 13 is V or none

<400>  13

Cys Xaa Xaa Xaa Asp Xaa Ser Leu Xaa Gly Xaa Val Xaa 
1               5                   10              


<210>  14
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X in position 3 is V or A

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X in position 11 is V or W

<400>  14

Cys Ala Xaa Trp Asp Asp Ser Leu Asn Gly Xaa Val 
1               5                   10          


<210>  15
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  15

Phe Ser Asp Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  16
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Gly Ile Ser Trp Ser Ser Arg Asp Lys Gly Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  17
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Thr Asp Leu Ala Arg Tyr 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Asn Asp Asn Arg Pro Ser 
1               5           


<210>  19
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  19

Cys Ala Val Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10          


<210>  20
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Ser Arg Asp Lys Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Asp Leu Ala Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  21
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asp Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  22
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  22

Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  23
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  24
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Arg Asp Arg Val Glu Met Asn Gln Trp Leu Ala Asp 
1               5                   10              


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  26
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  26

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10          


<210>  27
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Val Glu Met Asn Gln Trp Leu Ala Asp Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  28
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  29
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  29

Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  30
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Gly Ile Ser Gly Ser Gly Gly Tyr Ile His Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  31
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Thr Tyr Ser Ser Gly Leu His Asp Ala Phe Asp Ile 
1               5                   10              


<210>  32
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  33
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Tyr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Ser Ser Gly Leu His Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  35
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  35

Phe Lys Ala Tyr Ser Met Ser Trp Ile Arg Gln Ala Pro Gly 
1               5                   10                  


<210>  36
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Gly Ile Ser Asn Thr Gly Gly Ser Thr Asp Phe Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  37
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Arg Leu Gly Tyr Ser Gly Tyr Asp Asp Arg Gly Met Asp Val 
1               5                   10                  15  


<210>  38
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  38

Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10                  


<210>  39
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  40
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  40

Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Pro Val Val 
1               5                   10              


<210>  41
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Ala Tyr 
            20                  25                  30          


Ser Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Asn Thr Gly Gly Ser Thr Asp Phe Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Ser Gly Tyr Asp Asp Arg Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  42
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  43
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  44
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  45
<211>  1335
<212>  DNA
<213>  Homo sapiens

<400>  45
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctgggt ccgccaggct      120

cccgggaagg ggctggagtg ggtctcaggc attagttgga gtagtcgtga caaaggctat      180

gcggactctg tgaagggccg tttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtac cacagatctc      300

gctaggtact ggggccaggg tacactggtc accgtgagct cagcctccac caagggccca      360

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      420

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      480

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      540

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      600

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg tgacaaaact      660

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      720

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      780

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      840

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc      900

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      960

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1020

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1080

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1140

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1200

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1320

tctccgggta aatga                                                      1335


<210>  46
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  46
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtatcagcag      120

ctcccaggaa cggcccccaa actcctcatc tatggtaatg ataaccggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cggtccgagg atgaggctga ttattactgt gcagtatggg atgacagcct gaatggtgtg      300

gtattcggcg gaggaaccaa gctgacggtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atga            654


<210>  47
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  47
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagatcgg      300

gtagagatga accagtggct ggccgactgg ggccagggta cactggtcac cgtgagctca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa tga                                  1353


<210>  48
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  48
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtatcagcag      120

ctcccaggaa cggcccccaa actcctcatc tataggaata atcagcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cggtccgagg atgaggctga ttattactgt gcagcatggg atgacagcct gaatggttgg      300

gtgttcggcg gaggaaccaa gctgacggtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atga            654


<210>  49
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  49
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attagtggca gcggtgggta catacactat      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gacctatagc      300

agtggcctgc atgatgcttt tgatatctgg ggccagggta cactggtcac cgtgagctca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa tga                                  1353


<210>  50
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  50
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtatcagcag      120

ctcccaggaa cggcccccaa actcctcatc tatgacaata ataagcgacc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cggtccgagg atgaggctga ttattactgt gcagcatggg atgacagcct gaatggttgg      300

gtgttcggcg gaggaaccaa gctgacggtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atga            654


<210>  51
<211>  1359
<212>  DNA
<213>  Homo sapiens

<400>  51
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcaaa gcctatagca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt atcagtaaca cgggaggtag cacagacttc      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccatgt attactgtgc gagattggga      300

tatagtggct acgacgaccg tggtatggac gtctggggcc aaggtacact ggtcaccgtg      360

agctcagcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            1359


<210>  52
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  52
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tgtactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat ggtaacagca atcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgccag tcctatgaca gcagcctgag tggtcctgtg      300

gtattcggcg gaggaaccaa gctgacggtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atga            654


<210>  53
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Gly Asn Asp Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Trp 
            100                 105                 110         


Asp Asp Ser Leu Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  54
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Ser Trp Ser Ser Arg Asp Lys Gly Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Thr Asp Leu Ala Arg Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  55
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  55

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Thr Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  56
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Thr Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  57
<211>  124
<212>  PRT
<213>  Mus musculus

<400>  57

Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val 
1               5                   10                  15      


Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr 
            20                  25                  30          


Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys 
        35                  40                  45              


Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg 
    50                  55                  60                  


Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr 
65                  70                  75                  80  


Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln 
                85                  90                  95      


Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr 
            100                 105                 110         


Asp Ile Pro Phe Glu Cys Lys Lys Pro Val Gln Lys 
        115                 120                 


<210>  58
<211>  141
<212>  PRT
<213>  Mus musculus

<400>  58

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Val Gln Lys 
    130                 135                 140     


<210>  59
<211>  124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter p7.5K

<400>  59
ccacccactt tttatagtaa gtttttcacc cataaataat aaatacaata attaatttct       60

cgtaaaagta gaaaatatat tctaatttat tgcacggtaa ggaagtagaa tcataaagaa      120

cagt                                                                   124


<210>  60
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter pH5.R

<400>  60
tttattctat acttaaaaaa tgaaaataaa tacaaaggtt cttgagggtt gtgttaaatt       60

gaaagcgaga aataatcata aattatttca ttatcgcgat atccgttaag tttg            114


<210>  61
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter pSE/L

<400>  61
aaaaattgaa attttatttt ttttttttgg aatataaata                             40


<210>  62
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  62

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp 
            100                 105                 110         


Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile 
145                 150                 155                 160 


Thr Asp Phe Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly 
                165                 170                 175     


Thr Pro Val Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala 
        195                 200                 205             


Trp Glu Arg His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His 
    210                 215                 220                 


Thr Val Glu Lys Ser Leu Ser Arg Ala Asp Cys Ser 
225                 230                 235     


<210>  63
<211>  469
<212>  PRT
<213>  Mus musculus

<400>  63

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Arg Val Glu Met Asn Gln Trp Leu Ala Asp 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser 
145                 150                 155                 160 


Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly 
225                 230                 235                 240 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
            260                 265                 270         


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
    290                 295                 300                 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
305                 310                 315                 320 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
                325                 330                 335     


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
        355                 360                 365             


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
    370                 375                 380                 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
385                 390                 395                 400 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
                405                 410                 415     


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
            420                 425                 430         


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
        435                 440                 445             


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
    450                 455                 460                 


Arg Thr Pro Gly Lys 
465                 


