               SEQUENCE LISTING

<110> Bayer Pharma Aktiengesellschaft
      Bayer Aktiengesellschaft

<120> 5-Aryl-3,9-diazaspiro[5.5]undecan-2-one Compounds

<130> BHC 18 3 039 EP

<160> 3

<170> BiSSAP 1.3.6

<210> 1
<211> 6270
<212> DNA
<213> Artificial Sequence


<220> 
<223> Firefly luciferase reporter under control of a TEAD-promoter

<400> 1
ggcctaactg gccggtacct atcgataggc cagtgccaag ttgagacagg aatgtgtgga       60

atgactgcaa gcttgagaca ggaatgtgtg gaatgactgc aagcttgaga caggaatgtg      120

tggaatgact gcaagcttga gacaggaatg tgtggaatga ctgcaagctt gagacaggaa      180

tgtgtggaat gactgcaagc ttgagacagg aatgtgtgga atgactgcaa gcttgagaca      240

ggaatgtgtg gaatgactgc aagcttgaga caggaatgtg tggaatgact gcaagcttga      300

gacaaagatc tggcctcggc ggccaagctt agacactaga gggtatataa tggaagctcg      360

acttccagct tggcaatccg gtactgttgg taaagccacc atggaagatg ccaaaaacat      420

taagaagggc ccagcgccat tctacccact cgaagacggg accgccggcg agcagctgca      480

caaagccatg aagcgctacg ccctggtgcc cggcaccatc gcctttaccg acgcacatat      540

cgaggtggac attacctacg ccgagtactt cgagatgagc gttcggctgg cagaagctat      600

gaagcgctat gggctgaata caaaccatcg gatcgtggtg tgcagcgaga atagcttgca      660

gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg gctgtggccc cagctaacga      720

catctacaac gagcgcgagc tgctgaacag catgggcatc agccagccca ccgtcgtatt      780

cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa aagaagctac cgatcataca      840

aaagatcatc atcatggata gcaagaccga ctaccagggc ttccaaagca tgtacacctt      900

cgtgacttcc catttgccac ccggcttcaa cgagtacgac ttcgtgcccg agagcttcga      960

ccgggacaaa accatcgccc tgatcatgaa cagtagtggc agtaccggat tgcccaaggg     1020

cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt catgcccgcg accccatctt     1080

cggcaaccag atcatccccg acaccgctat cctcagcgtg gtgccatttc accacggctt     1140

cggcatgttc accacgctgg gctacttgat ctgcggcttt cgggtcgtgc tcatgtaccg     1200

cttcgaggag gagctattct tgcgcagctt gcaagactat aagattcaat ctgccctgct     1260

ggtgcccaca ctatttagct tcttcgctaa gagcactctc atcgacaagt acgacctaag     1320

caacttgcac gagatcgcca gcggcggggc gccgctcagc aaggaggtag gtgaggccgt     1380

ggccaaacgc ttccacctac caggcatccg ccagggctac ggcctgacag aaacaaccag     1440

cgccattctg atcacccccg aaggggacga caagcctggc gcagtaggca aggtggtgcc     1500

cttcttcgag gctaaggtgg tggacttgga caccggtaag acactgggtg tgaaccagcg     1560

cggcgagctg tgcgtccgtg gccccatgat catgagcggc tacgttaaca accccgaggc     1620

tacaaacgct ctcatcgaca aggacggctg gctgcacagc ggcgacatcg cctactggga     1680

cgaggacgag cacttcttca tcgtggaccg gctgaagagc ctgatcaaat acaagggcta     1740

ccaggtagcc ccagccgaac tggagagcat cctgctgcaa caccccaaca tcttcgacgc     1800

cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg cccgccgcag tcgtcgtgct     1860

ggaacacggt aaaaccatga ccgagaagga gatcgtggac tatgtggcca gccaggttac     1920

aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac gaggtgccta aaggactgac     1980

cggcaagttg gacgcccgca agatccgcga gattctcatt aaggccaaga agggcggcaa     2040

gatcgccgtg aattctcacg gcttccctcc cgaggtggag gagcaggccg ccggcaccct     2100

gcccatgagc tgcgcccagg agagcggcat ggatagacac cctgctgctt gcgccagcgc     2160

caggatcaac gtctaaggcc gcgactctag agtcggggcg gccggccgct tcgagcagac     2220

atgataagat acattgatga gtttggacaa accacaacta gaatgcagtg aaaaaaatgc     2280

tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa     2340

caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga ggtgtgggag     2400

gttttttaaa gcaagtaaaa cctctacaaa tgtggtaaaa tcgataagga tccgtttgcg     2460

tattgggcgc tcttccgctg atctgcgcag caccatggcc tgaaataacc tctgaaagag     2520

gaacttggtt agctaccttc tgaggcggaa agaaccagct gtggaatgtg tgtcagttag     2580

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     2640

agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     2700

tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa     2760

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag     2820

aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc ttttttggag     2880

gcctaggctt ttgcaaaaag ctcgattctt ctgacactag cgccaccatg aagaagcccg     2940

aactcaccgc taccagcgtt gaaaaatttc tcatcgagaa gttcgacagt gtgagcgacc     3000

tgatgcagtt gtcggagggc gaagagagcc gagccttcag cttcgatgtc ggcggacgcg     3060

gctatgtact gcgggtgaat agctgcgctg atggcttcta caaagaccgc tacgtgtacc     3120

gccacttcgc cagcgctgca ctacccatcc ccgaagtgtt ggacatcggc gagttcagcg     3180

agagcctgac atactgcatc agtagacgcg cccaaggcgt tactctccaa gacctccccg     3240

aaacagagct gcctgctgtg ttacagcctg tcgccgaagc tatggatgct attgccgccg     3300

ccgacctcag tcaaaccagc ggcttcggcc cattcgggcc ccaaggcatc ggccagtaca     3360

caacctggcg ggatttcatt tgcgccattg ctgatcccca tgtctaccac tggcagaccg     3420

tgatggacga caccgtgtcc gccagcgtag ctcaagccct ggacgaactg atgctgtggg     3480

ccgaagactg tcccgaggtg cgccacctcg tccatgccga cttcggcagc aacaacgtcc     3540

tgaccgacaa cggccgcatc accgccgtaa tcgactggtc cgaagctatg ttcggggaca     3600

gtcagtacga ggtggccaac atcttcttct ggcggccctg gctggcttgc atggagcagc     3660

agactcgcta cttcgagcgc cggcatcccg agctggccgg cagccctcgt ctgcgagcct     3720

acatgctgcg catcggcctg gatcagctct accagagcct cgtggacggc aacttcgacg     3780

atgctgcctg ggctcaaggc cgctgcgatg ccatcgtccg cagcggggcc ggcaccgtcg     3840

gtcgcacaca aatcgctcgc cggagcgcag ccgtatggac cgacggctgc gtcgaggtgc     3900

tggccgacag cggcaaccgc cggcccagta cacgaccgcg cgctaaggag gtaggtcgag     3960

tttaaactct agaaccggtc atggccgcaa taaaatatct ttattttcat tacatctgtg     4020

tgttggtttt ttgtgtgttc gaactagatg ctgtcgaccg atgcccttga gagccttcaa     4080

cccagtcagc tccttccggt gggcgcgggg catgactatc gtcgccgcac ttatgactgt     4140

cttctttatc atgcaactcg taggacaggt gccggcagcg ctcttccgct tcctcgctca     4200

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     4260

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     4320

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     4380

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     4440

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     4500

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     4560

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     4620

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     4680

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     4740

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     4800

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     4860

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     4920

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     4980

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     5040

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     5100

atgagtaaac ttggtctgac agcggccgca aatgctaaac cactgcagtg gttaccagtg     5160

cttgatcagt gaggcaccga tctcagcgat ctgcctattt cgttcgtcca tagtggcctg     5220

actccccgtc gtgtagatca ctacgattcg tgagggctta ccatcaggcc ccagcgcagc     5280

aatgatgccg cgagagccgc gttcaccggc ccccgatttg tcagcaatga accagccagc     5340

agggagggcc gagcgaagaa gtggtcctgc tactttgtcc gcctccatcc agtctatgag     5400

ctgctgtcgt gatgctagag taagaagttc gccagtgagt agtttccgaa gagttgtggc     5460

cattgctact ggcatcgtgg tatcacgctc gtcgttcggt atggcttcgt tcaactctgg     5520

ttcccagcgg tcaagccggg tcacatgatc acccatatta tgaagaaatg cagtcagctc     5580

cttagggcct ccgatcgttg tcagaagtaa gttggccgcg gtgttgtcgc tcatggtaat     5640

ggcagcacta cacaattctc ttaccgtcat gccatccgta agatgctttt ccgtgaccgg     5700

cgagtactca accaagtcgt tttgtgagta gtgtatacgg cgaccaagct gctcttgccc     5760

ggcgtctata cgggacaaca ccgcgccaca tagcagtact ttgaaagtgc tcatcatcgg     5820

gaatcgttct tcggggcgga aagactcaag gatcttgccg ctattgagat ccagttcgat     5880

atagcccact cttgcaccca gttgatcttc agcatctttt actttcacca gcgtttcggg     5940

gtgtgcaaaa acaggcaagc aaaatgccgc aaagaaggga atgagtgcga cacgaaaatg     6000

ttggatgctc atactcgtcc tttttcaata ttattgaagc atttatcagg gttactagta     6060

cgtctctcaa ggataagtaa gtaatattaa ggtacgggag gtattggaca ggccgcaata     6120

aaatatcttt attttcatta catctgtgtg ttggtttttt gtgtgaatcg atagtactaa     6180

catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag gctgtcccca     6240

gtgcaagtgc aggtgccaga acatttctct                                      6270


<210> 2
<211> 278
<212> DNA
<213> Artificial Sequence


<220> 
<223> Firefly luciferase reporter under control of a TEAD-promoter
      (base pairs 27-304)

<400> 2
aggccagtgc caagttgaga caggaatgtg tggaatgact gcaagcttga gacaggaatg     60

tgtggaatga ctgcaagctt gagacaggaa tgtgtggaat gactgcaagc ttgagacagg    120

aatgtgtgga atgactgcaa gcttgagaca ggaatgtgtg gaatgactgc aagcttgaga    180

caggaatgtg tggaatgact gcaagcttga gacaggaatg tgtggaatga ctgcaagctt    240

gagacaggaa tgtgtggaat gactgcaagc ttgagaca                            278


<210> 3
<211> 5
<212> PRT
<213> Homo sapiens


<220> 
<223> Geranylgeranyl pyrophosphate (GGPP), recognition sequence

<400> 3
Gly Cys Val Leu Leu 
1               5   

