﻿                         SEQUENCE LISTING

<110>  The Council of the Queensland Institute of Medical Research
 
<120>  Biomarkers for cancer therapy

<130>  35531528

<140>  PCT/AU2019/050953
<141>  2019-09-06

<150>  2018903318
<151>  2018-09-06

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  2304
<212>  DNA
<213>  Homo sapiens

<400>  1
acgctgcgtg ccgctgctgg gttccgccac gcccgtcatg gcggcggccc cggccggctc       60

tggccccgcc cctcggtgac gcgtcgcgag tcacctgacc aggctgcggg ctgaggagat      120

acaagggaag tggctatcgc cagagtcgga ttcgccgccg cagcagccgc cgcccccggg      180

agccgccggg accctcgcgt cgtcgccgcc gccgccgccc agatccctgc accatgccgt      240

cggagaagac cttcaagcag cgccgcacct tcgaacaaag agtagaagat gtccgactta      300

ttcgagagca gcatccaacc aaaatcccgg tgataataga acgatacaag ggtgagaagc      360

agcttcctgt tctggataaa acaaagttcc ttgtacctga ccatgtcaac atgagtgagc      420

tcatcaagat aattagaagg cgcttacagc tcaatgctaa tcaggccttc ttcctgttgg      480

tgaacggaca cagcatggtc agcgtctcca caccaatctc agaggtgtat gagagtgaga      540

aagatgaaga tggattcctg tacatggtct atgcctccca ggagacgttc gggatgaaat      600

tgtcagtgta aaaccagaaa aaatgcagct cttctagaat tgtttaaacc cttaccaagg      660

aaaaaaaagg gatgttacca actgagatcg atcagttcat ccaatcacag atcatgaaac      720

agtagtgttc ccacctagga gtgttaggaa gttgtgtttg tgtttcaagc agaaaaactg      780

agctccaagt gagcacattc agctttggaa actatattat ttaatgtagg ctagcttgtt      840

ttcaaatttt aaaagtttaa aaataaaata ctttgcattc taagttgcca ataaaataga      900

ccttcaagtt attttaatgc tcttttctca ctaataggaa cttgtaattc cagcagtaat      960

ttaaaggctt tcagagagac cctgagtctt ctcttcaggt tcacagaacc cgccgccttt     1020

ttgggtagaa gttttctact cagctagaga gatctcccta agaggatctt taggcctgag     1080

ttgtgaagcg caacccccgc aaaacgcatt tgccatcaca gttggcacaa acgcagggta     1140

aacgggctgt gtgagaaaac ggccctgact gtaaactgct gaaggtccct gactcctaag     1200

agaaccacac ccaaagtcct cactcttgca ggggtagaca tttctggttt ggtttgttct     1260

ctagatagtt acacacataa agacaccact caaaaggaaa cttgaataat ttataatttt     1320

gatcgagttt cttaaaagac cctggagaaa gagtggcatt tcttctgttt caggttttgt     1380

ctgagttcaa actagtgcct gtgttgttac ggaaagcagc agtgtaccag tgtcactctg     1440

gagtacagcg ggagaaacac aaaatagtat aactgaaaac attaacattc agacacactc     1500

ccttctgcct tccggcttaa agctgtggat gatccacgtt tttgtttttt taatgttaaa     1560

tgtgtaactc agtattactg aaaaggtacc cacattttga atagtagtta tcactcttag     1620

gtcagacagc catcagaatt ctcccacacc aagtgcatgt cagttgtgga gaaaacatag     1680

caaaaagagc cgtacgctct ttacagatac taatgtcaag agttaaacct cctcaggttc     1740

aacctgtgat aaaagactag tgcttcccag tacttgcatg gggttcacta tttatagttt     1800

tcttgggagt atcacaggaa aatcacaatt acaccacttt agaccctatg tgtagcaggt     1860

cacaacttac ccttgtgtgt ttagatgtgt atgaaatacc tgtatacgtt agtgaaagct     1920

gtttactgta acggggaaaa ccagattctt tgcatctggg ccctctactg attgttaaag     1980

gagttcctgt cacctgctcc ccccaccccc gcatgcgtct gtccacttgg ctaactttta     2040

atatgtgtat ttttacatta tgtatattct taactggact gtctcgttta gactgtatac     2100

atcatatctg acattattgt aactaccgtg tgatcagtaa gattcctgta agaaatactg     2160

ctttttaaga aaaaaaataa catgctgagg ggtgacctat atcccatgtg agtggtcact     2220

ttatttatag gatctttaaa acatttttaa tgaactaagt tgaataaagg cacaattaaa     2280

aactgtcaaa aaaaaaaaaa aaaa                                            2304


<210>  2
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ser Glu Lys Thr Phe Lys Gln Arg Arg Thr Phe Glu Gln Arg 
1               5                   10                  15      


Val Glu Asp Val Arg Leu Ile Arg Glu Gln His Pro Thr Lys Ile Pro 
            20                  25                  30          


Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 
        35                  40                  45              


Lys Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Ile 
    50                  55                  60                  


Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Ala Asn Gln Ala Phe Phe 
65                  70                  75                  80  


Leu Leu Val Asn Gly His Ser Met Val Ser Val Ser Thr Pro Ile Ser 
                85                  90                  95      


Glu Val Tyr Glu Ser Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 
            100                 105                 110         


Tyr Ala Ser Gln Glu Thr Phe Gly Met Lys Leu Ser Val 
        115                 120                 125 


<210>  3
<211>  4045
<212>  DNA
<213>  Homo sapiens

<400>  3
agagatgcgg ggtctaccga gagggagggg gttgatgcgg gcccggggga ggggtcgtgc       60

ggcccctccg ggcagccgag gccgcggaag gggggggccc cacagaggaa gaggtaggcc      120

ccggagccta ctctctcttc ccagggccca ggcatcctgg accccccaac tctctactgg      180

gctgaccagc cctcctgtcc cttgtctccc ctcccagggg gaggcccccg ctgagatggg      240

ggcgctgctg ctggagaagg aaaccagagg agccaccgag agagttcatg gctctttggg      300

ggacacccct cgtagtgaag aaaccctgcc caaggccacc cccgactccc tggagcctgc      360

tggcccctca tctccagcct ctgtcactgt cactgttggt gatgaggggg ctgacacccc      420

tgtaggggct acaccactca ttggggatga atctgagaat cttgagggag atggggacct      480

ccgtgggggc cggatcctgc tgggccatgc cacaaagtca ttcccctctt cccccagcaa      540

ggggggttcc tgtcctagcc gggccaagat gtcaatgaca ggggcgggaa aatcacctcc      600

atctgtccag agtttggcta tgaggctact gagtatgcca ggagcccagg gagctgcagc      660

agcagggtct gaaccccctc cagccaccac gagcccagag ggacagccca aggtccaccg      720

agcccgcaaa accatgtcca aaccaggaaa tggacagccc ccggtccctg agaagcggcc      780

ccctgaaata cagcatttcc gcatgagtga tgatgtccac tcactgggaa aggtgacctc      840

agatctggcc aaaaggagga agctgaactc aggaggtggc ctgtcagagg agttaggttc      900

tgcccggcgt tcaggagaag tgaccctgac gaaaggggac cccgggtccc tggaggagtg      960

ggagacggtg gtgggtgatg acttcagtct ctactatgat tcctactctg tggatgagcg     1020

cgtggactcc gacagcaagt ctgaagttga agctctaact gaacaactaa gtgaagagga     1080

ggaggaggaa gaggaggaag aagaagaaga ggaagaggag gaggaagagg aagaagaaga     1140

ggaagatgag gagtcaggga atcagtcaga taggagtggt tccagtggcc ggcgcaaggc     1200

caagaagaaa tggcgaaaag acagcccatg ggtgaagccg tctcggaaac ggcgcaagcg     1260

ggagcctccg cgggccaagg agccacgagg ggtgtccaat gacacatctt cgctggagac     1320

agagcgaggg tttgaggagt tgcccctgtg cagctgccgc atggaggcac ccaagattga     1380

ccgcatcagc gagagggcgg ggcacaagtg catggccact gagagtgtgg acggagagct     1440

gtcaggctgc aatgccgcca tcctcaagcg ggagaccatg aggccatcca gccgtgtggc     1500

cctgatggtg ctctgtgaga cccaccgcgc ccgcatggtc aaacaccact gctgcccggg     1560

ctgcggctac ttctgcacgg cgggcacctt cctggagtgc caccctgact tccgtgtggc     1620

ccaccgcttc cacaaggcct gtgtgtctca gctgaatggg atggtcttct gtccccactg     1680

tggggaggat gcttctgaag ctcaagaggt gaccatcccc cggggtgacg gggtgacccc     1740

accggccggc actgcagctc ctgcaccccc acccctgtcc caggatgtcc ccgggagagc     1800

agacacttct cagcccagtg cccggatgcg agggcatggg gaaccccggc gcccgccctg     1860

cgatcccctg gctgacacca ttgacagctc agggccctcc ctgaccctgc ccaatggggg     1920

ctgcctttca gccgtggggc tgccactggg gccaggccgg gaggccctgg aaaaggccct     1980

ggtcatccag gagtcagaga ggcggaagaa gctccgtttc caccctcggc agttgtacct     2040

gtccgtgaag cagggcgagc tgcagaaggt gatcctgatg ctgttggaca acctggaccc     2100

caacttccag agcgaccagc agagcaagcg cacgcccctg catgcagccg cccagaaggg     2160

ctccgtggag atctgccatg tgctgctgca ggctggagcc aacataaatg cagtggacaa     2220

acagcagcgg acgccactga tggaggccgt ggtgaacaac cacctggagg tagcccgtta     2280

catggtgcag cgtggtggct gtgtctatag caaggaggag gacggttcca cctgcctcca     2340

ccacgcagcc aaaatcggga acttggagat ggtcagcctg ctgctgagca caggacaggt     2400

ggacgtcaac gcccaggaca gtggggggtg gacgcccatc atctgggctg cagagcacaa     2460

gcacatcgag gtgatccgca tgctactgac gcggggcgcc gacgtcaccc tcactgacaa     2520

cgaggagaac atctgcctgc actgggcctc cttcacgggc agcgccgcca tcgccgaagt     2580

ccttctgaat gcgcgctgtg acctccatgc tgtcaactac catggggaca cccccctgca     2640

catcgcagct cgggagagct accatgactg cgtgctgtta ttcctgtcac gtggggccaa     2700

ccctgagctg cggaacaaag agggggacac agcatgggac ctgactcccg agcgctccga     2760

cgtgtggttt gcgcttcaac tcaaccgcaa gctccgactt ggggtgggaa atcgggccat     2820

ccgcacagag aagatcatct gccgggacgt ggctcggggc tatgagaacg tgcccattcc     2880

ctgtgtcaac ggtgtggatg gggagccctg ccctgaggat tacaagtaca tctcagagaa     2940

ctgcgagacg tccaccatga acatcgatcg caacatcacc cacctgcagc actgcacgtg     3000

tgtggacgac tgctctagct ccaactgcct gtgcggccag ctcagcatcc ggtgctggta     3060

tgacaaggat gggcgattgc tccaggaatt taacaagatt gagcctccgc tgattttcga     3120

gtgtaaccag gcgtgctcat gctggagaaa ctgcaagaac cgggtcgtac agagtggcat     3180

caaggtgcgg ctacagctct accgaacagc caagatgggc tggggggtcc gcgccctgca     3240

gaccatccca caggggacct tcatctgcga gtatgtcggg gagctgatct ctgatgctga     3300

ggctgatgtg agagaggatg attcttacct cttcgactta gacaacaagg atggagaggt     3360

gtactgcata gatgcccgtt actatggcaa catcagccgc ttcatcaacc acctgtgtga     3420

ccccaacatc attcccgtcc gggtcttcat gctgcaccaa gacctgcgat ttccacgcat     3480

cgccttcttc agttcccgag acatccggac tggggaggag ctagggtttg actatggcga     3540

ccgcttctgg gacatcaaaa gcaaatattt cacctgccaa tgtggctctg agaagtgcaa     3600

gcactcagcc gaagccattg ccctggagca gagccgtctg gcccgcctgg acccacaccc     3660

tgagctgctg cccgagctcg gctccctgcc ccctgtcaac acatgagaac ggaccacacc     3720

ctctctcccc agcatggatg gccacagctc agccgcctcc tctgccacca gctgctcgca     3780

gcccatgcct gggggtgctg ccatcttctc tccccaccac cctttcacac attcctgacc     3840

agagatccca gccaggccct ggaggtctga cagcccctcc ctcccagagc tggttcctcc     3900

ctgggagggc aacttcaggg ctggccaccc cccgtgttcc ccatcctcag ttgaagtttg     3960

atgaattgaa gtcgggcctc tatgccaact ggttcctttt gttctcaata aatgttgggt     4020

ttggtaataa aaaaaaaaaa aaaaa                                           4045


<210>  4
<211>  1233
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Gly Leu Pro Arg Gly Arg Gly Leu Met Arg Ala Arg Gly Arg 
1               5                   10                  15      


Gly Arg Ala Ala Pro Pro Gly Ser Arg Gly Arg Gly Arg Gly Gly Pro 
            20                  25                  30          


His Arg Gly Arg Gly Arg Pro Arg Ser Leu Leu Ser Leu Pro Arg Ala 
        35                  40                  45              


Gln Ala Ser Trp Thr Pro Gln Leu Ser Thr Gly Leu Thr Ser Pro Pro 
    50                  55                  60                  


Val Pro Cys Leu Pro Ser Gln Gly Glu Ala Pro Ala Glu Met Gly Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Glu Thr Arg Gly Ala Thr Glu Arg Val His Gly 
                85                  90                  95      


Ser Leu Gly Asp Thr Pro Arg Ser Glu Glu Thr Leu Pro Lys Ala Thr 
            100                 105                 110         


Pro Asp Ser Leu Glu Pro Ala Gly Pro Ser Ser Pro Ala Ser Val Thr 
        115                 120                 125             


Val Thr Val Gly Asp Glu Gly Ala Asp Thr Pro Val Gly Ala Thr Pro 
    130                 135                 140                 


Leu Ile Gly Asp Glu Ser Glu Asn Leu Glu Gly Asp Gly Asp Leu Arg 
145                 150                 155                 160 


Gly Gly Arg Ile Leu Leu Gly His Ala Thr Lys Ser Phe Pro Ser Ser 
                165                 170                 175     


Pro Ser Lys Gly Gly Ser Cys Pro Ser Arg Ala Lys Met Ser Met Thr 
            180                 185                 190         


Gly Ala Gly Lys Ser Pro Pro Ser Val Gln Ser Leu Ala Met Arg Leu 
        195                 200                 205             


Leu Ser Met Pro Gly Ala Gln Gly Ala Ala Ala Ala Gly Ser Glu Pro 
    210                 215                 220                 


Pro Pro Ala Thr Thr Ser Pro Glu Gly Gln Pro Lys Val His Arg Ala 
225                 230                 235                 240 


Arg Lys Thr Met Ser Lys Pro Gly Asn Gly Gln Pro Pro Val Pro Glu 
                245                 250                 255     


Lys Arg Pro Pro Glu Ile Gln His Phe Arg Met Ser Asp Asp Val His 
            260                 265                 270         


Ser Leu Gly Lys Val Thr Ser Asp Leu Ala Lys Arg Arg Lys Leu Asn 
        275                 280                 285             


Ser Gly Gly Gly Leu Ser Glu Glu Leu Gly Ser Ala Arg Arg Ser Gly 
    290                 295                 300                 


Glu Val Thr Leu Thr Lys Gly Asp Pro Gly Ser Leu Glu Glu Trp Glu 
305                 310                 315                 320 


Thr Val Val Gly Asp Asp Phe Ser Leu Tyr Tyr Asp Ser Tyr Ser Val 
                325                 330                 335     


Asp Glu Arg Val Asp Ser Asp Ser Lys Ser Glu Val Glu Ala Leu Thr 
            340                 345                 350         


Glu Gln Leu Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Ser 
    370                 375                 380                 


Gly Asn Gln Ser Asp Arg Ser Gly Ser Ser Gly Arg Arg Lys Ala Lys 
385                 390                 395                 400 


Lys Lys Trp Arg Lys Asp Ser Pro Trp Val Lys Pro Ser Arg Lys Arg 
                405                 410                 415     


Arg Lys Arg Glu Pro Pro Arg Ala Lys Glu Pro Arg Gly Val Ser Asn 
            420                 425                 430         


Asp Thr Ser Ser Leu Glu Thr Glu Arg Gly Phe Glu Glu Leu Pro Leu 
        435                 440                 445             


Cys Ser Cys Arg Met Glu Ala Pro Lys Ile Asp Arg Ile Ser Glu Arg 
    450                 455                 460                 


Ala Gly His Lys Cys Met Ala Thr Glu Ser Val Asp Gly Glu Leu Ser 
465                 470                 475                 480 


Gly Cys Asn Ala Ala Ile Leu Lys Arg Glu Thr Met Arg Pro Ser Ser 
                485                 490                 495     


Arg Val Ala Leu Met Val Leu Cys Glu Thr His Arg Ala Arg Met Val 
            500                 505                 510         


Lys His His Cys Cys Pro Gly Cys Gly Tyr Phe Cys Thr Ala Gly Thr 
        515                 520                 525             


Phe Leu Glu Cys His Pro Asp Phe Arg Val Ala His Arg Phe His Lys 
    530                 535                 540                 


Ala Cys Val Ser Gln Leu Asn Gly Met Val Phe Cys Pro His Cys Gly 
545                 550                 555                 560 


Glu Asp Ala Ser Glu Ala Gln Glu Val Thr Ile Pro Arg Gly Asp Gly 
                565                 570                 575     


Val Thr Pro Pro Ala Gly Thr Ala Ala Pro Ala Pro Pro Pro Leu Ser 
            580                 585                 590         


Gln Asp Val Pro Gly Arg Ala Asp Thr Ser Gln Pro Ser Ala Arg Met 
        595                 600                 605             


Arg Gly His Gly Glu Pro Arg Arg Pro Pro Cys Asp Pro Leu Ala Asp 
    610                 615                 620                 


Thr Ile Asp Ser Ser Gly Pro Ser Leu Thr Leu Pro Asn Gly Gly Cys 
625                 630                 635                 640 


Leu Ser Ala Val Gly Leu Pro Leu Gly Pro Gly Arg Glu Ala Leu Glu 
                645                 650                 655     


Lys Ala Leu Val Ile Gln Glu Ser Glu Arg Arg Lys Lys Leu Arg Phe 
            660                 665                 670         


His Pro Arg Gln Leu Tyr Leu Ser Val Lys Gln Gly Glu Leu Gln Lys 
        675                 680                 685             


Val Ile Leu Met Leu Leu Asp Asn Leu Asp Pro Asn Phe Gln Ser Asp 
    690                 695                 700                 


Gln Gln Ser Lys Arg Thr Pro Leu His Ala Ala Ala Gln Lys Gly Ser 
705                 710                 715                 720 


Val Glu Ile Cys His Val Leu Leu Gln Ala Gly Ala Asn Ile Asn Ala 
                725                 730                 735     


Val Asp Lys Gln Gln Arg Thr Pro Leu Met Glu Ala Val Val Asn Asn 
            740                 745                 750         


His Leu Glu Val Ala Arg Tyr Met Val Gln Arg Gly Gly Cys Val Tyr 
        755                 760                 765             


Ser Lys Glu Glu Asp Gly Ser Thr Cys Leu His His Ala Ala Lys Ile 
    770                 775                 780                 


Gly Asn Leu Glu Met Val Ser Leu Leu Leu Ser Thr Gly Gln Val Asp 
785                 790                 795                 800 


Val Asn Ala Gln Asp Ser Gly Gly Trp Thr Pro Ile Ile Trp Ala Ala 
                805                 810                 815     


Glu His Lys His Ile Glu Val Ile Arg Met Leu Leu Thr Arg Gly Ala 
            820                 825                 830         


Asp Val Thr Leu Thr Asp Asn Glu Glu Asn Ile Cys Leu His Trp Ala 
        835                 840                 845             


Ser Phe Thr Gly Ser Ala Ala Ile Ala Glu Val Leu Leu Asn Ala Arg 
    850                 855                 860                 


Cys Asp Leu His Ala Val Asn Tyr His Gly Asp Thr Pro Leu His Ile 
865                 870                 875                 880 


Ala Ala Arg Glu Ser Tyr His Asp Cys Val Leu Leu Phe Leu Ser Arg 
                885                 890                 895     


Gly Ala Asn Pro Glu Leu Arg Asn Lys Glu Gly Asp Thr Ala Trp Asp 
            900                 905                 910         


Leu Thr Pro Glu Arg Ser Asp Val Trp Phe Ala Leu Gln Leu Asn Arg 
        915                 920                 925             


Lys Leu Arg Leu Gly Val Gly Asn Arg Ala Ile Arg Thr Glu Lys Ile 
    930                 935                 940                 


Ile Cys Arg Asp Val Ala Arg Gly Tyr Glu Asn Val Pro Ile Pro Cys 
945                 950                 955                 960 


Val Asn Gly Val Asp Gly Glu Pro Cys Pro Glu Asp Tyr Lys Tyr Ile 
                965                 970                 975     


Ser Glu Asn Cys Glu Thr Ser Thr Met Asn Ile Asp Arg Asn Ile Thr 
            980                 985                 990         


His Leu Gln His Cys Thr Cys Val  Asp Asp Cys Ser Ser  Ser Asn Cys 
        995                 1000                 1005             


Leu Cys  Gly Gln Leu Ser Ile  Arg Cys Trp Tyr Asp  Lys Asp Gly 
    1010                 1015                 1020             


Arg Leu  Leu Gln Glu Phe Asn  Lys Ile Glu Pro Pro  Leu Ile Phe 
    1025                 1030                 1035             


Glu Cys  Asn Gln Ala Cys Ser  Cys Trp Arg Asn Cys  Lys Asn Arg 
    1040                 1045                 1050             


Val Val  Gln Ser Gly Ile Lys  Val Arg Leu Gln Leu  Tyr Arg Thr 
    1055                 1060                 1065             


Ala Lys  Met Gly Trp Gly Val  Arg Ala Leu Gln Thr  Ile Pro Gln 
    1070                 1075                 1080             


Gly Thr  Phe Ile Cys Glu Tyr  Val Gly Glu Leu Ile  Ser Asp Ala 
    1085                 1090                 1095             


Glu Ala  Asp Val Arg Glu Asp  Asp Ser Tyr Leu Phe  Asp Leu Asp 
    1100                 1105                 1110             


Asn Lys  Asp Gly Glu Val Tyr  Cys Ile Asp Ala Arg  Tyr Tyr Gly 
    1115                 1120                 1125             


Asn Ile  Ser Arg Phe Ile Asn  His Leu Cys Asp Pro  Asn Ile Ile 
    1130                 1135                 1140             


Pro Val  Arg Val Phe Met Leu  His Gln Asp Leu Arg  Phe Pro Arg 
    1145                 1150                 1155             


Ile Ala  Phe Phe Ser Ser Arg  Asp Ile Arg Thr Gly  Glu Glu Leu 
    1160                 1165                 1170             


Gly Phe  Asp Tyr Gly Asp Arg  Phe Trp Asp Ile Lys  Ser Lys Tyr 
    1175                 1180                 1185             


Phe Thr  Cys Gln Cys Gly Ser  Glu Lys Cys Lys His  Ser Ala Glu 
    1190                 1195                 1200             


Ala Ile  Ala Leu Glu Gln Ser  Arg Leu Ala Arg Leu  Asp Pro His 
    1205                 1210                 1215             


Pro Glu  Leu Leu Pro Glu Leu  Gly Ser Leu Pro Pro  Val Asn Thr 
    1220                 1225                 1230             


<210>  5
<211>  4002
<212>  DNA
<213>  Homo sapiens

<400>  5
gcgccggctc ggcccccagc gcaagcggcg atggcggcgg cggcgggagc tgcagcggcg       60

gcggccgccg agggggaggc ccccgctgag atgggggcgc tgctgctgga gaaggaaacc      120

agaggagcca ccgagagagt tcatggctct ttgggggaca cccctcgtag tgaagaaacc      180

ctgcccaagg ccacccccga ctccctggag cctgctggcc cctcatctcc agcctctgtc      240

actgtcactg ttggtgatga gggggctgac acccctgtag gggctacacc actcattggg      300

gatgaatctg agaatcttga gggagatggg gacctccgtg ggggccggat cctgctgggc      360

catgccacaa agtcattccc ctcttccccc agcaaggggg gttcctgtcc tagccgggcc      420

aagatgtcaa tgacaggggc gggaaaatca cctccatctg tccagagttt ggctatgagg      480

ctactgagta tgccaggagc ccagggagct gcagcagcag ggtctgaacc ccctccagcc      540

accacgagcc cagagggaca gcccaaggtc caccgagccc gcaaaaccat gtccaaacca      600

ggaaatggac agcccccggt ccctgagaag cggccccctg aaatacagca tttccgcatg      660

agtgatgatg tccactcact gggaaaggtg acctcagatc tggccaaaag gaggaagctg      720

aactcaggag gtggcctgtc agaggagtta ggttctgccc ggcgttcagg agaagtgacc      780

ctgacgaaag gggaccccgg gtccctggag gagtgggaga cggtggtggg tgatgacttc      840

agtctctact atgattccta ctctgtggat gagcgcgtgg actccgacag caagtctgaa      900

gttgaagctc taactgaaca actaagtgaa gaggaggagg aggaagagga ggaagaagaa      960

gaagaggaag aggaggagga agaggaagaa gaagaggaag atgaggagtc agggaatcag     1020

tcagatagga gtggttccag tggccggcgc aaggccaaga agaaatggcg aaaagacagc     1080

ccatgggtga agccgtctcg gaaacggcgc aagcgggagc ctccgcgggc caaggagcca     1140

cgaggagtga atggtgtggg ctcctcaggc cccagtgagt acatggaggt ccctctgggg     1200

tccctggagc tgcccagcga ggggaccctc tcccccaacc acgctggggt gtccaatgac     1260

acatcttcgc tggagacaga gcgagggttt gaggagttgc ccctgtgcag ctgccgcatg     1320

gaggcaccca agattgaccg catcagcgag agggcggggc acaagtgcat ggccactgag     1380

agtgtggacg gagagctgtc aggctgcaat gccgccatcc tcaagcggga gaccatgagg     1440

ccatccagcc gtgtggccct gatggtgctc tgtgagaccc accgcgcccg catggtcaaa     1500

caccactgct gcccgggctg cggctacttc tgcacggcgg gcaccttcct ggagtgccac     1560

cctgacttcc gtgtggccca ccgcttccac aaggcctgtg tgtctcagct gaatgggatg     1620

gtcttctgtc cccactgtgg ggaggatgct tctgaagctc aagaggtgac catcccccgg     1680

ggtgacgggg tgaccccacc ggccggcact gcagctcctg cacccccacc cctgtcccag     1740

gatgtccccg ggagagcaga cacttctcag cccagtgccc ggatgcgagg gcatggggaa     1800

ccccggcgcc cgccctgcga tcccctggct gacaccattg acagctcagg gccctccctg     1860

accctgccca atgggggctg cctttcagcc gtggggctgc cactggggcc aggccgggag     1920

gccctggaaa aggccctggt catccaggag tcagagaggc ggaagaagct ccgtttccac     1980

cctcggcagt tgtacctgtc cgtgaagcag ggcgagctgc agaaggtgat cctgatgctg     2040

ttggacaacc tggaccccaa cttccagagc gaccagcaga gcaagcgcac gcccctgcat     2100

gcagccgccc agaagggctc cgtggagatc tgccatgtgc tgctgcaggc tggagccaac     2160

ataaatgcag tggacaaaca gcagcggacg ccactgatgg aggccgtggt gaacaaccac     2220

ctggaggtag cccgttacat ggtgcagcgt ggtggctgtg tctatagcaa ggaggaggac     2280

ggttccacct gcctccacca cgcagccaaa atcgggaact tggagatggt cagcctgctg     2340

ctgagcacag gacaggtgga cgtcaacgcc caggacagtg gggggtggac gcccatcatc     2400

tgggctgcag agcacaagca catcgaggtg atccgcatgc tactgacgcg gggcgccgac     2460

gtcaccctca ctgacaacga ggagaacatc tgcctgcact gggcctcctt cacgggcagc     2520

gccgccatcg ccgaagtcct tctgaatgcg cgctgtgacc tccatgctgt caactaccat     2580

ggggacaccc ccctgcacat cgcagctcgg gagagctacc atgactgcgt gctgttattc     2640

ctgtcacgtg gggccaaccc tgagctgcgg aacaaagagg gggacacagc atgggacctg     2700

actcccgagc gctccgacgt gtggtttgcg cttcaactca accgcaagct ccgacttggg     2760

gtgggaaatc gggccatccg cacagagaag atcatctgcc gggacgtggc tcggggctat     2820

gagaacgtgc ccattccctg tgtcaacggt gtggatgggg agccctgccc tgaggattac     2880

aagtacatct cagagaactg cgagacgtcc accatgaaca tcgatcgcaa catcacccac     2940

ctgcagcact gcacgtgtgt ggacgactgc tctagctcca actgcctgtg cggccagctc     3000

agcatccggt gctggtatga caaggatggg cgattgctcc aggaatttaa caagattgag     3060

cctccgctga ttttcgagtg taaccaggcg tgctcatgct ggagaaactg caagaaccgg     3120

gtcgtacaga gtggcatcaa ggtgcggcta cagctctacc gaacagccaa gatgggctgg     3180

ggggtccgcg ccctgcagac catcccacag gggaccttca tctgcgagta tgtcggggag     3240

ctgatctctg atgctgaggc tgatgtgaga gaggatgatt cttacctctt cgacttagac     3300

aacaaggatg gagaggtgta ctgcatagat gcccgttact atggcaacat cagccgcttc     3360

atcaaccacc tgtgtgaccc caacatcatt cccgtccggg tcttcatgct gcaccaagac     3420

ctgcgatttc cacgcatcgc cttcttcagt tcccgagaca tccggactgg ggaggagcta     3480

gggtttgact atggcgaccg cttctgggac atcaaaagca aatatttcac ctgccaatgt     3540

ggctctgaga agtgcaagca ctcagccgaa gccattgccc tggagcagag ccgtctggcc     3600

cgcctggacc cacaccctga gctgctgccc gagctcggct ccctgccccc tgtcaacaca     3660

tgagaacgga ccacaccctc tctccccagc atggatggcc acagctcagc cgcctcctct     3720

gccaccagct gctcgcagcc catgcctggg ggtgctgcca tcttctctcc ccaccaccct     3780

ttcacacatt cctgaccaga gatcccagcc aggccctgga ggtctgacag cccctccctc     3840

ccagagctgg ttcctccctg ggagggcaac ttcagggctg gccacccccc gtgttcccca     3900

tcctcagttg aagtttgatg aattgaagtc gggcctctat gccaactggt tccttttgtt     3960

ctcaataaat gttgggtttg gtaataaaaa aaaaaaaaaa aa                        4002


<210>  6
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Ala Ala Gly Ala Ala Ala Ala Ala Ala Ala Glu Gly Glu 
1               5                   10                  15      


Ala Pro Ala Glu Met Gly Ala Leu Leu Leu Glu Lys Glu Thr Arg Gly 
            20                  25                  30          


Ala Thr Glu Arg Val His Gly Ser Leu Gly Asp Thr Pro Arg Ser Glu 
        35                  40                  45              


Glu Thr Leu Pro Lys Ala Thr Pro Asp Ser Leu Glu Pro Ala Gly Pro 
    50                  55                  60                  


Ser Ser Pro Ala Ser Val Thr Val Thr Val Gly Asp Glu Gly Ala Asp 
65                  70                  75                  80  


Thr Pro Val Gly Ala Thr Pro Leu Ile Gly Asp Glu Ser Glu Asn Leu 
                85                  90                  95      


Glu Gly Asp Gly Asp Leu Arg Gly Gly Arg Ile Leu Leu Gly His Ala 
            100                 105                 110         


Thr Lys Ser Phe Pro Ser Ser Pro Ser Lys Gly Gly Ser Cys Pro Ser 
        115                 120                 125             


Arg Ala Lys Met Ser Met Thr Gly Ala Gly Lys Ser Pro Pro Ser Val 
    130                 135                 140                 


Gln Ser Leu Ala Met Arg Leu Leu Ser Met Pro Gly Ala Gln Gly Ala 
145                 150                 155                 160 


Ala Ala Ala Gly Ser Glu Pro Pro Pro Ala Thr Thr Ser Pro Glu Gly 
                165                 170                 175     


Gln Pro Lys Val His Arg Ala Arg Lys Thr Met Ser Lys Pro Gly Asn 
            180                 185                 190         


Gly Gln Pro Pro Val Pro Glu Lys Arg Pro Pro Glu Ile Gln His Phe 
        195                 200                 205             


Arg Met Ser Asp Asp Val His Ser Leu Gly Lys Val Thr Ser Asp Leu 
    210                 215                 220                 


Ala Lys Arg Arg Lys Leu Asn Ser Gly Gly Gly Leu Ser Glu Glu Leu 
225                 230                 235                 240 


Gly Ser Ala Arg Arg Ser Gly Glu Val Thr Leu Thr Lys Gly Asp Pro 
                245                 250                 255     


Gly Ser Leu Glu Glu Trp Glu Thr Val Val Gly Asp Asp Phe Ser Leu 
            260                 265                 270         


Tyr Tyr Asp Ser Tyr Ser Val Asp Glu Arg Val Asp Ser Asp Ser Lys 
        275                 280                 285             


Ser Glu Val Glu Ala Leu Thr Glu Gln Leu Ser Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Glu Asp Glu Glu Ser Gly Asn Gln Ser Asp Arg Ser Gly Ser 
                325                 330                 335     


Ser Gly Arg Arg Lys Ala Lys Lys Lys Trp Arg Lys Asp Ser Pro Trp 
            340                 345                 350         


Val Lys Pro Ser Arg Lys Arg Arg Lys Arg Glu Pro Pro Arg Ala Lys 
        355                 360                 365             


Glu Pro Arg Gly Val Asn Gly Val Gly Ser Ser Gly Pro Ser Glu Tyr 
    370                 375                 380                 


Met Glu Val Pro Leu Gly Ser Leu Glu Leu Pro Ser Glu Gly Thr Leu 
385                 390                 395                 400 


Ser Pro Asn His Ala Gly Val Ser Asn Asp Thr Ser Ser Leu Glu Thr 
                405                 410                 415     


Glu Arg Gly Phe Glu Glu Leu Pro Leu Cys Ser Cys Arg Met Glu Ala 
            420                 425                 430         


Pro Lys Ile Asp Arg Ile Ser Glu Arg Ala Gly His Lys Cys Met Ala 
        435                 440                 445             


Thr Glu Ser Val Asp Gly Glu Leu Ser Gly Cys Asn Ala Ala Ile Leu 
    450                 455                 460                 


Lys Arg Glu Thr Met Arg Pro Ser Ser Arg Val Ala Leu Met Val Leu 
465                 470                 475                 480 


Cys Glu Thr His Arg Ala Arg Met Val Lys His His Cys Cys Pro Gly 
                485                 490                 495     


Cys Gly Tyr Phe Cys Thr Ala Gly Thr Phe Leu Glu Cys His Pro Asp 
            500                 505                 510         


Phe Arg Val Ala His Arg Phe His Lys Ala Cys Val Ser Gln Leu Asn 
        515                 520                 525             


Gly Met Val Phe Cys Pro His Cys Gly Glu Asp Ala Ser Glu Ala Gln 
    530                 535                 540                 


Glu Val Thr Ile Pro Arg Gly Asp Gly Val Thr Pro Pro Ala Gly Thr 
545                 550                 555                 560 


Ala Ala Pro Ala Pro Pro Pro Leu Ser Gln Asp Val Pro Gly Arg Ala 
                565                 570                 575     


Asp Thr Ser Gln Pro Ser Ala Arg Met Arg Gly His Gly Glu Pro Arg 
            580                 585                 590         


Arg Pro Pro Cys Asp Pro Leu Ala Asp Thr Ile Asp Ser Ser Gly Pro 
        595                 600                 605             


Ser Leu Thr Leu Pro Asn Gly Gly Cys Leu Ser Ala Val Gly Leu Pro 
    610                 615                 620                 


Leu Gly Pro Gly Arg Glu Ala Leu Glu Lys Ala Leu Val Ile Gln Glu 
625                 630                 635                 640 


Ser Glu Arg Arg Lys Lys Leu Arg Phe His Pro Arg Gln Leu Tyr Leu 
                645                 650                 655     


Ser Val Lys Gln Gly Glu Leu Gln Lys Val Ile Leu Met Leu Leu Asp 
            660                 665                 670         


Asn Leu Asp Pro Asn Phe Gln Ser Asp Gln Gln Ser Lys Arg Thr Pro 
        675                 680                 685             


Leu His Ala Ala Ala Gln Lys Gly Ser Val Glu Ile Cys His Val Leu 
    690                 695                 700                 


Leu Gln Ala Gly Ala Asn Ile Asn Ala Val Asp Lys Gln Gln Arg Thr 
705                 710                 715                 720 


Pro Leu Met Glu Ala Val Val Asn Asn His Leu Glu Val Ala Arg Tyr 
                725                 730                 735     


Met Val Gln Arg Gly Gly Cys Val Tyr Ser Lys Glu Glu Asp Gly Ser 
            740                 745                 750         


Thr Cys Leu His His Ala Ala Lys Ile Gly Asn Leu Glu Met Val Ser 
        755                 760                 765             


Leu Leu Leu Ser Thr Gly Gln Val Asp Val Asn Ala Gln Asp Ser Gly 
    770                 775                 780                 


Gly Trp Thr Pro Ile Ile Trp Ala Ala Glu His Lys His Ile Glu Val 
785                 790                 795                 800 


Ile Arg Met Leu Leu Thr Arg Gly Ala Asp Val Thr Leu Thr Asp Asn 
                805                 810                 815     


Glu Glu Asn Ile Cys Leu His Trp Ala Ser Phe Thr Gly Ser Ala Ala 
            820                 825                 830         


Ile Ala Glu Val Leu Leu Asn Ala Arg Cys Asp Leu His Ala Val Asn 
        835                 840                 845             


Tyr His Gly Asp Thr Pro Leu His Ile Ala Ala Arg Glu Ser Tyr His 
    850                 855                 860                 


Asp Cys Val Leu Leu Phe Leu Ser Arg Gly Ala Asn Pro Glu Leu Arg 
865                 870                 875                 880 


Asn Lys Glu Gly Asp Thr Ala Trp Asp Leu Thr Pro Glu Arg Ser Asp 
                885                 890                 895     


Val Trp Phe Ala Leu Gln Leu Asn Arg Lys Leu Arg Leu Gly Val Gly 
            900                 905                 910         


Asn Arg Ala Ile Arg Thr Glu Lys Ile Ile Cys Arg Asp Val Ala Arg 
        915                 920                 925             


Gly Tyr Glu Asn Val Pro Ile Pro Cys Val Asn Gly Val Asp Gly Glu 
    930                 935                 940                 


Pro Cys Pro Glu Asp Tyr Lys Tyr Ile Ser Glu Asn Cys Glu Thr Ser 
945                 950                 955                 960 


Thr Met Asn Ile Asp Arg Asn Ile Thr His Leu Gln His Cys Thr Cys 
                965                 970                 975     


Val Asp Asp Cys Ser Ser Ser Asn Cys Leu Cys Gly Gln Leu Ser Ile 
            980                 985                 990         


Arg Cys Trp Tyr Asp Lys Asp Gly  Arg Leu Leu Gln Glu  Phe Asn Lys 
        995                 1000                 1005             


Ile Glu  Pro Pro Leu Ile Phe  Glu Cys Asn Gln Ala  Cys Ser Cys 
    1010                 1015                 1020             


Trp Arg  Asn Cys Lys Asn Arg  Val Val Gln Ser Gly  Ile Lys Val 
    1025                 1030                 1035             


Arg Leu  Gln Leu Tyr Arg Thr  Ala Lys Met Gly Trp  Gly Val Arg 
    1040                 1045                 1050             


Ala Leu  Gln Thr Ile Pro Gln  Gly Thr Phe Ile Cys  Glu Tyr Val 
    1055                 1060                 1065             


Gly Glu  Leu Ile Ser Asp Ala  Glu Ala Asp Val Arg  Glu Asp Asp 
    1070                 1075                 1080             


Ser Tyr  Leu Phe Asp Leu Asp  Asn Lys Asp Gly Glu  Val Tyr Cys 
    1085                 1090                 1095             


Ile Asp  Ala Arg Tyr Tyr Gly  Asn Ile Ser Arg Phe  Ile Asn His 
    1100                 1105                 1110             


Leu Cys  Asp Pro Asn Ile Ile  Pro Val Arg Val Phe  Met Leu His 
    1115                 1120                 1125             


Gln Asp  Leu Arg Phe Pro Arg  Ile Ala Phe Phe Ser  Ser Arg Asp 
    1130                 1135                 1140             


Ile Arg  Thr Gly Glu Glu Leu  Gly Phe Asp Tyr Gly  Asp Arg Phe 
    1145                 1150                 1155             


Trp Asp  Ile Lys Ser Lys Tyr  Phe Thr Cys Gln Cys  Gly Ser Glu 
    1160                 1165                 1170             


Lys Cys  Lys His Ser Ala Glu  Ala Ile Ala Leu Glu  Gln Ser Arg 
    1175                 1180                 1185             


Leu Ala  Arg Leu Asp Pro His  Pro Glu Leu Leu Pro  Glu Leu Gly 
    1190                 1195                 1200             


Ser Leu  Pro Pro Val Asn Thr  
    1205                 1210 


<210>  7
<211>  3900
<212>  DNA
<213>  Homo sapiens

<400>  7
gcgccggctc ggcccccagc gcaagcggcg atggcggcgg cggcgggagc tgcagcggcg       60

gcggccgccg agggggaggc ccccgctgag atgggggcgc tgctgctgga gaaggaaacc      120

agaggagcca ccgagagagt tcatggctct ttgggggaca cccctcgtag tgaagaaacc      180

ctgcccaagg ccacccccga ctccctggag cctgctggcc cctcatctcc agcctctgtc      240

actgtcactg ttggtgatga gggggctgac acccctgtag gggctacacc actcattggg      300

gatgaatctg agaatcttga gggagatggg gacctccgtg ggggccggat cctgctgggc      360

catgccacaa agtcattccc ctcttccccc agcaaggggg gttcctgtcc tagccgggcc      420

aagatgtcaa tgacaggggc gggaaaatca cctccatctg tccagagttt ggctatgagg      480

ctactgagta tgccaggagc ccagggagct gcagcagcag ggtctgaacc ccctccagcc      540

accacgagcc cagagggaca gcccaaggtc caccgagccc gcaaaaccat gtccaaacca      600

ggaaatggac agcccccggt ccctgagaag cggccccctg aaatacagca tttccgcatg      660

agtgatgatg tccactcact gggaaaggtg acctcagatc tggccaaaag gaggaagctg      720

aactcaggag gtggcctgtc agaggagtta ggttctgccc ggcgttcagg agaagtgacc      780

ctgacgaaag gggaccccgg gtccctggag gagtgggaga cggtggtggg tgatgacttc      840

agtctctact atgattccta ctctgtggat gagcgcgtgg actccgacag caagtctgaa      900

gttgaagctc taactgaaca actaagtgaa gaggaggagg aggaagagga ggaagaagaa      960

gaagaggaag aggaggagga agaggaagaa gaagaggaag atgaggagtc agggaatcag     1020

tcagatagga gtggttccag tggccggcgc aaggccaaga agaaatggcg aaaagacagc     1080

ccatgggtga agccgtctcg gaaacggcgc aagcgggagc ctccgcgggc caaggagcca     1140

cgaggggtgt ccaatgacac atcttcgctg gagacagagc gagggtttga ggagttgccc     1200

ctgtgcagct gccgcatgga ggcacccaag attgaccgca tcagcgagag ggcggggcac     1260

aagtgcatgg ccactgagag tgtggacgga gagctgtcag gctgcaatgc cgccatcctc     1320

aagcgggaga ccatgaggcc atccagccgt gtggccctga tggtgctctg tgagacccac     1380

cgcgcccgca tggtcaaaca ccactgctgc ccgggctgcg gctacttctg cacggcgggc     1440

accttcctgg agtgccaccc tgacttccgt gtggcccacc gcttccacaa ggcctgtgtg     1500

tctcagctga atgggatggt cttctgtccc cactgtgggg aggatgcttc tgaagctcaa     1560

gaggtgacca tcccccgggg tgacggggtg accccaccgg ccggcactgc agctcctgca     1620

cccccacccc tgtcccagga tgtccccggg agagcagaca cttctcagcc cagtgcccgg     1680

atgcgagggc atggggaacc ccggcgcccg ccctgcgatc ccctggctga caccattgac     1740

agctcagggc cctccctgac cctgcccaat gggggctgcc tttcagccgt ggggctgcca     1800

ctggggccag gccgggaggc cctggaaaag gccctggtca tccaggagtc agagaggcgg     1860

aagaagctcc gtttccaccc tcggcagttg tacctgtccg tgaagcaggg cgagctgcag     1920

aaggtgatcc tgatgctgtt ggacaacctg gaccccaact tccagagcga ccagcagagc     1980

aagcgcacgc ccctgcatgc agccgcccag aagggctccg tggagatctg ccatgtgctg     2040

ctgcaggctg gagccaacat aaatgcagtg gacaaacagc agcggacgcc actgatggag     2100

gccgtggtga acaaccacct ggaggtagcc cgttacatgg tgcagcgtgg tggctgtgtc     2160

tatagcaagg aggaggacgg ttccacctgc ctccaccacg cagccaaaat cgggaacttg     2220

gagatggtca gcctgctgct gagcacagga caggtggacg tcaacgccca ggacagtggg     2280

gggtggacgc ccatcatctg ggctgcagag cacaagcaca tcgaggtgat ccgcatgcta     2340

ctgacgcggg gcgccgacgt caccctcact gacaacgagg agaacatctg cctgcactgg     2400

gcctccttca cgggcagcgc cgccatcgcc gaagtccttc tgaatgcgcg ctgtgacctc     2460

catgctgtca actaccatgg ggacaccccc ctgcacatcg cagctcggga gagctaccat     2520

gactgcgtgc tgttattcct gtcacgtggg gccaaccctg agctgcggaa caaagagggg     2580

gacacagcat gggacctgac tcccgagcgc tccgacgtgt ggtttgcgct tcaactcaac     2640

cgcaagctcc gacttggggt gggaaatcgg gccatccgca cagagaagat catctgccgg     2700

gacgtggctc ggggctatga gaacgtgccc attccctgtg tcaacggtgt ggatggggag     2760

ccctgccctg aggattacaa gtacatctca gagaactgcg agacgtccac catgaacatc     2820

gatcgcaaca tcacccacct gcagcactgc acgtgtgtgg acgactgctc tagctccaac     2880

tgcctgtgcg gccagctcag catccggtgc tggtatgaca aggatgggcg attgctccag     2940

gaatttaaca agattgagcc tccgctgatt ttcgagtgta accaggcgtg ctcatgctgg     3000

agaaactgca agaaccgggt cgtacagagt ggcatcaagg tgcggctaca gctctaccga     3060

acagccaaga tgggctgggg ggtccgcgcc ctgcagacca tcccacaggg gaccttcatc     3120

tgcgagtatg tcggggagct gatctctgat gctgaggctg atgtgagaga ggatgattct     3180

tacctcttcg acttagacaa caaggatgga gaggtgtact gcatagatgc ccgttactat     3240

ggcaacatca gccgcttcat caaccacctg tgtgacccca acatcattcc cgtccgggtc     3300

ttcatgctgc accaagacct gcgatttcca cgcatcgcct tcttcagttc ccgagacatc     3360

cggactgggg aggagctagg gtttgactat ggcgaccgct tctgggacat caaaagcaaa     3420

tatttcacct gccaatgtgg ctctgagaag tgcaagcact cagccgaagc cattgccctg     3480

gagcagagcc gtctggcccg cctggaccca caccctgagc tgctgcccga gctcggctcc     3540

ctgccccctg tcaacacatg agaacggacc acaccctctc tccccagcat ggatggccac     3600

agctcagccg cctcctctgc caccagctgc tcgcagccca tgcctggggg tgctgccatc     3660

ttctctcccc accacccttt cacacattcc tgaccagaga tcccagccag gccctggagg     3720

tctgacagcc cctccctccc agagctggtt cctccctggg agggcaactt cagggctggc     3780

caccccccgt gttccccatc ctcagttgaa gtttgatgaa ttgaagtcgg gcctctatgc     3840

caactggttc cttttgttct caataaatgt tgggtttggt aataaaaaaa aaaaaaaaaa     3900


<210>  8
<211>  1176
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ala Ala Ala Gly Ala Ala Ala Ala Ala Ala Ala Glu Gly Glu 
1               5                   10                  15      


Ala Pro Ala Glu Met Gly Ala Leu Leu Leu Glu Lys Glu Thr Arg Gly 
            20                  25                  30          


Ala Thr Glu Arg Val His Gly Ser Leu Gly Asp Thr Pro Arg Ser Glu 
        35                  40                  45              


Glu Thr Leu Pro Lys Ala Thr Pro Asp Ser Leu Glu Pro Ala Gly Pro 
    50                  55                  60                  


Ser Ser Pro Ala Ser Val Thr Val Thr Val Gly Asp Glu Gly Ala Asp 
65                  70                  75                  80  


Thr Pro Val Gly Ala Thr Pro Leu Ile Gly Asp Glu Ser Glu Asn Leu 
                85                  90                  95      


Glu Gly Asp Gly Asp Leu Arg Gly Gly Arg Ile Leu Leu Gly His Ala 
            100                 105                 110         


Thr Lys Ser Phe Pro Ser Ser Pro Ser Lys Gly Gly Ser Cys Pro Ser 
        115                 120                 125             


Arg Ala Lys Met Ser Met Thr Gly Ala Gly Lys Ser Pro Pro Ser Val 
    130                 135                 140                 


Gln Ser Leu Ala Met Arg Leu Leu Ser Met Pro Gly Ala Gln Gly Ala 
145                 150                 155                 160 


Ala Ala Ala Gly Ser Glu Pro Pro Pro Ala Thr Thr Ser Pro Glu Gly 
                165                 170                 175     


Gln Pro Lys Val His Arg Ala Arg Lys Thr Met Ser Lys Pro Gly Asn 
            180                 185                 190         


Gly Gln Pro Pro Val Pro Glu Lys Arg Pro Pro Glu Ile Gln His Phe 
        195                 200                 205             


Arg Met Ser Asp Asp Val His Ser Leu Gly Lys Val Thr Ser Asp Leu 
    210                 215                 220                 


Ala Lys Arg Arg Lys Leu Asn Ser Gly Gly Gly Leu Ser Glu Glu Leu 
225                 230                 235                 240 


Gly Ser Ala Arg Arg Ser Gly Glu Val Thr Leu Thr Lys Gly Asp Pro 
                245                 250                 255     


Gly Ser Leu Glu Glu Trp Glu Thr Val Val Gly Asp Asp Phe Ser Leu 
            260                 265                 270         


Tyr Tyr Asp Ser Tyr Ser Val Asp Glu Arg Val Asp Ser Asp Ser Lys 
        275                 280                 285             


Ser Glu Val Glu Ala Leu Thr Glu Gln Leu Ser Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Glu Asp Glu Glu Ser Gly Asn Gln Ser Asp Arg Ser Gly Ser 
                325                 330                 335     


Ser Gly Arg Arg Lys Ala Lys Lys Lys Trp Arg Lys Asp Ser Pro Trp 
            340                 345                 350         


Val Lys Pro Ser Arg Lys Arg Arg Lys Arg Glu Pro Pro Arg Ala Lys 
        355                 360                 365             


Glu Pro Arg Gly Val Ser Asn Asp Thr Ser Ser Leu Glu Thr Glu Arg 
    370                 375                 380                 


Gly Phe Glu Glu Leu Pro Leu Cys Ser Cys Arg Met Glu Ala Pro Lys 
385                 390                 395                 400 


Ile Asp Arg Ile Ser Glu Arg Ala Gly His Lys Cys Met Ala Thr Glu 
                405                 410                 415     


Ser Val Asp Gly Glu Leu Ser Gly Cys Asn Ala Ala Ile Leu Lys Arg 
            420                 425                 430         


Glu Thr Met Arg Pro Ser Ser Arg Val Ala Leu Met Val Leu Cys Glu 
        435                 440                 445             


Thr His Arg Ala Arg Met Val Lys His His Cys Cys Pro Gly Cys Gly 
    450                 455                 460                 


Tyr Phe Cys Thr Ala Gly Thr Phe Leu Glu Cys His Pro Asp Phe Arg 
465                 470                 475                 480 


Val Ala His Arg Phe His Lys Ala Cys Val Ser Gln Leu Asn Gly Met 
                485                 490                 495     


Val Phe Cys Pro His Cys Gly Glu Asp Ala Ser Glu Ala Gln Glu Val 
            500                 505                 510         


Thr Ile Pro Arg Gly Asp Gly Val Thr Pro Pro Ala Gly Thr Ala Ala 
        515                 520                 525             


Pro Ala Pro Pro Pro Leu Ser Gln Asp Val Pro Gly Arg Ala Asp Thr 
    530                 535                 540                 


Ser Gln Pro Ser Ala Arg Met Arg Gly His Gly Glu Pro Arg Arg Pro 
545                 550                 555                 560 


Pro Cys Asp Pro Leu Ala Asp Thr Ile Asp Ser Ser Gly Pro Ser Leu 
                565                 570                 575     


Thr Leu Pro Asn Gly Gly Cys Leu Ser Ala Val Gly Leu Pro Leu Gly 
            580                 585                 590         


Pro Gly Arg Glu Ala Leu Glu Lys Ala Leu Val Ile Gln Glu Ser Glu 
        595                 600                 605             


Arg Arg Lys Lys Leu Arg Phe His Pro Arg Gln Leu Tyr Leu Ser Val 
    610                 615                 620                 


Lys Gln Gly Glu Leu Gln Lys Val Ile Leu Met Leu Leu Asp Asn Leu 
625                 630                 635                 640 


Asp Pro Asn Phe Gln Ser Asp Gln Gln Ser Lys Arg Thr Pro Leu His 
                645                 650                 655     


Ala Ala Ala Gln Lys Gly Ser Val Glu Ile Cys His Val Leu Leu Gln 
            660                 665                 670         


Ala Gly Ala Asn Ile Asn Ala Val Asp Lys Gln Gln Arg Thr Pro Leu 
        675                 680                 685             


Met Glu Ala Val Val Asn Asn His Leu Glu Val Ala Arg Tyr Met Val 
    690                 695                 700                 


Gln Arg Gly Gly Cys Val Tyr Ser Lys Glu Glu Asp Gly Ser Thr Cys 
705                 710                 715                 720 


Leu His His Ala Ala Lys Ile Gly Asn Leu Glu Met Val Ser Leu Leu 
                725                 730                 735     


Leu Ser Thr Gly Gln Val Asp Val Asn Ala Gln Asp Ser Gly Gly Trp 
            740                 745                 750         


Thr Pro Ile Ile Trp Ala Ala Glu His Lys His Ile Glu Val Ile Arg 
        755                 760                 765             


Met Leu Leu Thr Arg Gly Ala Asp Val Thr Leu Thr Asp Asn Glu Glu 
    770                 775                 780                 


Asn Ile Cys Leu His Trp Ala Ser Phe Thr Gly Ser Ala Ala Ile Ala 
785                 790                 795                 800 


Glu Val Leu Leu Asn Ala Arg Cys Asp Leu His Ala Val Asn Tyr His 
                805                 810                 815     


Gly Asp Thr Pro Leu His Ile Ala Ala Arg Glu Ser Tyr His Asp Cys 
            820                 825                 830         


Val Leu Leu Phe Leu Ser Arg Gly Ala Asn Pro Glu Leu Arg Asn Lys 
        835                 840                 845             


Glu Gly Asp Thr Ala Trp Asp Leu Thr Pro Glu Arg Ser Asp Val Trp 
    850                 855                 860                 


Phe Ala Leu Gln Leu Asn Arg Lys Leu Arg Leu Gly Val Gly Asn Arg 
865                 870                 875                 880 


Ala Ile Arg Thr Glu Lys Ile Ile Cys Arg Asp Val Ala Arg Gly Tyr 
                885                 890                 895     


Glu Asn Val Pro Ile Pro Cys Val Asn Gly Val Asp Gly Glu Pro Cys 
            900                 905                 910         


Pro Glu Asp Tyr Lys Tyr Ile Ser Glu Asn Cys Glu Thr Ser Thr Met 
        915                 920                 925             


Asn Ile Asp Arg Asn Ile Thr His Leu Gln His Cys Thr Cys Val Asp 
    930                 935                 940                 


Asp Cys Ser Ser Ser Asn Cys Leu Cys Gly Gln Leu Ser Ile Arg Cys 
945                 950                 955                 960 


Trp Tyr Asp Lys Asp Gly Arg Leu Leu Gln Glu Phe Asn Lys Ile Glu 
                965                 970                 975     


Pro Pro Leu Ile Phe Glu Cys Asn Gln Ala Cys Ser Cys Trp Arg Asn 
            980                 985                 990         


Cys Lys Asn Arg Val Val Gln Ser  Gly Ile Lys Val Arg  Leu Gln Leu 
        995                 1000                 1005             


Tyr Arg  Thr Ala Lys Met Gly  Trp Gly Val Arg Ala  Leu Gln Thr 
    1010                 1015                 1020             


Ile Pro  Gln Gly Thr Phe Ile  Cys Glu Tyr Val Gly  Glu Leu Ile 
    1025                 1030                 1035             


Ser Asp  Ala Glu Ala Asp Val  Arg Glu Asp Asp Ser  Tyr Leu Phe 
    1040                 1045                 1050             


Asp Leu  Asp Asn Lys Asp Gly  Glu Val Tyr Cys Ile  Asp Ala Arg 
    1055                 1060                 1065             


Tyr Tyr  Gly Asn Ile Ser Arg  Phe Ile Asn His Leu  Cys Asp Pro 
    1070                 1075                 1080             


Asn Ile  Ile Pro Val Arg Val  Phe Met Leu His Gln  Asp Leu Arg 
    1085                 1090                 1095             


Phe Pro  Arg Ile Ala Phe Phe  Ser Ser Arg Asp Ile  Arg Thr Gly 
    1100                 1105                 1110             


Glu Glu  Leu Gly Phe Asp Tyr  Gly Asp Arg Phe Trp  Asp Ile Lys 
    1115                 1120                 1125             


Ser Lys  Tyr Phe Thr Cys Gln  Cys Gly Ser Glu Lys  Cys Lys His 
    1130                 1135                 1140             


Ser Ala  Glu Ala Ile Ala Leu  Glu Gln Ser Arg Leu  Ala Arg Leu 
    1145                 1150                 1155             


Asp Pro  His Pro Glu Leu Leu  Pro Glu Leu Gly Ser  Leu Pro Pro 
    1160                 1165                 1170             


Val Asn  Thr 
    1175     


<210>  9
<211>  4252
<212>  DNA
<213>  Homo sapiens

<400>  9
ggggaggccc ccgctgagat gggggcgctg ctgctggaga aggaaaccag aggagccacc       60

gagagagttc atggctcttt gggggacacc cctcgtagtg aagaaaccct gcccaaggcc      120

acccccgact ccctggagcc tgctggcccc tcatctccag cctctgtcac tgtcactgtt      180

ggtgatgagg gggctgacac ccctgtaggg gctacaccac tcattgggga tgaatctgag      240

aatcttgagg gagatgggga cctccgtggg ggccggatcc tgctgggcca tgccacaaag      300

tcattcccct cttcccccag caaggggggt tcctgtccta gccgggccaa gatgtcaatg      360

acaggggcgg gaaaatcacc tccatctgtc cagagtttgg ctatgaggct actgagtatg      420

ccaggagccc agggagctgc agcagcaggg tctgaacccc ctccagccac cacgagccca      480

gagggacagc ccaaggtcca ccgagcccgc aaaaccatgt ccaaaccagg aaatggacag      540

cataccaaga ccccatctct aaaagaagtt taaaagaatg tttcaaaggc caggcccagt      600

gactcacgcc tgtaatcccg tactttctgg ggaggatcac ttgacaccag gagttcaaga      660

ccagcctggg caacatggca agacctcttc tctaccaaaa aaaaaaatta agaagacatt      720

agttaggcat tgtgacatgt gcctgtaatc ccagcttccc aggaagctga ggcaggagaa      780

tggcttgagt ccagttcgag gctgaagtga gccatagtca tgccactgca ctccatcctg      840

gcccccggtc cctgagaagc ggccccctga aatacagcat ttccgcatga gtgatgatgt      900

ccactcactg ggaaaggtga cctcagatct ggccaaaagg aggaagctga actcaggagg      960

tggcctgtca gaggagttag gttctgcccg gcgttcagga gaagtgaccc tgacgaaagg     1020

ggaccccggg tccctggagg agtgggagac ggtggtgggt gatgacttca gtctctacta     1080

tgattcctac tctgtggatg agcgcgtgga ctccgacagc aagtctgaag ttgaagctct     1140

aactgaacaa ctaagtgaag aggaggagga ggaagaggag gaagaagaag aagaggaaga     1200

ggaggaggaa gaggaagaag aagaggaaga tgaggagtca gggaatcagt cagataggag     1260

tggttccagt ggccggcgca aggccaagaa gaaatggcga aaagacagcc catgggtgaa     1320

gccgtctcgg aaacggcgca agcgggagcc tccgcgggcc aaggagccac gaggagtgaa     1380

tggtgtgggc tcctcaggcc ccagtgagta catggaggtc cctctggggt ccctggagct     1440

gcccagcgag gggaccctct cccccaacca cgctggggtg tccaatgaca catcttcgct     1500

ggagacagag cgagggtttg aggagttgcc cctgtgcagc tgccgcatgg aggcacccaa     1560

gattgaccgc atcagcgaga gggcggggca caagtgcatg gccactgaga gtgtggacgg     1620

agagctgtca ggctgcaatg ccgccatcct caagcgggag accatgaggc catccagccg     1680

tgtggccctg atggtgctct gtgagaccca ccgcgcccgc atggtcaaac accactgctg     1740

cccgggctgc ggctacttct gcacggcggg caccttcctg gagtgccacc ctgacttccg     1800

tgtggcccac cgcttccaca aggcctgtgt gtctcagctg aatgggatgg tcttctgtcc     1860

ccactgtggg gaggatgctt ctgaagctca agaggtgacc atcccccggg gtgacggggt     1920

gaccccaccg gccggcactg cagctcctgc acccccaccc ctgtcccagg atgtccccgg     1980

gagagcagac acttctcagc ccagtgcccg gatgcgaggg catggggaac cccggcgccc     2040

gccctgcgat cccctggctg acaccattga cagctcaggg ccctccctga ccctgcccaa     2100

tgggggctgc ctttcagccg tggggctgcc actggggcca ggccgggagg ccctggaaaa     2160

ggccctggtc atccaggagt cagagaggcg gaagaagctc cgtttccacc ctcggcagtt     2220

gtacctgtcc gtgaagcagg gcgagctgca gaaggtgatc ctgatgctgt tggacaacct     2280

ggaccccaac ttccagagcg accagcagag caagcgcacg cccctgcatg cagccgccca     2340

gaagggctcc gtggagatct gccatgtgct gctgcaggct ggagccaaca taaatgcagt     2400

ggacaaacag cagcggacgc cactgatgga ggccgtggtg aacaaccacc tggaggtagc     2460

ccgttacatg gtgcagcgtg gtggctgtgt ctatagcaag gaggaggacg gttccacctg     2520

cctccaccac gcagccaaaa tcgggaactt ggagatggtc agcctgctgc tgagcacagg     2580

acaggtggac gtcaacgccc aggacagtgg ggggtggacg cccatcatct gggctgcaga     2640

gcacaagcac atcgaggtga tccgcatgct actgacgcgg ggcgccgacg tcaccctcac     2700

tgacaacgtg agtgagcgtt tggttgagga ggagaacatc tgcctgcact gggcctcctt     2760

cacgggcagc gccgccatcg ccgaagtcct tctgaatgcg cgctgtgacc tccatgctgt     2820

caactaccat ggggacaccc ccctgcacat cgcagctcgg gagagctacc atgactgcgt     2880

gctgttattc ctgtcacgtg gggccaaccc tgagctgcgg aacaaagagg gggacacagc     2940

atgggacctg actcccgagc gctccgacgt gtggtttgcg cttcaactca accgcaagct     3000

ccgacttggg gtgggaaatc gggccatccg cacagagaag atcatctgcc gggacgtggc     3060

tcggggctat gagaacgtgc ccattccctg tgtcaacggt gtggatgggg agccctgccc     3120

tgaggattac aagtacatct cagagaactg cgagacgtcc accatgaaca tcgatcgcaa     3180

catcacccac ctgcagcact gcacgtgtgt ggacgactgc tctagctcca actgcctgtg     3240

cggccagctc agcatccggt gctggtatga caaggatggg cgattgctcc aggaatttaa     3300

caagattgag cctccgctga ttttcgagtg taaccaggcg tgctcatgct ggagaaactg     3360

caagaaccgg gtcgtacaga gtggcatcaa ggtgcggcta cagctctacc gaacagccaa     3420

gatgggctgg ggggtccgcg ccctgcagac catcccacag gggaccttca tctgcgagta     3480

tgtcggggag ctgatctctg atgctgaggc tgatgtgaga gaggatgatt cttacctctt     3540

cgacttagac aacaaggatg gagaggtgta ctgcatagat gcccgttact atggcaacat     3600

cagccgcttc atcaaccacc tgtgtgaccc caacatcatt cccgtccggg tcttcatgct     3660

gcaccaagac ctgcgatttc cacgcatcgc cttcttcagt tcccgagaca tccggactgg     3720

ggaggagcta gggtttgact atggcgaccg cttctgggac atcaaaagca aatatttcac     3780

ctgccaatgt ggctctgaga agtgcaagca ctcagccgaa gccattgccc tggagcagag     3840

ccgtctggcc cgcctggacc cacaccctga gctgctgccc gagctcggct ccctgccccc     3900

tgtcaacaca tgagaacgga ccacaccctc tctccccagc atggatggcc acagctcagc     3960

cgcctcctct gccaccagct gctcgcagcc catgcctggg ggtgctgcca tcttctctcc     4020

ccaccaccct ttcacacatt cctgaccaga gatcccagcc aggccctgga ggtctgacag     4080

cccctccctc ccagagctgg ttcctccctg ggagggcaac ttcagggctg gccacccccc     4140

gtgttcccca tcctcagttg aagtttgatg aattgaagtc gggcctctat gccaactggt     4200

tccttttgtt ctcaataaat gttgggtttg gtaataaaaa aaaaaaaaaa aa             4252


<210>  10
<211>  1008
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Asp Asp Val His Ser Leu Gly Lys Val Thr Ser Asp Leu Ala 
1               5                   10                  15      


Lys Arg Arg Lys Leu Asn Ser Gly Gly Gly Leu Ser Glu Glu Leu Gly 
            20                  25                  30          


Ser Ala Arg Arg Ser Gly Glu Val Thr Leu Thr Lys Gly Asp Pro Gly 
        35                  40                  45              


Ser Leu Glu Glu Trp Glu Thr Val Val Gly Asp Asp Phe Ser Leu Tyr 
    50                  55                  60                  


Tyr Asp Ser Tyr Ser Val Asp Glu Arg Val Asp Ser Asp Ser Lys Ser 
65                  70                  75                  80  


Glu Val Glu Ala Leu Thr Glu Gln Leu Ser Glu Glu Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            100                 105                 110         


Glu Glu Asp Glu Glu Ser Gly Asn Gln Ser Asp Arg Ser Gly Ser Ser 
        115                 120                 125             


Gly Arg Arg Lys Ala Lys Lys Lys Trp Arg Lys Asp Ser Pro Trp Val 
    130                 135                 140                 


Lys Pro Ser Arg Lys Arg Arg Lys Arg Glu Pro Pro Arg Ala Lys Glu 
145                 150                 155                 160 


Pro Arg Gly Val Asn Gly Val Gly Ser Ser Gly Pro Ser Glu Tyr Met 
                165                 170                 175     


Glu Val Pro Leu Gly Ser Leu Glu Leu Pro Ser Glu Gly Thr Leu Ser 
            180                 185                 190         


Pro Asn His Ala Gly Val Ser Asn Asp Thr Ser Ser Leu Glu Thr Glu 
        195                 200                 205             


Arg Gly Phe Glu Glu Leu Pro Leu Cys Ser Cys Arg Met Glu Ala Pro 
    210                 215                 220                 


Lys Ile Asp Arg Ile Ser Glu Arg Ala Gly His Lys Cys Met Ala Thr 
225                 230                 235                 240 


Glu Ser Val Asp Gly Glu Leu Ser Gly Cys Asn Ala Ala Ile Leu Lys 
                245                 250                 255     


Arg Glu Thr Met Arg Pro Ser Ser Arg Val Ala Leu Met Val Leu Cys 
            260                 265                 270         


Glu Thr His Arg Ala Arg Met Val Lys His His Cys Cys Pro Gly Cys 
        275                 280                 285             


Gly Tyr Phe Cys Thr Ala Gly Thr Phe Leu Glu Cys His Pro Asp Phe 
    290                 295                 300                 


Arg Val Ala His Arg Phe His Lys Ala Cys Val Ser Gln Leu Asn Gly 
305                 310                 315                 320 


Met Val Phe Cys Pro His Cys Gly Glu Asp Ala Ser Glu Ala Gln Glu 
                325                 330                 335     


Val Thr Ile Pro Arg Gly Asp Gly Val Thr Pro Pro Ala Gly Thr Ala 
            340                 345                 350         


Ala Pro Ala Pro Pro Pro Leu Ser Gln Asp Val Pro Gly Arg Ala Asp 
        355                 360                 365             


Thr Ser Gln Pro Ser Ala Arg Met Arg Gly His Gly Glu Pro Arg Arg 
    370                 375                 380                 


Pro Pro Cys Asp Pro Leu Ala Asp Thr Ile Asp Ser Ser Gly Pro Ser 
385                 390                 395                 400 


Leu Thr Leu Pro Asn Gly Gly Cys Leu Ser Ala Val Gly Leu Pro Leu 
                405                 410                 415     


Gly Pro Gly Arg Glu Ala Leu Glu Lys Ala Leu Val Ile Gln Glu Ser 
            420                 425                 430         


Glu Arg Arg Lys Lys Leu Arg Phe His Pro Arg Gln Leu Tyr Leu Ser 
        435                 440                 445             


Val Lys Gln Gly Glu Leu Gln Lys Val Ile Leu Met Leu Leu Asp Asn 
    450                 455                 460                 


Leu Asp Pro Asn Phe Gln Ser Asp Gln Gln Ser Lys Arg Thr Pro Leu 
465                 470                 475                 480 


His Ala Ala Ala Gln Lys Gly Ser Val Glu Ile Cys His Val Leu Leu 
                485                 490                 495     


Gln Ala Gly Ala Asn Ile Asn Ala Val Asp Lys Gln Gln Arg Thr Pro 
            500                 505                 510         


Leu Met Glu Ala Val Val Asn Asn His Leu Glu Val Ala Arg Tyr Met 
        515                 520                 525             


Val Gln Arg Gly Gly Cys Val Tyr Ser Lys Glu Glu Asp Gly Ser Thr 
    530                 535                 540                 


Cys Leu His His Ala Ala Lys Ile Gly Asn Leu Glu Met Val Ser Leu 
545                 550                 555                 560 


Leu Leu Ser Thr Gly Gln Val Asp Val Asn Ala Gln Asp Ser Gly Gly 
                565                 570                 575     


Trp Thr Pro Ile Ile Trp Ala Ala Glu His Lys His Ile Glu Val Ile 
            580                 585                 590         


Arg Met Leu Leu Thr Arg Gly Ala Asp Val Thr Leu Thr Asp Asn Val 
        595                 600                 605             


Ser Glu Arg Leu Val Glu Glu Glu Asn Ile Cys Leu His Trp Ala Ser 
    610                 615                 620                 


Phe Thr Gly Ser Ala Ala Ile Ala Glu Val Leu Leu Asn Ala Arg Cys 
625                 630                 635                 640 


Asp Leu His Ala Val Asn Tyr His Gly Asp Thr Pro Leu His Ile Ala 
                645                 650                 655     


Ala Arg Glu Ser Tyr His Asp Cys Val Leu Leu Phe Leu Ser Arg Gly 
            660                 665                 670         


Ala Asn Pro Glu Leu Arg Asn Lys Glu Gly Asp Thr Ala Trp Asp Leu 
        675                 680                 685             


Thr Pro Glu Arg Ser Asp Val Trp Phe Ala Leu Gln Leu Asn Arg Lys 
    690                 695                 700                 


Leu Arg Leu Gly Val Gly Asn Arg Ala Ile Arg Thr Glu Lys Ile Ile 
705                 710                 715                 720 


Cys Arg Asp Val Ala Arg Gly Tyr Glu Asn Val Pro Ile Pro Cys Val 
                725                 730                 735     


Asn Gly Val Asp Gly Glu Pro Cys Pro Glu Asp Tyr Lys Tyr Ile Ser 
            740                 745                 750         


Glu Asn Cys Glu Thr Ser Thr Met Asn Ile Asp Arg Asn Ile Thr His 
        755                 760                 765             


Leu Gln His Cys Thr Cys Val Asp Asp Cys Ser Ser Ser Asn Cys Leu 
    770                 775                 780                 


Cys Gly Gln Leu Ser Ile Arg Cys Trp Tyr Asp Lys Asp Gly Arg Leu 
785                 790                 795                 800 


Leu Gln Glu Phe Asn Lys Ile Glu Pro Pro Leu Ile Phe Glu Cys Asn 
                805                 810                 815     


Gln Ala Cys Ser Cys Trp Arg Asn Cys Lys Asn Arg Val Val Gln Ser 
            820                 825                 830         


Gly Ile Lys Val Arg Leu Gln Leu Tyr Arg Thr Ala Lys Met Gly Trp 
        835                 840                 845             


Gly Val Arg Ala Leu Gln Thr Ile Pro Gln Gly Thr Phe Ile Cys Glu 
    850                 855                 860                 


Tyr Val Gly Glu Leu Ile Ser Asp Ala Glu Ala Asp Val Arg Glu Asp 
865                 870                 875                 880 


Asp Ser Tyr Leu Phe Asp Leu Asp Asn Lys Asp Gly Glu Val Tyr Cys 
                885                 890                 895     


Ile Asp Ala Arg Tyr Tyr Gly Asn Ile Ser Arg Phe Ile Asn His Leu 
            900                 905                 910         


Cys Asp Pro Asn Ile Ile Pro Val Arg Val Phe Met Leu His Gln Asp 
        915                 920                 925             


Leu Arg Phe Pro Arg Ile Ala Phe Phe Ser Ser Arg Asp Ile Arg Thr 
    930                 935                 940                 


Gly Glu Glu Leu Gly Phe Asp Tyr Gly Asp Arg Phe Trp Asp Ile Lys 
945                 950                 955                 960 


Ser Lys Tyr Phe Thr Cys Gln Cys Gly Ser Glu Lys Cys Lys His Ser 
                965                 970                 975     


Ala Glu Ala Ile Ala Leu Glu Gln Ser Arg Leu Ala Arg Leu Asp Pro 
            980                 985                 990         


His Pro Glu Leu Leu Pro Glu Leu  Gly Ser Leu Pro Pro  Val Asn Thr 
        995                 1000                 1005             


<210>  11
<211>  4133
<212>  DNA
<213>  Homo sapiens

<400>  11
agagatgcgg ggtctaccga gagggagggg gttgatgcgg gcccggggga ggggtcgtgc       60

ggcccctccg ggcagccgag gccgcggaag gggggggccc cacagaggaa gaggtaggcc      120

ccggagccta ctctctcttc ccagggccca ggcatcctgg accccccaac tctctactgg      180

gctgaccagc cctcctgtcc cttgtctccc ctcccagggg gaggcccccg ctgagatggg      240

ggcgctgctg ctggagaagg aaaccagagg agccaccgag agagttcatg gctctttggg      300

ggacacccct cgtagtgaag aaaccctgcc caaggccacc cccgactccc tggagcctgc      360

tggcccctca tctccagcct ctgtcactgt cactgttggt gatgaggggg ctgacacccc      420

tgtaggggct acaccactca ttggggatga atctgagaat cttgagggag atggggacct      480

ccgtgggggc cggatcctgc tgggccatgc cacaaagtca ttcccctctt cccccagcaa      540

ggggggttcc tgtcctagcc gggccaagat gtcaatgaca ggggcgggaa aatcacctcc      600

atctgtccag agtttggcta tgaggctact gagtatgcca ggagcccagg gagctgcagc      660

agcagggtct gaaccccctc cagccaccac gagcccagag ggacagccca aggtccaccg      720

agcccgcaaa accatgtcca aaccaggaaa tggacagccc ccggtccctg agaagcggcc      780

ccctgaaata cagcatttcc gcatgagtga tgatgtccac tcactgggaa aggtgacctc      840

agatctggcc aaaaggagga agctgaactc aggaggtggc ctgtcagagg agttaggttc      900

tgcccggcgt tcaggagaag tgaccctgac gaaaggggac cccgggtccc tggaggagtg      960

ggagacggtg gtgggtgatg acttcagtct ctactatgat tcctactctg tggatgagcg     1020

cgtggactcc gacagcaagt ctgaagttga agctctaact gaacaactaa gtgaagagga     1080

ggaggaggaa gaggaggaag aagaagaaga ggaagaggag gaggaagagg aagaagaaga     1140

ggaagatgag gagtcaggga atcagtcaga taggagtggt tccagtggcc ggcgcaaggc     1200

caagaagaaa tggcgaaaag acagcccatg ggtgaagccg tctcggaaac ggcgcaagcg     1260

ggagcctccg cgggccaagg agccacgagg agtgaatggt gtgggctcct caggccccag     1320

tgagtacatg gaggtccctc tggggtccct ggagctgccc agcgagggga ccctctcccc     1380

caaccacgct ggggtgtcca atgacacatc ttcgctggag acagagcgag ggtttgagga     1440

gttgcccctg tgcagctgcc gcatggaggc acccaagatt gaccgcatca gcgagagggc     1500

ggggcacaag tgcatggcca ctgagagtgt ggacggagag ctgtcaggct gcaatgccgc     1560

catcctcaag cgggagacca tgaggccatc cagccgtgtg gccctgatgg tgctctgtga     1620

gacccaccgc gcccgcatgg tcaaacacca ctgctgcccg ggctgcggct acttctgcac     1680

ggcgggcacc ttcctggagt gccaccctga cttccgtgtg gcccaccgct tccacaaggc     1740

ctgtgtgtct cagctgaatg ggatggtctt ctgtccccac tgtggggagg atgcttctga     1800

agctcaagag gtgaccatcc cccggggtga cggggtgacc ccaccggccg gcactgcagc     1860

tcctgcaccc ccacccctgt cccaggatgt ccccgggaga gcagacactt ctcagcccag     1920

tgcccggatg cgagggcatg gggaaccccg gcgcccgccc tgcgatcccc tggctgacac     1980

cattgacagc tcagggccct ccctgaccct gcccaatggg ggctgccttt cagccgtggg     2040

gctgccactg gggccaggcc gggaggccct ggaaaaggcc ctggtcatcc aggagtcaga     2100

gaggcggaag aagctccgtt tccaccctcg gcagttgtac ctgtccgtga agcagggcga     2160

gctgcagaag gtgatcctga tgctgttgga caacctggac cccaacttcc agagcgacca     2220

gcagagcaag cgcacgcccc tgcatgcagc cgcccagaag ggctccgtgg agatctgcca     2280

tgtgctgctg caggctggag ccaacataaa tgcagtggac aaacagcagc ggacgccact     2340

gatggaggcc gtggtgaaca accacctgga ggtagcccgt tacatggtgc agcgtggtgg     2400

ctgtgtctat agcaaggagg aggacggttc cacctgcctc caccacgcag ccaaaatcgg     2460

gaacttggag atggtcagcc tgctgctgag cacaggacag gtggacgtca acgcccagga     2520

cagtgggggg tggacgccca tcatctgggc tgcagagcac aagcacatcg aggtgatccg     2580

catgctactg acgcggggcg ccgacgtcac cctcactgac aacgaggaga acatctgcct     2640

gcactgggcc tccttcacgg gcagcgccgc catcgccgaa gtccttctga atgcgcgctg     2700

tgacctccat gctgtcaact accatgggga cacccccctg cacatcgcag ctcgggagag     2760

ctaccatgac tgcgtgctgt tattcctgtc acgtggggcc aaccctgagc tgcggaacaa     2820

agagggggac acagcatggg acctgactcc cgagcgctcc gacgtgtggt ttgcgcttca     2880

actcaaccgc aagctccgac ttggggtggg aaatcgggcc atccgcacag agaagatcat     2940

ctgccgggac gtggctcggg gctatgagaa cgtgcccatt ccctgtgtca acggtgtgga     3000

tggggagccc tgccctgagg attacaagta catctcagag aactgcgaga cgtccaccat     3060

gaacatcgat cgcaacatca cccacctgca gcactgcacg tgtgtggacg actgctctag     3120

ctccaactgc ctgtgcggcc agctcagcat ccggtgctgg tatgacaagg atgggcgatt     3180

gctccaggaa tttaacaaga ttgagcctcc gctgattttc gagtgtaacc aggcgtgctc     3240

atgctggaga aactgcaaga accgggtcgt acagagtggc atcaaggtgc ggctacagct     3300

ctaccgaaca gccaagatgg gctggggggt ccgcgccctg cagaccatcc cacaggggac     3360

cttcatctgc gagtatgtcg gggagctgat ctctgatgct gaggctgatg tgagagagga     3420

tgattcttac ctcttcgact tagacaacaa ggatggagag gtgtactgca tagatgcccg     3480

ttactatggc aacatcagcc gcttcatcaa ccacctgtgt gaccccaaca tcattcccgt     3540

ccgggtcttc atgctgcacc aagacctgcg atttccacgc atcgccttct tcagttcccg     3600

agacatccgg actggggagg agctagggtt tgactatggc gaccgcttct gggacatcaa     3660

aagcaaatat ttcacctgcc aatgtggctc tgagaagtgc aagcactcag ccgaagccat     3720

tgccctggag cagagccgtc tggcccgcct ggacccacac cctgagctgc tgcccgagct     3780

cggctccctg ccccctgtca acacatgaga acggaccaca ccctctctcc ccagcatgga     3840

tggccacagc tcagccgcct cctctgccac cagctgctcg cagcccatgc ctgggggtgc     3900

tgccatcttc tctccccacc accctttcac acattcctga ccagagatcc cagccaggcc     3960

ctggaggtct gacagcccct ccctcccaga gctggttcct ccctgggagg gcaacttcag     4020

ggctggccac cccccgtgtt ccccatcctc agttgaagtt tgatgaattg aagtcgggcc     4080

tctatgccaa ctggttcctt ttgttctcaa taaatgttgg gtttggtaat aaa            4133


<210>  12
<211>  1267
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Gly Leu Pro Arg Gly Arg Gly Leu Met Arg Ala Arg Gly Arg 
1               5                   10                  15      


Gly Arg Ala Ala Pro Pro Gly Ser Arg Gly Arg Gly Arg Gly Gly Pro 
            20                  25                  30          


His Arg Gly Arg Gly Arg Pro Arg Ser Leu Leu Ser Leu Pro Arg Ala 
        35                  40                  45              


Gln Ala Ser Trp Thr Pro Gln Leu Ser Thr Gly Leu Thr Ser Pro Pro 
    50                  55                  60                  


Val Pro Cys Leu Pro Ser Gln Gly Glu Ala Pro Ala Glu Met Gly Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Glu Thr Arg Gly Ala Thr Glu Arg Val His Gly 
                85                  90                  95      


Ser Leu Gly Asp Thr Pro Arg Ser Glu Glu Thr Leu Pro Lys Ala Thr 
            100                 105                 110         


Pro Asp Ser Leu Glu Pro Ala Gly Pro Ser Ser Pro Ala Ser Val Thr 
        115                 120                 125             


Val Thr Val Gly Asp Glu Gly Ala Asp Thr Pro Val Gly Ala Thr Pro 
    130                 135                 140                 


Leu Ile Gly Asp Glu Ser Glu Asn Leu Glu Gly Asp Gly Asp Leu Arg 
145                 150                 155                 160 


Gly Gly Arg Ile Leu Leu Gly His Ala Thr Lys Ser Phe Pro Ser Ser 
                165                 170                 175     


Pro Ser Lys Gly Gly Ser Cys Pro Ser Arg Ala Lys Met Ser Met Thr 
            180                 185                 190         


Gly Ala Gly Lys Ser Pro Pro Ser Val Gln Ser Leu Ala Met Arg Leu 
        195                 200                 205             


Leu Ser Met Pro Gly Ala Gln Gly Ala Ala Ala Ala Gly Ser Glu Pro 
    210                 215                 220                 


Pro Pro Ala Thr Thr Ser Pro Glu Gly Gln Pro Lys Val His Arg Ala 
225                 230                 235                 240 


Arg Lys Thr Met Ser Lys Pro Gly Asn Gly Gln Pro Pro Val Pro Glu 
                245                 250                 255     


Lys Arg Pro Pro Glu Ile Gln His Phe Arg Met Ser Asp Asp Val His 
            260                 265                 270         


Ser Leu Gly Lys Val Thr Ser Asp Leu Ala Lys Arg Arg Lys Leu Asn 
        275                 280                 285             


Ser Gly Gly Gly Leu Ser Glu Glu Leu Gly Ser Ala Arg Arg Ser Gly 
    290                 295                 300                 


Glu Val Thr Leu Thr Lys Gly Asp Pro Gly Ser Leu Glu Glu Trp Glu 
305                 310                 315                 320 


Thr Val Val Gly Asp Asp Phe Ser Leu Tyr Tyr Asp Ser Tyr Ser Val 
                325                 330                 335     


Asp Glu Arg Val Asp Ser Asp Ser Lys Ser Glu Val Glu Ala Leu Thr 
            340                 345                 350         


Glu Gln Leu Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Ser 
    370                 375                 380                 


Gly Asn Gln Ser Asp Arg Ser Gly Ser Ser Gly Arg Arg Lys Ala Lys 
385                 390                 395                 400 


Lys Lys Trp Arg Lys Asp Ser Pro Trp Val Lys Pro Ser Arg Lys Arg 
                405                 410                 415     


Arg Lys Arg Glu Pro Pro Arg Ala Lys Glu Pro Arg Gly Val Asn Gly 
            420                 425                 430         


Val Gly Ser Ser Gly Pro Ser Glu Tyr Met Glu Val Pro Leu Gly Ser 
        435                 440                 445             


Leu Glu Leu Pro Ser Glu Gly Thr Leu Ser Pro Asn His Ala Gly Val 
    450                 455                 460                 


Ser Asn Asp Thr Ser Ser Leu Glu Thr Glu Arg Gly Phe Glu Glu Leu 
465                 470                 475                 480 


Pro Leu Cys Ser Cys Arg Met Glu Ala Pro Lys Ile Asp Arg Ile Ser 
                485                 490                 495     


Glu Arg Ala Gly His Lys Cys Met Ala Thr Glu Ser Val Asp Gly Glu 
            500                 505                 510         


Leu Ser Gly Cys Asn Ala Ala Ile Leu Lys Arg Glu Thr Met Arg Pro 
        515                 520                 525             


Ser Ser Arg Val Ala Leu Met Val Leu Cys Glu Thr His Arg Ala Arg 
    530                 535                 540                 


Met Val Lys His His Cys Cys Pro Gly Cys Gly Tyr Phe Cys Thr Ala 
545                 550                 555                 560 


Gly Thr Phe Leu Glu Cys His Pro Asp Phe Arg Val Ala His Arg Phe 
                565                 570                 575     


His Lys Ala Cys Val Ser Gln Leu Asn Gly Met Val Phe Cys Pro His 
            580                 585                 590         


Cys Gly Glu Asp Ala Ser Glu Ala Gln Glu Val Thr Ile Pro Arg Gly 
        595                 600                 605             


Asp Gly Val Thr Pro Pro Ala Gly Thr Ala Ala Pro Ala Pro Pro Pro 
    610                 615                 620                 


Leu Ser Gln Asp Val Pro Gly Arg Ala Asp Thr Ser Gln Pro Ser Ala 
625                 630                 635                 640 


Arg Met Arg Gly His Gly Glu Pro Arg Arg Pro Pro Cys Asp Pro Leu 
                645                 650                 655     


Ala Asp Thr Ile Asp Ser Ser Gly Pro Ser Leu Thr Leu Pro Asn Gly 
            660                 665                 670         


Gly Cys Leu Ser Ala Val Gly Leu Pro Leu Gly Pro Gly Arg Glu Ala 
        675                 680                 685             


Leu Glu Lys Ala Leu Val Ile Gln Glu Ser Glu Arg Arg Lys Lys Leu 
    690                 695                 700                 


Arg Phe His Pro Arg Gln Leu Tyr Leu Ser Val Lys Gln Gly Glu Leu 
705                 710                 715                 720 


Gln Lys Val Ile Leu Met Leu Leu Asp Asn Leu Asp Pro Asn Phe Gln 
                725                 730                 735     


Ser Asp Gln Gln Ser Lys Arg Thr Pro Leu His Ala Ala Ala Gln Lys 
            740                 745                 750         


Gly Ser Val Glu Ile Cys His Val Leu Leu Gln Ala Gly Ala Asn Ile 
        755                 760                 765             


Asn Ala Val Asp Lys Gln Gln Arg Thr Pro Leu Met Glu Ala Val Val 
    770                 775                 780                 


Asn Asn His Leu Glu Val Ala Arg Tyr Met Val Gln Arg Gly Gly Cys 
785                 790                 795                 800 


Val Tyr Ser Lys Glu Glu Asp Gly Ser Thr Cys Leu His His Ala Ala 
                805                 810                 815     


Lys Ile Gly Asn Leu Glu Met Val Ser Leu Leu Leu Ser Thr Gly Gln 
            820                 825                 830         


Val Asp Val Asn Ala Gln Asp Ser Gly Gly Trp Thr Pro Ile Ile Trp 
        835                 840                 845             


Ala Ala Glu His Lys His Ile Glu Val Ile Arg Met Leu Leu Thr Arg 
    850                 855                 860                 


Gly Ala Asp Val Thr Leu Thr Asp Asn Glu Glu Asn Ile Cys Leu His 
865                 870                 875                 880 


Trp Ala Ser Phe Thr Gly Ser Ala Ala Ile Ala Glu Val Leu Leu Asn 
                885                 890                 895     


Ala Arg Cys Asp Leu His Ala Val Asn Tyr His Gly Asp Thr Pro Leu 
            900                 905                 910         


His Ile Ala Ala Arg Glu Ser Tyr His Asp Cys Val Leu Leu Phe Leu 
        915                 920                 925             


Ser Arg Gly Ala Asn Pro Glu Leu Arg Asn Lys Glu Gly Asp Thr Ala 
    930                 935                 940                 


Trp Asp Leu Thr Pro Glu Arg Ser Asp Val Trp Phe Ala Leu Gln Leu 
945                 950                 955                 960 


Asn Arg Lys Leu Arg Leu Gly Val Gly Asn Arg Ala Ile Arg Thr Glu 
                965                 970                 975     


Lys Ile Ile Cys Arg Asp Val Ala Arg Gly Tyr Glu Asn Val Pro Ile 
            980                 985                 990         


Pro Cys Val Asn Gly Val Asp Gly  Glu Pro Cys Pro Glu  Asp Tyr Lys 
        995                 1000                 1005             


Tyr Ile  Ser Glu Asn Cys Glu  Thr Ser Thr Met Asn  Ile Asp Arg 
    1010                 1015                 1020             


Asn Ile  Thr His Leu Gln His  Cys Thr Cys Val Asp  Asp Cys Ser 
    1025                 1030                 1035             


Ser Ser  Asn Cys Leu Cys Gly  Gln Leu Ser Ile Arg  Cys Trp Tyr 
    1040                 1045                 1050             


Asp Lys  Asp Gly Arg Leu Leu  Gln Glu Phe Asn Lys  Ile Glu Pro 
    1055                 1060                 1065             


Pro Leu  Ile Phe Glu Cys Asn  Gln Ala Cys Ser Cys  Trp Arg Asn 
    1070                 1075                 1080             


Cys Lys  Asn Arg Val Val Gln  Ser Gly Ile Lys Val  Arg Leu Gln 
    1085                 1090                 1095             


Leu Tyr  Arg Thr Ala Lys Met  Gly Trp Gly Val Arg  Ala Leu Gln 
    1100                 1105                 1110             


Thr Ile  Pro Gln Gly Thr Phe  Ile Cys Glu Tyr Val  Gly Glu Leu 
    1115                 1120                 1125             


Ile Ser  Asp Ala Glu Ala Asp  Val Arg Glu Asp Asp  Ser Tyr Leu 
    1130                 1135                 1140             


Phe Asp  Leu Asp Asn Lys Asp  Gly Glu Val Tyr Cys  Ile Asp Ala 
    1145                 1150                 1155             


Arg Tyr  Tyr Gly Asn Ile Ser  Arg Phe Ile Asn His  Leu Cys Asp 
    1160                 1165                 1170             


Pro Asn  Ile Ile Pro Val Arg  Val Phe Met Leu His  Gln Asp Leu 
    1175                 1180                 1185             


Arg Phe  Pro Arg Ile Ala Phe  Phe Ser Ser Arg Asp  Ile Arg Thr 
    1190                 1195                 1200             


Gly Glu  Glu Leu Gly Phe Asp  Tyr Gly Asp Arg Phe  Trp Asp Ile 
    1205                 1210                 1215             


Lys Ser  Lys Tyr Phe Thr Cys  Gln Cys Gly Ser Glu  Lys Cys Lys 
    1220                 1225                 1230             


His Ser  Ala Glu Ala Ile Ala  Leu Glu Gln Ser Arg  Leu Ala Arg 
    1235                 1240                 1245             


Leu Asp  Pro His Pro Glu Leu  Leu Pro Glu Leu Gly  Ser Leu Pro 
    1250                 1255                 1260             


Pro Val  Asn Thr 
    1265         


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hMAP1LC3B F primer

<400>  13
aggagataca agggaagtgg ct                                                22


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hMAP1LC3B R primer

<400>  14
ttgaaggtct tctccgacgg cat                                               23


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hMAP1LC3B F 5 kb primer

<400>  15
atcttggctc actgcaacct                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hMAP1LC3B R 5 kb primer

<400>  16
gtttgcgtcc tttccctgta                                                   20


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RT hMAP1LC3B F primer

<400>  17
gatgtccgac ttattcgaga gc                                                22


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RT hMAP1LC3B R primer

<400>  18
ttgagctgta agcgccttct a                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RT hBeclin1 F primer

<400>  19
ggctgagaga ctggatcagg                                                   20


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RT hBeclin1 R primer

<400>  20
ctgcgtctgg gcataacg                                                     18


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RT hBNIP3L F primer

<400>  21
cgtcttccat ccacaatgga g                                                 21


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RT hBNIP3L R primer

<400>  22
ttgtggtgaa gggctgtcac                                                   20


<210>  23
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RT hHPRT F primer

<400>  23
tgcagacttt gctttccttg gtcagg                                            26


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RT hHPRT R primer

<400>  24
ccaacacttc gtggggtcct tttca                                             25


<210>  25
<211>  5123
<212>  DNA
<213>  Homo sapiens

<400>  25
gcgcgggagg ggcggggcca cgctgcgggc ccgggccatg gccgccgccg atgccgaggc       60

agttccggcg aggggggagc ctcagcagga ttgctgtgtg aaaaccgagc tgctgggaga      120

agagacacct atggctgccg atgaaggctc agcagagaaa caggcaggag aggcccacat      180

ggctgcggac ggtgagacca atgggtcttg tgaaaacagc gatgccagca gtcatgcaaa      240

tgctgcaaag cacactcagg acagcgcaag ggtcaacccc caggatggca ccaacacact      300

aactcggata gcggaaaatg gggtttcaga aagagactca gaagcggcga agcaaaacca      360

cgtcactgcc gacgactttg tgcagacttc tgtcatcggc agcaacggat acatcttaaa      420

taagccggcc ctacaggcac agcccttgag gactaccagc actctggcct cttcgctgcc      480

tggccatgct gcaaaaaccc ttcctggagg ggctggcaaa ggcaggactc caagcgcttt      540

tccccagacg ccagccgccc caccagccac ccttggggag gggagtgctg acacagagga      600

caggaagctc ccggcccctg gcgccgacgt caaggtccac agggcacgca agaccatgcc      660

gaagtccgtc gtgggcctgc atgcagccag taaagatccc agagaagttc gagaagctag      720

agatcataag gaaccaaaag aggagatcaa caaaaacatt tctgactttg gacgacagca      780

gcttttaccc cccttcccat cccttcatca gtcgctacct cagaaccagt gctacatggc      840

caccacaaaa tcacagacag cttgcttgcc ttttgtttta gcagctgcag tatctcggaa      900

gaaaaaacga agaatgggaa cctatagcct ggttcctaag aaaaagacca aagtattaaa      960

acagaggacg gtgattgaga tgtttaagag cataactcat tccactgtgg gttccaaggg     1020

ggagaaggac ctgggcgcca gcagcctgca cgtgaatggg gagagcctgg agatggactc     1080

ggatgaggac gactcagagg agctcgagga ggacgacggc catggtgcag agcaggcggc     1140

cgcgttcccc acagaggaca gcaggacttc caaggagagc atgtcggagg ctgatcgcgc     1200

ccagaagatg gacggggagt ccgaggagga gcaggagtcc gtggacaccg gggaggagga     1260

ggaaggcggt gacgagtctg acctgagttc ggaatccagc attaagaaga aatttctcaa     1320

gaggaaagga aagaccgaca gtccctggat caagccagcc aggaaaagga ggcggagaag     1380

tagaaagaag cccagcggtg ccctcggttc tgagtcgtat aagtcatctg caggaagcgc     1440

tgagcagacg gcaccaggag acagcacagg gtacatggaa gtttctctgg actccctgga     1500

tctccgagtc aaaggaattc tgtcttcaca agcagaaggg ttggccaacg gtccagatgt     1560

gctggagaca gacggcctcc aggaagtgcc tctctgcagc tgccggatgg aaacaccgaa     1620

gagtcgagag atcaccacac tggccaacaa ccagtgcatg gctacagaga gcgtggacca     1680

tgaattgggc cggtgcacaa acagcgtggt caagtatgag ctgatgcgcc cctccaacaa     1740

ggccccgctc ctcgtgctgt gtgaagacca ccggggccgc atggtgaagc accagtgctg     1800

tcctggctgt ggctacttct gcacagcggg taattttatg gagtgtcagc ccgagagcag     1860

catctctcac cgtttccaca aagactgtgc ctctcgagtc aataacgcca gctattgtcc     1920

ccactgtggg gaggagagct ccaaggccaa agaggtgacg atagctaaag cagacaccac     1980

ctcgaccgtg acaccagtcc ccgggcagga gaagggctcg gccctggagg gcagggccga     2040

caccacaacg ggcagtgctg ccgggccacc actctcggag gacgacaagc tgcagggtgc     2100

agcctcccac gtgcccgagg gctttgatcc aacgggacct gctgggcttg ggaggccaac     2160

tcccggcctt tcccagggac cagggaagga aaccttggag agcgctctca tcgccctcga     2220

ctcggaaaaa cccaagaagc ttcgcttcca cccaaagcag ctgtacttct ccgccaggca     2280

aggggagctt cagaaggtgc tcctcatgct ggtggacgga attgacccca acttcaaaat     2340

ggagcaccag aataagcgct ctccactgca cgccgcggca gaggctggac acgtggacat     2400

ctgccacatg ctggttcagg cgggcgctaa tattgacacc tgctcagaag accagaggac     2460

cccgttgatg gaagcagccg aaaacaacca tctggaagca gtgaagtacc tcatcaaggc     2520

tggggccctg gtggatccca aggacgcaga gggctctacg tgtttgcacc tggctgccaa     2580

gaaaggccac tacgaagtgg tccagtacct gctttcaaat ggacagatgg acgtcaactg     2640

tcaggatgac ggaggctgga cacccatgat ctgggccaca gagtacaagc acgtggacct     2700

cgtgaagctg ctgctgtcca agggctctga catcaacatc cgagacaacg aggagaacat     2760

ttgcctgcac tgggcggcgt tctccggctg cgtggacata gccgagatcc tgctggctgc     2820

caagtgcgac ctccacgccg tgaacatcca cggagactcg ccactgcaca ttgccgcccg     2880

ggagaaccgc tacgactgtg tcgtcctctt tctttctcgg gattcagatg tcaccttaaa     2940

gaacaaggaa ggagagacgc ccctgcagtg tgcgagcctc aactctcagg tgtggagcgc     3000

tctgcagatg agcaaggctc tgcaggactc ggcccccgac aggcccagcc ccgtggagag     3060

gatagtgagc agggacatcg ctcgaggcta cgagcgcatc cccatcccct gtgtcaacgc     3120

cgtggacagc gagccatgcc ccagcaacta caagtacgtc tctcagaact gcgtgacgtc     3180

ccccatgaac atcgacagaa atatcactca tctgcagtac tgcgtgtgca tcgacgactg     3240

ctcctccagc aactgcatgt gcggccagct cagcatgcgc tgctggtacg acaaggatgg     3300

ccggctcctg ccagagttca acatggcgga gcctcccttg atcttcgaat gcaaccacgc     3360

gtgctcctgc tggaggaact gccgaaatcg cgtcgtacag aatggtctca gggcaaggct     3420

gcagctctac cggacgcggg acatgggctg gggcgtgcgg tccctgcagg acatcccacc     3480

aggcaccttt gtctgcgagt atgttgggga gctgatttca gactcagaag ccgacgttcg     3540

agaggaagat tcttacctct ttgatctcga caataaggac ggggaggttt actgcatcga     3600

cgcgcggttc tacgggaacg tcagccggtt catcaaccac cactgcgagc ccaacctggt     3660

gcccgtgcgc gtgttcatgg cccaccagga cctgcggttc ccccggatcg ccttcttcag     3720

cacccgcctg atcgaggccg gcgagcagct cgggtttgac tatggagagc gcttctggga     3780

catcaaaggc aagctcttca gctgccgctg cggctccccc aagtgccggc actcgagcgc     3840

ggccctggcc cagcgtcagg ccagcgcggc ccaggaggcc caggaggacg gcttgcccga     3900

caccagctcc gcggctgccg ccgaccccct atgagacgcc gccggccagc ggggcgctcg     3960

ggagccaggg accgccgcgt cgccgattag aggacgagga ggagagattc cgcacgcaac     4020

cgaaagggtc cttcggggct gcgccgccgg cttcctggag gggtcggagg tgaggctgca     4080

gcccctgcgg gcgggtgtgg atgcctccca gccaccttcc cagacctgcg gcctcaccgc     4140

gggcccagtg cccaggctgg agcgcacact ttggtccgcg cgccagagac gctgggagtc     4200

cgcactggca tcaccttctg agtttctgat gctgatttgt cgttgcgaag tttctcgttt     4260

cttcctctga cctccgaggt ccccgctgca ccacggggtt gctctgttct cctgtccggc     4320

ccagactctt ctgtgtggcg ccgccgaagc caccgttagc gcgagctgct ccgttcgccc     4380

tgcccacggc ctgcgtggct ggggccgagt cccaggggcc gcacggaggg cacagtctcc     4440

tgtcaggctc ggagaggtca ggagaccgac cccaccacta actttggaga aaatgtgggt     4500

ttgcttttta aaggaatcct atatctagtc ctatatatca aacctctaac tgacgtttct     4560

tttcgaggaa gtggcttggt gggtgcagcc cccgccggtt ccgttgacgc tggcaccttc     4620

tgttgatttt ttaagccaca tgctatgatg aataaactga tttattttct accattactg     4680

aacattagga caaacacaaa ataaaaaaca aaacacagac aacggtgctg attctggtgt     4740

ggtttctact caccacgtga aataaactat caactgtata aagagaacaa agtgatttta     4800

gaataaaatg caggaaaaac ttttttaaag atgttagtct tgtagcgtga ataaatttgc     4860

catcaccttt tgtgtggtgg cctggcaggt catatacttt tttttggcat ataccttttt     4920

aaagactgta attagtgcag taacagtggg gttttttttg tgcaactctt ctaaaaacat     4980

tcataatgca gtcatgttta tttttttctg ttaaaatgtt tttgacagtt ttaagagcag     5040

tcttttggct ctgaccattt cttgttctgt ttccaatgaa atcaataaaa aaaaagaagt     5100

actttaaaaa aaaaaaaaaa aaa                                             5123


<210>  26
<211>  1298
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ala Ala Asp Ala Glu Ala Val Pro Ala Arg Gly Glu Pro Gln 
1               5                   10                  15      


Gln Asp Cys Cys Val Lys Thr Glu Leu Leu Gly Glu Glu Thr Pro Met 
            20                  25                  30          


Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His Met 
        35                  40                  45              


Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala Ser 
    50                  55                  60                  


Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val Asn 
65                  70                  75                  80  


Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly Val 
                85                  90                  95      


Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala Asp 
            100                 105                 110         


Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu Asn 
        115                 120                 125             


Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala 
    130                 135                 140                 


Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly 
145                 150                 155                 160 


Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro 
                165                 170                 175     


Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro 
            180                 185                 190         


Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro 
        195                 200                 205             


Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu Val 
    210                 215                 220                 


Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys Asn 
225                 230                 235                 240 


Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser Leu 
                245                 250                 255     


His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys Ser 
            260                 265                 270         


Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys 
        275                 280                 285             


Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr 
    290                 295                 300                 


Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr 
305                 310                 315                 320 


His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser 
                325                 330                 335     


Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp 
            340                 345                 350         


Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala 
        355                 360                 365             


Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu 
    370                 375                 380                 


Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu 
385                 390                 395                 400 


Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu 
                405                 410                 415     


Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys 
            420                 425                 430         


Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser 
        435                 440                 445             


Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser 
    450                 455                 460                 


Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met 
465                 470                 475                 480 


Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser 
                485                 490                 495     


Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp 
            500                 505                 510         


Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys 
        515                 520                 525             


Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu 
    530                 535                 540                 


Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys Tyr 
545                 550                 555                 560 


Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys Glu 
                565                 570                 575     


Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro Gly Cys Gly 
            580                 585                 590         


Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro Glu Ser Ser 
        595                 600                 605             


Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn Ala 
    610                 615                 620                 


Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu Val 
625                 630                 635                 640 


Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro Gly 
                645                 650                 655     


Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr Gly 
            660                 665                 670         


Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly Ala 
        675                 680                 685             


Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly Leu 
    690                 695                 700                 


Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr Leu 
705                 710                 715                 720 


Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys Leu Arg 
                725                 730                 735     


Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu Gln 
            740                 745                 750         


Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys Met 
        755                 760                 765             


Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala Gly 
    770                 775                 780                 


His Val Asp Ile Cys His Met Leu Val Gln Ala Gly Ala Asn Ile Asp 
785                 790                 795                 800 


Thr Cys Ser Glu Asp Gln Arg Thr Pro Leu Met Glu Ala Ala Glu Asn 
                805                 810                 815     


Asn His Leu Glu Ala Val Lys Tyr Leu Ile Lys Ala Gly Ala Leu Val 
            820                 825                 830         


Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys Leu His Leu Ala Ala Lys 
        835                 840                 845             


Lys Gly His Tyr Glu Val Val Gln Tyr Leu Leu Ser Asn Gly Gln Met 
    850                 855                 860                 


Asp Val Asn Cys Gln Asp Asp Gly Gly Trp Thr Pro Met Ile Trp Ala 
865                 870                 875                 880 


Thr Glu Tyr Lys His Val Asp Leu Val Lys Leu Leu Leu Ser Lys Gly 
                885                 890                 895     


Ser Asp Ile Asn Ile Arg Asp Asn Glu Glu Asn Ile Cys Leu His Trp 
            900                 905                 910         


Ala Ala Phe Ser Gly Cys Val Asp Ile Ala Glu Ile Leu Leu Ala Ala 
        915                 920                 925             


Lys Cys Asp Leu His Ala Val Asn Ile His Gly Asp Ser Pro Leu His 
    930                 935                 940                 


Ile Ala Ala Arg Glu Asn Arg Tyr Asp Cys Val Val Leu Phe Leu Ser 
945                 950                 955                 960 


Arg Asp Ser Asp Val Thr Leu Lys Asn Lys Glu Gly Glu Thr Pro Leu 
                965                 970                 975     


Gln Cys Ala Ser Leu Asn Ser Gln Val Trp Ser Ala Leu Gln Met Ser 
            980                 985                 990         


Lys Ala Leu Gln Asp Ser Ala Pro  Asp Arg Pro Ser Pro  Val Glu Arg 
        995                 1000                 1005             


Ile Val  Ser Arg Asp Ile Ala  Arg Gly Tyr Glu Arg  Ile Pro Ile 
    1010                 1015                 1020             


Pro Cys  Val Asn Ala Val Asp  Ser Glu Pro Cys Pro  Ser Asn Tyr 
    1025                 1030                 1035             


Lys Tyr  Val Ser Gln Asn Cys  Val Thr Ser Pro Met  Asn Ile Asp 
    1040                 1045                 1050             


Arg Asn  Ile Thr His Leu Gln  Tyr Cys Val Cys Ile  Asp Asp Cys 
    1055                 1060                 1065             


Ser Ser  Ser Asn Cys Met Cys  Gly Gln Leu Ser Met  Arg Cys Trp 
    1070                 1075                 1080             


Tyr Asp  Lys Asp Gly Arg Leu  Leu Pro Glu Phe Asn  Met Ala Glu 
    1085                 1090                 1095             


Pro Pro  Leu Ile Phe Glu Cys  Asn His Ala Cys Ser  Cys Trp Arg 
    1100                 1105                 1110             


Asn Cys  Arg Asn Arg Val Val  Gln Asn Gly Leu Arg  Ala Arg Leu 
    1115                 1120                 1125             


Gln Leu  Tyr Arg Thr Arg Asp  Met Gly Trp Gly Val  Arg Ser Leu 
    1130                 1135                 1140             


Gln Asp  Ile Pro Pro Gly Thr  Phe Val Cys Glu Tyr  Val Gly Glu 
    1145                 1150                 1155             


Leu Ile  Ser Asp Ser Glu Ala  Asp Val Arg Glu Glu  Asp Ser Tyr 
    1160                 1165                 1170             


Leu Phe  Asp Leu Asp Asn Lys  Asp Gly Glu Val Tyr  Cys Ile Asp 
    1175                 1180                 1185             


Ala Arg  Phe Tyr Gly Asn Val  Ser Arg Phe Ile Asn  His His Cys 
    1190                 1195                 1200             


Glu Pro  Asn Leu Val Pro Val  Arg Val Phe Met Ala  His Gln Asp 
    1205                 1210                 1215             


Leu Arg  Phe Pro Arg Ile Ala  Phe Phe Ser Thr Arg  Leu Ile Glu 
    1220                 1225                 1230             


Ala Gly  Glu Gln Leu Gly Phe  Asp Tyr Gly Glu Arg  Phe Trp Asp 
    1235                 1240                 1245             


Ile Lys  Gly Lys Leu Phe Ser  Cys Arg Cys Gly Ser  Pro Lys Cys 
    1250                 1255                 1260             


Arg His  Ser Ser Ala Ala Leu  Ala Gln Arg Gln Ala  Ser Ala Ala 
    1265                 1270                 1275             


Gln Glu  Ala Gln Glu Asp Gly  Leu Pro Asp Thr Ser  Ser Ala Ala 
    1280                 1285                 1290             


Ala Ala  Asp Pro Leu 
    1295             


<210>  27
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu 
1               5                   10                  15      


Gln Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu 
        35                  40                  45              


Ala Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly 
65                  70                  75                  80  


Lys Asp Tyr Asn Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala 
                85                  90                  95      


Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
            100                 105                 110         


Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser 
        115                 120                 125             


Pro Asn Cys Lys Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu 
                165                 170                 175     


Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly 
        195                 200                 205             


Val Ser Leu Lys Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys 
    210                 215                 220                 


Glu Gln Trp Lys Glu Val His Lys Gln Val Val Glu Ser Ala Tyr Glu 
225                 230                 235                 240 


Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val 
                245                 250                 255     


Ala Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         


Val Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Asp Asp Val Phe 
        275                 280                 285             


Leu Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Leu Val 
    290                 295                 300                 


Lys Val Thr Leu Thr Ser Glu Glu Glu Ala Arg Leu Lys Lys Ser Ala 
305                 310                 315                 320 


Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe 
                325                 330         


<210>  28
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     


Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 


Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
225                 230                 235                 240 


Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                245                 250                 255     


Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
            260                 265                 270         


Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
        275                 280                 285             


Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
    290                 295                 300                 


Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
305                 310                 315                 320 


Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                325                 330                 


