                         SEQUENCE LISTING

<110>  THE UAB RESEARCH FOUNDATION
 
<120>  Production and Detection of Bioactive Soluble Klotho Protein

<130>  03258.0078

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         


Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             


Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 


Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     


Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         


Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             


Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     


Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         


Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             


Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 


Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 


Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         


Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             


Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 


Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     


Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         


Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             


Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 


Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 


Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn 
                805                 810                 815     


Gly Gly Leu Lys Arg Arg 
            820         


<210>  2
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  3
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 


Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 


Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     


Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
            420                 425                 430         


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
        435                 440                 445             


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
    450                 455                 460                 


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
465                 470                 475                 480 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
                485                 490                 495     


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
            500                 505                 510         


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        515                 520                 525             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    530                 535                 540                 


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
545                 550                 555                 560 


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
                565                 570                 575     


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
            580                 585                 590         


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
        595                 600                 605             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    610                 615                 620                 


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
625                 630                 635                 640 


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                645                 650                 655     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            660                 665                 670         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
        675                 680                 685             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    690                 695                 700                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
705                 710                 715                 720 


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
                725                 730                 735     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
            740                 745                 750         


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
        755                 760                 765             


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
    770                 775                 780                 


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
785                 790                 795                 800 


Ser Gly Gly Ser Arg Thr 
                805     


<210>  4
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210>  5
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  6
<211>  822
<212>  PRT
<213>  Mus musculus

<400>  6

Met Trp Gly Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ala Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Val Pro Val Glu Val Glu Ser Leu Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Val Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Arg Asp Ser Ile Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Arg Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Leu Gly Ser Val Ile Ile Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         


Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             


Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 


Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     


Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         


Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             


Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     


Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         


Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             


Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 


Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 


Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         


Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             


Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 


Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     


Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         


Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             


Leu Ser Ile Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 


Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 


Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Thr Gln Leu Ala Asn 
                805                 810                 815     


Ser Gly Leu Lys Arg Arg 
            820         


<210>  7
<211>  821
<212>  PRT
<213>  Mus musculus

<400>  7

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Leu Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Ala Tyr Val Val Ala Pro Gly Glu Ser Leu Glu Leu Gln Cys Met Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ala Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Ile Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Ser Ser Glu Asp Val Val 
    130                 135                 140                 


Ser Glu Asn Arg Ser Asn Gln Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Cys Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Thr Ser Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Leu Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Asn Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Val Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Phe Cys Arg Met 
385                 390                 395                 400 


Lys Thr Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Thr Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Thr Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Ser Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  8
<211>  801
<212>  PRT
<213>  Mus musculus

<400>  8

Met Val Val Pro Ala Cys Val Leu Val Phe Cys Val Ala Val Val Ala 
1               5                   10                  15      


Gly Ala Thr Ser Glu Pro Pro Gly Pro Glu Gln Arg Val Val Arg Arg 
            20                  25                  30          


Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Gln Gln Glu Gln Val Ala 
        35                  40                  45              


Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys His Pro Pro Gly Gly 
    50                  55                  60                  


Ala Pro Thr Gly Pro Thr Val Trp Ala Lys Asp Gly Thr Gly Leu Val 
65                  70                  75                  80  


Ala Ser His Arg Ile Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn 
                85                  90                  95      


Ala Ser His Glu Asp Ala Gly Val Tyr Ser Cys Gln His Arg Leu Thr 
            100                 105                 110         


Arg Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser 
        115                 120                 125             


Ser Gly Asp Asp Glu Asp Gly Glu Asp Val Ala Glu Asp Thr Gly Ala 
    130                 135                 140                 


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
145                 150                 155                 160 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
                165                 170                 175     


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu 
            180                 185                 190         


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
        195                 200                 205             


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
    210                 215                 220                 


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
225                 230                 235                 240 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                245                 250                 255     


Gln Thr Ala Ile Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
            260                 265                 270         


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
        275                 280                 285             


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
    290                 295                 300                 


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
305                 310                 315                 320 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
            340                 345                 350         


Ala Glu Glu Glu Leu Met Glu Thr Asp Glu Ala Gly Ser Val Tyr Ala 
        355                 360                 365             


Gly Val Leu Ser Tyr Gly Val Val Phe Phe Leu Phe Ile Leu Val Val 
    370                 375                 380                 


Ala Ala Val Ile Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu 
385                 390                 395                 400 


Gly Ser Pro Thr Val His Lys Val Ser Arg Phe Pro Leu Lys Arg Gln 
                405                 410                 415     


Val Ser Leu Glu Ser Asn Ser Ser Met Asn Ser Asn Thr Pro Leu Val 
            420                 425                 430         


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Val Leu Ala Asn Val 
        435                 440                 445             


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Thr 
    450                 455                 460                 


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
465                 470                 475                 480 


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Thr Ala Lys Pro 
                485                 490                 495     


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
            500                 505                 510         


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
        515                 520                 525             


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
    530                 535                 540                 


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
545                 550                 555                 560 


Leu Arg Ala Arg Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp Ala Cys 
                565                 570                 575     


Arg Leu Pro Glu Glu Gln Leu Thr Cys Lys Asp Leu Val Ser Cys Ala 
            580                 585                 590         


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
        595                 600                 605             


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
    610                 615                 620                 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
625                 630                 635                 640 


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
                645                 650                 655     


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
            660                 665                 670         


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Pro Gly Gly Pro Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu 
    690                 695                 700                 


Gly His Arg Met Asp Lys Pro Ala Ser Cys Thr His Asp Leu Tyr Met 
705                 710                 715                 720 


Ile Met Arg Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Val Thr Ser Thr 
            740                 745                 750         


Asp Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro Gly 
        755                 760                 765             


Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe 
    770                 775                 780                 


Thr His Asp Leu Leu Pro Pro Gly Pro Pro Ser Asn Gly Gly Pro Arg 
785                 790                 795                 800 


Thr 
    


<210>  9
<211>  799
<212>  PRT
<213>  Mus musculus

<400>  9

Met Trp Leu Leu Leu Ala Leu Leu Ser Ile Phe Gln Gly Thr Pro Ala 
1               5                   10                  15      


Leu Ser Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Leu Ala 
            20                  25                  30          


Pro Ile Leu Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln 
        35                  40                  45              


Pro Val Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr 
    50                  55                  60                  


Lys Glu Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg 
65                  70                  75                  80  


Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr 
                85                  90                  95      


Leu Cys Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu 
            100                 105                 110         


Leu Met Asp Asp Ser Leu Thr Ser Ile Ser Asn Asp Glu Asp Pro Lys 
        115                 120                 125             


Thr Leu Ser Ser Ser Ser Ser Gly His Val Tyr Pro Gln Gln Ala Pro 
    130                 135                 140                 


Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro 
145                 150                 155                 160 


Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met 
                165                 170                 175     


Pro Thr Ile His Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn 
            180                 185                 190         


Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met 
        195                 200                 205             


Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu 
    210                 215                 220                 


Asn Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu 
225                 230                 235                 240 


Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr 
                245                 250                 255     


Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser 
            260                 265                 270         


Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Val Ile Asn Gly 
        275                 280                 285             


Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr 
    290                 295                 300                 


Thr Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val 
305                 310                 315                 320 


Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
                325                 330                 335     


Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp 
            340                 345                 350         


Leu Thr Trp Thr Thr Ala Thr Pro Glu Ala Arg Tyr Thr Asp Ile Ile 
        355                 360                 365             


Leu Tyr Val Ser Gly Ser Leu Val Leu Leu Val Leu Leu Leu Leu Ala 
    370                 375                 380                 


Gly Val Tyr His Arg Gln Val Ile Arg Gly His Tyr Ser Arg Gln Pro 
385                 390                 395                 400 


Val Thr Ile Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe Ser 
                405                 410                 415     


Leu Glu Ser Arg Ser Ser Gly Lys Ser Ser Leu Ser Leu Val Arg Gly 
            420                 425                 430         


Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Thr Gly Leu Val Asn 
        435                 440                 445             


Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu 
    450                 455                 460                 


Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg 
465                 470                 475                 480 


Ala Glu Ala Phe Gly Met Asp Pro Ser Arg Pro Asp Gln Thr Ser Thr 
                485                 490                 495     


Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala 
            500                 505                 510         


Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly Arg His Lys 
        515                 520                 525             


Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr 
    530                 535                 540                 


Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg 
545                 550                 555                 560 


Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser 
                565                 570                 575     


Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr Gln 
            580                 585                 590         


Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg 
        595                 600                 605             


Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asp Val Met Lys 
    610                 615                 620                 


Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr 
625                 630                 635                 640 


Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu 
                645                 650                 655     


Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe 
            660                 665                 670         


Glu Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro 
        675                 680                 685             


Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg 
    690                 695                 700                 


Met Glu Arg Pro Pro Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met Arg 
705                 710                 715                 720 


Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu 
                725                 730                 735     


Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu 
            740                 745                 750         


Asp Leu Arg Leu Thr Phe Gly Pro Phe Ser Pro Ser Asn Gly Asp Ala 
        755                 760                 765             


Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu 
    770                 775                 780                 


Pro Leu Glu Pro Ser Pro Phe Pro Phe Ser Asp Ser Gln Thr Thr 
785                 790                 795                 


<210>  10
<211>  251
<212>  PRT
<213>  Mus musculus

<400>  10

Met Leu Gly Thr Cys Leu Arg Leu Leu Val Gly Val Leu Cys Thr Val 
1               5                   10                  15      


Cys Ser Leu Gly Thr Ala Arg Ala Tyr Pro Asp Thr Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Asn Trp Gly Ser Leu Thr His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Thr Ser Tyr His Leu Gln Ile His Arg Asp Gly His Val Asp Gly Thr 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Thr Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Ser Val Val Ile Thr Gly Ala Met Thr Arg Arg Phe Leu Cys Met 
                85                  90                  95      


Asp Leu His Gly Asn Ile Phe Gly Ser Leu His Phe Ser Pro Glu Asn 
            100                 105                 110         


Cys Lys Phe Arg Gln Trp Thr Leu Glu Asn Gly Tyr Asp Val Tyr Leu 
        115                 120                 125             


Ser Gln Lys His His Tyr Leu Val Ser Leu Gly Arg Ala Lys Arg Ile 
    130                 135                 140                 


Phe Gln Pro Gly Thr Asn Pro Pro Pro Phe Ser Gln Phe Leu Ala Arg 
145                 150                 155                 160 


Arg Asn Glu Val Pro Leu Leu His Phe Tyr Thr Val Arg Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Pro Pro Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Pro Arg Ala Thr Pro Val Pro Val Ser Cys Ser Arg 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Glu Gly Gly Pro Ala Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Leu Arg Arg Gly Arg Gly Asp Ala Arg Gly Gly Ala Gly Gly 
225                 230                 235                 240 


Ala Asp Arg Cys Arg Pro Phe Pro Arg Phe Val 
                245                 250     


<210>  11
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  12
<211>  1014
<212>  PRT
<213>  Mus musculus

<400>  12

Met Leu Ala Arg Ala Pro Pro Arg Arg Pro Pro Arg Leu Val Leu Leu 
1               5                   10                  15      


Arg Leu Leu Leu Leu His Leu Leu Leu Leu Ala Leu Arg Ala Arg Cys 
            20                  25                  30          


Leu Ser Ala Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Ala Pro Ala Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro 
    50                  55                  60                  


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Arg Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
                85                  90                  95      


His His Ser Gly Ala Ala Pro Ser Asp Ser Pro Ile Val Val Ala Pro 
            100                 105                 110         


Ser Gly Ala Pro Ser Pro Pro Leu Ser Ser Thr Gly Asp Val Ala Ser 
        115                 120                 125             


Asp Ser Tyr Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
145                 150                 155                 160 


Asn Gly Thr Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly 
        195                 200                 205             


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
    210                 215                 220                 


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
225                 230                 235                 240 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
                245                 250                 255     


Pro Gly Val Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn 
            260                 265                 270         


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
        275                 280                 285             


Arg Pro Thr Gln Gly Gly Arg Val Ser Ile Ala Leu Ser Ser His Trp 
    290                 295                 300                 


Ile Asn Pro Arg Arg Met Thr Asp Tyr Asn Ile Arg Glu Cys Gln Lys 
305                 310                 315                 320 


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp 
                325                 330                 335     


Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro 
            340                 345                 350         


Asp Phe Thr Glu Ser Glu Lys Arg Leu Ile Arg Gly Thr Ala Asp Phe 
        355                 360                 365             


Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
    370                 375                 380                 


Asn Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Trp Ile Asp Leu Glu Tyr Asn His Pro Pro Ile Phe Ile Val Glu 
                405                 410                 415     


Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr 
            420                 425                 430         


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg 
        435                 440                 445             


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
    450                 455                 460                 


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala 
                485                 490                 495     


Leu Phe Tyr Gln Lys Leu Ile Glu Asp Asn Gly Phe Pro Pro Leu Pro 
            500                 505                 510         


Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly 
        515                 520                 525             


Val Val Asp Asn Tyr Val Gln Val Asp Thr Thr Leu Ser Gln Phe Thr 
    530                 535                 540                 


Asp Pro Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile 
545                 550                 555                 560 


Lys Val Asp Gly Val Val Ala Lys Lys Arg Lys Pro Tyr Cys Val Asp 
                565                 570                 575     


Phe Ser Ala Ile Arg Pro Gln Ile Thr Leu Leu Arg Glu Met Arg Val 
            580                 585                 590         


Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly 
        595                 600                 605             


Asn Gln Thr Gln Val Asn His Thr Val Leu His Phe Tyr Arg Cys Met 
    610                 615                 620                 


Ile Ser Glu Leu Val His Ala Asn Ile Thr Pro Val Val Ala Leu Trp 
625                 630                 635                 640 


Gln Pro Ala Ala Pro His Gln Gly Leu Pro His Ala Leu Ala Lys His 
                645                 650                 655     


Gly Ala Trp Glu Asn Pro His Thr Ala Leu Ala Phe Ala Asp Tyr Ala 
            660                 665                 670         


Asn Leu Cys Phe Lys Glu Leu Gly His Trp Val Asn Leu Trp Ile Thr 
        675                 680                 685             


Met Asn Glu Pro Asn Thr Arg Asn Met Thr Tyr Arg Ala Gly His His 
    690                 695                 700                 


Leu Leu Arg Ala His Ala Leu Ala Trp His Leu Tyr Asp Asp Lys Phe 
705                 710                 715                 720 


Arg Ala Ala Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp 
                725                 730                 735     


Ile Glu Pro Ala Cys Pro Phe Ser Gln Asn Asp Lys Glu Val Ala Glu 
            740                 745                 750         


Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly 
        755                 760                 765             


Ser Gly Asp Tyr Pro Arg Val Met Arg Asp Trp Leu Asn Gln Lys Asn 
    770                 775                 780                 


Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Val Arg 
785                 790                 795                 800 


Gly Ser Phe Asp Phe Leu Ala Val Ser His Tyr Thr Thr Ile Leu Val 
                805                 810                 815     


Asp Trp Glu Lys Glu Asp Pro Met Lys Tyr Asn Asp Tyr Leu Glu Val 
            820                 825                 830         


Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala 
        835                 840                 845             


Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Arg Phe Lys 
    850                 855                 860                 


Tyr Gly Asp Leu Pro Met Tyr Val Thr Ala Asn Gly Ile Asp Asp Asp 
865                 870                 875                 880 


Pro His Ala Glu Gln Asp Ser Leu Arg Ile Tyr Tyr Ile Lys Asn Tyr 
                885                 890                 895     


Val Asn Glu Ala Leu Lys Ala Tyr Val Leu Asp Asp Ile Asn Leu Cys 
            900                 905                 910         


Gly Tyr Phe Ala Tyr Ser Leu Ser Asp Arg Ser Ala Pro Lys Ser Gly 
        915                 920                 925             


Phe Tyr Arg Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys 
    930                 935                 940                 


His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Leu Gly Ser Gly Thr 
945                 950                 955                 960 


Leu Gly Arg Phe Cys Pro Glu Glu Tyr Thr Val Cys Thr Glu Cys Gly 
                965                 970                 975     


Phe Phe Gln Thr Arg Lys Ser Leu Leu Val Phe Ile Ser Phe Leu Val 
            980                 985                 990         


Phe Thr Phe Ile Ile Ser Leu Ala  Leu Ile Phe His Tyr  Ser Lys Lys 
        995                 1000                 1005             


Gly Gln  Arg Ser Tyr Lys 
    1010                 


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker peptide

<400>  13

Ile Glu Gly Arg Asp Met Asp 
1               5           


<210>  14
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His 
545                 


<210>  15
<211>  550
<212>  PRT
<213>  Mus musculus

<400>  15

Met Leu Ala Arg Ala Pro Pro Arg Arg Pro Pro Arg Leu Val Leu Leu 
1               5                   10                  15      


Arg Leu Leu Leu Leu His Leu Leu Leu Leu Ala Leu Arg Ala Arg Cys 
            20                  25                  30          


Leu Ser Ala Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Ala Pro Ala Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro 
    50                  55                  60                  


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Arg Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
                85                  90                  95      


His His Ser Gly Ala Ala Pro Ser Asp Ser Pro Ile Val Val Ala Pro 
            100                 105                 110         


Ser Gly Ala Pro Ser Pro Pro Leu Ser Ser Thr Gly Asp Val Ala Ser 
        115                 120                 125             


Asp Ser Tyr Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
145                 150                 155                 160 


Asn Gly Thr Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly 
        195                 200                 205             


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
    210                 215                 220                 


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
225                 230                 235                 240 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
                245                 250                 255     


Pro Gly Val Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn 
            260                 265                 270         


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
        275                 280                 285             


Arg Pro Thr Gln Gly Gly Arg Val Ser Ile Ala Leu Ser Ser His Trp 
    290                 295                 300                 


Ile Asn Pro Arg Arg Met Thr Asp Tyr Asn Ile Arg Glu Cys Gln Lys 
305                 310                 315                 320 


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp 
                325                 330                 335     


Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro 
            340                 345                 350         


Asp Phe Thr Glu Ser Glu Lys Arg Leu Ile Arg Gly Thr Ala Asp Phe 
        355                 360                 365             


Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
    370                 375                 380                 


Asn Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Trp Ile Asp Leu Glu Tyr Asn His Pro Pro Ile Phe Ile Val Glu 
                405                 410                 415     


Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr 
            420                 425                 430         


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg 
        435                 440                 445             


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
    450                 455                 460                 


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala 
                485                 490                 495     


Leu Phe Tyr Gln Lys Leu Ile Glu Asp Asn Gly Phe Pro Pro Leu Pro 
            500                 505                 510         


Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly 
        515                 520                 525             


Val Val Asp Asn Tyr Val Gln Val Ser Pro Leu Thr Lys Pro Ser Val 
    530                 535                 540                 


Gly Leu Leu Leu Pro His 
545                 550 


<210>  16
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  17
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  17

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  18
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser 
            20              


<210>  19
<211>  3039
<212>  DNA
<213>  Homo sapiens

<400>  19
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtttctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gatacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggctgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaatg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940

tctttactgg ctttcatagc ttttctattt tttgcttcta ttatttctct ctcccttata     3000

ttttactact cgaagaaagg cagaagaagt tacaaatag                            3039


<210>  20
<211>  3045
<212>  DNA
<213>  Mus musculus

<400>  20
atgctagccc gcgcccctcc tcgccgcccg ccgcggctgg tgctgctccg tttgctgttg       60

ctgcatctgc tgctgctcgc cctgcgcgcc cgctgcctga gcgctgagcc gggtcagggc      120

gcgcagacct gggctcgctt cgcgcgcgct cctgccccag aggccgctgg cctcctccac      180

gacaccttcc ccgacggttt cctctgggcg gtaggcagcg ccgcctatca gaccgagggc      240

ggctggcgac agcacggcaa aggcgcgtcc atctgggaca ctttcaccca tcactctggg      300

gcggccccgt ccgactcccc gatcgtcgtg gcgccgtcgg gtgccccgtc gcctcccctg      360

tcctccactg gagatgtggc cagcgatagt tacaacaacg tctaccgcga cacagagggg      420

ctgcgcgaac tgggggtcac ccactaccgc ttctccatat cgtgggcgcg ggtgctcccc      480

aatggcaccg cgggcactcc caaccgcgag gggctgcgct actaccggcg gctgctggag      540

cggctgcggg agctgggcgt gcagccggtg gttaccctgt accattggga cctgccacag      600

cgcctgcagg acacctatgg cggatgggcc aatcgcgccc tggccgacca tttcagggat      660

tatgccgagc tctgcttccg ccacttcggt ggtcaggtca agtactggat caccattgac      720

aacccctacg tggtggcctg gcacgggtat gccaccgggc gcctggcccc gggcgtgagg      780

ggcagctcca ggctcgggta cctggttgcc cacaacctac ttttggctca tgccaaagtc      840

tggcatctct acaacacctc tttccgcccc acacagggag gccgggtgtc tatcgcctta      900

agctcccatt ggatcaatcc tcgaagaatg actgactata atatcagaga atgccagaag      960

tctcttgact ttgtgctagg ctggtttgcc aaacccatat ttattgatgg cgactaccca     1020

gagagtatga agaacaacct ctcgtctctt ctgcctgatt ttactgaatc tgagaagagg     1080

ctcatcagag gaactgctga cttttttgct ctctccttcg gaccaacctt gagctttcag     1140

ctattggacc ctaacatgaa gttccgccaa ttggagtctc ccaacctgag gcagcttctg     1200

tcttggatag atctggaata taaccaccct ccaatattta ttgtggaaaa tggctggttt     1260

gtctcgggaa ccaccaaaag ggatgatgcc aaatatatgt attatctcaa gaagttcata     1320

atggaaacct taaaagcaat cagactggat ggggtcgacg tcattgggta caccgcgtgg     1380

tcgctcatgg acggtttcga gtggcatagg ggctacagca tccggcgagg actcttctac     1440

gttgactttc tgagtcagga caaggagctg ttgccaaagt cttcggcctt gttctaccaa     1500

aagctgatag aggacaatgg ctttcctcct ttacctgaaa accagcccct tgaagggaca     1560

tttccctgtg actttgcttg gggagttgtt gacaactacg ttcaagtgga cactactctc     1620

tctcagttta ctgacccgaa tgtctatctg tgggatgtgc atcacagtaa gaggcttatt     1680

aaagtagacg gggttgtagc caagaagaga aaaccttact gtgttgattt ctctgccatc     1740

cggcctcaga taaccttact tcgagaaatg cgggtcaccc actttcgctt ctccctggac     1800

tgggccctga tcttgcctct gggtaaccag acccaagtga accacacggt tctgcacttc     1860

taccgctgca tgatcagcga gctggtgcac gccaacatca ctccagtggt ggccctgtgg     1920

cagccagcag ccccgcacca aggcctgcca catgcccttg caaaacatgg ggcctgggag     1980

aacccgcaca ctgctctggc gtttgcagac tacgcaaacc tgtgttttaa agagttgggt     2040

cactgggtca atctctggat caccatgaac gagccaaaca cacggaacat gacctatcgt     2100

gccgggcacc acctcctgag agcccatgcc ttggcttggc atctgtacga tgacaagttt     2160

agggcggctc agaaaggcaa aatatccatc gccttgcagg ctgactggat agaaccggcc     2220

tgccctttct ctcaaaatga caaagaagtg gccgagagag ttttggaatt tgatataggc     2280

tggctggcag agcctatttt tggttccgga gattatccac gtgtgatgag ggactggctg     2340

aaccaaaaaa acaattttct tttgccctat ttcaccgaag atgaaaaaaa gctagtccgg     2400

ggttcctttg acttcctggc ggtgagtcat tacaccacca ttctggtaga ctgggaaaag     2460

gaggatccga tgaaatacaa cgattacttg gaggtacagg agatgactga catcacatgg     2520

ctcaactctc ccagtcaggt ggcagtggtg ccttgggggc tgcgcaaagt gctcaactgg     2580

ctaaggttca agtacggaga cctcccgatg tatgtgacag ccaatggaat cgatgatgac     2640

ccccacgccg agcaagactc actgaggatc tattatatta agaattatgt gaatgaggct     2700

ctgaaagcct acgtgttgga cgacatcaac ctttgtggct actttgcgta ttcacttagt     2760

gatcgctcag ctcccaagtc tggcttttat cgatatgctg cgaatcagtt tgagcccaaa     2820

ccatctatga aacattacag gaaaattatt gacagcaatg gcttcctggg ttctggaaca     2880

ctgggaaggt tttgtccaga agaatacact gtgtgcaccg aatgtggatt ttttcaaacc     2940

cggaagtctt tgctggtctt catctcgttt cttgttttta cttttattat ttctcttgct     3000

ctcatttttc actactccaa gaaaggccag agaagttata agtaa                     3045


<210>  21
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Gly Thr Gly Arg Ile Pro His Leu Thr Cys Asp Ser Leu Thr Pro Ala 
        355                 360                 365             


Gly Arg Thr Lys Ser Pro Thr Leu Gln Phe Ser Leu Glu Ser Gly Ser 
    370                 375                 380                 


Ser Gly Lys Ser Ser Ser Ser Leu Val Arg Gly Val Arg Leu Ser Ser 
385                 390                 395                 400 


Ser Gly Pro Ala Leu Leu Ala Gly Leu Val Ser Leu Asp Leu Pro Leu 
                405                 410                 415     


Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu Val Leu Gly Lys Pro 
            420                 425                 430         


Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg Ala Glu Ala Phe Gly 
        435                 440                 445             


Met Asp Pro Ala Arg Pro Asp Gln Ala Ser Thr Val Ala Val Lys Met 
    450                 455                 460                 


Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ile Glu Gly Arg Asp Met 
465                 470                 475                 480 


Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                485                 490                 495     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            500                 505                 510         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        515                 520                 525             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    530                 535                 540                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
545                 550                 555                 560 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                565                 570                 575     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            580                 585                 590         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        595                 600                 605             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    610                 615                 620                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
625                 630                 635                 640 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                645                 650                 655     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            660                 665                 670         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        675                 680                 685             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    690                 695                 700                 


Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710         


