                         SEQUENCE LISTING

<110>  City of Hope
       Burnett, John
       Pham, Anh
 
<120>  Cationic Compounds for Delivery of Nucleic Acids

<130>  048440-680001WO

<150>  US 62/726,004
<151>  2018-08-31

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy3

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  modified_base
<222>  (2)..(3)
<223>  gm

<220>
<221>  misc_feature
<222>  (4)..(39)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  um

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  um

<400>  1
uggggggugu cuuugggguu guuuuagagc uaugcuguuu ug                          42


<210>  2
<211>  39
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy3

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  modified_base
<222>  (2)..(3)
<223>  2'-O methyladenosine

<220>
<221>  misc_feature
<222>  (4)..(36)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (37)..(39)
<223>  gm

<400>  2
uaauuucuac ucuuguagau ggguuugguu gguucgggg                              39


<210>  3
<211>  39
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (37)..(39)
<223>  gm

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  3' Cy3

<400>  3
uaauuucuac ucuuguagau ggguuugguu gguucgggg                              39


<210>  4
<211>  39
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (5)..(8)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  cm

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  cm

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  cm

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  um

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  gm

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O methyladenosine

<220>
<221>  misc_feature
<222>  (20)..(37)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (38)..(39)
<223>  gm

<400>  4
uaauuucuac ucuuguagau ggguuugguu gguucgggg                              39


<210>  5
<211>  41
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  cm

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  um

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  cm

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  cm

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  um

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  gm

<220>
<221>  misc_feature
<222>  (20)..(38)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  um

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-O methyladenosine

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  3' Cy3

<400>  5
uaauuucuac ucuuguagau ggguuugguu gguucggggu a                           41


<210>  6
<211>  36
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy3

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  gm

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  gm

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  um

<220>
<221>  misc_feature
<222>  (5)..(26)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  um

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  gm

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  cm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  um

<400>  6
gagugguuag uuuuauuagg guuuuagagc uaugcu                                 36


<210>  7
<211>  67
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O methyladenosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bond

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate bond

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  um

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  gm

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  cm

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  um

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  cm

<220>
<221>  modified_base
<222>  (36)..(37)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  cm

<220>
<221>  modified_base
<222>  (39)..(40)
<223>  um

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  gm

<220>
<221>  modified_base
<222>  (42)..(46)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (47)..(47)
<223>  gm

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  um

<220>
<221>  modified_base
<222>  (49)..(50)
<223>  gm

<220>
<221>  modified_base
<222>  (51)..(51)
<223>  cm

<220>
<221>  modified_base
<222>  (52)..(52)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (53)..(54)
<223>  cm

<220>
<221>  modified_base
<222>  (55)..(55)
<223>  gm

<220>
<221>  modified_base
<222>  (56)..(56)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (57)..(57)
<223>  gm

<220>
<221>  modified_base
<222>  (58)..(58)
<223>  um

<220>
<221>  modified_base
<222>  (59)..(59)
<223>  cm

<220>
<221>  modified_base
<222>  (60)..(61)
<223>  gm

<220>
<221>  modified_base
<222>  (62)..(62)
<223>  um

<220>
<221>  modified_base
<222>  (64)..(64)
<223>  cm

<220>
<221>  modified_base
<222>  (65)..(67)
<223>  um

<220>
<221>  misc_feature
<222>  (65)..(66)
<223>  phosphorothioate bond

<220>
<221>  misc_feature
<222>  (66)..(67)
<223>  phosphorothioate bond

<400>  7
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210>  8
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy5

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  3' Cy3

<400>  8
taatttctac tcttgtagat gggtttggtt ggttcggggt a                           41


<210>  9
<211>  67
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy5

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  um

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  gm

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  cm

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O methyladenosine

<220>
<221>  misc_feature
<222>  (10)..(37)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (38)..(38)
<223>  cm

<220>
<221>  modified_base
<222>  (39)..(40)
<223>  um

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  gm

<220>
<221>  modified_base
<222>  (42)..(46)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (47)..(47)
<223>  gm

<220>
<221>  modified_base
<222>  (48)..(48)
<223>  um

<220>
<221>  modified_base
<222>  (49)..(50)
<223>  gm

<220>
<221>  modified_base
<222>  (51)..(51)
<223>  cm

<220>
<221>  modified_base
<222>  (52)..(52)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (53)..(54)
<223>  cm

<220>
<221>  modified_base
<222>  (55)..(55)
<223>  gm

<220>
<221>  modified_base
<222>  (56)..(56)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (57)..(57)
<223>  gm

<220>
<221>  modified_base
<222>  (58)..(58)
<223>  um

<220>
<221>  modified_base
<222>  (59)..(59)
<223>  cm

<220>
<221>  modified_base
<222>  (60)..(61)
<223>  gm

<220>
<221>  modified_base
<222>  (62)..(62)
<223>  um

<220>
<221>  modified_base
<222>  (63)..(63)
<223>  gm

<220>
<221>  modified_base
<222>  (64)..(64)
<223>  cm

<220>
<221>  modified_base
<222>  (65)..(67)
<223>  um

<400>  9
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210>  10
<211>  41
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy5

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (5)..(8)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  cm

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  cm

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  cm

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  um

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  gm

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O methyladenosine

<220>
<221>  misc_feature
<222>  (20)..(38)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  um

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-O methyladenosine

<400>  10
uaauuucuac ucuuguagau ggguuugguu gguucggggu a                           41


<210>  11
<211>  56
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy5

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  gm

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  um

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (4)..(7)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  gm

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  cm

<220>
<221>  modified_base
<222>  (12)..(16)
<223>  um

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  um

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  cm

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  um

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  cm

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  cm

<220>
<221>  modified_base
<222>  (28)..(29)
<223>  um

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  gm

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O methyladenosine

<220>
<221>  misc_feature
<222>  (35)..(53)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (54)..(54)
<223>  gm

<220>
<221>  modified_base
<222>  (55)..(55)
<223>  um

<220>
<221>  modified_base
<222>  (56)..(56)
<223>  2'-O methyladenosine

<400>  11
gucaaaagac cuuuuuaauu ucuacucuug uagauggguu ugguugguuc ggggua           56


<210>  12
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy3

<400>  12
taatttctac tcttgtagat gggtttggtt ggttcggggt a                           41


<210>  13
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  3' Cy3

<400>  13
taatttctac tcttgtagat gggtttggtt ggttcggggt a                           41


<210>  14
<211>  67
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy5

<400>  14
agcatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg       60

gtgcttt                                                                 67


<210>  15
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' ATTO247n

<400>  15
taatttctac tcttgtagat gggtttggtt ggttcggggt a                           41


<210>  16
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  3' Cy3

<400>  16
taatttctac tcttgtagat gggtttggtt ggttcggggt a                           41


<210>  17
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' AmMC6

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  3' Cy3

<400>  17
taatttctac tcttgtagat gggtttggtt ggttcggggt a                           41


<210>  18
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5dSp

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  3' Cy3

<400>  18
taatttctac tcttgtagat gggtttggtt ggttcggggt a                           41


<210>  19
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  19

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  20
<211>  90
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy5

<400>  20
gctgctaacc ccataccccg aaccaaccaa accccaaaga caatgggcaa gcccatcccc       60

aaccccttgc ttggcttgga cagcacctaa                                        90


<210>  21
<211>  90
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy3

<400>  21
ttaggtgctg tccaagccaa gcaaggggtt ggggatgggc ttgcccattg tctttggggt       60

ttggttggtt cggggtatgg ggttagcagc                                        90


<210>  22
<211>  41
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy5

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  unmodified RNA nucleotide

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  cm

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  um

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  cm

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  unmodified RNA nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  cm

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  um

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  unmodified RNA nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  gm

<220>
<221>  misc_feature
<222>  (20)..(38)
<223>  unmodified RNA nucleotide

<220>
<221>  modified_base
<222>  (39)..(41)
<223>  um

<400>  22
uaauuucuac ucuuguagau ucuuuuggcg guaugcacuu u                           41


<210>  23
<211>  36
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Cy3

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  um

<220>
<221>  misc_feature
<222>  (5)..(26)
<223>  unmodified RNA nucleotide

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  um

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  gm

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  cm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  um

<400>  23
aauuugaaau cugguuaggc guuuuagagc uaugcu                                 36


<210>  24
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu 
            20                  25  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu 
            20                  25                  


<210>  26
<211>  87
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
atgtccgtcc tgacgccgct gctgctgcgg ggcttgacag gctcggcccg gcggctccca       60

gtgccgcgcg ccaagatcca ttcgttg                                           87


<210>  27
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
acctgactga ctacctcatg aagatcctca ccga                                   34


<210>  28
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
ggagctggaa gcagccgtgg ccatctcttg ctcgaa                                 36


<210>  29
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-Cy5

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  black hole quencher

<400>  29
agcgggaaat cgtgcgtgac attaagg                                           27


<210>  30
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
gcctatatta cggatcattt ctctact                                           27


<210>  31
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
gcctatgaag gctgttgcta tagt                                              24


<210>  32
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-HEX

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  black hole quencher

<400>  32
cctgaaacat cggcattatc ctcctgct                                          28


<210>  33
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
ggcccgttgt caggcaacgt gg                                                22


<210>  34
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
ggaaaggagc tgacaggtgg tggcaatg                                          28


<210>  35
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-FAM

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  black hole quencher

<400>  35
tgctgacgca acccccactg gt                                                22


<210>  36
<211>  36
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Cy3

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  modified_base
<222>  (2)..(4)
<223>  2'-O-Methyladenosine

<220>
<221>  misc_feature
<222>  (5)..(26)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-Methyladenosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-Methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  um

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  gm

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  cm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  um

<400>  36
uaaacugugg ggggugucuu guuuuagagc uaugcu                                 36


<210>  37
<211>  36
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Cy3

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  gm

<220>
<221>  modified_base
<222>  (2)..(3)
<223>  2'-O-Methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  gm

<220>
<221>  misc_feature
<222>  (5)..(26)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(28)
<223>  2'-O-Methyladenosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  gm

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  cm

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  um

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-Methyladenosine

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  um

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  gm

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  cm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  um

<400>  37
gaagcgugau gacaaagagg guuuuagagc uaugcu                                 36


<210>  38
<211>  41
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Cy5

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (5)..(8)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  cm

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-Methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  cm

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  cm

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  um

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-Methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  gm

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-Methyladenosine

<220>
<221>  misc_feature
<222>  (20)..(38)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (39)..(40)
<223>  2'-O-Methyladenosine

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  cm

<400>  38
uaauuucuac ucuuguagau cagauauaca cuucagauaa c                           41


<210>  39
<211>  41
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'Cy5

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (5)..(8)
<223>  um

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  cm

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  um

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-Methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  cm

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  cm

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  um

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-Methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  gm

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-Methyladenosine

<220>
<221>  misc_feature
<222>  (20)..(38)
<223>  ribonucleotide

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  gm

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  um

<220>
<221>  modified_base
<222>  (41)..(41)
<223>  2'-O-Methyladenosine

<400>  39
uaauuucuac ucuuguagau ggguuugguu gguucggggu a                           41


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
gcacagccac tttccacaca g                                                 21


<210>  41
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
gggagtggga ggggaaaata atg                                               23


<210>  42
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-FAM

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  black hole quencher

<400>  42
caaagaaccc taacaccagc ctaaccag                                          28


<210>  43
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
catcctaccc agcacacaca cac                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
cggggatgct tgcatgtgta atc                                               23


<210>  45
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-FAM

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  black hole quencher

<400>  45
caaccaaacc ccaaagacac cccccac                                           27


<210>  46
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Asn Gly Gly 
1           


<210>  47
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Asn Gly Arg Arg Thr 
1               5   


<210>  48
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Asn Gly Arg Arg Asn 
1               5   


<210>  49
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Asn Asn Asn Asn Gly Ala Thr Thr 
1               5               


<210>  50
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Asn Asn Ala Gly Ala Ala Trp 
1               5           


<210>  51
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Asn Ala Ala Ala Ala Cys 
1               5       


<210>  52
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Thr Thr Asn 
1           


<210>  53
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Asn Gly Gly 
1           


<210>  54
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  54

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Phe Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Ile  Tyr Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  55
<211>  1388
<212>  PRT
<213>  Streptococcus pyogenes

<400>  55

Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Lys Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Thr Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


