                              SEQUENCE LISTING

<110> HCW BIOLOGICS, INC.
 
<120> METHODS OF TREATING AGING-RELATED DISORDER

<130> 47039-0013WO1

<140>
<141>

<150> 62/881,088 
<151> 2019-07-31

<150> 62/881,039
<151> 2019-07-31

<150> 62/817,244 
<151> 2019-03-12

<150> 62/817,241
<151> 2019-03-12

<150> 62/817,230 
<151> 2019-03-12

<150> 62/816,683
<151> 2019-03-11

<150> 62/749,506 
<151> 2018-10-23

<150> 62/749,007 
<151> 2018-10-22

<150> 62/746,832 
<151> 2018-10-17

<150> 62/725,043 
<151> 2018-08-30

<150> 62/725,038 
<151> 2018-08-30

<150> 62/725,010
<151> 2018-08-30

<150> 62/724,969
<151> 2018-08-30

<160> 334   

<170> PatentIn version 3.5

<210> 1
<211> 251
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD25"

<400> 1
Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly 
    210                 215                 220                 


Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp 
225                 230                 235                 240 


Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                245                 250     


<210> 2
<211> 753
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD25"

<400> 2
gagctctgtg acgatgaccc gccagagatc ccacacgcca cattcaaagc catggcctac       60

aaggaaggaa ccatgttgaa ctgtgaatgc aagagaggtt tccgcagaat aaaaagcggg      120

tcactctata tgctctgtac aggaaactct agccactcgt cctgggacaa ccaatgtcaa      180

tgcacaagct ctgccactcg gaacacaacg aaacaagtga cacctcaacc tgaagaacag      240

aaagaaagga aaaccacaga aatgcaaagt ccaatgcagc cagtggacca agcgagcctt      300

ccaggtcact gcagggaacc tccaccatgg gaaaatgaag ccacagagag aatttatcat      360

ttcgtggtgg ggcagatggt ttattatcag tgcgtccagg gatacagggc tctacacaga      420

ggtcctgctg agagcgtctg caaaatgacc cacgggaaga caaggtggac ccagccccag      480

ctcatatgca caggtgaaat ggagaccagt cagtttccag gtgaagagaa gcctcaggca      540

agccccgaag gccgtcctga gagtgagact tcctgcctcg tcacaacaac agattttcaa      600

atacagacag aaatggctgc aaccatggag acgtccatat ttacaacaga gtaccaggta      660

gcagtggccg gctgtgtttt cctgctgatc agcgtcctcc tcctgagtgg gctcacctgg      720

cagcggagac agaggaagag tagaagaaca atc                                   753


<210> 3
<211> 199
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD69"

<400> 3
Met Ser Ser Glu Asn Cys Phe Val Ala Glu Asn Ser Ser Leu His Pro 
1               5                   10                  15      


Glu Ser Gly Gln Glu Asn Asp Ala Thr Ser Pro His Phe Ser Thr Arg 
            20                  25                  30          


His Glu Gly Ser Phe Gln Val Pro Val Leu Cys Ala Val Met Asn Val 
        35                  40                  45              


Val Phe Ile Thr Ile Leu Ile Ile Ala Leu Ile Ala Leu Ser Val Gly 
    50                  55                  60                  


Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Ser Asp Ser 
65                  70                  75                  80  


His Val Ser Ser Cys Ser Glu Asp Trp Val Gly Tyr Gln Arg Lys Cys 
                85                  90                  95      


Tyr Phe Ile Ser Thr Val Lys Arg Ser Trp Thr Ser Ala Gln Asn Ala 
            100                 105                 110         


Cys Ser Glu His Gly Ala Thr Leu Ala Val Ile Asp Ser Glu Lys Asp 
        115                 120                 125             


Met Asn Phe Leu Lys Arg Tyr Ala Gly Arg Glu Glu His Trp Val Gly 
    130                 135                 140                 


Leu Lys Lys Glu Pro Gly His Pro Trp Lys Trp Ser Asn Gly Lys Glu 
145                 150                 155                 160 


Phe Asn Asn Trp Phe Asn Val Thr Gly Ser Asp Lys Cys Val Phe Leu 
                165                 170                 175     


Lys Asn Thr Glu Val Ser Ser Met Glu Cys Glu Lys Asn Leu Tyr Trp 
            180                 185                 190         


Ile Cys Asn Lys Pro Tyr Lys 
        195                 


<210> 4
<211> 600
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD69"

<400> 4
atgagctctg aaaattgttt cgtagcagag aacagctctt tgcatccgga gagtggacaa       60

gaaaatgatg ccaccagtcc ccatttctca acacgtcatg aagggtcctt ccaagttcct      120

gtcctgtgtg ctgtaatgaa tgtggtcttc atcaccattt taatcatagc tctcattgcc      180

ttatcagtgg gccaatacaa ttgtccaggc caatacacat tctcaatgcc atcagacagc      240

catgtttctt catgctctga ggactgggtt ggctaccaga ggaaatgcta ctttatttct      300

actgtgaaga ggagctggac ttcagcccaa aatgcttgtt ctgaacatgg tgctactctt      360

gctgtcattg attctgaaaa ggacatgaac tttctaaaac gatacgcagg tagagaggaa      420

cactgggttg gactgaaaaa ggaacctggt cacccatgga agtggtcaaa tggcaaagaa      480

tttaacaact ggttcaacgt tacagggtct gacaagtgtg tttttctgaa aaacacagag      540

gtcagcagca tggaatgtga gaagaattta tactggatat gtaacaaacc ttacaaataa      600


<210> 5
<211> 77
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="CD59"

<400> 5
Leu Gln Cys Tyr Asn Cys Pro Asn Pro Thr Ala Asp Cys Lys Thr Ala 
1               5                   10                  15      


Val Asn Cys Ser Ser Asp Phe Asp Ala Cys Leu Ile Thr Lys Ala Gly 
            20                  25                  30          


Leu Gln Val Tyr Asn Lys Cys Trp Lys Phe Glu His Cys Asn Phe Asn 
        35                  40                  45              


Asp Val Thr Thr Arg Leu Arg Glu Asn Glu Leu Thr Tyr Tyr Cys Cys 
    50                  55                  60                  


Lys Lys Asp Leu Cys Asn Phe Asn Glu Gln Leu Glu Asn 
65                  70                  75          


<210> 6
<211> 387
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="CD59"

<400> 6
atgggaatcc aaggagggtc tgtcctgttc gggctgctgc tcgtcctggc tgtcttctgc       60

cattcaggtc atagcctgca gtgctacaac tgtcctaacc caactgctga ctgcaaaaca      120

gccgtcaatt gttcatctga ttttgatgcg tgtctcatta ccaaagctgg gttacaagtg      180

tataacaagt gttggaagtt tgagcattgc aatttcaacg acgtcacaac ccgcttgagg      240

gaaaatgagc taacgtacta ctgctgcaag aaggacctgt gtaactttaa cgaacagctt      300

gaaaatggtg ggacatcctt atcagagaaa acagttcttc tgctggtgac tccatttctg      360

gcagcagcct ggagccttca tccctaa                                          387


<210> 7
<211> 311
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD352"

<400> 7
Gln Ser Ser Leu Thr Pro Leu Met Val Asn Gly Ile Leu Gly Glu Ser 
1               5                   10                  15      


Val Thr Leu Pro Leu Glu Phe Pro Ala Gly Glu Lys Val Asn Phe Ile 
            20                  25                  30          


Thr Trp Leu Phe Asn Glu Thr Ser Leu Ala Phe Ile Val Pro His Glu 
        35                  40                  45              


Thr Lys Ser Pro Glu Ile His Val Thr Asn Pro Lys Gln Gly Lys Arg 
    50                  55                  60                  


Leu Asn Phe Thr Gln Ser Tyr Ser Leu Gln Leu Ser Asn Leu Lys Met 
65                  70                  75                  80  


Glu Asp Thr Gly Ser Tyr Arg Ala Gln Ile Ser Thr Lys Thr Ser Ala 
                85                  90                  95      


Lys Leu Ser Ser Tyr Thr Leu Arg Ile Leu Arg Gln Leu Arg Asn Ile 
            100                 105                 110         


Gln Val Thr Asn His Ser Gln Leu Phe Gln Asn Met Thr Cys Glu Leu 
        115                 120                 125             


His Leu Thr Cys Ser Val Glu Asp Ala Asp Asp Asn Val Ser Phe Arg 
    130                 135                 140                 


Trp Glu Ala Leu Gly Asn Thr Leu Ser Ser Gln Pro Asn Leu Thr Val 
145                 150                 155                 160 


Ser Trp Asp Pro Arg Ile Ser Ser Glu Gln Asp Tyr Thr Cys Ile Ala 
                165                 170                 175     


Glu Asn Ala Val Ser Asn Leu Ser Phe Ser Val Ser Ala Gln Lys Leu 
            180                 185                 190         


Cys Glu Asp Val Lys Ile Gln Tyr Thr Asp Thr Lys Met Ile Leu Phe 
        195                 200                 205             


Met Val Ser Gly Ile Cys Ile Val Phe Gly Phe Ile Ile Leu Leu Leu 
    210                 215                 220                 


Leu Val Leu Arg Lys Arg Arg Asp Ser Leu Ser Leu Ser Thr Gln Arg 
225                 230                 235                 240 


Thr Gln Gly Pro Ala Glu Ser Ala Arg Asn Leu Glu Tyr Val Ser Val 
                245                 250                 255     


Ser Pro Thr Asn Asn Thr Val Tyr Ala Ser Val Thr His Ser Asn Arg 
            260                 265                 270         


Glu Thr Glu Ile Trp Thr Pro Arg Glu Asn Asp Thr Ile Thr Ile Tyr 
        275                 280                 285             


Ser Thr Ile Asn His Ser Lys Glu Ser Lys Pro Thr Phe Ser Arg Ala 
    290                 295                 300                 


Thr Ala Leu Asp Asn Val Val 
305                 310     


<210> 8
<211> 996
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD59"

<400> 8
atgttgtggc tgttccaatc gctcctgttt gtcttctgct ttggcccagg gaatgtagtt       60

tcacaaagca gcttaacccc attgatggtg aacgggattc tgggggagtc agtaactctt      120

cccctggagt ttcctgcagg agagaaggtc aacttcatca cttggctttt caatgaaaca      180

tctcttgcct tcatagtacc ccatgaaacc aaaagtccag aaatccacgt gactaatccg      240

aaacagggaa agcgactgaa cttcacccag tcctactccc tgcaactcag caacctgaag      300

atggaagaca caggctctta cagagcccag atatccacaa agacctctgc aaagctgtcc      360

agttacactc tgaggatatt aagacaactg aggaacatac aagttaccaa tcacagtcag      420

ctatttcaga atatgacctg tgagctccat ctgacttgct ctgtggagga tgcagatgac      480

aatgtctcat tcagatggga ggccttggga aacacacttt caagtcagcc aaacctcact      540

gtctcctggg accccaggat ttccagtgaa caggactaca cctgcatagc agagaatgct      600

gtcagtaatt tatccttctc tgtctctgcc cagaagcttt gcgaagatgt taaaattcaa      660

tatacagata ccaaaatgat tctgtttatg gtttctggga tatgcatagt cttcggtttc      720

atcatactgc tgttacttgt tttgaggaaa agaagagatt ccctatcttt gtctactcag      780

cgaacacagg gccccgagtc cgcaaggaac ctagagtatg tttcagtgtc tccaacgaac      840

aacactgtgt atgcttcagt cactcattca aacagggaaa cagaaatctg gacacctaga      900

gaaaatgata ctatcacaat ttactccaca attaatcatt ccaaagagag taaacccact      960

ttttccaggg caactgccct tgacaatgtc gtgtaa                                996


<210> 9
<211> 231
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="NKp80"

<400> 9
Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn Val Gln Ser Lys Lys 
1               5                   10                  15      


Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser Val 
            20                  25                  30          


Thr Leu His Trp Tyr Lys Ile Leu Leu Gly Ile Ser Gly Thr Val Asn 
        35                  40                  45              


Gly Ile Leu Thr Leu Thr Leu Ile Ser Leu Ile Leu Leu Val Ser Gln 
    50                  55                  60                  


Gly Val Leu Leu Lys Cys Gln Lys Gly Ser Cys Ser Asn Ala Thr Gln 
65                  70                  75                  80  


Tyr Glu Asp Thr Gly Asp Leu Lys Val Asn Asn Gly Thr Arg Arg Asn 
                85                  90                  95      


Ile Ser Asn Lys Asp Leu Cys Ala Ser Arg Ser Ala Asp Gln Thr Val 
            100                 105                 110         


Leu Cys Gln Ser Glu Trp Leu Lys Tyr Gln Gly Lys Cys Tyr Trp Phe 
        115                 120                 125             


Ser Asn Glu Met Lys Ser Trp Ser Asp Ser Tyr Val Tyr Cys Leu Glu 
    130                 135                 140                 


Arg Lys Ser His Leu Leu Ile Ile His Asp Gln Leu Glu Met Ala Phe 
145                 150                 155                 160 


Ile Gln Lys Asn Leu Arg Gln Leu Asn Tyr Val Trp Ile Gly Leu Asn 
                165                 170                 175     


Phe Thr Ser Leu Lys Met Thr Trp Thr Trp Val Asp Gly Ser Pro Ile 
            180                 185                 190         


Asp Ser Lys Ile Phe Phe Ile Lys Gly Pro Ala Lys Glu Asn Ser Cys 
        195                 200                 205             


Ala Ala Ile Lys Glu Ser Lys Ile Phe Ser Glu Thr Cys Ser Ser Val 
    210                 215                 220                 


Phe Lys Trp Ile Cys Gln Tyr 
225                 230     


<210> 10
<211> 546
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Npk80"

<400> 10
atgcaagatg aagaaagata catgacattg aatgtacagt caaagaaaag gagttctgcc       60

caaacatctc aacttacatt taaagattat tcagtgacgt tgcactggta taaaatctta      120

ctgggaatat ctggaaccgt gaatggtatt ctcactttga ctttgatctc cttgatcctg      180

ttggtactat gccaatcaga atggctcaaa taccaaggga agtgttattg gttctctaat      240

gagatgaaaa gctggagtga cagttatgtg tattgtttgg aaagaaaatc tcatctacta      300

atcatacatg accaacttga aatggctttt atacagaaaa acctaagaca attaaactac      360

gtatggattg ggcttaactt tacctccttg aaaatgacat ggacttgggt ggatggttct      420

ccaatagatt caaagatatt cttcataaag ggaccagcta aagaaaacag ctgtgctgcc      480

attaaggaaa gcaaaatttt ctctgaaacc tgcagcagtg ttttcaaatg gatttgtcag      540

tattag                                                                 546


<210> 11
<211> 318
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="DNAM-1"

<400> 11
Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn Met Ser 
1               5                   10                  15      


Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val Glu Trp 
            20                  25                  30          


Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser Pro Thr 
        35                  40                  45              


His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr Phe Leu 
    50                  55                  60                  


Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg Asn Ala 
65                  70                  75                  80  


Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr Tyr Pro 
                85                  90                  95      


Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp Ser Phe 
            100                 105                 110         


Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro Gly Lys 
        115                 120                 125             


Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val Gln Ala 
    130                 135                 140                 


Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu Thr Tyr 
145                 150                 155                 160 


Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro Arg Gln 
                165                 170                 175     


Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val Ile Pro 
            180                 185                 190         


Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu Gln Ala 
        195                 200                 205             


Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val Ala Glu 
    210                 215                 220                 


Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly Thr Val 
225                 230                 235                 240 


Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val Ile Phe 
                245                 250                 255     


Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr Glu Ser 
            260                 265                 270         


Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile Ser Thr 
        275                 280                 285             


Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp Ile Tyr 
    290                 295                 300                 


Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
305                 310                 315             


<210> 12
<211> 1011
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="DNAM-1"

<400> 12
atggattatc ctactttact tttggctctt cttcatgtat acagagctct atgtgaagag       60

gtgctttggc atacatcagt tccctttgcc gagaacatgt ctctagaatg tgtgtatcca      120

tcaatgggca tcttaacaca ggtggagtgg ttcaagatcg ggacccagca ggattccata      180

gccattttca gccctactca tggcatggtc ataaggaagc cctatgctga gagggtttac      240

tttttgaatt caacgatggc ttccaataac atgactcttt tctttcggaa tgcctctgaa      300

gatgatgttg gctactattc ctgctctctt tacacttacc cacagggaac ttggcagaag      360

gtgatacagg tggttcagtc agatagtttt gaggcagctg tgccatcaaa tagccacatt      420

gtttcggaac ctggaaagaa tgtcacactc acttgtcagc ctcagatgac gtggcctgtg      480

caggcagtga ggtgggaaaa gatccagccc cgtcagatcg acctcttaac ttactgcaac      540

ttggtccatg gcagaaattt cacctccaag ttcccaagac aaatagtgag caactgcagc      600

cacggaaggt ggagcgtcat cgtcatcccc gatgtcacag tctcagactc ggggctttac      660

cgctgctact tgcaggccag cgcaggagaa aacgaaacct tcgtgatgag attgactgta      720

gccgagggta aaaccgataa ccaatatacc ctctttgtgg ctggagggac agttttattg      780

ttgttgtttg ttatctcaat taccaccatc attgtcattt tccttaacag aaggagaagg      840

agagagagaa gagatctatt tacagagtcc tgggatacac agaaggcacc caataactat      900

agaagtccca tctctaccag tcaacctacc aatcaatcca tggatgatac aagagaggat      960

atttatgtca actatccaac cttctctcgc agaccaaaga ctagagttta a              1011


<210> 13
<211> 347
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="HB4"

<400> 13
Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile Ser Gly 
1               5                   10                  15      


Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val Asp Ser 
            20                  25                  30          


Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His His Ile 
        35                  40                  45              


Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn Asp Arg 
    50                  55                  60                  


Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala Ala Gln 
65                  70                  75                  80  


Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile Ser Gly 
                85                  90                  95      


Lys Val Gln Thr Ala Thr Phe Gln Val Phe Val Phe Asp Lys Val Glu 
            100                 105                 110         


Lys Pro Arg Leu Gln Gly Gln Gly Lys Ile Leu Asp Arg Gly Arg Cys 
        115                 120                 125             


Gln Val Ala Leu Ser Cys Leu Val Ser Arg Asp Gly Asn Val Ser Tyr 
    130                 135                 140                 


Ala Trp Tyr Arg Gly Ser Lys Leu Ile Gln Thr Ala Gly Asn Leu Thr 
145                 150                 155                 160 


Tyr Leu Asp Glu Glu Val Asp Ile Asn Gly Thr His Thr Tyr Thr Cys 
                165                 170                 175     


Asn Val Ser Asn Pro Val Ser Trp Glu Ser His Thr Leu Asn Leu Thr 
            180                 185                 190         


Gln Asp Cys Gln Asn Ala His Gln Glu Phe Arg Phe Trp Pro Phe Leu 
        195                 200                 205             


Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu Ala Cys 
    210                 215                 220                 


Phe Cys Val Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser 
225                 230                 235                 240 


Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr 
                245                 250                 255     


Arg Arg Asn His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr 
            260                 265                 270         


Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu 
        275                 280                 285             


Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly 
    290                 295                 300                 


Ser Arg Lys Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu 
305                 310                 315                 320 


Val Ile Gly Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser 
                325                 330                 335     


Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr Ser 
            340                 345         


<210> 14
<211> 1098
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="HB4"

<400> 14
atgctggggc aagtggtcac cctcatactc ctcctgctcc tcaaggtgta tcagggcaaa       60

ggatgccagg gatcagctga ccatgtggtt agcatctcgg gagtgcctct tcagttacaa      120

ccaaacagca tacagacgaa ggttgacagc attgcatgga agaagttgct gccctcacaa      180

aatggatttc atcacatatt gaagtgggag aatggctctt tgccttccaa tacttccaat      240

gatagattca gttttatagt caagaacttg agtcttctca tcaaggcagc tcagcagcag      300

gacagtggcc tctactgcct ggaggtcacc agtatatctg gaaaagttca gacagccacg      360

ttccaggttt ttgtatttga taaagttgag aaaccccgcc tacaggggca ggggaagatc      420

ctggacagag ggagatgcca agtggctctg tcttgcttgg tctccaggga tggcaatgtg      480

tcctatgctt ggtacagagg gagcaagctg atccagacag cagggaacct cacctacctg      540

gacgaggagg ttgacattaa tggcactcac acatatacct gcaatgtcag caatcctgtt      600

agctgggaaa gccacaccct gaatctcact caggactgtc agaatgccca tcaggaattc      660

agattttggc cgtttttggt gatcatcgtg attctaagcg cactgttcct tggcaccctt      720

gcctgcttct gtgtgtggag gagaaagagg aaggagaagc agtcagagac cagtcccaag      780

gaatttttga caatttacga agatgtcaag gatctgaaaa ccaggagaaa tcacgagcag      840

gagcagactt ttcctggagg ggggagcacc atctactcta tgatccagtc ccagtcttct      900

gctcccacgt cacaagaacc tgcatataca ttatattcat taattcagcc ttccaggaag      960

tctggatcca ggaagaggaa ccacagccct tccttcaata gcactatcta tgaagtgatt     1020

ggaaagagtc aacctaaagc ccagaaccct gctcgattga gccgcaaaga gctggagaac     1080

tttgatgttt attcctag                                                   1098


<210> 15
<211> 183
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="NK-p30"

<400> 15
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe 
        115                 120                 125             


Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val Tyr Tyr 
    130                 135                 140                 


Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu Pro Ala 
145                 150                 155                 160 


Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala His Leu 
                165                 170                 175     


Leu Pro Pro Val Pro Gly Gly 
            180             


<210> 16
<211> 573
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="NKp30"

<400> 16
atggcctgga tgctgttgct catcttgatc atggtccatc caggatcctg tgctctctgg       60

gtgtcccagc cccctgagat tcgtaccctg gaaggatcct ctgccttcct gccctgctcc      120

ttcaatgcca gccaagggag actggccatt ggctccgtca cgtggttccg agatgaggtg      180

gttccaggga aggaggtgag gaatggaacc ccagagttca ggggccgcct ggccccactt      240

gcttcttccc gtttcctcca tgaccaccag gctgagctgc acatccggga cgtgcgaggc      300

catgacgcca gcatctacgt gtgcagagtg gaggtgctgg gccttggtgt cgggacaggg      360

aatgggactc ggctggtggt ggagaaagaa catcctcagc taggggctgg tacagtcctc      420

ctccttcggg ctggattcta tgctgtcagc tttctctctg tggccgtggg cagcaccgtc      480

tattaccagg gcaaatgcca ctgtcacatg ggaacacact gccactcctc agatgggccc      540

cgaggagtga ttccagagcc cagatgtccc tag                                   573


<210> 17
<211> 255
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="NKp44"

<400> 17
Gln Ser Lys Ala Gln Val Leu Gln Ser Val Ala Gly Gln Thr Leu Thr 
1               5                   10                  15      


Val Arg Cys Gln Tyr Pro Pro Thr Gly Ser Leu Tyr Glu Lys Lys Gly 
            20                  25                  30          


Trp Cys Lys Glu Ala Ser Ala Leu Val Cys Ile Arg Leu Val Thr Ser 
        35                  40                  45              


Ser Lys Pro Arg Thr Met Ala Trp Thr Ser Arg Phe Thr Ile Trp Asp 
    50                  55                  60                  


Asp Pro Asp Ala Gly Phe Phe Thr Val Thr Met Thr Asp Leu Arg Glu 
65                  70                  75                  80  


Glu Asp Ser Gly His Tyr Trp Cys Arg Ile Tyr Arg Pro Ser Asp Asn 
                85                  90                  95      


Ser Val Ser Lys Ser Val Arg Phe Tyr Leu Val Val Ser Pro Ala Ser 
            100                 105                 110         


Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln 
        115                 120                 125             


Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Gln Ala 
    130                 135                 140                 


Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser Gln Pro Gln Asn Ser 
145                 150                 155                 160 


Thr Leu Arg Pro Gly Pro Ala Ala Pro Ile Ala Leu Val Pro Val Phe 
                165                 170                 175     


Cys Gly Leu Leu Val Ala Lys Ser Leu Val Leu Ser Ala Leu Leu Val 
            180                 185                 190         


Trp Trp Gly Asp Ile Trp Trp Lys Thr Met Met Glu Leu Arg Ser Leu 
        195                 200                 205             


Asp Thr Gln Lys Ala Thr Cys His Leu Gln Gln Val Thr Asp Leu Pro 
    210                 215                 220                 


Trp Thr Ser Val Ser Ser Pro Val Glu Arg Glu Ile Leu Tyr His Thr 
225                 230                 235                 240 


Val Ala Arg Thr Lys Ile Ser Asp Asp Asp Asp Glu His Thr Leu 
                245                 250                 255 


<210> 18
<211> 777
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="NKp44"

<400> 18
atggcctggc gagccctaca cccactgcta ctgctgctgc tgctgttccc aggctctcag       60

gcacaatcca aggctcaggt acttcaaagt gtggcagggc agacgctaac cgtgagatgc      120

cagtacccgc ccacgggcag tctctacgag aagaaaggct ggtgtaagga ggcttcagca      180

cttgtgtgca tcaggttagt caccagctcc aagcccagga cgatggcttg gacctctcga      240

ttcacaatct gggacgaccc tgatgctggc ttcttcactg tcaccatgac tgatctgaga      300

gaggaagact caggacatta ctggtgtaga atctaccgcc cttctgacaa ctctgtctct      360

aagtccgtca gattctatct ggtggtatct ccagcctctg cctccacaca gacctcctgg      420

actccccgcg acctggtctc ttcacagacc cagacccaga gctgtgtgcc tcccactgca      480

ggagccagac aagcccctga gtctccatct accatccctg tcccttcaca gccacagaac      540

tccacgctcc gccctggccc tgcagccccc attgccctgg tgcctgtgtt ctgtggactc      600

ctcgtagcca agagcctggt gctgtcagcc ctgctcgtct ggtgggtttt aaggaatcgg      660

cacatgcagc atcaagggag gtctctgctg cacccagctc agcccaggcc ccaggcccat      720

agacacttcc cactgagcca cagggcacca ggggggacat atggtggaaa accatga         777


<210> 19
<211> 283
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="NKp46"

<400> 19
Gln Gln Gln Thr Leu Pro Lys Pro Phe Ile Trp Ala Glu Pro His Phe 
1               5                   10                  15      


Met Val Pro Lys Glu Lys Gln Val Thr Ile Cys Cys Gln Gly Asn Tyr 
            20                  25                  30          


Gly Ala Val Glu Tyr Gln Leu His Phe Glu Gly Ser Leu Phe Ala Val 
        35                  40                  45              


Asp Arg Pro Lys Pro Pro Glu Arg Ile Asn Lys Val Gln Phe Tyr Ile 
    50                  55                  60                  


Pro Asp Met Asn Ser Arg Met Ala Gly Gln Tyr Ser Cys Ile Tyr Arg 
65                  70                  75                  80  


Val Gly Glu Leu Trp Ser Glu Pro Ser Asn Leu Leu Asp Leu Val Val 
                85                  90                  95      


Thr Glu Met Tyr Asp Thr Pro Thr Leu Ser Val His Pro Gly Pro Glu 
            100                 105                 110         


Val Ile Ser Gly Glu Lys Val Thr Phe Tyr Cys Arg Leu Asp Thr Ala 
        115                 120                 125             


Thr Ser Met Phe Leu Leu Leu Lys Glu Gly Arg Ser Ser His Val Gln 
    130                 135                 140                 


Arg Gly Tyr Gly Lys Val Gln Ala Glu Phe Pro Leu Gly Pro Val Thr 
145                 150                 155                 160 


Thr Ala His Arg Gly Thr Tyr Arg Cys Phe Gly Ser Tyr Asn Asn His 
                165                 170                 175     


Ala Trp Ser Phe Pro Ser Glu Pro Val Lys Leu Leu Val Thr Gly Asp 
            180                 185                 190         


Ile Glu Asn Thr Ser Leu Ala Pro Glu Asp Pro Thr Phe Pro Ala Asp 
        195                 200                 205             


Thr Trp Gly Thr Tyr Leu Leu Thr Thr Glu Thr Gly Leu Gln Lys Asp 
    210                 215                 220                 


His Ala Leu Trp Asp His Thr Ala Gln Asn Leu Leu Arg Met Gly Leu 
225                 230                 235                 240 


Ala Phe Leu Val Leu Val Ala Leu Val Trp Phe Leu Val Glu Asp Trp 
                245                 250                 255     


Leu Ser Arg Lys Arg Thr Arg Glu Arg Ala Ser Arg Ala Ser Thr Trp 
            260                 265                 270         


Glu Gly Arg Arg Arg Leu Asn Thr Gln Thr Leu 
        275                 280             


<210> 20
<211> 777
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="NKp46"

<400> 20
atggcctggc gagccctaca cccactgcta ctgctgctgc tgctgttccc aggctctcag       60

gcacaatcca aggctcaggt acttcaaagt gtggcagggc agacgctaac cgtgagatgc      120

cagtacccgc ccacgggcag tctctacgag aagaaaggct ggtgtaagga ggcttcagca      180

cttgtgtgca tcaggttagt caccagctcc aagcccagga cgatggcttg gacctctcga      240

ttcacaatct gggacgaccc tgatgctggc ttcttcactg tcaccatgac tgatctgaga      300

gaggaagact caggacatta ctggtgtaga atctaccgcc cttctgacaa ctctgtctct      360

aagtccgtca gattctatct ggtggtatct ccagcctctg cctccacaca gacctcctgg      420

actccccgcg acctggtctc ttcacagacc cagacccaga gctgtgtgcc tcccactgca      480

ggagccagac aagcccctga gtctccatct accatccctg tcccttcaca gccacagaac      540

tccacgctcc gccctggccc tgcagccccc attgccctgg tgcctgtgtt ctgtggactc      600

ctcgtagcca agagcctggt gctgtcagcc ctgctcgtct ggtgggtttt aaggaatcgg      660

cacatgcagc atcaagggag gtctctgctg cacccagctc agcccaggcc ccaggcccat      720

agacacttcc cactgagcca cagggcacca ggggggacat atggtggaaa accatga         777


<210> 21
<211> 216
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="NKG2D"

<400> 21
Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210> 22
<211> 651
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="NKG2D"

<400> 22
atggggtgga ttcgtggtcg gaggtctcga cacagctggg agatgagtga atttcataat       60

tataacttgg atctgaagaa gagtgatttt tcaacacgat ggcaaaagca aagatgtcca      120

gtagtcaaaa gcaaatgtag agaaaatgca tctccatttt ttttctgctg cttcatcgct      180

gtagccatgg gaatccgttt cattattatg gtaacaatat ggagtgctgt attcctaaac      240

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      300

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      360

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      420

gaggaccagg atttacttaa actggtgaag tcatatcatt ggatgggact agtacacatt      480

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca      540

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata      600

gaaaactgtt caactccaaa tacgtacatc tgcatgcaaa ggactgtgta a               651


<210> 23
<211> 359
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD16"

<400> 23
Met Ala Glu Gly Thr Leu Trp Gln Ile Leu Cys Val Ser Ser Asp Ala 
1               5                   10                  15      


Gln Pro Gln Thr Phe Glu Gly Val Lys Gly Ala Asp Pro Pro Thr Leu 
            20                  25                  30          


Pro Pro Gly Ser Phe Leu Pro Gly Pro Val Leu Trp Trp Gly Ser Leu 
        35                  40                  45              


Ala Arg Leu Gln Thr Glu Lys Ser Asp Glu Val Ser Arg Lys Gly Asn 
    50                  55                  60                  


Trp Trp Val Thr Glu Met Gly Gly Gly Ala Gly Glu Arg Leu Phe Thr 
65                  70                  75                  80  


Ser Ser Cys Leu Val Gly Leu Val Pro Leu Gly Leu Arg Ile Ser Leu 
                85                  90                  95      


Val Thr Cys Pro Leu Gln Cys Gly Ile Met Trp Gln Leu Leu Leu Pro 
            100                 105                 110         


Thr Ala Leu Leu Leu Leu Val Ser Ala Gly Met Arg Thr Glu Asp Leu 
        115                 120                 125             


Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu 
    130                 135                 140                 


Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp 
145                 150                 155                 160 


Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala 
                165                 170                 175     


Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr 
            180                 185                 190         


Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu 
        195                 200                 205             


Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys 
    210                 215                 220                 


Glu Glu Asp Pro Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala 
225                 230                 235                 240 


Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe 
                245                 250                 255     


His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser 
            260                 265                 270         


Gly Ser Tyr Phe Cys Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser 
        275                 280                 285             


Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile 
    290                 295                 300                 


Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met 
305                 310                 315                 320 


Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr 
                325                 330                 335     


Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp 
            340                 345                 350         


Arg Lys Asp Pro Gln Asp Lys 
        355                 


<210> 24
<211> 1080
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD16"

<400> 24
atggctgagg gcacactctg gcagattctg tgtgtgtcct cagatgctca gccacagacc       60

tttgagggag taaagggggc agacccaccc accttgcctc caggctcttt ccttcctggt      120

cctgttctat ggtggggctc ccttgccaga cttcagactg agaagtcaga tgaagtttca      180

agaaaaggaa attggtgggt gacagagatg ggtggagggg ctggggaaag gctgtttact      240

tcctcctgtc tagtcggttt ggtcccttta gggctccgga tatctttggt gacttgtcca      300

ctccagtgtg gcatcatgtg gcagctgctc ctcccaactg ctctgctact tctagtttca      360

gctggcatgc ggactgaaga tctcccaaag gctgtggtgt tcctggagcc tcaatggtac      420

agggtgctcg agaaggacag tgtgactctg aagtgccagg gagcctactc ccctgaggac      480

aattccacac agtggtttca caatgagagc ctcatctcaa gccaggcctc gagctacttc      540

attgacgctg ccacagtcga cgacagtgga gagtacaggt gccagacaaa cctctccacc      600

ctcagtgacc cggtgcagct agaagtccat atcggctggc tgttgctcca ggcccctcgg      660

tgggtgttca aggaggaaga ccctattcac ctgaggtgtc acagctggaa gaacactgct      720

ctgcataagg tcacatattt acagaatggc aaaggcagga agtattttca tcataattct      780

gacttctaca ttccaaaagc cacactcaaa gacagcggct cctacttctg cagggggctt      840

tttgggagta aaaatgtgtc ttcagagact gtgaacatca ccatcactca aggtttggca      900

gtgtcaacca tctcatcatt ctttccacct gggtaccaag tctctttctg cttggtgatg      960

gtactccttt ttgcagtgga cacaggacta tatttctctg tgaagacaaa cattcgaagc     1020

tcaacaagag actggaagga ccataaattt aaatggagaa aggaccctca agacaaatga     1080


<210> 25
<211> 233
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD16"

<400> 25
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile 
225                 230             


<210> 26
<211> 702
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD16"

<400> 26
atgtggcagc tgctcctccc aactgctctg ctacttctag tttcagctgg catgcggact       60

gaagatctcc caaaggctgt ggtgttcctg gagcctcaat ggtacagcgt gcttgagaag      120

gacagtgtga ctctgaagtg ccagggagcc tactcccctg aggacaattc cacacagtgg      180

tttcacaatg agaacctcat ctcaagccag gcctcgagct acttcattga cgctgccaca      240

gtcaacgaca gtggagagta caggtgccag acaaacctct ccaccctcag tgacccggtg      300

cagctagaag tccatatcgg ctggctgttg ctccaggccc ctcggtgggt gttcaaggag      360

gaagacccta ttcacctgag gtgtcacagc tggaagaaca ctgctctgca taaggtcaca      420

tatttacaga atggcaaaga caggaagtat tttcatcata attctgactt ccacattcca      480

aaagccacac tcaaagatag cggctcctac ttctgcaggg ggcttgttgg gagtaaaaat      540

gtgtcttcag agactgtgaa catcaccatc actcaaggtt tggcagtgtc aaccatctca      600

tcattctctc cacctgggta ccaagtctct ttctgcttgg tgatggtact cctttttgca      660

gtggacacag gactatattt ctctgtgaag acaaacattt ga                         702


<210> 27
<211> 304
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="KIR2DS1"

<400> 27
Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Arg Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Met Phe Asn Asp Thr Leu Arg Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Ser Arg Met Lys Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Val Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Ile Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Gly Thr Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asn Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Lys Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro 
                245                 250                 255     


Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asp Lys 
            260                 265                 270         


Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Ser Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala 
    290                 295                 300                 


<210> 28
<211> 915
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="KIR2DS1"

<400> 28
atgtcgctca cggtcgtcag catggcgtgt gttgggttct tcttgctgca gggggcctgg       60

ccacatgagg gagtccacag aaaaccttcc ctcctggccc acccaggtcg cctggtgaaa      120

tcagaagaga cagtcatcct gcaatgttgg tcagatgtca tgtttgaaca cttccttctg      180

cacagagagg ggatgtttaa cgacactttg cgcctcattg gagaacacca tgatggggtc      240

tccaaggcca acttctccat cagtcgcatg aagcaagacc tggcagggac ctacagatgc      300

tacggttctg ttactcactc cccctatcag ttgtcagctc ccagtgaccc tctggacatc      360

gtgatcatag gtctatatga gaaaccttct ctctcagccc agccgggccc cacggttctg      420

gcaggagaga atgtgacctt gtcctgcagc tcccggagct cctatgacat gtaccatcta      480

tccagggaag gggaggccca tgaacgtagg ctccctgcag ggaccaaggt caacggaaca      540

ttccaggcca actttcctct gggccctgcc acccatggag ggacctacag atgcttcggc      600

tctttccgtg actctccata cgagtggtca aagtcaagtg acccactgct tgtttctgtc      660

acaggaaacc cttcaaatag ttggccttca cccactgaac caagctccga aaccggtaac      720

cccagacacc tacatgttct gattgggacc tcagtggtca aaatcccttt caccatcctc      780

ctcttctttc tccttcatcg ctggtgctcc gacaaaaaaa atgctgctgt aatggaccaa      840

gagcctgcag ggaacagaac agtgaacagc gaggattctg atgaacaaga ccatcaggag      900

gtgtcatacg cataa                                                       915


<210> 29
<211> 304
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="KIR2DS2"

<400> 29
Met Ser Leu Met Val Val Ser Met Val Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Pro Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Arg Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Tyr Lys Asp Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro 
                245                 250                 255     


Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asn Lys 
            260                 265                 270         


Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Ser Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala 
    290                 295                 300                 


<210> 30
<211> 1026
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="KIR2DS2"

<400> 30
atgtcgctca tggtcgtcag catggcgtgt gttgggttct tcttgctgca gggggcctgg       60

ccacatgagg gagtccacag aaaaccttcc ctcctggccc acccaggtcc cctggtgaaa      120

tcagaagaga cagtcatcct gcaatgttgg tcagatgtca ggtttgagca cttccttctg      180

cacagagagg ggaagtataa ggacactttg cacctcattg gagagcacca tgatggggtc      240

tccaaggcca acttctccat cggtcccatg atgcaagacc ttgcagggac ctacagatgc      300

tacggttctg ttactcactc cccctatcag ttgtcagctc ccagtgaccc tctggacatc      360

gtcatcacag gtctatatga gaaaccttct ctctcagccc agccgggccc cacggttttg      420

gcaggagaga gcgtgacctt gtcctgcagc tcccggagct cctatgacat gtaccatcta      480

tccagggagg gggaggccca tgaacgtagg ttctctgcag ggcccaaggt caacggaaca      540

ttccaggccg actttcctct gggccctgcc acccacggag gaacctacag atgcttcggc      600

tctttccgtg actctcccta tgagtggtca aactcgagtg acccactgct tgtttctgtc      660

acaggaaacc cttcaaatag ttggccttca cccactgaac caagctccaa aaccggtaac      720

cccagacacc tgcatgttct gattgggacc tcagtggtca aaatcccttt caccatcctc      780

ctcttctttc tccttcatcg ctggtgctcc aacaaaaaaa atgctgctgt aatggaccaa      840

gagcctgcag ggaacagaac agtgaacagc gaggactctg atgaacaaga ccctcaggag      900

gtgacataca cacagttgaa tcactgcgtt ttcacacaga gaaaaatcac tcgcccttct      960

cagaggccca agacaccccc aacagatatc atcgtgtaca cggaacttcc aaatgctgag     1020

tccaga                                                                1026


<210> 31
<211> 304
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="KIR2DS3"

<400> 31
Met Ser Leu Met Val Ile Ser Met Ala Cys Val Gly Phe Phe Trp Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Phe Arg Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Arg Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Thr Phe Asn Asp Thr Leu Arg Leu Ile Gly Glu His Ile Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Arg Met Arg Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Phe Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Thr Glu Gly Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr Gln 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe His Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Lys Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Leu Pro 
                245                 250                 255     


Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asp Lys 
            260                 265                 270         


Lys Asn Ala Ser Val Met Asp Gln Gly Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Arg Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala 
    290                 295                 300                 


<210> 32
<211> 915
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="KIR2DS3"

<400> 32
atgtcgctca tggtcatcag catggcatgt gttgggttct tctggctgca gggggcctgg       60

ccacatgagg gattccgcag aaaaccttcc ctcctggccc acccaggtcg cctggtgaaa      120

tcagaagaga cagtcatcct gcaatgttgg tcagatgtca tgtttgagca cttccttctg      180

cacagagagg ggacgtttaa cgacactttg cgcctcattg gagagcacat tgatggggtc      240

tccaaggcca acttctccat cggtcgcatg aggcaagacc tggcagggac ctacagatgc      300

tacggttctg ttcctcactc cccctatcag ttttcagctc ccagtgaccc tctggacatc      360

gtgatcacag gtctatatga gaaaccttct ctctcagccc agccgggccc cacggttctg      420

gcaggagaga gcgtgacctt gtcctgcagc tcctggagct cctatgacat gtaccatcta      480

tccacggagg gggaggccca tgaacgtagg ttctctgcag ggcccaaggt caacggaaca      540

ttccaggccg actttcctct gggccctgcc acccaaggag gaacctacag atgcttcggc      600

tctttccatg actctcccta cgagtggtca aagtcaagtg acccactgct tgtttctgtc      660

acaggaaacc cttcaaatag ttggccttca cccactgaac caagctccaa aaccggtaac      720

cccagacacc tacacgttct gattgggacc tcagtggtca aactcccttt caccatcctc      780

ctcttctttc tccttcatcg ctggtgctcc gacaaaaaaa atgcatctgt aatggaccaa      840

gggcctgcgg ggaacagaac agtgaacagg gaggattctg atgaacagga ccatcaggag      900

gtgtcatacg cataa                                                       915


<210> 33
<211> 354
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="KIR2DL4"

<400> 33
His Val Gly Gly Gln Asp Lys Pro Phe Cys Ser Ala Trp Pro Ser Ala 
1               5                   10                  15      


Val Val Pro Gln Gly Gly His Ala Thr Leu Arg Cys His Cys Arg Arg 
            20                  25                  30          


Gly Phe Asn Ile Phe Thr Leu Tyr Lys Lys Asp Gly Val Pro Val Pro 
        35                  40                  45              


Glu Leu Tyr Asn Arg Ile Phe Trp Asn Ser Phe Leu Ile Ser Pro Val 
    50                  55                  60                  


Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg Gly Phe His Pro His 
65                  70                  75                  80  


Ser Pro Thr Glu Trp Ser Ala Pro Ser Asn Pro Leu Val Ile Met Val 
                85                  90                  95      


Thr Gly Leu Tyr Glu Lys Pro Ser Leu Thr Ala Arg Pro Gly Pro Thr 
            100                 105                 110         


Val Arg Ala Gly Glu Asn Val Thr Leu Ser Cys Ser Ser Gln Ser Ser 
        115                 120                 125             


Phe Asp Ile Tyr His Leu Ser Arg Glu Gly Glu Ala His Glu Leu Arg 
    130                 135                 140                 


Leu Pro Ala Val Pro Ser Ile Asn Gly Thr Phe Gln Ala Asp Phe Pro 
145                 150                 155                 160 


Leu Gly Pro Ala Thr His Gly Glu Thr Tyr Arg Cys Phe Gly Ser Phe 
                165                 170                 175     


His Gly Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp Pro Leu Pro Val 
            180                 185                 190         


Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser Pro Thr Glu Pro 
        195                 200                 205             


Ser Phe Lys Thr Gly Ile Ala Arg His Leu His Ala Val Ile Arg Tyr 
    210                 215                 220                 


Ser Val Ala Ile Ile Leu Phe Thr Ile Leu Pro Phe Phe Leu Leu His 
225                 230                 235                 240 


Arg Trp Cys Ser Lys Lys Lys Asn Ala Ala Val Met Asn Gln Glu Pro 
                245                 250                 255     


Ala Gly His Arg Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro 
            260                 265                 270         


Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Ile Phe Thr Gln Arg 
        275                 280                 285             


Lys Ile Thr Gly Pro Ser Gln Arg Ser Lys Arg Pro Ser Thr Asp Thr 
    290                 295                 300                 


Ser Val Cys Ile Glu Leu Pro Asn Ala Glu Pro Arg Ala Leu Ser Pro 
305                 310                 315                 320 


Ala His Glu His His Ser Gln Ala Leu Met Gly Ser Ser Arg Glu Thr 
                325                 330                 335     


Thr Ala Leu Ser Gln Thr Gln Leu Ala Ser Ser Asn Val Pro Ala Ala 
            340                 345                 350         


Gly Ile 
        


<210> 34
<211> 1251
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="KIR2DL4"

<400> 34
atgtcccctt cacatgttgt ggtcaatgtg tcaactgcac gatccgggcc cctcaccaca       60

tcctctgcac cggtcagtcg agccgagtca ctgcgtcctg gcagcagaag ctgcaccatg      120

tccatgtcac ccacggtcat catcctggca tgtcttgggt tcttcttgga ccagagtgtg      180

tgggcacacg tgggtggtca ggacaagccc ttctgctctg cctggcccag cgctgtggtg      240

cctcaaggag gacacgtgac tcttcggtgt cactatcgtc gtgggtttaa catcttcacg      300

ctgtacaaga aagatggggt ccctgtccct gagctctaca acagaatatt ctggaacagt      360

ttcctcatta gccctgtgac cccagcacac gcagggacct acagatgtcg aggttttcac      420

ccgcactccc ccactgagtg gtcggcaccc agcaaccccc tggtgatcat ggtcacaggt      480

ctatatgaga aaccttcgct tacagcccgg ccgggcccca cggttcgcgc aggagagaac      540

gtgaccttgt cctgcagctc ccagagctcc tttgacatct accatctatc cagggagggg      600

gaagcccatg aacttaggct ccctgcagtg cccagcatca atggaacatt ccaggccgac      660

ttccctctgg gtcctgccac ccacggagag acctacagat gcttcggctc tttccatgga      720

tctccctacg agtggtcaga cccgagtgac ccactgcctg tttctgtcac aggaaaccct      780

tctagtagtt ggccttcacc cactgaacca agcttcaaaa ctggtatcgc cagacacctg      840

catgctgtga ttaggtactc agtggccatc atcctcttta ccatccttcc cttctttctc      900

cttcatcgct ggtgctccaa aaaaaaagat gctgctgtaa tgaaccaaga gcctgcggga      960

cacagaacag tgaacaggga ggactctgat gaacaagacc ctcaggaggt gacatacgca     1020

cagttggatc actgcatttt cacacagaga aaaatcactg gcccttctca gaggagcaag     1080

agaccctcaa cagataccag cgtgtgtata gaacttccaa atgctgagcc cagagcgttg     1140

tctcctgccc atgagcacca cagtcaggcc ttgatgggat cttctaggga gacaacagcc     1200

ctgtctcaaa cccagcttgc cagctctaat gtaccagcag ctggaatctg a              1251


<210> 35
<211> 218
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="KIR2DS4"

<400> 35
Gln Glu Gly Val His Arg Lys Pro Ser Phe Leu Ala Leu Pro Gly His 
1               5                   10                  15      


Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val 
            20                  25                  30          


Met Phe Glu His Phe Leu Leu His Arg Glu Gly Lys Phe Asn Asn Thr 
        35                  40                  45              


Leu His Leu Ile Gly Glu His His Asp Gly Val Ser Lys Ala Asn Phe 
    50                  55                  60                  


Ser Ile Gly Pro Met Met Pro Val Leu Ala Gly Thr Tyr Arg Cys Tyr 
65                  70                  75                  80  


Ser Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro 
                85                  90                  95      


Leu Asp Met Val Ile Ile Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala 
            100                 105                 110         


Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val Ser Leu Ser Cys 
        115                 120                 125             


Ser Ser Ile Tyr Pro Gly Arg Gly Arg Pro Met Asn Val Gly Ser Leu 
    130                 135                 140                 


Gln Cys Ala Ala Ser Thr Glu His Ser Arg Pro Thr Phe Leu Trp Ala 
145                 150                 155                 160 


Leu Pro Pro Thr Glu Gly Pro Thr Asp Ala Ser Ala Leu Ser Val Thr 
                165                 170                 175     


Leu Pro Thr Ser Gly Gln Thr Arg Val Ile His Cys Leu Phe Pro Ser 
            180                 185                 190         


Gln Glu Thr Leu Gln Ile Val Gly Leu His Pro Leu Asn Gln Ala Pro 
        195                 200                 205             


Lys Pro Val Thr Pro Asp Thr Tyr Met Phe 
    210                 215             


<210> 36
<211> 893
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="KIR2DS4"

<400> 36
atgtcgctca tggtcatcat catggcgtgt gttgggttct tcttgctgca gggggcctgg       60

ccacaggagg gagtccacag aaaaccttcc ttcctggccc tcccaggtca cctggtgaaa      120

tcagaagaga cagtcatcct gcaatgttgg tcggatgtca tgtttgagca cttccttctg      180

cacagagagg ggaagtttaa caacactttg cacctcattg gagagcacca tgatggggtt      240

tccaaggcca acttctccat tggtcccatg atgcctgtcc ttgcaggaac ctacagatgc      300

tacggttctg ttcctcactc cccctatcag ttgtcagctc ccagtgaccc tctggacatg      360

gtgatcatag gtctatatga gaaaccttct ctctcagccc agccgggccc cacggttcag      420

gcaggagaga atgtgacctt gtcctgcagc tccatctatc cagggaaggg gaggcccatg      480

aacgtaggct ccctgcagtg cgcagcatca acggaacatt ccaggccgac tttcctctgg      540

gccctgccac ccacggaggg acctacagat gcttcggctc tttccgtgac gctccctacg      600

agtggtcaaa ctcgagtgat ccactgcttg tttccgtcac aggaaaccct tcaaatagtt      660

ggccttcacc cactgaacca agctccaaaa ccggtaaccc cagacaccta catgttctga      720

ttgggacctc agtggtcaaa atccctttca ccatcctcct cttctttctc cttcatcgct      780

ggtgctccga caaaaaaaat gctgctgtaa tggaccaaga gcctgcaggg aacagaacag      840

tgaacagcga ggattctgat gaacaagacc atcaggaggt gtcatacgca taa             893


<210> 37
<211> 283
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="KIR2DS5"

<400> 37
His Glu Gly Phe Arg Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro 
1               5                   10                  15      


Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln Cys Trp Ser Asp Val 
            20                  25                  30          


Met Phe Glu His Phe Leu Leu His Arg Glu Gly Thr Phe Asn His Thr 
        35                  40                  45              


Leu Arg Leu Ile Gly Glu His Ile Asp Gly Val Ser Lys Gly Asn Phe 
    50                  55                  60                  


Ser Ile Gly Arg Met Thr Gln Asp Leu Ala Gly Thr Tyr Arg Cys Tyr 
65                  70                  75                  80  


Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro 
                85                  90                  95      


Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala 
            100                 105                 110         


Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser Val Thr Leu Ser Cys 
        115                 120                 125             


Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly Glu 
    130                 135                 140                 


Ala His Glu Arg Arg Leu Pro Ala Gly Thr Lys Val Asn Gly Thr Phe 
145                 150                 155                 160 


Gln Ala Asp Phe Pro Leu Asp Pro Ala Thr His Gly Gly Thr Tyr Arg 
                165                 170                 175     


Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu Trp Ser Lys Ser Ser 
            180                 185                 190         


Asp Pro Leu Leu Val Ser Val Thr Gly Asn Thr Ser Asn Ser Trp Pro 
        195                 200                 205             


Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn Pro Arg His Leu His 
    210                 215                 220                 


Val Leu Ile Gly Thr Ser Val Val Lys Leu Pro Phe Thr Ile Leu Leu 
225                 230                 235                 240 


Phe Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys Asn Ala Ser Val 
                245                 250                 255     


Met Asp Gln Gly Pro Ala Gly Asn Arg Thr Val Asn Arg Glu Asp Ser 
            260                 265                 270         


Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala 
        275                 280             


<210> 38
<211> 915
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="KIR2DS"

<400> 38
atgtcgctca tggtcatcag catggcgtgt gttgcgttct tcttgctgca gggggcctgg       60

ccacatgagg gattccgcag aaaaccttcc ctcctggccc acccaggtcc cctggtgaaa      120

tcagaagaga cagtcatcct gcaatgttgg tcagatgtca tgtttgagca cttccttctg      180

cacagagagg ggacgtttaa ccacactttg cgcctcattg gagagcacat tgatggggtc      240

tccaagggca acttctccat cggtcgcatg acacaagacc tggcagggac ctacagatgc      300

tacggttctg ttactcactc cccctatcag ttgtcagcgc ccagtgaccc tctggacatc      360

gtgatcacag gtctatatga gaaaccttct ctctcagccc agccgggccc cacggttctg      420

gcaggagaga gcgtgacctt gtcctgcagc tcccggagct cctatgacat gtaccatcta      480

tccagggaag gggaggccca tgaacgtagg ctccctgcag ggcccaaggt caacagaaca      540

ttccaggccg actttcctct ggaccctgcc acccacggag ggacctacag atgcttcggc      600

tctttccgtg actctccata cgagtggtca aagtcaagtg acccactgct tgtttctgtc      660

acaggaaact cttcaaatag ttggccttca cccactgaac caagctccga aaccggtaac      720

cccagacacc tacacgttct gattgggacc tcagtggtca aactcccttt caccatcctc      780

ctcttctttc tccttcatcg ctggtgctcc aacaaaaaaa atgcatctgt aatggaccaa      840

gggcctgcgg ggaacagaac agtgaacagg gaggattctg atgaacagga ccatcaggag      900

gtgtcatacg cataa                                                       915


<210> 39
<211> 361
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="KIR3DS1"

<400> 39
His Met Gly Gly Gln Asp Lys Pro Phe Leu Ser Ala Trp Pro Ser Ala 
1               5                   10                  15      


Val Val Pro Arg Gly Gly His Val Thr Leu Arg Cys His Tyr Arg His 
            20                  25                  30          


Arg Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp Arg Ile His Val Pro 
        35                  40                  45              


Ile Phe His Gly Arg Ile Phe Gln Glu Gly Phe Asn Met Ser Pro Val 
    50                  55                  60                  


Thr Thr Ala His Ala Gly Asn Tyr Thr Cys Arg Gly Ser His Pro His 
65                  70                  75                  80  


Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro Met Val Ile Met Val 
                85                  90                  95      


Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala His Pro Gly Pro Leu 
            100                 105                 110         


Val Lys Ser Gly Glu Arg Val Ile Leu Gln Cys Trp Ser Asp Ile Met 
        115                 120                 125             


Phe Glu His Phe Phe Leu His Lys Glu Gly Ile Ser Lys Asp Pro Ser 
    130                 135                 140                 


Arg Leu Val Gly Gln Ile His Asp Gly Val Ser Lys Ala Asn Phe Ser 
145                 150                 155                 160 


Ile Gly Ser Met Met Arg Ala Leu Ala Gly Thr Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Ser Val Thr His Thr Pro Tyr Gln Leu Ser Ala Pro Ser Asp Pro Leu 
            180                 185                 190         


Asp Ile Val Val Thr Gly Leu Tyr Glu Lys Pro Ser Leu Ser Ala Gln 
        195                 200                 205             


Pro Gly Pro Lys Val Gln Ala Gly Glu Ser Val Thr Leu Ser Cys Ser 
    210                 215                 220                 


Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser Arg Glu Gly Gly Ala 
225                 230                 235                 240 


His Glu Arg Arg Leu Pro Ala Val Arg Lys Val Asn Arg Thr Phe Gln 
                245                 250                 255     


Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Arg Cys 
            260                 265                 270         


Phe Gly Ser Phe Arg His Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp 
        275                 280                 285             


Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser 
    290                 295                 300                 


Pro Thr Glu Pro Ser Ser Lys Ser Gly Asn Leu Arg His Leu His Ile 
305                 310                 315                 320 


Leu Ile Gly Thr Ser Val Val Lys Ile Pro Phe Thr Ile Leu Leu Phe 
                325                 330                 335     


Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys Lys Cys Cys Cys Asn 
            340                 345                 350         


Gly Pro Arg Ala Cys Arg Glu Gln Lys 
        355                 360     


<210> 40
<211> 1149
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="KIR3DS1"

<400> 40
atgttgctca tggtcgtcag catggcgtgt gttgggttgt tcttggtcca gagggccggt       60

ccacacatgg gtggtcagga caagcccttc ctgtctgcct ggcccagcgc tgtggtgcct      120

cgcggaggac acgtgactct tcggtgtcac tatcgtcata ggtttaacaa tttcatgcta      180

tacaaagaag acagaatcca cgttcccatc ttccatggca gaatattcca ggagggcttc      240

aacatgagcc ctgtgaccac agcacatgca gggaactaca catgtcgggg ttcacaccca      300

cactccccca ctgggtggtc ggcacccagc aaccccatgg tgatcatggt cacaggaaac      360

cacagaaaac cttccctcct ggcccaccca ggtcccctgg tgaaatcagg agagagagtc      420

atcctgcaat gttggtcaga tatcatgttt gagcacttct ttctgcacaa agagtggatc      480

tctaaggacc cctcacgcct cgttggacag atccatgatg gggtctccaa ggccaatttc      540

tccatcggtt ccatgatgcg tgcccttgca gggacctaca gatgctacgg ttctgttact      600

cacaccccct atcagttgtc agctcccagt gatcccctgg acatcgtggt cacaggtcta      660

tatgagaaac cttctctctc agcccagccg ggccccaagg ttcaggcagg agagagcgtg      720

accttgtcct gtagctcccg gagctcctat gacatgtacc atctatccag ggagggggga      780

gcccatgaac gtaggctccc tgcagtgcgc aaggtcaaca gaacattcca ggcagatttc      840

cctctgggcc ctgccaccca cggagggacc tacagatgct tcggctcttt ccgtcactct      900

ccctacgagt ggtcagaccc gagtgaccca ctgcttgttt ctgtcacagg aaacccttca      960

agtagttggc cttcacccac agaaccaagc tccaaatctg gtaacctcag acacctgcac     1020

attctgattg ggacctcagt ggtcaaaatc cctttcacca tcctcctctt ctttctcctt     1080

catcgctggt gctccaacaa aaaaaaatgc tgctgtaatg gaccaagagc ctgcagggaa     1140

cagaagtga                                                             1149


<210> 41
<211> 231
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="NKG2C"

<400> 41
Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Pro 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Ser Ser Pro Asn Thr Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Leu Ala 
    130                 135                 140                 


Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu Glu Glu 
145                 150                 155                 160 


Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile Gly Val Phe 
                165                 170                 175     


Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala Phe 
            180                 185                 190         


Lys His Lys Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys Ala Val 
        195                 200                 205             


Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser Met Ile 
    210                 215                 220                 


Tyr His Cys Lys His Lys Leu 
225                 230     


<210> 42
<211> 696
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="NKG2C"

<400> 42
atgaataaac aaagaggaac cttctcagaa gtgagtctgg cccaggaccc aaagcggcag       60

caaaggaaac ctaaaggcaa taaaagctcc atttcaggaa ccgaacagga aatattccaa      120

gtagaattaa atcttcaaaa tccttccctg aatcatcaag ggattgataa aatatatgac      180

tgccaaggtt tactgccacc tccagagaag ctcactgccg aggtcctagg aatcatttgc      240

attgtcctga tggccactgt gttaaaaaca atagttctta ttcctttcct ggagcagaac      300

aatttttccc cgaatacaag aacgcagaaa gcacgtcatt gtggccattg tcctgaggag      360

tggattacat attccaacag ttgttattac attggtaagg aaagaagaac ttgggaagag      420

agtttgctgg cctgtacttc gaagaactcc agtctgcttt ctatagataa tgaagaagaa      480

atgaaatttc tggccagcat tttaccttcc tcatggattg gtgtgtttcg taacagcagt      540

catcatccat gggtgacaat aaatggtttg gctttcaaac ataagataaa agactcagat      600

aatgctgaac ttaactgtgc agtgctacaa gtaaatcgac ttaaatcagc ccagtgtgga      660

tcttcaatga tatatcattg taagcataag ctttag                                696


<210> 43
<211> 354
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="CCR7"

<400> 43
Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Asp Asn Thr Thr Val Asp 
1               5                   10                  15      


Tyr Thr Leu Phe Glu Ser Leu Cys Ser Lys Lys Asp Val Arg Asn Phe 
            20                  25                  30          


Lys Ala Trp Phe Leu Pro Ile Met Tyr Ser Ile Ile Cys Phe Val Gly 
        35                  40                  45              


Leu Leu Gly Asn Gly Leu Val Val Leu Thr Tyr Ile Tyr Phe Lys Arg 
    50                  55                  60                  


Leu Lys Thr Met Thr Asp Thr Tyr Leu Leu Asn Leu Ala Val Ala Asp 
65                  70                  75                  80  


Ile Leu Phe Leu Leu Thr Leu Pro Phe Trp Ala Tyr Ser Ala Ala Lys 
                85                  90                  95      


Ser Trp Val Phe Gly Val His Phe Cys Lys Leu Ile Phe Ala Ile Tyr 
            100                 105                 110         


Lys Met Ser Phe Phe Ser Gly Met Leu Leu Leu Leu Cys Ile Ser Ile 
        115                 120                 125             


Asp Arg Tyr Val Ala Ile Val Gln Ala Val Ser Ala His Arg His Arg 
    130                 135                 140                 


Ala Arg Val Leu Leu Ile Ser Lys Leu Ser Cys Val Gly Ile Trp Ile 
145                 150                 155                 160 


Leu Ala Thr Val Leu Ser Ile Pro Glu Leu Leu Tyr Ser Asp Leu Gln 
                165                 170                 175     


Arg Ser Ser Ser Glu Gln Ala Met Arg Cys Ser Leu Ile Thr Glu His 
            180                 185                 190         


Val Glu Ala Phe Ile Thr Ile Gln Val Ala Gln Met Val Ile Gly Phe 
        195                 200                 205             


Leu Val Pro Leu Leu Ala Met Ser Phe Cys Tyr Leu Val Ile Ile Arg 
    210                 215                 220                 


Thr Leu Leu Gln Ala Arg Asn Phe Glu Arg Asn Lys Ala Ile Lys Val 
225                 230                 235                 240 


Ile Ile Ala Val Val Val Val Phe Ile Val Phe Gln Leu Pro Tyr Asn 
                245                 250                 255     


Gly Val Val Leu Ala Gln Thr Val Ala Asn Phe Asn Ile Thr Ser Ser 
            260                 265                 270         


Thr Cys Glu Leu Ser Lys Gln Leu Asn Ile Ala Tyr Asp Val Thr Tyr 
        275                 280                 285             


Ser Leu Ala Cys Val Arg Cys Cys Val Asn Pro Phe Leu Tyr Ala Phe 
    290                 295                 300                 


Ile Gly Val Lys Phe Arg Asn Asp Leu Phe Lys Leu Phe Lys Asp Leu 
305                 310                 315                 320 


Gly Cys Leu Ser Gln Glu Gln Leu Arg Gln Trp Ser Ser Cys Arg His 
                325                 330                 335     


Ile Arg Arg Ser Ser Met Ser Val Glu Ala Glu Thr Thr Thr Thr Phe 
            340                 345                 350         


Ser Pro 
        


<210> 44
<211> 1137
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="CCR7"

<400> 44
atggacctgg ggaaaccaat gaaaagcgtg ctggtggtgg ctctccttgt cattttccag       60

gtatgcctgt gtcaagatga ggtcacggac gattacatcg gagacaacac cacagtggac      120

tacactttgt tcgagtcttt gtgctccaag aaggacgtgc ggaactttaa agcctggttc      180

ctccctatca tgtactccat catttgtttc gtgggcctac tgggcaatgg gctggtcgtg      240

ttgacctata tctatttcaa gaggctcaag accatgaccg atacctacct gctcaacctg      300

gcggtggcag acatcctctt cctcctgacc cttcccttct gggcctacag cgcggccaag      360

tcctgggtct tcggtgtcca cttttgcaag ctcatctttg ccatctacaa gatgagcttc      420

ttcagtggca tgctcctact tctttgcatc agcattgacc gctacgtggc catcgtccag      480

gctgtctcag ctcaccgcca ccgtgcccgc gtccttctca tcagcaagct gtcctgtgtg      540

ggcatctgga tactagccac agtgctctcc atcccagagc tcctgtacag tgacctccag      600

aggagcagca gtgagcaagc gatgcgatgc tctctcatca cagagcatgt ggaggccttt      660

atcaccatcc aggtggccca gatggtgatc ggctttctgg tccccctgct ggccatgagc      720

ttctgttacc ttgtcatcat ccgcaccctg ctccaggcac gcaactttga gcgcaacaag      780

gccatcaagg tgatcatcgc tgtggtcgtg gtcttcatag tcttccagct gccctacaat      840

ggggtggtcc tggcccagac ggtggccaac ttcaacatca ccagtagcac ctgtgagctc      900

agtaagcaac tcaacatcgc ctacgacgtc acctacagcc tggcctgcgt ccgctgctgc      960

gtcaaccctt tcttgtacgc cttcatcggc gtcaagttcc gcaacgatct cttcaagctc     1020

ttcaaggacc tgggctgcct cagccaggag cagctccggc agtggtcttc ctgtcggcac     1080

atccggcgct cctccatgag tgtggaggcc gagaccacca ccaccttctc cccatag        1137


<210> 45
<211> 368
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="CXCR3"

<400> 45
Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser 
        35                  40                  45              


Leu Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe 
    50                  55                  60                  


Leu Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser 
65                  70                  75                  80  


Arg Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala 
                85                  90                  95      


Val Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp 
            100                 105                 110         


Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly 
        115                 120                 125             


Ala Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys 
    130                 135                 140                 


Ile Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr 
145                 150                 155                 160 


Arg Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp 
                165                 170                 175     


Gly Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala 
            180                 185                 190         


His His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro 
        195                 200                 205             


Gln Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe 
    210                 215                 220                 


Leu Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala 
225                 230                 235                 240 


Val Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu 
                245                 250                 255     


Val Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His 
            260                 265                 270         


Leu Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg 
        275                 280                 285             


Asn Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser 
    290                 295                 300                 


Gly Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe 
305                 310                 315                 320 


Val Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu 
                325                 330                 335     


Gly Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg 
            340                 345                 350         


Arg Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
        355                 360                 365             


<210> 46
<211> 1248
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="CXCR3"

<400> 46
atggagttga ggaagtacgg ccctggaaga ctggcgggga cagttatagg aggagctgct       60

cagagtaaat cacagactaa atcagactca atcacaaaag agttcctgcc aggcctttac      120

acagcccctt cctccccgtt cccgccctca caggtgagtg accaccaagt gctaaatgac      180

gccgaggttg ccgccctcct ggagaacttc agctcttcct atgactatgg agaaaacgag      240

agtgactcgt gctgtacctc cccgccctgc ccacaggact tcagcctgaa cttcgaccgg      300

gccttcctgc cagccctcta cagcctcctc tttctgctgg ggctgctggg caacggcgcg      360

gtggcagccg tgctgctgag ccggcggaca gccctgagca gcaccgacac cttcctgctc      420

cacctagctg tagcagacac gctgctggtg ctgacactgc cgctctgggc agtggacgct      480

gccgtccagt gggtctttgg ctctggcctc tgcaaagtgg caggtgccct cttcaacatc      540

aacttctacg caggagccct cctgctggcc tgcatcagct ttgaccgcta cctgaacata      600

gttcatgcca cccagctcta ccgccggggg cccccggccc gcgtgaccct cacctgcctg      660

gctgtctggg ggctctgcct gcttttcgcc ctcccagact tcatcttcct gtcggcccac      720

cacgacgagc gcctcaacgc cacccactgc caatacaact tcccacaggt gggccgcacg      780

gctctgcggg tgctgcagct ggtggctggc tttctgctgc ccctgctggt catggcctac      840

tgctatgccc acatcctggc cgtgctgctg gtttccaggg gccagcggcg cctgcgggcc      900

atgcggctgg tggtggtggt cgtggtggcc tttgccctct gctggacccc ctatcacctg      960

gtggtgctgg tggacatcct catggacctg ggcgctttgg cccgcaactg tggccgagaa     1020

agcagggtag acgtggccaa gtcggtcacc tcaggcctgg gctacatgca ctgctgcctc     1080

aacccgctgc tctatgcctt tgtaggggtc aagttccggg agcggatgtg gatgctgctc     1140

ttgcgcctgg gctgccccaa ccagagaggg ctccagaggc agccatcgtc ttcccgccgg     1200

gattcatcct ggtctgagac ctcagaggcc tcctactcgg gcttgtga                  1248


<210> 47
<211> 344
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="L-selectin"

<400> 47
Asp Phe Leu Ala His His Gly Thr Asp Cys Trp Thr Tyr His Tyr Ser 
1               5                   10                  15      


Glu Lys Pro Met Asn Trp Gln Arg Ala Arg Arg Phe Cys Arg Asp Asn 
            20                  25                  30          


Tyr Thr Asp Leu Val Ala Ile Gln Asn Lys Ala Glu Ile Glu Tyr Leu 
        35                  40                  45              


Glu Lys Thr Leu Pro Phe Ser Arg Ser Tyr Tyr Trp Ile Gly Ile Arg 
    50                  55                  60                  


Lys Ile Gly Gly Ile Trp Thr Trp Val Gly Thr Asn Lys Ser Leu Thr 
65                  70                  75                  80  


Glu Glu Ala Glu Asn Trp Gly Asp Gly Glu Pro Asn Asn Lys Lys Asn 
                85                  90                  95      


Lys Glu Asp Cys Val Glu Ile Tyr Ile Lys Arg Asn Lys Asp Ala Gly 
            100                 105                 110         


Lys Trp Asn Asp Asp Ala Cys His Lys Leu Lys Ala Ala Leu Cys Tyr 
        115                 120                 125             


Thr Ala Ser Cys Gln Pro Trp Ser Cys Ser Gly His Gly Glu Cys Val 
    130                 135                 140                 


Glu Ile Ile Asn Asn Tyr Thr Cys Asn Cys Asp Val Gly Tyr Tyr Gly 
145                 150                 155                 160 


Pro Gln Cys Gln Phe Val Ile Gln Cys Glu Pro Leu Glu Ala Pro Glu 
                165                 170                 175     


Leu Gly Thr Met Asp Cys Thr His Pro Leu Gly Asn Phe Ser Phe Ser 
            180                 185                 190         


Ser Gln Cys Ala Phe Ser Cys Ser Glu Gly Thr Asn Leu Thr Gly Ile 
        195                 200                 205             


Glu Glu Thr Thr Cys Gly Pro Phe Gly Asn Trp Ser Ser Pro Glu Pro 
    210                 215                 220                 


Thr Cys Gln Val Ile Gln Cys Glu Pro Leu Ser Ala Pro Asp Leu Gly 
225                 230                 235                 240 


Ile Met Asn Cys Ser His Pro Leu Ala Ser Phe Ser Phe Thr Ser Ala 
                245                 250                 255     


Cys Thr Phe Ile Cys Ser Glu Gly Thr Glu Leu Ile Gly Lys Lys Lys 
            260                 265                 270         


Thr Ile Cys Glu Ser Ser Gly Ile Trp Ser Asn Pro Ser Pro Ile Cys 
        275                 280                 285             


Gln Lys Leu Asp Lys Ser Phe Ser Met Ile Lys Glu Gly Asp Tyr Asn 
    290                 295                 300                 


Pro Leu Phe Ile Pro Val Ala Val Met Val Thr Ala Phe Ser Gly Leu 
305                 310                 315                 320 


Ala Phe Ile Ile Trp Leu Ala Arg Arg Leu Lys Lys Gly Lys Lys Ser 
                325                 330                 335     


Lys Arg Ser Met Asn Asp Pro Tyr 
            340                 


<210> 48
<211> 1158
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="L-selectin"

<400> 48
atgggctgca gaagaactag agaaggacca agcaaagcca tgatatttcc atggaaatgt       60

cagagcaccc agagggactt atggaacatc ttcaagttgt gggggtggac aatgctctgt      120

tgtgatttcc tggcacatca tggaaccgac tgctggactt accattattc tgaaaaaccc      180

atgaactggc aaagggctag aagattctgc cgagacaatt acacagattt agttgccata      240

caaaacaagg cggaaattga gtatctggag aagactctgc ctttcagtcg ttcttactac      300

tggataggaa tccggaagat aggaggaata tggacgtggg tgggaaccaa caaatctctt      360

actgaagaag cagagaactg gggagatggt gagcccaaca acaagaagaa caaggaggac      420

tgcgtggaga tctatatcaa gagaaacaaa gatgcaggca aatggaacga tgacgcctgc      480

cacaaactaa aggcagccct ctgttacaca gcttcttgcc agccctggtc atgcagtggc      540

catggagaat gtgtagaaat catcaataat tacacctgca actgtgatgt ggggtactat      600

gggccccagt gtcagtttgt gattcagtgt gagcctttgg aggccccaga gctgggtacc      660

atggactgta ctcacccttt gggaaacttc agcttcagct cacagtgtgc cttcagctgc      720

tctgaaggaa caaacttaac tgggattgaa gaaaccacct gtggaccatt tggaaactgg      780

tcatctccag aaccaacctg tcaagtgatt cagtgtgagc ctctatcagc accagatttg      840

gggatcatga actgtagcca tcccctggcc agcttcagct ttacctctgc atgtaccttc      900

atctgctcag aaggaactga gttaattggg aagaagaaaa ccatttgtga atcatctgga      960

atctggtcaa atcctagtcc aatatgtcaa aaattggaca aaagtttctc aatgattaag     1020

gagggtgatt ataaccccct cttcattcca gtggcagtca tggttactgc attctctggg     1080

ttggcattta tcatttggct ggcaaggaga ttaaaaaaag gcaagaaatc caagagaagt     1140

atgaatgacc catattaa                                                   1158


<210> 49
<211> 350
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="CXCR1"


<220>
<221> MOD_RES
<222> (31)..(31)
<223> Any amino acid

<400> 49
Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Xaa Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210> 50
<211> 1053
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="CXCR1"

<400> 50
atgtcaaata ttacagatcc acagatgtgg gattttgatg atctaaattt cactggcatg       60

ccacctgcag atgaagatta cagcccctgt atgctagaaa ctgagacact caacaagtat      120

gttgtgatca tcgcctatgc cctagtgttc ctgctgagcc tgctgggaaa ctccctggtg      180

atgctggtca tcttatacag cagggtcggc cgctccgtca ctgatgtcta cctgctgaac      240

ctggccttgg ccgacctact ctttgccctg accttgccca tctgggccgc ctccaaggtg      300

aatggctgga tttttggcac attcctgtgc aaggtggtct cactcctgaa ggaagtcaac      360

ttctacagtg gcatcctgct gttggcctgc atcagtgtgg accgttacct ggccattgtc      420

catgccacac gcacactgac ccagaagcgt cacttggtca agtttgtttg tcttggctgc      480

tggggactgt ctatgaatct gtccctgccc ttcttccttt tccgccaggc ttaccatcca      540

aacaattcca gtccagtttg ctatgaggtc ctgggaaatg acacagcaaa atggcggatg      600

gtgttgcgga tcctgcctca cacctttggc ttcatcgtgc cgctgtttgt catgctgttc      660

tgctatggat tcaccctgcg tacactgttt aaggcccaca tggggcagaa gcaccgagcc      720

atgagggtca tctttgctgt cgtcctcatc ttcctgcttt gctggctgcc ctacaacctg      780

gtcctgctgg cagacaccct catgaggacc caggtgatcc aggagagctg tgagcgccgc      840

aacaacatcg gccgggccct ggatgccact gagattctgg gatttctcca tagctgcctc      900

aaccccatca tctacgcctt catcggccaa aattttcgcc atggattcct caagatcctg      960

gctatgcatg gcctggtcag caaggagttc ttggcacgtc atcgtgttac ctcctacact     1020

tcttcgtctg tcaatgtctc ttccaacctc tga                                  1053


<210> 51
<211> 360
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="CXCR2"

<400> 51
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210> 52
<211> 1083
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="CXCR2"

<400> 52
atggaagatt ttaacatgga gagtgacagc tttgaagatt tctggaaagg tgaagatctt       60

agtaattaca gttacagctc taccctgccc ccttttctac tagatgccgc cccatgtgaa      120

ccagaatccc tggaaatcaa caagtatttt gtggtcatta tctatgccct ggtattcctg      180

ctgagcctgc tgggaaactc cctcgtgatg ctggtcatct tatacagcag ggtcggccgc      240

tccgtcactg atgtctacct gctgaaccta gccttggccg acctactctt tgccctgacc      300

ttgcccatct gggccgcctc caaggtgaat ggctggattt ttggcacatt cctgtgcaag      360

gtggtctcac tcctgaagga agtcaacttc tatagtggca tcctgctact ggcctgcatc      420

agtgtggacc gttacctggc cattgtccat gccacacgca cactgaccca gaagcgctac      480

ttggtcaaat tcatatgtct cagcatctgg ggtctgtcct tgctcctggc cctgcctgtc      540

ttacttttcc gaaggaccgt ctactcatcc aatgttagcc cagcctgcta tgaggacatg      600

ggcaacaata cagcaaactg gcggatgctg ttacggatcc tgccccagtc ctttggcttc      660

atcgtgccac tgctgatcat gctgttctgc tacggattca ccctgcgtac gctgtttaag      720

gcccacatgg ggcagaagca ccgggccatg cgggtcatct ttgctgtcgt cctcatcttc      780

ctgctctgct ggctgcccta caacctggtc ctgctggcag acaccctcat gaggacccag      840

gtgatccagg agacctgtga gcgccgcaat cacatcgacc gggctctgga tgccaccgag      900

attctgggca tccttcacag ctgcctcaac cccctcatct acgccttcat tggccagaag      960

tttcgccatg gactcctcaa gattctagct atacatggct tgatcagcaa ggactccctg     1020

cccaaagaca gcaggccttc ctttgttggc tcttcttcag ggcacacttc cactactctc     1080

taa                                                                   1083


<210> 53
<211> 355
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="CXC3CR1"

<400> 53
Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210> 54
<211> 1068
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="CXC3CR1"

<400> 54
atggatcagt tccctgaatc agtgacagaa aactttgagt acgatgattt ggctgaggcc       60

tgttatattg gggacatcgt ggtctttggg actgtgttcc tgtccatatt ctactccgtc      120

atctttgcca ttggcctggt gggaaatttg ttggtagtgt ttgccctcac caacagcaag      180

aagcccaaga gtgtcaccga catttacctc ctgaacctgg ccttgtctga tctgctgttt      240

gtagccactt tgcccttctg gactcactat ttgataaatg aaaagggcct ccacaatgcc      300

atgtgcaaat tcactaccgc cttcttcttc atcggctttt ttggaagcat attcttcatc      360

accgtcatca gcattgatag gtacctggcc atcgtcctgg ccgccaactc catgaacaac      420

cggaccgtgc agcatggcgt caccatcagc ctaggcgtct gggcagcagc cattttggtg      480

gcagcacccc agttcatgtt cacaaagcag aaagaaaatg aatgccttgg tgactacccc      540

gaggtcctcc aggaaatctg gcccgtgctc cgcaatgtgg aaacaaattt tcttggcttc      600

ctactccccc tgctcattat gagttattgc tacttcagaa tcatccagac gctgttttcc      660

tgcaagaacc acaagaaagc caaagccatt aaactgatcc ttctggtggt catcgtgttt      720

ttcctcttct ggacacccta caacgttatg attttcctgg agacgcttaa gctctatgac      780

ttctttccca gttgtgacat gaggaaggat ctgaggctgg ccctcagtgt gactgagacg      840

gttgcattta gccattgttg cctgaatcct ctcatctatg catttgctgg ggagaagttc      900

agaagatacc tttaccacct gtatgggaaa tgcctggctg tcctgtgtgg gcgctcagtc      960

cacgttgatt tctcctcatc tgaatcacaa aggagcaggc atggaagtgt tctgagcagc     1020

aattttactt accacacgag tgatggagat gcattgctcc ttctctga                  1068


<210> 55
<211> 373
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="ChemR23"

<400> 55
Met Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Thr Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Thr Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe 
        115                 120                 125             


Leu Leu Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val 
                165                 170                 175     


Phe Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg 
    210                 215                 220                 


Phe Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr 
225                 230                 235                 240 


Leu Thr Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Thr Lys 
                245                 250                 255     


Lys Pro Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu 
    290                 295                 300                 


Ala Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Thr Gly Met Leu 
    370             


<210> 56
<211> 1122
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="ChemR23"

<400> 56
atgagaatgg aggatgaaga ttacaacact tccatcagtt acggtgatga ataccctgat       60

tatttagact ccattgtggt tttggaggac ttatccccct tggaagccag ggtgaccagg      120

atcttcctgg tggtggtcta cagcatcgtc tgcttcctcg ggattctggg caatggtctg      180

gtgatcatca ttgccacctt caagatgaag aagacagtga acatggtctg gttcctcaac      240

ctggcagtgg cagatttcct gttcaacgtc ttcctcccaa tccatatcac ctatgccgcc      300

atggactacc actgggtttt cgggacagcc atgtgcaaga tcagcaactt ccttctcatc      360

cacaacatgt tcaccagcgt cttcctgctg accatcatca gctctgaccg ctgcatctct      420

gtgctcctcc ctgtctggtc ccagaaccac cgcagcgttc gcctggctta catggcctgc      480

atggtcatct gggtcctggc tttcttcttg agttccccat ctctcgtctt ccgggacaca      540

gccaacctgc atgggaaaat atcctgcttc aacaacttca gcctgtccac acctgggtct      600

tcctcgtggc ccactcactc ccaaatggac cctgtggggt atagccggca catggtggtg      660

actgtcaccc gcttcctctg tggcttcctg gtcccagtcc tcatcatcac agcttgctac      720

ctcaccatcg tgtgcaaact gcagcgcaac cgcctggcca agaccaagaa gcccttcaag      780

attattgtga ccatcatcat taccttcttc ctctgctggt gcccctacca cacactcaac      840

ctcctagagc tccaccacac tgccatgcct ggctctgtct tcagcctggg tttgcccctg      900

gccactgccc ttgccattgc caacagctgc atgaacccca ttctgtatgt tttcatgggt      960

caggacttca agaagttcaa ggtggccctc ttctctcgcc tggtcaatgc tctaagtgaa     1020

gatacaggcc actcttccta ccccagccat agaagcttta ccaagatgtc atcaatgaat     1080

gagaggactt ctatgaatga gagggagacc ggcatgcttt ga                        1122


<210> 57
<211> 352
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CXCR4"

<400> 57
Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210> 58
<211> 1071
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CXCR4"

<400> 58
atgtccattc ctttgcctct tttgcagata tacacttcag ataactacac cgaggaaatg       60

ggctcagggg actatgactc catgaaggaa ccctgtttcc gtgaagaaaa tgctaatttc      120

aataaaatct tcctgcccac catctactcc atcatcttct taactggcat tgtgggcaat      180

ggattggtca tcctggtcat gggttaccag aagaaactga gaagcatgac ggacaagtac      240

aggctgcacc tgtcagtggc cgacctcctc tttgtcatca cgcttccctt ctgggcagtt      300

gatgccgtgg caaactggta ctttgggaac ttcctatgca aggcagtcca tgtcatctac      360

acagtcaacc tctacagcag tgtcctcatc ctggccttca tcagtctgga ccgctacctg      420

gccatcgtcc acgccaccaa cagtcagagg ccaaggaagc tgttggctga aaaggtggtc      480

tatgttggcg tctggatccc tgccctcctg ctgactattc ccgacttcat ctttgccaac      540

gtcagtgagg cagatgacag atatatctgt gaccgcttct accccaatga cttgtgggtg      600

gttgtgttcc agtttcagca catcatggtt ggccttatcc tgcctggtat tgtcatcctg      660

tcctgctatt gcattatcat ctccaagctg tcacactcca agggccacca gaagcgcaag      720

gccctcaaga ccacagtcat cctcatcctg gctttcttcg cctgttggct gccttactac      780

attgggatca gcatcgactc cttcatcctc ctggaaatca tcaagcaagg gtgtgagttt      840

gagaacactg tgcacaagtg gatttccatc accgaggccc tagctttctt ccactgttgt      900

ctgaacccca tcctctatgc tttccttgga gccaaattta aaacctctgc ccagcacgca      960

ctcacctctg tgagcagagg gtccagcctc aagatcctct ccaaaggaaa gcgaggtgga     1020

cattcatctg tttccactga gtctgagtct tcaagttttc actccagcta a              1071


<210> 59
<211> 352
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="CCR5"

<400> 59
Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210> 60
<211> 1059
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="CCR5"

<400> 60
atggattatc aagtgtcaag tccaatctat gacatcaatt attatacatc ggagccctgc       60

caaaaaatca atgtgaagca aatcgcagcc cgcctcctgc ctccgctcta ctcactggtg      120

ttcatctttg gttttgtggg caacatgctg gtcatcctca tcctgataaa ctgcaaaagg      180

ctgaagagca tgactgacat ctacctgctc aacctggcca tctctgacct gtttttcctt      240

cttactgtcc ccttctgggc tcactatgct gccgcccagt gggactttgg aaatacaatg      300

tgtcaactct tgacagggct ctattttata ggcttcttct ctggaatctt cttcatcatc      360

ctcctgacaa tcgataggta cctggctgtc gtccatgctg tgtttgcttt aaaagccagg      420

acggtcacct ttggggtggt gacaagtgtg atcacttggg tggtggctgt gtttgcgtct      480

ctcccaggaa tcatctttac cagatctcaa aaagaaggtc ttcattacac ctgcagctct      540

cattttccat acagtcagta tcaattctgg aagaatttcc agacattaaa gatagtcatc      600

ttggggctgg tcctgccgct gcttgtcatg gtcatctgct actcgggaat cctaaaaact      660

ctgcttcggt gtcgaaatga gaagaagagg cacagggctg tgaggcttat cttcaccatc      720

atgattgttt attttctctt ctgggctccc tacaacattg tccttctcct gaacaccttc      780

caggaattct ttggcctgaa taattgcagt agctctaaca ggttggacca agctatgcag      840

gtgacagaga ctcttgggat gacgcactgc tgcatcaacc ccatcatcta tgcctttgtc      900

ggggagaagt tcagaaacta cctcttagtc ttcttccaaa agcacattgc caaacgcttc      960

tgcaaatgct gttctatttt ccagcaagag gctcccgagc gagcaagctc agtttacacc     1020

cgatccactg gggagcagga aatatctgtg ggcttgtga                            1059


<210> 61
<211> 398
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="S1P5"

<400> 61
Met Glu Ser Gly Leu Leu Arg Pro Ala Pro Val Ser Glu Val Ile Val 
1               5                   10                  15      


Leu His Tyr Asn Tyr Thr Gly Lys Leu Arg Gly Ala Arg Tyr Gln Pro 
            20                  25                  30          


Gly Ala Gly Leu Arg Ala Asp Ala Val Val Cys Leu Ala Val Cys Ala 
        35                  40                  45              


Phe Ile Val Leu Glu Asn Leu Ala Val Leu Leu Val Leu Gly Arg His 
    50                  55                  60                  


Pro Arg Phe His Ala Pro Met Phe Leu Leu Leu Gly Ser Leu Thr Leu 
65                  70                  75                  80  


Ser Asp Leu Leu Ala Gly Ala Ala Tyr Ala Ala Asn Ile Leu Leu Ser 
                85                  90                  95      


Gly Pro Leu Thr Leu Lys Leu Ser Pro Ala Leu Trp Phe Ala Arg Glu 
            100                 105                 110         


Gly Gly Val Phe Val Ala Leu Thr Ala Ser Val Leu Ser Leu Leu Ala 
        115                 120                 125             


Ile Ala Leu Glu Arg Ser Leu Thr Met Ala Arg Arg Gly Pro Ala Pro 
    130                 135                 140                 


Val Ser Ser Arg Gly Arg Thr Leu Ala Met Ala Ala Ala Ala Trp Gly 
145                 150                 155                 160 


Val Ser Leu Leu Leu Gly Leu Leu Pro Ala Leu Gly Trp Asn Cys Leu 
                165                 170                 175     


Gly Arg Leu Asp Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys Ala 
            180                 185                 190         


Tyr Val Leu Phe Cys Val Leu Ala Phe Val Gly Ile Leu Ala Ala Ile 
        195                 200                 205             


Cys Ala Leu Tyr Ala Arg Ile Tyr Cys Gln Val Arg Ala Asn Ala Arg 
    210                 215                 220                 


Arg Leu Pro Ala Arg Pro Gly Thr Ala Gly Thr Thr Ser Thr Arg Ala 
225                 230                 235                 240 


Arg Arg Lys Pro Arg Ser Leu Ala Leu Leu Arg Thr Leu Ser Val Val 
                245                 250                 255     


Leu Leu Ala Phe Val Ala Cys Trp Gly Pro Leu Phe Leu Leu Leu Leu 
            260                 265                 270         


Leu Asp Val Ala Cys Pro Ala Arg Thr Cys Pro Val Leu Leu Gln Ala 
        275                 280                 285             


Asp Pro Phe Leu Gly Leu Ala Met Ala Asn Ser Leu Leu Asn Pro Ile 
    290                 295                 300                 


Ile Tyr Thr Leu Thr Asn Arg Asp Leu Arg His Ala Leu Leu Arg Leu 
305                 310                 315                 320 


Val Cys Cys Gly Arg His Ser Cys Gly Arg Asp Pro Ser Gly Ser Gln 
                325                 330                 335     


Gln Ser Ala Ser Ala Ala Glu Ala Ser Gly Gly Leu Arg Arg Cys Leu 
            340                 345                 350         


Pro Pro Gly Leu Asp Gly Ser Phe Ser Gly Ser Glu Arg Ser Ser Pro 
        355                 360                 365             


Gln Arg Asp Gly Leu Asp Thr Ser Gly Ser Thr Gly Ser Pro Gly Ala 
    370                 375                 380                 


Pro Thr Ala Ala Arg Thr Leu Val Ser Glu Pro Ala Ala Asp 
385                 390                 395             


<210> 62
<211> 1197
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="S1P5"

<400> 62
atggagtcgg ggctgctgcg gccggcgccg gtgagcgagg tcatcgtcct gcattacaac       60

tacaccggca agctccgcgg tgcgcgctac cagccgggtg ccggcctgcg cgccgacgcc      120

gtggtgtgcc tggcggtgtg cgccttcatc gtgctagaga atctagccgt gttgttggtg      180

ctcggacgcc acccgcgctt ccacgctccc atgttcctgc tcctgggcag cctcacgttg      240

tcggatctgc tggcaggcgc cgcctacgcc gccaacatcc tactgtcggg gccgctcacg      300

ctgaaactgt cccccgcgct ctggttcgca cgggagggag gcgtcttcgt ggcactcact      360

gcgtccgtgc tgagcctcct ggccatcgcg ctggagcgca gcctcaccat ggcgcgcagg      420

gggcccgcgc ccgtctccag tcgggggcgc acgctggcga tggcagccgc ggcctggggc      480

gtgtcgctgc tcctcgggct cctgccagcg ctgggctgga attgcctggg tcgcctggac      540

gcttgctcca ctgtcttgcc gctctacgcc aaggcctacg tgctcttctg cgtgctcgcc      600

ttcgtgggca tcctggccgc tatctgtgca ctctacgcgc gcatctactg ccaggtacgc      660

gccaacgcgc ggcgcctgcc ggcacggccc gggactgcgg ggaccacctc gacccgggcg      720

cgtcgcaagc cgcgctcgct ggccttgctg cgcacgctca gcgtggtgct cctggccttt      780

gtggcatgtt ggggccccct cttcctgctg ctgttgctcg acgtggcgtg cccggcgcgc      840

acctgtcctg tactcctgca ggccgatccc ttcctgggac tggccatggc caactcactt      900

ctgaacccca tcatctacac gctcaccaac cgcgacctgc gccacgcgct cctgcgcctg      960

gtctgctgcg gacgccactc ctgcggcaga gacccgagtg gctcccagca gtcggcgagc     1020

gcggctgagg cttccggggg cctgcgccgc tgcctgcccc cgggccttga tgggagcttc     1080

agcggctcgg agcgctcatc gccccagcgc gacgggctgg acaccagcgg ctccacaggc     1140

agccccggtg cacccacagc cgcccggact ctggtatcag aaccggctgc agactga        1197


<210> 63
<211> 951
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="cKit"

<400> 63
Gln Pro Ser Val Ser Pro Gly Glu Pro Ser Pro Pro Ser Ile His Pro 
1               5                   10                  15      


Gly Lys Ser Asp Leu Ile Val Arg Val Gly Asp Glu Ile Arg Leu Leu 
            20                  25                  30          


Cys Thr Asp Pro Gly Phe Val Lys Trp Thr Phe Glu Ile Leu Asp Glu 
        35                  40                  45              


Thr Asn Glu Asn Lys Gln Asn Glu Trp Ile Thr Glu Lys Ala Glu Ala 
    50                  55                  60                  


Thr Asn Thr Gly Lys Tyr Thr Cys Thr Asn Lys His Gly Leu Ser Asn 
65                  70                  75                  80  


Ser Ile Tyr Val Phe Val Arg Asp Pro Ala Lys Leu Phe Leu Val Asp 
                85                  90                  95      


Arg Ser Leu Tyr Gly Lys Glu Asp Asn Asp Thr Leu Val Arg Cys Pro 
            100                 105                 110         


Leu Thr Asp Pro Glu Val Thr Asn Tyr Ser Leu Lys Gly Cys Gln Gly 
        115                 120                 125             


Lys Pro Leu Pro Lys Asp Leu Arg Phe Ile Pro Asp Pro Lys Ala Gly 
    130                 135                 140                 


Ile Met Ile Lys Ser Val Lys Arg Ala Tyr His Arg Leu Cys Leu His 
145                 150                 155                 160 


Cys Ser Val Asp Gln Glu Gly Lys Ser Val Leu Ser Glu Lys Phe Ile 
                165                 170                 175     


Leu Lys Val Arg Pro Ala Phe Lys Ala Val Pro Val Val Ser Val Ser 
            180                 185                 190         


Lys Ala Ser Tyr Leu Leu Arg Glu Gly Glu Glu Phe Thr Val Thr Cys 
        195                 200                 205             


Thr Ile Lys Asp Val Ser Ser Ser Val Tyr Ser Thr Trp Lys Arg Glu 
    210                 215                 220                 


Asn Ser Gln Thr Lys Leu Gln Glu Lys Tyr Asn Ser Trp His His Gly 
225                 230                 235                 240 


Asp Phe Asn Tyr Glu Arg Gln Ala Thr Leu Thr Ile Ser Ser Ala Arg 
                245                 250                 255     


Val Asn Asp Ser Gly Val Phe Met Cys Tyr Ala Asn Asn Thr Phe Gly 
            260                 265                 270         


Ser Ala Asn Val Thr Thr Thr Leu Glu Val Val Asp Lys Gly Phe Ile 
        275                 280                 285             


Asn Ile Phe Pro Met Ile Asn Thr Thr Val Phe Val Asn Asp Gly Glu 
    290                 295                 300                 


Asn Val Asp Leu Ile Val Glu Tyr Glu Ala Phe Pro Lys Pro Glu His 
305                 310                 315                 320 


Gln Gln Trp Ile Tyr Met Asn Arg Thr Phe Thr Asp Lys Trp Glu Asp 
                325                 330                 335     


Tyr Pro Lys Ser Glu Asn Glu Ser Asn Ile Arg Tyr Val Ser Glu Leu 
            340                 345                 350         


His Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr Tyr Thr Phe Leu 
        355                 360                 365             


Val Ser Asn Ser Asp Val Asn Ala Ala Ile Ala Phe Asn Val Tyr Val 
    370                 375                 380                 


Asn Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu Val Asn Gly Met 
385                 390                 395                 400 


Leu Gln Cys Val Ala Ala Gly Phe Pro Glu Pro Thr Ile Asp Trp Tyr 
                405                 410                 415     


Phe Cys Pro Gly Thr Glu Gln Arg Cys Ser Ala Ser Val Leu Pro Val 
            420                 425                 430         


Asp Val Gln Thr Leu Asn Ser Ser Gly Pro Pro Phe Gly Lys Leu Val 
        435                 440                 445             


Val Gln Ser Ser Ile Asp Ser Ser Ala Phe Lys His Asn Gly Thr Val 
    450                 455                 460                 


Glu Cys Lys Ala Tyr Asn Asp Val Gly Lys Thr Ser Ala Tyr Phe Asn 
465                 470                 475                 480 


Phe Ala Phe Lys Gly Asn Asn Lys Glu Gln Ile His Pro His Thr Leu 
                485                 490                 495     


Phe Thr Pro Leu Leu Ile Gly Phe Val Ile Val Ala Gly Met Met Cys 
            500                 505                 510         


Ile Ile Val Met Ile Leu Thr Tyr Lys Tyr Leu Gln Lys Pro Met Tyr 
        515                 520                 525             


Glu Val Gln Trp Lys Val Val Glu Glu Ile Asn Gly Asn Asn Tyr Val 
    530                 535                 540                 


Tyr Ile Asp Pro Thr Gln Leu Pro Tyr Asp His Lys Trp Glu Phe Pro 
545                 550                 555                 560 


Arg Asn Arg Leu Ser Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly 
                565                 570                 575     


Lys Val Val Glu Ala Thr Ala Tyr Gly Leu Ile Lys Ser Asp Ala Ala 
            580                 585                 590         


Met Thr Val Ala Val Lys Met Leu Lys Pro Ser Ala His Leu Thr Glu 
        595                 600                 605             


Arg Glu Ala Leu Met Ser Glu Leu Lys Val Leu Ser Tyr Leu Gly Asn 
    610                 615                 620                 


His Met Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Ile Gly Gly Pro 
625                 630                 635                 640 


Thr Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe 
                645                 650                 655     


Leu Arg Arg Lys Arg Asp Ser Phe Ile Cys Ser Lys Gln Glu Asp His 
            660                 665                 670         


Ala Glu Ala Ala Leu Tyr Lys Asn Leu Leu His Ser Lys Glu Ser Ser 
        675                 680                 685             


Cys Ser Asp Ser Thr Asn Glu Tyr Met Asp Met Lys Pro Gly Val Ser 
    690                 695                 700                 


Tyr Val Val Pro Thr Lys Ala Asp Lys Arg Arg Ser Val Arg Ile Gly 
705                 710                 715                 720 


Ser Tyr Ile Glu Arg Asp Val Thr Pro Ala Ile Met Glu Asp Asp Glu 
                725                 730                 735     


Leu Ala Leu Asp Leu Glu Asp Leu Leu Ser Phe Ser Tyr Gln Val Ala 
            740                 745                 750         


Lys Gly Met Ala Phe Leu Ala Ser Lys Asn Cys Ile His Arg Asp Leu 
        755                 760                 765             


Ala Ala Arg Asn Ile Leu Leu Thr His Gly Arg Ile Thr Lys Ile Cys 
    770                 775                 780                 


Asp Phe Gly Leu Ala Arg Asp Ile Lys Asn Asp Ser Asn Tyr Val Val 
785                 790                 795                 800 


Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile 
                805                 810                 815     


Phe Asn Cys Val Tyr Thr Phe Glu Ser Asp Val Trp Ser Tyr Gly Ile 
            820                 825                 830         


Phe Leu Trp Glu Leu Phe Ser Leu Gly Ser Ser Pro Tyr Pro Gly Met 
        835                 840                 845             


Pro Val Asp Ser Lys Phe Tyr Lys Met Ile Lys Glu Gly Phe Arg Met 
    850                 855                 860                 


Leu Ser Pro Glu His Ala Pro Ala Glu Met Tyr Asp Ile Met Lys Thr 
865                 870                 875                 880 


Cys Trp Asp Ala Asp Pro Leu Lys Arg Pro Thr Phe Lys Gln Ile Val 
                885                 890                 895     


Gln Leu Ile Glu Lys Gln Ile Ser Glu Ser Thr Asn His Ile Tyr Ser 
            900                 905                 910         


Asn Leu Ala Asn Cys Ser Pro Asn Arg Gln Lys Pro Val Val Asp His 
        915                 920                 925             


Ser Val Arg Ile Asn Ser Val Gly Ser Thr Ala Ser Ser Ser Gln Pro 
    930                 935                 940                 


Leu Leu Val His Asp Asp Val 
945                 950     


<210> 64
<211> 2931
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="cKit"

<400> 64
atgagaggcg ctcgcggcgc ctgggatttt ctctgcgttc tgctcctact gcttcgcgtc       60

cagacaggct cttctcaacc atctgtgagt ccaggggaac cgtctccacc atccatccat      120

ccaggaaaat cagacttaat agtccgcgtg ggcgacgaga ttaggctgtt atgcactgat      180

ccgggctttg tcaaatggac ttttgagatc ctggatgaaa cgaatgagaa taagcagaat      240

gaatggatca cggaaaaggc agaagccacc aacaccggca aatacacgtg caccaacaaa      300

cacggcttaa gcaattccat ttatgtgttt gttagagatc ctgccaagct tttccttgtt      360

gaccgctcct tgtatgggaa agaagacaac gacacgctgg tccgctgtcc tctcacagac      420

ccagaagtga ccaattattc cctcaagggg tgccagggga agcctcttcc caaggacttg      480

aggtttattc ctgaccccaa ggcgggcatc atgatcaaaa gtgtgaaacg cgcctaccat      540

cggctctgtc tgcattgttc tgtggaccag gagggcaagt cagtgctgtc ggaaaaattc      600

atcctgaaag tgaggccagc cttcaaagct gtgcctgttg tgtctgtgtc caaagcaagc      660

tatcttctta gggaagggga agaattcaca gtgacgtgca caataaaaga tgtgtctagt      720

tctgtgtact caacgtggaa aagagaaaac agtcagacta aactacagga gaaatataat      780

agctggcatc acggtgactt caattatgaa cgtcaggcaa cgttgactat cagttcagcg      840

agagttaatg attctggagt gttcatgtgt tatgccaata atacttttgg atcagcaaat      900

gtcacaacaa ccttggaagt agtagataaa ggattcatta atatcttccc catgataaac      960

actacagtat ttgtaaacga tggagaaaat gtagatttga ttgttgaata tgaagcattc     1020

cccaaacctg aacaccagca gtggatctat atgaacagaa ccttcactga taaatgggaa     1080

gattatccca agtctgagaa tgaaagtaat atcagatacg taagtgaact tcatctaacg     1140

agattaaaag gcaccgaagg aggcacttac acattcctag tgtccaattc tgacgtcaat     1200

gctgccatag catttaatgt ttatgtgaat acaaaaccag aaatcctgac ttacgacagg     1260

ctcgtgaatg gcatgctcca atgtgtggca gcaggattcc cagagcccac aatagattgg     1320

tatttttgtc caggaactga gcagagatgc tctgcttctg tactgccagt ggatgtgcag     1380

acactaaact catctgggcc accgtttgga aagctagtgg ttcagagttc tatagattct     1440

agtgcattca agcacaatgg cacggttgaa tgtaaggctt acaacgatgt gggcaagact     1500

tctgcctatt ttaactttgc atttaaaggt aacaacaaag agcaaatcca tccccacacc     1560

ctgttcactc ctttgctgat tggtttcgta atcgtagctg gcatgatgtg cattattgtg     1620

atgattctga cctacaaata tttacagaaa cccatgtatg aagtacagtg gaaggttgtt     1680

gaggagataa atggaaacaa ttatgtttac atagacccaa cacaacttcc ttatgatcac     1740

aaatgggagt ttcccagaaa caggctgagt tttgggaaaa ccctgggtgc tggagctttc     1800

gggaaggttg ttgaggcaac tgcttatggc ttaattaagt cagatgcggc catgactgtc     1860

gctgtaaaga tgctcaagcc gagtgcccat ttgacagaac gggaagccct catgtctgaa     1920

ctcaaagtcc tgagttacct tggtaatcac atgaatattg tgaatctact tggagcctgc     1980

accattggag ggcccaccct ggtcattaca gaatattgtt gctatggtga tcttttgaat     2040

tttttgagaa gaaaacgtga ttcatttatt tgttcaaagc aggaagatca tgcagaagct     2100

gcactttata agaatcttct gcattcaaag gagtcttcct gcagcgatag tactaatgag     2160

tacatggaca tgaaacctgg agtttcttat gttgtcccaa ccaaggccga caaaaggaga     2220

tctgtgagaa taggctcata catagaaaga gatgtgactc ccgccatcat ggaggatgac     2280

gagttggccc tagacttaga agacttgctg agcttttctt accaggtggc aaagggcatg     2340

gctttcctcg cctccaagaa ttgtattcac agagacttgg cagccagaaa tatcctcctt     2400

actcatggtc ggatcacaaa gatttgtgat tttggtctag ccagagacat caagaatgat     2460

tctaattatg tggttaaagg aaacgctcga ctacctgtga agtggatggc acctgaaagc     2520

attttcaact gtgtatacac gtttgaaagt gacgtctggt cctatgggat ttttctttgg     2580

gagctgttct ctttaggaag cagcccctat cctggaatgc cggtcgattc taagttctac     2640

aagatgatca aggaaggctt ccggatgctc agccctgaac acgcacctgc tgaaatgtat     2700

gacataatga agacttgctg ggatgcagat cccctaaaaa gaccaacatt caagcaaatt     2760

gttcagctaa ttgagaagca gatttcagag agcaccaatc atatttactc caacttagca     2820

aactgcagcc ccaaccgaca gaagcccgtg gtagaccatt ctgtgcggat caattctgtc     2880

ggcagcaccg cttcctcctc ccagcctctg cttgtgcacg acgatgtctg a              2931


<210> 65
<211> 2549
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="mTor"

<400> 65
Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210> 66
<211> 7650
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="mTor"

<400> 66
atgcttggaa ccggacctgc cgccgccacc accgctgcca ccacatctag caatgtgagc       60

gtcctgcagc agtttgccag tggcctaaag agccggaatg aggaaaccag ggccaaagcc      120

gccaaggagc tccagcacta tgtcaccatg gaactccgag agatgagtca agaggagtct      180

actcgcttct atgaccaact gaaccatcac atttttgaat tggtttccag ctcagatgcc      240

aatgagagga aaggtggcat cttggccata gctagcctca taggagtgga aggtgggaat      300

gccacccgaa ttggcagatt tgccaactat cttcggaacc tcctcccctc caatgaccca      360

gttgtcatgg aaatggcatc caaggccatt ggccgtcttg ccatggcagg ggacactttt      420

accgctgagt acgtggaatt tgaggtgaag cgagccctgg aatggctggg tgctgaccgc      480

aatgagggcc ggagacatgc agctgtcctg gttctccgtg agctggccat cagcgtccct      540

accttcttct tccagcaagt gcaacccttc tttgacaaca tttttgtggc cgtgtgggac      600

cccaaacagg ccatccgtga gggagctgta gccgcccttc gtgcctgtct gattctcaca      660

acccagcgtg agccgaagga gatgcagaag cctcagtggt acaggcacac atttgaagaa      720

gcagagaagg gatttgatga gaccttggcc aaagagaagg gcatgaatcg ggatgatcgg      780

atccatggag ccttgttgat ccttaacgag ctggtccgaa tcagcagcat ggagggagag      840

cgtctgagag aagaaatgga agaaatcaca cagcagcagc tggtacacga caagtactgc      900

aaagatctca tgggcttcgg aacaaaacct cgtcacatta cccccttcac cagtttccag      960

gctgtacagc cccagcagtc aaatgccttg gtggggctgc tggggtacag ctctcaccaa     1020

ggcctcatgg gatttgggac ctcccccagt ccagctaagt ccaccctggt ggagagccgg     1080

tgttgcagag acttgatgga ggagaaattt gatcaggtgt gccagtgggt gctgaaatgc     1140

aggaatagca agaactcgct gatccaaatg acaatcctta atttgttgcc ccgcttggct     1200

gcattccgac cttctgcctt cacagatacc cagtatctcc aagataccat gaaccatgtc     1260

ctaagctgtg tcaagaagga gaaggaacgt acagcggcct tccaagccct ggggctactt     1320

tctgtggctg tgaggtctga gtttaaggtc tatttgcctc gcgtgctgga catcatccga     1380

gcggccctgc ccccaaagga cttcgcccat aagaggcaga aggcaatgca ggtggatgcc     1440

acagtcttca cttgcatcag catgctggct cgagcaatgg ggccaggcat ccagcaggat     1500

atcaaggagc tgctggagcc catgctggca gtgggactaa gccctgccct cactgcagtg     1560

ctctacgacc tgagccgtca gattccacag ctaaagaagg acattcaaga tgggctactg     1620

aaaatgctgt ccctggtcct tatgcacaaa ccccttcgcc acccaggcat gcccaagggc     1680

ctggcccatc agctggcctc tcctggcctc acgaccctcc ctgaggccag cgatgtgggc     1740

agcatcactc ttgccctccg aacgcttggc agctttgaat ttgaaggcca ctctctgacc     1800

caatttgttc gccactgtgc ggatcatttc ctgaacagtg agcacaagga gatccgcatg     1860

gaggctgccc gcacctgctc ccgcctgctc acaccctcca tccacctcat cagtggccat     1920

gctcatgtgg ttagccagac cgcagtgcaa gtggtggcag atgtgcttag caaactgctc     1980

gtagttggga taacagatcc tgaccctgac attcgctact gtgtcttggc gtccctggac     2040

gagcgctttg atgcacacct ggcccaggcg gagaacttgc aggccttgtt tgtggctctg     2100

aatgaccagg tgtttgagat ccgggagctg gccatctgca ctgtgggccg actcagtagc     2160

atgaaccctg cctttgtcat gcctttcctg cgcaagatgc tcatccagat tttgacagag     2220

ttggagcaca gtgggattgg aagaatcaaa gagcagagtg cccgcatgct ggggcacctg     2280

gtctccaatg ccccccgact catccgcccc tacatggagc ctattctgaa ggcattaatt     2340

ttgaaactga aagatccaga ccctgatcca aacccaggtg tgatcaataa tgtcctggca     2400

acaataggag aattggcaca ggttagtggc ctggaaatga ggaaatgggt tgatgaactt     2460

tttattatca tcatggacat gctccaggat tcctctttgt tggccaaaag gcaggtggct     2520

ctgtggaccc tgggacagtt ggtggccagc actggctatg tagtagagcc ctacaggaag     2580

taccctactt tgcttgaggt gctactgaat tttctgaaga ctgagcagaa ccagggtaca     2640

cgcagagagg ccatccgtgt gttagggctt ttaggggctt tggatcctta caagcacaaa     2700

gtgaacattg gcatgataga ccagtcccgg gatgcctctg ctgtcagcct gtcagaatcc     2760

aagtcaagtc aggattcctc tgactatagc actagtgaaa tgctggtcaa catgggaaac     2820

ttgcctctgg atgagttcta cccagctgtg tccatggtgg ccctgatgcg gatcttccga     2880

gaccagtcac tctctcatca tcacaccatg gttgtccagg ccatcacctt catcttcaag     2940

tccctgggac tcaaatgtgt gcagttcctg ccccaggtca tgcccacgtt ccttaacgtc     3000

attcgagtct gtgatggggc catccgggaa tttttgttcc agcagctggg aatgttggtg     3060

tcctttgtga agagccacat cagaccttat atggatgaaa tagtcaccct catgagagaa     3120

ttctgggtca tgaacacctc aattcagagc acgatcattc ttctcattga gcaaattgtg     3180

gtagctcttg ggggtgaatt taagctctac ctgccccagc tgatcccaca catgctgcgt     3240

gtcttcatgc atgacaacag cccaggccgc attgtctcta tcaagttact ggctgcaatc     3300

cagctgtttg gcgccaacct ggatgactac ctgcatttac tgctgcctcc tattgttaag     3360

ttgtttgatg cccctgaagc tccactgcca tctcgaaagg cagcgctaga gactgtggac     3420

cgcctgacgg agtccctgga tttcactgac tatgcctccc ggatcattca ccctattgtt     3480

cgaacactgg accagagccc agaactgcgc tccacagcca tggacacgct gtcttcactt     3540

gtttttcagc tggggaagaa gtaccaaatt ttcattccaa tggtgaataa agttctggtg     3600

cgacaccgaa tcaatcatca gcgctatgat gtgctcatct gcagaattgt caagggatac     3660

acacttgctg atgaagagga ggatcctttg atttaccagc atcggatgct taggagtggc     3720

caaggggatg cattggctag tggaccagtg gaaacaggac ccatgaagaa actgcacgtc     3780

agcaccatca acctccaaaa ggcctggggc gctgccagga gggtctccaa agatgactgg     3840

ctggaatggc tgagacggct gagcctggag ctgctgaagg actcatcatc gccctccctg     3900

cgctcctgct gggccctggc acaggcctac aacccgatgg ccagggatct cttcaatgct     3960

gcatttgtgt cctgctggtc tgaactgaat gaagatcaac aggatgagct catcagaagc     4020

atcgagttgg ccctcacctc acaagacatc gctgaagtca cacagaccct cttaaacttg     4080

gctgaattca tggaacacag tgacaagggc cccctgccac tgagagatga caatggcatt     4140

gttctgctgg gtgagagagc tgccaagtgc cgagcatatg ccaaagcact acactacaaa     4200

gaactggagt tccagaaagg ccccacccct gccattctag aatctctcat cagcattaat     4260

aataagctac agcagccgga ggcagcggcc ggagtgttag aatatgccat gaaacacttt     4320

ggagagctgg agatccaggc tacctggtat gagaaactgc acgagtggga ggatgccctt     4380

gtggcctatg acaagaaaat ggacaccaac aaggacgacc cagagctgat gctgggccgc     4440

atgcgctgcc tcgaggcctt gggggaatgg ggtcaactcc accagcagtg ctgtgaaaag     4500

tggaccctgg ttaatgatga gacccaagcc aagatggccc ggatggctgc tgcagctgca     4560

tggggtttag gtcagtggga cagcatggaa gaatacacct gtatgatccc tcgggacacc     4620

catgatgggg cattttatag agctgtgctg gcactgcatc aggacctctt ctccttggca     4680

caacagtgca ttgacaaggc cagggacctg ctggatgctg aattaactgc gatggcagga     4740

gagagttaca gtcgggcata tggggccatg gtttcttgcc acatgctgtc cgagctggag     4800

gaggttatcc agtacaaact tgtccccgag cgacgagaga tcatccgcca gatctggtgg     4860

gagagactgc agggctgcca gcgtatcgta gaggactggc agaaaatcct tatggtgcgg     4920

tcccttgtgg tcagccctca tgaagacatg agaacctggc tcaagtatgc aagcctgtgc     4980

ggcaagagtg gcaggctggc tcttgctcat aaaactttag tgttgctcct gggagttgat     5040

ccgtctcggc aacttgacca tcctctgcca acagttcacc ctcaggtgac ctatgcctac     5100

atgaaaaaca tgtggaagag tgcccgcaag atcgatgcct tccagcacat gcagcatttt     5160

gtccagacca tgcagcaaca ggcccagcat gccatcgcta ctgaggacca gcagcataag     5220

caggaactgc acaagctcat ggcccgatgc ttcctgaaac ttggagagtg gcagctgaat     5280

ctacagggca tcaatgagag cacaatcccc aaagtgctgc agtactacag cgccgccaca     5340

gagcacgacc gcagctggta caaggcctgg catgcgtggg cagtgatgaa cttcgaagct     5400

gtgctacact acaaacatca gaaccaagcc cgcgatgaga agaagaaact gcgtcatgcc     5460

agcggggcca acatcaccaa cgccaccact gccgccacca cggccgccac tgccaccacc     5520

actgccagca ccgagggcag caacagtgag agcgaggccg agagcaccga gaacagcccc     5580

accccatcgc cgctgcagaa gaaggtcact gaggatctgt ccaaaaccct cctgatgtac     5640

acggtgcctg ccgtccaggg cttcttccgt tccatctcct tgtcacgagg caacaacctc     5700

caggatacac tcagagttct caccttatgg tttgattatg gtcactggcc agatgtcaat     5760

gaggccttag tggagggggt gaaagccatc cagattgata cctggctaca ggttatacct     5820

cagctcattg caagaattga tacgcccaga cccttggtgg gacgtctcat tcaccagctt     5880

ctcacagaca ttggtcggta ccacccccag gccctcatct acccactgac agtggcttct     5940

aagtctacca cgacagcccg gcacaatgca gccaacaaga ttctgaagaa catgtgtgag     6000

cacagcaaca ccctggtcca gcaggccatg atggtgagcg aggagctgat ccgagtggcc     6060

atcctctggc atgagatgtg gcatgaaggc ctggaagagg catctcgttt gtactttggg     6120

gaaaggaacg tgaaaggcat gtttgaggtg ctggagccct tgcatgctat gatggaacgg     6180

ggcccccaga ctctgaagga aacatccttt aatcaggcct atggtcgaga tttaatggag     6240

gcccaagagt ggtgcaggaa gtacatgaaa tcagggaatg tcaaggacct cacccaagcc     6300

tgggacctct attatcatgt gttccgacga atctcaaagc agctgcctca gctcacatcc     6360

ttagagctgc aatatgtttc cccaaaactt ctgatgtgcc gggaccttga attggctgtg     6420

ccaggaacat atgaccccaa ccagccaatc attcgcattc agtccatagc accgtctttg     6480

caagtcatca catccaagca gaggccccgg aaattgacac ttatgggcag caacggacat     6540

gagtttgttt tccttctaaa aggccatgaa gatctgcgcc aggatgagcg tgtgatgcag     6600

ctcttcggcc tggttaacac ccttctggcc aatgacccaa catctcttcg gaaaaacctc     6660

agcatccaga gatacgctgt catcccttta tcgaccaact cgggcctcat tggctgggtt     6720

ccccactgtg acacactgca cgccctcatc cgggactaca gggagaagaa gaagatcctt     6780

ctcaacatcg agcatcgcat catgttgcgg atggctccgg actatgacca cttgactctg     6840

atgcagaagg tggaggtgtt tgagcatgcc gtcaataata cagctgggga cgacctggcc     6900

aagctgctgt ggctgaaaag ccccagctcc gaggtgtggt ttgaccgaag aaccaattat     6960

acccgttctt tagcggtcat gtcaatggtt gggtatattt taggcctggg agatagacac     7020

ccatccaacc tgatgctgga ccgtctgagt gggaagatcc tgcacattga ctttggggac     7080

tgctttgagg ttgctatgac ccgagagaag tttccagaga agattccatt tagactaaca     7140

agaatgttga ccaatgctat ggaggttaca ggcctggatg gcaactacag aatcacatgc     7200

cacacagtga tggaggtgct gcgagagcac aaggacagtg tcatggccgt gctggaagcc     7260

tttgtctatg accccttgct gaactggagg ctgatggaca caaataccaa aggcaacaag     7320

cgatcccgaa cgaggacgga ttcctactct gctggccagt cagtcgaaat tttggacggt     7380

gtggaacttg gagagccagc ccataagaaa acggggacca cagtgccaga atctattcat     7440

tctttcattg gagacggttt ggtgaaacca gaggccctaa ataagaaagc tatccagatt     7500

attaacaggg ttcgagataa gctcactggt cgggacttct ctcatgatga cactttggat     7560

gttccaacgc aagttgagct gctcatcaaa caagcgacat cccatgaaaa cctctgccag     7620

tgctatattg gctggtgccc tttctggtaa                                      7650


<210> 67
<211> 1147
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="SREBP1"

<400> 67
Met Asp Glu Pro Pro Phe Ser Glu Ala Ala Leu Glu Gln Ala Leu Gly 
1               5                   10                  15      


Glu Pro Cys Asp Leu Asp Ala Ala Leu Leu Thr Asp Ile Glu Asp Met 
            20                  25                  30          


Leu Gln Leu Ile Asn Asn Gln Asp Ser Asp Phe Pro Gly Leu Phe Asp 
        35                  40                  45              


Pro Pro Tyr Ala Gly Ser Gly Ala Gly Gly Thr Asp Pro Ala Ser Pro 
    50                  55                  60                  


Asp Thr Ser Ser Pro Gly Ser Leu Ser Pro Pro Pro Ala Thr Leu Ser 
65                  70                  75                  80  


Ser Ser Leu Glu Ala Phe Leu Ser Gly Pro Gln Ala Ala Pro Ser Pro 
                85                  90                  95      


Leu Ser Pro Pro Gln Pro Ala Pro Thr Pro Leu Lys Met Tyr Pro Ser 
            100                 105                 110         


Met Pro Ala Phe Ser Pro Gly Pro Gly Ile Lys Glu Glu Ser Val Pro 
        115                 120                 125             


Leu Ser Ile Leu Gln Thr Pro Thr Pro Gln Pro Leu Pro Gly Ala Leu 
    130                 135                 140                 


Leu Pro Gln Ser Phe Pro Ala Pro Ala Pro Pro Gln Phe Ser Ser Thr 
145                 150                 155                 160 


Pro Val Leu Gly Tyr Pro Ser Pro Pro Gly Gly Phe Ser Thr Gly Ser 
                165                 170                 175     


Pro Pro Gly Asn Thr Gln Gln Pro Leu Pro Gly Leu Pro Leu Ala Ser 
            180                 185                 190         


Pro Pro Gly Val Pro Pro Val Ser Leu His Thr Gln Val Gln Ser Val 
        195                 200                 205             


Val Pro Gln Gln Leu Leu Thr Val Thr Ala Ala Pro Thr Ala Ala Pro 
    210                 215                 220                 


Val Thr Thr Thr Val Thr Ser Gln Ile Gln Gln Val Pro Val Leu Leu 
225                 230                 235                 240 


Gln Pro His Phe Ile Lys Ala Asp Ser Leu Leu Leu Thr Ala Met Lys 
                245                 250                 255     


Thr Asp Gly Ala Thr Val Lys Ala Ala Gly Leu Ser Pro Leu Val Ser 
            260                 265                 270         


Gly Thr Thr Val Gln Thr Gly Pro Leu Pro Thr Leu Val Ser Gly Gly 
        275                 280                 285             


Thr Ile Leu Ala Thr Val Pro Leu Val Val Asp Ala Glu Lys Leu Pro 
    290                 295                 300                 


Ile Asn Arg Leu Ala Ala Gly Ser Lys Ala Pro Ala Ser Ala Gln Ser 
305                 310                 315                 320 


Arg Gly Glu Lys Arg Thr Ala His Asn Ala Ile Glu Lys Arg Tyr Arg 
                325                 330                 335     


Ser Ser Ile Asn Asp Lys Ile Ile Glu Leu Lys Asp Leu Val Val Gly 
            340                 345                 350         


Thr Glu Ala Lys Leu Asn Lys Ser Ala Val Leu Arg Lys Ala Ile Asp 
        355                 360                 365             


Tyr Ile Arg Phe Leu Gln His Ser Asn Gln Lys Leu Lys Gln Glu Asn 
    370                 375                 380                 


Leu Ser Leu Arg Thr Ala Val His Lys Ser Lys Ser Leu Lys Asp Leu 
385                 390                 395                 400 


Val Ser Ala Cys Gly Ser Gly Gly Asn Thr Asp Val Leu Met Glu Gly 
                405                 410                 415     


Val Lys Thr Glu Val Glu Asp Thr Leu Thr Pro Pro Pro Ser Asp Ala 
            420                 425                 430         


Gly Ser Pro Phe Gln Ser Ser Pro Leu Ser Leu Gly Ser Arg Gly Ser 
        435                 440                 445             


Gly Ser Gly Gly Ser Gly Ser Asp Ser Glu Pro Asp Ser Pro Val Phe 
    450                 455                 460                 


Glu Asp Ser Lys Ala Lys Pro Glu Gln Arg Pro Ser Leu His Ser Arg 
465                 470                 475                 480 


Gly Met Leu Asp Arg Ser Arg Leu Ala Leu Cys Thr Leu Val Phe Leu 
                485                 490                 495     


Cys Leu Ser Cys Asn Pro Leu Ala Ser Leu Leu Gly Ala Arg Gly Leu 
            500                 505                 510         


Pro Ser Pro Ser Asp Thr Thr Ser Val Tyr His Ser Pro Gly Arg Asn 
        515                 520                 525             


Val Leu Gly Thr Glu Ser Arg Asp Gly Pro Gly Trp Ala Gln Trp Leu 
    530                 535                 540                 


Leu Pro Pro Val Val Trp Leu Leu Asn Gly Leu Leu Val Leu Val Ser 
545                 550                 555                 560 


Leu Val Leu Leu Phe Val Tyr Gly Glu Pro Val Thr Arg Pro His Ser 
                565                 570                 575     


Gly Pro Ala Val Tyr Phe Trp Arg His Arg Lys Gln Ala Asp Leu Asp 
            580                 585                 590         


Leu Ala Arg Gly Asp Phe Ala Gln Ala Ala Gln Gln Leu Trp Leu Ala 
        595                 600                 605             


Leu Arg Ala Leu Gly Arg Pro Leu Pro Thr Ser His Leu Asp Leu Ala 
    610                 615                 620                 


Cys Ser Leu Leu Trp Asn Leu Ile Arg His Leu Leu Gln Arg Leu Trp 
625                 630                 635                 640 


Val Gly Arg Trp Leu Ala Gly Arg Ala Gly Gly Leu Gln Gln Asp Cys 
                645                 650                 655     


Ala Leu Arg Val Asp Ala Ser Ala Ser Ala Arg Asp Ala Ala Leu Val 
            660                 665                 670         


Tyr His Lys Leu His Gln Leu His Thr Met Gly Lys His Thr Gly Gly 
        675                 680                 685             


His Leu Thr Ala Thr Asn Leu Ala Leu Ser Ala Leu Asn Leu Ala Glu 
    690                 695                 700                 


Cys Ala Gly Asp Ala Val Ser Val Ala Thr Leu Ala Glu Ile Tyr Val 
705                 710                 715                 720 


Ala Ala Ala Leu Arg Val Lys Thr Ser Leu Pro Arg Ala Leu His Phe 
                725                 730                 735     


Leu Thr Arg Phe Phe Leu Ser Ser Ala Arg Gln Ala Cys Leu Ala Gln 
            740                 745                 750         


Ser Gly Ser Val Pro Pro Ala Met Gln Trp Leu Cys His Pro Val Gly 
        755                 760                 765             


His Arg Phe Phe Val Asp Gly Asp Trp Ser Val Leu Ser Thr Pro Trp 
    770                 775                 780                 


Glu Ser Leu Tyr Ser Leu Ala Gly Asn Pro Val Asp Pro Leu Ala Gln 
785                 790                 795                 800 


Val Thr Gln Leu Phe Arg Glu His Leu Leu Glu Arg Ala Leu Asn Cys 
                805                 810                 815     


Val Thr Gln Pro Asn Pro Ser Pro Gly Ser Ala Asp Gly Asp Lys Glu 
            820                 825                 830         


Phe Ser Asp Ala Leu Gly Tyr Leu Gln Leu Leu Asn Ser Cys Ser Asp 
        835                 840                 845             


Ala Ala Gly Ala Pro Ala Tyr Ser Phe Ser Ile Ser Ser Ser Met Ala 
    850                 855                 860                 


Thr Thr Thr Gly Val Asp Pro Val Ala Lys Trp Trp Ala Ser Leu Thr 
865                 870                 875                 880 


Ala Val Val Ile His Trp Leu Arg Arg Asp Glu Glu Ala Ala Glu Arg 
                885                 890                 895     


Leu Cys Pro Leu Val Glu His Leu Pro Arg Val Leu Gln Glu Ser Glu 
            900                 905                 910         


Arg Pro Leu Pro Arg Ala Ala Leu His Ser Phe Lys Ala Ala Arg Ala 
        915                 920                 925             


Leu Leu Gly Cys Ala Lys Ala Glu Ser Gly Pro Ala Ser Leu Thr Ile 
    930                 935                 940                 


Cys Glu Lys Ala Ser Gly Tyr Leu Gln Asp Ser Leu Ala Thr Thr Pro 
945                 950                 955                 960 


Ala Ser Ser Ser Ile Asp Lys Ala Val Gln Leu Phe Leu Cys Asp Leu 
                965                 970                 975     


Leu Leu Val Val Arg Thr Ser Leu Trp Arg Gln Gln Gln Pro Pro Ala 
            980                 985                 990         


Pro Ala Pro Ala Ala Gln Gly Thr  Ser Ser Arg Pro Gln  Ala Ser Ala 
        995                 1000                 1005             


Leu Glu  Leu Arg Gly Phe Gln  Arg Asp Leu Ser Ser  Leu Arg Arg 
    1010                 1015                 1020             


Leu Ala  Gln Ser Phe Arg Pro  Ala Met Arg Arg Val  Phe Leu His 
    1025                 1030                 1035             


Glu Ala  Thr Ala Arg Leu Met  Ala Gly Ala Ser Pro  Thr Arg Thr 
    1040                 1045                 1050             


His Gln  Leu Leu Asp Arg Ser  Leu Arg Arg Arg Ala  Gly Pro Gly 
    1055                 1060                 1065             


Gly Lys  Gly Gly Ala Val Ala  Glu Leu Glu Pro Arg  Pro Thr Arg 
    1070                 1075                 1080             


Arg Glu  His Ala Glu Ala Leu  Leu Leu Ala Ser Cys  Tyr Leu Pro 
    1085                 1090                 1095             


Pro Gly  Phe Leu Ser Ala Pro  Gly Gln Arg Val Gly  Met Leu Ala 
    1100                 1105                 1110             


Glu Ala  Ala Arg Thr Leu Glu  Lys Leu Gly Asp Arg  Arg Leu Leu 
    1115                 1120                 1125             


His Asp  Cys Gln Gln Met Leu  Met Arg Leu Gly Gly  Gly Thr Thr 
    1130                 1135                 1140             


Val Thr  Ser Ser 
    1145         


<210> 68
<211> 3444
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="SREBP1"

<400> 68
atggacgagc cacccttcag cgaggcggct ttggagcagg cgctgggcga gccgtgcgat       60

ctggacgcgg cgctgctgac cgacatcgaa gacatgcttc agcttatcaa caaccaagac      120

agtgacttcc ctggcctatt tgacccaccc tatgctggga gtggggcagg gggcacagac      180

cctgccagcc ccgataccag ctccccaggc agcttgtctc cacctcctgc cacattgagc      240

tcctctcttg aagccttcct gagcgggccg caggcagcgc cctcacccct gtcccctccc      300

cagcctgcac ccactccatt gaagatgtac ccgtccatgc ccgctttctc ccctgggcct      360

ggtatcaagg aagagtcagt gccactgagc atcctgcaga cccccacccc acagcccctg      420

ccaggggccc tcctgccaca gagcttccca gccccagccc caccgcagtt cagctccacc      480

cctgtgttag gctaccccag ccctccggga ggcttctcta caggaagccc tcccgggaac      540

acccagcagc cgctgcctgg cctgccactg gcttccccgc caggggtccc gcccgtctcc      600

ttgcacaccc aggtccagag tgtggtcccc cagcagctac tgacagtcac agctgccccc      660

acggcagccc ctgtaacgac cactgtgacc tcgcagatcc agcaggtccc ggtcctgctg      720

cagccccact tcatcaaggc agactcgctg cttctgacag ccatgaagac agacggagcc      780

actgtgaagg cggcaggtct cagtcccctg gtctctggca ccactgtgca gacagggcct      840

ttgccgaccc tggtgagtgg cggaaccatc ttggcaacag tcccactggt cgtagatgcg      900

gagaagctgc ctatcaaccg gctcgcagct ggcagcaagg ccccggcctc tgcccagagc      960

cgtggagaga agcgcacagc ccacaacgcc attgagaagc gctaccgctc ctccatcaat     1020

gacaaaatca ttgagctcaa ggatctggtg gtgggcactg aggcaaagct gaataaatct     1080

gctgtcttgc gcaaggccat cgactacatt cgctttctgc aacacagcaa ccagaaactc     1140

aagcaggaga acctaagtct gcgcactgct gtccacaaaa gcaaatctct gaaggatctg     1200

gtgtcggcct gtggcagtgg agggaacaca gacgtgctca tggagggcgt gaagactgag     1260

gtggaggaca cactgacccc acccccctcg gatgctggct cacctttcca gagcagcccc     1320

ttgtcccttg gcagcagggg cagtggcagc ggtggcagtg gcagtgactc ggagcctgac     1380

agcccagtct ttgaggacag caaggcaaag ccagagcagc ggccgtctct gcacagccgg     1440

ggcatgctgg accgctcccg cctggccctg tgcacgctcg tcttcctctg cctgtcctgc     1500

aaccccttgg cctccttgct gggggcccgg gggcttccca gcccctcaga taccaccagc     1560

gtctaccata gccctgggcg caacgtgctg ggcaccgaga gcagagatgg ccctggctgg     1620

gcccagtggc tgctgccccc agtggtctgg ctgctcaatg ggctgttggt gctcgtctcc     1680

ttggtgcttc tctttgtcta cggtgagcca gtcacacggc cccactcagg ccccgccgtg     1740

tacttctgga ggcatcgcaa gcaggctgac ctggacctgg cccggggaga ctttgcccag     1800

gctgcccagc agctgtggct ggccctgcgg gcactgggcc ggcccctgcc cacctcccac     1860

ctggacctgg cttgtagcct cctctggaac ctcatccgtc acctgctgca gcgtctctgg     1920

gtgggccgct ggctggcagg ccgggcaggg ggcctgcagc aggactgtgc tctgcgagtg     1980

gatgctagcg ccagcgcccg agacgcagcc ctggtctacc ataagctgca ccagctgcac     2040

accatgggga agcacacagg cgggcacctc actgccacca acctggcgct gagtgccctg     2100

aacctggcag agtgtgcagg ggatgccgtg tctgtggcga cgctggccga gatctatgtg     2160

gcggctgcat tgagagtgaa gaccagtctc ccacgggcct tgcattttct gacacgcttc     2220

ttcctgagca gtgcccgcca ggcctgcctg gcacagagtg gctcagtgcc tcctgccatg     2280

cagtggctct gccaccccgt gggccaccgt ttcttcgtgg atggggactg gtccgtgctc     2340

agtaccccat gggagagcct gtacagcttg gccgggaacc cagtggaccc cctggcccag     2400

gtgactcagc tattccggga acatctctta gagcgagcac tgaactgtgt gacccagccc     2460

aaccccagcc ctgggtcagc tgatggggac aaggaattct cggatgccct cgggtacctg     2520

cagctgctga acagctgttc tgatgctgcg ggggctcctg cctacagctt ctccatcagt     2580

tccagcatgg ccaccaccac cggcgtagac ccggtggcca agtggtgggc ctctctgaca     2640

gctgtggtga tccactggct gcggcgggat gaggaggcgg ctgagcggct gtgcccgctg     2700

gtggagcacc tgccccgggt gctgcaggag tctgagagac ccctgcccag ggcagctctg     2760

cactccttca aggctgcccg ggccctgctg ggctgtgcca aggcagagtc tggtccagcc     2820

agcctgacca tctgtgagaa ggccagtggg tacctgcagg acagcctggc taccacacca     2880

gccagcagct ccattgacaa ggccgtgcag ctgttcctgt gtgacctgct tcttgtggtg     2940

cgcaccagcc tgtggcggca gcagcagccc ccggccccgg ccccagcagc ccagggcacc     3000

agcagcaggc cccaggcttc cgcccttgag ctgcgtggct tccaacggga cctgagcagc     3060

ctgaggcggc tggcacagag cttccggccc gccatgcgga gggtgttcct acatgaggcc     3120

acggcccggc tgatggcggg ggccagcccc acacggacac accagctcct cgaccgcagt     3180

ctgaggcggc gggcaggccc cggtggcaaa ggaggcgcgg tggcggagct ggagccgcgg     3240

cccacgcggc gggagcacgc ggaggccttg ctgctggcct cctgctacct gccccccggc     3300

ttcctgtcgg cgcccgggca gcgcgtgggc atgctggctg aggcggcgcg cacactcgag     3360

aagcttggcg atcgccggct gctgcacgac tgtcagcaga tgctcatgcg cctgggcggt     3420

gggaccactg tcacttccag ctag                                            3444


<210> 69
<211> 138
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Interferon-gamma"

<400> 69
Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn 
1               5                   10                  15      


Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile 
            20                  25                  30          


Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln 
    50                  55                  60                  


Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val Lys 
65                  70                  75                  80  


Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr 
                85                  90                  95      


Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu 
            100                 105                 110         


Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Lys 
        115                 120                 125             


Arg Lys Arg Ser Gln Met Leu Phe Arg Gly 
    130                 135             


<210> 70
<211> 414
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Interferon-gamma"

<400> 70
caggacccat atgtaaaaga agcagaaaac cttaagaaat attttaatgc aggtcattca       60

gatgtagcgg ataatggaac tcttttctta ggcattttga agaattggaa agaggagagt      120

gacagaaaaa taatgcagag ccaaattgtc tccttttact tcaaactttt taaaaacttt      180

aaagatgacc agagcatcca aaagagtgtg gagaccatca aggaagacat gaatgtcaag      240

tttttcaata gcaacaaaaa gaaacgagat gacttcgaaa agctgactaa ttattcggta      300

actgacttga atgtccaacg caaagcaata catgaactca tccaagtgat ggctgaactg      360

tcgccagcag ctaaaacagg gaagcgaaaa aggagtcaga tgctgtttcg aggt            414


<210> 71
<211> 227
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="Granzyme B"

<400> 71
Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg Cys Gly Gly Phe 
            20                  25                  30          


Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser 
        35                  40                  45              


Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Pro 
    50                  55                  60                  


Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro His Pro Ala Tyr 
65                  70                  75                  80  


Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg 
                85                  90                  95      


Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg Leu Pro Ser Asn 
            100                 105                 110         


Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val Ala Gly Trp Gly 
        115                 120                 125             


Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu Gln Glu Val Lys 
    130                 135                 140                 


Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp Leu Arg His Tyr 
145                 150                 155                 160 


Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro Glu Ile Lys Lys 
                165                 170                 175     


Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Lys Val 
            180                 185                 190         


Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly Met Pro Pro Arg 
        195                 200                 205             


Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile Lys Lys Thr Met 
    210                 215                 220                 


Lys Arg Tyr 
225         


<210> 72
<211> 681
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="Granzyme B"

<400> 72
atcatcgggg gacatgaggc caagccccac tcccgcccct acatggctta tcttatgatc       60

tgggatcaga agtctctgaa gaggtgcggt ggcttcctga tacgagacga cttcgtgctg      120

acagctgctc actgttgggg aagctccata aatgtcacct tgggggccca caatatcaaa      180

gaacaggagc cgacccagca gtttatccct gtgaaaagac ccatccccca tccagcctat      240

aatcctaaga acttctccaa cgacatcatg ctactgcagc tggagagaaa ggccaagcgg      300

accagagctg tgcagcccct caggctacct agcaacaagg cccaggtgaa gccagggcag      360

acatgcagtg tggccggctg ggggcagacg gcccccctgg gaaaacactc acacacacta      420

caagaggtga agatgacagt gcaggaagat cgaaagtgcg aatctgactt acgccattat      480

tacgacagta ccattgagtt gtgcgtgggg gacccagaga ttaaaaagac ttcctttaag      540

ggggactctg gaggccctct tgtgtgtaac aaggtggccc agggcattgt ctcctatgga      600

cgaaacaatg gcatgcctcc acgagcctgc accaaagtct caagctttgt acactggata      660

aagaaaacca tgaaacgcta c                                                681


<210> 73
<211> 268
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="PD-1"

<400> 73
Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser 
145                 150                 155                 160 


Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala 
                165                 170                 175     


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
            180                 185                 190         


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
        195                 200                 205             


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
    210                 215                 220                 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
225                 230                 235                 240 


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
                245                 250                 255     


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
            260                 265             


<210> 74
<211> 272
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="PD-L1"

<400> 74
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
    210                 215                 220                 


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
225                 230                 235                 240 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
                245                 250                 255     


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
            260                 265                 270         


<210> 75
<211> 223
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="TIGIT"

<400> 75
Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly Ala Met Ala Ala Thr 
        115                 120                 125             


Leu Val Val Ile Cys Thr Ala Val Ile Val Val Val Ala Leu Thr Arg 
    130                 135                 140                 


Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu Gly Asp Leu Arg Arg 
145                 150                 155                 160 


Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser Ala Pro Ser Pro Pro 
                165                 170                 175     


Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala Gly Leu Cys Gly Glu 
            180                 185                 190         


Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp Tyr Phe Asn Val Leu 
        195                 200                 205             


Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe Thr Glu Thr Gly 
    210                 215                 220             


<210> 76
<211> 311
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="CD1A"

<400> 76
Asn Ala Asp Gly Leu Lys Glu Pro Leu Ser Phe His Val Thr Trp Ile 
1               5                   10                  15      


Ala Ser Phe Tyr Asn His Ser Trp Lys Gln Asn Leu Val Ser Gly Trp 
            20                  25                  30          


Leu Ser Asp Leu Gln Thr His Thr Trp Asp Ser Asn Ser Ser Thr Ile 
        35                  40                  45              


Val Phe Leu Cys Pro Trp Ser Arg Gly Asn Phe Ser Asn Glu Glu Trp 
    50                  55                  60                  


Lys Glu Leu Glu Thr Leu Phe Arg Ile Arg Thr Ile Arg Ser Phe Glu 
65                  70                  75                  80  


Gly Ile Arg Arg Tyr Ala His Glu Leu Gln Phe Glu Tyr Pro Phe Glu 
                85                  90                  95      


Ile Gln Val Thr Gly Gly Cys Glu Leu His Ser Gly Lys Val Ser Gly 
            100                 105                 110         


Ser Phe Leu Gln Leu Ala Tyr Gln Gly Ser Asp Phe Val Ser Phe Gln 
        115                 120                 125             


Asn Asn Ser Trp Leu Pro Tyr Pro Val Ala Gly Asn Met Ala Lys His 
    130                 135                 140                 


Phe Cys Lys Val Leu Asn Gln Asn Gln His Glu Asn Asp Ile Thr His 
145                 150                 155                 160 


Asn Leu Leu Ser Asp Thr Cys Pro Arg Phe Ile Leu Gly Leu Leu Asp 
                165                 170                 175     


Ala Gly Lys Ala His Leu Gln Arg Gln Val Lys Pro Glu Ala Trp Leu 
            180                 185                 190         


Ser His Gly Pro Ser Pro Gly Pro Gly His Leu Gln Leu Val Cys His 
        195                 200                 205             


Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly 
    210                 215                 220                 


Glu Gln Glu Gln Gln Gly Thr Gln Arg Gly Asp Ile Leu Pro Ser Ala 
225                 230                 235                 240 


Asp Gly Thr Trp Tyr Leu Arg Ala Thr Leu Glu Val Ala Ala Gly Glu 
                245                 250                 255     


Ala Ala Asp Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly Gln 
            260                 265                 270         


Asp Ile Val Leu Tyr Trp Glu His His Ser Ser Val Gly Phe Ile Ile 
        275                 280                 285             


Leu Ala Val Ile Val Pro Leu Leu Leu Leu Ile Gly Leu Ala Leu Trp 
    290                 295                 300                 


Phe Arg Lys Arg Cys Phe Cys 
305                 310     


<210> 77
<211> 279
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="TIM3"

<400> 77
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp 
            20                  25                  30          


Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn 
    50                  55                  60                  


Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr 
65                  70                  75                  80  


Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile 
                85                  90                  95      


Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys 
            100                 105                 110         


Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro 
        115                 120                 125             


Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu 
    130                 135                 140                 


Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn 
145                 150                 155                 160 


Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala 
                165                 170                 175     


Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly Ile Cys Ala Gly Leu 
            180                 185                 190         


Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe Lys Trp Tyr Ser His 
        195                 200                 205             


Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile Ser Leu Ala Asn Leu 
    210                 215                 220                 


Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu Gly Ile Arg Ser Glu 
225                 230                 235                 240 


Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Glu Pro 
                245                 250                 255     


Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln Gln Pro Ser Gln Pro 
            260                 265                 270         


Leu Gly Cys Arg Phe Ala Met 
        275                 


<210> 78
<211> 133
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-2"

<400> 78
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210> 79
<211> 152
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-7"

<400> 79
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210> 80
<211> 197
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-12alpha"

<400> 80
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 81
<211> 306
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-12beta"

<400> 81
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210> 82
<211> 114
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-15"

<400> 82
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 83
<211> 133
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-21"

<400> 83
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser 
    130             


<210> 84
<211> 270
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-33"

<400> 84
Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys 
1               5                   10                  15      


Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser 
            20                  25                  30          


Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg 
        35                  40                  45              


Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr 
    50                  55                  60                  


Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu 
65                  70                  75                  80  


Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe 
                85                  90                  95      


Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser 
            100                 105                 110         


Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr 
        115                 120                 125             


Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu 
    130                 135                 140                 


Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu 
145                 150                 155                 160 


Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly 
                165                 170                 175     


Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe 
            180                 185                 190         


Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys 
        195                 200                 205             


Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His 
    210                 215                 220                 


Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile 
225                 230                 235                 240 


Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu 
                245                 250                 255     


Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
            260                 265                 270 


<210> 85
<211> 696
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 85
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys 
145                 150                 155                 160 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
                165                 170                 175     


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
            180                 185                 190         


Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
    210                 215                 220                 


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys 
                245                 250                 255     


Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn 
            260                 265                 270         


Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser 
        275                 280                 285             


Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile 
    290                 295                 300                 


Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro 
305                 310                 315                 320 


Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu 
                325                 330                 335     


Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro 
            340                 345                 350         


Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val 
        355                 360                 365             


Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu 
    370                 375                 380                 


Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys 
385                 390                 395                 400 


Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe 
                405                 410                 415     


Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala 
            420                 425                 430         


Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val 
        435                 440                 445             


Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Val Gln Leu Gln 
    450                 455                 460                 


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
465                 470                 475                 480 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Ile Gln Trp Val 
                485                 490                 495     


Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Ser Ile Asn Pro 
            500                 505                 510         


Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr 
        515                 520                 525             


Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met Glu Phe Ser Ser 
    530                 535                 540                 


Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala Arg Trp Gly Asp 
545                 550                 555                 560 


Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu 
            580                 585                 590         


Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu Arg Val 
        595                 600                 605             


Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Phe His 
    610                 615                 620                 


Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Cys Ile Tyr Ser 
625                 630                 635                 640 


Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly 
                645                 650                 655     


Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala 
            660                 665                 670         


Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro Thr Phe Gly Gly 
        675                 680                 685             


Gly Thr Lys Leu Glu Thr Lys Arg 
    690                 695     


<210> 86
<211> 2088
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 86
cagatcgtgc tgacccaaag ccccgccatc atgagcgcta gccccggtga gaaggtgacc       60

atgacatgct ccgcttccag ctccgtgtcc tacatgaact ggtatcagca gaaaagcgga      120

accagcccca aaaggtggat ctacgacacc agcaagctgg cctccggagt gcccgctcat      180

ttccggggct ctggatccgg caccagctac tctttaacca tttccggcat ggaagctgaa      240

gacgctgcca cctactattg ccagcaatgg agcagcaacc ccttcacatt cggatctggc      300

accaagctcg aaatcaatcg tggaggaggt ggcagcggcg gcggtggatc cggcggagga      360

ggaagccaag ttcaactcca gcagagcggc gctgaactgg cccggcccgg cgcctccgtc      420

aagatgagct gcaaggcttc cggctataca tttactcgtt acacaatgca ttgggtcaag      480

cagaggcccg gtcaaggttt agagtggatc ggatatatca acccttcccg gggctacacc      540

aactataacc aaaagttcaa ggataaagcc actttaacca ctgacaagag ctcctccacc      600

gcctacatgc agctgtcctc tttaaccagc gaggactccg ctgtttacta ctgcgctagg      660

tattacgacg accactactg tttagactat tggggacaag gtaccacttt aaccgtcagc      720

agctccggca ccaccaatac cgtggccgct tataacctca catggaagag caccaacttc      780

aagacaattc tggaatggga acccaagccc gtcaatcaag tttacaccgt gcagatctcc      840

accaaatccg gagactggaa gagcaagtgc ttctacacaa cagacaccga gtgtgattta      900

accgacgaaa tcgtcaagga cgtcaagcaa acctatctgg ctcgggtctt ttcctacccc      960

gctggcaatg tcgagtccac cggctccgct ggcgagcctc tctacgagaa ttcccccgaa     1020

ttcacccctt atttagagac caatttaggc cagcctacca tccagagctt cgagcaagtt     1080

ggcaccaagg tgaacgtcac cgtcgaggat gaaaggactt tagtgcggcg gaataacaca     1140

tttttatccc tccgggatgt gttcggcaaa gacctcatct acacactgta ctattggaag     1200

tccagctcct ccggcaaaaa gaccgctaag accaacacca acgagttttt aattgacgtg     1260

gacaaaggcg agaactactg cttcagcgtg caagccgtga tcccttctcg taccgtcaac     1320

cggaagagca cagattcccc cgttgagtgc atgggccaag aaaagggcga gttccgggag     1380

gtccagctgc agcagagcgg acccgaactc gtgaaacccg gtgcttccgt gaaaatgtct     1440

tgtaaggcca gcggatacac cttcacctcc tatgtgatcc agtgggtcaa acagaagccc     1500

ggacaaggtc tcgagtggat cggcagcatc aacccttaca acgactatac caaatacaac     1560

gagaagttta agggaaaggc tactttaacc tccgacaaaa gctccatcac agcctacatg     1620

gagttcagct ctttaacatc cgaggacagc gctctgtact attgcgcccg gtggggcgac     1680

ggcaattact ggggacgggg cacaacactg accgtgagca gcggaggcgg aggctccggc     1740

ggaggcggat ctggcggtgg cggctccgac atcgagatga cccagtcccc cgctatcatg     1800

tccgcctctt taggcgagcg ggtcacaatg acttgtacag cctcctccag cgtctcctcc     1860

tcctacttcc attggtacca acagaaaccc ggaagctccc ctaaactgtg catctacagc     1920

accagcaatc tcgccagcgg cgtgccccct aggttttccg gaagcggaag caccagctac     1980

tctttaacca tctcctccat ggaggctgag gatgccgcca cctacttttg tcaccagtac     2040

caccggtccc ccaccttcgg aggcggcacc aaactggaga caaagagg                  2088


<210> 87
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 87
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
            20                  25                  30          


Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
        35                  40                  45              


Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp 
    50                  55                  60                  


Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu 
                85                  90                  95      


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
            100                 105                 110         


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met 
145                 150                 155                 160 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp 
                165                 170                 175     


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
            180                 185                 190         


Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
        195                 200                 205             


Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
    210                 215                 220                 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr 
225                 230                 235                 240 


Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
                245                 250                 255     


Val Ser Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr 
            260                 265                 270         


Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro 
        275                 280                 285             


Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp 
    290                 295                 300                 


Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp 
305                 310                 315                 320 


Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser 
                325                 330                 335     


Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu 
            340                 345                 350         


Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly 
        355                 360                 365             


Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val 
    370                 375                 380                 


Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu 
385                 390                 395                 400 


Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr 
                405                 410                 415     


Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn 
            420                 425                 430         


Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val 
        435                 440                 445             


Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser 
    450                 455                 460                 


Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Val Gln 
465                 470                 475                 480 


Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
                485                 490                 495     


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Ile Gln 
            500                 505                 510         


Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Ser Ile 
        515                 520                 525             


Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys 
    530                 535                 540                 


Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met Glu Phe 
545                 550                 555                 560 


Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala Arg Trp 
                565                 570                 575     


Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val Ser Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        595                 600                 605             


Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu 
    610                 615                 620                 


Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr 
625                 630                 635                 640 


Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Cys Ile 
                645                 650                 655     


Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly 
            660                 665                 670         


Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
        675                 680                 685             


Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro Thr Phe 
    690                 695                 700                 


Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg 
705                 710                 


<210> 88
<211> 2142
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 88
atgaagtggg tgaccttcat cagcttatta tttttattca gctccgccta ttcccagatc       60

gtgctgaccc aaagccccgc catcatgagc gctagccccg gtgagaaggt gaccatgaca      120

tgctccgctt ccagctccgt gtcctacatg aactggtatc agcagaaaag cggaaccagc      180

cccaaaaggt ggatctacga caccagcaag ctggcctccg gagtgcccgc tcatttccgg      240

ggctctggat ccggcaccag ctactcttta accatttccg gcatggaagc tgaagacgct      300

gccacctact attgccagca atggagcagc aaccccttca cattcggatc tggcaccaag      360

ctcgaaatca atcgtggagg aggtggcagc ggcggcggtg gatccggcgg aggaggaagc      420

caagttcaac tccagcagag cggcgctgaa ctggcccggc ccggcgcctc cgtcaagatg      480

agctgcaagg cttccggcta tacatttact cgttacacaa tgcattgggt caagcagagg      540

cccggtcaag gtttagagtg gatcggatat atcaaccctt cccggggcta caccaactat      600

aaccaaaagt tcaaggataa agccacttta accactgaca agagctcctc caccgcctac      660

atgcagctgt cctctttaac cagcgaggac tccgctgttt actactgcgc taggtattac      720

gacgaccact actgtttaga ctattgggga caaggtacca ctttaaccgt cagcagctcc      780

ggcaccacca ataccgtggc cgcttataac ctcacatgga agagcaccaa cttcaagaca      840

attctggaat gggaacccaa gcccgtcaat caagtttaca ccgtgcagat ctccaccaaa      900

tccggagact ggaagagcaa gtgcttctac acaacagaca ccgagtgtga tttaaccgac      960

gaaatcgtca aggacgtcaa gcaaacctat ctggctcggg tcttttccta ccccgctggc     1020

aatgtcgagt ccaccggctc cgctggcgag cctctctacg agaattcccc cgaattcacc     1080

ccttatttag agaccaattt aggccagcct accatccaga gcttcgagca agttggcacc     1140

aaggtgaacg tcaccgtcga ggatgaaagg actttagtgc ggcggaataa cacattttta     1200

tccctccggg atgtgttcgg caaagacctc atctacacac tgtactattg gaagtccagc     1260

tcctccggca aaaagaccgc taagaccaac accaacgagt ttttaattga cgtggacaaa     1320

ggcgagaact actgcttcag cgtgcaagcc gtgatccctt ctcgtaccgt caaccggaag     1380

agcacagatt cccccgttga gtgcatgggc caagaaaagg gcgagttccg ggaggtccag     1440

ctgcagcaga gcggacccga actcgtgaaa cccggtgctt ccgtgaaaat gtcttgtaag     1500

gccagcggat acaccttcac ctcctatgtg atccagtggg tcaaacagaa gcccggacaa     1560

ggtctcgagt ggatcggcag catcaaccct tacaacgact ataccaaata caacgagaag     1620

tttaagggaa aggctacttt aacctccgac aaaagctcca tcacagccta catggagttc     1680

agctctttaa catccgagga cagcgctctg tactattgcg cccggtgggg cgacggcaat     1740

tactggggac ggggcacaac actgaccgtg agcagcggag gcggaggctc cggcggaggc     1800

ggatctggcg gtggcggctc cgacatcgag atgacccagt cccccgctat catgtccgcc     1860

tctttaggcg agcgggtcac aatgacttgt acagcctcct ccagcgtctc ctcctcctac     1920

ttccattggt accaacagaa acccggaagc tcccctaaac tgtgcatcta cagcaccagc     1980

aatctcgcca gcggcgtgcc ccctaggttt tccggaagcg gaagcaccag ctactcttta     2040

accatctcct ccatggaggc tgaggatgcc gccacctact tttgtcacca gtaccaccgg     2100

tcccccacct tcggaggcgg caccaaactg gagacaaaga gg                        2142


<210> 89
<211> 696
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 89
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
            20                  25                  30          


Ile Gln Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu 
    130                 135                 140                 


Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser 
145                 150                 155                 160 


Ser Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu 
                165                 170                 175     


Cys Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
        195                 200                 205             


Ala Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg Ser Gly Thr Thr 
225                 230                 235                 240 


Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys 
                245                 250                 255     


Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val 
            260                 265                 270         


Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr 
        275                 280                 285             


Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys 
    290                 295                 300                 


Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu 
305                 310                 315                 320 


Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe 
                325                 330                 335     


Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe 
            340                 345                 350         


Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr 
        355                 360                 365             


Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly 
    370                 375                 380                 


Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly 
385                 390                 395                 400 


Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp 
                405                 410                 415     


Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg 
            420                 425                 430         


Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln 
        435                 440                 445             


Glu Lys Gly Glu Phe Arg Glu Gln Ile Val Leu Thr Gln Ser Pro Ala 
    450                 455                 460                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
465                 470                 475                 480 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                485                 490                 495     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            500                 505                 510         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        515                 520                 525             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    530                 535                 540                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
545                 550                 555                 560 


Asn Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly 
            580                 585                 590         


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
        595                 600                 605             


Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
    610                 615                 620                 


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys 
625                 630                 635                 640 


Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala 
                645                 650                 655     


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
            660                 665                 670         


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
        675                 680                 685             


Gly Thr Thr Leu Thr Val Ser Ser 
    690                 695     


<210> 90
<211> 2088
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 90
gtgcagctgc agcagtccgg acccgaactg gtcaagcccg gtgcctccgt gaaaatgtct       60

tgtaaggctt ctggctacac ctttacctcc tacgtcatcc aatgggtgaa gcagaagccc      120

ggtcaaggtc tcgagtggat cggcagcatc aatccctaca acgattacac caagtataac      180

gaaaagttta agggcaaggc cactctgaca agcgacaaga gctccattac cgcctacatg      240

gagttttcct ctttaacttc tgaggactcc gctttatact attgcgctcg ttggggcgat      300

ggcaattatt ggggccgggg aactacttta acagtgagct ccggcggcgg cggaagcgga      360

ggtggaggat ctggcggtgg aggcagcgac atcgagatga cacagtcccc cgctatcatg      420

agcgcctctt taggagaacg tgtgaccatg acttgtacag cttcctccag cgtgagcagc      480

tcctatttcc actggtacca gcagaaaccc ggctcctccc ctaaactgtg tatctactcc      540

acaagcaatt tagctagcgg cgtgcctcct cgttttagcg gctccggcag cacctcttac      600

tctttaacca ttagctctat ggaggccgaa gatgccgcca catacttttg ccatcagtac      660

caccggtccc ctacctttgg cggaggcaca aagctggaga ccaagcggag cggcaccacc      720

aacacagtgg ccgcctacaa tctgacttgg aaatccacca acttcaagac catcctcgag      780

tgggagccca agcccgttaa tcaagtttat accgtgcaga tttccaccaa gagcggcgac      840

tggaaatcca agtgcttcta taccacagac accgagtgcg atctcaccga cgagatcgtc      900

aaagacgtga agcagacata tttagctagg gtgttctcct accccgctgg aaacgtggag      960

agcaccggat ccgctggaga gcctttatac gagaactccc ccgaattcac cccctatctg     1020

gaaaccaatt taggccagcc caccatccag agcttcgaac aagttggcac aaaggtgaac     1080

gtcaccgtcg aagatgagag gactttagtg cggaggaaca atacattttt atccttacgt     1140

gacgtcttcg gcaaggattt aatctacaca ctgtattact ggaagtctag ctcctccggc     1200

aagaagaccg ccaagaccaa taccaacgaa tttttaattg acgtggacaa gggcgagaac     1260

tactgcttct ccgtgcaagc tgtgatcccc tcccggacag tgaaccggaa gtccaccgac     1320

tcccccgtgg agtgcatggg ccaagagaag ggagagtttc gtgagcagat cgtgctgacc     1380

cagtcccccg ctattatgag cgctagcccc ggtgaaaagg tgactatgac atgcagcgcc     1440

agctcttccg tgagctacat gaactggtat cagcagaagt ccggcaccag ccctaaaagg     1500

tggatctacg acaccagcaa gctggccagc ggcgtccccg ctcactttcg gggctccggc     1560

tccggaacaa gctactctct gaccatcagc ggcatggaag ccgaggatgc cgctacctat     1620

tactgtcagc agtggagctc caaccccttc acctttggat ccggcaccaa gctcgagatt     1680

aatcgtggag gcggaggtag cggaggaggc ggatccggcg gtggaggtag ccaagttcag     1740

ctccagcaaa gcggcgccga actcgctcgg cccggcgctt ccgtgaagat gtcttgtaag     1800

gcctccggct ataccttcac ccggtacaca atgcactggg tcaagcaacg gcccggtcaa     1860

ggtttagagt ggattggcta tatcaacccc tcccggggct ataccaacta caaccagaag     1920

ttcaaggaca aagccaccct caccaccgac aagtccagca gcaccgctta catgcagctg     1980

agctctttaa catccgagga ttccgccgtg tactactgcg ctcggtacta cgacgatcat     2040

tactgcctcg attactgggg ccaaggtacc accttaacag tctcctcc                  2088


<210> 91
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 91
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
            20                  25                  30          


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
        35                  40                  45              


Tyr Val Ile Gln Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp 
    50                  55                  60                  


Ile Gly Ser Ile Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys 
65                  70                  75                  80  


Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala 
                85                  90                  95      


Tyr Met Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Trp Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu 
        115                 120                 125             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala 
145                 150                 155                 160 


Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Ser Ser Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
            180                 185                 190         


Lys Leu Cys Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
    210                 215                 220                 


Met Glu Ala Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg 
225                 230                 235                 240 


Ser Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg Ser Gly 
                245                 250                 255     


Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn 
            260                 265                 270         


Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr 
        275                 280                 285             


Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe 
    290                 295                 300                 


Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp 
305                 310                 315                 320 


Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn 
                325                 330                 335     


Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro 
            340                 345                 350         


Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln 
        355                 360                 365             


Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu 
    370                 375                 380                 


Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val 
385                 390                 395                 400 


Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser 
                405                 410                 415     


Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp 
            420                 425                 430         


Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro 
        435                 440                 445             


Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met 
    450                 455                 460                 


Gly Gln Glu Lys Gly Glu Phe Arg Glu Gln Ile Val Leu Thr Gln Ser 
465                 470                 475                 480 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                485                 490                 495     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
            500                 505                 510         


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
        515                 520                 525             


Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    530                 535                 540                 


Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
545                 550                 555                 560 


Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
                565                 570                 575     


Glu Ile Asn Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
        595                 600                 605             


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    610                 615                 620                 


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
625                 630                 635                 640 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                645                 650                 655     


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
            660                 665                 670         


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
        675                 680                 685             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
    690                 695                 700                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
705                 710                 


<210> 92
<211> 2142
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 92
atgaaatggg tcaccttcat ctctttactg tttttattta gcagcgccta cagcgtgcag       60

ctgcagcagt ccggacccga actggtcaag cccggtgcct ccgtgaaaat gtcttgtaag      120

gcttctggct acacctttac ctcctacgtc atccaatggg tgaagcagaa gcccggtcaa      180

ggtctcgagt ggatcggcag catcaatccc tacaacgatt acaccaagta taacgaaaag      240

tttaagggca aggccactct gacaagcgac aagagctcca ttaccgccta catggagttt      300

tcctctttaa cttctgagga ctccgcttta tactattgcg ctcgttgggg cgatggcaat      360

tattggggcc ggggaactac tttaacagtg agctccggcg gcggcggaag cggaggtgga      420

ggatctggcg gtggaggcag cgacatcgag atgacacagt cccccgctat catgagcgcc      480

tctttaggag aacgtgtgac catgacttgt acagcttcct ccagcgtgag cagctcctat      540

ttccactggt accagcagaa acccggctcc tcccctaaac tgtgtatcta ctccacaagc      600

aatttagcta gcggcgtgcc tcctcgtttt agcggctccg gcagcacctc ttactcttta      660

accattagct ctatggaggc cgaagatgcc gccacatact tttgccatca gtaccaccgg      720

tcccctacct ttggcggagg cacaaagctg gagaccaagc ggagcggcac caccaacaca      780

gtggccgcct acaatctgac ttggaaatcc accaacttca agaccatcct cgagtgggag      840

cccaagcccg ttaatcaagt ttataccgtg cagatttcca ccaagagcgg cgactggaaa      900

tccaagtgct tctataccac agacaccgag tgcgatctca ccgacgagat cgtcaaagac      960

gtgaagcaga catatttagc tagggtgttc tcctaccccg ctggaaacgt ggagagcacc     1020

ggatccgctg gagagccttt atacgagaac tcccccgaat tcacccccta tctggaaacc     1080

aatttaggcc agcccaccat ccagagcttc gaacaagttg gcacaaaggt gaacgtcacc     1140

gtcgaagatg agaggacttt agtgcggagg aacaatacat ttttatcctt acgtgacgtc     1200

ttcggcaagg atttaatcta cacactgtat tactggaagt ctagctcctc cggcaagaag     1260

accgccaaga ccaataccaa cgaattttta attgacgtgg acaagggcga gaactactgc     1320

ttctccgtgc aagctgtgat cccctcccgg acagtgaacc ggaagtccac cgactccccc     1380

gtggagtgca tgggccaaga gaagggagag tttcgtgagc agatcgtgct gacccagtcc     1440

cccgctatta tgagcgctag ccccggtgaa aaggtgacta tgacatgcag cgccagctct     1500

tccgtgagct acatgaactg gtatcagcag aagtccggca ccagccctaa aaggtggatc     1560

tacgacacca gcaagctggc cagcggcgtc cccgctcact ttcggggctc cggctccgga     1620

acaagctact ctctgaccat cagcggcatg gaagccgagg atgccgctac ctattactgt     1680

cagcagtgga gctccaaccc cttcaccttt ggatccggca ccaagctcga gattaatcgt     1740

ggaggcggag gtagcggagg aggcggatcc ggcggtggag gtagccaagt tcagctccag     1800

caaagcggcg ccgaactcgc tcggcccggc gcttccgtga agatgtcttg taaggcctcc     1860

ggctatacct tcacccggta cacaatgcac tgggtcaagc aacggcccgg tcaaggttta     1920

gagtggattg gctatatcaa cccctcccgg ggctatacca actacaacca gaagttcaag     1980

gacaaagcca ccctcaccac cgacaagtcc agcagcaccg cttacatgca gctgagctct     2040

ttaacatccg aggattccgc cgtgtactac tgcgctcggt actacgacga tcattactgc     2100

ctcgattact ggggccaagg taccacctta acagtctcct cc                        2142


<210> 93
<211> 219
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="Tissue factor"

<400> 93
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


<210> 94
<211> 657
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Tissue factor"

<400> 94
agcggcacaa ccaacacagt cgctgcctat aacctcactt ggaagagcac caacttcaaa       60

accatcctcg aatgggaacc caaacccgtt aaccaagttt acaccgtgca gatcagcacc      120

aagtccggcg actggaagtc caaatgtttc tataccaccg acaccgagtg cgatctcacc      180

gatgagatcg tgaaagatgt gaaacagacc tacctcgccc gggtgtttag ctaccccgcc      240

ggcaatgtgg agagcactgg ttccgctggc gagcctttat acgagaacag ccccgaattt      300

accccttacc tcgagaccaa tttaggacag cccaccatcc aaagctttga gcaagttggc      360

acaaaggtga atgtgacagt ggaggacgag cggactttag tgcggcggaa caacaccttt      420

ctcagcctcc gggatgtgtt cggcaaagat ttaatctaca cactgtatta ctggaagtcc      480

tcttcctccg gcaagaagac agctaaaacc aacacaaacg agtttttaat cgacgtggat      540

aaaggcgaaa actactgttt cagcgtgcaa gctgtgatcc cctcccggac cgtgaatagg      600

aaaagcaccg atagccccgt tgagtgcatg ggccaagaaa agggcgagtt ccgggag         657


<210> 95
<211> 223
<212> PRT
<213> Mus musculus  

<220>
<221> source
<223> /note="Tissue factor"

<400> 95
Ala Gly Ile Pro Glu Lys Ala Phe Asn Leu Thr Trp Ile Ser Thr Asp 
1               5                   10                  15      


Phe Lys Thr Ile Leu Glu Trp Gln Pro Lys Pro Thr Asn Tyr Thr Tyr 
            20                  25                  30          


Thr Val Gln Ile Ser Asp Arg Ser Arg Asn Trp Lys Asn Lys Cys Phe 
        35                  40                  45              


Ser Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp 
    50                  55                  60                  


Val Thr Trp Ala Tyr Glu Ala Lys Val Leu Ser Val Pro Arg Arg Asn 
65                  70                  75                  80  


Ser Val His Gly Asp Gly Asp Gln Leu Val Ile His Gly Glu Glu Pro 
                85                  90                  95      


Pro Phe Thr Asn Ala Pro Lys Phe Leu Pro Tyr Arg Asp Thr Asn Leu 
            100                 105                 110         


Gly Gln Pro Val Ile Gln Gln Phe Glu Gln Asp Gly Arg Lys Leu Asn 
        115                 120                 125             


Val Val Val Lys Asp Ser Leu Thr Leu Val Arg Lys Asn Gly Thr Phe 
    130                 135                 140                 


Leu Thr Leu Arg Gln Val Phe Gly Lys Asp Leu Gly Tyr Ile Ile Thr 
145                 150                 155                 160 


Tyr Arg Lys Gly Ser Ser Thr Gly Lys Lys Thr Asn Ile Thr Asn Thr 
                165                 170                 175     


Asn Glu Phe Ser Ile Asp Val Glu Glu Gly Val Ser Tyr Cys Phe Phe 
            180                 185                 190         


Val Gln Ala Met Ile Phe Ser Arg Lys Thr Asn Gln Asn Ser Pro Gly 
        195                 200                 205             


Ser Ser Thr Val Cys Thr Glu Gln Trp Lys Ser Phe Leu Gly Glu 
    210                 215                 220             


<210> 96
<211> 224
<212> PRT
<213> Rattus rattus  

<220>
<221> source
<223> /note="Tissue factor"

<400> 96
Ala Gly Thr Pro Pro Gly Lys Ala Phe Asn Leu Thr Trp Ile Ser Thr 
1               5                   10                  15      


Asp Phe Lys Thr Ile Leu Glu Trp Gln Pro Lys Pro Thr Asn Tyr Thr 
            20                  25                  30          


Tyr Thr Val Gln Ile Ser Asp Arg Ser Arg Asn Trp Lys Tyr Lys Cys 
        35                  40                  45              


Thr Gly Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
    50                  55                  60                  


Asp Val Asn Trp Thr Tyr Glu Ala Arg Val Leu Ser Val Pro Trp Arg 
65                  70                  75                  80  


Asn Ser Thr His Gly Lys Glu Thr Leu Phe Gly Thr His Gly Glu Glu 
                85                  90                  95      


Pro Pro Phe Thr Asn Ala Arg Lys Phe Leu Pro Tyr Arg Asp Thr Lys 
            100                 105                 110         


Ile Gly Gln Pro Val Ile Gln Lys Tyr Glu Gln Gly Gly Thr Lys Leu 
        115                 120                 125             


Lys Val Thr Val Lys Asp Ser Phe Thr Leu Val Arg Lys Asn Gly Thr 
    130                 135                 140                 


Phe Leu Thr Leu Arg Gln Val Phe Gly Asn Asp Leu Gly Tyr Ile Leu 
145                 150                 155                 160 


Thr Tyr Arg Lys Asp Ser Ser Thr Gly Arg Lys Thr Asn Thr Thr His 
                165                 170                 175     


Thr Asn Glu Phe Leu Ile Asp Val Glu Lys Gly Val Ser Tyr Cys Phe 
            180                 185                 190         


Phe Ala Gln Ala Val Ile Phe Ser Arg Lys Thr Asn His Lys Ser Pro 
        195                 200                 205             


Glu Ser Ile Thr Lys Cys Thr Glu Gln Trp Lys Ser Val Leu Gly Glu 
    210                 215                 220                 


<210> 97
<211> 219
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="Tissue factor"

<400> 97
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Ala Thr Ala Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Ala Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Ala Arg Asn Asn Thr Ala Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


<210> 98
<211> 219
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="Tissue factor"

<400> 98
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Ala Thr Ala Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Ala Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Ala Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Ala Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Ala Arg Asn Asn Thr Ala Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


<210> 99
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 99
Gly Gly Gly Ser 
1               


<210> 100
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 100
Gly Gly Gly Gly Ser 
1               5   


<210> 101
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 101
Gly Gly Ser Gly 
1               


<210> 102
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 102
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 103
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 103
ggcggtggag gatccggagg aggtggctcc ggcggcggag gatct                       45


<210> 104
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 104
Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210> 105
<211> 133
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-3"

<400> 105
Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp Val Asn Cys 
1               5                   10                  15      


Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu 
            20                  25                  30          


Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu 
        35                  40                  45              


Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala 
    50                  55                  60                  


Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn 
65                  70                  75                  80  


Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro 
                85                  90                  95      


Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr 
            100                 105                 110         


Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln Thr Thr Leu 
        115                 120                 125             


Ser Leu Ala Ile Phe 
    130             


<210> 106
<211> 79
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-8"

<400> 106
Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys 
1               5                   10                  15      


Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu 
            20                  25                  30          


Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val 
        35                  40                  45              


Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp 
    50                  55                  60                  


Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser 
65                  70                  75                  


<210> 107
<211> 160
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-10"

<400> 107
Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210> 108
<211> 132
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="IL-17"

<400> 108
Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210> 109
<211> 157
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-18"

<400> 109
Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
145                 150                 155         


<210> 110
<211> 352
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="PDGF-DD"

<400> 110
Arg Asp Thr Ser Ala Thr Pro Gln Ser Ala Ser Ile Lys Ala Leu Arg 
1               5                   10                  15      


Asn Ala Asn Leu Arg Arg Asp Glu Ser Asn His Leu Thr Asp Leu Tyr 
            20                  25                  30          


Arg Arg Asp Glu Thr Ile Gln Val Lys Gly Asn Gly Tyr Val Gln Ser 
        35                  40                  45              


Pro Arg Phe Pro Asn Ser Tyr Pro Arg Asn Leu Leu Leu Thr Trp Arg 
    50                  55                  60                  


Leu His Ser Gln Glu Asn Thr Arg Ile Gln Leu Val Phe Asp Asn Gln 
65                  70                  75                  80  


Phe Gly Leu Glu Glu Ala Glu Asn Asp Ile Cys Arg Tyr Asp Phe Val 
                85                  90                  95      


Glu Val Glu Asp Ile Ser Glu Thr Ser Thr Ile Ile Arg Gly Arg Trp 
            100                 105                 110         


Cys Gly His Lys Glu Val Pro Pro Arg Ile Lys Ser Arg Thr Asn Gln 
        115                 120                 125             


Ile Lys Ile Thr Phe Lys Ser Asp Asp Tyr Phe Val Ala Lys Pro Gly 
    130                 135                 140                 


Phe Lys Ile Tyr Tyr Ser Leu Leu Glu Asp Phe Gln Pro Ala Ala Ala 
145                 150                 155                 160 


Ser Glu Thr Asn Trp Glu Ser Val Thr Ser Ser Ile Ser Gly Val Ser 
                165                 170                 175     


Tyr Asn Ser Pro Ser Val Thr Asp Pro Thr Leu Ile Ala Asp Ala Leu 
            180                 185                 190         


Asp Lys Lys Ile Ala Glu Phe Asp Thr Val Glu Asp Leu Leu Lys Tyr 
        195                 200                 205             


Phe Asn Pro Glu Ser Trp Gln Glu Asp Leu Glu Asn Met Tyr Leu Asp 
    210                 215                 220                 


Thr Pro Arg Tyr Arg Gly Arg Ser Tyr His Asp Arg Lys Ser Lys Val 
225                 230                 235                 240 


Asp Leu Asp Arg Leu Asn Asp Asp Ala Lys Arg Tyr Ser Cys Thr Pro 
                245                 250                 255     


Arg Asn Tyr Ser Val Asn Ile Arg Glu Glu Leu Lys Leu Ala Asn Val 
            260                 265                 270         


Val Phe Phe Pro Arg Cys Leu Leu Val Gln Arg Cys Gly Gly Asn Cys 
        275                 280                 285             


Gly Cys Gly Thr Val Asn Trp Arg Ser Cys Thr Cys Asn Ser Gly Lys 
    290                 295                 300                 


Thr Val Lys Lys Tyr His Glu Val Leu Gln Phe Glu Pro Gly His Ile 
305                 310                 315                 320 


Lys Arg Arg Gly Arg Ala Lys Thr Met Ala Leu Val Asp Ile Gln Leu 
                325                 330                 335     


Asp His His Glu Arg Cys Asp Cys Ile Cys Ser Ser Arg Pro Pro Arg 
            340                 345                 350         


<210> 111
<211> 248
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="SCF"

<400> 111
Glu Gly Ile Cys Arg Asn Arg Val Thr Asn Asn Val Lys Asp Val Thr 
1               5                   10                  15      


Lys Leu Val Ala Asn Leu Pro Lys Asp Tyr Met Ile Thr Leu Lys Tyr 
            20                  25                  30          


Val Pro Gly Met Asp Val Leu Pro Ser His Cys Trp Ile Ser Glu Met 
        35                  40                  45              


Val Val Gln Leu Ser Asp Ser Leu Thr Asp Leu Leu Asp Lys Phe Ser 
    50                  55                  60                  


Asn Ile Ser Glu Gly Leu Ser Asn Tyr Ser Ile Ile Asp Lys Leu Val 
65                  70                  75                  80  


Asn Ile Val Asp Asp Leu Val Glu Cys Val Lys Glu Asn Ser Ser Lys 
                85                  90                  95      


Asp Leu Lys Lys Ser Phe Lys Ser Pro Glu Pro Arg Leu Phe Thr Pro 
            100                 105                 110         


Glu Glu Phe Phe Arg Ile Phe Asn Arg Ser Ile Asp Ala Phe Lys Asp 
        115                 120                 125             


Phe Val Val Ala Ser Glu Thr Ser Asp Cys Val Val Ser Ser Thr Leu 
    130                 135                 140                 


Ser Pro Glu Lys Asp Ser Arg Val Ser Val Thr Lys Pro Phe Met Leu 
145                 150                 155                 160 


Pro Pro Val Ala Ala Ser Ser Leu Arg Asn Asp Ser Ser Ser Ser Asn 
                165                 170                 175     


Arg Lys Ala Lys Asn Pro Pro Gly Asp Ser Ser Leu His Trp Ala Ala 
            180                 185                 190         


Met Ala Leu Pro Ala Leu Phe Ser Leu Ile Ile Gly Phe Ala Phe Gly 
        195                 200                 205             


Ala Leu Tyr Trp Lys Lys Arg Gln Pro Ser Leu Thr Arg Ala Val Glu 
    210                 215                 220                 


Asn Ile Gln Ile Asn Glu Glu Asp Asn Glu Ile Ser Met Leu Gln Glu 
225                 230                 235                 240 


Lys Glu Arg Glu Phe Gln Glu Val 
                245             


<210> 112
<211> 209
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="FLT3L"

<400> 112
Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu 
145                 150                 155                 160 


Leu Leu Leu Leu Leu Leu Pro Val Gly Leu Leu Leu Leu Ala Ala Ala 
                165                 170                 175     


Trp Cys Leu His Trp Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly 
            180                 185                 190         


Glu Gln Val Pro Pro Val Pro Ser Pro Gln Asp Leu Leu Leu Val Glu 
        195                 200                 205             


His 
    


<210> 113
<211> 65
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL15Ralpha"

<400> 113
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg 
65  


<210> 114
<211> 195
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL15Ralpha"

<400> 114
attacatgcc cccctcccat gagcgtggag cacgccgaca tctgggtgaa gagctatagc       60

ctctacagcc gggagaggta tatctgtaac agcggcttca agaggaaggc cggcaccagc      120

agcctcaccg agtgcgtgct gaataaggct accaacgtgg ctcactggac aacaccctct      180

ttaaagtgca tccgg                                                       195


<210> 115
<211> 114
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="IL-15"

<400> 115
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 116
<211> 342
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="IL-15"

<400> 116
aactgggtga acgtcatcag cgatttaaag aagatcgaag atttaattca gtccatgcat       60

atcgacgcca ctttatacac agaatccgac gtgcacccct cttgtaaggt gaccgccatg      120

aaatgttttt tactggagct gcaagttatc tctttagaga gcggagacgc tagcatccac      180

gacaccgtgg agaatttaat cattttagcc aataactctt tatccagcaa cggcaacgtg      240

acagagtccg gctgcaagga gtgcgaagag ctggaggaga agaacatcaa ggagtttctg      300

caatcctttg tgcacattgt ccagatgttc atcaatacct cc                         342


<210> 117
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 117
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210> 118
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 118
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctcc             54


<210> 119
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 119
atgaagtggg tcacatttat ctctttactg ttcctcttct ccagcgccta cagc             54


<210> 120
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 120
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctcc             54


<210> 121
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 121
Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Leu Gly Val Asn Cys 
1               5                   10                  15      


<210> 122
<211> 58
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 122
Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly 
    50                  55              


<210> 123
<211> 97
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 123
Met Pro Asn His Gln Ser Gly Ser Pro Thr Gly Ser Ser Asp Leu Leu 
1               5                   10                  15      


Leu Ser Gly Lys Lys Gln Arg Pro His Leu Ala Leu Arg Arg Lys Arg 
            20                  25                  30          


Arg Arg Glu Met Arg Lys Ile Asn Arg Lys Val Arg Arg Met Asn Leu 
        35                  40                  45              


Ala Pro Ile Lys Glu Lys Thr Ala Trp Gln His Leu Gln Ala Leu Ile 
    50                  55                  60                  


Ser Glu Ala Glu Glu Val Leu Lys Thr Ser Gln Thr Pro Gln Asn Ser 
65                  70                  75                  80  


Leu Thr Leu Phe Leu Ala Leu Leu Ser Val Leu Gly Pro Pro Val Thr 
                85                  90                  95      


Gly 
    


<210> 124
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 124
Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Cys Gln Gly Val Val Ser 
            20                  25                  30  


<210> 125
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 125
Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Leu Gly Val Asn Cys 
1               5                   10                  15      


<210> 126
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 126
Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210> 127
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 127
Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210> 128
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 128
Glu Glu Glu Glu Glu Glu 
1               5       


<210> 129
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 129
Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210> 130
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 130
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 131
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 131
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 132
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 132
His His His His His 
1               5   


<210> 133
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 133
His His His His His His 
1               5       


<210> 134
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 134
His His His His His His His 
1               5           


<210> 135
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 135
His His His His His His His His 
1               5               


<210> 136
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 136
His His His His His His His His His 
1               5                   


<210> 137
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 137
His His His His His His His His His His 
1               5                   10  


<210> 138
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 138
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 139
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 139
Thr Lys Glu Asn Pro Arg Ser Asn Gln Glu Glu Ser Tyr Asp Asp Asn 
1               5                   10                  15      


Glu Ser 
        


<210> 140
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 140
Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210> 141
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 141
Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210> 142
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 142
Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210> 143
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 143
Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210> 144
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 144
Pro Asp Arg Val Arg Ala Val Ser His Trp Ser Ser 
1               5                   10          


<210> 145
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 145
Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210> 146
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 146
Cys Cys Pro Gly Cys Cys 
1               5       


<210> 147
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-7s sequence"

<400> 147
Glu Val His Thr Asn Gln Asp Pro Leu Asp 
1               5                   10  


<210> 148
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 148
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210> 149
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 149
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210> 150
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 150
Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210> 151
<211> 241
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="CD3"

<400> 151
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys 
145                 150                 155                 160 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
                165                 170                 175     


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
            180                 185                 190         


Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
    210                 215                 220                 


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210> 152
<211> 723
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD3"

<400> 152
cagatcgtgc tgacccaaag ccccgccatc atgagcgcta gccccggtga gaaggtgacc       60

atgacatgct ccgcttccag ctccgtgtcc tacatgaact ggtatcagca gaaaagcgga      120

accagcccca aaaggtggat ctacgacacc agcaagctgg cctccggagt gcccgctcat      180

ttccggggct ctggatccgg caccagctac tctttaacca tttccggcat ggaagctgaa      240

gacgctgcca cctactattg ccagcaatgg agcagcaacc ccttcacatt cggatctggc      300

accaagctcg aaatcaatcg tggaggaggt ggcagcggcg gcggtggatc cggcggagga      360

ggaagccaag ttcaactcca gcagagcggc gctgaactgg cccggcccgg cgcctccgtc      420

aagatgagct gcaaggcttc cggctataca tttactcgtt acacaatgca ttgggtcaag      480

cagaggcccg gtcaaggttt agagtggatc ggatatatca acccttcccg gggctacacc      540

aactataacc aaaagttcaa ggataaagcc actttaacca ctgacaagag ctcctccacc      600

gcctacatgc agctgtcctc tttaaccagc gaggactccg ctgtttacta ctgcgctagg      660

tattacgacg accactactg tttagactat tggggacaag gtaccacttt aaccgtcagc      720

agc                                                                    723


<210> 153
<211> 236
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD28"

<400> 153
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
            20                  25                  30          


Ile Gln Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu 
    130                 135                 140                 


Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser 
145                 150                 155                 160 


Ser Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu 
                165                 170                 175     


Cys Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
        195                 200                 205             


Ala Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg 
225                 230                 235     


<210> 154
<211> 708
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="CD28"

<400> 154
gtccagctgc agcagagcgg acccgaactc gtgaaacccg gtgcttccgt gaaaatgtct       60

tgtaaggcca gcggatacac cttcacctcc tatgtgatcc agtgggtcaa acagaagccc      120

ggacaaggtc tcgagtggat cggcagcatc aacccttaca acgactatac caaatacaac      180

gagaagttta agggaaaggc tactttaacc tccgacaaaa gctccatcac agcctacatg      240

gagttcagct ctttaacatc cgaggacagc gctctgtact attgcgcccg gtggggcgac      300

ggcaattact ggggacgggg cacaacactg accgtgagca gcggaggcgg aggctccggc      360

ggaggcggat ctggcggtgg cggctccgac atcgagatga cccagtcccc cgctatcatg      420

tccgcctctt taggcgagcg ggtcacaatg acttgtacag cctcctccag cgtctcctcc      480

tcctacttcc attggtacca acagaaaccc ggaagctccc ctaaactgtg catctacagc      540

accagcaatc tcgccagcgg cgtgccccct aggttttccg gaagcggaag caccagctac      600

tctttaacca tctcctccat ggaggctgag gatgccgcca cctacttttg tcaccagtac      660

caccggtccc ccaccttcgg aggcggcacc aaactggaga caaagagg                   708


<210> 155
<211> 696
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      3t28 sequence"

<400> 155
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys 
145                 150                 155                 160 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
                165                 170                 175     


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
            180                 185                 190         


Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
    210                 215                 220                 


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys 
                245                 250                 255     


Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn 
            260                 265                 270         


Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser 
        275                 280                 285             


Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile 
    290                 295                 300                 


Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro 
305                 310                 315                 320 


Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu 
                325                 330                 335     


Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro 
            340                 345                 350         


Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val 
        355                 360                 365             


Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu 
    370                 375                 380                 


Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys 
385                 390                 395                 400 


Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe 
                405                 410                 415     


Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala 
            420                 425                 430         


Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val 
        435                 440                 445             


Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Val Gln Leu Gln 
    450                 455                 460                 


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
465                 470                 475                 480 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Ile Gln Trp Val 
                485                 490                 495     


Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Ser Ile Asn Pro 
            500                 505                 510         


Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr 
        515                 520                 525             


Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met Glu Phe Ser Ser 
    530                 535                 540                 


Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala Arg Trp Gly Asp 
545                 550                 555                 560 


Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu 
            580                 585                 590         


Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu Arg Val 
        595                 600                 605             


Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Phe His 
    610                 615                 620                 


Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Cys Ile Tyr Ser 
625                 630                 635                 640 


Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly 
                645                 650                 655     


Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala 
            660                 665                 670         


Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro Thr Phe Gly Gly 
        675                 680                 685             


Gly Thr Lys Leu Glu Thr Lys Arg 
    690                 695     


<210> 156
<211> 2088
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      3t28 sequence"

<400> 156
cagatcgtgc tgacccaaag ccccgccatc atgagcgcta gccccggtga gaaggtgacc       60

atgacatgct ccgcttccag ctccgtgtcc tacatgaact ggtatcagca gaaaagcgga      120

accagcccca aaaggtggat ctacgacacc agcaagctgg cctccggagt gcccgctcat      180

ttccggggct ctggatccgg caccagctac tctttaacca tttccggcat ggaagctgaa      240

gacgctgcca cctactattg ccagcaatgg agcagcaacc ccttcacatt cggatctggc      300

accaagctcg aaatcaatcg tggaggaggt ggcagcggcg gcggtggatc cggcggagga      360

ggaagccaag ttcaactcca gcagagcggc gctgaactgg cccggcccgg cgcctccgtc      420

aagatgagct gcaaggcttc cggctataca tttactcgtt acacaatgca ttgggtcaag      480

cagaggcccg gtcaaggttt agagtggatc ggatatatca acccttcccg gggctacacc      540

aactataacc aaaagttcaa ggataaagcc actttaacca ctgacaagag ctcctccacc      600

gcctacatgc agctgtcctc tttaaccagc gaggactccg ctgtttacta ctgcgctagg      660

tattacgacg accactactg tttagactat tggggacaag gtaccacttt aaccgtcagc      720

agctccggca ccaccaatac cgtggccgct tataacctca catggaagag caccaacttc      780

aagacaattc tggaatggga acccaagccc gtcaatcaag tttacaccgt gcagatctcc      840

accaaatccg gagactggaa gagcaagtgc ttctacacaa cagacaccga gtgtgattta      900

accgacgaaa tcgtcaagga cgtcaagcaa acctatctgg ctcgggtctt ttcctacccc      960

gctggcaatg tcgagtccac cggctccgct ggcgagcctc tctacgagaa ttcccccgaa     1020

ttcacccctt atttagagac caatttaggc cagcctacca tccagagctt cgagcaagtt     1080

ggcaccaagg tgaacgtcac cgtcgaggat gaaaggactt tagtgcggcg gaataacaca     1140

tttttatccc tccgggatgt gttcggcaaa gacctcatct acacactgta ctattggaag     1200

tccagctcct ccggcaaaaa gaccgctaag accaacacca acgagttttt aattgacgtg     1260

gacaaaggcg agaactactg cttcagcgtg caagccgtga tcccttctcg taccgtcaac     1320

cggaagagca cagattcccc cgttgagtgc atgggccaag aaaagggcga gttccgggag     1380

gtccagctgc agcagagcgg acccgaactc gtgaaacccg gtgcttccgt gaaaatgtct     1440

tgtaaggcca gcggatacac cttcacctcc tatgtgatcc agtgggtcaa acagaagccc     1500

ggacaaggtc tcgagtggat cggcagcatc aacccttaca acgactatac caaatacaac     1560

gagaagttta agggaaaggc tactttaacc tccgacaaaa gctccatcac agcctacatg     1620

gagttcagct ctttaacatc cgaggacagc gctctgtact attgcgcccg gtggggcgac     1680

ggcaattact ggggacgggg cacaacactg accgtgagca gcggaggcgg aggctccggc     1740

ggaggcggat ctggcggtgg cggctccgac atcgagatga cccagtcccc cgctatcatg     1800

tccgcctctt taggcgagcg ggtcacaatg acttgtacag cctcctccag cgtctcctcc     1860

tcctacttcc attggtacca acagaaaccc ggaagctccc ctaaactgtg catctacagc     1920

accagcaatc tcgccagcgg cgtgccccct aggttttccg gaagcggaag caccagctac     1980

tctttaacca tctcctccat ggaggctgag gatgccgcca cctacttttg tcaccagtac     2040

caccggtccc ccaccttcgg aggcggcacc aaactggaga caaagagg                  2088


<210> 157
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      3t28 sequence"

<400> 157
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
            20                  25                  30          


Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
        35                  40                  45              


Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp 
    50                  55                  60                  


Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu 
                85                  90                  95      


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
            100                 105                 110         


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met 
145                 150                 155                 160 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp 
                165                 170                 175     


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
            180                 185                 190         


Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
        195                 200                 205             


Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
    210                 215                 220                 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr 
225                 230                 235                 240 


Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
                245                 250                 255     


Val Ser Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr 
            260                 265                 270         


Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro 
        275                 280                 285             


Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp 
    290                 295                 300                 


Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp 
305                 310                 315                 320 


Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser 
                325                 330                 335     


Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu 
            340                 345                 350         


Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly 
        355                 360                 365             


Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val 
    370                 375                 380                 


Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu 
385                 390                 395                 400 


Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr 
                405                 410                 415     


Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn 
            420                 425                 430         


Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val 
        435                 440                 445             


Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser 
    450                 455                 460                 


Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Val Gln 
465                 470                 475                 480 


Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
                485                 490                 495     


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Ile Gln 
            500                 505                 510         


Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Ser Ile 
        515                 520                 525             


Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys 
    530                 535                 540                 


Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met Glu Phe 
545                 550                 555                 560 


Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala Arg Trp 
                565                 570                 575     


Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val Ser Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        595                 600                 605             


Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu 
    610                 615                 620                 


Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr 
625                 630                 635                 640 


Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Cys Ile 
                645                 650                 655     


Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly 
            660                 665                 670         


Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
        675                 680                 685             


Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro Thr Phe 
    690                 695                 700                 


Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg 
705                 710                 


<210> 158
<211> 2142
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      3t28 sequence"

<400> 158
atgaagtggg tgaccttcat cagcttatta tttttattca gctccgccta ttcccagatc       60

gtgctgaccc aaagccccgc catcatgagc gctagccccg gtgagaaggt gaccatgaca      120

tgctccgctt ccagctccgt gtcctacatg aactggtatc agcagaaaag cggaaccagc      180

cccaaaaggt ggatctacga caccagcaag ctggcctccg gagtgcccgc tcatttccgg      240

ggctctggat ccggcaccag ctactcttta accatttccg gcatggaagc tgaagacgct      300

gccacctact attgccagca atggagcagc aaccccttca cattcggatc tggcaccaag      360

ctcgaaatca atcgtggagg aggtggcagc ggcggcggtg gatccggcgg aggaggaagc      420

caagttcaac tccagcagag cggcgctgaa ctggcccggc ccggcgcctc cgtcaagatg      480

agctgcaagg cttccggcta tacatttact cgttacacaa tgcattgggt caagcagagg      540

cccggtcaag gtttagagtg gatcggatat atcaaccctt cccggggcta caccaactat      600

aaccaaaagt tcaaggataa agccacttta accactgaca agagctcctc caccgcctac      660

atgcagctgt cctctttaac cagcgaggac tccgctgttt actactgcgc taggtattac      720

gacgaccact actgtttaga ctattgggga caaggtacca ctttaaccgt cagcagctcc      780

ggcaccacca ataccgtggc cgcttataac ctcacatgga agagcaccaa cttcaagaca      840

attctggaat gggaacccaa gcccgtcaat caagtttaca ccgtgcagat ctccaccaaa      900

tccggagact ggaagagcaa gtgcttctac acaacagaca ccgagtgtga tttaaccgac      960

gaaatcgtca aggacgtcaa gcaaacctat ctggctcggg tcttttccta ccccgctggc     1020

aatgtcgagt ccaccggctc cgctggcgag cctctctacg agaattcccc cgaattcacc     1080

ccttatttag agaccaattt aggccagcct accatccaga gcttcgagca agttggcacc     1140

aaggtgaacg tcaccgtcga ggatgaaagg actttagtgc ggcggaataa cacattttta     1200

tccctccggg atgtgttcgg caaagacctc atctacacac tgtactattg gaagtccagc     1260

tcctccggca aaaagaccgc taagaccaac accaacgagt ttttaattga cgtggacaaa     1320

ggcgagaact actgcttcag cgtgcaagcc gtgatccctt ctcgtaccgt caaccggaag     1380

agcacagatt cccccgttga gtgcatgggc caagaaaagg gcgagttccg ggaggtccag     1440

ctgcagcaga gcggacccga actcgtgaaa cccggtgctt ccgtgaaaat gtcttgtaag     1500

gccagcggat acaccttcac ctcctatgtg atccagtggg tcaaacagaa gcccggacaa     1560

ggtctcgagt ggatcggcag catcaaccct tacaacgact ataccaaata caacgagaag     1620

tttaagggaa aggctacttt aacctccgac aaaagctcca tcacagccta catggagttc     1680

agctctttaa catccgagga cagcgctctg tactattgcg cccggtgggg cgacggcaat     1740

tactggggac ggggcacaac actgaccgtg agcagcggag gcggaggctc cggcggaggc     1800

ggatctggcg gtggcggctc cgacatcgag atgacccagt cccccgctat catgtccgcc     1860

tctttaggcg agcgggtcac aatgacttgt acagcctcct ccagcgtctc ctcctcctac     1920

ttccattggt accaacagaa acccggaagc tcccctaaac tgtgcatcta cagcaccagc     1980

aatctcgcca gcggcgtgcc ccctaggttt tccggaagcg gaagcaccag ctactcttta     2040

accatctcct ccatggaggc tgaggatgcc gccacctact tttgtcacca gtaccaccgg     2100

tcccccacct tcggaggcgg caccaaactg gagacaaaga gg                        2142


<210> 159
<211> 399
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-2"

<400> 159
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct tttgtcaaag catcatctca acactaact                             399


<210> 160
<211> 399
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-2"

<400> 160
gcccccacct cctcctccac caagaagacc cagctgcagc tggagcattt actgctggat       60

ttacagatga ttttaaacgg catcaacaac tacaagaacc ccaagctgac tcgtatgctg      120

accttcaagt tctacatgcc caagaaggcc accgagctga agcatttaca gtgtttagag      180

gaggagctga agcccctcga ggaggtgctg aatttagccc agtccaagaa tttccattta      240

aggccccggg atttaatcag caacatcaac gtgatcgttt tagagctgaa gggctccgag      300

accaccttca tgtgcgagta cgccgacgag accgccacca tcgtggagtt tttaaatcgt      360

tggatcacct tctgccagtc catcatctcc actttaacc                             399


<210> 161
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      2t2 sequence"

<400> 161
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn 
    130                 135                 140                 


Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro 
145                 150                 155                 160 


Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly 
                165                 170                 175     


Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu 
            180                 185                 190         


Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val 
        195                 200                 205             


Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu 
    210                 215                 220                 


Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn 
225                 230                 235                 240 


Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val 
                245                 250                 255     


Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr 
            260                 265                 270         


Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu 
        275                 280                 285             


Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn 
    290                 295                 300                 


Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe 
305                 310                 315                 320 


Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr 
                325                 330                 335     


Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
            340                 345                 350         


Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
        355                 360                 365             


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
    370                 375                 380                 


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
385                 390                 395                 400 


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
                405                 410                 415     


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
            420                 425                 430         


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
        435                 440                 445             


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
    450                 455                 460                 


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
465                 470                 475                 480 


Ile Ser Thr Leu Thr 
                485 


<210> 162
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      2t2 sequence"

<400> 162
gcccccacct cctcctccac caagaagacc cagctgcagc tggagcattt actgctggat       60

ttacagatga ttttaaacgg catcaacaac tacaagaacc ccaagctgac tcgtatgctg      120

accttcaagt tctacatgcc caagaaggcc accgagctga agcatttaca gtgtttagag      180

gaggagctga agcccctcga ggaggtgctg aatttagccc agtccaagaa tttccattta      240

aggccccggg atttaatcag caacatcaac gtgatcgttt tagagctgaa gggctccgag      300

accaccttca tgtgcgagta cgccgacgag accgccacca tcgtggagtt tttaaatcgt      360

tggatcacct tctgccagtc catcatctcc actttaacca gcggcacaac caacacagtc      420

gctgcctata acctcacttg gaagagcacc aacttcaaaa ccatcctcga atgggaaccc      480

aaacccgtta accaagttta caccgtgcag atcagcacca agtccggcga ctggaagtcc      540

aaatgtttct ataccaccga caccgagtgc gatctcaccg atgagatcgt gaaagatgtg      600

aaacagacct acctcgcccg ggtgtttagc taccccgccg gcaatgtgga gagcactggt      660

tccgctggcg agcctttata cgagaacagc cccgaattta ccccttacct cgagaccaat      720

ttaggacagc ccaccatcca aagctttgag caagttggca caaaggtgaa tgtgacagtg      780

gaggacgagc ggactttagt gcggcggaac aacacctttc tcagcctccg ggatgtgttc      840

ggcaaagatt taatctacac actgtattac tggaagtcct cttcctccgg caagaagaca      900

gctaaaacca acacaaacga gtttttaatc gacgtggata aaggcgaaaa ctactgtttc      960

agcgtgcaag ctgtgatccc ctcccggacc gtgaatagga aaagcaccga tagccccgtt     1020

gagtgcatgg gccaagaaaa gggcgagttc cgggaggcac ctacttcaag ttctacaaag     1080

aaaacacagc tacaactgga gcatttactg ctggatttac agatgatttt gaatggaatt     1140

aataattaca agaatcccaa actcaccagg atgctcacat ttaagtttta catgcccaag     1200

aaggccacag aactgaaaca tcttcagtgt ctagaagaag aactcaaacc tctggaggaa     1260

gtgctaaatt tagctcaaag caaaaacttt cacttaagac ccagggactt aatcagcaat     1320

atcaacgtaa tagttctgga actaaaggga tctgaaacaa cattcatgtg tgaatatgct     1380

gatgagacag caaccattgt agaatttctg aacagatgga ttaccttttg tcaaagcatc     1440

atctcaacac taact                                                      1455


<210> 163
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      2t2 sequence"

<400> 163
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
            20                  25                  30          


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
        35                  40                  45              


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
    50                  55                  60                  


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
65                  70                  75                  80  


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
                85                  90                  95      


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
            100                 105                 110         


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
        115                 120                 125             


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
    130                 135                 140                 


Ser Ile Ile Ser Thr Leu Thr Ser Gly Thr Thr Asn Thr Val Ala Ala 
145                 150                 155                 160 


Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp 
                165                 170                 175     


Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys 
            180                 185                 190         


Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys 
        195                 200                 205             


Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala 
    210                 215                 220                 


Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala 
225                 230                 235                 240 


Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu 
                245                 250                 255     


Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr 
            260                 265                 270         


Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn 
        275                 280                 285             


Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr 
    290                 295                 300                 


Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys 
305                 310                 315                 320 


Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr 
                325                 330                 335     


Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys 
            340                 345                 350         


Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe 
        355                 360                 365             


Arg Glu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
    370                 375                 380                 


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
385                 390                 395                 400 


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
                405                 410                 415     


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
            420                 425                 430         


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
        435                 440                 445             


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
    450                 455                 460                 


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
465                 470                 475                 480 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
                485                 490                 495     


Ser Ile Ile Ser Thr Leu Thr 
            500             


<210> 164
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      2t2 sequence"

<400> 164
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccgccccc       60

acctcctcct ccaccaagaa gacccagctg cagctggagc atttactgct ggatttacag      120

atgattttaa acggcatcaa caactacaag aaccccaagc tgactcgtat gctgaccttc      180

aagttctaca tgcccaagaa ggccaccgag ctgaagcatt tacagtgttt agaggaggag      240

ctgaagcccc tcgaggaggt gctgaattta gcccagtcca agaatttcca tttaaggccc      300

cgggatttaa tcagcaacat caacgtgatc gttttagagc tgaagggctc cgagaccacc      360

ttcatgtgcg agtacgccga cgagaccgcc accatcgtgg agtttttaaa tcgttggatc      420

accttctgcc agtccatcat ctccacttta accagcggca caaccaacac agtcgctgcc      480

tataacctca cttggaagag caccaacttc aaaaccatcc tcgaatggga acccaaaccc      540

gttaaccaag tttacaccgt gcagatcagc accaagtccg gcgactggaa gtccaaatgt      600

ttctatacca ccgacaccga gtgcgatctc accgatgaga tcgtgaaaga tgtgaaacag      660

acctacctcg cccgggtgtt tagctacccc gccggcaatg tggagagcac tggttccgct      720

ggcgagcctt tatacgagaa cagccccgaa tttacccctt acctcgagac caatttagga      780

cagcccacca tccaaagctt tgagcaagtt ggcacaaagg tgaatgtgac agtggaggac      840

gagcggactt tagtgcggcg gaacaacacc tttctcagcc tccgggatgt gttcggcaaa      900

gatttaatct acacactgta ttactggaag tcctcttcct ccggcaagaa gacagctaaa      960

accaacacaa acgagttttt aatcgacgtg gataaaggcg aaaactactg tttcagcgtg     1020

caagctgtga tcccctcccg gaccgtgaat aggaaaagca ccgatagccc cgttgagtgc     1080

atgggccaag aaaagggcga gttccgggag gcacctactt caagttctac aaagaaaaca     1140

cagctacaac tggagcattt actgctggat ttacagatga ttttgaatgg aattaataat     1200

tacaagaatc ccaaactcac caggatgctc acatttaagt tttacatgcc caagaaggcc     1260

acagaactga aacatcttca gtgtctagaa gaagaactca aacctctgga ggaagtgcta     1320

aatttagctc aaagcaaaaa ctttcactta agacccaggg acttaatcag caatatcaac     1380

gtaatagttc tggaactaaa gggatctgaa acaacattca tgtgtgaata tgctgatgag     1440

acagcaacca ttgtagaatt tctgaacaga tggattacct tttgtcaaag catcatctca     1500

acactaact                                                             1509


<210> 165
<211> 342
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="IL-15"

<400> 165
aactgggtga acgtgatcag cgatttaaag aagatcgagg atttaatcca gagcatgcac       60

atcgacgcca ctctgtacac tgagagcgac gtgcacccta gctgcaaggt gactgccatg      120

aagtgctttt tactggagct gcaagttatc tctttagaga gcggcgatgc cagcatccac      180

gacactgtgg agaatttaat cattttagcc aacaactctt taagcagcaa cggcaacgtg      240

acagagagcg gctgcaagga gtgcgaggag ctggaggaga agaacatcaa ggagttttta      300

cagagcttcg tgcacatcgt gcagatgttc atcaacacta gc                         342


<210> 166
<211> 342
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="IL-15"

<400> 166
aactgggtga acgtcatcag cgatttaaag aagatcgaag atttaattca gtccatgcat       60

atcgacgcca ctttatacac agaatccgac gtgcacccct cttgtaaggt gaccgccatg      120

aaatgttttt tactggagct gcaagttatc tctttagaga gcggagacgc tagcatccac      180

gacaccgtgg agaatttaat cattttagcc aataactctt tatccagcaa cggcaacgtg      240

acagagtccg gctgcaagga gtgcgaagag ctggaggaga agaacatcaa ggagtttctg      300

caatcctttg tgcacattgt ccagatgttc atcaatacct cc                         342


<210> 167
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      15t15 sequence"

<400> 167
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp 
        115                 120                 125             


Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val 
    130                 135                 140                 


Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys 
145                 150                 155                 160 


Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu 
                165                 170                 175     


Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr 
            180                 185                 190         


Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr 
        195                 200                 205             


Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln 
    210                 215                 220                 


Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr 
225                 230                 235                 240 


Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser 
                245                 250                 255     


Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp 
            260                 265                 270         


Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu 
        275                 280                 285             


Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln 
    290                 295                 300                 


Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro 
305                 310                 315                 320 


Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val 
                325                 330                 335     


Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met 
            340                 345                 350         


His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys 
        355                 360                 365             


Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser 
    370                 375                 380                 


Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile 
385                 390                 395                 400 


Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser 
                405                 410                 415     


Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe 
            420                 425                 430         


Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
        435                 440                 445         


<210> 168
<211> 1341
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      15t15 sequence"

<400> 168
aactgggtga acgtgatcag cgatttaaag aagatcgagg atttaatcca gagcatgcac       60

atcgacgcca ctctgtacac tgagagcgac gtgcacccta gctgcaaggt gactgccatg      120

aagtgctttt tactggagct gcaagttatc tctttagaga gcggcgatgc cagcatccac      180

gacactgtgg agaatttaat cattttagcc aacaactctt taagcagcaa cggcaacgtg      240

acagagagcg gctgcaagga gtgcgaggag ctggaggaga agaacatcaa ggagttttta      300

cagagcttcg tgcacatcgt gcagatgttc atcaacacta gcagcggcac aaccaacaca      360

gtcgctgcct ataacctcac ttggaagagc accaacttca aaaccatcct cgaatgggaa      420

cccaaacccg ttaaccaagt ttacaccgtg cagatcagca ccaagtccgg cgactggaag      480

tccaaatgtt tctataccac cgacaccgag tgcgatctca ccgatgagat cgtgaaagat      540

gtgaaacaga cctacctcgc ccgggtgttt agctaccccg ccggcaatgt ggagagcact      600

ggttccgctg gcgagccttt atacgagaac agccccgaat ttacccctta cctcgagacc      660

aatttaggac agcccaccat ccaaagcttt gagcaagttg gcacaaaggt gaatgtgaca      720

gtggaggacg agcggacttt agtgcggcgg aacaacacct ttctcagcct ccgggatgtg      780

ttcggcaaag atttaatcta cacactgtat tactggaagt cctcttcctc cggcaagaag      840

acagctaaaa ccaacacaaa cgagttttta atcgacgtgg ataaaggcga aaactactgt      900

ttcagcgtgc aagctgtgat cccctcccgg accgtgaata ggaaaagcac cgatagcccc      960

gttgagtgca tgggccaaga aaagggcgag ttccgggaga actgggtgaa cgtcatcagc     1020

gatttaaaga agatcgaaga tttaattcag tccatgcata tcgacgccac tttatacaca     1080

gaatccgacg tgcacccctc ttgtaaggtg accgccatga aatgtttttt actggagctg     1140

caagttatct ctttagagag cggagacgct agcatccacg acaccgtgga gaatttaatc     1200

attttagcca ataactcttt atccagcaac ggcaacgtga cagagtccgg ctgcaaggag     1260

tgcgaagagc tggaggagaa gaacatcaag gagtttctgc aatcctttgt gcacattgtc     1320

cagatgttca tcaatacctc c                                               1341


<210> 169
<211> 465
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      15t15 sequence"

<400> 169
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu 
    130                 135                 140                 


Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys 
145                 150                 155                 160 


Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp 
                165                 170                 175     


Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr 
            180                 185                 190         


Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe 
        195                 200                 205             


Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro 
    210                 215                 220                 


Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu 
225                 230                 235                 240 


Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn 
                245                 250                 255     


Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe 
            260                 265                 270         


Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr 
        275                 280                 285             


Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr 
    290                 295                 300                 


Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser 
305                 310                 315                 320 


Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp 
                325                 330                 335     


Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn 
            340                 345                 350         


Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln 
        355                 360                 365             


Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro 
    370                 375                 380                 


Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val 
385                 390                 395                 400 


Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn 
                405                 410                 415     


Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr 
            420                 425                 430         


Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys 
        435                 440                 445             


Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr 
    450                 455                 460                 


Ser 
465 


<210> 170
<211> 1395
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      15t15 sequence"

<400> 170
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccaactgg       60

gtgaacgtga tcagcgattt aaagaagatc gaggatttaa tccagagcat gcacatcgac      120

gccactctgt acactgagag cgacgtgcac cctagctgca aggtgactgc catgaagtgc      180

tttttactgg agctgcaagt tatctcttta gagagcggcg atgccagcat ccacgacact      240

gtggagaatt taatcatttt agccaacaac tctttaagca gcaacggcaa cgtgacagag      300

agcggctgca aggagtgcga ggagctggag gagaagaaca tcaaggagtt tttacagagc      360

ttcgtgcaca tcgtgcagat gttcatcaac actagcagcg gcacaaccaa cacagtcgct      420

gcctataacc tcacttggaa gagcaccaac ttcaaaacca tcctcgaatg ggaacccaaa      480

cccgttaacc aagtttacac cgtgcagatc agcaccaagt ccggcgactg gaagtccaaa      540

tgtttctata ccaccgacac cgagtgcgat ctcaccgatg agatcgtgaa agatgtgaaa      600

cagacctacc tcgcccgggt gtttagctac cccgccggca atgtggagag cactggttcc      660

gctggcgagc ctttatacga gaacagcccc gaatttaccc cttacctcga gaccaattta      720

ggacagccca ccatccaaag ctttgagcaa gttggcacaa aggtgaatgt gacagtggag      780

gacgagcgga ctttagtgcg gcggaacaac acctttctca gcctccggga tgtgttcggc      840

aaagatttaa tctacacact gtattactgg aagtcctctt cctccggcaa gaagacagct      900

aaaaccaaca caaacgagtt tttaatcgac gtggataaag gcgaaaacta ctgtttcagc      960

gtgcaagctg tgatcccctc ccggaccgtg aataggaaaa gcaccgatag ccccgttgag     1020

tgcatgggcc aagaaaaggg cgagttccgg gagaactggg tgaacgtcat cagcgattta     1080

aagaagatcg aagatttaat tcagtccatg catatcgacg ccactttata cacagaatcc     1140

gacgtgcacc cctcttgtaa ggtgaccgcc atgaaatgtt ttttactgga gctgcaagtt     1200

atctctttag agagcggaga cgctagcatc cacgacaccg tggagaattt aatcatttta     1260

gccaataact ctttatccag caacggcaac gtgacagagt ccggctgcaa ggagtgcgaa     1320

gagctggagg agaagaacat caaggagttt ctgcaatcct ttgtgcacat tgtccagatg     1380

ttcatcaata cctcc                                                      1395


<210> 171
<211> 471
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-18"

<400> 171
tacttcggca aactggaatc caagctgagc gtgatccgga atttaaacga ccaagttctg       60

tttatcgatc aaggtaaccg gcctctgttc gaggacatga ccgactccga ttgccgggac      120

aatgcccccc ggaccatctt cattatctcc atgtacaagg acagccagcc ccggggcatg      180

gctgtgacaa ttagcgtgaa gtgtgagaaa atcagcactt tatcttgtga gaacaagatc      240

atctccttta aggaaatgaa cccccccgat aacatcaagg acaccaagtc cgatatcatc      300

ttcttccagc ggtccgtgcc cggtcacgat aacaagatgc agttcgaatc ctcctcctac      360

gagggctact ttttagcttg tgaaaaggag agggatttat tcaagctgat cctcaagaag      420

gaggacgagc tgggcgatcg ttccatcatg ttcaccgtcc aaaacgagga t               471


<210> 172
<211> 918
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="IL12Beta"

<400> 172
atttgggaac tgaagaagga cgtctacgtg gtcgaactgg actggtatcc cgatgctccc       60

ggcgaaatgg tggtgctcac ttgtgacacc cccgaagaag acggcatcac ttggaccctc      120

gatcagagca gcgaggtgct gggctccgga aagaccctca caatccaagt taaggagttc      180

ggagacgctg gccaatacac atgccacaag ggaggcgagg tgctcagcca ttccttatta      240

ttattacaca agaaggaaga cggaatctgg tccaccgaca ttttaaaaga tcagaaggag      300

cccaagaata agaccttttt aaggtgtgag gccaaaaact acagcggtcg tttcacttgt      360

tggtggctga ccaccatttc caccgattta accttctccg tgaaaagcag ccggggaagc      420

tccgaccctc aaggtgtgac atgtggagcc gctaccctca gcgctgagag ggttcgtggc      480

gataacaagg aatacgagta cagcgtggag tgccaagaag atagcgcttg tcccgctgcc      540

gaagaatctt tacccattga ggtgatggtg gacgccgtgc acaaactcaa gtacgagaac      600

tacacctcct ccttctttat ccgggacatc attaagcccg atcctcctaa gaatttacag      660

ctgaagcctc tcaaaaatag ccggcaagtt gaggtctctt gggaatatcc cgacacttgg      720

agcacacccc acagctactt ctctttaacc ttttgtgtgc aagttcaagg taaaagcaag      780

cgggagaaga aagaccgggt gtttaccgac aaaaccagcg ccaccgtcat ctgtcggaag      840

aacgcctcca tcagcgtgag ggctcaagat cgttattact ccagcagctg gtccgagtgg      900

gccagcgtgc cttgttcc                                                    918


<210> 173
<211> 591
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="IL-12alpha"

<400> 173
cgtaacctcc ccgtggctac ccccgatccc ggaatgttcc cttgtttaca ccacagccag       60

aatttactga gggccgtgag caacatgctg cagaaagcta ggcagacttt agaattttac      120

ccttgcacca gcgaggagat cgaccatgaa gatatcacca aggacaagac atccaccgtg      180

gaggcttgtt tacctctgga gctgacaaag aacgagtctt gtctcaactc tcgtgaaacc      240

agcttcatca caaatggctc ttgtttagct tcccggaaga cctcctttat gatggcttta      300

tgcctcagct ccatctacga ggatttaaag atgtaccaag tggagttcaa gaccatgaac      360

gccaagctgc tcatggaccc taaacggcag atctttttag accagaacat gctggctgtg      420

attgatgagc tgatgcaagc tttaaacttc aactccgaga ccgtccctca gaagtcctcc      480

ctcgaggagc ccgattttta caagacaaag atcaaactgt gcattttact ccacgccttt      540

aggatccggg ccgtgaccat tgaccgggtc atgagctatt taaacgccag c               591


<210> 174
<211> 490
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 174
Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Ser Gly Thr 
145                 150                 155                 160 


Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe 
                165                 170                 175     


Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr 
            180                 185                 190         


Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr 
        195                 200                 205             


Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val 
    210                 215                 220                 


Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val 
225                 230                 235                 240 


Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu 
                245                 250                 255     


Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser 
            260                 265                 270         


Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg 
        275                 280                 285             


Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe 
    290                 295                 300                 


Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser 
305                 310                 315                 320 


Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val 
                325                 330                 335     


Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser 
            340                 345                 350         


Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly 
        355                 360                 365             


Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp 
    370                 375                 380                 


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
385                 390                 395                 400 


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
                405                 410                 415     


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
            420                 425                 430         


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
        435                 440                 445             


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
    450                 455                 460                 


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
465                 470                 475                 480 


His Ile Val Gln Met Phe Ile Asn Thr Ser 
                485                 490 


<210> 175
<211> 1470
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 175
tacttcggca aactggaatc caagctgagc gtgatccgga atttaaacga ccaagttctg       60

tttatcgatc aaggtaaccg gcctctgttc gaggacatga ccgactccga ttgccgggac      120

aatgcccccc ggaccatctt cattatctcc atgtacaagg acagccagcc ccggggcatg      180

gctgtgacaa ttagcgtgaa gtgtgagaaa atcagcactt tatcttgtga gaacaagatc      240

atctccttta aggaaatgaa cccccccgat aacatcaagg acaccaagtc cgatatcatc      300

ttcttccagc ggtccgtgcc cggtcacgat aacaagatgc agttcgaatc ctcctcctac      360

gagggctact ttttagcttg tgaaaaggag agggatttat tcaagctgat cctcaagaag      420

gaggacgagc tgggcgatcg ttccatcatg ttcaccgtcc aaaacgagga tagcggcaca      480

accaacacag tcgctgccta taacctcact tggaagagca ccaacttcaa aaccatcctc      540

gaatgggaac ccaaacccgt taaccaagtt tacaccgtgc agatcagcac caagtccggc      600

gactggaagt ccaaatgttt ctataccacc gacaccgagt gcgatctcac cgatgagatc      660

gtgaaagatg tgaaacagac ctacctcgcc cgggtgttta gctaccccgc cggcaatgtg      720

gagagcactg gttccgctgg cgagccttta tacgagaaca gccccgaatt taccccttac      780

ctcgagacca atttaggaca gcccaccatc caaagctttg agcaagttgg cacaaaggtg      840

aatgtgacag tggaggacga gcggacttta gtgcggcgga acaacacctt tctcagcctc      900

cgggatgtgt tcggcaaaga tttaatctac acactgtatt actggaagtc ctcttcctcc      960

ggcaagaaga cagctaaaac caacacaaac gagtttttaa tcgacgtgga taaaggcgaa     1020

aactactgtt tcagcgtgca agctgtgatc ccctcccgga ccgtgaatag gaaaagcacc     1080

gatagccccg ttgagtgcat gggccaagaa aagggcgagt tccgggagaa ctgggtgaac     1140

gtcatcagcg atttaaagaa gatcgaagat ttaattcagt ccatgcatat cgacgccact     1200

ttatacacag aatccgacgt gcacccctct tgtaaggtga ccgccatgaa atgtttttta     1260

ctggagctgc aagttatctc tttagagagc ggagacgcta gcatccacga caccgtggag     1320

aatttaatca ttttagccaa taactcttta tccagcaacg gcaacgtgac agagtccggc     1380

tgcaaggagt gcgaagagct ggaggagaag aacatcaagg agtttctgca atcctttgtg     1440

cacattgtcc agatgttcat caatacctcc                                      1470


<210> 176
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 176
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn 
            20                  25                  30          


Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe 
        35                  40                  45              


Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile 
    50                  55                  60                  


Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val 
65                  70                  75                  80  


Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn 
                85                  90                  95      


Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp 
            100                 105                 110         


Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp 
        115                 120                 125             


Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala 
    130                 135                 140                 


Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp 
145                 150                 155                 160 


Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Ser 
                165                 170                 175     


Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr 
            180                 185                 190         


Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val 
        195                 200                 205             


Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys 
    210                 215                 220                 


Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
225                 230                 235                 240 


Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly 
                245                 250                 255     


Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser 
            260                 265                 270         


Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile 
        275                 280                 285             


Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp 
    290                 295                 300                 


Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp 
305                 310                 315                 320 


Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser 
                325                 330                 335     


Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile 
            340                 345                 350         


Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile 
        355                 360                 365             


Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys 
    370                 375                 380                 


Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile 
385                 390                 395                 400 


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
                405                 410                 415     


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
            420                 425                 430         


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
        435                 440                 445             


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
    450                 455                 460                 


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
465                 470                 475                 480 


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
                485                 490                 495     


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            500                 505             


<210> 177
<211> 1524
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 177
atgaagtggg tcacatttat ctctttactg ttcctcttct ccagcgccta cagctacttc       60

ggcaaactgg aatccaagct gagcgtgatc cggaatttaa acgaccaagt tctgtttatc      120

gatcaaggta accggcctct gttcgaggac atgaccgact ccgattgccg ggacaatgcc      180

ccccggacca tcttcattat ctccatgtac aaggacagcc agccccgggg catggctgtg      240

acaattagcg tgaagtgtga gaaaatcagc actttatctt gtgagaacaa gatcatctcc      300

tttaaggaaa tgaacccccc cgataacatc aaggacacca agtccgatat catcttcttc      360

cagcggtccg tgcccggtca cgataacaag atgcagttcg aatcctcctc ctacgagggc      420

tactttttag cttgtgaaaa ggagagggat ttattcaagc tgatcctcaa gaaggaggac      480

gagctgggcg atcgttccat catgttcacc gtccaaaacg aggatagcgg cacaaccaac      540

acagtcgctg cctataacct cacttggaag agcaccaact tcaaaaccat cctcgaatgg      600

gaacccaaac ccgttaacca agtttacacc gtgcagatca gcaccaagtc cggcgactgg      660

aagtccaaat gtttctatac caccgacacc gagtgcgatc tcaccgatga gatcgtgaaa      720

gatgtgaaac agacctacct cgcccgggtg tttagctacc ccgccggcaa tgtggagagc      780

actggttccg ctggcgagcc tttatacgag aacagccccg aatttacccc ttacctcgag      840

accaatttag gacagcccac catccaaagc tttgagcaag ttggcacaaa ggtgaatgtg      900

acagtggagg acgagcggac tttagtgcgg cggaacaaca cctttctcag cctccgggat      960

gtgttcggca aagatttaat ctacacactg tattactgga agtcctcttc ctccggcaag     1020

aagacagcta aaaccaacac aaacgagttt ttaatcgacg tggataaagg cgaaaactac     1080

tgtttcagcg tgcaagctgt gatcccctcc cggaccgtga ataggaaaag caccgatagc     1140

cccgttgagt gcatgggcca agaaaagggc gagttccggg agaactgggt gaacgtcatc     1200

agcgatttaa agaagatcga agatttaatt cagtccatgc atatcgacgc cactttatac     1260

acagaatccg acgtgcaccc ctcttgtaag gtgaccgcca tgaaatgttt tttactggag     1320

ctgcaagtta tctctttaga gagcggagac gctagcatcc acgacaccgt ggagaattta     1380

atcattttag ccaataactc tttatccagc aacggcaacg tgacagagtc cggctgcaag     1440

gagtgcgaag agctggagga gaagaacatc aaggagtttc tgcaatcctt tgtgcacatt     1500

gtccagatgt tcatcaatac ctcc                                            1524


<210> 178
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 178
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
        515                 520                 525             


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
    530                 535                 540                 


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
545                 550                 555                 560 


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                565                 570                 575     


Pro Ser Leu Lys Cys Ile Arg 
            580             


<210> 179
<211> 1749
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 179
atttgggaac tgaagaagga cgtctacgtg gtcgaactgg actggtatcc cgatgctccc       60

ggcgaaatgg tggtgctcac ttgtgacacc cccgaagaag acggcatcac ttggaccctc      120

gatcagagca gcgaggtgct gggctccgga aagaccctca caatccaagt taaggagttc      180

ggagacgctg gccaatacac atgccacaag ggaggcgagg tgctcagcca ttccttatta      240

ttattacaca agaaggaaga cggaatctgg tccaccgaca ttttaaaaga tcagaaggag      300

cccaagaata agaccttttt aaggtgtgag gccaaaaact acagcggtcg tttcacttgt      360

tggtggctga ccaccatttc caccgattta accttctccg tgaaaagcag ccggggaagc      420

tccgaccctc aaggtgtgac atgtggagcc gctaccctca gcgctgagag ggttcgtggc      480

gataacaagg aatacgagta cagcgtggag tgccaagaag atagcgcttg tcccgctgcc      540

gaagaatctt tacccattga ggtgatggtg gacgccgtgc acaaactcaa gtacgagaac      600

tacacctcct ccttctttat ccgggacatc attaagcccg atcctcctaa gaatttacag      660

ctgaagcctc tcaaaaatag ccggcaagtt gaggtctctt gggaatatcc cgacacttgg      720

agcacacccc acagctactt ctctttaacc ttttgtgtgc aagttcaagg taaaagcaag      780

cgggagaaga aagaccgggt gtttaccgac aaaaccagcg ccaccgtcat ctgtcggaag      840

aacgcctcca tcagcgtgag ggctcaagat cgttattact ccagcagctg gtccgagtgg      900

gccagcgtgc cttgttccgg cggtggagga tccggaggag gtggctccgg cggcggagga      960

tctcgtaacc tccccgtggc tacccccgat cccggaatgt tcccttgttt acaccacagc     1020

cagaatttac tgagggccgt gagcaacatg ctgcagaaag ctaggcagac tttagaattt     1080

tacccttgca ccagcgagga gatcgaccat gaagatatca ccaaggacaa gacatccacc     1140

gtggaggctt gtttacctct ggagctgaca aagaacgagt cttgtctcaa ctctcgtgaa     1200

accagcttca tcacaaatgg ctcttgttta gcttcccgga agacctcctt tatgatggct     1260

ttatgcctca gctccatcta cgaggattta aagatgtacc aagtggagtt caagaccatg     1320

aacgccaagc tgctcatgga ccctaaacgg cagatctttt tagaccagaa catgctggct     1380

gtgattgatg agctgatgca agctttaaac ttcaactccg agaccgtccc tcagaagtcc     1440

tccctcgagg agcccgattt ttacaagaca aagatcaaac tgtgcatttt actccacgcc     1500

tttaggatcc gggccgtgac cattgaccgg gtcatgagct atttaaacgc cagcattaca     1560

tgcccccctc ccatgagcgt ggagcacgcc gacatctggg tgaagagcta tagcctctac     1620

agccgggaga ggtatatctg taacagcggc ttcaagagga aggccggcac cagcagcctc     1680

accgagtgcg tgctgaataa ggctaccaac gtggctcact ggacaacacc ctctttaaag     1740

tgcatccgg                                                             1749


<210> 180
<211> 601
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 180
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp 
            20                  25                  30          


Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr 
        35                  40                  45              


Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val 
    50                  55                  60                  


Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp 
65                  70                  75                  80  


Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser 
                85                  90                  95      


Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile 
            100                 105                 110         


Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu 
        115                 120                 125             


Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile 
    130                 135                 140                 


Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp 
145                 150                 155                 160 


Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val 
                165                 170                 175     


Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp 
            180                 185                 190         


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val 
        195                 200                 205             


Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
    210                 215                 220                 


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
            260                 265                 270         


Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp 
        275                 280                 285             


Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val 
    290                 295                 300                 


Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
305                 310                 315                 320 


Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            340                 345                 350         


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        355                 360                 365             


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    370                 375                 380                 


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
385                 390                 395                 400 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                405                 410                 415     


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            420                 425                 430         


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
        435                 440                 445             


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    450                 455                 460                 


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
465                 470                 475                 480 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                485                 490                 495     


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            500                 505                 510         


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        515                 520                 525             


Val Met Ser Tyr Leu Asn Ala Ser Ile Thr Cys Pro Pro Pro Met Ser 
    530                 535                 540                 


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
545                 550                 555                 560 


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
                565                 570                 575     


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
            580                 585                 590         


Thr Thr Pro Ser Leu Lys Cys Ile Arg 
        595                 600     


<210> 181
<211> 1803
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 181
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctccatttgg       60

gaactgaaga aggacgtcta cgtggtcgaa ctggactggt atcccgatgc tcccggcgaa      120

atggtggtgc tcacttgtga cacccccgaa gaagacggca tcacttggac cctcgatcag      180

agcagcgagg tgctgggctc cggaaagacc ctcacaatcc aagttaagga gttcggagac      240

gctggccaat acacatgcca caagggaggc gaggtgctca gccattcctt attattatta      300

cacaagaagg aagacggaat ctggtccacc gacattttaa aagatcagaa ggagcccaag      360

aataagacct ttttaaggtg tgaggccaaa aactacagcg gtcgtttcac ttgttggtgg      420

ctgaccacca tttccaccga tttaaccttc tccgtgaaaa gcagccgggg aagctccgac      480

cctcaaggtg tgacatgtgg agccgctacc ctcagcgctg agagggttcg tggcgataac      540

aaggaatacg agtacagcgt ggagtgccaa gaagatagcg cttgtcccgc tgccgaagaa      600

tctttaccca ttgaggtgat ggtggacgcc gtgcacaaac tcaagtacga gaactacacc      660

tcctccttct ttatccggga catcattaag cccgatcctc ctaagaattt acagctgaag      720

cctctcaaaa atagccggca agttgaggtc tcttgggaat atcccgacac ttggagcaca      780

ccccacagct acttctcttt aaccttttgt gtgcaagttc aaggtaaaag caagcgggag      840

aagaaagacc gggtgtttac cgacaaaacc agcgccaccg tcatctgtcg gaagaacgcc      900

tccatcagcg tgagggctca agatcgttat tactccagca gctggtccga gtgggccagc      960

gtgccttgtt ccggcggtgg aggatccgga ggaggtggct ccggcggcgg aggatctcgt     1020

aacctccccg tggctacccc cgatcccgga atgttccctt gtttacacca cagccagaat     1080

ttactgaggg ccgtgagcaa catgctgcag aaagctaggc agactttaga attttaccct     1140

tgcaccagcg aggagatcga ccatgaagat atcaccaagg acaagacatc caccgtggag     1200

gcttgtttac ctctggagct gacaaagaac gagtcttgtc tcaactctcg tgaaaccagc     1260

ttcatcacaa atggctcttg tttagcttcc cggaagacct cctttatgat ggctttatgc     1320

ctcagctcca tctacgagga tttaaagatg taccaagtgg agttcaagac catgaacgcc     1380

aagctgctca tggaccctaa acggcagatc tttttagacc agaacatgct ggctgtgatt     1440

gatgagctga tgcaagcttt aaacttcaac tccgagaccg tccctcagaa gtcctccctc     1500

gaggagcccg atttttacaa gacaaagatc aaactgtgca ttttactcca cgcctttagg     1560

atccgggccg tgaccattga ccgggtcatg agctatttaa acgccagcat tacatgcccc     1620

cctcccatga gcgtggagca cgccgacatc tgggtgaaga gctatagcct ctacagccgg     1680

gagaggtata tctgtaacag cggcttcaag aggaaggccg gcaccagcag cctcaccgag     1740

tgcgtgctga ataaggctac caacgtggct cactggacaa caccctcttt aaagtgcatc     1800

cgg                                                                   1803


<210> 182
<211> 399
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-21"

<400> 182
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcc                             399


<210> 183
<211> 136
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 183
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135     


<210> 184
<211> 136
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 184
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135     


<210> 185
<211> 408
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 185
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcacgatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgat                   408


<210> 186
<211> 408
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 186
attcctcccc acgtgcagaa gagcgtgaat aatgacatga tcgtgaccga taacaatggc       60

gccgtgaaat ttccccagct gtgcaaattc tgcgatgtga ggttttccac ctgcgacaac      120

cagaagtcct gtatgagcaa ctgcacaatc acctccatct gtgagaagcc tcaggaggtg      180

tgcgtggctg tctggcggaa gaatgacgag aatatcaccc tggaaaccgt ctgccacgat      240

cccaagctgc cctaccacga tttcatcctg gaagacgccg ccagccctaa gtgcatcatg      300

aaagagaaaa agaagcctgg cgagaccttt ttcatgtgct cctgcagcag cgacgaatgc      360

aacgacaata tcatctttag cgaggaatac aataccagca accccgac                   408


<210> 187
<211> 861
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 187
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcacgatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgcaca      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga c                                                861


<210> 188
<211> 287
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 188
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
        275                 280                 285         


<210> 189
<211> 466
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 189
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn 
    130                 135                 140                 


Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro 
145                 150                 155                 160 


Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly 
                165                 170                 175     


Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu 
            180                 185                 190         


Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val 
        195                 200                 205             


Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu 
    210                 215                 220                 


Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn 
225                 230                 235                 240 


Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val 
                245                 250                 255     


Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr 
            260                 265                 270         


Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu 
        275                 280                 285             


Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn 
    290                 295                 300                 


Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe 
305                 310                 315                 320 


Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr 
                325                 330                 335     


Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
            340                 345                 350         


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
        355                 360                 365             


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
    370                 375                 380                 


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
385                 390                 395                 400 


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
                405                 410                 415     


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
            420                 425                 430         


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
        435                 440                 445             


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
    450                 455                 460                 


Thr Ser 
465     


<210> 190
<211> 1398
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 190
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcct ccggcaccac caataccgtg      420

gccgcttata acctcacatg gaagagcacc aacttcaaga caattctgga atgggaaccc      480

aagcccgtca atcaagttta caccgtgcag atctccacca aatccggaga ctggaagagc      540

aagtgcttct acacaacaga caccgagtgt gatttaaccg acgaaatcgt caaggacgtc      600

aagcaaacct atctggctcg ggtcttttcc taccccgctg gcaatgtcga gtccaccggc      660

tccgctggcg agcctctcta cgagaattcc cccgaattca ccccttattt agagaccaat      720

ttaggccagc ctaccatcca gagcttcgag caagttggca ccaaggtgaa cgtcaccgtc      780

gaggatgaaa ggactttagt gcggcggaat aacacatttt tatccctccg ggatgtgttc      840

ggcaaagacc tcatctacac actgtactat tggaagtcca gctcctccgg caaaaagacc      900

gctaagacca acaccaacga gtttttaatt gacgtggaca aaggcgagaa ctactgcttc      960

agcgtgcaag ccgtgatccc ttctcgtacc gtcaaccgga agagcacaga ttcccccgtt     1020

gagtgcatgg gccaagaaaa gggcgagttc cgggagaact gggtgaacgt catcagcgat     1080

ttaaagaaga tcgaagattt aattcagtcc atgcatatcg acgccacttt atacacagaa     1140

tccgacgtgc acccctcttg taaggtgacc gccatgaaat gttttttact ggagctgcaa     1200

gttatctctt tagagagcgg agacgctagc atccacgaca ccgtggagaa tttaatcatt     1260

ttagccaata actctttatc cagcaacggc aacgtgacag agtccggctg caaggagtgc     1320

gaagagctgg aggagaagaa catcaaggag tttctgcaat cctttgtgca cattgtccag     1380

atgttcatca atacctcc                                                   1398


<210> 191
<211> 484
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 191
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ser Gly Thr Thr Asn Thr Val Ala Ala 
145                 150                 155                 160 


Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp 
                165                 170                 175     


Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys 
            180                 185                 190         


Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys 
        195                 200                 205             


Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala 
    210                 215                 220                 


Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala 
225                 230                 235                 240 


Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu 
                245                 250                 255     


Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr 
            260                 265                 270         


Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn 
        275                 280                 285             


Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr 
    290                 295                 300                 


Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys 
305                 310                 315                 320 


Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr 
                325                 330                 335     


Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys 
            340                 345                 350         


Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe 
        355                 360                 365             


Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
    370                 375                 380                 


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
385                 390                 395                 400 


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
                405                 410                 415     


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
            420                 425                 430         


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
        435                 440                 445             


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
    450                 455                 460                 


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
465                 470                 475                 480 


Ile Asn Thr Ser 
                


<210> 192
<211> 1452
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 192
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tcctccggca ccaccaatac cgtggccgct      480

tataacctca catggaagag caccaacttc aagacaattc tggaatggga acccaagccc      540

gtcaatcaag tttacaccgt gcagatctcc accaaatccg gagactggaa gagcaagtgc      600

ttctacacaa cagacaccga gtgtgattta accgacgaaa tcgtcaagga cgtcaagcaa      660

acctatctgg ctcgggtctt ttcctacccc gctggcaatg tcgagtccac cggctccgct      720

ggcgagcctc tctacgagaa ttcccccgaa ttcacccctt atttagagac caatttaggc      780

cagcctacca tccagagctt cgagcaagtt ggcaccaagg tgaacgtcac cgtcgaggat      840

gaaaggactt tagtgcggcg gaataacaca tttttatccc tccgggatgt gttcggcaaa      900

gacctcatct acacactgta ctattggaag tccagctcct ccggcaaaaa gaccgctaag      960

accaacacca acgagttttt aattgacgtg gacaaaggcg agaactactg cttcagcgtg     1020

caagccgtga tcccttctcg taccgtcaac cggaagagca cagattcccc cgttgagtgc     1080

atgggccaag aaaagggcga gttccgggag aactgggtga acgtcatcag cgatttaaag     1140

aagatcgaag atttaattca gtccatgcat atcgacgcca ctttatacac agaatccgac     1200

gtgcacccct cttgtaaggt gaccgccatg aaatgttttt tactggagct gcaagttatc     1260

tctttagaga gcggagacgc tagcatccac gacaccgtgg agaatttaat cattttagcc     1320

aataactctt tatccagcaa cggcaacgtg acagagtccg gctgcaagga gtgcgaagag     1380

ctggaggaga agaacatcaa ggagtttctg caatcctttg tgcacattgt ccagatgttc     1440

atcaatacct cc                                                         1452


<210> 193
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 193
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile 
        275                 280                 285             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    290                 295                 300                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
305                 310                 315                 320 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                325                 330                 335     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            340                 345                 350         


<210> 194
<211> 1056
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 194
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcacgatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgcaca      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga catcacgtgt cctcctccta tgtccgtgga acacgcagac      900

atctgggtca agagctacag cttgtactcc agggagcggt acatttgtaa ctctggtttc      960

aagcgtaaag ccggcacgtc cagcctgacg gagtgcgtgt tgaacaaggc cacgaatgtc     1020

gcccactgga caacccccag tctcaaatgt attaga                               1056


<210> 195
<211> 370
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 195
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg 
    370 


<210> 196
<211> 1110
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 196
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcac gatcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg cacaatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacatcac gtgtcctcct cctatgtccg tggaacacgc agacatctgg      960

gtcaagagct acagcttgta ctccagggag cggtacattt gtaactctgg tttcaagcgt     1020

aaagccggca cgtccagcct gacggagtgc gtgttgaaca aggccacgaa tgtcgcccac     1080

tggacaaccc ccagtctcaa atgtattaga                                      1110


<210> 197
<211> 399
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL21"

<400> 197
caaggtcaag atcgccacat gattagaatg cgtcaactta tagatattgt tgatcagctg       60

aaaaattatg tgaatgactt ggtccctgaa tttctgccag ctccagaaga tgtagagaca      120

aactgtgagt ggtcagcttt ttcctgtttt cagaaggccc aactaaagtc agcaaataca      180

ggaaacaatg aaaggataat caatgtatca attaaaaagc tgaagaggaa accaccttcc      240

acaaatgcag ggagaagaca gaaacacaga ctaacatgcc cttcatgtga ttcttatgag      300

aaaaaaccac ccaaagaatt cctagaaaga ttcaaatcac ttctccaaaa gatgattcat      360

cagcatctgt cctctagaac acacggaagt gaagattcc                             399


<210> 198
<211> 456
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="IL7"

<400> 198
gattgtgata ttgaaggtaa agatggcaaa caatatgaga gtgttctaat ggtcagcatc       60

gatcaattat tggacagcat gaaagaaatt ggtagcaatt gcctgaataa tgaatttaac      120

ttttttaaaa gacatatctg tgatgctaat aaggaaggta tgtttttatt ccgtgctgct      180

cgcaagttga ggcaatttct taaaatgaat agcactggtg attttgatct ccacttatta      240

aaagtttcag aaggcacaac aatactgttg aactgcactg gccaggttaa aggaagaaaa      300

ccagctgccc tgggtgaagc ccaaccaaca aagagtttgg aagaaaataa atctttaaag      360

gaacagaaaa aactgaatga cttgtgtttc ctaaagagac tattacaaga gataaaaact      420

tgttggaata aaattttgat gggcactaaa gaacac                                456


<210> 199
<211> 466
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 199
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn 
    130                 135                 140                 


Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro 
145                 150                 155                 160 


Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly 
                165                 170                 175     


Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu 
            180                 185                 190         


Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val 
        195                 200                 205             


Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu 
    210                 215                 220                 


Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn 
225                 230                 235                 240 


Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val 
                245                 250                 255     


Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr 
            260                 265                 270         


Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu 
        275                 280                 285             


Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn 
    290                 295                 300                 


Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe 
305                 310                 315                 320 


Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr 
                325                 330                 335     


Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
            340                 345                 350         


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
        355                 360                 365             


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
    370                 375                 380                 


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
385                 390                 395                 400 


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
                405                 410                 415     


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
            420                 425                 430         


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
        435                 440                 445             


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
    450                 455                 460                 


Thr Ser 
465     


<210> 200
<211> 1398
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 200
caaggtcaag atcgccacat gattagaatg cgtcaactta tagatattgt tgatcagctg       60

aaaaattatg tgaatgactt ggtccctgaa tttctgccag ctccagaaga tgtagagaca      120

aactgtgagt ggtcagcttt ttcctgtttt cagaaggccc aactaaagtc agcaaataca      180

ggaaacaatg aaaggataat caatgtatca attaaaaagc tgaagaggaa accaccttcc      240

acaaatgcag ggagaagaca gaaacacaga ctaacatgcc cttcatgtga ttcttatgag      300

aaaaaaccac ccaaagaatt cctagaaaga ttcaaatcac ttctccaaaa gatgattcat      360

cagcatctgt cctctagaac acacggaagt gaagattcct caggcactac aaatactgtg      420

gcagcatata atttaacttg gaaatcaact aatttcaaga caattttgga gtgggaaccc      480

aaacccgtca atcaagtcta cactgttcaa ataagcacta agtcaggaga ttggaaaagc      540

aaatgctttt acacaacaga cacagagtgt gacctcaccg acgagattgt gaaggatgtg      600

aagcagacgt acttggcacg ggtcttctcc tacccggcag ggaatgtgga gagcaccggt      660

tctgctgggg agcctctgta tgagaactcc ccagagttca caccttacct ggagacaaac      720

ctcggacagc caacaattca gagttttgaa caggtgggaa caaaagtgaa tgtgaccgta      780

gaagatgaac ggactttagt cagaaggaac aacactttcc taagcctccg ggatgttttt      840

ggcaaggact taatttatac actttattat tggaaatctt caagttcagg aaagaaaaca      900

gccaaaacaa acactaatga gtttttgatt gatgtggata aaggagaaaa ctactgtttc      960

agtgttcaag cagtgattcc ctcccgaaca gttaaccgga agagtacaga cagcccggta     1020

gagtgtatgg gccaggagaa aggggaattc agagaaaact gggtgaacgt catcagcgat     1080

ttaaagaaga tcgaagattt aattcagtcc atgcatatcg acgccacttt atacacagaa     1140

tccgacgtgc acccctcttg taaggtgacc gccatgaaat gttttttact ggagctgcaa     1200

gttatctctt tagagagcgg agacgctagc atccacgaca ccgtggagaa tttaatcatt     1260

ttagccaata actctttatc cagcaacggc aacgtgacag agtccggctg caaggagtgc     1320

gaagagctgg aggagaagaa catcaaggag tttctgcaat cctttgtgca cattgtccag     1380

atgttcatca atacctcc                                                   1398


<210> 201
<211> 483
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 201
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp 
            20                  25                  30          


Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe 
        35                  40                  45              


Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe 
    50                  55                  60                  


Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn 
65                  70                  75                  80  


Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro 
                85                  90                  95      


Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser 
            100                 105                 110         


Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 
        115                 120                 125             


Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr 
    130                 135                 140                 


His Gly Ser Glu Asp Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr 
145                 150                 155                 160 


Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu 
                165                 170                 175     


Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser 
            180                 185                 190         


Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp 
        195                 200                 205             


Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg 
    210                 215                 220                 


Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly 
225                 230                 235                 240 


Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr 
                245                 250                 255     


Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys 
            260                 265                 270         


Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn 
        275                 280                 285             


Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr 
    290                 295                 300                 


Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr 
305                 310                 315                 320 


Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys 
                325                 330                 335     


Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser 
            340                 345                 350         


Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg 
        355                 360                 365             


Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
    370                 375                 380                 


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
385                 390                 395                 400 


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
                405                 410                 415     


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
            420                 425                 430         


Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
        435                 440                 445             


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
    450                 455                 460                 


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
465                 470                 475                 480 


Asn Thr Ser 
            


<210> 202
<211> 1449
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 202
atgggagtga aagttctttt tgcccttatt tgtattgctg tggccgaggc ccaaggtcaa       60

gatcgccaca tgattagaat gcgtcaactt atagatattg ttgatcagct gaaaaattat      120

gtgaatgact tggtccctga atttctgcca gctccagaag atgtagagac aaactgtgag      180

tggtcagctt tttcctgttt tcagaaggcc caactaaagt cagcaaatac aggaaacaat      240

gaaaggataa tcaatgtatc aattaaaaag ctgaagagga aaccaccttc cacaaatgca      300

gggagaagac agaaacacag actaacatgc ccttcatgtg attcttatga gaaaaaacca      360

cccaaagaat tcctagaaag attcaaatca cttctccaaa agatgattca tcagcatctg      420

tcctctagaa cacacggaag tgaagattcc tcaggcacta caaatactgt ggcagcatat      480

aatttaactt ggaaatcaac taatttcaag acaattttgg agtgggaacc caaacccgtc      540

aatcaagtct acactgttca aataagcact aagtcaggag attggaaaag caaatgcttt      600

tacacaacag acacagagtg tgacctcacc gacgagattg tgaaggatgt gaagcagacg      660

tacttggcac gggtcttctc ctacccggca gggaatgtgg agagcaccgg ttctgctggg      720

gagcctctgt atgagaactc cccagagttc acaccttacc tggagacaaa cctcggacag      780

ccaacaattc agagttttga acaggtggga acaaaagtga atgtgaccgt agaagatgaa      840

cggactttag tcagaaggaa caacactttc ctaagcctcc gggatgtttt tggcaaggac      900

ttaatttata cactttatta ttggaaatct tcaagttcag gaaagaaaac agccaaaaca      960

aacactaatg agtttttgat tgatgtggat aaaggagaaa actactgttt cagtgttcaa     1020

gcagtgattc cctcccgaac agttaaccgg aagagtacag acagcccggt agagtgtatg     1080

ggccaggaga aaggggaatt cagagaaaac tgggtgaacg tcatcagcga tttaaagaag     1140

atcgaagatt taattcagtc catgcatatc gacgccactt tatacacaga atccgacgtg     1200

cacccctctt gtaaggtgac cgccatgaaa tgttttttac tggagctgca agttatctct     1260

ttagagagcg gagacgctag catccacgac accgtggaga atttaatcat tttagccaat     1320

aactctttat ccagcaacgg caacgtgaca gagtccggct gcaaggagtg cgaagagctg     1380

gaggagaaga acatcaagga gtttctgcaa tcctttgtgc acattgtcca gatgttcatc     1440

aatacctcc                                                             1449


<210> 203
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 203
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Ile Thr Cys Pro Pro Pro Met Ser 
145                 150                 155                 160 


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
                165                 170                 175     


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
            180                 185                 190         


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
        195                 200                 205             


Thr Thr Pro Ser Leu Lys Cys Ile Arg 
    210                 215         


<210> 204
<211> 651
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 204
gattgtgata ttgaaggtaa agatggcaaa caatatgaga gtgttctaat ggtcagcatc       60

gatcaattat tggacagcat gaaagaaatt ggtagcaatt gcctgaataa tgaatttaac      120

ttttttaaaa gacatatctg tgatgctaat aaggaaggta tgtttttatt ccgtgctgct      180

cgcaagttga ggcaatttct taaaatgaat agcactggtg attttgatct ccacttatta      240

aaagtttcag aaggcacaac aatactgttg aactgcactg gccaggttaa aggaagaaaa      300

ccagctgccc tgggtgaagc ccaaccaaca aagagtttgg aagaaaataa atctttaaag      360

gaacagaaaa aactgaatga cttgtgtttc ctaaagagac tattacaaga gataaaaact      420

tgttggaata aaattttgat gggcactaaa gaacacatca cgtgccctcc ccccatgtcc      480

gtggaacacg cagacatctg ggtcaagagc tacagcttgt actccaggga gcggtacatt      540

tgtaactctg gtttcaagcg taaagccggc acgtccagcc tgacggagtg cgtgttgaac      600

aaggccacga atgtcgccca ctggacaacc cccagtctca aatgcattag a               651


<210> 205
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 205
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val 
            20                  25                  30          


Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly 
        35                  40                  45              


Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys 
    50                  55                  60                  


Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu 
65                  70                  75                  80  


Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu 
                85                  90                  95      


Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln 
            100                 105                 110         


Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys 
        115                 120                 125             


Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp 
    130                 135                 140                 


Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn 
145                 150                 155                 160 


Lys Ile Leu Met Gly Thr Lys Glu His Ile Thr Cys Pro Pro Pro Met 
                165                 170                 175     


Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser 
            180                 185                 190         


Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr 
        195                 200                 205             


Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His 
    210                 215                 220                 


Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 


<210> 206
<211> 702
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 206
atgggagtga aagttctttt tgcccttatt tgtattgctg tggccgaggc cgattgtgat       60

attgaaggta aagatggcaa acaatatgag agtgttctaa tggtcagcat cgatcaatta      120

ttggacagca tgaaagaaat tggtagcaat tgcctgaata atgaatttaa cttttttaaa      180

agacatatct gtgatgctaa taaggaaggt atgtttttat tccgtgctgc tcgcaagttg      240

aggcaatttc ttaaaatgaa tagcactggt gattttgatc tccacttatt aaaagtttca      300

gaaggcacaa caatactgtt gaactgcact ggccaggtta aaggaagaaa accagctgcc      360

ctgggtgaag cccaaccaac aaagagtttg gaagaaaata aatctttaaa ggaacagaaa      420

aaactgaatg acttgtgttt cctaaagaga ctattacaag agataaaaac ttgttggaat      480

aaaattttga tgggcactaa agaacacatc acgtgccctc cccccatgtc cgtggaacac      540

gcagacatct gggtcaagag ctacagcttg tactccaggg agcggtacat ttgtaactct      600

ggtttcaagc gtaaagccgg cacgtccagc ctgacggagt gcgtgttgaa caaggccacg      660

aatgtcgccc actggacaac ccccagtctc aaatgcatta ga                         702


<210> 207
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 207
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr Val Ala 
145                 150                 155                 160 


Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu 
                165                 170                 175     


Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr 
            180                 185                 190         


Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu 
        195                 200                 205             


Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu 
    210                 215                 220                 


Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser 
225                 230                 235                 240 


Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu 
                245                 250                 255     


Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly 
            260                 265                 270         


Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg 
        275                 280                 285             


Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile 
    290                 295                 300                 


Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala 
305                 310                 315                 320 


Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn 
                325                 330                 335     


Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg 
            340                 345                 350         


Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu 
        355                 360                 365             


Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
    370                 375                 380                 


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
385                 390                 395                 400 


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
                405                 410                 415     


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
            420                 425                 430         


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
        435                 440                 445             


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
    450                 455                 460                 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
465                 470                 475                 480 


Phe Ile Asn Thr Ser 
                485 


<210> 208
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 208
gattgcgaca tcgagggcaa ggacggcaag cagtacgaga gcgtgctgat ggtgtccatc       60

gaccagctgc tggacagcat gaaggagatc ggctccaact gcctcaacaa cgagttcaac      120

ttcttcaagc ggcacatctg cgacgccaac aaggagggca tgttcctgtt cagggccgcc      180

aggaaactgc ggcagttcct gaagatgaac tccaccggcg acttcgacct gcacctgctg      240

aaggtgtccg agggcaccac catcctgctg aactgcaccg gacaggtgaa gggccggaaa      300

cctgctgctc tgggagaggc ccaacccacc aagagcctgg aggagaacaa gtccctgaag      360

gagcagaaga agctgaacga cctgtgcttc ctgaagaggc tgctgcagga gatcaagacc      420

tgctggaaca agatcctgat gggcaccaag gagcatagcg gcacaaccaa cacagtcgct      480

gcctataacc tcacttggaa gagcaccaac ttcaaaacca tcctcgaatg ggaacccaaa      540

cccgttaacc aagtttacac cgtgcagatc agcaccaagt ccggcgactg gaagtccaaa      600

tgtttctata ccaccgacac cgagtgcgat ctcaccgatg agatcgtgaa agatgtgaaa      660

cagacctacc tcgcccgggt gtttagctac cccgccggca atgtggagag cactggttcc      720

gctggcgagc ctttatacga gaacagcccc gaatttaccc cttacctcga gaccaattta      780

ggacagccca ccatccaaag ctttgagcaa gttggcacaa aggtgaatgt gacagtggag      840

gacgagcgga ctttagtgcg gcggaacaac acctttctca gcctccggga tgtgttcggc      900

aaagatttaa tctacacact gtattactgg aagtcctctt cctccggcaa gaagacagct      960

aaaaccaaca caaacgagtt tttaatcgac gtggataaag gcgaaaacta ctgtttcagc     1020

gtgcaagctg tgatcccctc ccggaccgtg aataggaaaa gcaccgatag ccccgttgag     1080

tgcatgggcc aagaaaaggg cgagttccgg gagaactggg tgaacgtcat cagcgattta     1140

aagaagatcg aagatttaat tcagtccatg catatcgacg ccactttata cacagaatcc     1200

gacgtgcacc cctcttgtaa ggtgaccgcc atgaaatgtt ttttactgga gctgcaagtt     1260

atctctttag agagcggaga cgctagcatc cacgacaccg tggagaattt aatcatttta     1320

gccaataact ctttatccag caacggcaac gtgacagagt ccggctgcaa ggagtgcgaa     1380

gagctggagg agaagaacat caaggagttt ctgcaatcct ttgtgcacat tgtccagatg     1440

ttcatcaata cctcc                                                      1455


<210> 209
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 209
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
            20                  25                  30          


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
        35                  40                  45              


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
    50                  55                  60                  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
65                  70                  75                  80  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
                85                  90                  95      


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
            100                 105                 110         


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
        115                 120                 125             


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
    130                 135                 140                 


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
145                 150                 155                 160 


Asn Lys Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr 
                165                 170                 175     


Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile 
            180                 185                 190         


Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile 
        195                 200                 205             


Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp 
    210                 215                 220                 


Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr 
225                 230                 235                 240 


Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr 
                245                 250                 255     


Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro 
            260                 265                 270         


Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln 
        275                 280                 285             


Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val 
    290                 295                 300                 


Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp 
305                 310                 315                 320 


Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys 
                325                 330                 335     


Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly 
            340                 345                 350         


Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val 
        355                 360                 365             


Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys 
    370                 375                 380                 


Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
385                 390                 395                 400 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                405                 410                 415     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            420                 425                 430         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        435                 440                 445             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    450                 455                 460                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
465                 470                 475                 480 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                485                 490                 495     


Gln Met Phe Ile Asn Thr Ser 
            500             


<210> 210
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 210
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccgattgc       60

gacatcgagg gcaaggacgg caagcagtac gagagcgtgc tgatggtgtc catcgaccag      120

ctgctggaca gcatgaagga gatcggctcc aactgcctca acaacgagtt caacttcttc      180

aagcggcaca tctgcgacgc caacaaggag ggcatgttcc tgttcagggc cgccaggaaa      240

ctgcggcagt tcctgaagat gaactccacc ggcgacttcg acctgcacct gctgaaggtg      300

tccgagggca ccaccatcct gctgaactgc accggacagg tgaagggccg gaaacctgct      360

gctctgggag aggcccaacc caccaagagc ctggaggaga acaagtccct gaaggagcag      420

aagaagctga acgacctgtg cttcctgaag aggctgctgc aggagatcaa gacctgctgg      480

aacaagatcc tgatgggcac caaggagcat agcggcacaa ccaacacagt cgctgcctat      540

aacctcactt ggaagagcac caacttcaaa accatcctcg aatgggaacc caaacccgtt      600

aaccaagttt acaccgtgca gatcagcacc aagtccggcg actggaagtc caaatgtttc      660

tataccaccg acaccgagtg cgatctcacc gatgagatcg tgaaagatgt gaaacagacc      720

tacctcgccc gggtgtttag ctaccccgcc ggcaatgtgg agagcactgg ttccgctggc      780

gagcctttat acgagaacag ccccgaattt accccttacc tcgagaccaa tttaggacag      840

cccaccatcc aaagctttga gcaagttggc acaaaggtga atgtgacagt ggaggacgag      900

cggactttag tgcggcggaa caacaccttt ctcagcctcc gggatgtgtt cggcaaagat      960

ttaatctaca cactgtatta ctggaagtcc tcttcctccg gcaagaagac agctaaaacc     1020

aacacaaacg agtttttaat cgacgtggat aaaggcgaaa actactgttt cagcgtgcaa     1080

gctgtgatcc cctcccggac cgtgaatagg aaaagcaccg atagccccgt tgagtgcatg     1140

ggccaagaaa agggcgagtt ccgggagaac tgggtgaacg tcatcagcga tttaaagaag     1200

atcgaagatt taattcagtc catgcatatc gacgccactt tatacacaga atccgacgtg     1260

cacccctctt gtaaggtgac cgccatgaaa tgttttttac tggagctgca agttatctct     1320

ttagagagcg gagacgctag catccacgac accgtggaga atttaatcat tttagccaat     1380

aactctttat ccagcaacgg caacgtgaca gagtccggct gcaaggagtg cgaagagctg     1440

gaggagaaga acatcaagga gtttctgcaa tcctttgtgc acattgtcca gatgttcatc     1500

aatacctcc                                                             1509


<210> 211
<211> 198
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 211
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
    130                 135                 140                 


Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
145                 150                 155                 160 


Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
                165                 170                 175     


Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
            180                 185                 190         


Ser Leu Lys Cys Ile Arg 
        195             


<210> 212
<211> 594
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 212
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcca ttacatgccc ccctcccatg      420

agcgtggagc acgccgacat ctgggtgaag agctatagcc tctacagccg ggagaggtat      480

atctgtaaca gcggcttcaa gaggaaggcc ggcaccagca gcctcaccga gtgcgtgctg      540

aataaggcta ccaacgtggc tcactggaca acaccctctt taaagtgcat ccgg            594


<210> 213
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 213
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg 
    210                 215     


<210> 214
<211> 648
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 214
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tccattacat gcccccctcc catgagcgtg      480

gagcacgccg acatctgggt gaagagctat agcctctaca gccgggagag gtatatctgt      540

aacagcggct tcaagaggaa ggccggcacc agcagcctca ccgagtgcgt gctgaataag      600

gctaccaacg tggctcactg gacaacaccc tctttaaagt gcatccgg                   648


<210> 215
<211> 108
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD16"

<400> 215
Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His 
            100                 105             


<210> 216
<211> 324
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD16"

<400> 216
tccgagctga cccaggaccc tgctgtgtcc gtggctctgg gccagaccgt gaggatcacc       60

tgccagggcg actccctgag gtcctactac gcctcctggt accagcagaa gcccggccag      120

gctcctgtgc tggtgatcta cggcaagaac aacaggccct ccggcatccc tgacaggttc      180

tccggatcct cctccggcaa caccgcctcc ctgaccatca caggcgctca ggccgaggac      240

gaggctgact actactgcaa ctccagggac tcctccggca accatgtggt gttcggcggc      300

ggcaccaagc tgaccgtggg ccat                                             324


<210> 217
<211> 117
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD16"

<400> 217
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Arg 
        115         


<210> 218
<211> 351
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD16"

<400> 218
gaggtgcagc tggtggagtc cggaggagga gtggtgaggc ctggaggctc cctgaggctg       60

agctgtgctg cctccggctt caccttcgac gactacggca tgtcctgggt gaggcaggct      120

cctggaaagg gcctggagtg ggtgtccggc atcaactgga acggcggatc caccggctac      180

gccgattccg tgaagggcag gttcaccatc agcagggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgag ggccgaggac accgccgtgt actactgcgc caggggcagg      300

tccctgctgt tcgactactg gggacagggc accctggtga ccgtgtccag g               351


<210> 219

<400> 219
000


<210> 220

<400> 220
000


<210> 221

<400> 221
000


<210> 222

<400> 222
000


<210> 223
<211> 823
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 223
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
        515                 520                 525             


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
    530                 535                 540                 


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
545                 550                 555                 560 


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                565                 570                 575     


Pro Ser Leu Lys Cys Ile Arg Ser Glu Leu Thr Gln Asp Pro Ala Val 
            580                 585                 590         


Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser 
        595                 600                 605             


Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    610                 615                 620                 


Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro 
625                 630                 635                 640 


Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile 
                645                 650                 655     


Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg 
            660                 665                 670         


Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
        675                 680                 685             


Val Gly His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    690                 695                 700                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro 
705                 710                 715                 720 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
                725                 730                 735     


Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            740                 745                 750         


Trp Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp 
        755                 760                 765             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
    770                 775                 780                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
785                 790                 795                 800 


Tyr Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly 
                805                 810                 815     


Thr Leu Val Thr Val Ser Arg 
            820             


<210> 224
<211> 2469
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 224
atttgggaac tgaagaagga cgtctacgtg gtcgaactgg actggtatcc cgatgctccc       60

ggcgaaatgg tggtgctcac ttgtgacacc cccgaagaag acggcatcac ttggaccctc      120

gatcagagca gcgaggtgct gggctccgga aagaccctca caatccaagt taaggagttc      180

ggagacgctg gccaatacac atgccacaag ggaggcgagg tgctcagcca ttccttatta      240

ttattacaca agaaggaaga cggaatctgg tccaccgaca ttttaaaaga tcagaaggag      300

cccaagaata agaccttttt aaggtgtgag gccaaaaact acagcggtcg tttcacttgt      360

tggtggctga ccaccatttc caccgattta accttctccg tgaaaagcag ccggggaagc      420

tccgaccctc aaggtgtgac atgtggagcc gctaccctca gcgctgagag ggttcgtggc      480

gataacaagg aatacgagta cagcgtggag tgccaagaag atagcgcttg tcccgctgcc      540

gaagaatctt tacccattga ggtgatggtg gacgccgtgc acaaactcaa gtacgagaac      600

tacacctcct ccttctttat ccgggacatc attaagcccg atcctcctaa gaatttacag      660

ctgaagcctc tcaaaaatag ccggcaagtt gaggtctctt gggaatatcc cgacacttgg      720

agcacacccc acagctactt ctctttaacc ttttgtgtgc aagttcaagg taaaagcaag      780

cgggagaaga aagaccgggt gtttaccgac aaaaccagcg ccaccgtcat ctgtcggaag      840

aacgcctcca tcagcgtgag ggctcaagat cgttattact ccagcagctg gtccgagtgg      900

gccagcgtgc cttgttccgg cggtggagga tccggaggag gtggctccgg cggcggagga      960

tctcgtaacc tccccgtggc tacccccgat cccggaatgt tcccttgttt acaccacagc     1020

cagaatttac tgagggccgt gagcaacatg ctgcagaaag ctaggcagac tttagaattt     1080

tacccttgca ccagcgagga gatcgaccat gaagatatca ccaaggacaa gacatccacc     1140

gtggaggctt gtttacctct ggagctgaca aagaacgagt cttgtctcaa ctctcgtgaa     1200

accagcttca tcacaaatgg ctcttgttta gcttcccgga agacctcctt tatgatggct     1260

ttatgcctca gctccatcta cgaggattta aagatgtacc aagtggagtt caagaccatg     1320

aacgccaagc tgctcatgga ccctaaacgg cagatctttt tagaccagaa catgctggct     1380

gtgattgatg agctgatgca agctttaaac ttcaactccg agaccgtccc tcagaagtcc     1440

tccctcgagg agcccgattt ttacaagaca aagatcaaac tgtgcatttt actccacgcc     1500

tttaggatcc gggccgtgac cattgaccgg gtcatgagct atttaaacgc cagcattaca     1560

tgcccccctc ccatgagcgt ggagcacgcc gacatctggg tgaagagcta tagcctctac     1620

agccgggaga ggtatatctg taacagcggc ttcaagagga aggccggcac cagcagcctc     1680

accgagtgcg tgctgaataa ggctaccaac gtggctcact ggacaacacc ctctttaaag     1740

tgcatccggt ccgagctgac ccaggaccct gctgtgtccg tggctctggg ccagaccgtg     1800

aggatcacct gccagggcga ctccctgagg tcctactacg cctcctggta ccagcagaag     1860

cccggccagg ctcctgtgct ggtgatctac ggcaagaaca acaggccctc cggcatccct     1920

gacaggttct ccggatcctc ctccggcaac accgcctccc tgaccatcac aggcgctcag     1980

gccgaggacg aggctgacta ctactgcaac tccagggact cctccggcaa ccatgtggtg     2040

ttcggcggcg gcaccaagct gaccgtgggc catggcggcg gcggctccgg aggcggcggc     2100

agcggcggag gaggatccga ggtgcagctg gtggagtccg gaggaggagt ggtgaggcct     2160

ggaggctccc tgaggctgag ctgtgctgcc tccggcttca ccttcgacga ctacggcatg     2220

tcctgggtga ggcaggctcc tggaaagggc ctggagtggg tgtccggcat caactggaac     2280

ggcggatcca ccggctacgc cgattccgtg aagggcaggt tcaccatcag cagggacaac     2340

gccaagaact ccctgtacct gcagatgaac tccctgaggg ccgaggacac cgccgtgtac     2400

tactgcgcca ggggcaggtc cctgctgttc gactactggg gacagggcac cctggtgacc     2460

gtgtccagg                                                             2469


<210> 225
<211> 841
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 225
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp 
            20                  25                  30          


Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr 
        35                  40                  45              


Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val 
    50                  55                  60                  


Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp 
65                  70                  75                  80  


Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser 
                85                  90                  95      


Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile 
            100                 105                 110         


Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu 
        115                 120                 125             


Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile 
    130                 135                 140                 


Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp 
145                 150                 155                 160 


Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val 
                165                 170                 175     


Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp 
            180                 185                 190         


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val 
        195                 200                 205             


Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
    210                 215                 220                 


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
            260                 265                 270         


Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp 
        275                 280                 285             


Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val 
    290                 295                 300                 


Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
305                 310                 315                 320 


Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            340                 345                 350         


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        355                 360                 365             


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    370                 375                 380                 


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
385                 390                 395                 400 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                405                 410                 415     


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            420                 425                 430         


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
        435                 440                 445             


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    450                 455                 460                 


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
465                 470                 475                 480 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                485                 490                 495     


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            500                 505                 510         


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        515                 520                 525             


Val Met Ser Tyr Leu Asn Ala Ser Ile Thr Cys Pro Pro Pro Met Ser 
    530                 535                 540                 


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
545                 550                 555                 560 


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
                565                 570                 575     


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
            580                 585                 590         


Thr Thr Pro Ser Leu Lys Cys Ile Arg Ser Glu Leu Thr Gln Asp Pro 
        595                 600                 605             


Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly 
    610                 615                 620                 


Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
625                 630                 635                 640 


Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly 
                645                 650                 655     


Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu 
            660                 665                 670         


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn 
        675                 680                 685             


Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys 
    690                 695                 700                 


Leu Thr Val Gly His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
705                 710                 715                 720 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                725                 730                 735     


Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            740                 745                 750         


Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
        755                 760                 765             


Leu Glu Trp Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr 
    770                 775                 780                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
785                 790                 795                 800 


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                805                 810                 815     


Val Tyr Tyr Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly 
            820                 825                 830         


Gln Gly Thr Leu Val Thr Val Ser Arg 
        835                 840     


<210> 226
<211> 2523
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 226
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctccatttgg       60

gaactgaaga aggacgtcta cgtggtcgaa ctggactggt atcccgatgc tcccggcgaa      120

atggtggtgc tcacttgtga cacccccgaa gaagacggca tcacttggac cctcgatcag      180

agcagcgagg tgctgggctc cggaaagacc ctcacaatcc aagttaagga gttcggagac      240

gctggccaat acacatgcca caagggaggc gaggtgctca gccattcctt attattatta      300

cacaagaagg aagacggaat ctggtccacc gacattttaa aagatcagaa ggagcccaag      360

aataagacct ttttaaggtg tgaggccaaa aactacagcg gtcgtttcac ttgttggtgg      420

ctgaccacca tttccaccga tttaaccttc tccgtgaaaa gcagccgggg aagctccgac      480

cctcaaggtg tgacatgtgg agccgctacc ctcagcgctg agagggttcg tggcgataac      540

aaggaatacg agtacagcgt ggagtgccaa gaagatagcg cttgtcccgc tgccgaagaa      600

tctttaccca ttgaggtgat ggtggacgcc gtgcacaaac tcaagtacga gaactacacc      660

tcctccttct ttatccggga catcattaag cccgatcctc ctaagaattt acagctgaag      720

cctctcaaaa atagccggca agttgaggtc tcttgggaat atcccgacac ttggagcaca      780

ccccacagct acttctcttt aaccttttgt gtgcaagttc aaggtaaaag caagcgggag      840

aagaaagacc gggtgtttac cgacaaaacc agcgccaccg tcatctgtcg gaagaacgcc      900

tccatcagcg tgagggctca agatcgttat tactccagca gctggtccga gtgggccagc      960

gtgccttgtt ccggcggtgg aggatccgga ggaggtggct ccggcggcgg aggatctcgt     1020

aacctccccg tggctacccc cgatcccgga atgttccctt gtttacacca cagccagaat     1080

ttactgaggg ccgtgagcaa catgctgcag aaagctaggc agactttaga attttaccct     1140

tgcaccagcg aggagatcga ccatgaagat atcaccaagg acaagacatc caccgtggag     1200

gcttgtttac ctctggagct gacaaagaac gagtcttgtc tcaactctcg tgaaaccagc     1260

ttcatcacaa atggctcttg tttagcttcc cggaagacct cctttatgat ggctttatgc     1320

ctcagctcca tctacgagga tttaaagatg taccaagtgg agttcaagac catgaacgcc     1380

aagctgctca tggaccctaa acggcagatc tttttagacc agaacatgct ggctgtgatt     1440

gatgagctga tgcaagcttt aaacttcaac tccgagaccg tccctcagaa gtcctccctc     1500

gaggagcccg atttttacaa gacaaagatc aaactgtgca ttttactcca cgcctttagg     1560

atccgggccg tgaccattga ccgggtcatg agctatttaa acgccagcat tacatgcccc     1620

cctcccatga gcgtggagca cgccgacatc tgggtgaaga gctatagcct ctacagccgg     1680

gagaggtata tctgtaacag cggcttcaag aggaaggccg gcaccagcag cctcaccgag     1740

tgcgtgctga ataaggctac caacgtggct cactggacaa caccctcttt aaagtgcatc     1800

cggtccgagc tgacccagga ccctgctgtg tccgtggctc tgggccagac cgtgaggatc     1860

acctgccagg gcgactccct gaggtcctac tacgcctcct ggtaccagca gaagcccggc     1920

caggctcctg tgctggtgat ctacggcaag aacaacaggc cctccggcat ccctgacagg     1980

ttctccggat cctcctccgg caacaccgcc tccctgacca tcacaggcgc tcaggccgag     2040

gacgaggctg actactactg caactccagg gactcctccg gcaaccatgt ggtgttcggc     2100

ggcggcacca agctgaccgt gggccatggc ggcggcggct ccggaggcgg cggcagcggc     2160

ggaggaggat ccgaggtgca gctggtggag tccggaggag gagtggtgag gcctggaggc     2220

tccctgaggc tgagctgtgc tgcctccggc ttcaccttcg acgactacgg catgtcctgg     2280

gtgaggcagg ctcctggaaa gggcctggag tgggtgtccg gcatcaactg gaacggcgga     2340

tccaccggct acgccgattc cgtgaagggc aggttcacca tcagcaggga caacgccaag     2400

aactccctgt acctgcagat gaactccctg agggccgagg acaccgccgt gtactactgc     2460

gccaggggca ggtccctgct gttcgactac tggggacagg gcaccctggt gaccgtgtcc     2520

agg                                                                   2523


<210> 227
<211> 456
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL7"

<400> 227
gattgcgaca tcgagggcaa ggacggcaag cagtacgaga gcgtgctgat ggtgtccatc       60

gaccagctgc tggacagcat gaaggagatc ggctccaact gcctcaacaa cgagttcaac      120

ttcttcaagc ggcacatctg cgacgccaac aaggagggca tgttcctgtt cagggccgcc      180

aggaaactgc ggcagttcct gaagatgaac tccaccggcg acttcgacct gcacctgctg      240

aaggtgtccg agggcaccac catcctgctg aactgcaccg gacaggtgaa gggccggaaa      300

cctgctgctc tgggagaggc ccaacccacc aagagcctgg aggagaacaa gtccctgaag      360

gagcagaaga agctgaacga cctgtgcttc ctgaagaggc tgctgcagga gatcaagacc      420

tgctggaaca agatcctgat gggcaccaag gagcat                                456


<210> 228

<400> 228
000


<210> 229

<400> 229
000


<210> 230

<400> 230
000


<210> 231

<400> 231
000


<210> 232
<211> 438
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 232
Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp 
                165                 170                 175     


Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ser 
    210                 215                 220                 


Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg 
225                 230                 235                 240 


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
                245                 250                 255     


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            260                 265                 270         


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        275                 280                 285             


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    290                 295                 300                 


Arg Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp 
305                 310                 315                 320 


Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe 
                325                 330                 335     


Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe 
            340                 345                 350         


Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn 
        355                 360                 365             


Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro 
    370                 375                 380                 


Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser 
385                 390                 395                 400 


Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 
                405                 410                 415     


Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr 
            420                 425                 430         


His Gly Ser Glu Asp Ser 
        435             


<210> 233
<211> 1314
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 233
tccgagctga cccaggaccc tgctgtgtcc gtggctctgg gccagaccgt gaggatcacc       60

tgccagggcg actccctgag gtcctactac gcctcctggt accagcagaa gcccggccag      120

gctcctgtgc tggtgatcta cggcaagaac aacaggccct ccggcatccc tgacaggttc      180

tccggatcct cctccggcaa caccgcctcc ctgaccatca caggcgctca ggccgaggac      240

gaggctgact actactgcaa ctccagggac tcctccggca accatgtggt gttcggcggc      300

ggcaccaagc tgaccgtggg ccatggcggc ggcggctccg gaggcggcgg cagcggcgga      360

ggaggatccg aggtgcagct ggtggagtcc ggaggaggag tggtgaggcc tggaggctcc      420

ctgaggctga gctgtgctgc ctccggcttc accttcgacg actacggcat gtcctgggtg      480

aggcaggctc ctggaaaggg cctggagtgg gtgtccggca tcaactggaa cggcggatcc      540

accggctacg ccgattccgt gaagggcagg ttcaccatca gcagggacaa cgccaagaac      600

tccctgtacc tgcagatgaa ctccctgagg gccgaggaca ccgccgtgta ctactgcgcc      660

aggggcaggt ccctgctgtt cgactactgg ggacagggca ccctggtgac cgtgtccagg      720

attacatgcc cccctcccat gagcgtggag cacgccgaca tctgggtgaa gagctatagc      780

ctctacagcc gggagaggta tatctgtaac agcggcttca agaggaaggc cggcaccagc      840

agcctcaccg agtgcgtgct gaataaggct accaacgtgg ctcactggac aacaccctct      900

ttaaagtgca tccggcaggg ccaggacagg cacatgatcc ggatgaggca gctcatcgac      960

atcgtcgacc agctgaagaa ctacgtgaac gacctggtgc ccgagtttct gcctgccccc     1020

gaggacgtgg agaccaactg cgagtggtcc gccttctcct gctttcagaa ggcccagctg     1080

aagtccgcca acaccggcaa caacgagcgg atcatcaacg tgagcatcaa gaagctgaag     1140

cggaagcctc cctccacaaa cgccggcagg aggcagaagc acaggctgac ctgccccagc     1200

tgtgactcct acgagaagaa gccccccaag gagttcctgg agaggttcaa gtccctgctg     1260

cagaagatga tccatcagca cctgtcctcc aggacccacg gctccgagga ctcc           1314


<210> 234
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 234
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
            20                  25                  30          


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 
        35                  40                  45              


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
    50                  55                  60                  


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
65                  70                  75                  80  


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
                85                  90                  95      


Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn 
            100                 105                 110         


His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser 
                165                 170                 175     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile 
            180                 185                 190         


Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
225                 230                 235                 240 


Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Arg Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
            260                 265                 270         


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
        275                 280                 285             


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
    290                 295                 300                 


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
305                 310                 315                 320 


Cys Ile Arg Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu 
                325                 330                 335     


Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro 
            340                 345                 350         


Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser 
        355                 360                 365             


Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly 
    370                 375                 380                 


Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys 
385                 390                 395                 400 


Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys 
                405                 410                 415     


Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu 
            420                 425                 430         


Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser 
        435                 440                 445             


Arg Thr His Gly Ser Glu Asp Ser 
    450                 455     


<210> 235
<211> 1368
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 235
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcctccgag       60

ctgacccagg accctgctgt gtccgtggct ctgggccaga ccgtgaggat cacctgccag      120

ggcgactccc tgaggtccta ctacgcctcc tggtaccagc agaagcccgg ccaggctcct      180

gtgctggtga tctacggcaa gaacaacagg ccctccggca tccctgacag gttctccgga      240

tcctcctccg gcaacaccgc ctccctgacc atcacaggcg ctcaggccga ggacgaggct      300

gactactact gcaactccag ggactcctcc ggcaaccatg tggtgttcgg cggcggcacc      360

aagctgaccg tgggccatgg cggcggcggc tccggaggcg gcggcagcgg cggaggagga      420

tccgaggtgc agctggtgga gtccggagga ggagtggtga ggcctggagg ctccctgagg      480

ctgagctgtg ctgcctccgg cttcaccttc gacgactacg gcatgtcctg ggtgaggcag      540

gctcctggaa agggcctgga gtgggtgtcc ggcatcaact ggaacggcgg atccaccggc      600

tacgccgatt ccgtgaaggg caggttcacc atcagcaggg acaacgccaa gaactccctg      660

tacctgcaga tgaactccct gagggccgag gacaccgccg tgtactactg cgccaggggc      720

aggtccctgc tgttcgacta ctggggacag ggcaccctgg tgaccgtgtc caggattaca      780

tgcccccctc ccatgagcgt ggagcacgcc gacatctggg tgaagagcta tagcctctac      840

agccgggaga ggtatatctg taacagcggc ttcaagagga aggccggcac cagcagcctc      900

accgagtgcg tgctgaataa ggctaccaac gtggctcact ggacaacacc ctctttaaag      960

tgcatccggc agggccagga caggcacatg atccggatga ggcagctcat cgacatcgtc     1020

gaccagctga agaactacgt gaacgacctg gtgcccgagt ttctgcctgc ccccgaggac     1080

gtggagacca actgcgagtg gtccgccttc tcctgctttc agaaggccca gctgaagtcc     1140

gccaacaccg gcaacaacga gcggatcatc aacgtgagca tcaagaagct gaagcggaag     1200

cctccctcca caaacgccgg caggaggcag aagcacaggc tgacctgccc cagctgtgac     1260

tcctacgaga agaagccccc caaggagttc ctggagaggt tcaagtccct gctgcagaag     1320

atgatccatc agcacctgtc ctccaggacc cacggctccg aggactcc                  1368


<210> 236
<211> 620
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 236
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser 
        275                 280                 285             


Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr 
    290                 295                 300                 


Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val 
305                 310                 315                 320 


Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys 
                325                 330                 335     


Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
            340                 345                 350         


Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly 
        355                 360                 365             


Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser 
    370                 375                 380                 


Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile 
385                 390                 395                 400 


Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp 
                405                 410                 415     


Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp 
            420                 425                 430         


Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser 
        435                 440                 445             


Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile 
    450                 455                 460                 


Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile 
465                 470                 475                 480 


Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys 
                485                 490                 495     


Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile 
            500                 505                 510         


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        515                 520                 525             


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    530                 535                 540                 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
545                 550                 555                 560 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                565                 570                 575     


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            580                 585                 590         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        595                 600                 605             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620 


<210> 237
<211> 1860
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 237
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cagcggcaca accaacacag tcgctgccta taacctcact      900

tggaagagca ccaacttcaa aaccatcctc gaatgggaac ccaaacccgt taaccaagtt      960

tacaccgtgc agatcagcac caagtccggc gactggaagt ccaaatgttt ctataccacc     1020

gacaccgagt gcgatctcac cgatgagatc gtgaaagatg tgaaacagac ctacctcgcc     1080

cgggtgttta gctaccccgc cggcaatgtg gagagcactg gttccgctgg cgagccttta     1140

tacgagaaca gccccgaatt taccccttac ctcgagacca atttaggaca gcccaccatc     1200

caaagctttg agcaagttgg cacaaaggtg aatgtgacag tggaggacga gcggacttta     1260

gtgcggcgga acaacacctt tctcagcctc cgggatgtgt tcggcaaaga tttaatctac     1320

acactgtatt actggaagtc ctcttcctcc ggcaagaaga cagctaaaac caacacaaac     1380

gagtttttaa tcgacgtgga taaaggcgaa aactactgtt tcagcgtgca agctgtgatc     1440

ccctcccgga ccgtgaatag gaaaagcacc gatagccccg ttgagtgcat gggccaagaa     1500

aagggcgagt tccgggagaa ctgggtgaac gtcatcagcg atttaaagaa gatcgaagat     1560

ttaattcagt ccatgcatat cgacgccact ttatacacag aatccgacgt gcacccctct     1620

tgtaaggtga ccgccatgaa atgtttttta ctggagctgc aagttatctc tttagagagc     1680

ggagacgcta gcatccacga caccgtggag aatttaatca ttttagccaa taactcttta     1740

tccagcaacg gcaacgtgac agagtccggc tgcaaggagt gcgaagagct ggaggagaag     1800

aacatcaagg agtttctgca atcctttgtg cacattgtcc agatgttcat caatacctcc     1860


<210> 238
<211> 638
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 238
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys 
305                 310                 315                 320 


Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn 
                325                 330                 335     


Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser 
            340                 345                 350         


Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile 
        355                 360                 365             


Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro 
    370                 375                 380                 


Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu 
385                 390                 395                 400 


Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro 
                405                 410                 415     


Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val 
            420                 425                 430         


Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu 
        435                 440                 445             


Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys 
    450                 455                 460                 


Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe 
465                 470                 475                 480 


Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala 
                485                 490                 495     


Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val 
            500                 505                 510         


Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn 
        515                 520                 525             


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
    530                 535                 540                 


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
545                 550                 555                 560 


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
                565                 570                 575     


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
            580                 585                 590         


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
        595                 600                 605             


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
    610                 615                 620                 


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
625                 630                 635             


<210> 239
<211> 1914
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 239
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacagcgg cacaaccaac acagtcgctg cctataacct cacttggaag      960

agcaccaact tcaaaaccat cctcgaatgg gaacccaaac ccgttaacca agtttacacc     1020

gtgcagatca gcaccaagtc cggcgactgg aagtccaaat gtttctatac caccgacacc     1080

gagtgcgatc tcaccgatga gatcgtgaaa gatgtgaaac agacctacct cgcccgggtg     1140

tttagctacc ccgccggcaa tgtggagagc actggttccg ctggcgagcc tttatacgag     1200

aacagccccg aatttacccc ttacctcgag accaatttag gacagcccac catccaaagc     1260

tttgagcaag ttggcacaaa ggtgaatgtg acagtggagg acgagcggac tttagtgcgg     1320

cggaacaaca cctttctcag cctccgggat gtgttcggca aagatttaat ctacacactg     1380

tattactgga agtcctcttc ctccggcaag aagacagcta aaaccaacac aaacgagttt     1440

ttaatcgacg tggataaagg cgaaaactac tgtttcagcg tgcaagctgt gatcccctcc     1500

cggaccgtga ataggaaaag caccgatagc cccgttgagt gcatgggcca agaaaagggc     1560

gagttccggg agaactgggt gaacgtcatc agcgatttaa agaagatcga agatttaatt     1620

cagtccatgc atatcgacgc cactttatac acagaatccg acgtgcaccc ctcttgtaag     1680

gtgaccgcca tgaaatgttt tttactggag ctgcaagtta tctctttaga gagcggagac     1740

gctagcatcc acgacaccgt ggagaattta atcattttag ccaataactc tttatccagc     1800

aacggcaacg tgacagagtc cggctgcaag gagtgcgaag agctggagga gaagaacatc     1860

aaggagtttc tgcaatcctt tgtgcacatt gtccagatgt tcatcaatac ctcc           1914


<210> 240

<400> 240
000


<210> 241

<400> 241
000


<210> 242

<400> 242
000


<210> 243

<400> 243
000


<210> 244

<400> 244
000


<210> 245

<400> 245
000


<210> 246

<400> 246
000


<210> 247

<400> 247
000


<210> 248

<400> 248
000


<210> 249

<400> 249
000


<210> 250
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-7s sequence"

<400> 250
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
            20                  25                  30          


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
        35                  40                  45              


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
    50                  55                  60                  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
65                  70                  75                  80  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
                85                  90                  95      


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
            100                 105                 110         


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
        115                 120                 125             


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
    130                 135                 140                 


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
145                 150                 155                 160 


Asn Lys Ile Leu Met Gly Thr Lys Glu His Ile Thr Cys Pro Pro Pro 
                165                 170                 175     


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
            180                 185                 190         


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
        195                 200                 205             


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
    210                 215                 220                 


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235 


<210> 251
<211> 705
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-7s sequence"

<400> 251
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccgattgc       60

gacatcgagg gcaaggacgg caagcagtac gagagcgtgc tgatggtgtc catcgaccag      120

ctgctggaca gcatgaagga gatcggctcc aactgcctca acaacgagtt caacttcttc      180

aagcggcaca tctgcgacgc caacaaggag ggcatgttcc tgttcagggc cgccaggaaa      240

ctgcggcagt tcctgaagat gaactccacc ggcgacttcg acctgcacct gctgaaggtg      300

tccgagggca ccaccatcct gctgaactgc accggacagg tgaagggccg gaaacctgct      360

gctctgggag aggcccaacc caccaagagc ctggaggaga acaagtccct gaaggagcag      420

aagaagctga acgacctgtg cttcctgaag aggctgctgc aggagatcaa gacctgctgg      480

aacaagatcc tgatgggcac caaggagcat attacatgcc cccctcccat gagcgtggag      540

cacgccgaca tctgggtgaa gagctatagc ctctacagcc gggagaggta tatctgtaac      600

agcggcttca agaggaaggc cggcaccagc agcctcaccg agtgcgtgct gaataaggct      660

accaacgtgg ctcactggac aacaccctct ttaaagtgca tccgg                      705


<210> 252

<400> 252
000


<210> 253

<400> 253
000


<210> 254

<400> 254
000


<210> 255

<400> 255
000


<210> 256

<400> 256
000


<210> 257
<211> 1056
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs sequence"

<400> 257
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cattacatgc ccccctccca tgagcgtgga gcacgccgac      900

atctgggtga agagctatag cctctacagc cgggagaggt atatctgtaa cagcggcttc      960

aagaggaagg ccggcaccag cagcctcacc gagtgcgtgc tgaataaggc taccaacgtg     1020

gctcactgga caacaccctc tttaaagtgc atccgg                               1056


<210> 258

<400> 258
000


<210> 259
<211> 1110
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs sequence"

<400> 259
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacattac atgcccccct cccatgagcg tggagcacgc cgacatctgg      960

gtgaagagct atagcctcta cagccgggag aggtatatct gtaacagcgg cttcaagagg     1020

aaggccggca ccagcagcct caccgagtgc gtgctgaata aggctaccaa cgtggctcac     1080

tggacaacac cctctttaaa gtgcatccgg                                      1110


<210> 260
<211> 184
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD137"

<400> 260
Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 


<210> 261
<211> 552
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD137"

<400> 261
cgcgagggtc ccgagctttc gcccgacgat cccgccggcc tcttggacct gcggcagggc       60

atgtttgcgc agctggtggc ccaaaatgtt ctgctgatcg atgggcccct gagctggtac      120

agtgacccag gcctggcagg cgtgtccctg acggggggcc tgagctacaa agaggacacg      180

aaggagctgg tggtggccaa ggctggagtc tactatgtct tctttcaact agagctgcgg      240

cgcgtggtgg ccggcgaggg ctcaggctcc gtttcacttg cgctgcacct gcagccactg      300

cgctctgctg ctggggccgc cgccctggct ttgaccgtgg acctgccacc cgcctcctcc      360

gaggctcgga actcggcctt cggtttccag ggccgcttgc tgcacctgag tgccggccag      420

cgcctgggcg tccatcttca cactgaggcc agggcacgcc atgcctggca gcttacccag      480

ggcgccacag tcttgggact cttccgggtg acccccgaaa tcccagccgg actcccttca      540

ccgaggtcgg aa                                                          552


<210> 262
<211> 165
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD137"

<400> 262
Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile 
                165 


<210> 263
<211> 495
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="CD137"

<400> 263
gatcccgccg gcctcttgga cctgcggcag ggcatgtttg cgcagctggt ggcccaaaat       60

gttctgctga tcgatgggcc cctgagctgg tacagtgacc caggcctggc aggcgtgtcc      120

ctgacggggg gcctgagcta caaagaggac acgaaggagc tggtggtggc caaggctgga      180

gtctactatg tcttctttca actagagctg cggcgcgtgg tggccggcga gggctcaggc      240

tccgtttcac ttgcgctgca cctgcagcca ctgcgctctg ctgctggggc cgccgccctg      300

gctttgaccg tggacctgcc acccgcctcc tccgaggctc ggaactcggc cttcggtttc      360

cagggccgct tgctgcacct gagtgccggc cagcgcctgg gcgtccatct tcacactgag      420

gccagggcac gccatgcctg gcagcttacc cagggcgcca cagtcttggg actcttccgg      480

gtgacccccg aaatc                                                       495


<210> 264

<400> 264
000


<210> 265

<400> 265
000


<210> 266

<400> 266
000


<210> 267

<400> 267
000


<210> 268
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21CD137 sequence"

<400> 268
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
    130                 135                 140                 


Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
145                 150                 155                 160 


Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
                165                 170                 175     


Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
            180                 185                 190         


Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
    210                 215                 220                 


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
225                 230                 235                 240 


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
                245                 250                 255     


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
            260                 265                 270         


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
        275                 280                 285             


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
    290                 295                 300                 


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
305                 310                 315                 320 


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
                325                 330                 335     


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
            340                 345                 350         


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
        355                 360                 365             


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
    370                 375                 380                 


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
385                 390                 395         


<210> 269
<211> 1191
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21CD137 sequence"

<400> 269
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcca ttacatgccc ccctcccatg      420

agcgtggagc acgccgacat ctgggtgaag agctatagcc tctacagccg ggagaggtat      480

atctgtaaca gcggcttcaa gaggaaggcc ggcaccagca gcctcaccga gtgcgtgctg      540

aataaggcta ccaacgtggc tcactggaca acaccctctt taaagtgcat ccggggcggt      600

ggaggatccg gaggaggtgg ctccggcggc ggaggatctc gcgagggtcc cgagctttcg      660

cccgacgatc ccgccggcct cttggacctg cggcagggca tgtttgcgca gctggtggcc      720

caaaatgttc tgctgatcga tgggcccctg agctggtaca gtgacccagg cctggcaggc      780

gtgtccctga cggggggcct gagctacaaa gaggacacga aggagctggt ggtggccaag      840

gctggagtct actatgtctt ctttcaacta gagctgcggc gcgtggtggc cggcgagggc      900

tcaggctccg tttcacttgc gctgcacctg cagccactgc gctctgctgc tggggccgcc      960

gccctggctt tgaccgtgga cctgccaccc gcctcctccg aggctcggaa ctcggccttc     1020

ggtttccagg gccgcttgct gcacctgagt gccggccagc gcctgggcgt ccatcttcac     1080

actgaggcca gggcacgcca tgcctggcag cttacccagg gcgccacagt cttgggactc     1140

ttccgggtga cccccgaaat cccagccgga ctcccttcac cgaggtcgga a              1191


<210> 270
<211> 415
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21CD137 sequence"

<400> 270
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp 
225                 230                 235                 240 


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                245                 250                 255     


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            260                 265                 270         


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        275                 280                 285             


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    290                 295                 300                 


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
305                 310                 315                 320 


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                325                 330                 335     


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            340                 345                 350         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        355                 360                 365             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    370                 375                 380                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
385                 390                 395                 400 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                405                 410                 415 


<210> 271
<211> 1245
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21CD137 sequence"

<400> 271
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tccattacat gcccccctcc catgagcgtg      480

gagcacgccg acatctgggt gaagagctat agcctctaca gccgggagag gtatatctgt      540

aacagcggct tcaagaggaa ggccggcacc agcagcctca ccgagtgcgt gctgaataag      600

gctaccaacg tggctcactg gacaacaccc tctttaaagt gcatccgggg cggtggagga      660

tccggaggag gtggctccgg cggcggagga tctcgcgagg gtcccgagct ttcgcccgac      720

gatcccgccg gcctcttgga cctgcggcag ggcatgtttg cgcagctggt ggcccaaaat      780

gttctgctga tcgatgggcc cctgagctgg tacagtgacc caggcctggc aggcgtgtcc      840

ctgacggggg gcctgagcta caaagaggac acgaaggagc tggtggtggc caaggctgga      900

gtctactatg tcttctttca actagagctg cggcgcgtgg tggccggcga gggctcaggc      960

tccgtttcac ttgcgctgca cctgcagcca ctgcgctctg ctgctggggc cgccgccctg     1020

gctttgaccg tggacctgcc acccgcctcc tccgaggctc ggaactcggc cttcggtttc     1080

cagggccgct tgctgcacct gagtgccggc cagcgcctgg gcgtccatct tcacactgag     1140

gccagggcac gccatgcctg gcagcttacc cagggcgcca cagtcttggg actcttccgg     1200

gtgacccccg aaatcccagc cggactccct tcaccgaggt cggaa                     1245


<210> 272
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21CD137 sequence"

<400> 272
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
    130                 135                 140                 


Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
145                 150                 155                 160 


Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
                165                 170                 175     


Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
            180                 185                 190         


Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
    210                 215                 220                 


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
225                 230                 235                 240 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
                245                 250                 255     


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
            260                 265                 270         


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
        275                 280                 285             


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
    290                 295                 300                 


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
305                 310                 315                 320 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
                325                 330                 335     


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
            340                 345                 350         


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
        355                 360                 365             


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
    370                 375             


<210> 273
<211> 1134
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21CD137 sequence"

<400> 273
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcca ttacatgccc ccctcccatg      420

agcgtggagc acgccgacat ctgggtgaag agctatagcc tctacagccg ggagaggtat      480

atctgtaaca gcggcttcaa gaggaaggcc ggcaccagca gcctcaccga gtgcgtgctg      540

aataaggcta ccaacgtggc tcactggaca acaccctctt taaagtgcat ccggggcggt      600

ggaggatccg gaggaggtgg ctccggcggc ggaggatctg atcccgccgg cctcttggac      660

ctgcggcagg gcatgtttgc gcagctggtg gcccaaaatg ttctgctgat cgatgggccc      720

ctgagctggt acagtgaccc aggcctggca ggcgtgtccc tgacgggggg cctgagctac      780

aaagaggaca cgaaggagct ggtggtggcc aaggctggag tctactatgt cttctttcaa      840

ctagagctgc ggcgcgtggt ggccggcgag ggctcaggct ccgtttcact tgcgctgcac      900

ctgcagccac tgcgctctgc tgctggggcc gccgccctgg ctttgaccgt ggacctgcca      960

cccgcctcct ccgaggctcg gaactcggcc ttcggtttcc agggccgctt gctgcacctg     1020

agtgccggcc agcgcctggg cgtccatctt cacactgagg ccagggcacg ccatgcctgg     1080

cagcttaccc agggcgccac agtcttggga ctcttccggg tgacccccga aatc           1134


<210> 274
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21CD137 sequence"

<400> 274
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg 
225                 230                 235                 240 


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                245                 250                 255     


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            260                 265                 270         


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        275                 280                 285             


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    290                 295                 300                 


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
305                 310                 315                 320 


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                325                 330                 335     


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            340                 345                 350         


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        355                 360                 365             


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    370                 375                 380                 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
385                 390                 395     


<210> 275
<211> 1188
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21CD137 sequence"

<400> 275
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tccattacat gcccccctcc catgagcgtg      480

gagcacgccg acatctgggt gaagagctat agcctctaca gccgggagag gtatatctgt      540

aacagcggct tcaagaggaa ggccggcacc agcagcctca ccgagtgcgt gctgaataag      600

gctaccaacg tggctcactg gacaacaccc tctttaaagt gcatccgggg cggtggagga      660

tccggaggag gtggctccgg cggcggagga tctgatcccg ccggcctctt ggacctgcgg      720

cagggcatgt ttgcgcagct ggtggcccaa aatgttctgc tgatcgatgg gcccctgagc      780

tggtacagtg acccaggcct ggcaggcgtg tccctgacgg ggggcctgag ctacaaagag      840

gacacgaagg agctggtggt ggccaaggct ggagtctact atgtcttctt tcaactagag      900

ctgcggcgcg tggtggccgg cgagggctca ggctccgttt cacttgcgct gcacctgcag      960

ccactgcgct ctgctgctgg ggccgccgcc ctggctttga ccgtggacct gccacccgcc     1020

tcctccgagg ctcggaactc ggccttcggt ttccagggcc gcttgctgca cctgagtgcc     1080

ggccagcgcc tgggcgtcca tcttcacact gaggccaggg cacgccatgc ctggcagctt     1140

acccagggcg ccacagtctt gggactcttc cgggtgaccc ccgaaatc                  1188


<210> 276

<400> 276
000


<210> 277

<400> 277
000


<210> 278

<400> 278
000


<210> 279

<400> 279
000


<210> 280

<400> 280
000


<210> 281

<400> 281
000


<210> 282

<400> 282
000


<210> 283

<400> 283
000


<210> 284

<400> 284
000


<210> 285

<400> 285
000


<210> 286

<400> 286
000


<210> 287

<400> 287
000


<210> 288

<400> 288
000


<210> 289

<400> 289
000


<210> 290

<400> 290
000


<210> 291

<400> 291
000


<210> 292

<400> 292
000


<210> 293

<400> 293
000


<210> 294

<400> 294
000


<210> 295

<400> 295
000


<210> 296

<400> 296
000


<210> 297

<400> 297
000


<210> 298

<400> 298
000


<210> 299

<400> 299
000


<210> 300
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 300
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile 
        275                 280                 285             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    290                 295                 300                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
305                 310                 315                 320 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                325                 330                 335     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            340                 345                 350         


Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
        355                 360                 365             


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
    370                 375                 380                 


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
385                 390                 395                 400 


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
                405                 410                 415     


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
            420                 425                 430         


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
        435                 440                 445             


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
    450                 455                 460                 


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
465                 470                 475                 480 


Gly Ser Glu Asp Ser 
                485 


<210> 301
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 301
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cattacatgc ccccctccca tgagcgtgga gcacgccgac      900

atctgggtga agagctatag cctctacagc cgggagaggt atatctgtaa cagcggcttc      960

aagaggaagg ccggcaccag cagcctcacc gagtgcgtgc tgaataaggc taccaacgtg     1020

gctcactgga caacaccctc tttaaagtgc atccggcagg gccaggacag gcacatgatc     1080

cggatgaggc agctcatcga catcgtcgac cagctgaaga actacgtgaa cgacctggtg     1140

cccgagtttc tgcctgcccc cgaggacgtg gagaccaact gcgagtggtc cgccttctcc     1200

tgctttcaga aggcccagct gaagtccgcc aacaccggca acaacgagcg gatcatcaac     1260

gtgagcatca agaagctgaa gcggaagcct ccctccacaa acgccggcag gaggcagaag     1320

cacaggctga cctgccccag ctgtgactcc tacgagaaga agccccccaa ggagttcctg     1380

gagaggttca agtccctgct gcagaagatg atccatcagc acctgtcctc caggacccac     1440

ggctccgagg actcc                                                      1455


<210> 302
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 302
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
    370                 375                 380                 


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
385                 390                 395                 400 


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
                405                 410                 415     


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
            420                 425                 430         


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
        435                 440                 445             


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
    450                 455                 460                 


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
465                 470                 475                 480 


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
                485                 490                 495     


Thr His Gly Ser Glu Asp Ser 
            500             


<210> 303
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 303
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacattac atgcccccct cccatgagcg tggagcacgc cgacatctgg      960

gtgaagagct atagcctcta cagccgggag aggtatatct gtaacagcgg cttcaagagg     1020

aaggccggca ccagcagcct caccgagtgc gtgctgaata aggctaccaa cgtggctcac     1080

tggacaacac cctctttaaa gtgcatccgg cagggccagg acaggcacat gatccggatg     1140

aggcagctca tcgacatcgt cgaccagctg aagaactacg tgaacgacct ggtgcccgag     1200

tttctgcctg cccccgagga cgtggagacc aactgcgagt ggtccgcctt ctcctgcttt     1260

cagaaggccc agctgaagtc cgccaacacc ggcaacaacg agcggatcat caacgtgagc     1320

atcaagaagc tgaagcggaa gcctccctcc acaaacgccg gcaggaggca gaagcacagg     1380

ctgacctgcc ccagctgtga ctcctacgag aagaagcccc ccaaggagtt cctggagagg     1440

ttcaagtccc tgctgcagaa gatgatccat cagcacctgt cctccaggac ccacggctcc     1500

gaggactcc                                                             1509


<210> 304

<400> 304
000


<210> 305

<400> 305
000


<210> 306

<400> 306
000


<210> 307

<400> 307
000


<210> 308
<211> 592
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 308
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile 
        275                 280                 285             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    290                 295                 300                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
305                 310                 315                 320 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                325                 330                 335     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            340                 345                 350         


Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
        355                 360                 365             


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
    370                 375                 380                 


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
385                 390                 395                 400 


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
                405                 410                 415     


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
            420                 425                 430         


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
        435                 440                 445             


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
465                 470                 475                 480 


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
                485                 490                 495     


Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser Trp Val 
            500                 505                 510         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp 
        515                 520                 525             


Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    530                 535                 540                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
545                 550                 555                 560 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ser 
                565                 570                 575     


Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg 
            580                 585                 590         


<210> 309
<211> 1776
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 309
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cattacatgc ccccctccca tgagcgtgga gcacgccgac      900

atctgggtga agagctatag cctctacagc cgggagaggt atatctgtaa cagcggcttc      960

aagaggaagg ccggcaccag cagcctcacc gagtgcgtgc tgaataaggc taccaacgtg     1020

gctcactgga caacaccctc tttaaagtgc atccggtccg agctgaccca ggaccctgct     1080

gtgtccgtgg ctctgggcca gaccgtgagg atcacctgcc agggcgactc cctgaggtcc     1140

tactacgcct cctggtacca gcagaagccc ggccaggctc ctgtgctggt gatctacggc     1200

aagaacaaca ggccctccgg catccctgac aggttctccg gatcctcctc cggcaacacc     1260

gcctccctga ccatcacagg cgctcaggcc gaggacgagg ctgactacta ctgcaactcc     1320

agggactcct ccggcaacca tgtggtgttc ggcggcggca ccaagctgac cgtgggccat     1380

ggcggcggcg gctccggagg cggcggcagc ggcggaggag gatccgaggt gcagctggtg     1440

gagtccggag gaggagtggt gaggcctgga ggctccctga ggctgagctg tgctgcctcc     1500

ggcttcacct tcgacgacta cggcatgtcc tgggtgaggc aggctcctgg aaagggcctg     1560

gagtgggtgt ccggcatcaa ctggaacggc ggatccaccg gctacgccga ttccgtgaag     1620

ggcaggttca ccatcagcag ggacaacgcc aagaactccc tgtacctgca gatgaactcc     1680

ctgagggccg aggacaccgc cgtgtactac tgcgccaggg gcaggtccct gctgttcgac     1740

tactggggac agggcaccct ggtgaccgtg tccagg                               1776


<210> 310
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 310
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
    370                 375                 380                 


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 
385                 390                 395                 400 


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
                405                 410                 415     


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
            420                 425                 430         


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
        435                 440                 445             


Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn 
    450                 455                 460                 


His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                485                 490                 495     


Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg 
            500                 505                 510         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser 
        515                 520                 525             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile 
    530                 535                 540                 


Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg 
545                 550                 555                 560 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
                565                 570                 575     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
            580                 585                 590         


Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        595                 600                 605             


Ser Arg 
    610 


<210> 311
<211> 1830
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 311
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacattac atgcccccct cccatgagcg tggagcacgc cgacatctgg      960

gtgaagagct atagcctcta cagccgggag aggtatatct gtaacagcgg cttcaagagg     1020

aaggccggca ccagcagcct caccgagtgc gtgctgaata aggctaccaa cgtggctcac     1080

tggacaacac cctctttaaa gtgcatccgg tccgagctga cccaggaccc tgctgtgtcc     1140

gtggctctgg gccagaccgt gaggatcacc tgccagggcg actccctgag gtcctactac     1200

gcctcctggt accagcagaa gcccggccag gctcctgtgc tggtgatcta cggcaagaac     1260

aacaggccct ccggcatccc tgacaggttc tccggatcct cctccggcaa caccgcctcc     1320

ctgaccatca caggcgctca ggccgaggac gaggctgact actactgcaa ctccagggac     1380

tcctccggca accatgtggt gttcggcggc ggcaccaagc tgaccgtggg ccatggcggc     1440

ggcggctccg gaggcggcgg cagcggcgga ggaggatccg aggtgcagct ggtggagtcc     1500

ggaggaggag tggtgaggcc tggaggctcc ctgaggctga gctgtgctgc ctccggcttc     1560

accttcgacg actacggcat gtcctgggtg aggcaggctc ctggaaaggg cctggagtgg     1620

gtgtccggca tcaactggaa cggcggatcc accggctacg ccgattccgt gaagggcagg     1680

ttcaccatca gcagggacaa cgccaagaac tccctgtacc tgcagatgaa ctccctgagg     1740

gccgaggaca ccgccgtgta ctactgcgcc aggggcaggt ccctgctgtt cgactactgg     1800

ggacagggca ccctggtgac cgtgtccagg                                      1830


<210> 312

<400> 312
000


<210> 313

<400> 313
000


<210> 314

<400> 314
000


<210> 315

<400> 315
000


<210> 316
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 316
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile 
        275                 280                 285             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    290                 295                 300                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
305                 310                 315                 320 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                325                 330                 335     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
        355                 360                 365             


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
    370                 375                 380                 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
385                 390                 395                 400 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
                405                 410                 415     


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
            420                 425                 430         


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
        435                 440                 445             


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
    450                 455                 460                 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
465                 470                 475                 480 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                485                 490                 495     


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
            500                 505                 510         


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
        515                 520                 525             


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
    530                 535                 540                 


Leu Pro Ser Pro Arg Ser Glu 
545                 550     


<210> 317
<211> 1653
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 317
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cattacatgc ccccctccca tgagcgtgga gcacgccgac      900

atctgggtga agagctatag cctctacagc cgggagaggt atatctgtaa cagcggcttc      960

aagaggaagg ccggcaccag cagcctcacc gagtgcgtgc tgaataaggc taccaacgtg     1020

gctcactgga caacaccctc tttaaagtgc atccggggcg gtggaggatc cggaggaggt     1080

ggctccggcg gcggaggatc tcgcgagggt cccgagcttt cgcccgacga tcccgccggc     1140

ctcttggacc tgcggcaggg catgtttgcg cagctggtgg cccaaaatgt tctgctgatc     1200

gatgggcccc tgagctggta cagtgaccca ggcctggcag gcgtgtccct gacggggggc     1260

ctgagctaca aagaggacac gaaggagctg gtggtggcca aggctggagt ctactatgtc     1320

ttctttcaac tagagctgcg gcgcgtggtg gccggcgagg gctcaggctc cgtttcactt     1380

gcgctgcacc tgcagccact gcgctctgct gctggggccg ccgccctggc tttgaccgtg     1440

gacctgccac ccgcctcctc cgaggctcgg aactcggcct tcggtttcca gggccgcttg     1500

ctgcacctga gtgccggcca gcgcctgggc gtccatcttc acactgaggc cagggcacgc     1560

catgcctggc agcttaccca gggcgccaca gtcttgggac tcttccgggt gacccccgaa     1620

atcccagccg gactcccttc accgaggtcg gaa                                  1653


<210> 318
<211> 569
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 318
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
385                 390                 395                 400 


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                405                 410                 415     


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            420                 425                 430         


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        435                 440                 445             


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    450                 455                 460                 


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
465                 470                 475                 480 


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                485                 490                 495     


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            500                 505                 510         


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        515                 520                 525             


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    530                 535                 540                 


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
545                 550                 555                 560 


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                565                 


<210> 319
<211> 1707
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 319
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacattac atgcccccct cccatgagcg tggagcacgc cgacatctgg      960

gtgaagagct atagcctcta cagccgggag aggtatatct gtaacagcgg cttcaagagg     1020

aaggccggca ccagcagcct caccgagtgc gtgctgaata aggctaccaa cgtggctcac     1080

tggacaacac cctctttaaa gtgcatccgg ggcggtggag gatccggagg aggtggctcc     1140

ggcggcggag gatctcgcga gggtcccgag ctttcgcccg acgatcccgc cggcctcttg     1200

gacctgcggc agggcatgtt tgcgcagctg gtggcccaaa atgttctgct gatcgatggg     1260

cccctgagct ggtacagtga cccaggcctg gcaggcgtgt ccctgacggg gggcctgagc     1320

tacaaagagg acacgaagga gctggtggtg gccaaggctg gagtctacta tgtcttcttt     1380

caactagagc tgcggcgcgt ggtggccggc gagggctcag gctccgtttc acttgcgctg     1440

cacctgcagc cactgcgctc tgctgctggg gccgccgccc tggctttgac cgtggacctg     1500

ccacccgcct cctccgaggc tcggaactcg gccttcggtt tccagggccg cttgctgcac     1560

ctgagtgccg gccagcgcct gggcgtccat cttcacactg aggccagggc acgccatgcc     1620

tggcagctta cccagggcgc cacagtcttg ggactcttcc gggtgacccc cgaaatccca     1680

gccggactcc cttcaccgag gtcggaa                                         1707


<210> 320
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18s sequence"

<400> 320
atgaagtggg tcacatttat ctctttactg ttcctcttct ccagcgccta cagctacttc       60

ggcaaactgg aatccaagct gagcgtgatc cggaatttaa acgaccaagt tctgtttatc      120

gatcaaggta accggcctct gttcgaggac atgaccgact ccgattgccg ggacaatgcc      180

ccccggacca tcttcattat ctccatgtac aaggacagcc agccccgggg catggctgtg      240

acaattagcg tgaagtgtga gaaaatcagc actttatctt gtgagaacaa gatcatctcc      300

tttaaggaaa tgaacccccc cgataacatc aaggacacca agtccgatat catcttcttc      360

cagcggtccg tgcccggtca cgataacaag atgcagttcg aatcctcctc ctacgagggc      420

tactttttag cttgtgaaaa ggagagggat ttattcaagc tgatcctcaa gaaggaggac      480

gagctgggcg atcgttccat catgttcacc gtccaaaacg aggatattac atgcccccct      540

cccatgagcg tggagcacgc cgacatctgg gtgaagagct atagcctcta cagccgggag      600

aggtatatct gtaacagcgg cttcaagagg aaggccggca ccagcagcct caccgagtgc      660

gtgctgaata aggctaccaa cgtggctcac tggacaacac cctctttaaa gtgcatccgg      720


<210> 321
<211> 2607
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      12t15 sequence"

<400> 321
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctccatttgg       60

gaactgaaga aggacgtcta cgtggtcgaa ctggactggt atcccgatgc tcccggcgaa      120

atggtggtgc tcacttgtga cacccccgaa gaagacggca tcacttggac cctcgatcag      180

agcagcgagg tgctgggctc cggaaagacc ctcacaatcc aagttaagga gttcggagac      240

gctggccaat acacatgcca caagggaggc gaggtgctca gccattcctt attattatta      300

cacaagaagg aagacggaat ctggtccacc gacattttaa aagatcagaa ggagcccaag      360

aataagacct ttttaaggtg tgaggccaaa aactacagcg gtcgtttcac ttgttggtgg      420

ctgaccacca tttccaccga tttaaccttc tccgtgaaaa gcagccgggg aagctccgac      480

cctcaaggtg tgacatgtgg agccgctacc ctcagcgctg agagggttcg tggcgataac      540

aaggaatacg agtacagcgt ggagtgccaa gaagatagcg cttgtcccgc tgccgaagaa      600

tctttaccca ttgaggtgat ggtggacgcc gtgcacaaac tcaagtacga gaactacacc      660

tcctccttct ttatccggga catcattaag cccgatcctc ctaagaattt acagctgaag      720

cctctcaaaa atagccggca agttgaggtc tcttgggaat atcccgacac ttggagcaca      780

ccccacagct acttctcttt aaccttttgt gtgcaagttc aaggtaaaag caagcgggag      840

aagaaagacc gggtgtttac cgacaaaacc agcgccaccg tcatctgtcg gaagaacgcc      900

tccatcagcg tgagggctca agatcgttat tactccagca gctggtccga gtgggccagc      960

gtgccttgtt ccggcggtgg aggatccgga ggaggtggct ccggcggcgg aggatctcgt     1020

aacctccccg tggctacccc cgatcccgga atgttccctt gtttacacca cagccagaat     1080

ttactgaggg ccgtgagcaa catgctgcag aaagctaggc agactttaga attttaccct     1140

tgcaccagcg aggagatcga ccatgaagat atcaccaagg acaagacatc caccgtggag     1200

gcttgtttac ctctggagct gacaaagaac gagtcttgtc tcaactctcg tgaaaccagc     1260

ttcatcacaa atggctcttg tttagcttcc cggaagacct cctttatgat ggctttatgc     1320

ctcagctcca tctacgagga tttaaagatg taccaagtgg agttcaagac catgaacgcc     1380

aagctgctca tggaccctaa acggcagatc tttttagacc agaacatgct ggctgtgatt     1440

gatgagctga tgcaagcttt aaacttcaac tccgagaccg tccctcagaa gtcctccctc     1500

gaggagcccg atttttacaa gacaaagatc aaactgtgca ttttactcca cgcctttagg     1560

atccgggccg tgaccattga ccgggtcatg agctatttaa acgccagcag cggcacaacc     1620

aacacagtcg ctgcctataa cctcacttgg aagagcacca acttcaaaac catcctcgaa     1680

tgggaaccca aacccgttaa ccaagtttac accgtgcaga tcagcaccaa gtccggcgac     1740

tggaagtcca aatgtttcta taccaccgac accgagtgcg atctcaccga tgagatcgtg     1800

aaagatgtga aacagaccta cctcgcccgg gtgtttagct accccgccgg caatgtggag     1860

agcactggtt ccgctggcga gcctttatac gagaacagcc ccgaatttac cccttacctc     1920

gagaccaatt taggacagcc caccatccaa agctttgagc aagttggcac aaaggtgaat     1980

gtgacagtgg aggacgagcg gactttagtg cggcggaaca acacctttct cagcctccgg     2040

gatgtgttcg gcaaagattt aatctacaca ctgtattact ggaagtcctc ttcctccggc     2100

aagaagacag ctaaaaccaa cacaaacgag tttttaatcg acgtggataa aggcgaaaac     2160

tactgtttca gcgtgcaagc tgtgatcccc tcccggaccg tgaataggaa aagcaccgat     2220

agccccgttg agtgcatggg ccaagaaaag ggcgagttcc gggagaactg ggtgaacgtc     2280

atcagcgatt taaagaagat cgaagattta attcagtcca tgcatatcga cgccacttta     2340

tacacagaat ccgacgtgca cccctcttgt aaggtgaccg ccatgaaatg ttttttactg     2400

gagctgcaag ttatctcttt agagagcgga gacgctagca tccacgacac cgtggagaat     2460

ttaatcattt tagccaataa ctctttatcc agcaacggca acgtgacaga gtccggctgc     2520

aaggagtgcg aagagctgga ggagaagaac atcaaggagt ttctgcaatc ctttgtgcac     2580

attgtccaga tgttcatcaa tacctcc                                         2607


<210> 322
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18s sequence"

<400> 322
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn 
            20                  25                  30          


Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe 
        35                  40                  45              


Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile 
    50                  55                  60                  


Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val 
65                  70                  75                  80  


Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn 
                85                  90                  95      


Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp 
            100                 105                 110         


Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp 
        115                 120                 125             


Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala 
    130                 135                 140                 


Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp 
145                 150                 155                 160 


Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


<210> 323
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      12t15 sequence"

<400> 323
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp 
            20                  25                  30          


Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr 
        35                  40                  45              


Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val 
    50                  55                  60                  


Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp 
65                  70                  75                  80  


Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser 
                85                  90                  95      


Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile 
            100                 105                 110         


Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu 
        115                 120                 125             


Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile 
    130                 135                 140                 


Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp 
145                 150                 155                 160 


Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val 
                165                 170                 175     


Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp 
            180                 185                 190         


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val 
        195                 200                 205             


Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
    210                 215                 220                 


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
            260                 265                 270         


Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp 
        275                 280                 285             


Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val 
    290                 295                 300                 


Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
305                 310                 315                 320 


Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            340                 345                 350         


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        355                 360                 365             


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    370                 375                 380                 


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
385                 390                 395                 400 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                405                 410                 415     


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            420                 425                 430         


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
        435                 440                 445             


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    450                 455                 460                 


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
465                 470                 475                 480 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                485                 490                 495     


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            500                 505                 510         


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        515                 520                 525             


Val Met Ser Tyr Leu Asn Ala Ser Ser Gly Thr Thr Asn Thr Val Ala 
    530                 535                 540                 


Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu 
545                 550                 555                 560 


Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr 
                565                 570                 575     


Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu 
            580                 585                 590         


Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu 
        595                 600                 605             


Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser 
    610                 615                 620                 


Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu 
625                 630                 635                 640 


Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly 
                645                 650                 655     


Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg 
            660                 665                 670         


Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile 
        675                 680                 685             


Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala 
    690                 695                 700                 


Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn 
705                 710                 715                 720 


Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg 
                725                 730                 735     


Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu 
            740                 745                 750         


Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
        755                 760                 765             


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
    770                 775                 780                 


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
785                 790                 795                 800 


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
                805                 810                 815     


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
            820                 825                 830         


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
        835                 840                 845             


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
    850                 855                 860                 


Phe Ile Asn Thr Ser 
865                 


<210> 324
<211> 1452
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15 sequence"

<400> 324
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tcctccggca ccaccaatac cgtggccgct      480

tataacctca catggaagag caccaacttc gcgacagctc tggaatggga acccaagccc      540

gtcaatcaag tttacaccgt gcagatctcc accaaatccg gagactggaa gagcaagtgc      600

ttctacacaa cagacaccga gtgtgcttta accgacgaaa tcgtcaagga cgtcaagcaa      660

acctatctgg ctcgggtctt ttcctacccc gctggcaatg tcgagtccac cggctccgct      720

ggcgagcctc tctacgagaa ttcccccgaa ttcacccctt atttagagac caatttaggc      780

cagcctacca tccagagctt cgagcaagtt ggcaccaagg tgaacgtcac cgtcgaggat      840

gaaaggactt tagtggcgcg gaataacaca gctttatccc tccgggatgt gttcggcaaa      900

gacctcatct acacactgta ctattggaag tccagctcct ccggcaaaaa gaccgctaag      960

accaacacca acgagttttt aattgacgtg gacaaaggcg agaactactg cttcagcgtg     1020

caagccgtga tcccttctcg taccgtcaac cggaagagca cagattcccc cgttgagtgc     1080

atgggccaag aaaagggcga gttccgggag aactgggtga acgtcatcag cgatttaaag     1140

aagatcgaag atttaattca gtccatgcat atcgacgcca ctttatacac agaatccgac     1200

gtgcacccct cttgtaaggt gaccgccatg aaatgttttt tactggagct gcaagttatc     1260

tctttagaga gcggagacgc tagcatccac gacaccgtgg agaatttaat cattttagcc     1320

aataactctt tatccagcaa cggcaacgtg acagagtccg gctgcaagga gtgcgaagag     1380

ctggaggaga agaacatcaa ggagtttctg caatcctttg tgcacattgt ccagatgttc     1440

atcaatacct cc                                                         1452


<210> 325
<211> 484
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15 sequence"

<400> 325
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ser Gly Thr Thr Asn Thr Val Ala Ala 
145                 150                 155                 160 


Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Ala Thr Ala Leu Glu Trp 
                165                 170                 175     


Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys 
            180                 185                 190         


Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys 
        195                 200                 205             


Ala Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala 
    210                 215                 220                 


Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala 
225                 230                 235                 240 


Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu 
                245                 250                 255     


Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr 
            260                 265                 270         


Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Ala Arg Asn 
        275                 280                 285             


Asn Thr Ala Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr 
    290                 295                 300                 


Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys 
305                 310                 315                 320 


Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr 
                325                 330                 335     


Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys 
            340                 345                 350         


Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe 
        355                 360                 365             


Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
    370                 375                 380                 


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
385                 390                 395                 400 


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
                405                 410                 415     


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
            420                 425                 430         


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
        435                 440                 445             


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
    450                 455                 460                 


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
465                 470                 475                 480 


Ile Asn Thr Ser 
                


<210> 326
<211> 2142
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD28tCD3 sequence"

<400> 326
atgaaatggg tcaccttcat ctctttactg tttttattta gcagcgccta cagcgtgcag       60

ctgcagcagt ccggacccga actggtcaag cccggtgcct ccgtgaaaat gtcttgtaag      120

gcttctggct acacctttac ctcctacgtc atccaatggg tgaagcagaa gcccggtcaa      180

ggtctcgagt ggatcggcag catcaatccc tacaacgatt acaccaagta taacgaaaag      240

tttaagggca aggccactct gacaagcgac aagagctcca ttaccgccta catggagttt      300

tcctctttaa cttctgagga ctccgcttta tactattgcg ctcgttgggg cgatggcaat      360

tattggggcc ggggaactac tttaacagtg agctccggcg gcggcggaag cggaggtgga      420

ggatctggcg gtggaggcag cgacatcgag atgacacagt cccccgctat catgagcgcc      480

tctttaggag aacgtgtgac catgacttgt acagcttcct ccagcgtgag cagctcctat      540

ttccactggt accagcagaa acccggctcc tcccctaaac tgtgtatcta ctccacaagc      600

aatttagcta gcggcgtgcc tcctcgtttt agcggctccg gcagcacctc ttactcttta      660

accattagct ctatggaggc cgaagatgcc gccacatact tttgccatca gtaccaccgg      720

tcccctacct ttggcggagg cacaaagctg gagaccaagc ggagcggcac caccaacaca      780

gtggccgcct acaatctgac ttggaaatcc accaacttca agaccatcct cgagtgggag      840

cccaagcccg ttaatcaagt ttataccgtg cagatttcca ccaagagcgg cgactggaaa      900

tccaagtgct tctataccac agacaccgag tgcgatctca ccgacgagat cgtcaaagac      960

gtgaagcaga catatttagc tagggtgttc tcctaccccg ctggaaacgt ggagagcacc     1020

ggatccgctg gagagccttt atacgagaac tcccccgaat tcacccccta tctggaaacc     1080

aatttaggcc agcccaccat ccagagcttc gaacaagttg gcacaaaggt gaacgtcacc     1140

gtcgaagatg agaggacttt agtgcggagg aacaatacat ttttatcctt acgtgacgtc     1200

ttcggcaagg atttaatcta cacactgtat tactggaagt ctagctcctc cggcaagaag     1260

accgccaaga ccaataccaa cgaattttta attgacgtgg acaagggcga gaactactgc     1320

ttctccgtgc aagctgtgat cccctcccgg acagtgaacc ggaagtccac cgactccccc     1380

gtggagtgca tgggccaaga gaagggagag tttcgtgagc agatcgtgct gacccagtcc     1440

cccgctatta tgagcgctag ccccggtgaa aaggtgacta tgacatgcag cgccagctct     1500

tccgtgagct acatgaactg gtatcagcag aagtccggca ccagccctaa aaggtggatc     1560

tacgacacca gcaagctggc cagcggcgtc cccgctcact ttcggggctc cggctccgga     1620

acaagctact ctctgaccat cagcggcatg gaagccgagg atgccgctac ctattactgt     1680

cagcagtgga gctccaaccc cttcaccttt ggatccggca ccaagctcga gattaatcgt     1740

ggaggcggag gtagcggagg aggcggatcc ggcggtggag gtagccaagt tcagctccag     1800

caaagcggcg ccgaactcgc tcggcccggc gcttccgtga agatgtcttg taaggcctcc     1860

ggctatacct tcacccggta cacaatgcac tgggtcaagc aacggcccgg tcaaggttta     1920

gagtggattg gctatatcaa cccctcccgg ggctatacca actacaacca gaagttcaag     1980

gacaaagcca ccctcaccac cgacaagtcc agcagcaccg cttacatgca gctgagctct     2040

ttaacatccg aggattccgc cgtgtactac tgcgctcggt actacgacga tcattactgc     2100

ctcgattact ggggccaagg taccacctta acagtctcct cc                        2142


<210> 327
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD28tCD3 sequence"

<400> 327
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
            20                  25                  30          


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
        35                  40                  45              


Tyr Val Ile Gln Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp 
    50                  55                  60                  


Ile Gly Ser Ile Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys 
65                  70                  75                  80  


Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala 
                85                  90                  95      


Tyr Met Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Trp Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu 
        115                 120                 125             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala 
145                 150                 155                 160 


Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Ser Ser Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
            180                 185                 190         


Lys Leu Cys Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
    210                 215                 220                 


Met Glu Ala Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg 
225                 230                 235                 240 


Ser Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg Ser Gly 
                245                 250                 255     


Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn 
            260                 265                 270         


Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr 
        275                 280                 285             


Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe 
    290                 295                 300                 


Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp 
305                 310                 315                 320 


Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn 
                325                 330                 335     


Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro 
            340                 345                 350         


Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln 
        355                 360                 365             


Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu 
    370                 375                 380                 


Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val 
385                 390                 395                 400 


Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser 
                405                 410                 415     


Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp 
            420                 425                 430         


Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro 
        435                 440                 445             


Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met 
    450                 455                 460                 


Gly Gln Glu Lys Gly Glu Phe Arg Glu Gln Ile Val Leu Thr Gln Ser 
465                 470                 475                 480 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                485                 490                 495     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
            500                 505                 510         


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
        515                 520                 525             


Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    530                 535                 540                 


Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
545                 550                 555                 560 


Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
                565                 570                 575     


Glu Ile Asn Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
        595                 600                 605             


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    610                 615                 620                 


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
625                 630                 635                 640 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                645                 650                 655     


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
            660                 665                 670         


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
        675                 680                 685             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
    690                 695                 700                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
705                 710                 


<210> 328
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 328
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210> 329
<211> 454
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="Myc"

<400> 329
Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210> 330
<211> 1365
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="Myc"

<400> 330
ctggattttt ttcgggtagt ggaaaaccag cagcctcccg cgacgatgcc cctcaacgtt       60

agcttcacca acaggaacta tgacctcgac tacgactcgg tgcagccgta tttctactgc      120

gacgaggagg agaacttcta ccagcagcag cagcagagcg agctgcagcc cccggcgccc      180

agcgaggata tctggaagaa attcgagctg ctgcccaccc cgcccctgtc ccctagccgc      240

cgctccgggc tctgctcgcc ctcctacgtt gcggtcacac ccttctccct tcggggagac      300

aacgacggcg gtggcgggag cttctccacg gccgaccagc tggagatggt gaccgagctg      360

ctgggaggag acatggtgaa ccagagtttc atctgcgacc cggacgacga gaccttcatc      420

aaaaacatca tcatccagga ctgtatgtgg agcggcttct cggccgccgc caagctcgtc      480

tcagagaagc tggcctccta ccaggctgcg cgcaaagaca gcggcagccc gaaccccgcc      540

cgcggccaca gcgtctgctc cacctccagc ttgtacctgc aggatctgag cgccgccgcc      600

tcagagtgca tcgacccctc ggtggtcttc ccctaccctc tcaacgacag cagctcgccc      660

aagtcctgcg cctcgcaaga ctccagcgcc ttctctccgt cctcggattc tctgctctcc      720

tcgacggagt cctccccgca gggcagcccc gagcccctgg tgctccatga ggagacaccg      780

cccaccacca gcagcgactc tgaggaggaa caagaagatg aggaagaaat cgatgttgtt      840

tctgtggaaa agaggcaggc tcctggcaaa aggtcagagt ctggatcacc ttctgctgga      900

ggccacagca aacctcctca cagcccactg gtcctcaaga ggtgccacgt ctccacacat      960

cagcacaact acgcagcgcc tccctccact cggaaggact atcctgctgc caagagggtc     1020

aagttggaca gtgtcagagt cctgagacag atcagcaaca accgaaaatg caccagcccc     1080

aggtcctcgg acaccgagga gaatgtcaag aggcgaacac acaacgtctt ggagcgccag     1140

aggaggaacg agctaaaacg gagctttttt gccctgcgtg accagatccc ggagttggaa     1200

aacaatgaaa aggcccccaa ggtagttatc cttaaaaaag ccacagcata catcctgtcc     1260

gtccaagcag aggagcaaaa gctcatttct gaagaggact tgttgcggaa acgacgagaa     1320

cagttgaaac acaaacttga acagctacgg aactcttgtg cgtaa                     1365


<210> 331
<211> 1245
<212> DNA
<213> Homo sapiens 

<220>
<221> source
<223> /note="21s137L"

<400> 331
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tccattacat gcccccctcc catgagcgtg      480

gagcacgccg acatctgggt gaagagctat agcctctaca gccgggagag gtatatctgt      540

aacagcggct tcaagaggaa ggccggcacc agcagcctca ccgagtgcgt gctgaataag      600

gctaccaacg tggctcactg gacaacaccc tctttaaagt gcatccgggg cggtggagga      660

tccggaggag gtggctccgg cggcggagga tctcgcgagg gtcccgagct ttcgcccgac      720

gatcccgccg gcctcttgga cctgcggcag ggcatgtttg cgcagctggt ggcccaaaat      780

gttctgctga tcgatgggcc cctgagctgg tacagtgacc caggcctggc aggcgtgtcc      840

ctgacggggg gcctgagcta caaagaggac acgaaggagc tggtggtggc caaggctgga      900

gtctactatg tcttctttca actagagctg cggcgcgtgg tggccggcga gggctcaggc      960

tccgtttcac ttgcgctgca cctgcagcca ctgcgctctg ctgctggggc cgccgccctg     1020

gctttgaccg tggacctgcc acccgcctcc tccgaggctc ggaactcggc cttcggtttc     1080

cagggccgct tgctgcacct gagtgccggc cagcgcctgg gcgtccatct tcacactgag     1140

gccagggcac gccatgcctg gcagcttacc cagggcgcca cagtcttggg actcttccgg     1200

gtgacccccg aaatcccagc cggactccct tcaccgaggt cggaa                     1245


<210> 332
<211> 415
<212> PRT
<213> Homo sapiens 

<220>
<221> source
<223> /note="21s137L"

<400> 332
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp 
225                 230                 235                 240 


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                245                 250                 255     


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            260                 265                 270         


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        275                 280                 285             


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    290                 295                 300                 


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
305                 310                 315                 320 


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                325                 330                 335     


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            340                 345                 350         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        355                 360                 365             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    370                 375                 380                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
385                 390                 395                 400 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                405                 410                 415 


<210> 333
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 333
ggtgggtata atggg                                                        15


<210> 334
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 334
attattttat tttaaaaaat ttgtg                                             25


