                         SEQUENCE LISTING

<110>  YALE UNIVERSITY
       QUIJANO, ELIAS
       TURCHICK, AUDREY
       GLAZER, PETER
 
<120>  COMPOSITIONS AND METHODS FOR ENHANCING DONOR 
       OLIGONUCLEOTIDE-BASED GENE EDITING

<130>  YU7503PCT

<150>  62/725,920
<151>  2018-08-31

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  3

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  4
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  5
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  5

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  6
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  7
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  7

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  8
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe His Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  9
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  10
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  11
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  11

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  12
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  12

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  13
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  13

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  14
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  14

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  15

Asp Tyr Gly Met His 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  16

Asn Tyr Gly Met His 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  17

Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  18

Arg Gly Leu Leu Leu Asp Tyr 
1               5           


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  19

Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  20

Gly Phe Thr Phe Ser Asp Tyr Gly 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  21

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  22

Ile Ser Ser Gly Ser Ser Thr Ile 
1               5               


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  23

Ala Arg Arg Gly Leu Leu Leu Asp Tyr 
1               5                   


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  24

Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  25

Tyr Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  26

Gln His Ser Arg Glu Phe Pro Trp Thr 
1               5                   


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  27

Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Leu Ala 
1               5                   10                  15  


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  28

Tyr Ala Ser Tyr Leu Gln Ser 
1               5           


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  29

Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr 
1               5                   10  


<210>  30
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  30

Tyr Ala Ser 
1           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  31

Gly Gln Ser Ser Arg Ser Ser 
1               5           


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  32

Gly Gln Ser Ser Arg Ser Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  33

Gly Ser Gly Ser 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  34

Gly Gly Gly Ser 
1               


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  35

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  36

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  37

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  38
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  38

Ala Gly Ile His Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
1               5                   10                  15      


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser 
            20                  25                  30          


Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser 
    50                  55                  60                  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Gln His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys Arg Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala 
                165                 170                 175     


Pro Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser 
            180                 185                 190         


Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser 
    210                 215                 220                 


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Leu Glu Gln Lys 
                245                 250                 255     


Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His His His His 
            260                 265                 270         


His His 
        


<210>  39
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  39

Ala Gly Ile His Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
1               5                   10                  15      


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser 
            20                  25                  30          


Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser 
    50                  55                  60                  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Gln His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys Arg Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala 
                165                 170                 175     


Pro Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser 
            180                 185                 190         


Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser 
    210                 215                 220                 


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys 
                245                 250                 255     


Gly Pro Ser Val Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp 
            260                 265                 270         


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
        275                 280                 285             


Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser 
    290                 295                 300                 


Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala Arg 
                325                 330                 335     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
            340                 345                 350         


Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
        355                 360                 365             


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
    370                 375                 380                 


Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
                405                 410                 415     


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            420                 425                 430         


Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
        435                 440                 445             


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala 
    450                 455                 460                 


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
465                 470                 475                 480 


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
                485                 490                 495     


Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Thr Leu Thr Val Ser Ser Leu Glu Gln Lys Leu Ile Ser Glu Glu 
        515                 520                 525             


Asp Leu Asn Ser Ala Val Asp His His His His His His 
    530                 535                 540     


<210>  40
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  40

Ala Gly Ile His Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
1               5                   10                  15      


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser 
            20                  25                  30          


Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser 
    50                  55                  60                  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Gln His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys Arg Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala 
                165                 170                 175     


Pro Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser 
            180                 185                 190         


Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser 
    210                 215                 220                 


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys 
                245                 250                 255     


Gly Pro Ser Val Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp 
            260                 265                 270         


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
        275                 280                 285             


Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser 
    290                 295                 300                 


Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala Arg 
                325                 330                 335     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
            340                 345                 350         


Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
        355                 360                 365             


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
    370                 375                 380                 


Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
                405                 410                 415     


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            420                 425                 430         


Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
        435                 440                 445             


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala 
    450                 455                 460                 


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
465                 470                 475                 480 


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
                485                 490                 495     


Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        515                 520                 525             


Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp Ile Val Leu Thr Gln 
    530                 535                 540                 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
545                 550                 555                 560 


Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
                565                 570                 575     


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr 
            580                 585                 590         


Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
        595                 600                 605             


Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp 
    610                 615                 620                 


Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Phe Pro Trp Thr Phe 
625                 630                 635                 640 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
            660                 665                 670         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Arg 
        675                 680                 685             


Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met 
    690                 695                 700                 


His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ala Tyr 
705                 710                 715                 720 


Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly 
                725                 730                 735     


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln 
            740                 745                 750         


Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
        755                 760                 765             


Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    770                 775                 780                 


Ser Ser Leu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala 
785                 790                 795                 800 


Val Asp His His His His His His 
                805             


<210>  41
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  41

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met 
145                 150                 155                 160 


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser Tyr 
                165                 170                 175     


Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 
    210                 215                 220                 


Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  42
<211>  6060
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  42
aaagctcttg ctttgacaat tttggtcttt cagaatacta taaatataac ctatattata       60

atttcataaa gtctgtgcat tttctttgac ccaggatatt tgcaaaagac atattcaaac      120

ttccgcagaa cactttattt cacatataca tgcctcttat atcagggatg tgaaacaggg      180

tcttgaaaac tgtctaaatc taaaacaatg ctaatgcagg tttaaattta ataaaataaa      240

atccaaaatc taacagccaa gtcaaatctg tatgttttaa catttaaaat attttaaaga      300

cgtcttttcc caggattcaa catgtgaaat cttttctcag ggatacacgt gtgcctagat      360

cctcattgct ttagtttttt acagaggaat gaatataaaa agaaaatact taaattttat      420

ccctcttacc tctataatca tacataggca taatttttta acctaggctc cagatagcca      480

tagaagaacc aaacactttc tgcgtgtgtg agaataatca gagtgagatt ttttcacaag      540

tacctgatga gggttgagac aggtagaaaa agtgagagat ctctatttat ttagcaataa      600

tagagaaagc atttaagaga ataaagcaat ggaaataaga aatttgtaaa tttccttctg      660

ataactagaa atagaggatc cagtttcttt tggttaacct aaattttatt tcattttatt      720

gttttatttt attttatttt attttatttt gtgtaatcgt agtttcagag tgttagagct      780

gaaaggaaga agtaggagaa acatgcaaag taaaagtata acactttcct tactaaaccg      840

actgggtttc caggtagggg caggattcag gatgactgac agggccctta gggaacactg      900

agaccctacg ctgacctcat aaatgcttgc tacctttgct gttttaatta catcttttaa      960

tagcaggaag cagaactctg cacttcaaaa gtttttcctc acctgaggag ttaatttagt     1020

acaaggggaa aaagtacagg gggatgggag aaaggcgatc acgttgggaa gctatagaga     1080

aagaagagta aattttagta aaggaggttt aaacaaacaa aatataaaga gaaataggaa     1140

cttgaatcaa ggaaatgatt ttaaaacgca gtattcttag tggactagag gaaaaaaata     1200

atctgagcca agtagaagac cttttcccct cctaccccta ctttctaagt cacagaggct     1260

ttttgttccc ccagacactc ttgcagatta gtccaggcag aaacagttag atgtccccag     1320

ttaacctcct atttgacacc actgattacc ccattgatag tcacactttg ggttgtaagt     1380

gactttttat ttatttgtat ttttgactgc attaagaggt ctctagtttt ttatctcttg     1440

tttcccaaaa cctaataagt aactaatgca cagagcacat tgatttgtat ttattctatt     1500

tttagacata atttattagc atgcatgagc aaattaagaa aaacaacaac aaatgaatgc     1560

atatatatgt atatgtatgt gtgtatatat acacatatat atatatattt tttttctttt     1620

cttaccagaa ggttttaatc caaataagga gaagatatgc ttagaactga ggtagagttt     1680

tcatccattc tgtcctgtaa gtattttgca tattctggag acgcaggaag agatccatct     1740

acatatccca aagctgaatt atggtagaca aagctcttcc acttttagtg catcaatttc     1800

ttatttgtgt aataagaaaa ttgggaaaac gatcttcaat atgcttacca agctgtgatt     1860

ccaaatatta cgtaaataca cttgcaaagg aggatgtttt tagtagcaat ttgtactgat     1920

ggtatggggc caagagatat atcttagagg gagggctgag ggtttgaagt ccaactccta     1980

agccagtgcc agaagagcca aggacaggta cggctgtcat cacttagacc tcaccctgtg     2040

gagccacacc ctagggttgg ccaatctact cccaggagca gggagggcag gagccagggc     2100

tgggcataaa agtcagggca gagccatcta ttgcttacat ttgcttctga cacaactgtg     2160

ttcactagca acctcaaaca gacaccatgg tgcacctgac tcctgaggag aagtctgccg     2220

ttactgccct gtggggcaag gtgaacgtgg atgaagttgg tggtgaggcc ctgggcaggt     2280

tggtatcaag gttacaagac aggtttaagg agaccaatag aaactgggca tgtggagaca     2340

gagaagactc ttgggtttct gataggcact gactctctct gcctattggt ctattttccc     2400

acccttaggc tgctggtggt ctacccttgg acccagaggt tctttgagtc ctttggggat     2460

ctgtccactc ctgatgctgt tatgggcaac cctaaggtga aggctcatgg caagaaagtg     2520

ctcggtgcct ttagtgatgg cctggctcac ctggacaacc tcaagggcac ctttgccaca     2580

ctgagtgagc tgcactgtga caagctgcac gtggatcctg agaacttcag ggtgagtcta     2640

tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag     2700

gggagaagta acagggtaca gtttagaatg ggaaacagac gaatgattgc atcagtgtgg     2760

aagtctcagg atcgttttag tttcttttat ttgctgttca taacaattgt tttcttttgt     2820

ttaattcttg ctttcttttt ttttcttctc cgcaattttt actattatac ttaatgcctt     2880

aacattgtgt ataacaaaag gaaatatctc tgagatacat taagtaactt aaaaaaaaac     2940

tttacacagt ctgcctagta cattactatt tggaatatat gtgtgcttat ttgcatattc     3000

ataatctccc tactttattt tcttttattt ttaattgata cataatcatt atacatattt     3060

atgggttaaa gtgtaatgtt ttaatatgtg tacacatatt gaccaaatca gggtaatttt     3120

gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt     3180

ctaatacttt ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct     3240

ttgcaccatt ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct     3300

gcatataaat atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata     3360

gcagctacaa tccagctacc attctgcttt tattttatgg ttgggataag gctggattat     3420

tctgagtcca agctaggccc ttttgctaat catgttcata cctcttatct tcctcccaca     3480

gctcctgggc aacgtgctgg tctgtgtgct ggcccatcac tttggcaaag aattcacccc     3540

accagtgcag gctgcctatc agaaagtggt ggctggtgtg gctaatgccc tggcccacaa     3600

gtatcactaa gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa     3660

gtccaactac taaactgggg gatattatga agggccttga gcatctggat tctgcctaat     3720

aaaaaacatt tattttcatt gcaatgatgt atttaaatta tttctgaata ttttactaaa     3780

aagggaatgt gggaggtcag tgcatttaaa acataaagaa atgaagagct agttcaaacc     3840

ttgggaaaat acactatatc ttaaactcca tgaaagaagg tgaggctgca aacagctaat     3900

gcacattggc aacagccctg atgcctatgc cttattcatc cctcagaaaa ggattcaagt     3960

agaggcttga tttggaggtt aaagttttgc tatgctgtat tttacattac ttattgtttt     4020

agctgtcctc atgaatgtct tttcactacc catttgctta tcctgcatct ctcagccttg     4080

actccactca gttctcttgc ttagagatac cacctttccc ctgaagtgtt ccttccatgt     4140

tttacggcga gatggtttct cctcgcctgg ccactcagcc ttagttgtct ctgttgtctt     4200

atagaggtct acttgaagaa ggaaaaacag ggggcatggt ttgactgtcc tgtgagccct     4260

tcttccctgc ctcccccact cacagtgacc cggaatctgc agtgctagtc tcccggaact     4320

atcactcttt cacagtctgc tttggaagga ctgggcttag tatgaaaagt taggactgag     4380

aagaatttga aagggggctt tttgtagctt gatattcact actgtcttat taccctatca     4440

taggcccacc ccaaatggaa gtcccattct tcctcaggat gtttaagatt agcattcagg     4500

aagagatcag aggtctgctg gctcccttat catgtccctt atggtgcttc tggctctgca     4560

gttattagca tagtgttacc atcaaccacc ttaacttcat ttttcttatt caatacctag     4620

gtaggtagat gctagattct ggaaataaaa tatgagtctc aagtggtcct tgtcctctct     4680

cccagtcaaa ttctgaatct agttggcaag attctgaaat caaggcatat aatcagtaat     4740

aagtgatgat agaagggtat atagaagaat tttattatat gagagggtga aacctaaaat     4800

gaaatgaaat cagacccttg tcttacacca taaacaaaaa taaatttgaa tgggttaaag     4860

aattaaacta agacctaaaa ccataaaaat ttttaaagaa atcaaaagaa gaaaattcta     4920

atattcatgt tgcagccgtt ttttgaattt gatatgagaa gcaaaggcaa caaaaggaaa     4980

aataaagaag tgaggctaca tcaaactaaa aaatttccac acaaaaaaga aaacaatgaa     5040

caaatgaaag gtgaaccatg aaatggcata tttgcaaacc aaatatttct taaatatttt     5100

ggttaatatc caaaatatat aagaaacaca gatgattcaa taacaaacaa aaaattaaaa     5160

ataggaaaat aaaaaaatta aaaagaagaa aatcctgcca tttatgcgag aattgatgaa     5220

cctggaggat gtaaaactaa gaaaaataag cctgacacaa aaagacaaat actacacaac     5280

cttgctcata tgtgaaacat aaaaaagtca ctctcatgga aacagacagt agaggtatgg     5340

tttccagggg ttgggggtgg gagaatcagg aaactattac tcaaagggta taaaatttca     5400

gttatgtggg atgaataaat tctagatatc taatgtacag catcgtgact gtagttaatt     5460

gtactgtaag tatatttaaa atttgcaaag agagtagatt tttttgtttt tttagatgga     5520

gttttgctct tgttgtccag gctggagtgc aatggcaaga tcttggctca ctgcaacctc     5580

cgcctcctgg gttcaagcaa atctcctgcc tcagcctccc gagtagctgg gattacaggc     5640

atgcgacacc atgcccagct aattttgtat ttttagtaga gacggggttt ctccatgttg     5700

gtcaggctga tccgcctcct cggccaccaa agggctggga ttacaggcgt gaccaccggg     5760

cctggccgag agtagatctt aaaagcattt accacaagaa aaaggtaact atgtgagata     5820

atgggtatgt taattagctt gattgtggta atcatttcac aaggtataca tatattaaaa     5880

catcatgttg tacaccttaa atatatacaa tttttatttg tgaatgatac ctcaataaag     5940

ttgaagaata ataaaaaaga atagacatca catgaattaa aaaactaaaa aataaaaaaa     6000

tgcatcttga tgattagaat tgcattcttg atttttcaga tacaaatatc catttgactg     6060


<210>  43
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  optional phosphorothioate internucleoside linkage

<400>  43
aaagaataac agtgataatt tctgggttaa ggcaatagca atatctctgc atataaatat       60


<210>  44
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  optional phosphorothioate internucleoside linkage

<400>  44
gttcagcgtg tccggcgagg gcgaggtgag tctatgggac ccttgatgtt t                51


<210>  45
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  optional phosphorothioate internucleoside linkage

<400>  45
aaacatcaag ggtcccatag actcacctcg ccctcgccgg acacgctgaa c                51


<210>  46
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (67)..(68)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (68)..(69)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (69)..(70)
<223>  optional phosphorothioate internucleoside linkage

<400>  46
cttgccccac agggcagtaa cggcagattt ttcttccggc gttaaatgca ccatggtgtc       60

tgtttgaggt                                                              70


<210>  47
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  optional phosphorothioate internucleoside linkage

<400>  47
acagacacca tggtgcacct gactcctgag gagaagtctg ccgttactgc c                51


<210>  48
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (63)..(64)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (64)..(65)
<223>  optional phosphorothioate internucleoside linkage

<400>  48
ttgccccaca gggcagtaac ggcagacttc tcctcaggag tcaggtgcac catggtgtct       60

gtttg                                                                   65


<210>  49
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (60)..(61)
<223>  optional phosphorothioate internucleoside linkage

<400>  49
ttctgtatct atattcatca taggaaacac caaagataat gttctcctta atggtgccag       60

g                                                                       61


<210>  50
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (60)..(61)
<223>  optional phosphorothioate internucleoside linkage

<400>  50
tcttgggatt caataacctt gcagacagtg gaggaaggcc tttggcgtga taccacaggt       60

g                                                                       61


<210>  51
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (60)..(61)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (61)..(62)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  optional phosphorothioate internucleoside linkage

<400>  51
tccaagtttg cagagaaaga taatatagtc cttggagaag gaggaatcac cctgagtgga       60

ggt                                                                     63


<210>  52
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (61)..(62)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (63)..(64)
<223>  optional phosphorothioate internucleoside linkage

<400>  52
aggacggtcc cggcctgcga cacttccgcc cataattgtt cttcatctgc ggggcggggg       60

gggg                                                                    64


<210>  53
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (64)..(65)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (65)..(66)
<223>  optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (66)..(67)
<223>  optional phosphorothioate internucleoside linkage

<400>  53
gggacggcgc ccacataggc caaattcaat tgctgatccc agcttaagac gtactggtca       60

gcctggc                                                                 67


