                               SEQUENCE LISTING

<110> HCW BIOLOGICS, INC.
 
<120> SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF

<130> 47039-0008WO1

<140>
<141>

<150> 62/881,039
<151> 2019-07-31

<150> 62/817,244
<151> 2019-03-12

<150> 62/817,241
<151> 2019-03-12

<150> 62/816,683
<151> 2019-03-11

<150> 62/749,506
<151> 2018-10-23

<150> 62/746,832
<151> 2018-10-17

<150> 62/725,038
<151> 2018-08-30

<160> 117   

<170> PatentIn version 3.5

<210> 1
<211> 696
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      alphaCD3scFv/TF/alphaCD28scFv sequence"

<400> 1
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys 
145                 150                 155                 160 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
                165                 170                 175     


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
            180                 185                 190         


Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
    210                 215                 220                 


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys 
                245                 250                 255     


Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn 
            260                 265                 270         


Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser 
        275                 280                 285             


Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile 
    290                 295                 300                 


Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro 
305                 310                 315                 320 


Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu 
                325                 330                 335     


Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro 
            340                 345                 350         


Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val 
        355                 360                 365             


Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu 
    370                 375                 380                 


Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys 
385                 390                 395                 400 


Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe 
                405                 410                 415     


Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala 
            420                 425                 430         


Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val 
        435                 440                 445             


Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Val Gln Leu Gln 
    450                 455                 460                 


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
465                 470                 475                 480 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Ile Gln Trp Val 
                485                 490                 495     


Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Ser Ile Asn Pro 
            500                 505                 510         


Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr 
        515                 520                 525             


Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met Glu Phe Ser Ser 
    530                 535                 540                 


Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala Arg Trp Gly Asp 
545                 550                 555                 560 


Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu 
            580                 585                 590         


Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu Arg Val 
        595                 600                 605             


Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Phe His 
    610                 615                 620                 


Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Cys Ile Tyr Ser 
625                 630                 635                 640 


Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly 
                645                 650                 655     


Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala 
            660                 665                 670         


Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro Thr Phe Gly Gly 
        675                 680                 685             


Gly Thr Lys Leu Glu Thr Lys Arg 
    690                 695     


<210> 2
<211> 2088
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="alphaCD3scFv/TF/alphaCD28scFv"

<400> 2
cagatcgtgc tgacccaaag ccccgccatc atgagcgcta gccccggtga gaaggtgacc       60

atgacatgct ccgcttccag ctccgtgtcc tacatgaact ggtatcagca gaaaagcgga      120

accagcccca aaaggtggat ctacgacacc agcaagctgg cctccggagt gcccgctcat      180

ttccggggct ctggatccgg caccagctac tctttaacca tttccggcat ggaagctgaa      240

gacgctgcca cctactattg ccagcaatgg agcagcaacc ccttcacatt cggatctggc      300

accaagctcg aaatcaatcg tggaggaggt ggcagcggcg gcggtggatc cggcggagga      360

ggaagccaag ttcaactcca gcagagcggc gctgaactgg cccggcccgg cgcctccgtc      420

aagatgagct gcaaggcttc cggctataca tttactcgtt acacaatgca ttgggtcaag      480

cagaggcccg gtcaaggttt agagtggatc ggatatatca acccttcccg gggctacacc      540

aactataacc aaaagttcaa ggataaagcc actttaacca ctgacaagag ctcctccacc      600

gcctacatgc agctgtcctc tttaaccagc gaggactccg ctgtttacta ctgcgctagg      660

tattacgacg accactactg tttagactat tggggacaag gtaccacttt aaccgtcagc      720

agctccggca ccaccaatac cgtggccgct tataacctca catggaagag caccaacttc      780

aagacaattc tggaatggga acccaagccc gtcaatcaag tttacaccgt gcagatctcc      840

accaaatccg gagactggaa gagcaagtgc ttctacacaa cagacaccga gtgtgattta      900

accgacgaaa tcgtcaagga cgtcaagcaa acctatctgg ctcgggtctt ttcctacccc      960

gctggcaatg tcgagtccac cggctccgct ggcgagcctc tctacgagaa ttcccccgaa     1020

ttcacccctt atttagagac caatttaggc cagcctacca tccagagctt cgagcaagtt     1080

ggcaccaagg tgaacgtcac cgtcgaggat gaaaggactt tagtgcggcg gaataacaca     1140

tttttatccc tccgggatgt gttcggcaaa gacctcatct acacactgta ctattggaag     1200

tccagctcct ccggcaaaaa gaccgctaag accaacacca acgagttttt aattgacgtg     1260

gacaaaggcg agaactactg cttcagcgtg caagccgtga tcccttctcg taccgtcaac     1320

cggaagagca cagattcccc cgttgagtgc atgggccaag aaaagggcga gttccgggag     1380

gtccagctgc agcagagcgg acccgaactc gtgaaacccg gtgcttccgt gaaaatgtct     1440

tgtaaggcca gcggatacac cttcacctcc tatgtgatcc agtgggtcaa acagaagccc     1500

ggacaaggtc tcgagtggat cggcagcatc aacccttaca acgactatac caaatacaac     1560

gagaagttta agggaaaggc tactttaacc tccgacaaaa gctccatcac agcctacatg     1620

gagttcagct ctttaacatc cgaggacagc gctctgtact attgcgcccg gtggggcgac     1680

ggcaattact ggggacgggg cacaacactg accgtgagca gcggaggcgg aggctccggc     1740

ggaggcggat ctggcggtgg cggctccgac atcgagatga cccagtcccc cgctatcatg     1800

tccgcctctt taggcgagcg ggtcacaatg acttgtacag cctcctccag cgtctcctcc     1860

tcctacttcc attggtacca acagaaaccc ggaagctccc ctaaactgtg catctacagc     1920

accagcaatc tcgccagcgg cgtgccccct aggttttccg gaagcggaag caccagctac     1980

tctttaacca tctcctccat ggaggctgag gatgccgcca cctacttttg tcaccagtac     2040

caccggtccc ccaccttcgg aggcggcacc aaactggaga caaagagg                  2088


<210> 3
<211> 714
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="alphaCD3scFv/TF/alphaCD28scFv"

<400> 3
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser 
            20                  25                  30          


Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
        35                  40                  45              


Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp 
    50                  55                  60                  


Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu 
                85                  90                  95      


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
            100                 105                 110         


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met 
145                 150                 155                 160 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp 
                165                 170                 175     


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
            180                 185                 190         


Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
        195                 200                 205             


Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
    210                 215                 220                 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr 
225                 230                 235                 240 


Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
                245                 250                 255     


Val Ser Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr 
            260                 265                 270         


Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro 
        275                 280                 285             


Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp 
    290                 295                 300                 


Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp 
305                 310                 315                 320 


Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser 
                325                 330                 335     


Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu 
            340                 345                 350         


Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly 
        355                 360                 365             


Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val 
    370                 375                 380                 


Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu 
385                 390                 395                 400 


Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr 
                405                 410                 415     


Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn 
            420                 425                 430         


Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val 
        435                 440                 445             


Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser 
    450                 455                 460                 


Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Val Gln 
465                 470                 475                 480 


Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
                485                 490                 495     


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Ile Gln 
            500                 505                 510         


Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Ser Ile 
        515                 520                 525             


Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys 
    530                 535                 540                 


Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met Glu Phe 
545                 550                 555                 560 


Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala Arg Trp 
                565                 570                 575     


Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val Ser Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        595                 600                 605             


Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu 
    610                 615                 620                 


Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr 
625                 630                 635                 640 


Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Cys Ile 
                645                 650                 655     


Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly 
            660                 665                 670         


Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
        675                 680                 685             


Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro Thr Phe 
    690                 695                 700                 


Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg 
705                 710                 


<210> 4
<211> 2142
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="alphaCD3scFv/TF/alphaCD28scFv"

<400> 4
atgaagtggg tgaccttcat cagcttatta tttttattca gctccgccta ttcccagatc       60

gtgctgaccc aaagccccgc catcatgagc gctagccccg gtgagaaggt gaccatgaca      120

tgctccgctt ccagctccgt gtcctacatg aactggtatc agcagaaaag cggaaccagc      180

cccaaaaggt ggatctacga caccagcaag ctggcctccg gagtgcccgc tcatttccgg      240

ggctctggat ccggcaccag ctactcttta accatttccg gcatggaagc tgaagacgct      300

gccacctact attgccagca atggagcagc aaccccttca cattcggatc tggcaccaag      360

ctcgaaatca atcgtggagg aggtggcagc ggcggcggtg gatccggcgg aggaggaagc      420

caagttcaac tccagcagag cggcgctgaa ctggcccggc ccggcgcctc cgtcaagatg      480

agctgcaagg cttccggcta tacatttact cgttacacaa tgcattgggt caagcagagg      540

cccggtcaag gtttagagtg gatcggatat atcaaccctt cccggggcta caccaactat      600

aaccaaaagt tcaaggataa agccacttta accactgaca agagctcctc caccgcctac      660

atgcagctgt cctctttaac cagcgaggac tccgctgttt actactgcgc taggtattac      720

gacgaccact actgtttaga ctattgggga caaggtacca ctttaaccgt cagcagctcc      780

ggcaccacca ataccgtggc cgcttataac ctcacatgga agagcaccaa cttcaagaca      840

attctggaat gggaacccaa gcccgtcaat caagtttaca ccgtgcagat ctccaccaaa      900

tccggagact ggaagagcaa gtgcttctac acaacagaca ccgagtgtga tttaaccgac      960

gaaatcgtca aggacgtcaa gcaaacctat ctggctcggg tcttttccta ccccgctggc     1020

aatgtcgagt ccaccggctc cgctggcgag cctctctacg agaattcccc cgaattcacc     1080

ccttatttag agaccaattt aggccagcct accatccaga gcttcgagca agttggcacc     1140

aaggtgaacg tcaccgtcga ggatgaaagg actttagtgc ggcggaataa cacattttta     1200

tccctccggg atgtgttcgg caaagacctc atctacacac tgtactattg gaagtccagc     1260

tcctccggca aaaagaccgc taagaccaac accaacgagt ttttaattga cgtggacaaa     1320

ggcgagaact actgcttcag cgtgcaagcc gtgatccctt ctcgtaccgt caaccggaag     1380

agcacagatt cccccgttga gtgcatgggc caagaaaagg gcgagttccg ggaggtccag     1440

ctgcagcaga gcggacccga actcgtgaaa cccggtgctt ccgtgaaaat gtcttgtaag     1500

gccagcggat acaccttcac ctcctatgtg atccagtggg tcaaacagaa gcccggacaa     1560

ggtctcgagt ggatcggcag catcaaccct tacaacgact ataccaaata caacgagaag     1620

tttaagggaa aggctacttt aacctccgac aaaagctcca tcacagccta catggagttc     1680

agctctttaa catccgagga cagcgctctg tactattgcg cccggtgggg cgacggcaat     1740

tactggggac ggggcacaac actgaccgtg agcagcggag gcggaggctc cggcggaggc     1800

ggatctggcg gtggcggctc cgacatcgag atgacccagt cccccgctat catgtccgcc     1860

tctttaggcg agcgggtcac aatgacttgt acagcctcct ccagcgtctc ctcctcctac     1920

ttccattggt accaacagaa acccggaagc tcccctaaac tgtgcatcta cagcaccagc     1980

aatctcgcca gcggcgtgcc ccctaggttt tccggaagcg gaagcaccag ctactcttta     2040

accatctcct ccatggaggc tgaggatgcc gccacctact tttgtcacca gtaccaccgg     2100

tcccccacct tcggaggcgg caccaaactg gagacaaaga gg                        2142


<210> 5
<211> 696
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="alphaCD28scFv/TF/alphaCD3scFv"

<400> 5
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
            20                  25                  30          


Ile Gln Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu 
    130                 135                 140                 


Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser 
145                 150                 155                 160 


Ser Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu 
                165                 170                 175     


Cys Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
        195                 200                 205             


Ala Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg Ser Gly Thr Thr 
225                 230                 235                 240 


Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys 
                245                 250                 255     


Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val 
            260                 265                 270         


Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr 
        275                 280                 285             


Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys 
    290                 295                 300                 


Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu 
305                 310                 315                 320 


Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe 
                325                 330                 335     


Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe 
            340                 345                 350         


Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr 
        355                 360                 365             


Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly 
    370                 375                 380                 


Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly 
385                 390                 395                 400 


Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp 
                405                 410                 415     


Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg 
            420                 425                 430         


Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln 
        435                 440                 445             


Glu Lys Gly Glu Phe Arg Glu Gln Ile Val Leu Thr Gln Ser Pro Ala 
    450                 455                 460                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
465                 470                 475                 480 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                485                 490                 495     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            500                 505                 510         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        515                 520                 525             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    530                 535                 540                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
545                 550                 555                 560 


Asn Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly 
            580                 585                 590         


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
        595                 600                 605             


Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
    610                 615                 620                 


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys 
625                 630                 635                 640 


Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala 
                645                 650                 655     


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
            660                 665                 670         


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
        675                 680                 685             


Gly Thr Thr Leu Thr Val Ser Ser 
    690                 695     


<210> 6
<211> 2088
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="alphaCD28scFv/TF/alphaCD3scFv"

<400> 6
gtgcagctgc agcagtccgg acccgaactg gtcaagcccg gtgcctccgt gaaaatgtct       60

tgtaaggctt ctggctacac ctttacctcc tacgtcatcc aatgggtgaa gcagaagccc      120

ggtcaaggtc tcgagtggat cggcagcatc aatccctaca acgattacac caagtataac      180

gaaaagttta agggcaaggc cactctgaca agcgacaaga gctccattac cgcctacatg      240

gagttttcct ctttaacttc tgaggactcc gctttatact attgcgctcg ttggggcgat      300

ggcaattatt ggggccgggg aactacttta acagtgagct ccggcggcgg cggaagcgga      360

ggtggaggat ctggcggtgg aggcagcgac atcgagatga cacagtcccc cgctatcatg      420

agcgcctctt taggagaacg tgtgaccatg acttgtacag cttcctccag cgtgagcagc      480

tcctatttcc actggtacca gcagaaaccc ggctcctccc ctaaactgtg tatctactcc      540

acaagcaatt tagctagcgg cgtgcctcct cgttttagcg gctccggcag cacctcttac      600

tctttaacca ttagctctat ggaggccgaa gatgccgcca catacttttg ccatcagtac      660

caccggtccc ctacctttgg cggaggcaca aagctggaga ccaagcggag cggcaccacc      720

aacacagtgg ccgcctacaa tctgacttgg aaatccacca acttcaagac catcctcgag      780

tgggagccca agcccgttaa tcaagtttat accgtgcaga tttccaccaa gagcggcgac      840

tggaaatcca agtgcttcta taccacagac accgagtgcg atctcaccga cgagatcgtc      900

aaagacgtga agcagacata tttagctagg gtgttctcct accccgctgg aaacgtggag      960

agcaccggat ccgctggaga gcctttatac gagaactccc ccgaattcac cccctatctg     1020

gaaaccaatt taggccagcc caccatccag agcttcgaac aagttggcac aaaggtgaac     1080

gtcaccgtcg aagatgagag gactttagtg cggaggaaca atacattttt atccttacgt     1140

gacgtcttcg gcaaggattt aatctacaca ctgtattact ggaagtctag ctcctccggc     1200

aagaagaccg ccaagaccaa taccaacgaa tttttaattg acgtggacaa gggcgagaac     1260

tactgcttct ccgtgcaagc tgtgatcccc tcccggacag tgaaccggaa gtccaccgac     1320

tcccccgtgg agtgcatggg ccaagagaag ggagagtttc gtgagcagat cgtgctgacc     1380

cagtcccccg ctattatgag cgctagcccc ggtgaaaagg tgactatgac atgcagcgcc     1440

agctcttccg tgagctacat gaactggtat cagcagaagt ccggcaccag ccctaaaagg     1500

tggatctacg acaccagcaa gctggccagc ggcgtccccg ctcactttcg gggctccggc     1560

tccggaacaa gctactctct gaccatcagc ggcatggaag ccgaggatgc cgctacctat     1620

tactgtcagc agtggagctc caaccccttc acctttggat ccggcaccaa gctcgagatt     1680

aatcgtggag gcggaggtag cggaggaggc ggatccggcg gtggaggtag ccaagttcag     1740

ctccagcaaa gcggcgccga actcgctcgg cccggcgctt ccgtgaagat gtcttgtaag     1800

gcctccggct ataccttcac ccggtacaca atgcactggg tcaagcaacg gcccggtcaa     1860

ggtttagagt ggattggcta tatcaacccc tcccggggct ataccaacta caaccagaag     1920

ttcaaggaca aagccaccct caccaccgac aagtccagca gcaccgctta catgcagctg     1980

agctctttaa catccgagga ttccgccgtg tactactgcg ctcggtacta cgacgatcat     2040

tactgcctcg attactgggg ccaaggtacc accttaacag tctcctcc                  2088


<210> 7
<211> 714
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="alphaCD28scFv/TF/alphaCD3scFv"

<400> 7
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
            20                  25                  30          


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
        35                  40                  45              


Tyr Val Ile Gln Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp 
    50                  55                  60                  


Ile Gly Ser Ile Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys 
65                  70                  75                  80  


Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala 
                85                  90                  95      


Tyr Met Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Trp Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu 
        115                 120                 125             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala 
145                 150                 155                 160 


Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Ser Ser Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
            180                 185                 190         


Lys Leu Cys Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
    210                 215                 220                 


Met Glu Ala Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg 
225                 230                 235                 240 


Ser Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg Ser Gly 
                245                 250                 255     


Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn 
            260                 265                 270         


Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr 
        275                 280                 285             


Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe 
    290                 295                 300                 


Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp 
305                 310                 315                 320 


Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn 
                325                 330                 335     


Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro 
            340                 345                 350         


Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln 
        355                 360                 365             


Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu 
    370                 375                 380                 


Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val 
385                 390                 395                 400 


Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser 
                405                 410                 415     


Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp 
            420                 425                 430         


Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro 
        435                 440                 445             


Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met 
    450                 455                 460                 


Gly Gln Glu Lys Gly Glu Phe Arg Glu Gln Ile Val Leu Thr Gln Ser 
465                 470                 475                 480 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                485                 490                 495     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
            500                 505                 510         


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
        515                 520                 525             


Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    530                 535                 540                 


Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
545                 550                 555                 560 


Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
                565                 570                 575     


Glu Ile Asn Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
        595                 600                 605             


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    610                 615                 620                 


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
625                 630                 635                 640 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
                645                 650                 655     


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
            660                 665                 670         


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
        675                 680                 685             


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
    690                 695                 700                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
705                 710                 


<210> 8
<211> 2142
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="alphaCD28scFv/TF/alphaCD3scFv"

<400> 8
atgaaatggg tcaccttcat ctctttactg tttttattta gcagcgccta cagcgtgcag       60

ctgcagcagt ccggacccga actggtcaag cccggtgcct ccgtgaaaat gtcttgtaag      120

gcttctggct acacctttac ctcctacgtc atccaatggg tgaagcagaa gcccggtcaa      180

ggtctcgagt ggatcggcag catcaatccc tacaacgatt acaccaagta taacgaaaag      240

tttaagggca aggccactct gacaagcgac aagagctcca ttaccgccta catggagttt      300

tcctctttaa cttctgagga ctccgcttta tactattgcg ctcgttgggg cgatggcaat      360

tattggggcc ggggaactac tttaacagtg agctccggcg gcggcggaag cggaggtgga      420

ggatctggcg gtggaggcag cgacatcgag atgacacagt cccccgctat catgagcgcc      480

tctttaggag aacgtgtgac catgacttgt acagcttcct ccagcgtgag cagctcctat      540

ttccactggt accagcagaa acccggctcc tcccctaaac tgtgtatcta ctccacaagc      600

aatttagcta gcggcgtgcc tcctcgtttt agcggctccg gcagcacctc ttactcttta      660

accattagct ctatggaggc cgaagatgcc gccacatact tttgccatca gtaccaccgg      720

tcccctacct ttggcggagg cacaaagctg gagaccaagc ggagcggcac caccaacaca      780

gtggccgcct acaatctgac ttggaaatcc accaacttca agaccatcct cgagtgggag      840

cccaagcccg ttaatcaagt ttataccgtg cagatttcca ccaagagcgg cgactggaaa      900

tccaagtgct tctataccac agacaccgag tgcgatctca ccgacgagat cgtcaaagac      960

gtgaagcaga catatttagc tagggtgttc tcctaccccg ctggaaacgt ggagagcacc     1020

ggatccgctg gagagccttt atacgagaac tcccccgaat tcacccccta tctggaaacc     1080

aatttaggcc agcccaccat ccagagcttc gaacaagttg gcacaaaggt gaacgtcacc     1140

gtcgaagatg agaggacttt agtgcggagg aacaatacat ttttatcctt acgtgacgtc     1200

ttcggcaagg atttaatcta cacactgtat tactggaagt ctagctcctc cggcaagaag     1260

accgccaaga ccaataccaa cgaattttta attgacgtgg acaagggcga gaactactgc     1320

ttctccgtgc aagctgtgat cccctcccgg acagtgaacc ggaagtccac cgactccccc     1380

gtggagtgca tgggccaaga gaagggagag tttcgtgagc agatcgtgct gacccagtcc     1440

cccgctatta tgagcgctag ccccggtgaa aaggtgacta tgacatgcag cgccagctct     1500

tccgtgagct acatgaactg gtatcagcag aagtccggca ccagccctaa aaggtggatc     1560

tacgacacca gcaagctggc cagcggcgtc cccgctcact ttcggggctc cggctccgga     1620

acaagctact ctctgaccat cagcggcatg gaagccgagg atgccgctac ctattactgt     1680

cagcagtgga gctccaaccc cttcaccttt ggatccggca ccaagctcga gattaatcgt     1740

ggaggcggag gtagcggagg aggcggatcc ggcggtggag gtagccaagt tcagctccag     1800

caaagcggcg ccgaactcgc tcggcccggc gcttccgtga agatgtcttg taaggcctcc     1860

ggctatacct tcacccggta cacaatgcac tgggtcaagc aacggcccgg tcaaggttta     1920

gagtggattg gctatatcaa cccctcccgg ggctatacca actacaacca gaagttcaag     1980

gacaaagcca ccctcaccac cgacaagtcc agcagcaccg cttacatgca gctgagctct     2040

ttaacatccg aggattccgc cgtgtactac tgcgctcggt actacgacga tcattactgc     2100

ctcgattact ggggccaagg taccacctta acagtctcct cc                        2142


<210> 9
<211> 219
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Soluble Human Tissue Factor Domain"

<400> 9
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


<210> 10
<211> 657
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Soluble Human Tissue Factor Domain"

<400> 10
agcggcacaa ccaacacagt cgctgcctat aacctcactt ggaagagcac caacttcaaa       60

accatcctcg aatgggaacc caaacccgtt aaccaagttt acaccgtgca gatcagcacc      120

aagtccggcg actggaagtc caaatgtttc tataccaccg acaccgagtg cgatctcacc      180

gatgagatcg tgaaagatgt gaaacagacc tacctcgccc gggtgtttag ctaccccgcc      240

ggcaatgtgg agagcactgg ttccgctggc gagcctttat acgagaacag ccccgaattt      300

accccttacc tcgagaccaa tttaggacag cccaccatcc aaagctttga gcaagttggc      360

acaaaggtga atgtgacagt ggaggacgag cggactttag tgcggcggaa caacaccttt      420

ctcagcctcc gggatgtgtt cggcaaagat ttaatctaca cactgtatta ctggaagtcc      480

tcttcctccg gcaagaagac agctaaaacc aacacaaacg agtttttaat cgacgtggat      540

aaaggcgaaa actactgttt cagcgtgcaa gctgtgatcc cctcccggac cgtgaatagg      600

aaaagcaccg atagccccgt tgagtgcatg ggccaagaaa agggcgagtt ccgggag         657


<210> 11
<211> 223
<212> PRT
<213> Mus musculus

<220>
<221> source
<223> /note="Soluble Mouse Tissue Factor Domain"

<400> 11
Ala Gly Ile Pro Glu Lys Ala Phe Asn Leu Thr Trp Ile Ser Thr Asp 
1               5                   10                  15      


Phe Lys Thr Ile Leu Glu Trp Gln Pro Lys Pro Thr Asn Tyr Thr Tyr 
            20                  25                  30          


Thr Val Gln Ile Ser Asp Arg Ser Arg Asn Trp Lys Asn Lys Cys Phe 
        35                  40                  45              


Ser Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp 
    50                  55                  60                  


Val Thr Trp Ala Tyr Glu Ala Lys Val Leu Ser Val Pro Arg Arg Asn 
65                  70                  75                  80  


Ser Val His Gly Asp Gly Asp Gln Leu Val Ile His Gly Glu Glu Pro 
                85                  90                  95      


Pro Phe Thr Asn Ala Pro Lys Phe Leu Pro Tyr Arg Asp Thr Asn Leu 
            100                 105                 110         


Gly Gln Pro Val Ile Gln Gln Phe Glu Gln Asp Gly Arg Lys Leu Asn 
        115                 120                 125             


Val Val Val Lys Asp Ser Leu Thr Leu Val Arg Lys Asn Gly Thr Phe 
    130                 135                 140                 


Leu Thr Leu Arg Gln Val Phe Gly Lys Asp Leu Gly Tyr Ile Ile Thr 
145                 150                 155                 160 


Tyr Arg Lys Gly Ser Ser Thr Gly Lys Lys Thr Asn Ile Thr Asn Thr 
                165                 170                 175     


Asn Glu Phe Ser Ile Asp Val Glu Glu Gly Val Ser Tyr Cys Phe Phe 
            180                 185                 190         


Val Gln Ala Met Ile Phe Ser Arg Lys Thr Asn Gln Asn Ser Pro Gly 
        195                 200                 205             


Ser Ser Thr Val Cys Thr Glu Gln Trp Lys Ser Phe Leu Gly Glu 
    210                 215                 220             


<210> 12
<211> 224
<212> PRT
<213> Rattus rattus

<220>
<221> source
<223> /note="Soluble Rat Tissue Factor Domain"

<400> 12
Ala Gly Thr Pro Pro Gly Lys Ala Phe Asn Leu Thr Trp Ile Ser Thr 
1               5                   10                  15      


Asp Phe Lys Thr Ile Leu Glu Trp Gln Pro Lys Pro Thr Asn Tyr Thr 
            20                  25                  30          


Tyr Thr Val Gln Ile Ser Asp Arg Ser Arg Asn Trp Lys Tyr Lys Cys 
        35                  40                  45              


Thr Gly Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
    50                  55                  60                  


Asp Val Asn Trp Thr Tyr Glu Ala Arg Val Leu Ser Val Pro Trp Arg 
65                  70                  75                  80  


Asn Ser Thr His Gly Lys Glu Thr Leu Phe Gly Thr His Gly Glu Glu 
                85                  90                  95      


Pro Pro Phe Thr Asn Ala Arg Lys Phe Leu Pro Tyr Arg Asp Thr Lys 
            100                 105                 110         


Ile Gly Gln Pro Val Ile Gln Lys Tyr Glu Gln Gly Gly Thr Lys Leu 
        115                 120                 125             


Lys Val Thr Val Lys Asp Ser Phe Thr Leu Val Arg Lys Asn Gly Thr 
    130                 135                 140                 


Phe Leu Thr Leu Arg Gln Val Phe Gly Asn Asp Leu Gly Tyr Ile Leu 
145                 150                 155                 160 


Thr Tyr Arg Lys Asp Ser Ser Thr Gly Arg Lys Thr Asn Thr Thr His 
                165                 170                 175     


Thr Asn Glu Phe Leu Ile Asp Val Glu Lys Gly Val Ser Tyr Cys Phe 
            180                 185                 190         


Phe Ala Gln Ala Val Ile Phe Ser Arg Lys Thr Asn His Lys Ser Pro 
        195                 200                 205             


Glu Ser Ile Thr Lys Cys Thr Glu Gln Trp Lys Ser Val Leu Gly Glu 
    210                 215                 220                 


<210> 13
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 13
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 14
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 14
ggcggtggag gatccggagg aggtggctcc ggcggcggag gatct                       45


<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 15
Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210> 16
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD3 scFv heavy chain variable domain sequence"

<400> 16
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210> 17
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD3 scFv light chain variable domain sequence"

<400> 17
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg 
            100                 105         


<210> 18
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD3 scFv heavy chain variable domain sequence"

<400> 18
caagttcagc tccagcaaag cggcgccgaa ctcgctcggc ccggcgcttc cgtgaagatg       60

tcttgtaagg cctccggcta taccttcacc cggtacacaa tgcactgggt caagcaacgg      120

cccggtcaag gtttagagtg gattggctat atcaacccct cccggggcta taccaactac      180

aaccagaagt tcaaggacaa agccaccctc accaccgaca agtccagcag caccgcttac      240

atgcagctga gctctttaac atccgaggat tccgccgtgt actactgcgc tcggtactac      300

gacgatcatt actgcctcga ttactggggc caaggtacca ccttaacagt ctcctcc         357


<210> 19
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD3 scFv light chain variable domain sequence"

<400> 19
cagatcgtgc tgacccagtc ccccgctatt atgagcgcta gccccggtga aaaggtgact       60

atgacatgca gcgccagctc ttccgtgagc tacatgaact ggtatcagca gaagtccggc      120

accagcccta aaaggtggat ctacgacacc agcaagctgg ccagcggcgt ccccgctcac      180

tttcggggct ccggctccgg aacaagctac tctctgacca tcagcggcat ggaagccgag      240

gatgccgcta cctattactg tcagcagtgg agctccaacc ccttcacctt tggatccggc      300

accaagctcg agattaatcg t                                                321


<210> 20
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD3 scFv sequence"

<400> 20
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys 
145                 150                 155                 160 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
                165                 170                 175     


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
            180                 185                 190         


Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
    210                 215                 220                 


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210> 21
<211> 723
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD3 scFv sequence"

<400> 21
cagatcgtgc tgacccagtc ccccgctatt atgagcgcta gccccggtga aaaggtgact       60

atgacatgca gcgccagctc ttccgtgagc tacatgaact ggtatcagca gaagtccggc      120

accagcccta aaaggtggat ctacgacacc agcaagctgg ccagcggcgt ccccgctcac      180

tttcggggct ccggctccgg aacaagctac tctctgacca tcagcggcat ggaagccgag      240

gatgccgcta cctattactg tcagcagtgg agctccaacc ccttcacctt tggatccggc      300

accaagctcg agattaatcg tggaggcgga ggtagcggag gaggcggatc cggcggtgga      360

ggtagccaag ttcagctcca gcaaagcggc gccgaactcg ctcggcccgg cgcttccgtg      420

aagatgtctt gtaaggcctc cggctatacc ttcacccggt acacaatgca ctgggtcaag      480

caacggcccg gtcaaggttt agagtggatt ggctatatca acccctcccg gggctatacc      540

aactacaacc agaagttcaa ggacaaagcc accctcacca ccgacaagtc cagcagcacc      600

gcttacatgc agctgagctc tttaacatcc gaggattccg ccgtgtacta ctgcgctcgg      660

tactacgacg atcattactg cctcgattac tggggccaag gtaccacctt aacagtctcc      720

tcc                                                                    723


<210> 22
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD28 scFv heavy chain variable domain sequence"

<400> 22
Asp Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Cys 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg 
            100                 105         


<210> 23
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD28 scFv light chain variable domain sequence"

<400> 23
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
            20                  25                  30          


Ile Gln Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210> 24
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD28 scFv heavy chain variable domain sequence"

<400> 24
gacatcgaga tgacacagtc ccccgctatc atgagcgcct ctttaggaga acgtgtgacc       60

atgacttgta cagcttcctc cagcgtgagc agctcctatt tccactggta ccagcagaaa      120

cccggctcct cccctaaact gtgtatctac tccacaagca atttagctag cggcgtgcct      180

cctcgtttta gcggctccgg cagcacctct tactctttaa ccattagctc tatggaggcc      240

gaagatgccg ccacatactt ttgccatcag taccaccggt cccctacctt tggcggaggc      300

acaaagctgg agaccaagcg g                                                321


<210> 25
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD28 scFv light chain variable domain sequence"

<400> 25
gtgcagctgc agcagtccgg acccgaactg gtcaagcccg gtgcctccgt gaaaatgtct       60

tgtaaggctt ctggctacac ctttacctcc tacgtcatcc aatgggtgaa gcagaagccc      120

ggtcaaggtc tcgagtggat cggcagcatc aatccctaca acgattacac caagtataac      180

gaaaagttta agggcaaggc cactctgaca agcgacaaga gctccattac cgcctacatg      240

gagttttcct ctttaacttc tgaggactcc gctttatact attgcgctcg ttggggcgat      300

ggcaattatt ggggccgggg aactacttta acagtgagct cc                         342


<210> 26
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD28 scFv sequence"

<400> 26
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
            20                  25                  30          


Ile Gln Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu 
    130                 135                 140                 


Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser 
145                 150                 155                 160 


Ser Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu 
                165                 170                 175     


Cys Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
        195                 200                 205             


Ala Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg 
225                 230                 235     


<210> 27
<211> 708
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Anti-CD28 scFv sequence"

<400> 27
gtgcagctgc agcagtccgg acccgaactg gtcaagcccg gtgcctccgt gaaaatgtct       60

tgtaaggctt ctggctacac ctttacctcc tacgtcatcc aatgggtgaa gcagaagccc      120

ggtcaaggtc tcgagtggat cggcagcatc aatccctaca acgattacac caagtataac      180

gaaaagttta agggcaaggc cactctgaca agcgacaaga gctccattac cgcctacatg      240

gagttttcct ctttaacttc tgaggactcc gctttatact attgcgctcg ttggggcgat      300

ggcaattatt ggggccgggg aactacttta acagtgagct ccggcggcgg cggaagcgga      360

ggtggaggat ctggcggtgg aggcagcgac atcgagatga cacagtcccc cgctatcatg      420

agcgcctctt taggagaacg tgtgaccatg acttgtacag cttcctccag cgtgagcagc      480

tcctatttcc actggtacca gcagaaaccc ggctcctccc ctaaactgtg tatctactcc      540

acaagcaatt tagctagcgg cgtgcctcct cgttttagcg gctccggcag cacctcttac      600

tctttaacca ttagctctat ggaggccgaa gatgccgcca catacttttg ccatcagtac      660

caccggtccc ctacctttgg cggaggcaca aagctggaga ccaagcgg                   708


<210> 28
<211> 133
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-2"

<400> 28
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210> 29
<211> 133
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-3"

<400> 29
Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp Val Asn Cys 
1               5                   10                  15      


Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu 
            20                  25                  30          


Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu 
        35                  40                  45              


Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala 
    50                  55                  60                  


Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn 
65                  70                  75                  80  


Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro 
                85                  90                  95      


Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr 
            100                 105                 110         


Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln Thr Thr Leu 
        115                 120                 125             


Ser Leu Ala Ile Phe 
    130             


<210> 30
<211> 152
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-7"

<400> 30
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210> 31
<211> 79
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-8"

<400> 31
Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys 
1               5                   10                  15      


Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu 
            20                  25                  30          


Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val 
        35                  40                  45              


Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp 
    50                  55                  60                  


Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser 
65                  70                  75                  


<210> 32
<211> 160
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-10"

<400> 32
Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210> 33
<211> 306
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-12beta (p40)"

<400> 33
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210> 34
<211> 918
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-12beta (p40)"

<400> 34
atttgggaac tgaagaagga cgtctacgtg gtcgaactgg actggtatcc cgatgctccc       60

ggcgaaatgg tggtgctcac ttgtgacacc cccgaagaag acggcatcac ttggaccctc      120

gatcagagca gcgaggtgct gggctccgga aagaccctca caatccaagt taaggagttc      180

ggagacgctg gccaatacac atgccacaag ggaggcgagg tgctcagcca ttccttatta      240

ttattacaca agaaggaaga cggaatctgg tccaccgaca ttttaaaaga tcagaaggag      300

cccaagaata agaccttttt aaggtgtgag gccaaaaact acagcggtcg tttcacttgt      360

tggtggctga ccaccatttc caccgattta accttctccg tgaaaagcag ccggggaagc      420

tccgaccctc aaggtgtgac atgtggagcc gctaccctca gcgctgagag ggttcgtggc      480

gataacaagg aatacgagta cagcgtggag tgccaagaag atagcgcttg tcccgctgcc      540

gaagaatctt tacccattga ggtgatggtg gacgccgtgc acaaactcaa gtacgagaac      600

tacacctcct ccttctttat ccgggacatc attaagcccg atcctcctaa gaatttacag      660

ctgaagcctc tcaaaaatag ccggcaagtt gaggtctctt gggaatatcc cgacacttgg      720

agcacacccc acagctactt ctctttaacc ttttgtgtgc aagttcaagg taaaagcaag      780

cgggagaaga aagaccgggt gtttaccgac aaaaccagcg ccaccgtcat ctgtcggaag      840

aacgcctcca tcagcgtgag ggctcaagat cgttattact ccagcagctg gtccgagtgg      900

gccagcgtgc cttgttcc                                                    918


<210> 35
<211> 197
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-12alpha (p35)"

<400> 35
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 36
<211> 591
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-12alpha (p35)"

<400> 36
cgtaacctcc ccgtggctac ccccgatccc ggaatgttcc cttgtttaca ccacagccag       60

aatttactga gggccgtgag caacatgctg cagaaagcta ggcagacttt agaattttac      120

ccttgcacca gcgaggagat cgaccatgaa gatatcacca aggacaagac atccaccgtg      180

gaggcttgtt tacctctgga gctgacaaag aacgagtctt gtctcaactc tcgtgaaacc      240

agcttcatca caaatggctc ttgtttagct tcccggaaga cctcctttat gatggcttta      300

tgcctcagct ccatctacga ggatttaaag atgtaccaag tggagttcaa gaccatgaac      360

gccaagctgc tcatggaccc taaacggcag atctttttag accagaacat gctggctgtg      420

attgatgagc tgatgcaagc tttaaacttc aactccgaga ccgtccctca gaagtcctcc      480

ctcgaggagc ccgattttta caagacaaag atcaaactgt gcattttact ccacgccttt      540

aggatccggg ccgtgaccat tgaccgggtc atgagctatt taaacgccag c               591


<210> 37
<211> 518
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-12"

<400> 37
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser 
        515             


<210> 38
<211> 1554
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-12"

<400> 38
atttgggaac tgaagaagga cgtctacgtg gtcgaactgg actggtatcc cgatgctccc       60

ggcgaaatgg tggtgctcac ttgtgacacc cccgaagaag acggcatcac ttggaccctc      120

gatcagagca gcgaggtgct gggctccgga aagaccctca caatccaagt taaggagttc      180

ggagacgctg gccaatacac atgccacaag ggaggcgagg tgctcagcca ttccttatta      240

ttattacaca agaaggaaga cggaatctgg tccaccgaca ttttaaaaga tcagaaggag      300

cccaagaata agaccttttt aaggtgtgag gccaaaaact acagcggtcg tttcacttgt      360

tggtggctga ccaccatttc caccgattta accttctccg tgaaaagcag ccggggaagc      420

tccgaccctc aaggtgtgac atgtggagcc gctaccctca gcgctgagag ggttcgtggc      480

gataacaagg aatacgagta cagcgtggag tgccaagaag atagcgcttg tcccgctgcc      540

gaagaatctt tacccattga ggtgatggtg gacgccgtgc acaaactcaa gtacgagaac      600

tacacctcct ccttctttat ccgggacatc attaagcccg atcctcctaa gaatttacag      660

ctgaagcctc tcaaaaatag ccggcaagtt gaggtctctt gggaatatcc cgacacttgg      720

agcacacccc acagctactt ctctttaacc ttttgtgtgc aagttcaagg taaaagcaag      780

cgggagaaga aagaccgggt gtttaccgac aaaaccagcg ccaccgtcat ctgtcggaag      840

aacgcctcca tcagcgtgag ggctcaagat cgttattact ccagcagctg gtccgagtgg      900

gccagcgtgc cttgttccgg cggtggagga tccggaggag gtggctccgg cggcggagga      960

tctcgtaacc tccccgtggc tacccccgat cccggaatgt tcccttgttt acaccacagc     1020

cagaatttac tgagggccgt gagcaacatg ctgcagaaag ctaggcagac tttagaattt     1080

tacccttgca ccagcgagga gatcgaccat gaagatatca ccaaggacaa gacatccacc     1140

gtggaggctt gtttacctct ggagctgaca aagaacgagt cttgtctcaa ctctcgtgaa     1200

accagcttca tcacaaatgg ctcttgttta gcttcccgga agacctcctt tatgatggct     1260

ttatgcctca gctccatcta cgaggattta aagatgtacc aagtggagtt caagaccatg     1320

aacgccaagc tgctcatgga ccctaaacgg cagatctttt tagaccagaa catgctggct     1380

gtgattgatg agctgatgca agctttaaac ttcaactccg agaccgtccc tcagaagtcc     1440

tccctcgagg agcccgattt ttacaagaca aagatcaaac tgtgcatttt actccacgcc     1500

tttaggatcc gggccgtgac cattgaccgg gtcatgagct atttaaacgc cagc           1554


<210> 39
<211> 114
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-15"

<400> 39
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 40
<211> 132
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-17"

<400> 40
Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210> 41
<211> 157
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-18"

<400> 41
Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
145                 150                 155         


<210> 42
<211> 471
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-18"

<400> 42
tacttcggca aactggaatc caagctgagc gtgatccgga atttaaacga ccaagttctg       60

tttatcgatc aaggtaaccg gcctctgttc gaggacatga ccgactccga ttgccgggac      120

aatgcccccc ggaccatctt cattatctcc atgtacaagg acagccagcc ccggggcatg      180

gctgtgacaa ttagcgtgaa gtgtgagaaa atcagcactt tatcttgtga gaacaagatc      240

atctccttta aggaaatgaa cccccccgat aacatcaagg acaccaagtc cgatatcatc      300

ttcttccagc ggtccgtgcc cggtcacgat aacaagatgc agttcgaatc ctcctcctac      360

gagggctact ttttagcttg tgaaaaggag agggatttat tcaagctgat cctcaagaag      420

gaggacgagc tgggcgatcg ttccatcatg ttcaccgtcc aaaacgagga t               471


<210> 43
<211> 133
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-21"

<400> 43
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser 
    130             


<210> 44
<211> 399
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble IL-21"

<400> 44
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcc                             399


<210> 45
<211> 352
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble PDGF-D"

<400> 45
Arg Asp Thr Ser Ala Thr Pro Gln Ser Ala Ser Ile Lys Ala Leu Arg 
1               5                   10                  15      


Asn Ala Asn Leu Arg Arg Asp Glu Ser Asn His Leu Thr Asp Leu Tyr 
            20                  25                  30          


Arg Arg Asp Glu Thr Ile Gln Val Lys Gly Asn Gly Tyr Val Gln Ser 
        35                  40                  45              


Pro Arg Phe Pro Asn Ser Tyr Pro Arg Asn Leu Leu Leu Thr Trp Arg 
    50                  55                  60                  


Leu His Ser Gln Glu Asn Thr Arg Ile Gln Leu Val Phe Asp Asn Gln 
65                  70                  75                  80  


Phe Gly Leu Glu Glu Ala Glu Asn Asp Ile Cys Arg Tyr Asp Phe Val 
                85                  90                  95      


Glu Val Glu Asp Ile Ser Glu Thr Ser Thr Ile Ile Arg Gly Arg Trp 
            100                 105                 110         


Cys Gly His Lys Glu Val Pro Pro Arg Ile Lys Ser Arg Thr Asn Gln 
        115                 120                 125             


Ile Lys Ile Thr Phe Lys Ser Asp Asp Tyr Phe Val Ala Lys Pro Gly 
    130                 135                 140                 


Phe Lys Ile Tyr Tyr Ser Leu Leu Glu Asp Phe Gln Pro Ala Ala Ala 
145                 150                 155                 160 


Ser Glu Thr Asn Trp Glu Ser Val Thr Ser Ser Ile Ser Gly Val Ser 
                165                 170                 175     


Tyr Asn Ser Pro Ser Val Thr Asp Pro Thr Leu Ile Ala Asp Ala Leu 
            180                 185                 190         


Asp Lys Lys Ile Ala Glu Phe Asp Thr Val Glu Asp Leu Leu Lys Tyr 
        195                 200                 205             


Phe Asn Pro Glu Ser Trp Gln Glu Asp Leu Glu Asn Met Tyr Leu Asp 
    210                 215                 220                 


Thr Pro Arg Tyr Arg Gly Arg Ser Tyr His Asp Arg Lys Ser Lys Val 
225                 230                 235                 240 


Asp Leu Asp Arg Leu Asn Asp Asp Ala Lys Arg Tyr Ser Cys Thr Pro 
                245                 250                 255     


Arg Asn Tyr Ser Val Asn Ile Arg Glu Glu Leu Lys Leu Ala Asn Val 
            260                 265                 270         


Val Phe Phe Pro Arg Cys Leu Leu Val Gln Arg Cys Gly Gly Asn Cys 
        275                 280                 285             


Gly Cys Gly Thr Val Asn Trp Arg Ser Cys Thr Cys Asn Ser Gly Lys 
    290                 295                 300                 


Thr Val Lys Lys Tyr His Glu Val Leu Gln Phe Glu Pro Gly His Ile 
305                 310                 315                 320 


Lys Arg Arg Gly Arg Ala Lys Thr Met Ala Leu Val Asp Ile Gln Leu 
                325                 330                 335     


Asp His His Glu Arg Cys Asp Cys Ile Cys Ser Ser Arg Pro Pro Arg 
            340                 345                 350         


<210> 46
<211> 248
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble SCF"

<400> 46
Glu Gly Ile Cys Arg Asn Arg Val Thr Asn Asn Val Lys Asp Val Thr 
1               5                   10                  15      


Lys Leu Val Ala Asn Leu Pro Lys Asp Tyr Met Ile Thr Leu Lys Tyr 
            20                  25                  30          


Val Pro Gly Met Asp Val Leu Pro Ser His Cys Trp Ile Ser Glu Met 
        35                  40                  45              


Val Val Gln Leu Ser Asp Ser Leu Thr Asp Leu Leu Asp Lys Phe Ser 
    50                  55                  60                  


Asn Ile Ser Glu Gly Leu Ser Asn Tyr Ser Ile Ile Asp Lys Leu Val 
65                  70                  75                  80  


Asn Ile Val Asp Asp Leu Val Glu Cys Val Lys Glu Asn Ser Ser Lys 
                85                  90                  95      


Asp Leu Lys Lys Ser Phe Lys Ser Pro Glu Pro Arg Leu Phe Thr Pro 
            100                 105                 110         


Glu Glu Phe Phe Arg Ile Phe Asn Arg Ser Ile Asp Ala Phe Lys Asp 
        115                 120                 125             


Phe Val Val Ala Ser Glu Thr Ser Asp Cys Val Val Ser Ser Thr Leu 
    130                 135                 140                 


Ser Pro Glu Lys Asp Ser Arg Val Ser Val Thr Lys Pro Phe Met Leu 
145                 150                 155                 160 


Pro Pro Val Ala Ala Ser Ser Leu Arg Asn Asp Ser Ser Ser Ser Asn 
                165                 170                 175     


Arg Lys Ala Lys Asn Pro Pro Gly Asp Ser Ser Leu His Trp Ala Ala 
            180                 185                 190         


Met Ala Leu Pro Ala Leu Phe Ser Leu Ile Ile Gly Phe Ala Phe Gly 
        195                 200                 205             


Ala Leu Tyr Trp Lys Lys Arg Gln Pro Ser Leu Thr Arg Ala Val Glu 
    210                 215                 220                 


Asn Ile Gln Ile Asn Glu Glu Asp Asn Glu Ile Ser Met Leu Gln Glu 
225                 230                 235                 240 


Lys Glu Arg Glu Phe Gln Glu Val 
                245             


<210> 47
<211> 209
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble FLT3L"

<400> 47
Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu 
145                 150                 155                 160 


Leu Leu Leu Leu Leu Leu Pro Val Gly Leu Leu Leu Leu Ala Ala Ala 
                165                 170                 175     


Trp Cys Leu His Trp Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly 
            180                 185                 190         


Glu Gln Val Pro Pro Val Pro Ser Pro Gln Asp Leu Leu Leu Val Glu 
        195                 200                 205             


His 
    


<210> 48
<211> 360
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble MICA"

<400> 48
Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser Gly Lys Val Leu Val Leu Gln Ser His Trp Gln Thr Phe His 
        275                 280                 285             


Val Ser Ala Val Ala Ala Ala Ala Ile Phe Val Ile Ile Ile Phe Tyr 
    290                 295                 300                 


Val Arg Cys Cys Lys Lys Lys Thr Ser Ala Ala Glu Gly Pro Glu Leu 
305                 310                 315                 320 


Val Ser Leu Gln Val Leu Asp Gln His Pro Val Gly Thr Ser Asp His 
                325                 330                 335     


Arg Asp Ala Thr Gln Leu Gly Phe Gln Pro Leu Met Ser Asp Leu Gly 
            340                 345                 350         


Ser Thr Gly Ser Thr Glu Gly Ala 
        355                 360 


<210> 49
<211> 361
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble MICB"

<400> 49
Ala Glu Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp 
1               5                   10                  15      


Glu Ser Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Ala Glu Asp Val Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr 
    50                  55                  60                  


Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val 
                85                  90                  95      


Cys Glu Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala 
145                 150                 155                 160 


Met Gln Ala Asp Cys Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Ala Ile Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Cys Ser 
            180                 185                 190         


Glu Val Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe 
        195                 200                 205             


Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu 
    210                 215                 220                 


Ser His Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly 
225                 230                 235                 240 


Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln 
                245                 250                 255     


Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr His Pro 
            260                 265                 270         


Val Pro Ser Gly Lys Val Leu Val Leu Gln Ser Gln Arg Thr Asp Phe 
        275                 280                 285             


Pro Tyr Val Ser Ala Ala Met Pro Cys Phe Val Ile Ile Ile Ile Leu 
    290                 295                 300                 


Cys Val Pro Cys Cys Lys Lys Lys Thr Ser Ala Ala Glu Gly Pro Glu 
305                 310                 315                 320 


Leu Val Ser Leu Gln Val Leu Asp Gln His Pro Val Gly Thr Gly Asp 
                325                 330                 335     


His Arg Asp Ala Ala Gln Leu Gly Phe Gln Pro Leu Met Ser Ala Thr 
            340                 345                 350         


Gly Ser Thr Gly Ser Thr Glu Gly Ala 
        355                 360     


<210> 50
<211> 190
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble ULBP1"

<400> 50
Trp Val Asp Thr His Cys Leu Cys Tyr Asp Phe Ile Ile Thr Pro Lys 
1               5                   10                  15      


Ser Arg Pro Glu Pro Gln Trp Cys Glu Val Gln Gly Leu Val Asp Glu 
            20                  25                  30          


Arg Pro Phe Leu His Tyr Asp Cys Val Asn His Lys Ala Lys Ala Phe 
        35                  40                  45              


Ala Ser Leu Gly Lys Lys Val Asn Val Thr Lys Thr Trp Glu Glu Gln 
    50                  55                  60                  


Thr Glu Thr Leu Arg Asp Val Val Asp Phe Leu Lys Gly Gln Leu Leu 
65                  70                  75                  80  


Asp Ile Gln Val Glu Asn Leu Ile Pro Ile Glu Pro Leu Thr Leu Gln 
                85                  90                  95      


Ala Arg Met Ser Cys Glu His Glu Ala His Gly His Gly Arg Gly Ser 
            100                 105                 110         


Trp Gln Phe Leu Phe Asn Gly Gln Lys Phe Leu Leu Phe Asp Ser Asn 
        115                 120                 125             


Asn Arg Lys Trp Thr Ala Leu His Pro Gly Ala Lys Lys Met Thr Glu 
    130                 135                 140                 


Lys Trp Glu Lys Asn Arg Asp Val Thr Met Phe Phe Gln Lys Ile Ser 
145                 150                 155                 160 


Leu Gly Asp Cys Lys Met Trp Leu Glu Glu Phe Leu Met Tyr Trp Glu 
                165                 170                 175     


Gln Met Leu Asp Pro Thr Lys Pro Pro Ser Leu Ala Pro Gly 
            180                 185                 190 


<210> 51
<211> 191
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble ULBP2"

<400> 51
Gly Arg Ala Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro 
1               5                   10                  15      


Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp 
            20                  25                  30          


Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro 
        35                  40                  45              


Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala 
    50                  55                  60                  


Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu 
65                  70                  75                  80  


Arg Asp Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu 
                85                  90                  95      


Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly 
            100                 105                 110         


Ser Trp Gln Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser 
        115                 120                 125             


Glu Lys Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys 
    130                 135                 140                 


Glu Lys Trp Glu Asn Asp Lys Val Val Ala Met Ser Phe His Tyr Phe 
145                 150                 155                 160 


Ser Met Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met 
                165                 170                 175     


Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Leu Ala Met Ser 
            180                 185                 190     


<210> 52
<211> 188
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble ULBP3"

<400> 52
Asp Ala His Ser Leu Trp Tyr Asn Phe Thr Ile Ile His Leu Pro Arg 
1               5                   10                  15      


His Gly Gln Gln Trp Cys Glu Val Gln Ser Gln Val Asp Gln Lys Asn 
            20                  25                  30          


Phe Leu Ser Tyr Asp Cys Gly Ser Asp Lys Val Leu Ser Met Gly His 
        35                  40                  45              


Leu Glu Glu Gln Leu Tyr Ala Thr Asp Ala Trp Gly Lys Gln Leu Glu 
    50                  55                  60                  


Met Leu Arg Glu Val Gly Gln Arg Leu Arg Leu Glu Leu Ala Asp Thr 
65                  70                  75                  80  


Glu Leu Glu Asp Phe Thr Pro Ser Gly Pro Leu Thr Leu Gln Val Arg 
                85                  90                  95      


Met Ser Cys Glu Cys Glu Ala Asp Gly Tyr Ile Arg Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Arg Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg 
        115                 120                 125             


Lys Trp Thr Val Val His Ala Gly Ala Arg Arg Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Lys Asp Ser Gly Leu Thr Thr Phe Phe Lys Met Val Ser Met Arg 
145                 150                 155                 160 


Asp Cys Lys Ser Trp Leu Arg Asp Phe Leu Met His Arg Lys Lys Arg 
                165                 170                 175     


Leu Glu Pro Thr Ala Pro Pro Thr Met Ala Pro Gly 
            180                 185             


<210> 53
<211> 233
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble ULBP4"

<400> 53
His Ser Leu Cys Phe Asn Phe Thr Ile Lys Ser Leu Ser Arg Pro Gly 
1               5                   10                  15      


Gln Pro Trp Cys Glu Ala Gln Val Phe Leu Asn Lys Asn Leu Phe Leu 
            20                  25                  30          


Gln Tyr Asn Ser Asp Asn Asn Met Val Lys Pro Leu Gly Leu Leu Gly 
        35                  40                  45              


Lys Lys Val Tyr Ala Thr Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu 
    50                  55                  60                  


Gly Glu Val Gly Arg Asp Leu Arg Met Leu Leu Cys Asp Ile Lys Pro 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Asp Pro Ser Thr Leu Gln Val Glu Met Phe Cys 
                85                  90                  95      


Gln Arg Glu Ala Glu Arg Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr 
            100                 105                 110         


Asn Gly Glu Lys Ser Leu Leu Phe Asp Ala Met Asn Met Thr Trp Thr 
        115                 120                 125             


Val Ile Asn His Glu Ala Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp 
    130                 135                 140                 


Arg Gly Leu Glu Lys Tyr Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp 
145                 150                 155                 160 


His Trp Leu Arg Glu Phe Leu Gly His Trp Glu Ala Met Pro Glu Pro 
                165                 170                 175     


Thr Val Ser Pro Val Asn Ala Ser Asp Ile His Trp Ser Ser Ser Ser 
            180                 185                 190         


Leu Pro Asp Arg Trp Ile Ile Leu Gly Ala Phe Ile Leu Leu Val Leu 
        195                 200                 205             


Met Gly Ile Val Leu Ile Cys Val Trp Trp Gln Asn Gly Glu Trp Gln 
    210                 215                 220                 


Ala Gly Leu Trp Pro Leu Arg Thr Ser 
225                 230             


<210> 54
<211> 193
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble ULBP5"

<400> 54
Gly Leu Ala Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro 
1               5                   10                  15      


Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp 
            20                  25                  30          


Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Ser Lys Thr Val Thr Pro 
        35                  40                  45              


Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala 
    50                  55                  60                  


Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu 
65                  70                  75                  80  


Leu Asp Ile Gln Leu Glu Asn Tyr Ile Pro Lys Glu Pro Leu Thr Leu 
                85                  90                  95      


Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Gly Ser Gly 
            100                 105                 110         


Ser Trp Gln Leu Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser 
        115                 120                 125             


Glu Asn Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys 
    130                 135                 140                 


Glu Lys Trp Glu Asn Asp Lys Asp Met Thr Met Ser Phe His Tyr Ile 
145                 150                 155                 160 


Ser Met Gly Asp Cys Thr Gly Trp Leu Glu Asp Phe Leu Met Gly Met 
                165                 170                 175     


Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Pro Thr Met Ser Ser 
            180                 185                 190         


Gly 
    


<210> 55
<211> 193
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human Soluble ULBP6"

<400> 55
Arg Arg Asp Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro 
1               5                   10                  15      


Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp 
            20                  25                  30          


Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro 
        35                  40                  45              


Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Met Ala Trp Lys Ala 
    50                  55                  60                  


Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu 
65                  70                  75                  80  


Leu Asp Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu 
                85                  90                  95      


Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly 
            100                 105                 110         


Ser Trp Gln Phe Ser Ile Asp Gly Gln Thr Phe Leu Leu Phe Asp Ser 
        115                 120                 125             


Glu Lys Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys 
    130                 135                 140                 


Glu Lys Trp Glu Asn Asp Lys Asp Val Ala Met Ser Phe His Tyr Ile 
145                 150                 155                 160 


Ser Met Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met 
                165                 170                 175     


Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Leu Ala Met Ser Ser 
            180                 185                 190         


Gly 
    


<210> 56
<211> 136
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Soluble TGFbetaRII receptor, first sequence"

<400> 56
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135     


<210> 57
<211> 408
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Soluble TGFbetaRII receptor, first sequence"

<400> 57
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcacgatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgat                   408


<210> 58

<400> 58
000


<210> 59

<400> 59
000


<210> 60
<211> 287
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Soluble TGFbetaRII receptor"

<400> 60
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
        275                 280                 285         


<210> 61
<211> 861
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Soluble TGFbetaRII receptor"

<400> 61
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcacgatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgcaca      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga c                                                861


<210> 62
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 62
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210> 63
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 63
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctcc             54


<210> 64
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 64
atgaagtggg tcacatttat ctctttactg ttcctcttct ccagcgccta cagc             54


<210> 65
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 65
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctcc             54


<210> 66
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 66
Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Leu Gly Val Asn Cys 
1               5                   10                  15      


<210> 67
<211> 58
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 67
Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly 
    50                  55              


<210> 68
<211> 97
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 68
Met Pro Asn His Gln Ser Gly Ser Pro Thr Gly Ser Ser Asp Leu Leu 
1               5                   10                  15      


Leu Ser Gly Lys Lys Gln Arg Pro His Leu Ala Leu Arg Arg Lys Arg 
            20                  25                  30          


Arg Arg Glu Met Arg Lys Ile Asn Arg Lys Val Arg Arg Met Asn Leu 
        35                  40                  45              


Ala Pro Ile Lys Glu Lys Thr Ala Trp Gln His Leu Gln Ala Leu Ile 
    50                  55                  60                  


Ser Glu Ala Glu Glu Val Leu Lys Thr Ser Gln Thr Pro Gln Asn Ser 
65                  70                  75                  80  


Leu Thr Leu Phe Leu Ala Leu Leu Ser Val Leu Gly Pro Pro Val Thr 
                85                  90                  95      


Gly 
    


<210> 69
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 69
Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Cys Gln Gly Val Val Ser 
            20                  25                  30  


<210> 70
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      AviTag sequence"

<400> 70
Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210> 71
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Calmodulin-tag sequence"

<400> 71
Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210> 72
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Polyglutamate tag sequence"

<400> 72
Glu Glu Glu Glu Glu Glu 
1               5       


<210> 73
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      E-tag sequence"

<400> 73
Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210> 74
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      FLAG-tag sequence"

<400> 74
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 75
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      HA-tag sequence"

<400> 75
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 76
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      His-tag sequence"

<400> 76
His His His His His 
1               5   


<210> 77
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      His-tag sequence"

<400> 77
His His His His His His 
1               5       


<210> 78
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      His-tag sequence"

<400> 78
His His His His His His His 
1               5           


<210> 79
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      His-tag sequence"

<400> 79
His His His His His His His His 
1               5               


<210> 80
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      His-tag sequence"

<400> 80
His His His His His His His His His 
1               5                   


<210> 81
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      His-tag sequence"

<400> 81
His His His His His His His His His His 
1               5                   10  


<210> 82
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Myc-tag sequence"

<400> 82
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 83
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      NE-tag sequence"

<400> 83
Thr Lys Glu Asn Pro Arg Ser Asn Gln Glu Glu Ser Tyr Asp Asp Asn 
1               5                   10                  15      


Glu Ser 
        


<210> 84
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      S-tag sequence"

<400> 84
Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210> 85
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      SBP-tag sequence"

<400> 85
Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210> 86
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Softag 1 sequence"

<400> 86
Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210> 87
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Softag 3 sequence"

<400> 87
Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210> 88
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Spot-tag sequence"

<400> 88
Pro Asp Arg Val Arg Ala Val Ser His Trp Ser Ser 
1               5                   10          


<210> 89
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Strep-tag sequence"

<400> 89
Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210> 90
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TC tag sequence"

<400> 90
Cys Cys Pro Gly Cys Cys 
1               5       


<210> 91
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Ty tag sequence"

<400> 91
Glu Val His Thr Asn Gln Asp Pro Leu Asp 
1               5                   10  


<210> 92
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      V5 tag sequence"

<400> 92
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210> 93
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      VSV-tag sequence"

<400> 93
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210> 94
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Xpress tag sequence"

<400> 94
Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210> 95

<400> 95
000


<210> 96
<211> 219
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Mutant Soluble Human Tissue Factor Domain"

<400> 96
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Ala Thr Ala Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Ala Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Ala Arg Asn Asn Thr Ala Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


<210> 97
<211> 219
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Mutant Soluble Human Tissue Factor Domain"

<400> 97
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Ala Thr Ala Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Ala Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Ala Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Ala Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Ala Arg Asn Asn Thr Ala Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


<210> 98

<400> 98
000


<210> 99
<211> 723
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Anti-CD3 scFv"

<400> 99
cagatcgtgc tgacccaaag ccccgccatc atgagcgcta gccccggtga gaaggtgacc       60

atgacatgct ccgcttccag ctccgtgtcc tacatgaact ggtatcagca gaaaagcgga      120

accagcccca aaaggtggat ctacgacacc agcaagctgg cctccggagt gcccgctcat      180

ttccggggct ctggatccgg caccagctac tctttaacca tttccggcat ggaagctgaa      240

gacgctgcca cctactattg ccagcaatgg agcagcaacc ccttcacatt cggatctggc      300

accaagctcg aaatcaatcg tggaggaggt ggcagcggcg gcggtggatc cggcggagga      360

ggaagccaag ttcaactcca gcagagcggc gctgaactgg cccggcccgg cgcctccgtc      420

aagatgagct gcaaggcttc cggctataca tttactcgtt acacaatgca ttgggtcaag      480

cagaggcccg gtcaaggttt agagtggatc ggatatatca acccttcccg gggctacacc      540

aactataacc aaaagttcaa ggataaagcc actttaacca ctgacaagag ctcctccacc      600

gcctacatgc agctgtcctc tttaaccagc gaggactccg ctgtttacta ctgcgctagg      660

tattacgacg accactactg tttagactat tggggacaag gtaccacttt aaccgtcagc      720

agc                                                                    723


<210> 100
<211> 236
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Anti-CD28 scFv"

<400> 100
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
            20                  25                  30          


Ile Gln Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile Asn Pro Tyr Asn Asp Tyr Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ile Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Gly Asp Gly Asn Tyr Trp Gly Arg Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Glu Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu 
    130                 135                 140                 


Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser 
145                 150                 155                 160 


Ser Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu 
                165                 170                 175     


Cys Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Pro Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
        195                 200                 205             


Ala Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Tyr His Arg Ser Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Thr Lys Arg 
225                 230                 235     


<210> 101
<211> 708
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Anti-CD28 scFv"

<400> 101
gtccagctgc agcagagcgg acccgaactc gtgaaacccg gtgcttccgt gaaaatgtct       60

tgtaaggcca gcggatacac cttcacctcc tatgtgatcc agtgggtcaa acagaagccc      120

ggacaaggtc tcgagtggat cggcagcatc aacccttaca acgactatac caaatacaac      180

gagaagttta agggaaaggc tactttaacc tccgacaaaa gctccatcac agcctacatg      240

gagttcagct ctttaacatc cgaggacagc gctctgtact attgcgcccg gtggggcgac      300

ggcaattact ggggacgggg cacaacactg accgtgagca gcggaggcgg aggctccggc      360

ggaggcggat ctggcggtgg cggctccgac atcgagatga cccagtcccc cgctatcatg      420

tccgcctctt taggcgagcg ggtcacaatg acttgtacag cctcctccag cgtctcctcc      480

tcctacttcc attggtacca acagaaaccc ggaagctccc ctaaactgtg catctacagc      540

accagcaatc tcgccagcgg cgtgccccct aggttttccg gaagcggaag caccagctac      600

tctttaacca tctcctccat ggaggctgag gatgccgcca cctacttttg tcaccagtac      660

caccggtccc ccaccttcgg aggcggcacc aaactggaga caaagagg                   708


<210> 102

<400> 102
000


<210> 103

<400> 103
000


<210> 104

<400> 104
000


<210> 105

<400> 105
000


<210> 106
<211> 399
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-2"

<400> 106
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct tttgtcaaag catcatctca acactaact                             399


<210> 107
<211> 399
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-2"

<400> 107
gcccccacct cctcctccac caagaagacc cagctgcagc tggagcattt actgctggat       60

ttacagatga ttttaaacgg catcaacaac tacaagaacc ccaagctgac tcgtatgctg      120

accttcaagt tctacatgcc caagaaggcc accgagctga agcatttaca gtgtttagag      180

gaggagctga agcccctcga ggaggtgctg aatttagccc agtccaagaa tttccattta      240

aggccccggg atttaatcag caacatcaac gtgatcgttt tagagctgaa gggctccgag      300

accaccttca tgtgcgagta cgccgacgag accgccacca tcgtggagtt tttaaatcgt      360

tggatcacct tctgccagtc catcatctcc actttaacc                             399


<210> 108
<211> 485
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-2/TF/IL-2"

<400> 108
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn 
    130                 135                 140                 


Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro 
145                 150                 155                 160 


Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly 
                165                 170                 175     


Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu 
            180                 185                 190         


Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val 
        195                 200                 205             


Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu 
    210                 215                 220                 


Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn 
225                 230                 235                 240 


Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val 
                245                 250                 255     


Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr 
            260                 265                 270         


Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu 
        275                 280                 285             


Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn 
    290                 295                 300                 


Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe 
305                 310                 315                 320 


Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr 
                325                 330                 335     


Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
            340                 345                 350         


Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
        355                 360                 365             


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
    370                 375                 380                 


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
385                 390                 395                 400 


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
                405                 410                 415     


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
            420                 425                 430         


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
        435                 440                 445             


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
    450                 455                 460                 


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
465                 470                 475                 480 


Ile Ser Thr Leu Thr 
                485 


<210> 109
<211> 1455
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-2/TF/IL-2"

<400> 109
gcccccacct cctcctccac caagaagacc cagctgcagc tggagcattt actgctggat       60

ttacagatga ttttaaacgg catcaacaac tacaagaacc ccaagctgac tcgtatgctg      120

accttcaagt tctacatgcc caagaaggcc accgagctga agcatttaca gtgtttagag      180

gaggagctga agcccctcga ggaggtgctg aatttagccc agtccaagaa tttccattta      240

aggccccggg atttaatcag caacatcaac gtgatcgttt tagagctgaa gggctccgag      300

accaccttca tgtgcgagta cgccgacgag accgccacca tcgtggagtt tttaaatcgt      360

tggatcacct tctgccagtc catcatctcc actttaacca gcggcacaac caacacagtc      420

gctgcctata acctcacttg gaagagcacc aacttcaaaa ccatcctcga atgggaaccc      480

aaacccgtta accaagttta caccgtgcag atcagcacca agtccggcga ctggaagtcc      540

aaatgtttct ataccaccga caccgagtgc gatctcaccg atgagatcgt gaaagatgtg      600

aaacagacct acctcgcccg ggtgtttagc taccccgccg gcaatgtgga gagcactggt      660

tccgctggcg agcctttata cgagaacagc cccgaattta ccccttacct cgagaccaat      720

ttaggacagc ccaccatcca aagctttgag caagttggca caaaggtgaa tgtgacagtg      780

gaggacgagc ggactttagt gcggcggaac aacacctttc tcagcctccg ggatgtgttc      840

ggcaaagatt taatctacac actgtattac tggaagtcct cttcctccgg caagaagaca      900

gctaaaacca acacaaacga gtttttaatc gacgtggata aaggcgaaaa ctactgtttc      960

agcgtgcaag ctgtgatccc ctcccggacc gtgaatagga aaagcaccga tagccccgtt     1020

gagtgcatgg gccaagaaaa gggcgagttc cgggaggcac ctacttcaag ttctacaaag     1080

aaaacacagc tacaactgga gcatttactg ctggatttac agatgatttt gaatggaatt     1140

aataattaca agaatcccaa actcaccagg atgctcacat ttaagtttta catgcccaag     1200

aaggccacag aactgaaaca tcttcagtgt ctagaagaag aactcaaacc tctggaggaa     1260

gtgctaaatt tagctcaaag caaaaacttt cacttaagac ccagggactt aatcagcaat     1320

atcaacgtaa tagttctgga actaaaggga tctgaaacaa cattcatgtg tgaatatgct     1380

gatgagacag caaccattgt agaatttctg aacagatgga ttaccttttg tcaaagcatc     1440

atctcaacac taact                                                      1455


<210> 110
<211> 503
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-2/TF/IL-2 with signal sequence"

<400> 110
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
            20                  25                  30          


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
        35                  40                  45              


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
    50                  55                  60                  


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
65                  70                  75                  80  


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
                85                  90                  95      


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
            100                 105                 110         


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
        115                 120                 125             


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
    130                 135                 140                 


Ser Ile Ile Ser Thr Leu Thr Ser Gly Thr Thr Asn Thr Val Ala Ala 
145                 150                 155                 160 


Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp 
                165                 170                 175     


Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys 
            180                 185                 190         


Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys 
        195                 200                 205             


Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala 
    210                 215                 220                 


Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala 
225                 230                 235                 240 


Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu 
                245                 250                 255     


Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr 
            260                 265                 270         


Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn 
        275                 280                 285             


Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr 
    290                 295                 300                 


Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys 
305                 310                 315                 320 


Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr 
                325                 330                 335     


Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys 
            340                 345                 350         


Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe 
        355                 360                 365             


Arg Glu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
    370                 375                 380                 


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
385                 390                 395                 400 


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
                405                 410                 415     


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
            420                 425                 430         


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
        435                 440                 445             


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
    450                 455                 460                 


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
465                 470                 475                 480 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
                485                 490                 495     


Ser Ile Ile Ser Thr Leu Thr 
            500             


<210> 111
<211> 1509
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-2/TF/IL-2 with signal sequence"

<400> 111
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccgccccc       60

acctcctcct ccaccaagaa gacccagctg cagctggagc atttactgct ggatttacag      120

atgattttaa acggcatcaa caactacaag aaccccaagc tgactcgtat gctgaccttc      180

aagttctaca tgcccaagaa ggccaccgag ctgaagcatt tacagtgttt agaggaggag      240

ctgaagcccc tcgaggaggt gctgaattta gcccagtcca agaatttcca tttaaggccc      300

cgggatttaa tcagcaacat caacgtgatc gttttagagc tgaagggctc cgagaccacc      360

ttcatgtgcg agtacgccga cgagaccgcc accatcgtgg agtttttaaa tcgttggatc      420

accttctgcc agtccatcat ctccacttta accagcggca caaccaacac agtcgctgcc      480

tataacctca cttggaagag caccaacttc aaaaccatcc tcgaatggga acccaaaccc      540

gttaaccaag tttacaccgt gcagatcagc accaagtccg gcgactggaa gtccaaatgt      600

ttctatacca ccgacaccga gtgcgatctc accgatgaga tcgtgaaaga tgtgaaacag      660

acctacctcg cccgggtgtt tagctacccc gccggcaatg tggagagcac tggttccgct      720

ggcgagcctt tatacgagaa cagccccgaa tttacccctt acctcgagac caatttagga      780

cagcccacca tccaaagctt tgagcaagtt ggcacaaagg tgaatgtgac agtggaggac      840

gagcggactt tagtgcggcg gaacaacacc tttctcagcc tccgggatgt gttcggcaaa      900

gatttaatct acacactgta ttactggaag tcctcttcct ccggcaagaa gacagctaaa      960

accaacacaa acgagttttt aatcgacgtg gataaaggcg aaaactactg tttcagcgtg     1020

caagctgtga tcccctcccg gaccgtgaat aggaaaagca ccgatagccc cgttgagtgc     1080

atgggccaag aaaagggcga gttccgggag gcacctactt caagttctac aaagaaaaca     1140

cagctacaac tggagcattt actgctggat ttacagatga ttttgaatgg aattaataat     1200

tacaagaatc ccaaactcac caggatgctc acatttaagt tttacatgcc caagaaggcc     1260

acagaactga aacatcttca gtgtctagaa gaagaactca aacctctgga ggaagtgcta     1320

aatttagctc aaagcaaaaa ctttcactta agacccaggg acttaatcag caatatcaac     1380

gtaatagttc tggaactaaa gggatctgaa acaacattca tgtgtgaata tgctgatgag     1440

acagcaacca ttgtagaatt tctgaacaga tggattacct tttgtcaaag catcatctca     1500

acactaact                                                             1509


<210> 112
<211> 342
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-15"

<400> 112
aactgggtga acgtgatcag cgatttaaag aagatcgagg atttaatcca gagcatgcac       60

atcgacgcca ctctgtacac tgagagcgac gtgcacccta gctgcaaggt gactgccatg      120

aagtgctttt tactggagct gcaagttatc tctttagaga gcggcgatgc cagcatccac      180

gacactgtgg agaatttaat cattttagcc aacaactctt taagcagcaa cggcaacgtg      240

acagagagcg gctgcaagga gtgcgaggag ctggaggaga agaacatcaa ggagttttta      300

cagagcttcg tgcacatcgt gcagatgttc atcaacacta gc                         342


<210> 113
<211> 342
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-15"

<400> 113
aactgggtga acgtcatcag cgatttaaag aagatcgaag atttaattca gtccatgcat       60

atcgacgcca ctttatacac agaatccgac gtgcacccct cttgtaaggt gaccgccatg      120

aaatgttttt tactggagct gcaagttatc tctttagaga gcggagacgc tagcatccac      180

gacaccgtgg agaatttaat cattttagcc aataactctt tatccagcaa cggcaacgtg      240

acagagtccg gctgcaagga gtgcgaagag ctggaggaga agaacatcaa ggagtttctg      300

caatcctttg tgcacattgt ccagatgttc atcaatacct cc                         342


<210> 114
<211> 447
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-15/TF/IL-15"

<400> 114
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp 
        115                 120                 125             


Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val 
    130                 135                 140                 


Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys 
145                 150                 155                 160 


Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu 
                165                 170                 175     


Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr 
            180                 185                 190         


Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr 
        195                 200                 205             


Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln 
    210                 215                 220                 


Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr 
225                 230                 235                 240 


Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser 
                245                 250                 255     


Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp 
            260                 265                 270         


Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu 
        275                 280                 285             


Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln 
    290                 295                 300                 


Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro 
305                 310                 315                 320 


Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val 
                325                 330                 335     


Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met 
            340                 345                 350         


His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys 
        355                 360                 365             


Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser 
    370                 375                 380                 


Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile 
385                 390                 395                 400 


Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser 
                405                 410                 415     


Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe 
            420                 425                 430         


Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
        435                 440                 445         


<210> 115
<211> 1341
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-15/TF/IL-15"

<400> 115
aactgggtga acgtgatcag cgatttaaag aagatcgagg atttaatcca gagcatgcac       60

atcgacgcca ctctgtacac tgagagcgac gtgcacccta gctgcaaggt gactgccatg      120

aagtgctttt tactggagct gcaagttatc tctttagaga gcggcgatgc cagcatccac      180

gacactgtgg agaatttaat cattttagcc aacaactctt taagcagcaa cggcaacgtg      240

acagagagcg gctgcaagga gtgcgaggag ctggaggaga agaacatcaa ggagttttta      300

cagagcttcg tgcacatcgt gcagatgttc atcaacacta gcagcggcac aaccaacaca      360

gtcgctgcct ataacctcac ttggaagagc accaacttca aaaccatcct cgaatgggaa      420

cccaaacccg ttaaccaagt ttacaccgtg cagatcagca ccaagtccgg cgactggaag      480

tccaaatgtt tctataccac cgacaccgag tgcgatctca ccgatgagat cgtgaaagat      540

gtgaaacaga cctacctcgc ccgggtgttt agctaccccg ccggcaatgt ggagagcact      600

ggttccgctg gcgagccttt atacgagaac agccccgaat ttacccctta cctcgagacc      660

aatttaggac agcccaccat ccaaagcttt gagcaagttg gcacaaaggt gaatgtgaca      720

gtggaggacg agcggacttt agtgcggcgg aacaacacct ttctcagcct ccgggatgtg      780

ttcggcaaag atttaatcta cacactgtat tactggaagt cctcttcctc cggcaagaag      840

acagctaaaa ccaacacaaa cgagttttta atcgacgtgg ataaaggcga aaactactgt      900

ttcagcgtgc aagctgtgat cccctcccgg accgtgaata ggaaaagcac cgatagcccc      960

gttgagtgca tgggccaaga aaagggcgag ttccgggaga actgggtgaa cgtcatcagc     1020

gatttaaaga agatcgaaga tttaattcag tccatgcata tcgacgccac tttatacaca     1080

gaatccgacg tgcacccctc ttgtaaggtg accgccatga aatgtttttt actggagctg     1140

caagttatct ctttagagag cggagacgct agcatccacg acaccgtgga gaatttaatc     1200

attttagcca ataactcttt atccagcaac ggcaacgtga cagagtccgg ctgcaaggag     1260

tgcgaagagc tggaggagaa gaacatcaag gagtttctgc aatcctttgt gcacattgtc     1320

cagatgttca tcaatacctc c                                               1341


<210> 116
<211> 465
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-15/TF/IL-15 with signal sequence"

<400> 116
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu 
    130                 135                 140                 


Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys 
145                 150                 155                 160 


Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp 
                165                 170                 175     


Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr 
            180                 185                 190         


Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe 
        195                 200                 205             


Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro 
    210                 215                 220                 


Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu 
225                 230                 235                 240 


Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn 
                245                 250                 255     


Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe 
            260                 265                 270         


Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr 
        275                 280                 285             


Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr 
    290                 295                 300                 


Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser 
305                 310                 315                 320 


Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp 
                325                 330                 335     


Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn 
            340                 345                 350         


Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln 
        355                 360                 365             


Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro 
    370                 375                 380                 


Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val 
385                 390                 395                 400 


Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn 
                405                 410                 415     


Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr 
            420                 425                 430         


Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys 
        435                 440                 445             


Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr 
    450                 455                 460                 


Ser 
465 


<210> 117
<211> 1395
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-15/TF/IL-15 with signal sequence"

<400> 117
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccaactgg       60

gtgaacgtga tcagcgattt aaagaagatc gaggatttaa tccagagcat gcacatcgac      120

gccactctgt acactgagag cgacgtgcac cctagctgca aggtgactgc catgaagtgc      180

tttttactgg agctgcaagt tatctcttta gagagcggcg atgccagcat ccacgacact      240

gtggagaatt taatcatttt agccaacaac tctttaagca gcaacggcaa cgtgacagag      300

agcggctgca aggagtgcga ggagctggag gagaagaaca tcaaggagtt tttacagagc      360

ttcgtgcaca tcgtgcagat gttcatcaac actagcagcg gcacaaccaa cacagtcgct      420

gcctataacc tcacttggaa gagcaccaac ttcaaaacca tcctcgaatg ggaacccaaa      480

cccgttaacc aagtttacac cgtgcagatc agcaccaagt ccggcgactg gaagtccaaa      540

tgtttctata ccaccgacac cgagtgcgat ctcaccgatg agatcgtgaa agatgtgaaa      600

cagacctacc tcgcccgggt gtttagctac cccgccggca atgtggagag cactggttcc      660

gctggcgagc ctttatacga gaacagcccc gaatttaccc cttacctcga gaccaattta      720

ggacagccca ccatccaaag ctttgagcaa gttggcacaa aggtgaatgt gacagtggag      780

gacgagcgga ctttagtgcg gcggaacaac acctttctca gcctccggga tgtgttcggc      840

aaagatttaa tctacacact gtattactgg aagtcctctt cctccggcaa gaagacagct      900

aaaaccaaca caaacgagtt tttaatcgac gtggataaag gcgaaaacta ctgtttcagc      960

gtgcaagctg tgatcccctc ccggaccgtg aataggaaaa gcaccgatag ccccgttgag     1020

tgcatgggcc aagaaaaggg cgagttccgg gagaactggg tgaacgtcat cagcgattta     1080

aagaagatcg aagatttaat tcagtccatg catatcgacg ccactttata cacagaatcc     1140

gacgtgcacc cctcttgtaa ggtgaccgcc atgaaatgtt ttttactgga gctgcaagtt     1200

atctctttag agagcggaga cgctagcatc cacgacaccg tggagaattt aatcatttta     1260

gccaataact ctttatccag caacggcaac gtgacagagt ccggctgcaa ggagtgcgaa     1320

gagctggagg agaagaacat caaggagttt ctgcaatcct ttgtgcacat tgtccagatg     1380

ttcatcaata cctcc                                                      1395


