                               SEQUENCE LISTING

<110> HCW BIOLOGICS, INC.
 
<120> MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF

<130> 47039-0005WO1

<140>
<141>

<150> 62/881,088 
<151> 2019-07-31

<150> 62/817,241 
<151> 2019-03-12

<150> 62/817,230 
<151> 2019-03-12

<150> 62/816,683
<151> 2019-03-11

<150> 62/749,506 
<151> 2018-10-23

<150> 62/749,007 
<151> 2018-10-22

<150> 62/746,832 
<151> 2018-10-17

<150> 62/725,043 
<151> 2018-08-30

<150> 62/725,010 
<151> 2018-08-30

<150> 62/724,969 
<151> 2018-08-30

<160> 226   

<170> PatentIn version 3.5

<210> 1
<211> 219
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Tissue factor"

<400> 1
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


<210> 2
<211> 657
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Tissue factor"

<400> 2
agcggcacaa ccaacacagt cgctgcctat aacctcactt ggaagagcac caacttcaaa       60

accatcctcg aatgggaacc caaacccgtt aaccaagttt acaccgtgca gatcagcacc      120

aagtccggcg actggaagtc caaatgtttc tataccaccg acaccgagtg cgatctcacc      180

gatgagatcg tgaaagatgt gaaacagacc tacctcgccc gggtgtttag ctaccccgcc      240

ggcaatgtgg agagcactgg ttccgctggc gagcctttat acgagaacag ccccgaattt      300

accccttacc tcgagaccaa tttaggacag cccaccatcc aaagctttga gcaagttggc      360

acaaaggtga atgtgacagt ggaggacgag cggactttag tgcggcggaa caacaccttt      420

ctcagcctcc gggatgtgtt cggcaaagat ttaatctaca cactgtatta ctggaagtcc      480

tcttcctccg gcaagaagac agctaaaacc aacacaaacg agtttttaat cgacgtggat      540

aaaggcgaaa actactgttt cagcgtgcaa gctgtgatcc cctcccggac cgtgaatagg      600

aaaagcaccg atagccccgt tgagtgcatg ggccaagaaa agggcgagtt ccgggag         657


<210> 3
<211> 219
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Tissue factor"

<400> 3
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Ala Thr Ala Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Ala Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Ala Arg Asn Asn Thr Ala Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


<210> 4
<211> 219
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Tissue factor"

<400> 4
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Ala Thr Ala Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Ala Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Ala Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Ala Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Ala Arg Asn Asn Thr Ala Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


<210> 5
<211> 223
<212> PRT
<213> Mus musculus 

<220>
<221> source
<223> /note="Tissue factor"

<400> 5
Ala Gly Ile Pro Glu Lys Ala Phe Asn Leu Thr Trp Ile Ser Thr Asp 
1               5                   10                  15      


Phe Lys Thr Ile Leu Glu Trp Gln Pro Lys Pro Thr Asn Tyr Thr Tyr 
            20                  25                  30          


Thr Val Gln Ile Ser Asp Arg Ser Arg Asn Trp Lys Asn Lys Cys Phe 
        35                  40                  45              


Ser Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp 
    50                  55                  60                  


Val Thr Trp Ala Tyr Glu Ala Lys Val Leu Ser Val Pro Arg Arg Asn 
65                  70                  75                  80  


Ser Val His Gly Asp Gly Asp Gln Leu Val Ile His Gly Glu Glu Pro 
                85                  90                  95      


Pro Phe Thr Asn Ala Pro Lys Phe Leu Pro Tyr Arg Asp Thr Asn Leu 
            100                 105                 110         


Gly Gln Pro Val Ile Gln Gln Phe Glu Gln Asp Gly Arg Lys Leu Asn 
        115                 120                 125             


Val Val Val Lys Asp Ser Leu Thr Leu Val Arg Lys Asn Gly Thr Phe 
    130                 135                 140                 


Leu Thr Leu Arg Gln Val Phe Gly Lys Asp Leu Gly Tyr Ile Ile Thr 
145                 150                 155                 160 


Tyr Arg Lys Gly Ser Ser Thr Gly Lys Lys Thr Asn Ile Thr Asn Thr 
                165                 170                 175     


Asn Glu Phe Ser Ile Asp Val Glu Glu Gly Val Ser Tyr Cys Phe Phe 
            180                 185                 190         


Val Gln Ala Met Ile Phe Ser Arg Lys Thr Asn Gln Asn Ser Pro Gly 
        195                 200                 205             


Ser Ser Thr Val Cys Thr Glu Gln Trp Lys Ser Phe Leu Gly Glu 
    210                 215                 220             


<210> 6
<211> 224
<212> PRT
<213> Rattus rattus 

<220>
<221> source
<223> /note="Tissue factor"

<400> 6
Ala Gly Thr Pro Pro Gly Lys Ala Phe Asn Leu Thr Trp Ile Ser Thr 
1               5                   10                  15      


Asp Phe Lys Thr Ile Leu Glu Trp Gln Pro Lys Pro Thr Asn Tyr Thr 
            20                  25                  30          


Tyr Thr Val Gln Ile Ser Asp Arg Ser Arg Asn Trp Lys Tyr Lys Cys 
        35                  40                  45              


Thr Gly Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
    50                  55                  60                  


Asp Val Asn Trp Thr Tyr Glu Ala Arg Val Leu Ser Val Pro Trp Arg 
65                  70                  75                  80  


Asn Ser Thr His Gly Lys Glu Thr Leu Phe Gly Thr His Gly Glu Glu 
                85                  90                  95      


Pro Pro Phe Thr Asn Ala Arg Lys Phe Leu Pro Tyr Arg Asp Thr Lys 
            100                 105                 110         


Ile Gly Gln Pro Val Ile Gln Lys Tyr Glu Gln Gly Gly Thr Lys Leu 
        115                 120                 125             


Lys Val Thr Val Lys Asp Ser Phe Thr Leu Val Arg Lys Asn Gly Thr 
    130                 135                 140                 


Phe Leu Thr Leu Arg Gln Val Phe Gly Asn Asp Leu Gly Tyr Ile Leu 
145                 150                 155                 160 


Thr Tyr Arg Lys Asp Ser Ser Thr Gly Arg Lys Thr Asn Thr Thr His 
                165                 170                 175     


Thr Asn Glu Phe Leu Ile Asp Val Glu Lys Gly Val Ser Tyr Cys Phe 
            180                 185                 190         


Phe Ala Gln Ala Val Ile Phe Ser Arg Lys Thr Asn His Lys Ser Pro 
        195                 200                 205             


Glu Ser Ile Thr Lys Cys Thr Glu Gln Trp Lys Ser Val Leu Gly Glu 
    210                 215                 220                 


<210> 7
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 7
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 8
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 8
ggcggtggag gatccggagg aggtggctcc ggcggcggag gatct                       45


<210> 9
<211> 133
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-2"

<400> 9
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210> 10
<211> 133
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-3"

<400> 10
Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp Val Asn Cys 
1               5                   10                  15      


Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu 
            20                  25                  30          


Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu 
        35                  40                  45              


Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala 
    50                  55                  60                  


Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn 
65                  70                  75                  80  


Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro 
                85                  90                  95      


Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr 
            100                 105                 110         


Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln Thr Thr Leu 
        115                 120                 125             


Ser Leu Ala Ile Phe 
    130             


<210> 11
<211> 152
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-7"

<400> 11
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210> 12
<211> 79
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-8"

<400> 12
Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys 
1               5                   10                  15      


Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu 
            20                  25                  30          


Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val 
        35                  40                  45              


Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp 
    50                  55                  60                  


Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser 
65                  70                  75                  


<210> 13
<211> 160
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-10"

<400> 13
Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210> 14
<211> 114
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-15"

<400> 14
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 15
<211> 132
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-17"

<400> 15
Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210> 16
<211> 157
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-18"

<400> 16
Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
145                 150                 155         


<210> 17
<211> 352
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="PDGF-DD"

<400> 17
Arg Asp Thr Ser Ala Thr Pro Gln Ser Ala Ser Ile Lys Ala Leu Arg 
1               5                   10                  15      


Asn Ala Asn Leu Arg Arg Asp Glu Ser Asn His Leu Thr Asp Leu Tyr 
            20                  25                  30          


Arg Arg Asp Glu Thr Ile Gln Val Lys Gly Asn Gly Tyr Val Gln Ser 
        35                  40                  45              


Pro Arg Phe Pro Asn Ser Tyr Pro Arg Asn Leu Leu Leu Thr Trp Arg 
    50                  55                  60                  


Leu His Ser Gln Glu Asn Thr Arg Ile Gln Leu Val Phe Asp Asn Gln 
65                  70                  75                  80  


Phe Gly Leu Glu Glu Ala Glu Asn Asp Ile Cys Arg Tyr Asp Phe Val 
                85                  90                  95      


Glu Val Glu Asp Ile Ser Glu Thr Ser Thr Ile Ile Arg Gly Arg Trp 
            100                 105                 110         


Cys Gly His Lys Glu Val Pro Pro Arg Ile Lys Ser Arg Thr Asn Gln 
        115                 120                 125             


Ile Lys Ile Thr Phe Lys Ser Asp Asp Tyr Phe Val Ala Lys Pro Gly 
    130                 135                 140                 


Phe Lys Ile Tyr Tyr Ser Leu Leu Glu Asp Phe Gln Pro Ala Ala Ala 
145                 150                 155                 160 


Ser Glu Thr Asn Trp Glu Ser Val Thr Ser Ser Ile Ser Gly Val Ser 
                165                 170                 175     


Tyr Asn Ser Pro Ser Val Thr Asp Pro Thr Leu Ile Ala Asp Ala Leu 
            180                 185                 190         


Asp Lys Lys Ile Ala Glu Phe Asp Thr Val Glu Asp Leu Leu Lys Tyr 
        195                 200                 205             


Phe Asn Pro Glu Ser Trp Gln Glu Asp Leu Glu Asn Met Tyr Leu Asp 
    210                 215                 220                 


Thr Pro Arg Tyr Arg Gly Arg Ser Tyr His Asp Arg Lys Ser Lys Val 
225                 230                 235                 240 


Asp Leu Asp Arg Leu Asn Asp Asp Ala Lys Arg Tyr Ser Cys Thr Pro 
                245                 250                 255     


Arg Asn Tyr Ser Val Asn Ile Arg Glu Glu Leu Lys Leu Ala Asn Val 
            260                 265                 270         


Val Phe Phe Pro Arg Cys Leu Leu Val Gln Arg Cys Gly Gly Asn Cys 
        275                 280                 285             


Gly Cys Gly Thr Val Asn Trp Arg Ser Cys Thr Cys Asn Ser Gly Lys 
    290                 295                 300                 


Thr Val Lys Lys Tyr His Glu Val Leu Gln Phe Glu Pro Gly His Ile 
305                 310                 315                 320 


Lys Arg Arg Gly Arg Ala Lys Thr Met Ala Leu Val Asp Ile Gln Leu 
                325                 330                 335     


Asp His His Glu Arg Cys Asp Cys Ile Cys Ser Ser Arg Pro Pro Arg 
            340                 345                 350         


<210> 18
<211> 248
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="SCF"

<400> 18
Glu Gly Ile Cys Arg Asn Arg Val Thr Asn Asn Val Lys Asp Val Thr 
1               5                   10                  15      


Lys Leu Val Ala Asn Leu Pro Lys Asp Tyr Met Ile Thr Leu Lys Tyr 
            20                  25                  30          


Val Pro Gly Met Asp Val Leu Pro Ser His Cys Trp Ile Ser Glu Met 
        35                  40                  45              


Val Val Gln Leu Ser Asp Ser Leu Thr Asp Leu Leu Asp Lys Phe Ser 
    50                  55                  60                  


Asn Ile Ser Glu Gly Leu Ser Asn Tyr Ser Ile Ile Asp Lys Leu Val 
65                  70                  75                  80  


Asn Ile Val Asp Asp Leu Val Glu Cys Val Lys Glu Asn Ser Ser Lys 
                85                  90                  95      


Asp Leu Lys Lys Ser Phe Lys Ser Pro Glu Pro Arg Leu Phe Thr Pro 
            100                 105                 110         


Glu Glu Phe Phe Arg Ile Phe Asn Arg Ser Ile Asp Ala Phe Lys Asp 
        115                 120                 125             


Phe Val Val Ala Ser Glu Thr Ser Asp Cys Val Val Ser Ser Thr Leu 
    130                 135                 140                 


Ser Pro Glu Lys Asp Ser Arg Val Ser Val Thr Lys Pro Phe Met Leu 
145                 150                 155                 160 


Pro Pro Val Ala Ala Ser Ser Leu Arg Asn Asp Ser Ser Ser Ser Asn 
                165                 170                 175     


Arg Lys Ala Lys Asn Pro Pro Gly Asp Ser Ser Leu His Trp Ala Ala 
            180                 185                 190         


Met Ala Leu Pro Ala Leu Phe Ser Leu Ile Ile Gly Phe Ala Phe Gly 
        195                 200                 205             


Ala Leu Tyr Trp Lys Lys Arg Gln Pro Ser Leu Thr Arg Ala Val Glu 
    210                 215                 220                 


Asn Ile Gln Ile Asn Glu Glu Asp Asn Glu Ile Ser Met Leu Gln Glu 
225                 230                 235                 240 


Lys Glu Arg Glu Phe Gln Glu Val 
                245             


<210> 19
<211> 209
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="FLT3L"

<400> 19
Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 
1               5                   10                  15      


Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 
            20                  25                  30          


Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 
        35                  40                  45              


Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 
    50                  55                  60                  


Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 
65                  70                  75                  80  


Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 
                85                  90                  95      


Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 
            100                 105                 110         


Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 
        115                 120                 125             


Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser 
    130                 135                 140                 


Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu 
145                 150                 155                 160 


Leu Leu Leu Leu Leu Leu Pro Val Gly Leu Leu Leu Leu Ala Ala Ala 
                165                 170                 175     


Trp Cys Leu His Trp Gln Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly 
            180                 185                 190         


Glu Gln Val Pro Pro Val Pro Ser Pro Gln Asp Leu Leu Leu Val Glu 
        195                 200                 205             


His 
    


<210> 20
<211> 360
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="MICA"

<400> 20
Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser Gly Lys Val Leu Val Leu Gln Ser His Trp Gln Thr Phe His 
        275                 280                 285             


Val Ser Ala Val Ala Ala Ala Ala Ile Phe Val Ile Ile Ile Phe Tyr 
    290                 295                 300                 


Val Arg Cys Cys Lys Lys Lys Thr Ser Ala Ala Glu Gly Pro Glu Leu 
305                 310                 315                 320 


Val Ser Leu Gln Val Leu Asp Gln His Pro Val Gly Thr Ser Asp His 
                325                 330                 335     


Arg Asp Ala Thr Gln Leu Gly Phe Gln Pro Leu Met Ser Asp Leu Gly 
            340                 345                 350         


Ser Thr Gly Ser Thr Glu Gly Ala 
        355                 360 


<210> 21
<211> 361
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="MICB"

<400> 21
Ala Glu Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp 
1               5                   10                  15      


Glu Ser Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Ala Glu Asp Val Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr 
    50                  55                  60                  


Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val 
                85                  90                  95      


Cys Glu Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala 
145                 150                 155                 160 


Met Gln Ala Asp Cys Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Ala Ile Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Cys Ser 
            180                 185                 190         


Glu Val Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe 
        195                 200                 205             


Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu 
    210                 215                 220                 


Ser His Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly 
225                 230                 235                 240 


Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln 
                245                 250                 255     


Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr His Pro 
            260                 265                 270         


Val Pro Ser Gly Lys Val Leu Val Leu Gln Ser Gln Arg Thr Asp Phe 
        275                 280                 285             


Pro Tyr Val Ser Ala Ala Met Pro Cys Phe Val Ile Ile Ile Ile Leu 
    290                 295                 300                 


Cys Val Pro Cys Cys Lys Lys Lys Thr Ser Ala Ala Glu Gly Pro Glu 
305                 310                 315                 320 


Leu Val Ser Leu Gln Val Leu Asp Gln His Pro Val Gly Thr Gly Asp 
                325                 330                 335     


His Arg Asp Ala Ala Gln Leu Gly Phe Gln Pro Leu Met Ser Ala Thr 
            340                 345                 350         


Gly Ser Thr Gly Ser Thr Glu Gly Ala 
        355                 360     


<210> 22
<211> 190
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="ULBP1"

<400> 22
Trp Val Asp Thr His Cys Leu Cys Tyr Asp Phe Ile Ile Thr Pro Lys 
1               5                   10                  15      


Ser Arg Pro Glu Pro Gln Trp Cys Glu Val Gln Gly Leu Val Asp Glu 
            20                  25                  30          


Arg Pro Phe Leu His Tyr Asp Cys Val Asn His Lys Ala Lys Ala Phe 
        35                  40                  45              


Ala Ser Leu Gly Lys Lys Val Asn Val Thr Lys Thr Trp Glu Glu Gln 
    50                  55                  60                  


Thr Glu Thr Leu Arg Asp Val Val Asp Phe Leu Lys Gly Gln Leu Leu 
65                  70                  75                  80  


Asp Ile Gln Val Glu Asn Leu Ile Pro Ile Glu Pro Leu Thr Leu Gln 
                85                  90                  95      


Ala Arg Met Ser Cys Glu His Glu Ala His Gly His Gly Arg Gly Ser 
            100                 105                 110         


Trp Gln Phe Leu Phe Asn Gly Gln Lys Phe Leu Leu Phe Asp Ser Asn 
        115                 120                 125             


Asn Arg Lys Trp Thr Ala Leu His Pro Gly Ala Lys Lys Met Thr Glu 
    130                 135                 140                 


Lys Trp Glu Lys Asn Arg Asp Val Thr Met Phe Phe Gln Lys Ile Ser 
145                 150                 155                 160 


Leu Gly Asp Cys Lys Met Trp Leu Glu Glu Phe Leu Met Tyr Trp Glu 
                165                 170                 175     


Gln Met Leu Asp Pro Thr Lys Pro Pro Ser Leu Ala Pro Gly 
            180                 185                 190 


<210> 23
<211> 191
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="ULBP2"

<400> 23
Gly Arg Ala Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro 
1               5                   10                  15      


Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp 
            20                  25                  30          


Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro 
        35                  40                  45              


Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala 
    50                  55                  60                  


Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu 
65                  70                  75                  80  


Arg Asp Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu 
                85                  90                  95      


Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly 
            100                 105                 110         


Ser Trp Gln Phe Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser 
        115                 120                 125             


Glu Lys Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys 
    130                 135                 140                 


Glu Lys Trp Glu Asn Asp Lys Val Val Ala Met Ser Phe His Tyr Phe 
145                 150                 155                 160 


Ser Met Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met 
                165                 170                 175     


Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Leu Ala Met Ser 
            180                 185                 190     


<210> 24
<211> 188
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="ULBP3"

<400> 24
Asp Ala His Ser Leu Trp Tyr Asn Phe Thr Ile Ile His Leu Pro Arg 
1               5                   10                  15      


His Gly Gln Gln Trp Cys Glu Val Gln Ser Gln Val Asp Gln Lys Asn 
            20                  25                  30          


Phe Leu Ser Tyr Asp Cys Gly Ser Asp Lys Val Leu Ser Met Gly His 
        35                  40                  45              


Leu Glu Glu Gln Leu Tyr Ala Thr Asp Ala Trp Gly Lys Gln Leu Glu 
    50                  55                  60                  


Met Leu Arg Glu Val Gly Gln Arg Leu Arg Leu Glu Leu Ala Asp Thr 
65                  70                  75                  80  


Glu Leu Glu Asp Phe Thr Pro Ser Gly Pro Leu Thr Leu Gln Val Arg 
                85                  90                  95      


Met Ser Cys Glu Cys Glu Ala Asp Gly Tyr Ile Arg Gly Ser Trp Gln 
            100                 105                 110         


Phe Ser Phe Asp Gly Arg Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg 
        115                 120                 125             


Lys Trp Thr Val Val His Ala Gly Ala Arg Arg Met Lys Glu Lys Trp 
    130                 135                 140                 


Glu Lys Asp Ser Gly Leu Thr Thr Phe Phe Lys Met Val Ser Met Arg 
145                 150                 155                 160 


Asp Cys Lys Ser Trp Leu Arg Asp Phe Leu Met His Arg Lys Lys Arg 
                165                 170                 175     


Leu Glu Pro Thr Ala Pro Pro Thr Met Ala Pro Gly 
            180                 185             


<210> 25
<211> 233
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="ULBP4"

<400> 25
His Ser Leu Cys Phe Asn Phe Thr Ile Lys Ser Leu Ser Arg Pro Gly 
1               5                   10                  15      


Gln Pro Trp Cys Glu Ala Gln Val Phe Leu Asn Lys Asn Leu Phe Leu 
            20                  25                  30          


Gln Tyr Asn Ser Asp Asn Asn Met Val Lys Pro Leu Gly Leu Leu Gly 
        35                  40                  45              


Lys Lys Val Tyr Ala Thr Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu 
    50                  55                  60                  


Gly Glu Val Gly Arg Asp Leu Arg Met Leu Leu Cys Asp Ile Lys Pro 
65                  70                  75                  80  


Gln Ile Lys Thr Ser Asp Pro Ser Thr Leu Gln Val Glu Met Phe Cys 
                85                  90                  95      


Gln Arg Glu Ala Glu Arg Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr 
            100                 105                 110         


Asn Gly Glu Lys Ser Leu Leu Phe Asp Ala Met Asn Met Thr Trp Thr 
        115                 120                 125             


Val Ile Asn His Glu Ala Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp 
    130                 135                 140                 


Arg Gly Leu Glu Lys Tyr Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp 
145                 150                 155                 160 


His Trp Leu Arg Glu Phe Leu Gly His Trp Glu Ala Met Pro Glu Pro 
                165                 170                 175     


Thr Val Ser Pro Val Asn Ala Ser Asp Ile His Trp Ser Ser Ser Ser 
            180                 185                 190         


Leu Pro Asp Arg Trp Ile Ile Leu Gly Ala Phe Ile Leu Leu Val Leu 
        195                 200                 205             


Met Gly Ile Val Leu Ile Cys Val Trp Trp Gln Asn Gly Glu Trp Gln 
    210                 215                 220                 


Ala Gly Leu Trp Pro Leu Arg Thr Ser 
225                 230             


<210> 26
<211> 193
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="ULBP5"

<400> 26
Gly Leu Ala Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro 
1               5                   10                  15      


Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp 
            20                  25                  30          


Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Ser Lys Thr Val Thr Pro 
        35                  40                  45              


Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Thr Ala Trp Lys Ala 
    50                  55                  60                  


Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu 
65                  70                  75                  80  


Leu Asp Ile Gln Leu Glu Asn Tyr Ile Pro Lys Glu Pro Leu Thr Leu 
                85                  90                  95      


Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Gly Ser Gly 
            100                 105                 110         


Ser Trp Gln Leu Ser Phe Asp Gly Gln Ile Phe Leu Leu Phe Asp Ser 
        115                 120                 125             


Glu Asn Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys 
    130                 135                 140                 


Glu Lys Trp Glu Asn Asp Lys Asp Met Thr Met Ser Phe His Tyr Ile 
145                 150                 155                 160 


Ser Met Gly Asp Cys Thr Gly Trp Leu Glu Asp Phe Leu Met Gly Met 
                165                 170                 175     


Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Pro Thr Met Ser Ser 
            180                 185                 190         


Gly 
    


<210> 27
<211> 193
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="ULBP6"

<400> 27
Arg Arg Asp Asp Pro His Ser Leu Cys Tyr Asp Ile Thr Val Ile Pro 
1               5                   10                  15      


Lys Phe Arg Pro Gly Pro Arg Trp Cys Ala Val Gln Gly Gln Val Asp 
            20                  25                  30          


Glu Lys Thr Phe Leu His Tyr Asp Cys Gly Asn Lys Thr Val Thr Pro 
        35                  40                  45              


Val Ser Pro Leu Gly Lys Lys Leu Asn Val Thr Met Ala Trp Lys Ala 
    50                  55                  60                  


Gln Asn Pro Val Leu Arg Glu Val Val Asp Ile Leu Thr Glu Gln Leu 
65                  70                  75                  80  


Leu Asp Ile Gln Leu Glu Asn Tyr Thr Pro Lys Glu Pro Leu Thr Leu 
                85                  90                  95      


Gln Ala Arg Met Ser Cys Glu Gln Lys Ala Glu Gly His Ser Ser Gly 
            100                 105                 110         


Ser Trp Gln Phe Ser Ile Asp Gly Gln Thr Phe Leu Leu Phe Asp Ser 
        115                 120                 125             


Glu Lys Arg Met Trp Thr Thr Val His Pro Gly Ala Arg Lys Met Lys 
    130                 135                 140                 


Glu Lys Trp Glu Asn Asp Lys Asp Val Ala Met Ser Phe His Tyr Ile 
145                 150                 155                 160 


Ser Met Gly Asp Cys Ile Gly Trp Leu Glu Asp Phe Leu Met Gly Met 
                165                 170                 175     


Asp Ser Thr Leu Glu Pro Ser Ala Gly Ala Pro Leu Ala Met Ser Ser 
            180                 185                 190         


Gly 
    


<210> 28
<211> 65
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL15Ralpha"

<400> 28
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg 
65  


<210> 29
<211> 195
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL15Ralpha"

<400> 29
attacatgcc cccctcccat gagcgtggag cacgccgaca tctgggtgaa gagctatagc       60

ctctacagcc gggagaggta tatctgtaac agcggcttca agaggaaggc cggcaccagc      120

agcctcaccg agtgcgtgct gaataaggct accaacgtgg ctcactggac aacaccctct      180

ttaaagtgca tccgg                                                       195


<210> 30
<211> 342
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-15"

<400> 30
aactgggtga acgtcatcag cgatttaaag aagatcgaag atttaattca gtccatgcat       60

atcgacgcca ctttatacac agaatccgac gtgcacccct cttgtaaggt gaccgccatg      120

aaatgttttt tactggagct gcaagttatc tctttagaga gcggagacgc tagcatccac      180

gacaccgtgg agaatttaat cattttagcc aataactctt tatccagcaa cggcaacgtg      240

acagagtccg gctgcaagga gtgcgaagag ctggaggaga agaacatcaa ggagtttctg      300

caatcctttg tgcacattgt ccagatgttc atcaatacct cc                         342


<210> 31
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210> 32
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctcc             54


<210> 33
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 33
atgaagtggg tcacatttat ctctttactg ttcctcttct ccagcgccta cagc             54


<210> 34
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 34
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctcc             54


<210> 35
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Leu Gly Val Asn Cys 
1               5                   10                  15      


<210> 36
<211> 58
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Ile Ile Thr Ser Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Leu Ala Leu Val Ser 
        35                  40                  45              


Phe Leu Phe Leu Ala Gly Arg Ser Cys Gly 
    50                  55              


<210> 37
<211> 97
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Met Pro Asn His Gln Ser Gly Ser Pro Thr Gly Ser Ser Asp Leu Leu 
1               5                   10                  15      


Leu Ser Gly Lys Lys Gln Arg Pro His Leu Ala Leu Arg Arg Lys Arg 
            20                  25                  30          


Arg Arg Glu Met Arg Lys Ile Asn Arg Lys Val Arg Arg Met Asn Leu 
        35                  40                  45              


Ala Pro Ile Lys Glu Lys Thr Ala Trp Gln His Leu Gln Ala Leu Ile 
    50                  55                  60                  


Ser Glu Ala Glu Glu Val Leu Lys Thr Ser Gln Thr Pro Gln Asn Ser 
65                  70                  75                  80  


Leu Thr Leu Phe Leu Ala Leu Leu Ser Val Leu Gly Pro Pro Val Thr 
                85                  90                  95      


Gly 
    


<210> 38
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Cys Gln Gly Val Val Ser 
            20                  25                  30  


<210> 39
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      AviTag sequence"

<400> 39
Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210> 40
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 40
Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 41
Glu Glu Glu Glu Glu Glu Thr 
1               5           


<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 42
Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 43
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 44
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 45
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 45
His His His His His 
1               5   


<210> 46
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 46
His His His His His His 
1               5       


<210> 47
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 47
His His His His His His His 
1               5           


<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 48
His His His His His His His His 
1               5               


<210> 49
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 49
His His His His His His His His His 
1               5                   


<210> 50
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 50
His His His His His His His His His His 
1               5                   10  


<210> 51
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 51
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 52
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 52
Thr Lys Glu Asn Pro Arg Ser Asn Gln Glu Glu Ser Tyr Asp Asp Asn 
1               5                   10                  15      


Glu Ser 
        


<210> 53
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 53
Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210> 54
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 54
Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210> 55
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 55
Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210> 56
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 56
Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210> 57
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 57
Pro Asp Arg Val Arg Ala Val Ser His Trp Ser Ser 
1               5                   10          


<210> 58
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 58
Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210> 59
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 59
Cys Cys Pro Gly Cys Cys 
1               5       


<210> 60
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 60
Glu Val His Thr Asn Gln Asp Pro Leu Asp 
1               5                   10  


<210> 61
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 61
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210> 62
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 62
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 63
Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210> 64
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Tag sequence"

<400> 64
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 65
<211> 471
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-18"

<400> 65
tacttcggca aactggaatc caagctgagc gtgatccgga atttaaacga ccaagttctg       60

tttatcgatc aaggtaaccg gcctctgttc gaggacatga ccgactccga ttgccgggac      120

aatgcccccc ggaccatctt cattatctcc atgtacaagg acagccagcc ccggggcatg      180

gctgtgacaa ttagcgtgaa gtgtgagaaa atcagcactt tatcttgtga gaacaagatc      240

atctccttta aggaaatgaa cccccccgat aacatcaagg acaccaagtc cgatatcatc      300

ttcttccagc ggtccgtgcc cggtcacgat aacaagatgc agttcgaatc ctcctcctac      360

gagggctact ttttagcttg tgaaaaggag agggatttat tcaagctgat cctcaagaag      420

gaggacgagc tgggcgatcg ttccatcatg ttcaccgtcc aaaacgagga t               471


<210> 66
<211> 306
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-12Beta"

<400> 66
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210> 67
<211> 918
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-12Beta"

<400> 67
atttgggaac tgaagaagga cgtctacgtg gtcgaactgg actggtatcc cgatgctccc       60

ggcgaaatgg tggtgctcac ttgtgacacc cccgaagaag acggcatcac ttggaccctc      120

gatcagagca gcgaggtgct gggctccgga aagaccctca caatccaagt taaggagttc      180

ggagacgctg gccaatacac atgccacaag ggaggcgagg tgctcagcca ttccttatta      240

ttattacaca agaaggaaga cggaatctgg tccaccgaca ttttaaaaga tcagaaggag      300

cccaagaata agaccttttt aaggtgtgag gccaaaaact acagcggtcg tttcacttgt      360

tggtggctga ccaccatttc caccgattta accttctccg tgaaaagcag ccggggaagc      420

tccgaccctc aaggtgtgac atgtggagcc gctaccctca gcgctgagag ggttcgtggc      480

gataacaagg aatacgagta cagcgtggag tgccaagaag atagcgcttg tcccgctgcc      540

gaagaatctt tacccattga ggtgatggtg gacgccgtgc acaaactcaa gtacgagaac      600

tacacctcct ccttctttat ccgggacatc attaagcccg atcctcctaa gaatttacag      660

ctgaagcctc tcaaaaatag ccggcaagtt gaggtctctt gggaatatcc cgacacttgg      720

agcacacccc acagctactt ctctttaacc ttttgtgtgc aagttcaagg taaaagcaag      780

cgggagaaga aagaccgggt gtttaccgac aaaaccagcg ccaccgtcat ctgtcggaag      840

aacgcctcca tcagcgtgag ggctcaagat cgttattact ccagcagctg gtccgagtgg      900

gccagcgtgc cttgttcc                                                    918


<210> 68
<211> 197
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-12alpha"

<400> 68
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 69
<211> 591
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-12alpha"

<400> 69
cgtaacctcc ccgtggctac ccccgatccc ggaatgttcc cttgtttaca ccacagccag       60

aatttactga gggccgtgag caacatgctg cagaaagcta ggcagacttt agaattttac      120

ccttgcacca gcgaggagat cgaccatgaa gatatcacca aggacaagac atccaccgtg      180

gaggcttgtt tacctctgga gctgacaaag aacgagtctt gtctcaactc tcgtgaaacc      240

agcttcatca caaatggctc ttgtttagct tcccggaaga cctcctttat gatggcttta      300

tgcctcagct ccatctacga ggatttaaag atgtaccaag tggagttcaa gaccatgaac      360

gccaagctgc tcatggaccc taaacggcag atctttttag accagaacat gctggctgtg      420

attgatgagc tgatgcaagc tttaaacttc aactccgaga ccgtccctca gaagtcctcc      480

ctcgaggagc ccgattttta caagacaaag atcaaactgt gcattttact ccacgccttt      540

aggatccggg ccgtgaccat tgaccgggtc atgagctatt taaacgccag c               591


<210> 70
<211> 490
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 70
Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Ser Gly Thr 
145                 150                 155                 160 


Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe 
                165                 170                 175     


Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr 
            180                 185                 190         


Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr 
        195                 200                 205             


Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val 
    210                 215                 220                 


Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val 
225                 230                 235                 240 


Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu 
                245                 250                 255     


Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser 
            260                 265                 270         


Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg 
        275                 280                 285             


Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe 
    290                 295                 300                 


Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser 
305                 310                 315                 320 


Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val 
                325                 330                 335     


Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser 
            340                 345                 350         


Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly 
        355                 360                 365             


Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp 
    370                 375                 380                 


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
385                 390                 395                 400 


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
                405                 410                 415     


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
            420                 425                 430         


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
        435                 440                 445             


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
    450                 455                 460                 


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
465                 470                 475                 480 


His Ile Val Gln Met Phe Ile Asn Thr Ser 
                485                 490 


<210> 71
<211> 1470
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 71
tacttcggca aactggaatc caagctgagc gtgatccgga atttaaacga ccaagttctg       60

tttatcgatc aaggtaaccg gcctctgttc gaggacatga ccgactccga ttgccgggac      120

aatgcccccc ggaccatctt cattatctcc atgtacaagg acagccagcc ccggggcatg      180

gctgtgacaa ttagcgtgaa gtgtgagaaa atcagcactt tatcttgtga gaacaagatc      240

atctccttta aggaaatgaa cccccccgat aacatcaagg acaccaagtc cgatatcatc      300

ttcttccagc ggtccgtgcc cggtcacgat aacaagatgc agttcgaatc ctcctcctac      360

gagggctact ttttagcttg tgaaaaggag agggatttat tcaagctgat cctcaagaag      420

gaggacgagc tgggcgatcg ttccatcatg ttcaccgtcc aaaacgagga tagcggcaca      480

accaacacag tcgctgccta taacctcact tggaagagca ccaacttcaa aaccatcctc      540

gaatgggaac ccaaacccgt taaccaagtt tacaccgtgc agatcagcac caagtccggc      600

gactggaagt ccaaatgttt ctataccacc gacaccgagt gcgatctcac cgatgagatc      660

gtgaaagatg tgaaacagac ctacctcgcc cgggtgttta gctaccccgc cggcaatgtg      720

gagagcactg gttccgctgg cgagccttta tacgagaaca gccccgaatt taccccttac      780

ctcgagacca atttaggaca gcccaccatc caaagctttg agcaagttgg cacaaaggtg      840

aatgtgacag tggaggacga gcggacttta gtgcggcgga acaacacctt tctcagcctc      900

cgggatgtgt tcggcaaaga tttaatctac acactgtatt actggaagtc ctcttcctcc      960

ggcaagaaga cagctaaaac caacacaaac gagtttttaa tcgacgtgga taaaggcgaa     1020

aactactgtt tcagcgtgca agctgtgatc ccctcccgga ccgtgaatag gaaaagcacc     1080

gatagccccg ttgagtgcat gggccaagaa aagggcgagt tccgggagaa ctgggtgaac     1140

gtcatcagcg atttaaagaa gatcgaagat ttaattcagt ccatgcatat cgacgccact     1200

ttatacacag aatccgacgt gcacccctct tgtaaggtga ccgccatgaa atgtttttta     1260

ctggagctgc aagttatctc tttagagagc ggagacgcta gcatccacga caccgtggag     1320

aatttaatca ttttagccaa taactcttta tccagcaacg gcaacgtgac agagtccggc     1380

tgcaaggagt gcgaagagct ggaggagaag aacatcaagg agtttctgca atcctttgtg     1440

cacattgtcc agatgttcat caatacctcc                                      1470


<210> 72
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 72
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn 
            20                  25                  30          


Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe 
        35                  40                  45              


Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile 
    50                  55                  60                  


Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val 
65                  70                  75                  80  


Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn 
                85                  90                  95      


Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp 
            100                 105                 110         


Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp 
        115                 120                 125             


Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala 
    130                 135                 140                 


Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp 
145                 150                 155                 160 


Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Ser 
                165                 170                 175     


Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr 
            180                 185                 190         


Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val 
        195                 200                 205             


Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys 
    210                 215                 220                 


Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
225                 230                 235                 240 


Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly 
                245                 250                 255     


Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser 
            260                 265                 270         


Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile 
        275                 280                 285             


Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp 
    290                 295                 300                 


Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp 
305                 310                 315                 320 


Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser 
                325                 330                 335     


Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile 
            340                 345                 350         


Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile 
        355                 360                 365             


Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys 
    370                 375                 380                 


Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile 
385                 390                 395                 400 


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
                405                 410                 415     


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
            420                 425                 430         


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
        435                 440                 445             


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
    450                 455                 460                 


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
465                 470                 475                 480 


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
                485                 490                 495     


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            500                 505             


<210> 73
<211> 1524
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 73
atgaagtggg tcacatttat ctctttactg ttcctcttct ccagcgccta cagctacttc       60

ggcaaactgg aatccaagct gagcgtgatc cggaatttaa acgaccaagt tctgtttatc      120

gatcaaggta accggcctct gttcgaggac atgaccgact ccgattgccg ggacaatgcc      180

ccccggacca tcttcattat ctccatgtac aaggacagcc agccccgggg catggctgtg      240

acaattagcg tgaagtgtga gaaaatcagc actttatctt gtgagaacaa gatcatctcc      300

tttaaggaaa tgaacccccc cgataacatc aaggacacca agtccgatat catcttcttc      360

cagcggtccg tgcccggtca cgataacaag atgcagttcg aatcctcctc ctacgagggc      420

tactttttag cttgtgaaaa ggagagggat ttattcaagc tgatcctcaa gaaggaggac      480

gagctgggcg atcgttccat catgttcacc gtccaaaacg aggatagcgg cacaaccaac      540

acagtcgctg cctataacct cacttggaag agcaccaact tcaaaaccat cctcgaatgg      600

gaacccaaac ccgttaacca agtttacacc gtgcagatca gcaccaagtc cggcgactgg      660

aagtccaaat gtttctatac caccgacacc gagtgcgatc tcaccgatga gatcgtgaaa      720

gatgtgaaac agacctacct cgcccgggtg tttagctacc ccgccggcaa tgtggagagc      780

actggttccg ctggcgagcc tttatacgag aacagccccg aatttacccc ttacctcgag      840

accaatttag gacagcccac catccaaagc tttgagcaag ttggcacaaa ggtgaatgtg      900

acagtggagg acgagcggac tttagtgcgg cggaacaaca cctttctcag cctccgggat      960

gtgttcggca aagatttaat ctacacactg tattactgga agtcctcttc ctccggcaag     1020

aagacagcta aaaccaacac aaacgagttt ttaatcgacg tggataaagg cgaaaactac     1080

tgtttcagcg tgcaagctgt gatcccctcc cggaccgtga ataggaaaag caccgatagc     1140

cccgttgagt gcatgggcca agaaaagggc gagttccggg agaactgggt gaacgtcatc     1200

agcgatttaa agaagatcga agatttaatt cagtccatgc atatcgacgc cactttatac     1260

acagaatccg acgtgcaccc ctcttgtaag gtgaccgcca tgaaatgttt tttactggag     1320

ctgcaagtta tctctttaga gagcggagac gctagcatcc acgacaccgt ggagaattta     1380

atcattttag ccaataactc tttatccagc aacggcaacg tgacagagtc cggctgcaag     1440

gagtgcgaag agctggagga gaagaacatc aaggagtttc tgcaatcctt tgtgcacatt     1500

gtccagatgt tcatcaatac ctcc                                            1524


<210> 74
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 74
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
        515                 520                 525             


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
    530                 535                 540                 


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
545                 550                 555                 560 


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                565                 570                 575     


Pro Ser Leu Lys Cys Ile Arg 
            580             


<210> 75
<211> 1749
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 75
atttgggaac tgaagaagga cgtctacgtg gtcgaactgg actggtatcc cgatgctccc       60

ggcgaaatgg tggtgctcac ttgtgacacc cccgaagaag acggcatcac ttggaccctc      120

gatcagagca gcgaggtgct gggctccgga aagaccctca caatccaagt taaggagttc      180

ggagacgctg gccaatacac atgccacaag ggaggcgagg tgctcagcca ttccttatta      240

ttattacaca agaaggaaga cggaatctgg tccaccgaca ttttaaaaga tcagaaggag      300

cccaagaata agaccttttt aaggtgtgag gccaaaaact acagcggtcg tttcacttgt      360

tggtggctga ccaccatttc caccgattta accttctccg tgaaaagcag ccggggaagc      420

tccgaccctc aaggtgtgac atgtggagcc gctaccctca gcgctgagag ggttcgtggc      480

gataacaagg aatacgagta cagcgtggag tgccaagaag atagcgcttg tcccgctgcc      540

gaagaatctt tacccattga ggtgatggtg gacgccgtgc acaaactcaa gtacgagaac      600

tacacctcct ccttctttat ccgggacatc attaagcccg atcctcctaa gaatttacag      660

ctgaagcctc tcaaaaatag ccggcaagtt gaggtctctt gggaatatcc cgacacttgg      720

agcacacccc acagctactt ctctttaacc ttttgtgtgc aagttcaagg taaaagcaag      780

cgggagaaga aagaccgggt gtttaccgac aaaaccagcg ccaccgtcat ctgtcggaag      840

aacgcctcca tcagcgtgag ggctcaagat cgttattact ccagcagctg gtccgagtgg      900

gccagcgtgc cttgttccgg cggtggagga tccggaggag gtggctccgg cggcggagga      960

tctcgtaacc tccccgtggc tacccccgat cccggaatgt tcccttgttt acaccacagc     1020

cagaatttac tgagggccgt gagcaacatg ctgcagaaag ctaggcagac tttagaattt     1080

tacccttgca ccagcgagga gatcgaccat gaagatatca ccaaggacaa gacatccacc     1140

gtggaggctt gtttacctct ggagctgaca aagaacgagt cttgtctcaa ctctcgtgaa     1200

accagcttca tcacaaatgg ctcttgttta gcttcccgga agacctcctt tatgatggct     1260

ttatgcctca gctccatcta cgaggattta aagatgtacc aagtggagtt caagaccatg     1320

aacgccaagc tgctcatgga ccctaaacgg cagatctttt tagaccagaa catgctggct     1380

gtgattgatg agctgatgca agctttaaac ttcaactccg agaccgtccc tcagaagtcc     1440

tccctcgagg agcccgattt ttacaagaca aagatcaaac tgtgcatttt actccacgcc     1500

tttaggatcc gggccgtgac cattgaccgg gtcatgagct atttaaacgc cagcattaca     1560

tgcccccctc ccatgagcgt ggagcacgcc gacatctggg tgaagagcta tagcctctac     1620

agccgggaga ggtatatctg taacagcggc ttcaagagga aggccggcac cagcagcctc     1680

accgagtgcg tgctgaataa ggctaccaac gtggctcact ggacaacacc ctctttaaag     1740

tgcatccgg                                                             1749


<210> 76
<211> 601
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 76
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp 
            20                  25                  30          


Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr 
        35                  40                  45              


Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val 
    50                  55                  60                  


Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp 
65                  70                  75                  80  


Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser 
                85                  90                  95      


Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile 
            100                 105                 110         


Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu 
        115                 120                 125             


Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile 
    130                 135                 140                 


Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp 
145                 150                 155                 160 


Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val 
                165                 170                 175     


Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp 
            180                 185                 190         


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val 
        195                 200                 205             


Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
    210                 215                 220                 


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
            260                 265                 270         


Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp 
        275                 280                 285             


Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val 
    290                 295                 300                 


Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
305                 310                 315                 320 


Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            340                 345                 350         


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        355                 360                 365             


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    370                 375                 380                 


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
385                 390                 395                 400 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                405                 410                 415     


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            420                 425                 430         


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
        435                 440                 445             


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    450                 455                 460                 


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
465                 470                 475                 480 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                485                 490                 495     


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            500                 505                 510         


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        515                 520                 525             


Val Met Ser Tyr Leu Asn Ala Ser Ile Thr Cys Pro Pro Pro Met Ser 
    530                 535                 540                 


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
545                 550                 555                 560 


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
                565                 570                 575     


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
            580                 585                 590         


Thr Thr Pro Ser Leu Lys Cys Ile Arg 
        595                 600     


<210> 77
<211> 1803
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s sequence"

<400> 77
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctccatttgg       60

gaactgaaga aggacgtcta cgtggtcgaa ctggactggt atcccgatgc tcccggcgaa      120

atggtggtgc tcacttgtga cacccccgaa gaagacggca tcacttggac cctcgatcag      180

agcagcgagg tgctgggctc cggaaagacc ctcacaatcc aagttaagga gttcggagac      240

gctggccaat acacatgcca caagggaggc gaggtgctca gccattcctt attattatta      300

cacaagaagg aagacggaat ctggtccacc gacattttaa aagatcagaa ggagcccaag      360

aataagacct ttttaaggtg tgaggccaaa aactacagcg gtcgtttcac ttgttggtgg      420

ctgaccacca tttccaccga tttaaccttc tccgtgaaaa gcagccgggg aagctccgac      480

cctcaaggtg tgacatgtgg agccgctacc ctcagcgctg agagggttcg tggcgataac      540

aaggaatacg agtacagcgt ggagtgccaa gaagatagcg cttgtcccgc tgccgaagaa      600

tctttaccca ttgaggtgat ggtggacgcc gtgcacaaac tcaagtacga gaactacacc      660

tcctccttct ttatccggga catcattaag cccgatcctc ctaagaattt acagctgaag      720

cctctcaaaa atagccggca agttgaggtc tcttgggaat atcccgacac ttggagcaca      780

ccccacagct acttctcttt aaccttttgt gtgcaagttc aaggtaaaag caagcgggag      840

aagaaagacc gggtgtttac cgacaaaacc agcgccaccg tcatctgtcg gaagaacgcc      900

tccatcagcg tgagggctca agatcgttat tactccagca gctggtccga gtgggccagc      960

gtgccttgtt ccggcggtgg aggatccgga ggaggtggct ccggcggcgg aggatctcgt     1020

aacctccccg tggctacccc cgatcccgga atgttccctt gtttacacca cagccagaat     1080

ttactgaggg ccgtgagcaa catgctgcag aaagctaggc agactttaga attttaccct     1140

tgcaccagcg aggagatcga ccatgaagat atcaccaagg acaagacatc caccgtggag     1200

gcttgtttac ctctggagct gacaaagaac gagtcttgtc tcaactctcg tgaaaccagc     1260

ttcatcacaa atggctcttg tttagcttcc cggaagacct cctttatgat ggctttatgc     1320

ctcagctcca tctacgagga tttaaagatg taccaagtgg agttcaagac catgaacgcc     1380

aagctgctca tggaccctaa acggcagatc tttttagacc agaacatgct ggctgtgatt     1440

gatgagctga tgcaagcttt aaacttcaac tccgagaccg tccctcagaa gtcctccctc     1500

gaggagcccg atttttacaa gacaaagatc aaactgtgca ttttactcca cgcctttagg     1560

atccgggccg tgaccattga ccgggtcatg agctatttaa acgccagcat tacatgcccc     1620

cctcccatga gcgtggagca cgccgacatc tgggtgaaga gctatagcct ctacagccgg     1680

gagaggtata tctgtaacag cggcttcaag aggaaggccg gcaccagcag cctcaccgag     1740

tgcgtgctga ataaggctac caacgtggct cactggacaa caccctcttt aaagtgcatc     1800

cgg                                                                   1803


<210> 78
<211> 133
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-21"

<400> 78
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser 
    130             


<210> 79
<211> 399
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL7RA MCP insert sequence"

<400> 79
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcc                             399


<210> 80
<211> 136
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 80
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135     


<210> 81
<211> 136
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 81
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135     


<210> 82
<211> 408
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 82
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcacgatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgat                   408


<210> 83
<211> 408
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 83
attcctcccc acgtgcagaa gagcgtgaat aatgacatga tcgtgaccga taacaatggc       60

gccgtgaaat ttccccagct gtgcaaattc tgcgatgtga ggttttccac ctgcgacaac      120

cagaagtcct gtatgagcaa ctgcacaatc acctccatct gtgagaagcc tcaggaggtg      180

tgcgtggctg tctggcggaa gaatgacgag aatatcaccc tggaaaccgt ctgccacgat      240

cccaagctgc cctaccacga tttcatcctg gaagacgccg ccagccctaa gtgcatcatg      300

aaagagaaaa agaagcctgg cgagaccttt ttcatgtgct cctgcagcag cgacgaatgc      360

aacgacaata tcatctttag cgaggaatac aataccagca accccgac                   408


<210> 84
<211> 960
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 84
aactgggtga atgtgatcag cgacctgaag aagatcgagg atctgatcca gagcatgcac       60

attgatgcca ccctgtacac agaatctgat gtgcacccta tcccccccca tgtgcaaaag      120

agcgtgaaca acgatatgat cgtgaccgac aacaacggcg ccgtgaagtt tccccagctc      180

tgcaagttct gcgatgtcag gttcagcacc tgcgataatc agaagtcctg catgtccaac      240

tgcacgatca cctccatctg cgagaagccc caagaagtgt gcgtggccgt gtggcggaaa      300

aatgacgaga acatcaccct ggagaccgtg tgtcacgacc ccaagctccc ttatcacgac      360

ttcattctgg aggacgctgc ctcccccaaa tgcatcatga aggagaagaa gaagcccgga      420

gagaccttct ttatgtgttc ctgtagcagc gacgagtgta acgacaacat catcttcagc      480

gaagagtaca acaccagcaa ccctgatgga ggtggcggat ccggaggtgg aggttctggt      540

ggaggtggga gtattcctcc ccacgtgcag aagagcgtga ataatgacat gatcgtgacc      600

gataacaatg gcgccgtgaa atttccccag ctgtgcaaat tctgcgatgt gaggttttcc      660

acctgcgaca accagaagtc ctgtatgagc aactgcacaa tcacctccat ctgtgagaag      720

cctcaggagg tgtgcgtggc tgtctggcgg aagaatgacg agaatatcac cctggaaacc      780

gtctgccacg atcccaagct gccctaccac gatttcatcc tggaagacgc cgccagccct      840

aagtgcatca tgaaagagaa aaagaagcct ggcgagacct ttttcatgtg ctcctgcagc      900

agcgacgaat gcaacgacaa tatcatcttt agcgaggaat acaataccag caaccccgac      960


<210> 85
<211> 287
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="TGFRbetaRII"

<400> 85
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
        275                 280                 285         


<210> 86
<211> 466
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 86
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn 
    130                 135                 140                 


Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro 
145                 150                 155                 160 


Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly 
                165                 170                 175     


Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu 
            180                 185                 190         


Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val 
        195                 200                 205             


Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu 
    210                 215                 220                 


Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn 
225                 230                 235                 240 


Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val 
                245                 250                 255     


Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr 
            260                 265                 270         


Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu 
        275                 280                 285             


Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn 
    290                 295                 300                 


Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe 
305                 310                 315                 320 


Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr 
                325                 330                 335     


Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
            340                 345                 350         


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
        355                 360                 365             


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
    370                 375                 380                 


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
385                 390                 395                 400 


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
                405                 410                 415     


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
            420                 425                 430         


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
        435                 440                 445             


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
    450                 455                 460                 


Thr Ser 
465     


<210> 87
<211> 1398
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 87
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcct ccggcaccac caataccgtg      420

gccgcttata acctcacatg gaagagcacc aacttcaaga caattctgga atgggaaccc      480

aagcccgtca atcaagttta caccgtgcag atctccacca aatccggaga ctggaagagc      540

aagtgcttct acacaacaga caccgagtgt gatttaaccg acgaaatcgt caaggacgtc      600

aagcaaacct atctggctcg ggtcttttcc taccccgctg gcaatgtcga gtccaccggc      660

tccgctggcg agcctctcta cgagaattcc cccgaattca ccccttattt agagaccaat      720

ttaggccagc ctaccatcca gagcttcgag caagttggca ccaaggtgaa cgtcaccgtc      780

gaggatgaaa ggactttagt gcggcggaat aacacatttt tatccctccg ggatgtgttc      840

ggcaaagacc tcatctacac actgtactat tggaagtcca gctcctccgg caaaaagacc      900

gctaagacca acaccaacga gtttttaatt gacgtggaca aaggcgagaa ctactgcttc      960

agcgtgcaag ccgtgatccc ttctcgtacc gtcaaccgga agagcacaga ttcccccgtt     1020

gagtgcatgg gccaagaaaa gggcgagttc cgggagaact gggtgaacgt catcagcgat     1080

ttaaagaaga tcgaagattt aattcagtcc atgcatatcg acgccacttt atacacagaa     1140

tccgacgtgc acccctcttg taaggtgacc gccatgaaat gttttttact ggagctgcaa     1200

gttatctctt tagagagcgg agacgctagc atccacgaca ccgtggagaa tttaatcatt     1260

ttagccaata actctttatc cagcaacggc aacgtgacag agtccggctg caaggagtgc     1320

gaagagctgg aggagaagaa catcaaggag tttctgcaat cctttgtgca cattgtccag     1380

atgttcatca atacctcc                                                   1398


<210> 88
<211> 484
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 88
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ser Gly Thr Thr Asn Thr Val Ala Ala 
145                 150                 155                 160 


Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp 
                165                 170                 175     


Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys 
            180                 185                 190         


Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys 
        195                 200                 205             


Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala 
    210                 215                 220                 


Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala 
225                 230                 235                 240 


Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu 
                245                 250                 255     


Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr 
            260                 265                 270         


Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn 
        275                 280                 285             


Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr 
    290                 295                 300                 


Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys 
305                 310                 315                 320 


Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr 
                325                 330                 335     


Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys 
            340                 345                 350         


Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe 
        355                 360                 365             


Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
    370                 375                 380                 


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
385                 390                 395                 400 


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
                405                 410                 415     


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
            420                 425                 430         


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
        435                 440                 445             


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
    450                 455                 460                 


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
465                 470                 475                 480 


Ile Asn Thr Ser 
                


<210> 89
<211> 1452
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 89
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tcctccggca ccaccaatac cgtggccgct      480

tataacctca catggaagag caccaacttc aagacaattc tggaatggga acccaagccc      540

gtcaatcaag tttacaccgt gcagatctcc accaaatccg gagactggaa gagcaagtgc      600

ttctacacaa cagacaccga gtgtgattta accgacgaaa tcgtcaagga cgtcaagcaa      660

acctatctgg ctcgggtctt ttcctacccc gctggcaatg tcgagtccac cggctccgct      720

ggcgagcctc tctacgagaa ttcccccgaa ttcacccctt atttagagac caatttaggc      780

cagcctacca tccagagctt cgagcaagtt ggcaccaagg tgaacgtcac cgtcgaggat      840

gaaaggactt tagtgcggcg gaataacaca tttttatccc tccgggatgt gttcggcaaa      900

gacctcatct acacactgta ctattggaag tccagctcct ccggcaaaaa gaccgctaag      960

accaacacca acgagttttt aattgacgtg gacaaaggcg agaactactg cttcagcgtg     1020

caagccgtga tcccttctcg taccgtcaac cggaagagca cagattcccc cgttgagtgc     1080

atgggccaag aaaagggcga gttccgggag aactgggtga acgtcatcag cgatttaaag     1140

aagatcgaag atttaattca gtccatgcat atcgacgcca ctttatacac agaatccgac     1200

gtgcacccct cttgtaaggt gaccgccatg aaatgttttt tactggagct gcaagttatc     1260

tctttagaga gcggagacgc tagcatccac gacaccgtgg agaatttaat cattttagcc     1320

aataactctt tatccagcaa cggcaacgtg acagagtccg gctgcaagga gtgcgaagag     1380

ctggaggaga agaacatcaa ggagtttctg caatcctttg tgcacattgt ccagatgttc     1440

atcaatacct cc                                                         1452


<210> 90
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 90
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile 
        275                 280                 285             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    290                 295                 300                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
305                 310                 315                 320 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                325                 330                 335     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            340                 345                 350         


<210> 91
<211> 1056
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 91
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcacgatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgcaca      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga catcacgtgt cctcctccta tgtccgtgga acacgcagac      900

atctgggtca agagctacag cttgtactcc agggagcggt acatttgtaa ctctggtttc      960

aagcgtaaag ccggcacgtc cagcctgacg gagtgcgtgt tgaacaaggc cacgaatgtc     1020

gcccactgga caacccccag tctcaaatgt attaga                               1056


<210> 92
<211> 370
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 92
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg 
    370 


<210> 93
<211> 1110
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-TGFRs sequence"

<400> 93
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcac gatcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg cacaatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacatcac gtgtcctcct cctatgtccg tggaacacgc agacatctgg      960

gtcaagagct acagcttgta ctccagggag cggtacattt gtaactctgg tttcaagcgt     1020

aaagccggca cgtccagcct gacggagtgc gtgttgaaca aggccacgaa tgtcgcccac     1080

tggacaaccc ccagtctcaa atgtattaga                                      1110


<210> 94
<211> 399
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="IL-21"

<400> 94
caaggtcaag atcgccacat gattagaatg cgtcaactta tagatattgt tgatcagctg       60

aaaaattatg tgaatgactt ggtccctgaa tttctgccag ctccagaaga tgtagagaca      120

aactgtgagt ggtcagcttt ttcctgtttt cagaaggccc aactaaagtc agcaaataca      180

ggaaacaatg aaaggataat caatgtatca attaaaaagc tgaagaggaa accaccttcc      240

acaaatgcag ggagaagaca gaaacacaga ctaacatgcc cttcatgtga ttcttatgag      300

aaaaaaccac ccaaagaatt cctagaaaga ttcaaatcac ttctccaaaa gatgattcat      360

cagcatctgt cctctagaac acacggaagt gaagattcc                             399


<210> 95
<211> 456
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL-7 sequence"

<400> 95
gattgtgata ttgaaggtaa agatggcaaa caatatgaga gtgttctaat ggtcagcatc       60

gatcaattat tggacagcat gaaagaaatt ggtagcaatt gcctgaataa tgaatttaac      120

ttttttaaaa gacatatctg tgatgctaat aaggaaggta tgtttttatt ccgtgctgct      180

cgcaagttga ggcaatttct taaaatgaat agcactggtg attttgatct ccacttatta      240

aaagtttcag aaggcacaac aatactgttg aactgcactg gccaggttaa aggaagaaaa      300

ccagctgccc tgggtgaagc ccaaccaaca aagagtttgg aagaaaataa atctttaaag      360

gaacagaaaa aactgaatga cttgtgtttc ctaaagagac tattacaaga gataaaaact      420

tgttggaata aaattttgat gggcactaaa gaacac                                456


<210> 96
<211> 466
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 96
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn 
    130                 135                 140                 


Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro 
145                 150                 155                 160 


Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly 
                165                 170                 175     


Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu 
            180                 185                 190         


Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val 
        195                 200                 205             


Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu 
    210                 215                 220                 


Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn 
225                 230                 235                 240 


Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val 
                245                 250                 255     


Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr 
            260                 265                 270         


Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu 
        275                 280                 285             


Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn 
    290                 295                 300                 


Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe 
305                 310                 315                 320 


Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr 
                325                 330                 335     


Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
            340                 345                 350         


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
        355                 360                 365             


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
    370                 375                 380                 


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
385                 390                 395                 400 


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
                405                 410                 415     


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
            420                 425                 430         


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
        435                 440                 445             


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
    450                 455                 460                 


Thr Ser 
465     


<210> 97
<211> 1398
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 97
caaggtcaag atcgccacat gattagaatg cgtcaactta tagatattgt tgatcagctg       60

aaaaattatg tgaatgactt ggtccctgaa tttctgccag ctccagaaga tgtagagaca      120

aactgtgagt ggtcagcttt ttcctgtttt cagaaggccc aactaaagtc agcaaataca      180

ggaaacaatg aaaggataat caatgtatca attaaaaagc tgaagaggaa accaccttcc      240

acaaatgcag ggagaagaca gaaacacaga ctaacatgcc cttcatgtga ttcttatgag      300

aaaaaaccac ccaaagaatt cctagaaaga ttcaaatcac ttctccaaaa gatgattcat      360

cagcatctgt cctctagaac acacggaagt gaagattcct caggcactac aaatactgtg      420

gcagcatata atttaacttg gaaatcaact aatttcaaga caattttgga gtgggaaccc      480

aaacccgtca atcaagtcta cactgttcaa ataagcacta agtcaggaga ttggaaaagc      540

aaatgctttt acacaacaga cacagagtgt gacctcaccg acgagattgt gaaggatgtg      600

aagcagacgt acttggcacg ggtcttctcc tacccggcag ggaatgtgga gagcaccggt      660

tctgctgggg agcctctgta tgagaactcc ccagagttca caccttacct ggagacaaac      720

ctcggacagc caacaattca gagttttgaa caggtgggaa caaaagtgaa tgtgaccgta      780

gaagatgaac ggactttagt cagaaggaac aacactttcc taagcctccg ggatgttttt      840

ggcaaggact taatttatac actttattat tggaaatctt caagttcagg aaagaaaaca      900

gccaaaacaa acactaatga gtttttgatt gatgtggata aaggagaaaa ctactgtttc      960

agtgttcaag cagtgattcc ctcccgaaca gttaaccgga agagtacaga cagcccggta     1020

gagtgtatgg gccaggagaa aggggaattc agagaaaact gggtgaacgt catcagcgat     1080

ttaaagaaga tcgaagattt aattcagtcc atgcatatcg acgccacttt atacacagaa     1140

tccgacgtgc acccctcttg taaggtgacc gccatgaaat gttttttact ggagctgcaa     1200

gttatctctt tagagagcgg agacgctagc atccacgaca ccgtggagaa tttaatcatt     1260

ttagccaata actctttatc cagcaacggc aacgtgacag agtccggctg caaggagtgc     1320

gaagagctgg aggagaagaa catcaaggag tttctgcaat cctttgtgca cattgtccag     1380

atgttcatca atacctcc                                                   1398


<210> 98
<211> 483
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 98
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp 
            20                  25                  30          


Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe 
        35                  40                  45              


Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe 
    50                  55                  60                  


Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn 
65                  70                  75                  80  


Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro 
                85                  90                  95      


Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser 
            100                 105                 110         


Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 
        115                 120                 125             


Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr 
    130                 135                 140                 


His Gly Ser Glu Asp Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr 
145                 150                 155                 160 


Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu 
                165                 170                 175     


Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser 
            180                 185                 190         


Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp 
        195                 200                 205             


Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg 
    210                 215                 220                 


Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly 
225                 230                 235                 240 


Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr 
                245                 250                 255     


Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys 
            260                 265                 270         


Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn 
        275                 280                 285             


Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr 
    290                 295                 300                 


Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr 
305                 310                 315                 320 


Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys 
                325                 330                 335     


Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser 
            340                 345                 350         


Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg 
        355                 360                 365             


Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
    370                 375                 380                 


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
385                 390                 395                 400 


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
                405                 410                 415     


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
            420                 425                 430         


Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
        435                 440                 445             


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
    450                 455                 460                 


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
465                 470                 475                 480 


Asn Thr Ser 
            


<210> 99
<211> 1449
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 99
atgggagtga aagttctttt tgcccttatt tgtattgctg tggccgaggc ccaaggtcaa       60

gatcgccaca tgattagaat gcgtcaactt atagatattg ttgatcagct gaaaaattat      120

gtgaatgact tggtccctga atttctgcca gctccagaag atgtagagac aaactgtgag      180

tggtcagctt tttcctgttt tcagaaggcc caactaaagt cagcaaatac aggaaacaat      240

gaaaggataa tcaatgtatc aattaaaaag ctgaagagga aaccaccttc cacaaatgca      300

gggagaagac agaaacacag actaacatgc ccttcatgtg attcttatga gaaaaaacca      360

cccaaagaat tcctagaaag attcaaatca cttctccaaa agatgattca tcagcatctg      420

tcctctagaa cacacggaag tgaagattcc tcaggcacta caaatactgt ggcagcatat      480

aatttaactt ggaaatcaac taatttcaag acaattttgg agtgggaacc caaacccgtc      540

aatcaagtct acactgttca aataagcact aagtcaggag attggaaaag caaatgcttt      600

tacacaacag acacagagtg tgacctcacc gacgagattg tgaaggatgt gaagcagacg      660

tacttggcac gggtcttctc ctacccggca gggaatgtgg agagcaccgg ttctgctggg      720

gagcctctgt atgagaactc cccagagttc acaccttacc tggagacaaa cctcggacag      780

ccaacaattc agagttttga acaggtggga acaaaagtga atgtgaccgt agaagatgaa      840

cggactttag tcagaaggaa caacactttc ctaagcctcc gggatgtttt tggcaaggac      900

ttaatttata cactttatta ttggaaatct tcaagttcag gaaagaaaac agccaaaaca      960

aacactaatg agtttttgat tgatgtggat aaaggagaaa actactgttt cagtgttcaa     1020

gcagtgattc cctcccgaac agttaaccgg aagagtacag acagcccggt agagtgtatg     1080

ggccaggaga aaggggaatt cagagaaaac tgggtgaacg tcatcagcga tttaaagaag     1140

atcgaagatt taattcagtc catgcatatc gacgccactt tatacacaga atccgacgtg     1200

cacccctctt gtaaggtgac cgccatgaaa tgttttttac tggagctgca agttatctct     1260

ttagagagcg gagacgctag catccacgac accgtggaga atttaatcat tttagccaat     1320

aactctttat ccagcaacgg caacgtgaca gagtccggct gcaaggagtg cgaagagctg     1380

gaggagaaga acatcaagga gtttctgcaa tcctttgtgc acattgtcca gatgttcatc     1440

aatacctcc                                                             1449


<210> 100
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 100
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Ile Thr Cys Pro Pro Pro Met Ser 
145                 150                 155                 160 


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
                165                 170                 175     


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
            180                 185                 190         


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
        195                 200                 205             


Thr Thr Pro Ser Leu Lys Cys Ile Arg 
    210                 215         


<210> 101
<211> 651
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 101
gattgtgata ttgaaggtaa agatggcaaa caatatgaga gtgttctaat ggtcagcatc       60

gatcaattat tggacagcat gaaagaaatt ggtagcaatt gcctgaataa tgaatttaac      120

ttttttaaaa gacatatctg tgatgctaat aaggaaggta tgtttttatt ccgtgctgct      180

cgcaagttga ggcaatttct taaaatgaat agcactggtg attttgatct ccacttatta      240

aaagtttcag aaggcacaac aatactgttg aactgcactg gccaggttaa aggaagaaaa      300

ccagctgccc tgggtgaagc ccaaccaaca aagagtttgg aagaaaataa atctttaaag      360

gaacagaaaa aactgaatga cttgtgtttc ctaaagagac tattacaaga gataaaaact      420

tgttggaata aaattttgat gggcactaaa gaacacatca cgtgccctcc ccccatgtcc      480

gtggaacacg cagacatctg ggtcaagagc tacagcttgt actccaggga gcggtacatt      540

tgtaactctg gtttcaagcg taaagccggc acgtccagcc tgacggagtg cgtgttgaac      600

aaggccacga atgtcgccca ctggacaacc cccagtctca aatgcattag a               651


<210> 102
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 102
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val 
            20                  25                  30          


Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly 
        35                  40                  45              


Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys 
    50                  55                  60                  


Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu 
65                  70                  75                  80  


Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu 
                85                  90                  95      


Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln 
            100                 105                 110         


Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys 
        115                 120                 125             


Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp 
    130                 135                 140                 


Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn 
145                 150                 155                 160 


Lys Ile Leu Met Gly Thr Lys Glu His Ile Thr Cys Pro Pro Pro Met 
                165                 170                 175     


Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser 
            180                 185                 190         


Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr 
        195                 200                 205             


Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His 
    210                 215                 220                 


Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 


<210> 103
<211> 702
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21t15-7s sequence"

<400> 103
atgggagtga aagttctttt tgcccttatt tgtattgctg tggccgaggc cgattgtgat       60

attgaaggta aagatggcaa acaatatgag agtgttctaa tggtcagcat cgatcaatta      120

ttggacagca tgaaagaaat tggtagcaat tgcctgaata atgaatttaa cttttttaaa      180

agacatatct gtgatgctaa taaggaaggt atgtttttat tccgtgctgc tcgcaagttg      240

aggcaatttc ttaaaatgaa tagcactggt gattttgatc tccacttatt aaaagtttca      300

gaaggcacaa caatactgtt gaactgcact ggccaggtta aaggaagaaa accagctgcc      360

ctgggtgaag cccaaccaac aaagagtttg gaagaaaata aatctttaaa ggaacagaaa      420

aaactgaatg acttgtgttt cctaaagaga ctattacaag agataaaaac ttgttggaat      480

aaaattttga tgggcactaa agaacacatc acgtgccctc cccccatgtc cgtggaacac      540

gcagacatct gggtcaagag ctacagcttg tactccaggg agcggtacat ttgtaactct      600

ggtttcaagc gtaaagccgg cacgtccagc ctgacggagt gcgtgttgaa caaggccacg      660

aatgtcgccc actggacaac ccccagtctc aaatgcatta ga                         702


<210> 104
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 104
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr Val Ala 
145                 150                 155                 160 


Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu 
                165                 170                 175     


Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr 
            180                 185                 190         


Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu 
        195                 200                 205             


Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu 
    210                 215                 220                 


Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser 
225                 230                 235                 240 


Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu 
                245                 250                 255     


Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly 
            260                 265                 270         


Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg 
        275                 280                 285             


Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile 
    290                 295                 300                 


Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala 
305                 310                 315                 320 


Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn 
                325                 330                 335     


Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg 
            340                 345                 350         


Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu 
        355                 360                 365             


Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
    370                 375                 380                 


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
385                 390                 395                 400 


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
                405                 410                 415     


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
            420                 425                 430         


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
        435                 440                 445             


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
    450                 455                 460                 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
465                 470                 475                 480 


Phe Ile Asn Thr Ser 
                485 


<210> 105
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 105
gattgcgaca tcgagggcaa ggacggcaag cagtacgaga gcgtgctgat ggtgtccatc       60

gaccagctgc tggacagcat gaaggagatc ggctccaact gcctcaacaa cgagttcaac      120

ttcttcaagc ggcacatctg cgacgccaac aaggagggca tgttcctgtt cagggccgcc      180

aggaaactgc ggcagttcct gaagatgaac tccaccggcg acttcgacct gcacctgctg      240

aaggtgtccg agggcaccac catcctgctg aactgcaccg gacaggtgaa gggccggaaa      300

cctgctgctc tgggagaggc ccaacccacc aagagcctgg aggagaacaa gtccctgaag      360

gagcagaaga agctgaacga cctgtgcttc ctgaagaggc tgctgcagga gatcaagacc      420

tgctggaaca agatcctgat gggcaccaag gagcatagcg gcacaaccaa cacagtcgct      480

gcctataacc tcacttggaa gagcaccaac ttcaaaacca tcctcgaatg ggaacccaaa      540

cccgttaacc aagtttacac cgtgcagatc agcaccaagt ccggcgactg gaagtccaaa      600

tgtttctata ccaccgacac cgagtgcgat ctcaccgatg agatcgtgaa agatgtgaaa      660

cagacctacc tcgcccgggt gtttagctac cccgccggca atgtggagag cactggttcc      720

gctggcgagc ctttatacga gaacagcccc gaatttaccc cttacctcga gaccaattta      780

ggacagccca ccatccaaag ctttgagcaa gttggcacaa aggtgaatgt gacagtggag      840

gacgagcgga ctttagtgcg gcggaacaac acctttctca gcctccggga tgtgttcggc      900

aaagatttaa tctacacact gtattactgg aagtcctctt cctccggcaa gaagacagct      960

aaaaccaaca caaacgagtt tttaatcgac gtggataaag gcgaaaacta ctgtttcagc     1020

gtgcaagctg tgatcccctc ccggaccgtg aataggaaaa gcaccgatag ccccgttgag     1080

tgcatgggcc aagaaaaggg cgagttccgg gagaactggg tgaacgtcat cagcgattta     1140

aagaagatcg aagatttaat tcagtccatg catatcgacg ccactttata cacagaatcc     1200

gacgtgcacc cctcttgtaa ggtgaccgcc atgaaatgtt ttttactgga gctgcaagtt     1260

atctctttag agagcggaga cgctagcatc cacgacaccg tggagaattt aatcatttta     1320

gccaataact ctttatccag caacggcaac gtgacagagt ccggctgcaa ggagtgcgaa     1380

gagctggagg agaagaacat caaggagttt ctgcaatcct ttgtgcacat tgtccagatg     1440

ttcatcaata cctcc                                                      1455


<210> 106
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 106
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
            20                  25                  30          


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
        35                  40                  45              


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
    50                  55                  60                  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
65                  70                  75                  80  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
                85                  90                  95      


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
            100                 105                 110         


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
        115                 120                 125             


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
    130                 135                 140                 


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
145                 150                 155                 160 


Asn Lys Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr 
                165                 170                 175     


Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile 
            180                 185                 190         


Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile 
        195                 200                 205             


Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp 
    210                 215                 220                 


Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr 
225                 230                 235                 240 


Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr 
                245                 250                 255     


Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro 
            260                 265                 270         


Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln 
        275                 280                 285             


Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val 
    290                 295                 300                 


Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp 
305                 310                 315                 320 


Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys 
                325                 330                 335     


Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly 
            340                 345                 350         


Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val 
        355                 360                 365             


Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys 
    370                 375                 380                 


Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
385                 390                 395                 400 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                405                 410                 415     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            420                 425                 430         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        435                 440                 445             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    450                 455                 460                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
465                 470                 475                 480 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                485                 490                 495     


Gln Met Phe Ile Asn Thr Ser 
            500             


<210> 107
<211> 1508
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 107
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccgattgc       60

gacatcgagg gcaaggacgg caagcagtac gagagcgtgc tgatggtgtc catcgaccag      120

ctgctggaca gcatgaagga gatcggctcc aactgcctca acaacgagtt caacttcttc      180

aagcggcaca tctgcgacgc caacaaggag ggcatgttcc tgttcagggc cgccaggaaa      240

ctgcggcagt tcctgaagat gaactccacc ggcgacttcg acctgcacct gctgaaggtg      300

tccgagggca ccaccatcct gctgaactgc accggacagg tgaagggccg gaaacctgct      360

gctctgggag aggcccaacc caccaagagc ctggaggaga acaagtccct gaaggagcag      420

aagaagctga acgacctgtg cttcctgaag aggctgctgc aggagatcaa gacctgctgg      480

aacaagatcc tgatgggcac caaggagcat agcggcacaa ccaacacagt cgctgcctat      540

aacctcactt ggaagagcac caacttcaaa accatcctcg aatgggaacc caaacccgtt      600

aaccaagttt acaccgtgca gatcagcacc aagtccggcg actggaagtc caaatgtttc      660

tataccaccg acaccgagtg cgatctcacc gatgagatcg tgaaagatgt gaaacagacc      720

tacctcgccc gggtgtttag ctaccccgcc ggcaatgtgg agagcactgg ttccgctggc      780

gagcctttat acgagaacag ccccgaattt accccttacc tcgagaccaa tttaggacag      840

cccaccatcc aaagctttga gcaagttggc acaaaggtga atgtgacagt ggaggacgag      900

cggactttag tgcggcggaa caacaccttt ctcagcctcc gggatgtgtt cggcaaagat      960

ttaatctaca cactgtatta ctggaagtcc tcttcctccg gcaagaagac agctaaaacc     1020

aacacaaacg agtttttaat cgacgtggat aaaggcgaaa actactgttt cagcgtgcaa     1080

gctgtgatcc cctcccggac cgtgaatagg aaaagcaccg atagccccgt tgagtgcatg     1140

ggccaagaaa agggcgagtt ccgggagaac tgggtgaacg tcatcagcga tttaaagaag     1200

atcgaagatt taattcagtc catgcatatc gacgccactt tatacacaga atccgacgtg     1260

cacccctctt gtaaggtgac cgccatgaaa tgttttttac tggagctgca agttatctct     1320

ttagagagcg gagacgctag catccacgac accgtggaga atttaatcat tttagccaat     1380

aactctttat ccagcaacgg caacgtgaca gagtccggct gcaaggagtg cgaagagctg     1440

gaggagaaga acatcaagga gtttctgcaa tcctttgtgc acattgtcca gatgttcatc     1500

aatacctc                                                              1508


<210> 108
<211> 198
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 108
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
    130                 135                 140                 


Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
145                 150                 155                 160 


Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
                165                 170                 175     


Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
            180                 185                 190         


Ser Leu Lys Cys Ile Arg 
        195             


<210> 109
<211> 594
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 109
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcca ttacatgccc ccctcccatg      420

agcgtggagc acgccgacat ctgggtgaag agctatagcc tctacagccg ggagaggtat      480

atctgtaaca gcggcttcaa gaggaaggcc ggcaccagca gcctcaccga gtgcgtgctg      540

aataaggcta ccaacgtggc tcactggaca acaccctctt taaagtgcat ccgg            594


<210> 110
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 110
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg 
    210                 215     


<210> 111
<211> 648
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s sequence"

<400> 111
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tccattacat gcccccctcc catgagcgtg      480

gagcacgccg acatctgggt gaagagctat agcctctaca gccgggagag gtatatctgt      540

aacagcggct tcaagaggaa ggccggcacc agcagcctca ccgagtgcgt gctgaataag      600

gctaccaacg tggctcactg gacaacaccc tctttaaagt gcatccgg                   648


<210> 112
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD16 LC sequence"

<400> 112
Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His 
            100                 105             


<210> 113
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD16 LC sequence"

<400> 113
tccgagctga cccaggaccc tgctgtgtcc gtggctctgg gccagaccgt gaggatcacc       60

tgccagggcg actccctgag gtcctactac gcctcctggt accagcagaa gcccggccag      120

gctcctgtgc tggtgatcta cggcaagaac aacaggccct ccggcatccc tgacaggttc      180

tccggatcct cctccggcaa caccgcctcc ctgaccatca caggcgctca ggccgaggac      240

gaggctgact actactgcaa ctccagggac tcctccggca accatgtggt gttcggcggc      300

ggcaccaagc tgaccgtggg ccat                                             324


<210> 114
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD16 HC sequence"

<400> 114
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Arg 
        115         


<210> 115
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      CD16 HC sequence"

<400> 115
gaggtgcagc tggtggagtc cggaggagga gtggtgaggc ctggaggctc cctgaggctg       60

agctgtgctg cctccggctt caccttcgac gactacggca tgtcctgggt gaggcaggct      120

cctggaaagg gcctggagtg ggtgtccggc atcaactgga acggcggatc caccggctac      180

gccgattccg tgaagggcag gttcaccatc agcagggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgag ggccgaggac accgccgtgt actactgcgc caggggcagg      300

tccctgctgt tcgactactg gggacagggc accctggtga ccgtgtccag g               351


<210> 116
<211> 490
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 116
Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Ser Gly Thr 
145                 150                 155                 160 


Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe 
                165                 170                 175     


Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr 
            180                 185                 190         


Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr 
        195                 200                 205             


Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val 
    210                 215                 220                 


Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val 
225                 230                 235                 240 


Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu 
                245                 250                 255     


Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser 
            260                 265                 270         


Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg 
        275                 280                 285             


Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe 
    290                 295                 300                 


Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser 
305                 310                 315                 320 


Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val 
                325                 330                 335     


Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser 
            340                 345                 350         


Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly 
        355                 360                 365             


Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp 
    370                 375                 380                 


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
385                 390                 395                 400 


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
                405                 410                 415     


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
            420                 425                 430         


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
        435                 440                 445             


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
    450                 455                 460                 


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
465                 470                 475                 480 


His Ile Val Gln Met Phe Ile Asn Thr Ser 
                485                 490 


<210> 117
<211> 1470
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 117
tacttcggca aactggaatc caagctgagc gtgatccgga atttaaacga ccaagttctg       60

tttatcgatc aaggtaaccg gcctctgttc gaggacatga ccgactccga ttgccgggac      120

aatgcccccc ggaccatctt cattatctcc atgtacaagg acagccagcc ccggggcatg      180

gctgtgacaa ttagcgtgaa gtgtgagaaa atcagcactt tatcttgtga gaacaagatc      240

atctccttta aggaaatgaa cccccccgat aacatcaagg acaccaagtc cgatatcatc      300

ttcttccagc ggtccgtgcc cggtcacgat aacaagatgc agttcgaatc ctcctcctac      360

gagggctact ttttagcttg tgaaaaggag agggatttat tcaagctgat cctcaagaag      420

gaggacgagc tgggcgatcg ttccatcatg ttcaccgtcc aaaacgagga tagcggcaca      480

accaacacag tcgctgccta taacctcact tggaagagca ccaacttcaa aaccatcctc      540

gaatgggaac ccaaacccgt taaccaagtt tacaccgtgc agatcagcac caagtccggc      600

gactggaagt ccaaatgttt ctataccacc gacaccgagt gcgatctcac cgatgagatc      660

gtgaaagatg tgaaacagac ctacctcgcc cgggtgttta gctaccccgc cggcaatgtg      720

gagagcactg gttccgctgg cgagccttta tacgagaaca gccccgaatt taccccttac      780

ctcgagacca atttaggaca gcccaccatc caaagctttg agcaagttgg cacaaaggtg      840

aatgtgacag tggaggacga gcggacttta gtgcggcgga acaacacctt tctcagcctc      900

cgggatgtgt tcggcaaaga tttaatctac acactgtatt actggaagtc ctcttcctcc      960

ggcaagaaga cagctaaaac caacacaaac gagtttttaa tcgacgtgga taaaggcgaa     1020

aactactgtt tcagcgtgca agctgtgatc ccctcccgga ccgtgaatag gaaaagcacc     1080

gatagccccg ttgagtgcat gggccaagaa aagggcgagt tccgggagaa ctgggtgaac     1140

gtcatcagcg atttaaagaa gatcgaagat ttaattcagt ccatgcatat cgacgccact     1200

ttatacacag aatccgacgt gcacccctct tgtaaggtga ccgccatgaa atgtttttta     1260

ctggagctgc aagttatctc tttagagagc ggagacgcta gcatccacga caccgtggag     1320

aatttaatca ttttagccaa taactcttta tccagcaacg gcaacgtgac agagtccggc     1380

tgcaaggagt gcgaagagct ggaggagaag aacatcaagg agtttctgca atcctttgtg     1440

cacattgtcc agatgttcat caatacctcc                                      1470


<210> 118
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 118
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn 
            20                  25                  30          


Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe 
        35                  40                  45              


Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile 
    50                  55                  60                  


Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val 
65                  70                  75                  80  


Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn 
                85                  90                  95      


Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp 
            100                 105                 110         


Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp 
        115                 120                 125             


Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala 
    130                 135                 140                 


Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp 
145                 150                 155                 160 


Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Ser 
                165                 170                 175     


Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr 
            180                 185                 190         


Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val 
        195                 200                 205             


Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys 
    210                 215                 220                 


Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
225                 230                 235                 240 


Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly 
                245                 250                 255     


Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser 
            260                 265                 270         


Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile 
        275                 280                 285             


Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp 
    290                 295                 300                 


Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp 
305                 310                 315                 320 


Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser 
                325                 330                 335     


Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile 
            340                 345                 350         


Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile 
        355                 360                 365             


Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys 
    370                 375                 380                 


Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile 
385                 390                 395                 400 


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
                405                 410                 415     


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
            420                 425                 430         


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
        435                 440                 445             


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
    450                 455                 460                 


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
465                 470                 475                 480 


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
                485                 490                 495     


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            500                 505             


<210> 119
<211> 1524
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 119
atgaagtggg tcacatttat ctctttactg ttcctcttct ccagcgccta cagctacttc       60

ggcaaactgg aatccaagct gagcgtgatc cggaatttaa acgaccaagt tctgtttatc      120

gatcaaggta accggcctct gttcgaggac atgaccgact ccgattgccg ggacaatgcc      180

ccccggacca tcttcattat ctccatgtac aaggacagcc agccccgggg catggctgtg      240

acaattagcg tgaagtgtga gaaaatcagc actttatctt gtgagaacaa gatcatctcc      300

tttaaggaaa tgaacccccc cgataacatc aaggacacca agtccgatat catcttcttc      360

cagcggtccg tgcccggtca cgataacaag atgcagttcg aatcctcctc ctacgagggc      420

tactttttag cttgtgaaaa ggagagggat ttattcaagc tgatcctcaa gaaggaggac      480

gagctgggcg atcgttccat catgttcacc gtccaaaacg aggatagcgg cacaaccaac      540

acagtcgctg cctataacct cacttggaag agcaccaact tcaaaaccat cctcgaatgg      600

gaacccaaac ccgttaacca agtttacacc gtgcagatca gcaccaagtc cggcgactgg      660

aagtccaaat gtttctatac caccgacacc gagtgcgatc tcaccgatga gatcgtgaaa      720

gatgtgaaac agacctacct cgcccgggtg tttagctacc ccgccggcaa tgtggagagc      780

actggttccg ctggcgagcc tttatacgag aacagccccg aatttacccc ttacctcgag      840

accaatttag gacagcccac catccaaagc tttgagcaag ttggcacaaa ggtgaatgtg      900

acagtggagg acgagcggac tttagtgcgg cggaacaaca cctttctcag cctccgggat      960

gtgttcggca aagatttaat ctacacactg tattactgga agtcctcttc ctccggcaag     1020

aagacagcta aaaccaacac aaacgagttt ttaatcgacg tggataaagg cgaaaactac     1080

tgtttcagcg tgcaagctgt gatcccctcc cggaccgtga ataggaaaag caccgatagc     1140

cccgttgagt gcatgggcca agaaaagggc gagttccggg agaactgggt gaacgtcatc     1200

agcgatttaa agaagatcga agatttaatt cagtccatgc atatcgacgc cactttatac     1260

acagaatccg acgtgcaccc ctcttgtaag gtgaccgcca tgaaatgttt tttactggag     1320

ctgcaagtta tctctttaga gagcggagac gctagcatcc acgacaccgt ggagaattta     1380

atcattttag ccaataactc tttatccagc aacggcaacg tgacagagtc cggctgcaag     1440

gagtgcgaag agctggagga gaagaacatc aaggagtttc tgcaatcctt tgtgcacatt     1500

gtccagatgt tcatcaatac ctcc                                            1524


<210> 120
<211> 823
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 120
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
        515                 520                 525             


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
    530                 535                 540                 


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
545                 550                 555                 560 


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
                565                 570                 575     


Pro Ser Leu Lys Cys Ile Arg Ser Glu Leu Thr Gln Asp Pro Ala Val 
            580                 585                 590         


Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser 
        595                 600                 605             


Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    610                 615                 620                 


Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro 
625                 630                 635                 640 


Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile 
                645                 650                 655     


Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg 
            660                 665                 670         


Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
        675                 680                 685             


Val Gly His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    690                 695                 700                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro 
705                 710                 715                 720 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
                725                 730                 735     


Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            740                 745                 750         


Trp Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp 
        755                 760                 765             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
    770                 775                 780                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
785                 790                 795                 800 


Tyr Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly 
                805                 810                 815     


Thr Leu Val Thr Val Ser Arg 
            820             


<210> 121
<211> 2469
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 121
atttgggaac tgaagaagga cgtctacgtg gtcgaactgg actggtatcc cgatgctccc       60

ggcgaaatgg tggtgctcac ttgtgacacc cccgaagaag acggcatcac ttggaccctc      120

gatcagagca gcgaggtgct gggctccgga aagaccctca caatccaagt taaggagttc      180

ggagacgctg gccaatacac atgccacaag ggaggcgagg tgctcagcca ttccttatta      240

ttattacaca agaaggaaga cggaatctgg tccaccgaca ttttaaaaga tcagaaggag      300

cccaagaata agaccttttt aaggtgtgag gccaaaaact acagcggtcg tttcacttgt      360

tggtggctga ccaccatttc caccgattta accttctccg tgaaaagcag ccggggaagc      420

tccgaccctc aaggtgtgac atgtggagcc gctaccctca gcgctgagag ggttcgtggc      480

gataacaagg aatacgagta cagcgtggag tgccaagaag atagcgcttg tcccgctgcc      540

gaagaatctt tacccattga ggtgatggtg gacgccgtgc acaaactcaa gtacgagaac      600

tacacctcct ccttctttat ccgggacatc attaagcccg atcctcctaa gaatttacag      660

ctgaagcctc tcaaaaatag ccggcaagtt gaggtctctt gggaatatcc cgacacttgg      720

agcacacccc acagctactt ctctttaacc ttttgtgtgc aagttcaagg taaaagcaag      780

cgggagaaga aagaccgggt gtttaccgac aaaaccagcg ccaccgtcat ctgtcggaag      840

aacgcctcca tcagcgtgag ggctcaagat cgttattact ccagcagctg gtccgagtgg      900

gccagcgtgc cttgttccgg cggtggagga tccggaggag gtggctccgg cggcggagga      960

tctcgtaacc tccccgtggc tacccccgat cccggaatgt tcccttgttt acaccacagc     1020

cagaatttac tgagggccgt gagcaacatg ctgcagaaag ctaggcagac tttagaattt     1080

tacccttgca ccagcgagga gatcgaccat gaagatatca ccaaggacaa gacatccacc     1140

gtggaggctt gtttacctct ggagctgaca aagaacgagt cttgtctcaa ctctcgtgaa     1200

accagcttca tcacaaatgg ctcttgttta gcttcccgga agacctcctt tatgatggct     1260

ttatgcctca gctccatcta cgaggattta aagatgtacc aagtggagtt caagaccatg     1320

aacgccaagc tgctcatgga ccctaaacgg cagatctttt tagaccagaa catgctggct     1380

gtgattgatg agctgatgca agctttaaac ttcaactccg agaccgtccc tcagaagtcc     1440

tccctcgagg agcccgattt ttacaagaca aagatcaaac tgtgcatttt actccacgcc     1500

tttaggatcc gggccgtgac cattgaccgg gtcatgagct atttaaacgc cagcattaca     1560

tgcccccctc ccatgagcgt ggagcacgcc gacatctggg tgaagagcta tagcctctac     1620

agccgggaga ggtatatctg taacagcggc ttcaagagga aggccggcac cagcagcctc     1680

accgagtgcg tgctgaataa ggctaccaac gtggctcact ggacaacacc ctctttaaag     1740

tgcatccggt ccgagctgac ccaggaccct gctgtgtccg tggctctggg ccagaccgtg     1800

aggatcacct gccagggcga ctccctgagg tcctactacg cctcctggta ccagcagaag     1860

cccggccagg ctcctgtgct ggtgatctac ggcaagaaca acaggccctc cggcatccct     1920

gacaggttct ccggatcctc ctccggcaac accgcctccc tgaccatcac aggcgctcag     1980

gccgaggacg aggctgacta ctactgcaac tccagggact cctccggcaa ccatgtggtg     2040

ttcggcggcg gcaccaagct gaccgtgggc catggcggcg gcggctccgg aggcggcggc     2100

agcggcggag gaggatccga ggtgcagctg gtggagtccg gaggaggagt ggtgaggcct     2160

ggaggctccc tgaggctgag ctgtgctgcc tccggcttca ccttcgacga ctacggcatg     2220

tcctgggtga ggcaggctcc tggaaagggc ctggagtggg tgtccggcat caactggaac     2280

ggcggatcca ccggctacgc cgattccgtg aagggcaggt tcaccatcag cagggacaac     2340

gccaagaact ccctgtacct gcagatgaac tccctgaggg ccgaggacac cgccgtgtac     2400

tactgcgcca ggggcaggtc cctgctgttc gactactggg gacagggcac cctggtgacc     2460

gtgtccagg                                                             2469


<210> 122
<211> 841
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 122
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp 
            20                  25                  30          


Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr 
        35                  40                  45              


Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val 
    50                  55                  60                  


Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp 
65                  70                  75                  80  


Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser 
                85                  90                  95      


Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile 
            100                 105                 110         


Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu 
        115                 120                 125             


Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile 
    130                 135                 140                 


Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp 
145                 150                 155                 160 


Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val 
                165                 170                 175     


Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp 
            180                 185                 190         


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val 
        195                 200                 205             


Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
    210                 215                 220                 


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
            260                 265                 270         


Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp 
        275                 280                 285             


Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val 
    290                 295                 300                 


Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
305                 310                 315                 320 


Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            340                 345                 350         


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        355                 360                 365             


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    370                 375                 380                 


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
385                 390                 395                 400 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                405                 410                 415     


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            420                 425                 430         


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
        435                 440                 445             


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    450                 455                 460                 


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
465                 470                 475                 480 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                485                 490                 495     


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            500                 505                 510         


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        515                 520                 525             


Val Met Ser Tyr Leu Asn Ala Ser Ile Thr Cys Pro Pro Pro Met Ser 
    530                 535                 540                 


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
545                 550                 555                 560 


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
                565                 570                 575     


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
            580                 585                 590         


Thr Thr Pro Ser Leu Lys Cys Ile Arg Ser Glu Leu Thr Gln Asp Pro 
        595                 600                 605             


Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly 
    610                 615                 620                 


Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
625                 630                 635                 640 


Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly 
                645                 650                 655     


Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu 
            660                 665                 670         


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn 
        675                 680                 685             


Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly Gly Gly Thr Lys 
    690                 695                 700                 


Leu Thr Val Gly His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
705                 710                 715                 720 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                725                 730                 735     


Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            740                 745                 750         


Phe Asp Asp Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
        755                 760                 765             


Leu Glu Trp Val Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr 
    770                 775                 780                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
785                 790                 795                 800 


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                805                 810                 815     


Val Tyr Tyr Cys Ala Arg Gly Arg Ser Leu Leu Phe Asp Tyr Trp Gly 
            820                 825                 830         


Gln Gly Thr Leu Val Thr Val Ser Arg 
        835                 840     


<210> 123
<211> 2523
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      18t15-12s16 sequence"

<400> 123
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctccatttgg       60

gaactgaaga aggacgtcta cgtggtcgaa ctggactggt atcccgatgc tcccggcgaa      120

atggtggtgc tcacttgtga cacccccgaa gaagacggca tcacttggac cctcgatcag      180

agcagcgagg tgctgggctc cggaaagacc ctcacaatcc aagttaagga gttcggagac      240

gctggccaat acacatgcca caagggaggc gaggtgctca gccattcctt attattatta      300

cacaagaagg aagacggaat ctggtccacc gacattttaa aagatcagaa ggagcccaag      360

aataagacct ttttaaggtg tgaggccaaa aactacagcg gtcgtttcac ttgttggtgg      420

ctgaccacca tttccaccga tttaaccttc tccgtgaaaa gcagccgggg aagctccgac      480

cctcaaggtg tgacatgtgg agccgctacc ctcagcgctg agagggttcg tggcgataac      540

aaggaatacg agtacagcgt ggagtgccaa gaagatagcg cttgtcccgc tgccgaagaa      600

tctttaccca ttgaggtgat ggtggacgcc gtgcacaaac tcaagtacga gaactacacc      660

tcctccttct ttatccggga catcattaag cccgatcctc ctaagaattt acagctgaag      720

cctctcaaaa atagccggca agttgaggtc tcttgggaat atcccgacac ttggagcaca      780

ccccacagct acttctcttt aaccttttgt gtgcaagttc aaggtaaaag caagcgggag      840

aagaaagacc gggtgtttac cgacaaaacc agcgccaccg tcatctgtcg gaagaacgcc      900

tccatcagcg tgagggctca agatcgttat tactccagca gctggtccga gtgggccagc      960

gtgccttgtt ccggcggtgg aggatccgga ggaggtggct ccggcggcgg aggatctcgt     1020

aacctccccg tggctacccc cgatcccgga atgttccctt gtttacacca cagccagaat     1080

ttactgaggg ccgtgagcaa catgctgcag aaagctaggc agactttaga attttaccct     1140

tgcaccagcg aggagatcga ccatgaagat atcaccaagg acaagacatc caccgtggag     1200

gcttgtttac ctctggagct gacaaagaac gagtcttgtc tcaactctcg tgaaaccagc     1260

ttcatcacaa atggctcttg tttagcttcc cggaagacct cctttatgat ggctttatgc     1320

ctcagctcca tctacgagga tttaaagatg taccaagtgg agttcaagac catgaacgcc     1380

aagctgctca tggaccctaa acggcagatc tttttagacc agaacatgct ggctgtgatt     1440

gatgagctga tgcaagcttt aaacttcaac tccgagaccg tccctcagaa gtcctccctc     1500

gaggagcccg atttttacaa gacaaagatc aaactgtgca ttttactcca cgcctttagg     1560

atccgggccg tgaccattga ccgggtcatg agctatttaa acgccagcat tacatgcccc     1620

cctcccatga gcgtggagca cgccgacatc tgggtgaaga gctatagcct ctacagccgg     1680

gagaggtata tctgtaacag cggcttcaag aggaaggccg gcaccagcag cctcaccgag     1740

tgcgtgctga ataaggctac caacgtggct cactggacaa caccctcttt aaagtgcatc     1800

cggtccgagc tgacccagga ccctgctgtg tccgtggctc tgggccagac cgtgaggatc     1860

acctgccagg gcgactccct gaggtcctac tacgcctcct ggtaccagca gaagcccggc     1920

caggctcctg tgctggtgat ctacggcaag aacaacaggc cctccggcat ccctgacagg     1980

ttctccggat cctcctccgg caacaccgcc tccctgacca tcacaggcgc tcaggccgag     2040

gacgaggctg actactactg caactccagg gactcctccg gcaaccatgt ggtgttcggc     2100

ggcggcacca agctgaccgt gggccatggc ggcggcggct ccggaggcgg cggcagcggc     2160

ggaggaggat ccgaggtgca gctggtggag tccggaggag gagtggtgag gcctggaggc     2220

tccctgaggc tgagctgtgc tgcctccggc ttcaccttcg acgactacgg catgtcctgg     2280

gtgaggcagg ctcctggaaa gggcctggag tgggtgtccg gcatcaactg gaacggcgga     2340

tccaccggct acgccgattc cgtgaagggc aggttcacca tcagcaggga caacgccaag     2400

aactccctgt acctgcagat gaactccctg agggccgagg acaccgccgt gtactactgc     2460

gccaggggca ggtccctgct gttcgactac tggggacagg gcaccctggt gaccgtgtcc     2520

agg                                                                   2523


<210> 124
<211> 456
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL-7 sequence"

<400> 124
gattgcgaca tcgagggcaa ggacggcaag cagtacgaga gcgtgctgat ggtgtccatc       60

gaccagctgc tggacagcat gaaggagatc ggctccaact gcctcaacaa cgagttcaac      120

ttcttcaagc ggcacatctg cgacgccaac aaggagggca tgttcctgtt cagggccgcc      180

aggaaactgc ggcagttcct gaagatgaac tccaccggcg acttcgacct gcacctgctg      240

aaggtgtccg agggcaccac catcctgctg aactgcaccg gacaggtgaa gggccggaaa      300

cctgctgctc tgggagaggc ccaacccacc aagagcctgg aggagaacaa gtccctgaag      360

gagcagaaga agctgaacga cctgtgcttc ctgaagaggc tgctgcagga gatcaagacc      420

tgctggaaca agatcctgat gggcaccaag gagcat                                456


<210> 125
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 125
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr Val Ala 
145                 150                 155                 160 


Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu 
                165                 170                 175     


Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr 
            180                 185                 190         


Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu 
        195                 200                 205             


Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu 
    210                 215                 220                 


Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser 
225                 230                 235                 240 


Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu 
                245                 250                 255     


Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly 
            260                 265                 270         


Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg 
        275                 280                 285             


Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile 
    290                 295                 300                 


Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala 
305                 310                 315                 320 


Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn 
                325                 330                 335     


Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg 
            340                 345                 350         


Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu 
        355                 360                 365             


Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
    370                 375                 380                 


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
385                 390                 395                 400 


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
                405                 410                 415     


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
            420                 425                 430         


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
        435                 440                 445             


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
    450                 455                 460                 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
465                 470                 475                 480 


Phe Ile Asn Thr Ser 
                485 


<210> 126
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 126
gattgcgaca tcgagggcaa ggacggcaag cagtacgaga gcgtgctgat ggtgtccatc       60

gaccagctgc tggacagcat gaaggagatc ggctccaact gcctcaacaa cgagttcaac      120

ttcttcaagc ggcacatctg cgacgccaac aaggagggca tgttcctgtt cagggccgcc      180

aggaaactgc ggcagttcct gaagatgaac tccaccggcg acttcgacct gcacctgctg      240

aaggtgtccg agggcaccac catcctgctg aactgcaccg gacaggtgaa gggccggaaa      300

cctgctgctc tgggagaggc ccaacccacc aagagcctgg aggagaacaa gtccctgaag      360

gagcagaaga agctgaacga cctgtgcttc ctgaagaggc tgctgcagga gatcaagacc      420

tgctggaaca agatcctgat gggcaccaag gagcatagcg gcacaaccaa cacagtcgct      480

gcctataacc tcacttggaa gagcaccaac ttcaaaacca tcctcgaatg ggaacccaaa      540

cccgttaacc aagtttacac cgtgcagatc agcaccaagt ccggcgactg gaagtccaaa      600

tgtttctata ccaccgacac cgagtgcgat ctcaccgatg agatcgtgaa agatgtgaaa      660

cagacctacc tcgcccgggt gtttagctac cccgccggca atgtggagag cactggttcc      720

gctggcgagc ctttatacga gaacagcccc gaatttaccc cttacctcga gaccaattta      780

ggacagccca ccatccaaag ctttgagcaa gttggcacaa aggtgaatgt gacagtggag      840

gacgagcgga ctttagtgcg gcggaacaac acctttctca gcctccggga tgtgttcggc      900

aaagatttaa tctacacact gtattactgg aagtcctctt cctccggcaa gaagacagct      960

aaaaccaaca caaacgagtt tttaatcgac gtggataaag gcgaaaacta ctgtttcagc     1020

gtgcaagctg tgatcccctc ccggaccgtg aataggaaaa gcaccgatag ccccgttgag     1080

tgcatgggcc aagaaaaggg cgagttccgg gagaactggg tgaacgtcat cagcgattta     1140

aagaagatcg aagatttaat tcagtccatg catatcgacg ccactttata cacagaatcc     1200

gacgtgcacc cctcttgtaa ggtgaccgcc atgaaatgtt ttttactgga gctgcaagtt     1260

atctctttag agagcggaga cgctagcatc cacgacaccg tggagaattt aatcatttta     1320

gccaataact ctttatccag caacggcaac gtgacagagt ccggctgcaa ggagtgcgaa     1380

gagctggagg agaagaacat caaggagttt ctgcaatcct ttgtgcacat tgtccagatg     1440

ttcatcaata cctcc                                                      1455


<210> 127
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 127
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
            20                  25                  30          


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
        35                  40                  45              


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
    50                  55                  60                  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
65                  70                  75                  80  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
                85                  90                  95      


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
            100                 105                 110         


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
        115                 120                 125             


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
    130                 135                 140                 


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
145                 150                 155                 160 


Asn Lys Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr 
                165                 170                 175     


Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile 
            180                 185                 190         


Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile 
        195                 200                 205             


Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp 
    210                 215                 220                 


Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr 
225                 230                 235                 240 


Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr 
                245                 250                 255     


Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro 
            260                 265                 270         


Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln 
        275                 280                 285             


Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val 
    290                 295                 300                 


Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp 
305                 310                 315                 320 


Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys 
                325                 330                 335     


Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly 
            340                 345                 350         


Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val 
        355                 360                 365             


Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys 
    370                 375                 380                 


Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
385                 390                 395                 400 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                405                 410                 415     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            420                 425                 430         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        435                 440                 445             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    450                 455                 460                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
465                 470                 475                 480 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                485                 490                 495     


Gln Met Phe Ile Asn Thr Ser 
            500             


<210> 128
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 128
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccgattgc       60

gacatcgagg gcaaggacgg caagcagtac gagagcgtgc tgatggtgtc catcgaccag      120

ctgctggaca gcatgaagga gatcggctcc aactgcctca acaacgagtt caacttcttc      180

aagcggcaca tctgcgacgc caacaaggag ggcatgttcc tgttcagggc cgccaggaaa      240

ctgcggcagt tcctgaagat gaactccacc ggcgacttcg acctgcacct gctgaaggtg      300

tccgagggca ccaccatcct gctgaactgc accggacagg tgaagggccg gaaacctgct      360

gctctgggag aggcccaacc caccaagagc ctggaggaga acaagtccct gaaggagcag      420

aagaagctga acgacctgtg cttcctgaag aggctgctgc aggagatcaa gacctgctgg      480

aacaagatcc tgatgggcac caaggagcat agcggcacaa ccaacacagt cgctgcctat      540

aacctcactt ggaagagcac caacttcaaa accatcctcg aatgggaacc caaacccgtt      600

aaccaagttt acaccgtgca gatcagcacc aagtccggcg actggaagtc caaatgtttc      660

tataccaccg acaccgagtg cgatctcacc gatgagatcg tgaaagatgt gaaacagacc      720

tacctcgccc gggtgtttag ctaccccgcc ggcaatgtgg agagcactgg ttccgctggc      780

gagcctttat acgagaacag ccccgaattt accccttacc tcgagaccaa tttaggacag      840

cccaccatcc aaagctttga gcaagttggc acaaaggtga atgtgacagt ggaggacgag      900

cggactttag tgcggcggaa caacaccttt ctcagcctcc gggatgtgtt cggcaaagat      960

ttaatctaca cactgtatta ctggaagtcc tcttcctccg gcaagaagac agctaaaacc     1020

aacacaaacg agtttttaat cgacgtggat aaaggcgaaa actactgttt cagcgtgcaa     1080

gctgtgatcc cctcccggac cgtgaatagg aaaagcaccg atagccccgt tgagtgcatg     1140

ggccaagaaa agggcgagtt ccgggagaac tgggtgaacg tcatcagcga tttaaagaag     1200

atcgaagatt taattcagtc catgcatatc gacgccactt tatacacaga atccgacgtg     1260

cacccctctt gtaaggtgac cgccatgaaa tgttttttac tggagctgca agttatctct     1320

ttagagagcg gagacgctag catccacgac accgtggaga atttaatcat tttagccaat     1380

aactctttat ccagcaacgg caacgtgaca gagtccggct gcaaggagtg cgaagagctg     1440

gaggagaaga acatcaagga gtttctgcaa tcctttgtgc acattgtcca gatgttcatc     1500

aatacctcc                                                             1509


<210> 129
<211> 438
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 129
Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp 
                165                 170                 175     


Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ser 
    210                 215                 220                 


Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg 
225                 230                 235                 240 


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
                245                 250                 255     


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            260                 265                 270         


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        275                 280                 285             


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    290                 295                 300                 


Arg Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp 
305                 310                 315                 320 


Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe 
                325                 330                 335     


Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe 
            340                 345                 350         


Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn 
        355                 360                 365             


Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro 
    370                 375                 380                 


Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser 
385                 390                 395                 400 


Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 
                405                 410                 415     


Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr 
            420                 425                 430         


His Gly Ser Glu Asp Ser 
        435             


<210> 130
<211> 1314
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 130
tccgagctga cccaggaccc tgctgtgtcc gtggctctgg gccagaccgt gaggatcacc       60

tgccagggcg actccctgag gtcctactac gcctcctggt accagcagaa gcccggccag      120

gctcctgtgc tggtgatcta cggcaagaac aacaggccct ccggcatccc tgacaggttc      180

tccggatcct cctccggcaa caccgcctcc ctgaccatca caggcgctca ggccgaggac      240

gaggctgact actactgcaa ctccagggac tcctccggca accatgtggt gttcggcggc      300

ggcaccaagc tgaccgtggg ccatggcggc ggcggctccg gaggcggcgg cagcggcgga      360

ggaggatccg aggtgcagct ggtggagtcc ggaggaggag tggtgaggcc tggaggctcc      420

ctgaggctga gctgtgctgc ctccggcttc accttcgacg actacggcat gtcctgggtg      480

aggcaggctc ctggaaaggg cctggagtgg gtgtccggca tcaactggaa cggcggatcc      540

accggctacg ccgattccgt gaagggcagg ttcaccatca gcagggacaa cgccaagaac      600

tccctgtacc tgcagatgaa ctccctgagg gccgaggaca ccgccgtgta ctactgcgcc      660

aggggcaggt ccctgctgtt cgactactgg ggacagggca ccctggtgac cgtgtccagg      720

attacatgcc cccctcccat gagcgtggag cacgccgaca tctgggtgaa gagctatagc      780

ctctacagcc gggagaggta tatctgtaac agcggcttca agaggaaggc cggcaccagc      840

agcctcaccg agtgcgtgct gaataaggct accaacgtgg ctcactggac aacaccctct      900

ttaaagtgca tccggcaggg ccaggacagg cacatgatcc ggatgaggca gctcatcgac      960

atcgtcgacc agctgaagaa ctacgtgaac gacctggtgc ccgagtttct gcctgccccc     1020

gaggacgtgg agaccaactg cgagtggtcc gccttctcct gctttcagaa ggcccagctg     1080

aagtccgcca acaccggcaa caacgagcgg atcatcaacg tgagcatcaa gaagctgaag     1140

cggaagcctc cctccacaaa cgccggcagg aggcagaagc acaggctgac ctgccccagc     1200

tgtgactcct acgagaagaa gccccccaag gagttcctgg agaggttcaa gtccctgctg     1260

cagaagatga tccatcagca cctgtcctcc aggacccacg gctccgagga ctcc           1314


<210> 131
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 131
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
            20                  25                  30          


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 
        35                  40                  45              


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
    50                  55                  60                  


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
65                  70                  75                  80  


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
                85                  90                  95      


Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn 
            100                 105                 110         


His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser 
                165                 170                 175     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile 
            180                 185                 190         


Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
225                 230                 235                 240 


Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Arg Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
            260                 265                 270         


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
        275                 280                 285             


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
    290                 295                 300                 


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
305                 310                 315                 320 


Cys Ile Arg Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu 
                325                 330                 335     


Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro 
            340                 345                 350         


Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser 
        355                 360                 365             


Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly 
    370                 375                 380                 


Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys 
385                 390                 395                 400 


Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys 
                405                 410                 415     


Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu 
            420                 425                 430         


Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser 
        435                 440                 445             


Arg Thr His Gly Ser Glu Asp Ser 
    450                 455     


<210> 132
<211> 1368
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-16s21 sequence"

<400> 132
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcctccgag       60

ctgacccagg accctgctgt gtccgtggct ctgggccaga ccgtgaggat cacctgccag      120

ggcgactccc tgaggtccta ctacgcctcc tggtaccagc agaagcccgg ccaggctcct      180

gtgctggtga tctacggcaa gaacaacagg ccctccggca tccctgacag gttctccgga      240

tcctcctccg gcaacaccgc ctccctgacc atcacaggcg ctcaggccga ggacgaggct      300

gactactact gcaactccag ggactcctcc ggcaaccatg tggtgttcgg cggcggcacc      360

aagctgaccg tgggccatgg cggcggcggc tccggaggcg gcggcagcgg cggaggagga      420

tccgaggtgc agctggtgga gtccggagga ggagtggtga ggcctggagg ctccctgagg      480

ctgagctgtg ctgcctccgg cttcaccttc gacgactacg gcatgtcctg ggtgaggcag      540

gctcctggaa agggcctgga gtgggtgtcc ggcatcaact ggaacggcgg atccaccggc      600

tacgccgatt ccgtgaaggg caggttcacc atcagcaggg acaacgccaa gaactccctg      660

tacctgcaga tgaactccct gagggccgag gacaccgccg tgtactactg cgccaggggc      720

aggtccctgc tgttcgacta ctggggacag ggcaccctgg tgaccgtgtc caggattaca      780

tgcccccctc ccatgagcgt ggagcacgcc gacatctggg tgaagagcta tagcctctac      840

agccgggaga ggtatatctg taacagcggc ttcaagagga aggccggcac cagcagcctc      900

accgagtgcg tgctgaataa ggctaccaac gtggctcact ggacaacacc ctctttaaag      960

tgcatccggc agggccagga caggcacatg atccggatga ggcagctcat cgacatcgtc     1020

gaccagctga agaactacgt gaacgacctg gtgcccgagt ttctgcctgc ccccgaggac     1080

gtggagacca actgcgagtg gtccgccttc tcctgctttc agaaggccca gctgaagtcc     1140

gccaacaccg gcaacaacga gcggatcatc aacgtgagca tcaagaagct gaagcggaag     1200

cctccctcca caaacgccgg caggaggcag aagcacaggc tgacctgccc cagctgtgac     1260

tcctacgaga agaagccccc caaggagttc ctggagaggt tcaagtccct gctgcagaag     1320

atgatccatc agcacctgtc ctccaggacc cacggctccg aggactcc                  1368


<210> 133
<211> 620
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 133
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser 
        275                 280                 285             


Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr 
    290                 295                 300                 


Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val 
305                 310                 315                 320 


Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys 
                325                 330                 335     


Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
            340                 345                 350         


Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly 
        355                 360                 365             


Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser 
    370                 375                 380                 


Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile 
385                 390                 395                 400 


Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp 
                405                 410                 415     


Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp 
            420                 425                 430         


Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser 
        435                 440                 445             


Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile 
    450                 455                 460                 


Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile 
465                 470                 475                 480 


Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys 
                485                 490                 495     


Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile 
            500                 505                 510         


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        515                 520                 525             


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    530                 535                 540                 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
545                 550                 555                 560 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                565                 570                 575     


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            580                 585                 590         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        595                 600                 605             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620 


<210> 134
<211> 1860
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 134
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cagcggcaca accaacacag tcgctgccta taacctcact      900

tggaagagca ccaacttcaa aaccatcctc gaatgggaac ccaaacccgt taaccaagtt      960

tacaccgtgc agatcagcac caagtccggc gactggaagt ccaaatgttt ctataccacc     1020

gacaccgagt gcgatctcac cgatgagatc gtgaaagatg tgaaacagac ctacctcgcc     1080

cgggtgttta gctaccccgc cggcaatgtg gagagcactg gttccgctgg cgagccttta     1140

tacgagaaca gccccgaatt taccccttac ctcgagacca atttaggaca gcccaccatc     1200

caaagctttg agcaagttgg cacaaaggtg aatgtgacag tggaggacga gcggacttta     1260

gtgcggcgga acaacacctt tctcagcctc cgggatgtgt tcggcaaaga tttaatctac     1320

acactgtatt actggaagtc ctcttcctcc ggcaagaaga cagctaaaac caacacaaac     1380

gagtttttaa tcgacgtgga taaaggcgaa aactactgtt tcagcgtgca agctgtgatc     1440

ccctcccgga ccgtgaatag gaaaagcacc gatagccccg ttgagtgcat gggccaagaa     1500

aagggcgagt tccgggagaa ctgggtgaac gtcatcagcg atttaaagaa gatcgaagat     1560

ttaattcagt ccatgcatat cgacgccact ttatacacag aatccgacgt gcacccctct     1620

tgtaaggtga ccgccatgaa atgtttttta ctggagctgc aagttatctc tttagagagc     1680

ggagacgcta gcatccacga caccgtggag aatttaatca ttttagccaa taactcttta     1740

tccagcaacg gcaacgtgac agagtccggc tgcaaggagt gcgaagagct ggaggagaag     1800

aacatcaagg agtttctgca atcctttgtg cacattgtcc agatgttcat caatacctcc     1860


<210> 135
<211> 638
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 135
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys 
305                 310                 315                 320 


Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn 
                325                 330                 335     


Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser 
            340                 345                 350         


Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile 
        355                 360                 365             


Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro 
    370                 375                 380                 


Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu 
385                 390                 395                 400 


Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro 
                405                 410                 415     


Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val 
            420                 425                 430         


Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu 
        435                 440                 445             


Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys 
    450                 455                 460                 


Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe 
465                 470                 475                 480 


Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala 
                485                 490                 495     


Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val 
            500                 505                 510         


Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn 
        515                 520                 525             


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
    530                 535                 540                 


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
545                 550                 555                 560 


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
                565                 570                 575     


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
            580                 585                 590         


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
        595                 600                 605             


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
    610                 615                 620                 


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
625                 630                 635             


<210> 136
<211> 1914
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 136
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacagcgg cacaaccaac acagtcgctg cctataacct cacttggaag      960

agcaccaact tcaaaaccat cctcgaatgg gaacccaaac ccgttaacca agtttacacc     1020

gtgcagatca gcaccaagtc cggcgactgg aagtccaaat gtttctatac caccgacacc     1080

gagtgcgatc tcaccgatga gatcgtgaaa gatgtgaaac agacctacct cgcccgggtg     1140

tttagctacc ccgccggcaa tgtggagagc actggttccg ctggcgagcc tttatacgag     1200

aacagccccg aatttacccc ttacctcgag accaatttag gacagcccac catccaaagc     1260

tttgagcaag ttggcacaaa ggtgaatgtg acagtggagg acgagcggac tttagtgcgg     1320

cggaacaaca cctttctcag cctccgggat gtgttcggca aagatttaat ctacacactg     1380

tattactgga agtcctcttc ctccggcaag aagacagcta aaaccaacac aaacgagttt     1440

ttaatcgacg tggataaagg cgaaaactac tgtttcagcg tgcaagctgt gatcccctcc     1500

cggaccgtga ataggaaaag caccgatagc cccgttgagt gcatgggcca agaaaagggc     1560

gagttccggg agaactgggt gaacgtcatc agcgatttaa agaagatcga agatttaatt     1620

cagtccatgc atatcgacgc cactttatac acagaatccg acgtgcaccc ctcttgtaag     1680

gtgaccgcca tgaaatgttt tttactggag ctgcaagtta tctctttaga gagcggagac     1740

gctagcatcc acgacaccgt ggagaattta atcattttag ccaataactc tttatccagc     1800

aacggcaacg tgacagagtc cggctgcaag gagtgcgaag agctggagga gaagaacatc     1860

aaggagtttc tgcaatcctt tgtgcacatt gtccagatgt tcatcaatac ctcc           1914


<210> 137
<211> 438
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 137
Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp 
                165                 170                 175     


Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ser 
    210                 215                 220                 


Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg 
225                 230                 235                 240 


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
                245                 250                 255     


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            260                 265                 270         


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        275                 280                 285             


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    290                 295                 300                 


Arg Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp 
305                 310                 315                 320 


Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe 
                325                 330                 335     


Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe 
            340                 345                 350         


Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn 
        355                 360                 365             


Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro 
    370                 375                 380                 


Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser 
385                 390                 395                 400 


Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 
                405                 410                 415     


Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr 
            420                 425                 430         


His Gly Ser Glu Asp Ser 
        435             


<210> 138
<211> 1314
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 138
tccgagctga cccaggaccc tgctgtgtcc gtggctctgg gccagaccgt gaggatcacc       60

tgccagggcg actccctgag gtcctactac gcctcctggt accagcagaa gcccggccag      120

gctcctgtgc tggtgatcta cggcaagaac aacaggccct ccggcatccc tgacaggttc      180

tccggatcct cctccggcaa caccgcctcc ctgaccatca caggcgctca ggccgaggac      240

gaggctgact actactgcaa ctccagggac tcctccggca accatgtggt gttcggcggc      300

ggcaccaagc tgaccgtggg ccatggcggc ggcggctccg gaggcggcgg cagcggcgga      360

ggaggatccg aggtgcagct ggtggagtcc ggaggaggag tggtgaggcc tggaggctcc      420

ctgaggctga gctgtgctgc ctccggcttc accttcgacg actacggcat gtcctgggtg      480

aggcaggctc ctggaaaggg cctggagtgg gtgtccggca tcaactggaa cggcggatcc      540

accggctacg ccgattccgt gaagggcagg ttcaccatca gcagggacaa cgccaagaac      600

tccctgtacc tgcagatgaa ctccctgagg gccgaggaca ccgccgtgta ctactgcgcc      660

aggggcaggt ccctgctgtt cgactactgg ggacagggca ccctggtgac cgtgtccagg      720

attacatgcc cccctcccat gagcgtggag cacgccgaca tctgggtgaa gagctatagc      780

ctctacagcc gggagaggta tatctgtaac agcggcttca agaggaaggc cggcaccagc      840

agcctcaccg agtgcgtgct gaataaggct accaacgtgg ctcactggac aacaccctct      900

ttaaagtgca tccggcaggg ccaggacagg cacatgatcc ggatgaggca gctcatcgac      960

atcgtcgacc agctgaagaa ctacgtgaac gacctggtgc ccgagtttct gcctgccccc     1020

gaggacgtgg agaccaactg cgagtggtcc gccttctcct gctttcagaa ggcccagctg     1080

aagtccgcca acaccggcaa caacgagcgg atcatcaacg tgagcatcaa gaagctgaag     1140

cggaagcctc cctccacaaa cgccggcagg aggcagaagc acaggctgac ctgccccagc     1200

tgtgactcct acgagaagaa gccccccaag gagttcctgg agaggttcaa gtccctgctg     1260

cagaagatga tccatcagca cctgtcctcc aggacccacg gctccgagga ctcc           1314


<210> 139
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 139
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
            20                  25                  30          


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 
        35                  40                  45              


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
    50                  55                  60                  


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
65                  70                  75                  80  


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
                85                  90                  95      


Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn 
            100                 105                 110         


His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser 
                165                 170                 175     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile 
            180                 185                 190         


Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
225                 230                 235                 240 


Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Arg Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
            260                 265                 270         


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
        275                 280                 285             


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
    290                 295                 300                 


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
305                 310                 315                 320 


Cys Ile Arg Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu 
                325                 330                 335     


Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro 
            340                 345                 350         


Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser 
        355                 360                 365             


Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly 
    370                 375                 380                 


Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys 
385                 390                 395                 400 


Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys 
                405                 410                 415     


Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu 
            420                 425                 430         


Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser 
        435                 440                 445             


Arg Thr His Gly Ser Glu Asp Ser 
    450                 455     


<210> 140
<211> 1368
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-16s21 sequence"

<400> 140
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcctccgag       60

ctgacccagg accctgctgt gtccgtggct ctgggccaga ccgtgaggat cacctgccag      120

ggcgactccc tgaggtccta ctacgcctcc tggtaccagc agaagcccgg ccaggctcct      180

gtgctggtga tctacggcaa gaacaacagg ccctccggca tccctgacag gttctccgga      240

tcctcctccg gcaacaccgc ctccctgacc atcacaggcg ctcaggccga ggacgaggct      300

gactactact gcaactccag ggactcctcc ggcaaccatg tggtgttcgg cggcggcacc      360

aagctgaccg tgggccatgg cggcggcggc tccggaggcg gcggcagcgg cggaggagga      420

tccgaggtgc agctggtgga gtccggagga ggagtggtga ggcctggagg ctccctgagg      480

ctgagctgtg ctgcctccgg cttcaccttc gacgactacg gcatgtcctg ggtgaggcag      540

gctcctggaa agggcctgga gtgggtgtcc ggcatcaact ggaacggcgg atccaccggc      600

tacgccgatt ccgtgaaggg caggttcacc atcagcaggg acaacgccaa gaactccctg      660

tacctgcaga tgaactccct gagggccgag gacaccgccg tgtactactg cgccaggggc      720

aggtccctgc tgttcgacta ctggggacag ggcaccctgg tgaccgtgtc caggattaca      780

tgcccccctc ccatgagcgt ggagcacgcc gacatctggg tgaagagcta tagcctctac      840

agccgggaga ggtatatctg taacagcggc ttcaagagga aggccggcac cagcagcctc      900

accgagtgcg tgctgaataa ggctaccaac gtggctcact ggacaacacc ctctttaaag      960

tgcatccggc agggccagga caggcacatg atccggatga ggcagctcat cgacatcgtc     1020

gaccagctga agaactacgt gaacgacctg gtgcccgagt ttctgcctgc ccccgaggac     1080

gtggagacca actgcgagtg gtccgccttc tcctgctttc agaaggccca gctgaagtcc     1140

gccaacaccg gcaacaacga gcggatcatc aacgtgagca tcaagaagct gaagcggaag     1200

cctccctcca caaacgccgg caggaggcag aagcacaggc tgacctgccc cagctgtgac     1260

tcctacgaga agaagccccc caaggagttc ctggagaggt tcaagtccct gctgcagaag     1320

atgatccatc agcacctgtc ctccaggacc cacggctccg aggactcc                  1368


<210> 141
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-7s sequence"

<400> 141
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr Val Ala 
145                 150                 155                 160 


Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu 
                165                 170                 175     


Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr 
            180                 185                 190         


Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu 
        195                 200                 205             


Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu 
    210                 215                 220                 


Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser 
225                 230                 235                 240 


Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu 
                245                 250                 255     


Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly 
            260                 265                 270         


Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg 
        275                 280                 285             


Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile 
    290                 295                 300                 


Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala 
305                 310                 315                 320 


Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn 
                325                 330                 335     


Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg 
            340                 345                 350         


Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu 
        355                 360                 365             


Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
    370                 375                 380                 


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
385                 390                 395                 400 


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
                405                 410                 415     


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
            420                 425                 430         


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
        435                 440                 445             


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
    450                 455                 460                 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
465                 470                 475                 480 


Phe Ile Asn Thr Ser 
                485 


<210> 142
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-7s sequence"

<400> 142
gattgcgaca tcgagggcaa ggacggcaag cagtacgaga gcgtgctgat ggtgtccatc       60

gaccagctgc tggacagcat gaaggagatc ggctccaact gcctcaacaa cgagttcaac      120

ttcttcaagc ggcacatctg cgacgccaac aaggagggca tgttcctgtt cagggccgcc      180

aggaaactgc ggcagttcct gaagatgaac tccaccggcg acttcgacct gcacctgctg      240

aaggtgtccg agggcaccac catcctgctg aactgcaccg gacaggtgaa gggccggaaa      300

cctgctgctc tgggagaggc ccaacccacc aagagcctgg aggagaacaa gtccctgaag      360

gagcagaaga agctgaacga cctgtgcttc ctgaagaggc tgctgcagga gatcaagacc      420

tgctggaaca agatcctgat gggcaccaag gagcatagcg gcacaaccaa cacagtcgct      480

gcctataacc tcacttggaa gagcaccaac ttcaaaacca tcctcgaatg ggaacccaaa      540

cccgttaacc aagtttacac cgtgcagatc agcaccaagt ccggcgactg gaagtccaaa      600

tgtttctata ccaccgacac cgagtgcgat ctcaccgatg agatcgtgaa agatgtgaaa      660

cagacctacc tcgcccgggt gtttagctac cccgccggca atgtggagag cactggttcc      720

gctggcgagc ctttatacga gaacagcccc gaatttaccc cttacctcga gaccaattta      780

ggacagccca ccatccaaag ctttgagcaa gttggcacaa aggtgaatgt gacagtggag      840

gacgagcgga ctttagtgcg gcggaacaac acctttctca gcctccggga tgtgttcggc      900

aaagatttaa tctacacact gtattactgg aagtcctctt cctccggcaa gaagacagct      960

aaaaccaaca caaacgagtt tttaatcgac gtggataaag gcgaaaacta ctgtttcagc     1020

gtgcaagctg tgatcccctc ccggaccgtg aataggaaaa gcaccgatag ccccgttgag     1080

tgcatgggcc aagaaaaggg cgagttccgg gagaactggg tgaacgtcat cagcgattta     1140

aagaagatcg aagatttaat tcagtccatg catatcgacg ccactttata cacagaatcc     1200

gacgtgcacc cctcttgtaa ggtgaccgcc atgaaatgtt ttttactgga gctgcaagtt     1260

atctctttag agagcggaga cgctagcatc cacgacaccg tggagaattt aatcatttta     1320

gccaataact ctttatccag caacggcaac gtgacagagt ccggctgcaa ggagtgcgaa     1380

gagctggagg agaagaacat caaggagttt ctgcaatcct ttgtgcacat tgtccagatg     1440

ttcatcaata cctcc                                                      1455


<210> 143
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-7s sequence"

<400> 143
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
            20                  25                  30          


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
        35                  40                  45              


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
    50                  55                  60                  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
65                  70                  75                  80  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
                85                  90                  95      


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
            100                 105                 110         


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
        115                 120                 125             


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
    130                 135                 140                 


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
145                 150                 155                 160 


Asn Lys Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr 
                165                 170                 175     


Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile 
            180                 185                 190         


Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile 
        195                 200                 205             


Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp 
    210                 215                 220                 


Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr 
225                 230                 235                 240 


Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr 
                245                 250                 255     


Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro 
            260                 265                 270         


Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln 
        275                 280                 285             


Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val 
    290                 295                 300                 


Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp 
305                 310                 315                 320 


Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys 
                325                 330                 335     


Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly 
            340                 345                 350         


Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val 
        355                 360                 365             


Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys 
    370                 375                 380                 


Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
385                 390                 395                 400 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                405                 410                 415     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            420                 425                 430         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        435                 440                 445             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    450                 455                 460                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
465                 470                 475                 480 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                485                 490                 495     


Gln Met Phe Ile Asn Thr Ser 
            500             


<210> 144
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 144
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccgattgc       60

gacatcgagg gcaaggacgg caagcagtac gagagcgtgc tgatggtgtc catcgaccag      120

ctgctggaca gcatgaagga gatcggctcc aactgcctca acaacgagtt caacttcttc      180

aagcggcaca tctgcgacgc caacaaggag ggcatgttcc tgttcagggc cgccaggaaa      240

ctgcggcagt tcctgaagat gaactccacc ggcgacttcg acctgcacct gctgaaggtg      300

tccgagggca ccaccatcct gctgaactgc accggacagg tgaagggccg gaaacctgct      360

gctctgggag aggcccaacc caccaagagc ctggaggaga acaagtccct gaaggagcag      420

aagaagctga acgacctgtg cttcctgaag aggctgctgc aggagatcaa gacctgctgg      480

aacaagatcc tgatgggcac caaggagcat agcggcacaa ccaacacagt cgctgcctat      540

aacctcactt ggaagagcac caacttcaaa accatcctcg aatgggaacc caaacccgtt      600

aaccaagttt acaccgtgca gatcagcacc aagtccggcg actggaagtc caaatgtttc      660

tataccaccg acaccgagtg cgatctcacc gatgagatcg tgaaagatgt gaaacagacc      720

tacctcgccc gggtgtttag ctaccccgcc ggcaatgtgg agagcactgg ttccgctggc      780

gagcctttat acgagaacag ccccgaattt accccttacc tcgagaccaa tttaggacag      840

cccaccatcc aaagctttga gcaagttggc acaaaggtga atgtgacagt ggaggacgag      900

cggactttag tgcggcggaa caacaccttt ctcagcctcc gggatgtgtt cggcaaagat      960

ttaatctaca cactgtatta ctggaagtcc tcttcctccg gcaagaagac agctaaaacc     1020

aacacaaacg agtttttaat cgacgtggat aaaggcgaaa actactgttt cagcgtgcaa     1080

gctgtgatcc cctcccggac cgtgaatagg aaaagcaccg atagccccgt tgagtgcatg     1140

ggccaagaaa agggcgagtt ccgggagaac tgggtgaacg tcatcagcga tttaaagaag     1200

atcgaagatt taattcagtc catgcatatc gacgccactt tatacacaga atccgacgtg     1260

cacccctctt gtaaggtgac cgccatgaaa tgttttttac tggagctgca agttatctct     1320

ttagagagcg gagacgctag catccacgac accgtggaga atttaatcat tttagccaat     1380

aactctttat ccagcaacgg caacgtgaca gagtccggct gcaaggagtg cgaagagctg     1440

gaggagaaga acatcaagga gtttctgcaa tcctttgtgc acattgtcca gatgttcatc     1500

aatacctcc                                                             1509


<210> 145
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-7s sequence"

<400> 145
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Ile Thr Cys Pro Pro Pro Met Ser 
145                 150                 155                 160 


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
                165                 170                 175     


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
            180                 185                 190         


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
        195                 200                 205             


Thr Thr Pro Ser Leu Lys Cys Ile Arg 
    210                 215         


<210> 146
<211> 651
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-7s sequence"

<400> 146
gattgtgata ttgaaggtaa agatggcaaa caatatgaga gtgttctaat ggtcagcatc       60

gatcaattat tggacagcat gaaagaaatt ggtagcaatt gcctgaataa tgaatttaac      120

ttttttaaaa gacatatctg tgatgctaat aaggaaggta tgtttttatt ccgtgctgct      180

cgcaagttga ggcaatttct taaaatgaat agcactggtg attttgatct ccacttatta      240

aaagtttcag aaggcacaac aatactgttg aactgcactg gccaggttaa aggaagaaaa      300

ccagctgccc tgggtgaagc ccaaccaaca aagagtttgg aagaaaataa atctttaaag      360

gaacagaaaa aactgaatga cttgtgtttc ctaaagagac tattacaaga gataaaaact      420

tgttggaata aaattttgat gggcactaaa gaacacatca cgtgccctcc ccccatgtcc      480

gtggaacacg cagacatctg ggtcaagagc tacagcttgt actccaggga gcggtacatt      540

tgtaactctg gtttcaagcg taaagccggc acgtccagcc tgacggagtg cgtgttgaac      600

aaggccacga atgtcgccca ctggacaacc cccagtctca aatgcattag a               651


<210> 147
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-7s sequence"

<400> 147
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
            20                  25                  30          


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
        35                  40                  45              


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
    50                  55                  60                  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
65                  70                  75                  80  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
                85                  90                  95      


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
            100                 105                 110         


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
        115                 120                 125             


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
    130                 135                 140                 


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
145                 150                 155                 160 


Asn Lys Ile Leu Met Gly Thr Lys Glu His Ile Thr Cys Pro Pro Pro 
                165                 170                 175     


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
            180                 185                 190         


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
        195                 200                 205             


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
    210                 215                 220                 


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235 


<210> 148
<211> 705
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-7s sequence"

<400> 148
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccgattgc       60

gacatcgagg gcaaggacgg caagcagtac gagagcgtgc tgatggtgtc catcgaccag      120

ctgctggaca gcatgaagga gatcggctcc aactgcctca acaacgagtt caacttcttc      180

aagcggcaca tctgcgacgc caacaaggag ggcatgttcc tgttcagggc cgccaggaaa      240

ctgcggcagt tcctgaagat gaactccacc ggcgacttcg acctgcacct gctgaaggtg      300

tccgagggca ccaccatcct gctgaactgc accggacagg tgaagggccg gaaacctgct      360

gctctgggag aggcccaacc caccaagagc ctggaggaga acaagtccct gaaggagcag      420

aagaagctga acgacctgtg cttcctgaag aggctgctgc aggagatcaa gacctgctgg      480

aacaagatcc tgatgggcac caaggagcat attacatgcc cccctcccat gagcgtggag      540

cacgccgaca tctgggtgaa gagctatagc ctctacagcc gggagaggta tatctgtaac      600

agcggcttca agaggaaggc cggcaccagc agcctcaccg agtgcgtgct gaataaggct      660

accaacgtgg ctcactggac aacaccctct ttaaagtgca tccgg                      705


<210> 149
<211> 620
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFR sequence"

<400> 149
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser 
        275                 280                 285             


Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr 
    290                 295                 300                 


Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val 
305                 310                 315                 320 


Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys 
                325                 330                 335     


Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
            340                 345                 350         


Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly 
        355                 360                 365             


Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser 
    370                 375                 380                 


Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile 
385                 390                 395                 400 


Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp 
                405                 410                 415     


Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp 
            420                 425                 430         


Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser 
        435                 440                 445             


Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile 
    450                 455                 460                 


Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile 
465                 470                 475                 480 


Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys 
                485                 490                 495     


Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile 
            500                 505                 510         


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        515                 520                 525             


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    530                 535                 540                 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
545                 550                 555                 560 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                565                 570                 575     


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            580                 585                 590         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        595                 600                 605             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620 


<210> 150
<211> 1860
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFR sequence"

<400> 150
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cagcggcaca accaacacag tcgctgccta taacctcact      900

tggaagagca ccaacttcaa aaccatcctc gaatgggaac ccaaacccgt taaccaagtt      960

tacaccgtgc agatcagcac caagtccggc gactggaagt ccaaatgttt ctataccacc     1020

gacaccgagt gcgatctcac cgatgagatc gtgaaagatg tgaaacagac ctacctcgcc     1080

cgggtgttta gctaccccgc cggcaatgtg gagagcactg gttccgctgg cgagccttta     1140

tacgagaaca gccccgaatt taccccttac ctcgagacca atttaggaca gcccaccatc     1200

caaagctttg agcaagttgg cacaaaggtg aatgtgacag tggaggacga gcggacttta     1260

gtgcggcgga acaacacctt tctcagcctc cgggatgtgt tcggcaaaga tttaatctac     1320

acactgtatt actggaagtc ctcttcctcc ggcaagaaga cagctaaaac caacacaaac     1380

gagtttttaa tcgacgtgga taaaggcgaa aactactgtt tcagcgtgca agctgtgatc     1440

ccctcccgga ccgtgaatag gaaaagcacc gatagccccg ttgagtgcat gggccaagaa     1500

aagggcgagt tccgggagaa ctgggtgaac gtcatcagcg atttaaagaa gatcgaagat     1560

ttaattcagt ccatgcatat cgacgccact ttatacacag aatccgacgt gcacccctct     1620

tgtaaggtga ccgccatgaa atgtttttta ctggagctgc aagttatctc tttagagagc     1680

ggagacgcta gcatccacga caccgtggag aatttaatca ttttagccaa taactcttta     1740

tccagcaacg gcaacgtgac agagtccggc tgcaaggagt gcgaagagct ggaggagaag     1800

aacatcaagg agtttctgca atcctttgtg cacattgtcc agatgttcat caatacctcc     1860


<210> 151
<211> 638
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFR sequence"

<400> 151
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys 
305                 310                 315                 320 


Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn 
                325                 330                 335     


Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser 
            340                 345                 350         


Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile 
        355                 360                 365             


Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro 
    370                 375                 380                 


Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu 
385                 390                 395                 400 


Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro 
                405                 410                 415     


Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val 
            420                 425                 430         


Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu 
        435                 440                 445             


Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys 
    450                 455                 460                 


Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe 
465                 470                 475                 480 


Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala 
                485                 490                 495     


Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val 
            500                 505                 510         


Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn 
        515                 520                 525             


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
    530                 535                 540                 


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
545                 550                 555                 560 


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
                565                 570                 575     


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
            580                 585                 590         


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
        595                 600                 605             


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
    610                 615                 620                 


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
625                 630                 635             


<210> 152
<211> 1914
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFR sequence"

<400> 152
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacagcgg cacaaccaac acagtcgctg cctataacct cacttggaag      960

agcaccaact tcaaaaccat cctcgaatgg gaacccaaac ccgttaacca agtttacacc     1020

gtgcagatca gcaccaagtc cggcgactgg aagtccaaat gtttctatac caccgacacc     1080

gagtgcgatc tcaccgatga gatcgtgaaa gatgtgaaac agacctacct cgcccgggtg     1140

tttagctacc ccgccggcaa tgtggagagc actggttccg ctggcgagcc tttatacgag     1200

aacagccccg aatttacccc ttacctcgag accaatttag gacagcccac catccaaagc     1260

tttgagcaag ttggcacaaa ggtgaatgtg acagtggagg acgagcggac tttagtgcgg     1320

cggaacaaca cctttctcag cctccgggat gtgttcggca aagatttaat ctacacactg     1380

tattactgga agtcctcttc ctccggcaag aagacagcta aaaccaacac aaacgagttt     1440

ttaatcgacg tggataaagg cgaaaactac tgtttcagcg tgcaagctgt gatcccctcc     1500

cggaccgtga ataggaaaag caccgatagc cccgttgagt gcatgggcca agaaaagggc     1560

gagttccggg agaactgggt gaacgtcatc agcgatttaa agaagatcga agatttaatt     1620

cagtccatgc atatcgacgc cactttatac acagaatccg acgtgcaccc ctcttgtaag     1680

gtgaccgcca tgaaatgttt tttactggag ctgcaagtta tctctttaga gagcggagac     1740

gctagcatcc acgacaccgt ggagaattta atcattttag ccaataactc tttatccagc     1800

aacggcaacg tgacagagtc cggctgcaag gagtgcgaag agctggagga gaagaacatc     1860

aaggagtttc tgcaatcctt tgtgcacatt gtccagatgt tcatcaatac ctcc           1914


<210> 153
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFR sequence"

<400> 153
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile 
        275                 280                 285             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    290                 295                 300                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
305                 310                 315                 320 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                325                 330                 335     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            340                 345                 350         


<210> 154
<211> 1056
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFR sequence"

<400> 154
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cattacatgc ccccctccca tgagcgtgga gcacgccgac      900

atctgggtga agagctatag cctctacagc cgggagaggt atatctgtaa cagcggcttc      960

aagaggaagg ccggcaccag cagcctcacc gagtgcgtgc tgaataaggc taccaacgtg     1020

gctcactgga caacaccctc tttaaagtgc atccgg                               1056


<210> 155
<211> 370
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFR sequence"

<400> 155
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg 
    370 


<210> 156
<211> 1110
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFR sequence"

<400> 156
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacattac atgcccccct cccatgagcg tggagcacgc cgacatctgg      960

gtgaagagct atagcctcta cagccgggag aggtatatct gtaacagcgg cttcaagagg     1020

aaggccggca ccagcagcct caccgagtgc gtgctgaata aggctaccaa cgtggctcac     1080

tggacaacac cctctttaaa gtgcatccgg                                      1110


<210> 157
<211> 184
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD137L"

<400> 157
Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 


<210> 158
<211> 552
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD137L"

<400> 158
cgcgagggtc ccgagctttc gcccgacgat cccgccggcc tcttggacct gcggcagggc       60

atgtttgcgc agctggtggc ccaaaatgtt ctgctgatcg atgggcccct gagctggtac      120

agtgacccag gcctggcagg cgtgtccctg acggggggcc tgagctacaa agaggacacg      180

aaggagctgg tggtggccaa ggctggagtc tactatgtct tctttcaact agagctgcgg      240

cgcgtggtgg ccggcgaggg ctcaggctcc gtttcacttg cgctgcacct gcagccactg      300

cgctctgctg ctggggccgc cgccctggct ttgaccgtgg acctgccacc cgcctcctcc      360

gaggctcgga actcggcctt cggtttccag ggccgcttgc tgcacctgag tgccggccag      420

cgcctgggcg tccatcttca cactgaggcc agggcacgcc atgcctggca gcttacccag      480

ggcgccacag tcttgggact cttccgggtg acccccgaaa tcccagccgg actcccttca      540

ccgaggtcgg aa                                                          552


<210> 159
<211> 165
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD137L"

<400> 159
Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile 
                165 


<210> 160
<211> 495
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="CD137L"

<400> 160
gatcccgccg gcctcttgga cctgcggcag ggcatgtttg cgcagctggt ggcccaaaat       60

gttctgctga tcgatgggcc cctgagctgg tacagtgacc caggcctggc aggcgtgtcc      120

ctgacggggg gcctgagcta caaagaggac acgaaggagc tggtggtggc caaggctgga      180

gtctactatg tcttctttca actagagctg cggcgcgtgg tggccggcga gggctcaggc      240

tccgtttcac ttgcgctgca cctgcagcca ctgcgctctg ctgctggggc cgccgccctg      300

gctttgaccg tggacctgcc acccgcctcc tccgaggctc ggaactcggc cttcggtttc      360

cagggccgct tgctgcacct gagtgccggc cagcgcctgg gcgtccatct tcacactgag      420

gccagggcac gccatgcctg gcagcttacc cagggcgcca cagtcttggg actcttccgg      480

gtgacccccg aaatc                                                       495


<210> 161
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 161
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr Val Ala 
145                 150                 155                 160 


Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu 
                165                 170                 175     


Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr 
            180                 185                 190         


Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu 
        195                 200                 205             


Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu 
    210                 215                 220                 


Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser 
225                 230                 235                 240 


Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu 
                245                 250                 255     


Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly 
            260                 265                 270         


Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg 
        275                 280                 285             


Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile 
    290                 295                 300                 


Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala 
305                 310                 315                 320 


Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn 
                325                 330                 335     


Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg 
            340                 345                 350         


Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu 
        355                 360                 365             


Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
    370                 375                 380                 


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
385                 390                 395                 400 


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
                405                 410                 415     


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
            420                 425                 430         


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
        435                 440                 445             


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
    450                 455                 460                 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
465                 470                 475                 480 


Phe Ile Asn Thr Ser 
                485 


<210> 162
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 162
gattgcgaca tcgagggcaa ggacggcaag cagtacgaga gcgtgctgat ggtgtccatc       60

gaccagctgc tggacagcat gaaggagatc ggctccaact gcctcaacaa cgagttcaac      120

ttcttcaagc ggcacatctg cgacgccaac aaggagggca tgttcctgtt cagggccgcc      180

aggaaactgc ggcagttcct gaagatgaac tccaccggcg acttcgacct gcacctgctg      240

aaggtgtccg agggcaccac catcctgctg aactgcaccg gacaggtgaa gggccggaaa      300

cctgctgctc tgggagaggc ccaacccacc aagagcctgg aggagaacaa gtccctgaag      360

gagcagaaga agctgaacga cctgtgcttc ctgaagaggc tgctgcagga gatcaagacc      420

tgctggaaca agatcctgat gggcaccaag gagcatagcg gcacaaccaa cacagtcgct      480

gcctataacc tcacttggaa gagcaccaac ttcaaaacca tcctcgaatg ggaacccaaa      540

cccgttaacc aagtttacac cgtgcagatc agcaccaagt ccggcgactg gaagtccaaa      600

tgtttctata ccaccgacac cgagtgcgat ctcaccgatg agatcgtgaa agatgtgaaa      660

cagacctacc tcgcccgggt gtttagctac cccgccggca atgtggagag cactggttcc      720

gctggcgagc ctttatacga gaacagcccc gaatttaccc cttacctcga gaccaattta      780

ggacagccca ccatccaaag ctttgagcaa gttggcacaa aggtgaatgt gacagtggag      840

gacgagcgga ctttagtgcg gcggaacaac acctttctca gcctccggga tgtgttcggc      900

aaagatttaa tctacacact gtattactgg aagtcctctt cctccggcaa gaagacagct      960

aaaaccaaca caaacgagtt tttaatcgac gtggataaag gcgaaaacta ctgtttcagc     1020

gtgcaagctg tgatcccctc ccggaccgtg aataggaaaa gcaccgatag ccccgttgag     1080

tgcatgggcc aagaaaaggg cgagttccgg gagaactggg tgaacgtcat cagcgattta     1140

aagaagatcg aagatttaat tcagtccatg catatcgacg ccactttata cacagaatcc     1200

gacgtgcacc cctcttgtaa ggtgaccgcc atgaaatgtt ttttactgga gctgcaagtt     1260

atctctttag agagcggaga cgctagcatc cacgacaccg tggagaattt aatcatttta     1320

gccaataact ctttatccag caacggcaac gtgacagagt ccggctgcaa ggagtgcgaa     1380

gagctggagg agaagaacat caaggagttt ctgcaatcct ttgtgcacat tgtccagatg     1440

ttcatcaata cctcc                                                      1455


<210> 163
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 163
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
            20                  25                  30          


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
        35                  40                  45              


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
    50                  55                  60                  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
65                  70                  75                  80  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
                85                  90                  95      


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
            100                 105                 110         


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
        115                 120                 125             


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
    130                 135                 140                 


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
145                 150                 155                 160 


Asn Lys Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr 
                165                 170                 175     


Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile 
            180                 185                 190         


Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile 
        195                 200                 205             


Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp 
    210                 215                 220                 


Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr 
225                 230                 235                 240 


Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr 
                245                 250                 255     


Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro 
            260                 265                 270         


Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln 
        275                 280                 285             


Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val 
    290                 295                 300                 


Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp 
305                 310                 315                 320 


Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys 
                325                 330                 335     


Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly 
            340                 345                 350         


Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val 
        355                 360                 365             


Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys 
    370                 375                 380                 


Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
385                 390                 395                 400 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                405                 410                 415     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            420                 425                 430         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        435                 440                 445             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    450                 455                 460                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
465                 470                 475                 480 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                485                 490                 495     


Gln Met Phe Ile Asn Thr Ser 
            500             


<210> 164
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 164
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccgattgc       60

gacatcgagg gcaaggacgg caagcagtac gagagcgtgc tgatggtgtc catcgaccag      120

ctgctggaca gcatgaagga gatcggctcc aactgcctca acaacgagtt caacttcttc      180

aagcggcaca tctgcgacgc caacaaggag ggcatgttcc tgttcagggc cgccaggaaa      240

ctgcggcagt tcctgaagat gaactccacc ggcgacttcg acctgcacct gctgaaggtg      300

tccgagggca ccaccatcct gctgaactgc accggacagg tgaagggccg gaaacctgct      360

gctctgggag aggcccaacc caccaagagc ctggaggaga acaagtccct gaaggagcag      420

aagaagctga acgacctgtg cttcctgaag aggctgctgc aggagatcaa gacctgctgg      480

aacaagatcc tgatgggcac caaggagcat agcggcacaa ccaacacagt cgctgcctat      540

aacctcactt ggaagagcac caacttcaaa accatcctcg aatgggaacc caaacccgtt      600

aaccaagttt acaccgtgca gatcagcacc aagtccggcg actggaagtc caaatgtttc      660

tataccaccg acaccgagtg cgatctcacc gatgagatcg tgaaagatgt gaaacagacc      720

tacctcgccc gggtgtttag ctaccccgcc ggcaatgtgg agagcactgg ttccgctggc      780

gagcctttat acgagaacag ccccgaattt accccttacc tcgagaccaa tttaggacag      840

cccaccatcc aaagctttga gcaagttggc acaaaggtga atgtgacagt ggaggacgag      900

cggactttag tgcggcggaa caacaccttt ctcagcctcc gggatgtgtt cggcaaagat      960

ttaatctaca cactgtatta ctggaagtcc tcttcctccg gcaagaagac agctaaaacc     1020

aacacaaacg agtttttaat cgacgtggat aaaggcgaaa actactgttt cagcgtgcaa     1080

gctgtgatcc cctcccggac cgtgaatagg aaaagcaccg atagccccgt tgagtgcatg     1140

ggccaagaaa agggcgagtt ccgggagaac tgggtgaacg tcatcagcga tttaaagaag     1200

atcgaagatt taattcagtc catgcatatc gacgccactt tatacacaga atccgacgtg     1260

cacccctctt gtaaggtgac cgccatgaaa tgttttttac tggagctgca agttatctct     1320

ttagagagcg gagacgctag catccacgac accgtggaga atttaatcat tttagccaat     1380

aactctttat ccagcaacgg caacgtgaca gagtccggct gcaaggagtg cgaagagctg     1440

gaggagaaga acatcaagga gtttctgcaa tcctttgtgc acattgtcca gatgttcatc     1500

aatacctcc                                                             1509


<210> 165
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 165
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
    130                 135                 140                 


Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
145                 150                 155                 160 


Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
                165                 170                 175     


Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
            180                 185                 190         


Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
    210                 215                 220                 


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
225                 230                 235                 240 


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
                245                 250                 255     


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
            260                 265                 270         


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
        275                 280                 285             


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
    290                 295                 300                 


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
305                 310                 315                 320 


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
                325                 330                 335     


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
            340                 345                 350         


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
        355                 360                 365             


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
    370                 375                 380                 


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
385                 390                 395         


<210> 166
<211> 1191
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 166
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcca ttacatgccc ccctcccatg      420

agcgtggagc acgccgacat ctgggtgaag agctatagcc tctacagccg ggagaggtat      480

atctgtaaca gcggcttcaa gaggaaggcc ggcaccagca gcctcaccga gtgcgtgctg      540

aataaggcta ccaacgtggc tcactggaca acaccctctt taaagtgcat ccggggcggt      600

ggaggatccg gaggaggtgg ctccggcggc ggaggatctc gcgagggtcc cgagctttcg      660

cccgacgatc ccgccggcct cttggacctg cggcagggca tgtttgcgca gctggtggcc      720

caaaatgttc tgctgatcga tgggcccctg agctggtaca gtgacccagg cctggcaggc      780

gtgtccctga cggggggcct gagctacaaa gaggacacga aggagctggt ggtggccaag      840

gctggagtct actatgtctt ctttcaacta gagctgcggc gcgtggtggc cggcgagggc      900

tcaggctccg tttcacttgc gctgcacctg cagccactgc gctctgctgc tggggccgcc      960

gccctggctt tgaccgtgga cctgccaccc gcctcctccg aggctcggaa ctcggccttc     1020

ggtttccagg gccgcttgct gcacctgagt gccggccagc gcctgggcgt ccatcttcac     1080

actgaggcca gggcacgcca tgcctggcag cttacccagg gcgccacagt cttgggactc     1140

ttccgggtga cccccgaaat cccagccgga ctcccttcac cgaggtcgga a              1191


<210> 167
<211> 415
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 167
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp 
225                 230                 235                 240 


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                245                 250                 255     


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            260                 265                 270         


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        275                 280                 285             


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    290                 295                 300                 


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
305                 310                 315                 320 


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                325                 330                 335     


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            340                 345                 350         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        355                 360                 365             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    370                 375                 380                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
385                 390                 395                 400 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                405                 410                 415 


<210> 168
<211> 1245
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 168
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tccattacat gcccccctcc catgagcgtg      480

gagcacgccg acatctgggt gaagagctat agcctctaca gccgggagag gtatatctgt      540

aacagcggct tcaagaggaa ggccggcacc agcagcctca ccgagtgcgt gctgaataag      600

gctaccaacg tggctcactg gacaacaccc tctttaaagt gcatccgggg cggtggagga      660

tccggaggag gtggctccgg cggcggagga tctcgcgagg gtcccgagct ttcgcccgac      720

gatcccgccg gcctcttgga cctgcggcag ggcatgtttg cgcagctggt ggcccaaaat      780

gttctgctga tcgatgggcc cctgagctgg tacagtgacc caggcctggc aggcgtgtcc      840

ctgacggggg gcctgagcta caaagaggac acgaaggagc tggtggtggc caaggctgga      900

gtctactatg tcttctttca actagagctg cggcgcgtgg tggccggcga gggctcaggc      960

tccgtttcac ttgcgctgca cctgcagcca ctgcgctctg ctgctggggc cgccgccctg     1020

gctttgaccg tggacctgcc acccgcctcc tccgaggctc ggaactcggc cttcggtttc     1080

cagggccgct tgctgcacct gagtgccggc cagcgcctgg gcgtccatct tcacactgag     1140

gccagggcac gccatgcctg gcagcttacc cagggcgcca cagtcttggg actcttccgg     1200

gtgacccccg aaatcccagc cggactccct tcaccgaggt cggaa                     1245


<210> 169
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 169
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
    130                 135                 140                 


Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
145                 150                 155                 160 


Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
                165                 170                 175     


Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
            180                 185                 190         


Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
    210                 215                 220                 


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
225                 230                 235                 240 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
                245                 250                 255     


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
            260                 265                 270         


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
        275                 280                 285             


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
    290                 295                 300                 


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
305                 310                 315                 320 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
                325                 330                 335     


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
            340                 345                 350         


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
        355                 360                 365             


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
    370                 375             


<210> 170
<211> 1134
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 170
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcca ttacatgccc ccctcccatg      420

agcgtggagc acgccgacat ctgggtgaag agctatagcc tctacagccg ggagaggtat      480

atctgtaaca gcggcttcaa gaggaaggcc ggcaccagca gcctcaccga gtgcgtgctg      540

aataaggcta ccaacgtggc tcactggaca acaccctctt taaagtgcat ccggggcggt      600

ggaggatccg gaggaggtgg ctccggcggc ggaggatctg atcccgccgg cctcttggac      660

ctgcggcagg gcatgtttgc gcagctggtg gcccaaaatg ttctgctgat cgatgggccc      720

ctgagctggt acagtgaccc aggcctggca ggcgtgtccc tgacgggggg cctgagctac      780

aaagaggaca cgaaggagct ggtggtggcc aaggctggag tctactatgt cttctttcaa      840

ctagagctgc ggcgcgtggt ggccggcgag ggctcaggct ccgtttcact tgcgctgcac      900

ctgcagccac tgcgctctgc tgctggggcc gccgccctgg ctttgaccgt ggacctgcca      960

cccgcctcct ccgaggctcg gaactcggcc ttcggtttcc agggccgctt gctgcacctg     1020

agtgccggcc agcgcctggg cgtccatctt cacactgagg ccagggcacg ccatgcctgg     1080

cagcttaccc agggcgccac agtcttggga ctcttccggg tgacccccga aatc           1134


<210> 171
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 171
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg 
225                 230                 235                 240 


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                245                 250                 255     


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            260                 265                 270         


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        275                 280                 285             


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    290                 295                 300                 


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
305                 310                 315                 320 


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                325                 330                 335     


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            340                 345                 350         


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        355                 360                 365             


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    370                 375                 380                 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
385                 390                 395     


<210> 172
<211> 1188
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-21s137L sequence"

<400> 172
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tccattacat gcccccctcc catgagcgtg      480

gagcacgccg acatctgggt gaagagctat agcctctaca gccgggagag gtatatctgt      540

aacagcggct tcaagaggaa ggccggcacc agcagcctca ccgagtgcgt gctgaataag      600

gctaccaacg tggctcactg gacaacaccc tctttaaagt gcatccgggg cggtggagga      660

tccggaggag gtggctccgg cggcggagga tctgatcccg ccggcctctt ggacctgcgg      720

cagggcatgt ttgcgcagct ggtggcccaa aatgttctgc tgatcgatgg gcccctgagc      780

tggtacagtg acccaggcct ggcaggcgtg tccctgacgg ggggcctgag ctacaaagag      840

gacacgaagg agctggtggt ggccaaggct ggagtctact atgtcttctt tcaactagag      900

ctgcggcgcg tggtggccgg cgagggctca ggctccgttt cacttgcgct gcacctgcag      960

ccactgcgct ctgctgctgg ggccgccgcc ctggctttga ccgtggacct gccacccgcc     1020

tcctccgagg ctcggaactc ggccttcggt ttccagggcc gcttgctgca cctgagtgcc     1080

ggccagcgcc tgggcgtcca tcttcacact gaggccaggg cacgccatgc ctggcagctt     1140

acccagggcg ccacagtctt gggactcttc cgggtgaccc ccgaaatc                  1188


<210> 173
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-TGFRs sequence"

<400> 173
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr Val Ala 
145                 150                 155                 160 


Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu 
                165                 170                 175     


Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr 
            180                 185                 190         


Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu 
        195                 200                 205             


Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu 
    210                 215                 220                 


Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser 
225                 230                 235                 240 


Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu 
                245                 250                 255     


Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly 
            260                 265                 270         


Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg 
        275                 280                 285             


Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile 
    290                 295                 300                 


Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala 
305                 310                 315                 320 


Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn 
                325                 330                 335     


Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg 
            340                 345                 350         


Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu 
        355                 360                 365             


Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
    370                 375                 380                 


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
385                 390                 395                 400 


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
                405                 410                 415     


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
            420                 425                 430         


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
        435                 440                 445             


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
    450                 455                 460                 


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
465                 470                 475                 480 


Phe Ile Asn Thr Ser 
                485 


<210> 174
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-TGFRs sequence"

<400> 174
gattgcgaca tcgagggcaa ggacggcaag cagtacgaga gcgtgctgat ggtgtccatc       60

gaccagctgc tggacagcat gaaggagatc ggctccaact gcctcaacaa cgagttcaac      120

ttcttcaagc ggcacatctg cgacgccaac aaggagggca tgttcctgtt cagggccgcc      180

aggaaactgc ggcagttcct gaagatgaac tccaccggcg acttcgacct gcacctgctg      240

aaggtgtccg agggcaccac catcctgctg aactgcaccg gacaggtgaa gggccggaaa      300

cctgctgctc tgggagaggc ccaacccacc aagagcctgg aggagaacaa gtccctgaag      360

gagcagaaga agctgaacga cctgtgcttc ctgaagaggc tgctgcagga gatcaagacc      420

tgctggaaca agatcctgat gggcaccaag gagcatagcg gcacaaccaa cacagtcgct      480

gcctataacc tcacttggaa gagcaccaac ttcaaaacca tcctcgaatg ggaacccaaa      540

cccgttaacc aagtttacac cgtgcagatc agcaccaagt ccggcgactg gaagtccaaa      600

tgtttctata ccaccgacac cgagtgcgat ctcaccgatg agatcgtgaa agatgtgaaa      660

cagacctacc tcgcccgggt gtttagctac cccgccggca atgtggagag cactggttcc      720

gctggcgagc ctttatacga gaacagcccc gaatttaccc cttacctcga gaccaattta      780

ggacagccca ccatccaaag ctttgagcaa gttggcacaa aggtgaatgt gacagtggag      840

gacgagcgga ctttagtgcg gcggaacaac acctttctca gcctccggga tgtgttcggc      900

aaagatttaa tctacacact gtattactgg aagtcctctt cctccggcaa gaagacagct      960

aaaaccaaca caaacgagtt tttaatcgac gtggataaag gcgaaaacta ctgtttcagc     1020

gtgcaagctg tgatcccctc ccggaccgtg aataggaaaa gcaccgatag ccccgttgag     1080

tgcatgggcc aagaaaaggg cgagttccgg gagaactggg tgaacgtcat cagcgattta     1140

aagaagatcg aagatttaat tcagtccatg catatcgacg ccactttata cacagaatcc     1200

gacgtgcacc cctcttgtaa ggtgaccgcc atgaaatgtt ttttactgga gctgcaagtt     1260

atctctttag agagcggaga cgctagcatc cacgacaccg tggagaattt aatcatttta     1320

gccaataact ctttatccag caacggcaac gtgacagagt ccggctgcaa ggagtgcgaa     1380

gagctggagg agaagaacat caaggagttt ctgcaatcct ttgtgcacat tgtccagatg     1440

ttcatcaata cctcc                                                      1455


<210> 175
<211> 502
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-TGFRs sequence"

<400> 175
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
            20                  25                  30          


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
        35                  40                  45              


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
    50                  55                  60                  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
65                  70                  75                  80  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
                85                  90                  95      


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
            100                 105                 110         


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
        115                 120                 125             


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
    130                 135                 140                 


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
145                 150                 155                 160 


Asn Lys Ile Leu Met Gly Thr Lys Glu His Ser Gly Thr Thr Asn Thr 
                165                 170                 175     


Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile 
            180                 185                 190         


Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile 
        195                 200                 205             


Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp 
    210                 215                 220                 


Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr 
225                 230                 235                 240 


Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr 
                245                 250                 255     


Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro 
            260                 265                 270         


Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln 
        275                 280                 285             


Val Gly Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val 
    290                 295                 300                 


Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp 
305                 310                 315                 320 


Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys 
                325                 330                 335     


Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly 
            340                 345                 350         


Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val 
        355                 360                 365             


Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys 
    370                 375                 380                 


Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
385                 390                 395                 400 


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
                405                 410                 415     


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
            420                 425                 430         


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
        435                 440                 445             


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
    450                 455                 460                 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
465                 470                 475                 480 


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
                485                 490                 495     


Gln Met Phe Ile Asn Thr 
            500         


<210> 176
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-TGFRs sequence"

<400> 176
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccgattgc       60

gacatcgagg gcaaggacgg caagcagtac gagagcgtgc tgatggtgtc catcgaccag      120

ctgctggaca gcatgaagga gatcggctcc aactgcctca acaacgagtt caacttcttc      180

aagcggcaca tctgcgacgc caacaaggag ggcatgttcc tgttcagggc cgccaggaaa      240

ctgcggcagt tcctgaagat gaactccacc ggcgacttcg acctgcacct gctgaaggtg      300

tccgagggca ccaccatcct gctgaactgc accggacagg tgaagggccg gaaacctgct      360

gctctgggag aggcccaacc caccaagagc ctggaggaga acaagtccct gaaggagcag      420

aagaagctga acgacctgtg cttcctgaag aggctgctgc aggagatcaa gacctgctgg      480

aacaagatcc tgatgggcac caaggagcat agcggcacaa ccaacacagt cgctgcctat      540

aacctcactt ggaagagcac caacttcaaa accatcctcg aatgggaacc caaacccgtt      600

aaccaagttt acaccgtgca gatcagcacc aagtccggcg actggaagtc caaatgtttc      660

tataccaccg acaccgagtg cgatctcacc gatgagatcg tgaaagatgt gaaacagacc      720

tacctcgccc gggtgtttag ctaccccgcc ggcaatgtgg agagcactgg ttccgctggc      780

gagcctttat acgagaacag ccccgaattt accccttacc tcgagaccaa tttaggacag      840

cccaccatcc aaagctttga gcaagttggc acaaaggtga atgtgacagt ggaggacgag      900

cggactttag tgcggcggaa caacaccttt ctcagcctcc gggatgtgtt cggcaaagat      960

ttaatctaca cactgtatta ctggaagtcc tcttcctccg gcaagaagac agctaaaacc     1020

aacacaaacg agtttttaat cgacgtggat aaaggcgaaa actactgttt cagcgtgcaa     1080

gctgtgatcc cctcccggac cgtgaatagg aaaagcaccg atagccccgt tgagtgcatg     1140

ggccaagaaa agggcgagtt ccgggagaac tgggtgaacg tcatcagcga tttaaagaag     1200

atcgaagatt taattcagtc catgcatatc gacgccactt tatacacaga atccgacgtg     1260

cacccctctt gtaaggtgac cgccatgaaa tgttttttac tggagctgca agttatctct     1320

ttagagagcg gagacgctag catccacgac accgtggaga atttaatcat tttagccaat     1380

aactctttat ccagcaacgg caacgtgaca gagtccggct gcaaggagtg cgaagagctg     1440

gaggagaaga acatcaagga gtttctgcaa tcctttgtgc acattgtcca gatgttcatc     1500

aatacctcc                                                             1509


<210> 177
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-TGFRs sequence"

<400> 177
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile 
        275                 280                 285             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    290                 295                 300                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
305                 310                 315                 320 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                325                 330                 335     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            340                 345                 350         


<210> 178
<211> 1056
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-TGFRs sequence"

<400> 178
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cattacatgc ccccctccca tgagcgtgga gcacgccgac      900

atctgggtga agagctatag cctctacagc cgggagaggt atatctgtaa cagcggcttc      960

aagaggaagg ccggcaccag cagcctcacc gagtgcgtgc tgaataaggc taccaacgtg     1020

gctcactgga caacaccctc tttaaagtgc atccgg                               1056


<210> 179
<211> 370
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-TGFRs sequence"

<400> 179
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg 
    370 


<210> 180
<211> 1110
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      7t15-TGFRs sequence"

<400> 180
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacattac atgcccccct cccatgagcg tggagcacgc cgacatctgg      960

gtgaagagct atagcctcta cagccgggag aggtatatct gtaacagcgg cttcaagagg     1020

aaggccggca ccagcagcct caccgagtgc gtgctgaata aggctaccaa cgtggctcac     1080

tggacaacac cctctttaaa gtgcatccgg                                      1110


<210> 181
<211> 620
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 181
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser 
        275                 280                 285             


Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr 
    290                 295                 300                 


Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val 
305                 310                 315                 320 


Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys 
                325                 330                 335     


Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
            340                 345                 350         


Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly 
        355                 360                 365             


Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser 
    370                 375                 380                 


Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile 
385                 390                 395                 400 


Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp 
                405                 410                 415     


Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp 
            420                 425                 430         


Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser 
        435                 440                 445             


Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile 
    450                 455                 460                 


Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile 
465                 470                 475                 480 


Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys 
                485                 490                 495     


Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile 
            500                 505                 510         


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        515                 520                 525             


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    530                 535                 540                 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
545                 550                 555                 560 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                565                 570                 575     


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            580                 585                 590         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        595                 600                 605             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620 


<210> 182
<211> 1860
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 182
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cagcggcaca accaacacag tcgctgccta taacctcact      900

tggaagagca ccaacttcaa aaccatcctc gaatgggaac ccaaacccgt taaccaagtt      960

tacaccgtgc agatcagcac caagtccggc gactggaagt ccaaatgttt ctataccacc     1020

gacaccgagt gcgatctcac cgatgagatc gtgaaagatg tgaaacagac ctacctcgcc     1080

cgggtgttta gctaccccgc cggcaatgtg gagagcactg gttccgctgg cgagccttta     1140

tacgagaaca gccccgaatt taccccttac ctcgagacca atttaggaca gcccaccatc     1200

caaagctttg agcaagttgg cacaaaggtg aatgtgacag tggaggacga gcggacttta     1260

gtgcggcgga acaacacctt tctcagcctc cgggatgtgt tcggcaaaga tttaatctac     1320

acactgtatt actggaagtc ctcttcctcc ggcaagaaga cagctaaaac caacacaaac     1380

gagtttttaa tcgacgtgga taaaggcgaa aactactgtt tcagcgtgca agctgtgatc     1440

ccctcccgga ccgtgaatag gaaaagcacc gatagccccg ttgagtgcat gggccaagaa     1500

aagggcgagt tccgggagaa ctgggtgaac gtcatcagcg atttaaagaa gatcgaagat     1560

ttaattcagt ccatgcatat cgacgccact ttatacacag aatccgacgt gcacccctct     1620

tgtaaggtga ccgccatgaa atgtttttta ctggagctgc aagttatctc tttagagagc     1680

ggagacgcta gcatccacga caccgtggag aatttaatca ttttagccaa taactcttta     1740

tccagcaacg gcaacgtgac agagtccggc tgcaaggagt gcgaagagct ggaggagaag     1800

aacatcaagg agtttctgca atcctttgtg cacattgtcc agatgttcat caatacctcc     1860


<210> 183
<211> 638
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 183
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys 
305                 310                 315                 320 


Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn 
                325                 330                 335     


Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser 
            340                 345                 350         


Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile 
        355                 360                 365             


Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro 
    370                 375                 380                 


Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu 
385                 390                 395                 400 


Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro 
                405                 410                 415     


Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val 
            420                 425                 430         


Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu 
        435                 440                 445             


Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys 
    450                 455                 460                 


Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe 
465                 470                 475                 480 


Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala 
                485                 490                 495     


Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val 
            500                 505                 510         


Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn 
        515                 520                 525             


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
    530                 535                 540                 


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
545                 550                 555                 560 


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
                565                 570                 575     


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
            580                 585                 590         


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
        595                 600                 605             


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
    610                 615                 620                 


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
625                 630                 635             


<210> 184
<211> 1914
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 184
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacagcgg cacaaccaac acagtcgctg cctataacct cacttggaag      960

agcaccaact tcaaaaccat cctcgaatgg gaacccaaac ccgttaacca agtttacacc     1020

gtgcagatca gcaccaagtc cggcgactgg aagtccaaat gtttctatac caccgacacc     1080

gagtgcgatc tcaccgatga gatcgtgaaa gatgtgaaac agacctacct cgcccgggtg     1140

tttagctacc ccgccggcaa tgtggagagc actggttccg ctggcgagcc tttatacgag     1200

aacagccccg aatttacccc ttacctcgag accaatttag gacagcccac catccaaagc     1260

tttgagcaag ttggcacaaa ggtgaatgtg acagtggagg acgagcggac tttagtgcgg     1320

cggaacaaca cctttctcag cctccgggat gtgttcggca aagatttaat ctacacactg     1380

tattactgga agtcctcttc ctccggcaag aagacagcta aaaccaacac aaacgagttt     1440

ttaatcgacg tggataaagg cgaaaactac tgtttcagcg tgcaagctgt gatcccctcc     1500

cggaccgtga ataggaaaag caccgatagc cccgttgagt gcatgggcca agaaaagggc     1560

gagttccggg agaactgggt gaacgtcatc agcgatttaa agaagatcga agatttaatt     1620

cagtccatgc atatcgacgc cactttatac acagaatccg acgtgcaccc ctcttgtaag     1680

gtgaccgcca tgaaatgttt tttactggag ctgcaagtta tctctttaga gagcggagac     1740

gctagcatcc acgacaccgt ggagaattta atcattttag ccaataactc tttatccagc     1800

aacggcaacg tgacagagtc cggctgcaag gagtgcgaag agctggagga gaagaacatc     1860

aaggagtttc tgcaatcctt tgtgcacatt gtccagatgt tcatcaatac ctcc           1914


<210> 185
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 185
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
    130                 135                 140                 


Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
145                 150                 155                 160 


Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
                165                 170                 175     


Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
            180                 185                 190         


Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
    210                 215                 220                 


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
225                 230                 235                 240 


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
                245                 250                 255     


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
            260                 265                 270         


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
        275                 280                 285             


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
    290                 295                 300                 


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
305                 310                 315                 320 


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
                325                 330                 335     


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
            340                 345                 350         


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
        355                 360                 365             


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
    370                 375                 380                 


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
385                 390                 395         


<210> 186
<211> 1191
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 186
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcca ttacatgccc ccctcccatg      420

agcgtggagc acgccgacat ctgggtgaag agctatagcc tctacagccg ggagaggtat      480

atctgtaaca gcggcttcaa gaggaaggcc ggcaccagca gcctcaccga gtgcgtgctg      540

aataaggcta ccaacgtggc tcactggaca acaccctctt taaagtgcat ccggggcggt      600

ggaggatccg gaggaggtgg ctccggcggc ggaggatctc gcgagggtcc cgagctttcg      660

cccgacgatc ccgccggcct cttggacctg cggcagggca tgtttgcgca gctggtggcc      720

caaaatgttc tgctgatcga tgggcccctg agctggtaca gtgacccagg cctggcaggc      780

gtgtccctga cggggggcct gagctacaaa gaggacacga aggagctggt ggtggccaag      840

gctggagtct actatgtctt ctttcaacta gagctgcggc gcgtggtggc cggcgagggc      900

tcaggctccg tttcacttgc gctgcacctg cagccactgc gctctgctgc tggggccgcc      960

gccctggctt tgaccgtgga cctgccaccc gcctcctccg aggctcggaa ctcggccttc     1020

ggtttccagg gccgcttgct gcacctgagt gccggccagc gcctgggcgt ccatcttcac     1080

actgaggcca gggcacgcca tgcctggcag cttacccagg gcgccacagt cttgggactc     1140

ttccgggtga cccccgaaat cccagccgga ctcccttcac cgaggtcgga a              1191


<210> 187
<211> 415
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 187
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp 
225                 230                 235                 240 


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                245                 250                 255     


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            260                 265                 270         


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        275                 280                 285             


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    290                 295                 300                 


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
305                 310                 315                 320 


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                325                 330                 335     


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            340                 345                 350         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        355                 360                 365             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    370                 375                 380                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
385                 390                 395                 400 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                405                 410                 415 


<210> 188
<211> 1245
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 188
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tccattacat gcccccctcc catgagcgtg      480

gagcacgccg acatctgggt gaagagctat agcctctaca gccgggagag gtatatctgt      540

aacagcggct tcaagaggaa ggccggcacc agcagcctca ccgagtgcgt gctgaataag      600

gctaccaacg tggctcactg gacaacaccc tctttaaagt gcatccgggg cggtggagga      660

tccggaggag gtggctccgg cggcggagga tctcgcgagg gtcccgagct ttcgcccgac      720

gatcccgccg gcctcttgga cctgcggcag ggcatgtttg cgcagctggt ggcccaaaat      780

gttctgctga tcgatgggcc cctgagctgg tacagtgacc caggcctggc aggcgtgtcc      840

ctgacggggg gcctgagcta caaagaggac acgaaggagc tggtggtggc caaggctgga      900

gtctactatg tcttctttca actagagctg cggcgcgtgg tggccggcga gggctcaggc      960

tccgtttcac ttgcgctgca cctgcagcca ctgcgctctg ctgctggggc cgccgccctg     1020

gctttgaccg tggacctgcc acccgcctcc tccgaggctc ggaactcggc cttcggtttc     1080

cagggccgct tgctgcacct gagtgccggc cagcgcctgg gcgtccatct tcacactgag     1140

gccagggcac gccatgcctg gcagcttacc cagggcgcca cagtcttggg actcttccgg     1200

gtgacccccg aaatcccagc cggactccct tcaccgaggt cggaa                     1245


<210> 189
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 189
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             


Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His 
    130                 135                 140                 


Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr 
145                 150                 155                 160 


Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr 
                165                 170                 175     


Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro 
            180                 185                 190         


Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
    210                 215                 220                 


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
225                 230                 235                 240 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
                245                 250                 255     


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
            260                 265                 270         


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
        275                 280                 285             


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
    290                 295                 300                 


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
305                 310                 315                 320 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
                325                 330                 335     


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
            340                 345                 350         


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
        355                 360                 365             


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
    370                 375             


<210> 190
<211> 1134
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 190
cagggccagg acaggcacat gatccggatg aggcagctca tcgacatcgt cgaccagctg       60

aagaactacg tgaacgacct ggtgcccgag tttctgcctg cccccgagga cgtggagacc      120

aactgcgagt ggtccgcctt ctcctgcttt cagaaggccc agctgaagtc cgccaacacc      180

ggcaacaacg agcggatcat caacgtgagc atcaagaagc tgaagcggaa gcctccctcc      240

acaaacgccg gcaggaggca gaagcacagg ctgacctgcc ccagctgtga ctcctacgag      300

aagaagcccc ccaaggagtt cctggagagg ttcaagtccc tgctgcagaa gatgatccat      360

cagcacctgt cctccaggac ccacggctcc gaggactcca ttacatgccc ccctcccatg      420

agcgtggagc acgccgacat ctgggtgaag agctatagcc tctacagccg ggagaggtat      480

atctgtaaca gcggcttcaa gaggaaggcc ggcaccagca gcctcaccga gtgcgtgctg      540

aataaggcta ccaacgtggc tcactggaca acaccctctt taaagtgcat ccggggcggt      600

ggaggatccg gaggaggtgg ctccggcggc ggaggatctg atcccgccgg cctcttggac      660

ctgcggcagg gcatgtttgc gcagctggtg gcccaaaatg ttctgctgat cgatgggccc      720

ctgagctggt acagtgaccc aggcctggca ggcgtgtccc tgacgggggg cctgagctac      780

aaagaggaca cgaaggagct ggtggtggcc aaggctggag tctactatgt cttctttcaa      840

ctagagctgc ggcgcgtggt ggccggcgag ggctcaggct ccgtttcact tgcgctgcac      900

ctgcagccac tgcgctctgc tgctggggcc gccgccctgg ctttgaccgt ggacctgcca      960

cccgcctcct ccgaggctcg gaactcggcc ttcggtttcc agggccgctt gctgcacctg     1020

agtgccggcc agcgcctggg cgtccatctt cacactgagg ccagggcacg ccatgcctgg     1080

cagcttaccc agggcgccac agtcttggga ctcttccggg tgacccccga aatc           1134


<210> 191
<211> 396
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 191
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg 
225                 230                 235                 240 


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                245                 250                 255     


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            260                 265                 270         


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        275                 280                 285             


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    290                 295                 300                 


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
305                 310                 315                 320 


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                325                 330                 335     


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            340                 345                 350         


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        355                 360                 365             


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    370                 375                 380                 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
385                 390                 395     


<210> 192
<211> 1188
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-21s137L sequence"

<400> 192
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tccattacat gcccccctcc catgagcgtg      480

gagcacgccg acatctgggt gaagagctat agcctctaca gccgggagag gtatatctgt      540

aacagcggct tcaagaggaa ggccggcacc agcagcctca ccgagtgcgt gctgaataag      600

gctaccaacg tggctcactg gacaacaccc tctttaaagt gcatccgggg cggtggagga      660

tccggaggag gtggctccgg cggcggagga tctgatcccg ccggcctctt ggacctgcgg      720

cagggcatgt ttgcgcagct ggtggcccaa aatgttctgc tgatcgatgg gcccctgagc      780

tggtacagtg acccaggcct ggcaggcgtg tccctgacgg ggggcctgag ctacaaagag      840

gacacgaagg agctggtggt ggccaaggct ggagtctact atgtcttctt tcaactagag      900

ctgcggcgcg tggtggccgg cgagggctca ggctccgttt cacttgcgct gcacctgcag      960

ccactgcgct ctgctgctgg ggccgccgcc ctggctttga ccgtggacct gccacccgcc     1020

tcctccgagg ctcggaactc ggccttcggt ttccagggcc gcttgctgca cctgagtgcc     1080

ggccagcgcc tgggcgtcca tcttcacact gaggccaggg cacgccatgc ctggcagctt     1140

acccagggcg ccacagtctt gggactcttc cgggtgaccc ccgaaatc                  1188


<210> 193
<211> 620
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 193
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser 
        275                 280                 285             


Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr 
    290                 295                 300                 


Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val 
305                 310                 315                 320 


Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys 
                325                 330                 335     


Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
            340                 345                 350         


Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly 
        355                 360                 365             


Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser 
    370                 375                 380                 


Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile 
385                 390                 395                 400 


Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp 
                405                 410                 415     


Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp 
            420                 425                 430         


Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser 
        435                 440                 445             


Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile 
    450                 455                 460                 


Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile 
465                 470                 475                 480 


Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys 
                485                 490                 495     


Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile 
            500                 505                 510         


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        515                 520                 525             


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    530                 535                 540                 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
545                 550                 555                 560 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                565                 570                 575     


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            580                 585                 590         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        595                 600                 605             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620 


<210> 194
<211> 1860
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 194
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cagcggcaca accaacacag tcgctgccta taacctcact      900

tggaagagca ccaacttcaa aaccatcctc gaatgggaac ccaaacccgt taaccaagtt      960

tacaccgtgc agatcagcac caagtccggc gactggaagt ccaaatgttt ctataccacc     1020

gacaccgagt gcgatctcac cgatgagatc gtgaaagatg tgaaacagac ctacctcgcc     1080

cgggtgttta gctaccccgc cggcaatgtg gagagcactg gttccgctgg cgagccttta     1140

tacgagaaca gccccgaatt taccccttac ctcgagacca atttaggaca gcccaccatc     1200

caaagctttg agcaagttgg cacaaaggtg aatgtgacag tggaggacga gcggacttta     1260

gtgcggcgga acaacacctt tctcagcctc cgggatgtgt tcggcaaaga tttaatctac     1320

acactgtatt actggaagtc ctcttcctcc ggcaagaaga cagctaaaac caacacaaac     1380

gagtttttaa tcgacgtgga taaaggcgaa aactactgtt tcagcgtgca agctgtgatc     1440

ccctcccgga ccgtgaatag gaaaagcacc gatagccccg ttgagtgcat gggccaagaa     1500

aagggcgagt tccgggagaa ctgggtgaac gtcatcagcg atttaaagaa gatcgaagat     1560

ttaattcagt ccatgcatat cgacgccact ttatacacag aatccgacgt gcacccctct     1620

tgtaaggtga ccgccatgaa atgtttttta ctggagctgc aagttatctc tttagagagc     1680

ggagacgcta gcatccacga caccgtggag aatttaatca ttttagccaa taactcttta     1740

tccagcaacg gcaacgtgac agagtccggc tgcaaggagt gcgaagagct ggaggagaag     1800

aacatcaagg agtttctgca atcctttgtg cacattgtcc agatgttcat caatacctcc     1860


<210> 195
<211> 638
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 195
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys 
305                 310                 315                 320 


Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn 
                325                 330                 335     


Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser 
            340                 345                 350         


Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile 
        355                 360                 365             


Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro 
    370                 375                 380                 


Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu 
385                 390                 395                 400 


Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro 
                405                 410                 415     


Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val 
            420                 425                 430         


Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu 
        435                 440                 445             


Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys 
    450                 455                 460                 


Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe 
465                 470                 475                 480 


Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala 
                485                 490                 495     


Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val 
            500                 505                 510         


Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn 
        515                 520                 525             


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
    530                 535                 540                 


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
545                 550                 555                 560 


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
                565                 570                 575     


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
            580                 585                 590         


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
        595                 600                 605             


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
    610                 615                 620                 


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
625                 630                 635             


<210> 196
<211> 1914
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 196
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacagcgg cacaaccaac acagtcgctg cctataacct cacttggaag      960

agcaccaact tcaaaaccat cctcgaatgg gaacccaaac ccgttaacca agtttacacc     1020

gtgcagatca gcaccaagtc cggcgactgg aagtccaaat gtttctatac caccgacacc     1080

gagtgcgatc tcaccgatga gatcgtgaaa gatgtgaaac agacctacct cgcccgggtg     1140

tttagctacc ccgccggcaa tgtggagagc actggttccg ctggcgagcc tttatacgag     1200

aacagccccg aatttacccc ttacctcgag accaatttag gacagcccac catccaaagc     1260

tttgagcaag ttggcacaaa ggtgaatgtg acagtggagg acgagcggac tttagtgcgg     1320

cggaacaaca cctttctcag cctccgggat gtgttcggca aagatttaat ctacacactg     1380

tattactgga agtcctcttc ctccggcaag aagacagcta aaaccaacac aaacgagttt     1440

ttaatcgacg tggataaagg cgaaaactac tgtttcagcg tgcaagctgt gatcccctcc     1500

cggaccgtga ataggaaaag caccgatagc cccgttgagt gcatgggcca agaaaagggc     1560

gagttccggg agaactgggt gaacgtcatc agcgatttaa agaagatcga agatttaatt     1620

cagtccatgc atatcgacgc cactttatac acagaatccg acgtgcaccc ctcttgtaag     1680

gtgaccgcca tgaaatgttt tttactggag ctgcaagtta tctctttaga gagcggagac     1740

gctagcatcc acgacaccgt ggagaattta atcattttag ccaataactc tttatccagc     1800

aacggcaacg tgacagagtc cggctgcaag gagtgcgaag agctggagga gaagaacatc     1860

aaggagtttc tgcaatcctt tgtgcacatt gtccagatgt tcatcaatac ctcc           1914


<210> 197
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 197
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile 
        275                 280                 285             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    290                 295                 300                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
305                 310                 315                 320 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                325                 330                 335     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            340                 345                 350         


Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
        355                 360                 365             


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
    370                 375                 380                 


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
385                 390                 395                 400 


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
                405                 410                 415     


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
            420                 425                 430         


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
        435                 440                 445             


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
    450                 455                 460                 


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
465                 470                 475                 480 


Gly Ser Glu Asp Ser 
                485 


<210> 198
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 198
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cattacatgc ccccctccca tgagcgtgga gcacgccgac      900

atctgggtga agagctatag cctctacagc cgggagaggt atatctgtaa cagcggcttc      960

aagaggaagg ccggcaccag cagcctcacc gagtgcgtgc tgaataaggc taccaacgtg     1020

gctcactgga caacaccctc tttaaagtgc atccggcagg gccaggacag gcacatgatc     1080

cggatgaggc agctcatcga catcgtcgac cagctgaaga actacgtgaa cgacctggtg     1140

cccgagtttc tgcctgcccc cgaggacgtg gagaccaact gcgagtggtc cgccttctcc     1200

tgctttcaga aggcccagct gaagtccgcc aacaccggca acaacgagcg gatcatcaac     1260

gtgagcatca agaagctgaa gcggaagcct ccctccacaa acgccggcag gaggcagaag     1320

cacaggctga cctgccccag ctgtgactcc tacgagaaga agccccccaa ggagttcctg     1380

gagaggttca agtccctgct gcagaagatg atccatcagc acctgtcctc caggacccac     1440

ggctccgagg actcc                                                      1455


<210> 199
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 199
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
    370                 375                 380                 


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
385                 390                 395                 400 


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
                405                 410                 415     


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
            420                 425                 430         


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
        435                 440                 445             


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
    450                 455                 460                 


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
465                 470                 475                 480 


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
                485                 490                 495     


Thr His Gly Ser Glu Asp Ser 
            500             


<210> 200
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs21 sequence"

<400> 200
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacattac atgcccccct cccatgagcg tggagcacgc cgacatctgg      960

gtgaagagct atagcctcta cagccgggag aggtatatct gtaacagcgg cttcaagagg     1020

aaggccggca ccagcagcct caccgagtgc gtgctgaata aggctaccaa cgtggctcac     1080

tggacaacac cctctttaaa gtgcatccgg cagggccagg acaggcacat gatccggatg     1140

aggcagctca tcgacatcgt cgaccagctg aagaactacg tgaacgacct ggtgcccgag     1200

tttctgcctg cccccgagga cgtggagacc aactgcgagt ggtccgcctt ctcctgcttt     1260

cagaaggccc agctgaagtc cgccaacacc ggcaacaacg agcggatcat caacgtgagc     1320

atcaagaagc tgaagcggaa gcctccctcc acaaacgccg gcaggaggca gaagcacagg     1380

ctgacctgcc ccagctgtga ctcctacgag aagaagcccc ccaaggagtt cctggagagg     1440

ttcaagtccc tgctgcagaa gatgatccat cagcacctgt cctccaggac ccacggctcc     1500

gaggactcc                                                             1509


<210> 201
<211> 620
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 201
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser 
        275                 280                 285             


Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr 
    290                 295                 300                 


Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val 
305                 310                 315                 320 


Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys 
                325                 330                 335     


Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
            340                 345                 350         


Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly 
        355                 360                 365             


Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser 
    370                 375                 380                 


Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile 
385                 390                 395                 400 


Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp 
                405                 410                 415     


Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp 
            420                 425                 430         


Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser 
        435                 440                 445             


Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile 
    450                 455                 460                 


Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile 
465                 470                 475                 480 


Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys 
                485                 490                 495     


Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile 
            500                 505                 510         


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        515                 520                 525             


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    530                 535                 540                 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
545                 550                 555                 560 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                565                 570                 575     


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            580                 585                 590         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        595                 600                 605             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620 


<210> 202
<211> 1860
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 202
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cagcggcaca accaacacag tcgctgccta taacctcact      900

tggaagagca ccaacttcaa aaccatcctc gaatgggaac ccaaacccgt taaccaagtt      960

tacaccgtgc agatcagcac caagtccggc gactggaagt ccaaatgttt ctataccacc     1020

gacaccgagt gcgatctcac cgatgagatc gtgaaagatg tgaaacagac ctacctcgcc     1080

cgggtgttta gctaccccgc cggcaatgtg gagagcactg gttccgctgg cgagccttta     1140

tacgagaaca gccccgaatt taccccttac ctcgagacca atttaggaca gcccaccatc     1200

caaagctttg agcaagttgg cacaaaggtg aatgtgacag tggaggacga gcggacttta     1260

gtgcggcgga acaacacctt tctcagcctc cgggatgtgt tcggcaaaga tttaatctac     1320

acactgtatt actggaagtc ctcttcctcc ggcaagaaga cagctaaaac caacacaaac     1380

gagtttttaa tcgacgtgga taaaggcgaa aactactgtt tcagcgtgca agctgtgatc     1440

ccctcccgga ccgtgaatag gaaaagcacc gatagccccg ttgagtgcat gggccaagaa     1500

aagggcgagt tccgggagaa ctgggtgaac gtcatcagcg atttaaagaa gatcgaagat     1560

ttaattcagt ccatgcatat cgacgccact ttatacacag aatccgacgt gcacccctct     1620

tgtaaggtga ccgccatgaa atgtttttta ctggagctgc aagttatctc tttagagagc     1680

ggagacgcta gcatccacga caccgtggag aatttaatca ttttagccaa taactcttta     1740

tccagcaacg gcaacgtgac agagtccggc tgcaaggagt gcgaagagct ggaggagaag     1800

aacatcaagg agtttctgca atcctttgtg cacattgtcc agatgttcat caatacctcc     1860


<210> 203
<211> 638
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 203
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys 
305                 310                 315                 320 


Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn 
                325                 330                 335     


Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser 
            340                 345                 350         


Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile 
        355                 360                 365             


Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro 
    370                 375                 380                 


Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu 
385                 390                 395                 400 


Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro 
                405                 410                 415     


Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val 
            420                 425                 430         


Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu 
        435                 440                 445             


Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys 
    450                 455                 460                 


Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe 
465                 470                 475                 480 


Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala 
                485                 490                 495     


Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val 
            500                 505                 510         


Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn 
        515                 520                 525             


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
    530                 535                 540                 


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
545                 550                 555                 560 


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
                565                 570                 575     


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
            580                 585                 590         


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
        595                 600                 605             


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
    610                 615                 620                 


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
625                 630                 635             


<210> 204
<211> 1914
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 204
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacagcgg cacaaccaac acagtcgctg cctataacct cacttggaag      960

agcaccaact tcaaaaccat cctcgaatgg gaacccaaac ccgttaacca agtttacacc     1020

gtgcagatca gcaccaagtc cggcgactgg aagtccaaat gtttctatac caccgacacc     1080

gagtgcgatc tcaccgatga gatcgtgaaa gatgtgaaac agacctacct cgcccgggtg     1140

tttagctacc ccgccggcaa tgtggagagc actggttccg ctggcgagcc tttatacgag     1200

aacagccccg aatttacccc ttacctcgag accaatttag gacagcccac catccaaagc     1260

tttgagcaag ttggcacaaa ggtgaatgtg acagtggagg acgagcggac tttagtgcgg     1320

cggaacaaca cctttctcag cctccgggat gtgttcggca aagatttaat ctacacactg     1380

tattactgga agtcctcttc ctccggcaag aagacagcta aaaccaacac aaacgagttt     1440

ttaatcgacg tggataaagg cgaaaactac tgtttcagcg tgcaagctgt gatcccctcc     1500

cggaccgtga ataggaaaag caccgatagc cccgttgagt gcatgggcca agaaaagggc     1560

gagttccggg agaactgggt gaacgtcatc agcgatttaa agaagatcga agatttaatt     1620

cagtccatgc atatcgacgc cactttatac acagaatccg acgtgcaccc ctcttgtaag     1680

gtgaccgcca tgaaatgttt tttactggag ctgcaagtta tctctttaga gagcggagac     1740

gctagcatcc acgacaccgt ggagaattta atcattttag ccaataactc tttatccagc     1800

aacggcaacg tgacagagtc cggctgcaag gagtgcgaag agctggagga gaagaacatc     1860

aaggagtttc tgcaatcctt tgtgcacatt gtccagatgt tcatcaatac ctcc           1914


<210> 205
<211> 592
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 205
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile 
        275                 280                 285             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    290                 295                 300                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
305                 310                 315                 320 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                325                 330                 335     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            340                 345                 350         


Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
        355                 360                 365             


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
    370                 375                 380                 


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
385                 390                 395                 400 


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
                405                 410                 415     


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
            420                 425                 430         


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val 
        435                 440                 445             


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
465                 470                 475                 480 


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
                485                 490                 495     


Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser Trp Val 
            500                 505                 510         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp 
        515                 520                 525             


Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    530                 535                 540                 


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
545                 550                 555                 560 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Ser 
                565                 570                 575     


Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg 
            580                 585                 590         


<210> 206
<211> 1776
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 206
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cattacatgc ccccctccca tgagcgtgga gcacgccgac      900

atctgggtga agagctatag cctctacagc cgggagaggt atatctgtaa cagcggcttc      960

aagaggaagg ccggcaccag cagcctcacc gagtgcgtgc tgaataaggc taccaacgtg     1020

gctcactgga caacaccctc tttaaagtgc atccggtccg agctgaccca ggaccctgct     1080

gtgtccgtgg ctctgggcca gaccgtgagg atcacctgcc agggcgactc cctgaggtcc     1140

tactacgcct cctggtacca gcagaagccc ggccaggctc ctgtgctggt gatctacggc     1200

aagaacaaca ggccctccgg catccctgac aggttctccg gatcctcctc cggcaacacc     1260

gcctccctga ccatcacagg cgctcaggcc gaggacgagg ctgactacta ctgcaactcc     1320

agggactcct ccggcaacca tgtggtgttc ggcggcggca ccaagctgac cgtgggccat     1380

ggcggcggcg gctccggagg cggcggcagc ggcggaggag gatccgaggt gcagctggtg     1440

gagtccggag gaggagtggt gaggcctgga ggctccctga ggctgagctg tgctgcctcc     1500

ggcttcacct tcgacgacta cggcatgtcc tgggtgaggc aggctcctgg aaagggcctg     1560

gagtgggtgt ccggcatcaa ctggaacggc ggatccaccg gctacgccga ttccgtgaag     1620

ggcaggttca ccatcagcag ggacaacgcc aagaactccc tgtacctgca gatgaactcc     1680

ctgagggccg aggacaccgc cgtgtactac tgcgccaggg gcaggtccct gctgttcgac     1740

tactggggac agggcaccct ggtgaccgtg tccagg                               1776


<210> 207
<211> 610
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 207
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
    370                 375                 380                 


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 
385                 390                 395                 400 


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
                405                 410                 415     


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
            420                 425                 430         


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
        435                 440                 445             


Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn 
    450                 455                 460                 


His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly His Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                485                 490                 495     


Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg 
            500                 505                 510         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Ser 
        515                 520                 525             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile 
    530                 535                 540                 


Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg 
545                 550                 555                 560 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
                565                 570                 575     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
            580                 585                 590         


Arg Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        595                 600                 605             


Ser Arg 
    610 


<210> 208
<211> 1830
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs16 sequence"

<400> 208
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacattac atgcccccct cccatgagcg tggagcacgc cgacatctgg      960

gtgaagagct atagcctcta cagccgggag aggtatatct gtaacagcgg cttcaagagg     1020

aaggccggca ccagcagcct caccgagtgc gtgctgaata aggctaccaa cgtggctcac     1080

tggacaacac cctctttaaa gtgcatccgg tccgagctga cccaggaccc tgctgtgtcc     1140

gtggctctgg gccagaccgt gaggatcacc tgccagggcg actccctgag gtcctactac     1200

gcctcctggt accagcagaa gcccggccag gctcctgtgc tggtgatcta cggcaagaac     1260

aacaggccct ccggcatccc tgacaggttc tccggatcct cctccggcaa caccgcctcc     1320

ctgaccatca caggcgctca ggccgaggac gaggctgact actactgcaa ctccagggac     1380

tcctccggca accatgtggt gttcggcggc ggcaccaagc tgaccgtggg ccatggcggc     1440

ggcggctccg gaggcggcgg cagcggcgga ggaggatccg aggtgcagct ggtggagtcc     1500

ggaggaggag tggtgaggcc tggaggctcc ctgaggctga gctgtgctgc ctccggcttc     1560

accttcgacg actacggcat gtcctgggtg aggcaggctc ctggaaaggg cctggagtgg     1620

gtgtccggca tcaactggaa cggcggatcc accggctacg ccgattccgt gaagggcagg     1680

ttcaccatca gcagggacaa cgccaagaac tccctgtacc tgcagatgaa ctccctgagg     1740

gccgaggaca ccgccgtgta ctactgcgcc aggggcaggt ccctgctgtt cgactactgg     1800

ggacagggca ccctggtgac cgtgtccagg                                      1830


<210> 209
<211> 620
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 209
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ser 
        275                 280                 285             


Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser Thr 
    290                 295                 300                 


Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln Val 
305                 310                 315                 320 


Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys Cys 
                325                 330                 335     


Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val Lys 
            340                 345                 350         


Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala Gly 
        355                 360                 365             


Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn Ser 
    370                 375                 380                 


Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr Ile 
385                 390                 395                 400 


Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu Asp 
                405                 410                 415     


Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg Asp 
            420                 425                 430         


Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser 
        435                 440                 445             


Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu Ile 
    450                 455                 460                 


Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val Ile 
465                 470                 475                 480 


Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu Cys 
                485                 490                 495     


Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn Val Ile 
            500                 505                 510         


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        515                 520                 525             


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    530                 535                 540                 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
545                 550                 555                 560 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                565                 570                 575     


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            580                 585                 590         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        595                 600                 605             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620 


<210> 210
<211> 1860
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 210
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cagcggcaca accaacacag tcgctgccta taacctcact      900

tggaagagca ccaacttcaa aaccatcctc gaatgggaac ccaaacccgt taaccaagtt      960

tacaccgtgc agatcagcac caagtccggc gactggaagt ccaaatgttt ctataccacc     1020

gacaccgagt gcgatctcac cgatgagatc gtgaaagatg tgaaacagac ctacctcgcc     1080

cgggtgttta gctaccccgc cggcaatgtg gagagcactg gttccgctgg cgagccttta     1140

tacgagaaca gccccgaatt taccccttac ctcgagacca atttaggaca gcccaccatc     1200

caaagctttg agcaagttgg cacaaaggtg aatgtgacag tggaggacga gcggacttta     1260

gtgcggcgga acaacacctt tctcagcctc cgggatgtgt tcggcaaaga tttaatctac     1320

acactgtatt actggaagtc ctcttcctcc ggcaagaaga cagctaaaac caacacaaac     1380

gagtttttaa tcgacgtgga taaaggcgaa aactactgtt tcagcgtgca agctgtgatc     1440

ccctcccgga ccgtgaatag gaaaagcacc gatagccccg ttgagtgcat gggccaagaa     1500

aagggcgagt tccgggagaa ctgggtgaac gtcatcagcg atttaaagaa gatcgaagat     1560

ttaattcagt ccatgcatat cgacgccact ttatacacag aatccgacgt gcacccctct     1620

tgtaaggtga ccgccatgaa atgtttttta ctggagctgc aagttatctc tttagagagc     1680

ggagacgcta gcatccacga caccgtggag aatttaatca ttttagccaa taactcttta     1740

tccagcaacg gcaacgtgac agagtccggc tgcaaggagt gcgaagagct ggaggagaag     1800

aacatcaagg agtttctgca atcctttgtg cacattgtcc agatgttcat caatacctcc     1860


<210> 211
<211> 638
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 211
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys 
305                 310                 315                 320 


Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn 
                325                 330                 335     


Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser 
            340                 345                 350         


Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile 
        355                 360                 365             


Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro 
    370                 375                 380                 


Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu 
385                 390                 395                 400 


Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro 
                405                 410                 415     


Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val 
            420                 425                 430         


Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu 
        435                 440                 445             


Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys 
    450                 455                 460                 


Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe 
465                 470                 475                 480 


Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala 
                485                 490                 495     


Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val 
            500                 505                 510         


Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Asn Trp Val Asn 
        515                 520                 525             


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
    530                 535                 540                 


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
545                 550                 555                 560 


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
                565                 570                 575     


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
            580                 585                 590         


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
        595                 600                 605             


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
    610                 615                 620                 


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
625                 630                 635             


<210> 212
<211> 1914
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 212
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacagcgg cacaaccaac acagtcgctg cctataacct cacttggaag      960

agcaccaact tcaaaaccat cctcgaatgg gaacccaaac ccgttaacca agtttacacc     1020

gtgcagatca gcaccaagtc cggcgactgg aagtccaaat gtttctatac caccgacacc     1080

gagtgcgatc tcaccgatga gatcgtgaaa gatgtgaaac agacctacct cgcccgggtg     1140

tttagctacc ccgccggcaa tgtggagagc actggttccg ctggcgagcc tttatacgag     1200

aacagccccg aatttacccc ttacctcgag accaatttag gacagcccac catccaaagc     1260

tttgagcaag ttggcacaaa ggtgaatgtg acagtggagg acgagcggac tttagtgcgg     1320

cggaacaaca cctttctcag cctccgggat gtgttcggca aagatttaat ctacacactg     1380

tattactgga agtcctcttc ctccggcaag aagacagcta aaaccaacac aaacgagttt     1440

ttaatcgacg tggataaagg cgaaaactac tgtttcagcg tgcaagctgt gatcccctcc     1500

cggaccgtga ataggaaaag caccgatagc cccgttgagt gcatgggcca agaaaagggc     1560

gagttccggg agaactgggt gaacgtcatc agcgatttaa agaagatcga agatttaatt     1620

cagtccatgc atatcgacgc cactttatac acagaatccg acgtgcaccc ctcttgtaag     1680

gtgaccgcca tgaaatgttt tttactggag ctgcaagtta tctctttaga gagcggagac     1740

gctagcatcc acgacaccgt ggagaattta atcattttag ccaataactc tttatccagc     1800

aacggcaacg tgacagagtc cggctgcaag gagtgcgaag agctggagga gaagaacatc     1860

aaggagtttc tgcaatcctt tgtgcacatt gtccagatgt tcatcaatac ctcc           1914


<210> 213
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 213
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val 
145                 150                 155                 160 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
                165                 170                 175     


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
            180                 185                 190         


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
        195                 200                 205             


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
    210                 215                 220                 


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
225                 230                 235                 240 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
                245                 250                 255     


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
            260                 265                 270         


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile 
        275                 280                 285             


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
    290                 295                 300                 


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
305                 310                 315                 320 


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
                325                 330                 335     


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
        355                 360                 365             


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
    370                 375                 380                 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
385                 390                 395                 400 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
                405                 410                 415     


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
            420                 425                 430         


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
        435                 440                 445             


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
    450                 455                 460                 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
465                 470                 475                 480 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                485                 490                 495     


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
            500                 505                 510         


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
        515                 520                 525             


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
    530                 535                 540                 


Leu Pro Ser Pro Arg Ser Glu 
545                 550     


<210> 214
<211> 1653
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 214
atcccccccc atgtgcaaaa gagcgtgaac aacgatatga tcgtgaccga caacaacggc       60

gccgtgaagt ttccccagct ctgcaagttc tgcgatgtca ggttcagcac ctgcgataat      120

cagaagtcct gcatgtccaa ctgcagcatc acctccatct gcgagaagcc ccaagaagtg      180

tgcgtggccg tgtggcggaa aaatgacgag aacatcaccc tggagaccgt gtgtcacgac      240

cccaagctcc cttatcacga cttcattctg gaggacgctg cctcccccaa atgcatcatg      300

aaggagaaga agaagcccgg agagaccttc tttatgtgtt cctgtagcag cgacgagtgt      360

aacgacaaca tcatcttcag cgaagagtac aacaccagca accctgatgg aggtggcgga      420

tccggaggtg gaggttctgg tggaggtggg agtattcctc cccacgtgca gaagagcgtg      480

aataatgaca tgatcgtgac cgataacaat ggcgccgtga aatttcccca gctgtgcaaa      540

ttctgcgatg tgaggttttc cacctgcgac aaccagaagt cctgtatgag caactgctcc      600

atcacctcca tctgtgagaa gcctcaggag gtgtgcgtgg ctgtctggcg gaagaatgac      660

gagaatatca ccctggaaac cgtctgccac gatcccaagc tgccctacca cgatttcatc      720

ctggaagacg ccgccagccc taagtgcatc atgaaagaga aaaagaagcc tggcgagacc      780

tttttcatgt gctcctgcag cagcgacgaa tgcaacgaca atatcatctt tagcgaggaa      840

tacaatacca gcaaccccga cattacatgc ccccctccca tgagcgtgga gcacgccgac      900

atctgggtga agagctatag cctctacagc cgggagaggt atatctgtaa cagcggcttc      960

aagaggaagg ccggcaccag cagcctcacc gagtgcgtgc tgaataaggc taccaacgtg     1020

gctcactgga caacaccctc tttaaagtgc atccggggcg gtggaggatc cggaggaggt     1080

ggctccggcg gcggaggatc tcgcgagggt cccgagcttt cgcccgacga tcccgccggc     1140

ctcttggacc tgcggcaggg catgtttgcg cagctggtgg cccaaaatgt tctgctgatc     1200

gatgggcccc tgagctggta cagtgaccca ggcctggcag gcgtgtccct gacggggggc     1260

ctgagctaca aagaggacac gaaggagctg gtggtggcca aggctggagt ctactatgtc     1320

ttctttcaac tagagctgcg gcgcgtggtg gccggcgagg gctcaggctc cgtttcactt     1380

gcgctgcacc tgcagccact gcgctctgct gctggggccg ccgccctggc tttgaccgtg     1440

gacctgccac ccgcctcctc cgaggctcgg aactcggcct tcggtttcca gggccgcttg     1500

ctgcacctga gtgccggcca gcgcctgggc gtccatcttc acactgaggc cagggcacgc     1560

catgcctggc agcttaccca gggcgccaca gtcttgggac tcttccgggt gacccccgaa     1620

atcccagccg gactcccttc accgaggtcg gaa                                  1653


<210> 215
<211> 569
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 215
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
        35                  40                  45              


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
    50                  55                  60                  


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
65                  70                  75                  80  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
                85                  90                  95      


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
            100                 105                 110         


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
        115                 120                 125             


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
    130                 135                 140                 


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys 
                165                 170                 175     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            180                 185                 190         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        195                 200                 205             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    210                 215                 220                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
225                 230                 235                 240 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                245                 250                 255     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            260                 265                 270         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        275                 280                 285             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    290                 295                 300                 


Asp Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
305                 310                 315                 320 


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
                325                 330                 335     


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
            340                 345                 350         


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
        355                 360                 365             


Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
385                 390                 395                 400 


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                405                 410                 415     


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
            420                 425                 430         


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
        435                 440                 445             


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
    450                 455                 460                 


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
465                 470                 475                 480 


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                485                 490                 495     


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
            500                 505                 510         


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
        515                 520                 525             


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
    530                 535                 540                 


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
545                 550                 555                 560 


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                565                 


<210> 216
<211> 1707
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      TGFRt15-TGFRs137 sequence"

<400> 216
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctccatcccc       60

ccccatgtgc aaaagagcgt gaacaacgat atgatcgtga ccgacaacaa cggcgccgtg      120

aagtttcccc agctctgcaa gttctgcgat gtcaggttca gcacctgcga taatcagaag      180

tcctgcatgt ccaactgcag catcacctcc atctgcgaga agccccaaga agtgtgcgtg      240

gccgtgtggc ggaaaaatga cgagaacatc accctggaga ccgtgtgtca cgaccccaag      300

ctcccttatc acgacttcat tctggaggac gctgcctccc ccaaatgcat catgaaggag      360

aagaagaagc ccggagagac cttctttatg tgttcctgta gcagcgacga gtgtaacgac      420

aacatcatct tcagcgaaga gtacaacacc agcaaccctg atggaggtgg cggatccgga      480

ggtggaggtt ctggtggagg tgggagtatt cctccccacg tgcagaagag cgtgaataat      540

gacatgatcg tgaccgataa caatggcgcc gtgaaatttc cccagctgtg caaattctgc      600

gatgtgaggt tttccacctg cgacaaccag aagtcctgta tgagcaactg ctccatcacc      660

tccatctgtg agaagcctca ggaggtgtgc gtggctgtct ggcggaagaa tgacgagaat      720

atcaccctgg aaaccgtctg ccacgatccc aagctgccct accacgattt catcctggaa      780

gacgccgcca gccctaagtg catcatgaaa gagaaaaaga agcctggcga gacctttttc      840

atgtgctcct gcagcagcga cgaatgcaac gacaatatca tctttagcga ggaatacaat      900

accagcaacc ccgacattac atgcccccct cccatgagcg tggagcacgc cgacatctgg      960

gtgaagagct atagcctcta cagccgggag aggtatatct gtaacagcgg cttcaagagg     1020

aaggccggca ccagcagcct caccgagtgc gtgctgaata aggctaccaa cgtggctcac     1080

tggacaacac cctctttaaa gtgcatccgg ggcggtggag gatccggagg aggtggctcc     1140

ggcggcggag gatctcgcga gggtcccgag ctttcgcccg acgatcccgc cggcctcttg     1200

gacctgcggc agggcatgtt tgcgcagctg gtggcccaaa atgttctgct gatcgatggg     1260

cccctgagct ggtacagtga cccaggcctg gcaggcgtgt ccctgacggg gggcctgagc     1320

tacaaagagg acacgaagga gctggtggtg gccaaggctg gagtctacta tgtcttcttt     1380

caactagagc tgcggcgcgt ggtggccggc gagggctcag gctccgtttc acttgcgctg     1440

cacctgcagc cactgcgctc tgctgctggg gccgccgccc tggctttgac cgtggacctg     1500

ccacccgcct cctccgaggc tcggaactcg gccttcggtt tccagggccg cttgctgcac     1560

ctgagtgccg gccagcgcct gggcgtccat cttcacactg aggccagggc acgccatgcc     1620

tggcagctta cccagggcgc cacagtcttg ggactcttcc gggtgacccc cgaaatccca     1680

gccggactcc cttcaccgag gtcggaa                                         1707


<210> 217
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL-18/IL-15RalphaSu sequence"

<400> 217
atgaagtggg tcacatttat ctctttactg ttcctcttct ccagcgccta cagctacttc       60

ggcaaactgg aatccaagct gagcgtgatc cggaatttaa acgaccaagt tctgtttatc      120

gatcaaggta accggcctct gttcgaggac atgaccgact ccgattgccg ggacaatgcc      180

ccccggacca tcttcattat ctccatgtac aaggacagcc agccccgggg catggctgtg      240

acaattagcg tgaagtgtga gaaaatcagc actttatctt gtgagaacaa gatcatctcc      300

tttaaggaaa tgaacccccc cgataacatc aaggacacca agtccgatat catcttcttc      360

cagcggtccg tgcccggtca cgataacaag atgcagttcg aatcctcctc ctacgagggc      420

tactttttag cttgtgaaaa ggagagggat ttattcaagc tgatcctcaa gaaggaggac      480

gagctgggcg atcgttccat catgttcacc gtccaaaacg aggatattac atgcccccct      540

cccatgagcg tggagcacgc cgacatctgg gtgaagagct atagcctcta cagccgggag      600

aggtatatct gtaacagcgg cttcaagagg aaggccggca ccagcagcct caccgagtgc      660

gtgctgaata aggctaccaa cgtggctcac tggacaacac cctctttaaa gtgcatccgg      720


<210> 218
<211> 2607
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL-12/TF/IL-15 sequence"

<400> 218
atgaaatggg tgacctttat ttctttactg ttcctcttta gcagcgccta ctccatttgg       60

gaactgaaga aggacgtcta cgtggtcgaa ctggactggt atcccgatgc tcccggcgaa      120

atggtggtgc tcacttgtga cacccccgaa gaagacggca tcacttggac cctcgatcag      180

agcagcgagg tgctgggctc cggaaagacc ctcacaatcc aagttaagga gttcggagac      240

gctggccaat acacatgcca caagggaggc gaggtgctca gccattcctt attattatta      300

cacaagaagg aagacggaat ctggtccacc gacattttaa aagatcagaa ggagcccaag      360

aataagacct ttttaaggtg tgaggccaaa aactacagcg gtcgtttcac ttgttggtgg      420

ctgaccacca tttccaccga tttaaccttc tccgtgaaaa gcagccgggg aagctccgac      480

cctcaaggtg tgacatgtgg agccgctacc ctcagcgctg agagggttcg tggcgataac      540

aaggaatacg agtacagcgt ggagtgccaa gaagatagcg cttgtcccgc tgccgaagaa      600

tctttaccca ttgaggtgat ggtggacgcc gtgcacaaac tcaagtacga gaactacacc      660

tcctccttct ttatccggga catcattaag cccgatcctc ctaagaattt acagctgaag      720

cctctcaaaa atagccggca agttgaggtc tcttgggaat atcccgacac ttggagcaca      780

ccccacagct acttctcttt aaccttttgt gtgcaagttc aaggtaaaag caagcgggag      840

aagaaagacc gggtgtttac cgacaaaacc agcgccaccg tcatctgtcg gaagaacgcc      900

tccatcagcg tgagggctca agatcgttat tactccagca gctggtccga gtgggccagc      960

gtgccttgtt ccggcggtgg aggatccgga ggaggtggct ccggcggcgg aggatctcgt     1020

aacctccccg tggctacccc cgatcccgga atgttccctt gtttacacca cagccagaat     1080

ttactgaggg ccgtgagcaa catgctgcag aaagctaggc agactttaga attttaccct     1140

tgcaccagcg aggagatcga ccatgaagat atcaccaagg acaagacatc caccgtggag     1200

gcttgtttac ctctggagct gacaaagaac gagtcttgtc tcaactctcg tgaaaccagc     1260

ttcatcacaa atggctcttg tttagcttcc cggaagacct cctttatgat ggctttatgc     1320

ctcagctcca tctacgagga tttaaagatg taccaagtgg agttcaagac catgaacgcc     1380

aagctgctca tggaccctaa acggcagatc tttttagacc agaacatgct ggctgtgatt     1440

gatgagctga tgcaagcttt aaacttcaac tccgagaccg tccctcagaa gtcctccctc     1500

gaggagcccg atttttacaa gacaaagatc aaactgtgca ttttactcca cgcctttagg     1560

atccgggccg tgaccattga ccgggtcatg agctatttaa acgccagcag cggcacaacc     1620

aacacagtcg ctgcctataa cctcacttgg aagagcacca acttcaaaac catcctcgaa     1680

tgggaaccca aacccgttaa ccaagtttac accgtgcaga tcagcaccaa gtccggcgac     1740

tggaagtcca aatgtttcta taccaccgac accgagtgcg atctcaccga tgagatcgtg     1800

aaagatgtga aacagaccta cctcgcccgg gtgtttagct accccgccgg caatgtggag     1860

agcactggtt ccgctggcga gcctttatac gagaacagcc ccgaatttac cccttacctc     1920

gagaccaatt taggacagcc caccatccaa agctttgagc aagttggcac aaaggtgaat     1980

gtgacagtgg aggacgagcg gactttagtg cggcggaaca acacctttct cagcctccgg     2040

gatgtgttcg gcaaagattt aatctacaca ctgtattact ggaagtcctc ttcctccggc     2100

aagaagacag ctaaaaccaa cacaaacgag tttttaatcg acgtggataa aggcgaaaac     2160

tactgtttca gcgtgcaagc tgtgatcccc tcccggaccg tgaataggaa aagcaccgat     2220

agccccgttg agtgcatggg ccaagaaaag ggcgagttcc gggagaactg ggtgaacgtc     2280

atcagcgatt taaagaagat cgaagattta attcagtcca tgcatatcga cgccacttta     2340

tacacagaat ccgacgtgca cccctcttgt aaggtgaccg ccatgaaatg ttttttactg     2400

gagctgcaag ttatctcttt agagagcgga gacgctagca tccacgacac cgtggagaat     2460

ttaatcattt tagccaataa ctctttatcc agcaacggca acgtgacaga gtccggctgc     2520

aaggagtgcg aagagctgga ggagaagaac atcaaggagt ttctgcaatc ctttgtgcac     2580

attgtccaga tgttcatcaa tacctcc                                         2607


<210> 219
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL-18/IL-15RalphaSu sequence"

<400> 219
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn 
            20                  25                  30          


Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe 
        35                  40                  45              


Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile 
    50                  55                  60                  


Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val 
65                  70                  75                  80  


Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn 
                85                  90                  95      


Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp 
            100                 105                 110         


Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp 
        115                 120                 125             


Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala 
    130                 135                 140                 


Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp 
145                 150                 155                 160 


Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


<210> 220
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL-12/TF/IL-15 sequence"

<400> 220
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp 
            20                  25                  30          


Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr 
        35                  40                  45              


Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val 
    50                  55                  60                  


Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp 
65                  70                  75                  80  


Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser 
                85                  90                  95      


Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile 
            100                 105                 110         


Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu 
        115                 120                 125             


Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile 
    130                 135                 140                 


Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp 
145                 150                 155                 160 


Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val 
                165                 170                 175     


Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp 
            180                 185                 190         


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val 
        195                 200                 205             


Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
    210                 215                 220                 


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
            260                 265                 270         


Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp 
        275                 280                 285             


Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val 
    290                 295                 300                 


Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
305                 310                 315                 320 


Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            340                 345                 350         


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        355                 360                 365             


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    370                 375                 380                 


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
385                 390                 395                 400 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                405                 410                 415     


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            420                 425                 430         


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
        435                 440                 445             


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    450                 455                 460                 


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
465                 470                 475                 480 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                485                 490                 495     


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            500                 505                 510         


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        515                 520                 525             


Val Met Ser Tyr Leu Asn Ala Ser Ser Gly Thr Thr Asn Thr Val Ala 
    530                 535                 540                 


Ala Tyr Asn Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu 
545                 550                 555                 560 


Trp Glu Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr 
                565                 570                 575     


Lys Ser Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu 
            580                 585                 590         


Cys Asp Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu 
        595                 600                 605             


Ala Arg Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser 
    610                 615                 620                 


Ala Gly Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu 
625                 630                 635                 640 


Glu Thr Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly 
                645                 650                 655     


Thr Lys Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg 
            660                 665                 670         


Asn Asn Thr Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile 
        675                 680                 685             


Tyr Thr Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala 
    690                 695                 700                 


Lys Thr Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn 
705                 710                 715                 720 


Tyr Cys Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg 
                725                 730                 735     


Lys Ser Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu 
            740                 745                 750         


Phe Arg Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
        755                 760                 765             


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
    770                 775                 780                 


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
785                 790                 795                 800 


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
                805                 810                 815     


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
            820                 825                 830         


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
        835                 840                 845             


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
    850                 855                 860                 


Phe Ile Asn Thr Ser 
865                 


<210> 221
<211> 1452
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL-21/TF mutant/IL-15 sequence"

<400> 221
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tcctccggca ccaccaatac cgtggccgct      480

tataacctca catggaagag caccaacttc gcgacagctc tggaatggga acccaagccc      540

gtcaatcaag tttacaccgt gcagatctcc accaaatccg gagactggaa gagcaagtgc      600

ttctacacaa cagacaccga gtgtgcttta accgacgaaa tcgtcaagga cgtcaagcaa      660

acctatctgg ctcgggtctt ttcctacccc gctggcaatg tcgagtccac cggctccgct      720

ggcgagcctc tctacgagaa ttcccccgaa ttcacccctt atttagagac caatttaggc      780

cagcctacca tccagagctt cgagcaagtt ggcaccaagg tgaacgtcac cgtcgaggat      840

gaaaggactt tagtggcgcg gaataacaca gctttatccc tccgggatgt gttcggcaaa      900

gacctcatct acacactgta ctattggaag tccagctcct ccggcaaaaa gaccgctaag      960

accaacacca acgagttttt aattgacgtg gacaaaggcg agaactactg cttcagcgtg     1020

caagccgtga tcccttctcg taccgtcaac cggaagagca cagattcccc cgttgagtgc     1080

atgggccaag aaaagggcga gttccgggag aactgggtga acgtcatcag cgatttaaag     1140

aagatcgaag atttaattca gtccatgcat atcgacgcca ctttatacac agaatccgac     1200

gtgcacccct cttgtaaggt gaccgccatg aaatgttttt tactggagct gcaagttatc     1260

tctttagaga gcggagacgc tagcatccac gacaccgtgg agaatttaat cattttagcc     1320

aataactctt tatccagcaa cggcaacgtg acagagtccg gctgcaagga gtgcgaagag     1380

ctggaggaga agaacatcaa ggagtttctg caatcctttg tgcacattgt ccagatgttc     1440

atcaatacct cc                                                         1452


<210> 222
<211> 483
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      IL-21/TF mutant/IL-15 sequence"

<400> 222
Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala Tyr 
1               5                   10                  15      


Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp 
            20                  25                  30          


Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe 
        35                  40                  45              


Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe 
    50                  55                  60                  


Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn 
65                  70                  75                  80  


Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro 
                85                  90                  95      


Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser 
            100                 105                 110         


Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 
        115                 120                 125             


Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr 
    130                 135                 140                 


His Gly Ser Glu Asp Ser Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr 
145                 150                 155                 160 


Asn Leu Thr Trp Lys Ser Thr Asn Phe Ala Thr Ala Leu Glu Trp Glu 
                165                 170                 175     


Pro Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser 
            180                 185                 190         


Gly Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Ala 
        195                 200                 205             


Leu Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg 
    210                 215                 220                 


Val Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly 
225                 230                 235                 240 


Glu Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr 
                245                 250                 255     


Asn Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys 
            260                 265                 270         


Val Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Ala Arg Asn Asn 
        275                 280                 285             


Thr Ala Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr 
    290                 295                 300                 


Leu Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr 
305                 310                 315                 320 


Asn Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys 
                325                 330                 335     


Phe Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser 
            340                 345                 350         


Thr Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg 
        355                 360                 365             


Glu Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
    370                 375                 380                 


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
385                 390                 395                 400 


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
                405                 410                 415     


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
            420                 425                 430         


Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
        435                 440                 445             


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
    450                 455                 460                 


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
465                 470                 475                 480 


Asn Thr Ser 
            


<210> 223
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Signal sequence"

<400> 223
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210> 224
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Linker sequence"

<400> 224
Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210> 225
<211> 1245
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21s137L sequence"

<400> 225
atgaagtggg tgaccttcat cagcctgctg ttcctgttct ccagcgccta ctcccagggc       60

caggacaggc acatgatccg gatgaggcag ctcatcgaca tcgtcgacca gctgaagaac      120

tacgtgaacg acctggtgcc cgagtttctg cctgcccccg aggacgtgga gaccaactgc      180

gagtggtccg ccttctcctg ctttcagaag gcccagctga agtccgccaa caccggcaac      240

aacgagcgga tcatcaacgt gagcatcaag aagctgaagc ggaagcctcc ctccacaaac      300

gccggcagga ggcagaagca caggctgacc tgccccagct gtgactccta cgagaagaag      360

ccccccaagg agttcctgga gaggttcaag tccctgctgc agaagatgat ccatcagcac      420

ctgtcctcca ggacccacgg ctccgaggac tccattacat gcccccctcc catgagcgtg      480

gagcacgccg acatctgggt gaagagctat agcctctaca gccgggagag gtatatctgt      540

aacagcggct tcaagaggaa ggccggcacc agcagcctca ccgagtgcgt gctgaataag      600

gctaccaacg tggctcactg gacaacaccc tctttaaagt gcatccgggg cggtggagga      660

tccggaggag gtggctccgg cggcggagga tctcgcgagg gtcccgagct ttcgcccgac      720

gatcccgccg gcctcttgga cctgcggcag ggcatgtttg cgcagctggt ggcccaaaat      780

gttctgctga tcgatgggcc cctgagctgg tacagtgacc caggcctggc aggcgtgtcc      840

ctgacggggg gcctgagcta caaagaggac acgaaggagc tggtggtggc caaggctgga      900

gtctactatg tcttctttca actagagctg cggcgcgtgg tggccggcga gggctcaggc      960

tccgtttcac ttgcgctgca cctgcagcca ctgcgctctg ctgctggggc cgccgccctg     1020

gctttgaccg tggacctgcc acccgcctcc tccgaggctc ggaactcggc cttcggtttc     1080

cagggccgct tgctgcacct gagtgccggc cagcgcctgg gcgtccatct tcacactgag     1140

gccagggcac gccatgcctg gcagcttacc cagggcgcca cagtcttggg actcttccgg     1200

gtgacccccg aaatcccagc cggactccct tcaccgaggt cggaa                     1245


<210> 226
<211> 415
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      21s137L sequence"

<400> 226
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp 
225                 230                 235                 240 


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                245                 250                 255     


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            260                 265                 270         


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        275                 280                 285             


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    290                 295                 300                 


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
305                 310                 315                 320 


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                325                 330                 335     


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            340                 345                 350         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        355                 360                 365             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    370                 375                 380                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
385                 390                 395                 400 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                405                 410                 415 


