                         SEQUENCE LISTING

<110>  The Penn State Research Foundation
 
<120>  COMPOSITIONS AND METHODS FOR USE IN CONTROLLING MOSQUITO-BORNE 
       VIRUSES

<130>  074339.00149

<150>  62/724,468
<151>  2018-08-29

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  2053
<212>  PRT
<213>  Aedes aegypti

<400>  1

Met Ile Ala Ser Thr Gln Lys Gln Gln Gln Arg Trp Thr Val Leu Ile 
1               5                   10                  15      


Pro Leu Leu Thr Ile Gly Phe Leu Ile Arg Thr Cys His Cys Asn Leu 
            20                  25                  30          


Pro Pro Ile Phe Thr Gln Asp Met Asn Asn Leu Ala Leu Pro Glu Thr 
        35                  40                  45              


Thr Pro Val Gly Ser Val Val Tyr Arg Leu Glu Gly Tyr Asp Pro Glu 
    50                  55                  60                  


Gly Gly Asn Val Ser Phe Gly Leu Leu Gly Ser Asp Asn Phe Met Val 
65                  70                  75                  80  


Asp Pro Ile Ser Gly Asp Val Lys Val Ile Lys Pro Leu Asp Arg Glu 
                85                  90                  95      


Asp Gln Asp Thr Leu Ser Phe Ser Val Thr Ile Lys Asp Arg Ile Ser 
            100                 105                 110         


Thr Ala Gly Ile Asp Ser Glu Asn Asp Asn Val Val Asn Val Pro Ile 
        115                 120                 125             


Thr Ile Ile Val Leu Asp Glu Asn Asp Asn Pro Pro Glu Phe Arg Asn 
    130                 135                 140                 


Val Pro Tyr Glu Thr Glu Val Leu Glu Asp Ala Lys Pro Gly Thr Thr 
145                 150                 155                 160 


Val Phe Ser Asp Ile Leu Val Thr Asp Arg Asp Thr Val Gly Asp Asn 
                165                 170                 175     


Leu Ile Val Asn Cys Ile Pro Gln Pro Gln Asn Pro Asp Ala Cys Glu 
            180                 185                 190         


Lys Phe Ala Ile Glu Thr Leu Glu Ser Gly Gln Asp Arg Leu Thr Ala 
        195                 200                 205             


Ser Val Val Leu Lys Gly Arg Leu Asp Tyr Asn Glu Arg Met Ile Tyr 
    210                 215                 220                 


Gln Ile Leu Leu Glu Ala Thr Asp Gly Met Phe Asn Ala Thr Ala Gly 
225                 230                 235                 240 


Leu Glu Ile His Val Lys Asp Val Gln Asn Ser Ala Pro Val Phe Gln 
                245                 250                 255     


Gly Ser Leu Ala Ala Val Ile Asn Glu Asp Ser Lys Ile Gly Thr Leu 
            260                 265                 270         


Val Met Met Ile His Ala Arg Asp Gly Asp Arg Gly Gln Pro Arg Lys 
        275                 280                 285             


Ile Val Tyr Glu Leu Val Thr Asn Pro Met Asp Tyr Phe Leu Leu Asp 
    290                 295                 300                 


Arg Gln Thr Gly Glu Leu Arg Thr Ala Lys Pro Leu Asp Lys Glu Ala 
305                 310                 315                 320 


Leu Pro Asp Asp Thr Gly Leu Ile Ile Leu Thr Val Lys Ala Arg Glu 
                325                 330                 335     


Leu Ile Asp Gly Val Pro Gly Asn Asp Asn Leu Thr Thr Ala Thr Thr 
            340                 345                 350         


Gln Ala Ser Ile Thr Ile Arg Asp Val Asn Asp Ser Pro Pro Met Phe 
        355                 360                 365             


Asn Lys Lys Glu Tyr Phe Val Ser Leu Ser Glu Asn Thr Ala Pro Gly 
    370                 375                 380                 


Thr Pro Leu Pro Ile Glu Met Ser Val His Asp Pro Asp Val Gly Glu 
385                 390                 395                 400 


Asn Ala Val Phe Ser Leu Arg Leu Asn Asp Val Ser Glu Val Phe Asp 
                405                 410                 415     


Val Glu Pro Lys Leu Val Thr Gly Ser Ser Gln Ile Ser Ile Arg Val 
            420                 425                 430         


Ala Asn Gly Ser Leu Asp Tyr Glu Asn Pro Asn Gln Arg Lys Phe Ile 
        435                 440                 445             


Val Leu Val Ile Ala Glu Glu Thr Gln Thr Asn Pro Lys Leu Ser Ser 
    450                 455                 460                 


Thr Ala Thr Leu Thr Val Ser Ile Thr Asp Ser Asn Asp Asn Arg Pro 
465                 470                 475                 480 


Ile Phe Glu Gln Asp Ser Tyr Ser Thr Thr Val Ser Glu Thr Ala His 
                485                 490                 495     


Pro Gly His Leu Ile Thr Thr Ile Thr Ala Arg Asp Leu Asp Ser Gly 
            500                 505                 510         


His Phe Gly Asp Gln Gly Ile Arg Tyr Ser Leu Ser Gly Thr Gly Ala 
        515                 520                 525             


Glu Leu Phe Asn Val Asp Pro Ile Thr Gly Ala Ile Thr Val Ala Asp 
    530                 535                 540                 


Cys Pro Ser Val Asp Asn Asp Asn Asn Lys Arg Arg Arg Arg Arg Arg 
545                 550                 555                 560 


Gln Ile Pro Ser Ser Asp Glu Leu Thr Gln Asp Tyr Pro Asp Met Lys 
                565                 570                 575     


Arg Phe Asn Val Ser Thr Asp Gly Arg Ser Gly Val Leu Asp Arg Gly 
            580                 585                 590         


Val Asp Tyr Met Ala Tyr Lys Ile Tyr Asn Ser Gly Glu Ser Asn Glu 
        595                 600                 605             


Tyr Arg Asp Val Asn Val Val Ala Pro Pro Thr Val Ser Ser Ser Trp 
    610                 615                 620                 


Glu Thr Ser Ser Leu Glu Glu Ser Asp Ser Thr Pro Ala Ile Glu Ser 
625                 630                 635                 640 


Glu Glu Tyr Phe Thr Pro Ser Ser Thr Thr Thr Pro Ile His Ser Asn 
                645                 650                 655     


Glu Ile Gln His Arg Ser Asp Val Gly Pro Gly Arg Ala Pro Cys Leu 
            660                 665                 670         


Asp Tyr Glu Asn Gln Ser Val Tyr Tyr Leu Ser Tyr Lys Ala Thr Asp 
        675                 680                 685             


Asp Glu Gly Arg Gly Gln Thr Ser Val Val Ser Leu Arg Ile Thr Leu 
    690                 695                 700                 


Leu Asp Ala Asn Asp Ser Pro Pro Val Cys Glu Ser Pro Leu Tyr Arg 
705                 710                 715                 720 


Ala Ser Val Asp Glu Gly Ala Thr Leu Phe Glu Pro Pro Leu Val Ile 
                725                 730                 735     


Lys Ala Arg Asp Pro Asp Val Ile Ser Glu Ile Asn Tyr Arg Ile Ile 
            740                 745                 750         


Gly Asn Glu Ala Ile Thr Arg His Phe Glu Ile Asp Lys Arg Ser Gly 
        755                 760                 765             


Gln Leu Thr Ile Ser Lys Ser Thr Ala Leu Asp Val Asn His Leu Lys 
    770                 775                 780                 


Ser Glu Asn Val Phe Phe Ala Val Glu Ala Ser Asp Gly Leu Phe Thr 
785                 790                 795                 800 


Thr Leu Cys Asn Val Asn Ile Thr Ile Arg Asp Val Asn Asn His Ala 
                805                 810                 815     


Pro Gln Phe Ser Arg Glu His Tyr Leu Ala Ser Ile Glu Glu Asn Phe 
            820                 825                 830         


Pro Ile Gly Thr Arg Val Glu Arg Leu Gln Ala Ile Asp Leu Asp Thr 
        835                 840                 845             


Gly Ile Asn Ala Glu Ile Arg Tyr Arg Ile Gln Gln Gly Ser Phe Asp 
    850                 855                 860                 


Asp Phe Ala Ile Asp Asn Gln Thr Gly Val Val Thr Ile Ala Arg Lys 
865                 870                 875                 880 


Leu Asp Tyr Asp Arg Arg Asn Thr Tyr Gln Met Glu Ile Val Ala Ala 
                885                 890                 895     


Asp Leu Gly Thr Pro Ser Leu Ser Gly Thr Thr Thr Leu Thr Val Ser 
            900                 905                 910         


Ile Ile Asn Ser Asn Asp Lys Ala Pro Tyr Phe Thr Pro Thr Thr Gln 
        915                 920                 925             


Arg Ala Glu Ile Ser Glu Asp Ala Glu Val Gly Thr Leu Val His Thr 
    930                 935                 940                 


Leu Val Ala Leu Asp Pro Asp Val Ala Ser Ser Glu Ala Leu Asp Tyr 
945                 950                 955                 960 


Ala Ala Thr Glu Pro Ile Thr Ala Val Asp Lys Asp Gly Lys Glu Val 
                965                 970                 975     


Arg Asp Thr Glu Asp Phe Lys Asp Met Phe Arg Ile Asp Arg Thr Gly 
            980                 985                 990         


Lys Val Phe Val Asn Arg Lys Leu  Gln Arg Asp Asp Phe  Ala Val Ile 
        995                 1000                 1005             


Arg Ile  Thr Val Leu Val Thr  Asp Thr Thr Ala Pro  Ser Ile Gln 
    1010                 1015                 1020             


Gln Gly  Glu Gly Leu Leu Ile  Ile Thr Ile Ile Asp  Val Asn Glu 
    1025                 1030                 1035             


Glu Pro  Pro Leu Phe Val Pro  Pro Trp Thr Pro Ala  Asp Pro Arg 
    1040                 1045                 1050             


Tyr Arg  Phe Gln Val Leu Glu  Glu Gln Pro Ile Gly  Thr Ile Leu 
    1055                 1060                 1065             


Thr Thr  Met Gln Ala Thr Asp  Ala Asp Ser Thr Val  Ala Glu Tyr 
    1070                 1075                 1080             


Arg Met  Thr Asp Asn Ser His  Phe Glu Ile Asn Asn  Thr Thr Gly 
    1085                 1090                 1095             


Leu Ile  Arg Thr Lys Ala Arg  Ile Asp Tyr Glu Gln  Thr Pro Thr 
    1100                 1105                 1110             


Ile Gln  Phe Asn Val Thr Val  Val Asp Thr Gly Ile  Pro Gln Leu 
    1115                 1120                 1125             


Thr Ser  Thr Ala Glu Val Thr  Val Asp Ile Ile Asn  Thr Asn Asp 
    1130                 1135                 1140             


Asn Asp  Pro Ala Phe Asp Glu  Pro Glu Tyr Glu Met  Ser Val Val 
    1145                 1150                 1155             


Glu Asn  Ala Pro Thr Gly Thr  Val Val Gly Ile Val  Ser Ala Arg 
    1160                 1165                 1170             


Asp Ala  Asp Ser Gly Pro Tyr  Gly Gln Ile Thr Tyr  Ser Leu Val 
    1175                 1180                 1185             


Gly Asp  His Ser Ala Ala Ser  Phe Ala Ile Asp Pro  Asp Thr Gly 
    1190                 1195                 1200             


Val Ile  Thr Val Arg Asp Gly  Thr Thr Leu Asp Arg  Glu Arg Thr 
    1205                 1210                 1215             


Thr Glu  Ile Gly Leu Thr Ala  Ile Ala Thr Asp Arg  Ala Pro Asp 
    1220                 1225                 1230             


Gly Thr  Ser Arg Ser Thr Thr  Ala Pro Val Thr Ile  Lys Leu Leu 
    1235                 1240                 1245             


Asp Glu  Asn Asp Asn Val Pro  Thr Phe Ser Gln Lys  Ile Tyr His 
    1250                 1255                 1260             


Ala Thr  Val Ala Glu Asn Ala  Ala Leu Asn Pro Pro  Ala Ala Ile 
    1265                 1270                 1275             


Leu Gln  Val Leu Ala Thr Asp  Pro Asp Glu Gly Ala  Ala Gly Asp 
    1280                 1285                 1290             


Val Lys  Tyr Ser Ile Ile Gly  Ser Asp Ile Glu Asn  Thr Phe Arg 
    1295                 1300                 1305             


Leu Asp  Ala Asn Ser Gly Ile  Leu Tyr Pro Tyr Ala  Ser Leu Leu 
    1310                 1315                 1320             


Gly Leu  Asp Gly Asn Tyr Arg  Ile Gln Ile Glu Ala  Arg Asp Gly 
    1325                 1330                 1335             


Leu Gly  Ser Gly Pro His Ser  Asp Arg Ala Glu Ile  Lys Ile Glu 
    1340                 1345                 1350             


Ile Gln  Ser Ile Asn Gln His  Arg Pro Ile Phe Ile  Met Pro Ala 
    1355                 1360                 1365             


Leu Ser  Asn Ala Thr Val Glu  Ile Pro Glu Asn Leu  Ala Met Thr 
    1370                 1375                 1380             


Asp Tyr  Leu Val Met Thr Val  Lys Ala Asn Asp Ser  Asp Glu Gly 
    1385                 1390                 1395             


Thr Asn  Gly Lys Val Leu Tyr  His Leu Gln Val Asn  Asn Gln Asn 
    1400                 1405                 1410             


Val Gln  Glu Thr Asp Glu Phe  Ile Ile Asn Glu Met  Ser Gly Glu 
    1415                 1420                 1425             


Leu Arg  Ile Arg Lys Pro Leu  Asn Arg Lys Lys Gln  Ala Arg Phe 
    1430                 1435                 1440             


Glu Leu  Ile Leu Val Ala Arg  Asp Gln Gly Thr Pro  Ala Trp Phe 
    1445                 1450                 1455             


Glu Thr  Leu Arg Phe Leu Thr  Val Leu Leu Val Asp  Val Asn Glu 
    1460                 1465                 1470             


Asn His  Pro Glu Phe Pro Asp  Ala Ser Asn Pro Tyr  Arg Phe Phe 
    1475                 1480                 1485             


Ile Ala  Glu Asn Ser Pro Arg  Asp Ile Arg Ile Gly  Lys Ile Gln 
    1490                 1495                 1500             


Ala Tyr  Tyr Asp Thr Pro Asp  Pro Lys Ile Tyr Tyr  Tyr Met Met 
    1505                 1510                 1515             


Leu Gly  Asn Glu Asp Gly Ala  Phe Tyr Val Asp Lys  Thr Thr Gly 
    1520                 1525                 1530             


Asp Ile  Tyr Thr Asn Lys Thr  Leu Asp Arg Glu Glu  Ala Asp Val 
    1535                 1540                 1545             


Tyr Ala  Leu Tyr Ile Lys Ala  Ser Lys Lys Gln Asp  Leu Leu Ile 
    1550                 1555                 1560             


Thr Glu  Arg Asp Arg Met Met  Met Ser Thr Lys Lys  Leu Glu Arg 
    1565                 1570                 1575             


Asp Ser  Thr Val Ala Lys Val  Trp Ile Thr Val Leu  Asp Val Asn 
    1580                 1585                 1590             


Asp Asn  Pro Pro Val Phe Lys  Gln Asp Val Tyr Tyr  Ala Gly Val 
    1595                 1600                 1605             


Ser Ser  Lys Ala Ala Ile Asn  Glu Leu Val Thr Ile  Val Asn Ala 
    1610                 1615                 1620             


Thr Asp  Arg Asp Leu Gly Val  Asn Ser Thr Met Glu  Leu Phe Ile 
    1625                 1630                 1635             


Ser Gly  Ser Tyr Leu Tyr Lys  Tyr Gly Ala Thr Lys  Thr Thr Gly 
    1640                 1645                 1650             


Ser Ile  Val Pro Ser Pro Phe  Thr Ile Ser Lys Asp  Gly Arg Ile 
    1655                 1660                 1665             


Thr Thr  Ala Asn Tyr Met Ala  Glu Tyr Asn Gln Asp  Arg Phe Ile 
    1670                 1675                 1680             


Leu Asp  Ile Val Ala Lys Glu  Val Glu Ser Pro Glu  Arg Val Ala 
    1685                 1690                 1695             


Thr Thr  Lys Val Tyr Val Trp  Ile Phe Asn Pro Glu  Gln Leu Val 
    1700                 1705                 1710             


Arg Val  Ile Leu Ser Arg Pro  Pro Ser Glu Val His  Met Glu Arg 
    1715                 1720                 1725             


Asp Glu  Ile Ile Ser Glu Leu  Ser Asn Ala Thr Gln  Lys Leu Ile 
    1730                 1735                 1740             


Ile Val  Asp Glu Ile Arg Tyr  His Val Asp Ser Leu  Gly Arg Ile 
    1745                 1750                 1755             


Arg Met  Asp Trp Cys Asp Met  Tyr Phe His Ala Ile  Asp Met Ser 
    1760                 1765                 1770             


Ser Gln  Thr Ile Val Ser Val  Glu Glu Ile Leu Arg  Glu Ile Asp 
    1775                 1780                 1785             


Ala Lys  Tyr Asp Phe Leu Gln  Asp Tyr Asn Ala Gly  Phe Ser Ile 
    1790                 1795                 1800             


Glu Asn  Val Val Pro Ala Tyr  Ala Thr Asn Val Gln  Asp Glu Phe 
    1805                 1810                 1815             


Asp Leu  Ala Leu Ala Ala Ile  Ile Ala Leu Leu Ile  Val Leu Phe 
    1820                 1825                 1830             


Val Gly  Ala Val Ser Phe Ile  Val Leu Cys Cys Cys  Leu Lys His 
    1835                 1840                 1845             


Trp Val  Ile Thr Ile Pro Asn  Glu Thr Arg Arg Lys  Asp Ala Leu 
    1850                 1855                 1860             


Ile Lys  Lys Gln Ile Ile Glu  Asp Leu Asn Thr Thr  Glu Asn Pro 
    1865                 1870                 1875             


Leu Trp  Ile Glu Gln Lys Leu  Lys Leu Tyr Glu Glu  Gln Glu Leu 
    1880                 1885                 1890             


Thr Met  Gln Val Phe Ser Glu  Pro Glu Leu Thr Gln  Gln Gln Gln 
    1895                 1900                 1905             


Gln His  His His Gln Gln Gln  Leu Asn Ser Ser Asn  Asn Thr Ser 
    1910                 1915                 1920             


Ser Ser  Leu Ala Ser His Gln  Asn Gln His His His  Val Met Gln 
    1925                 1930                 1935             


Gln Gln  Glu Gln Ala Leu Val  Leu Gly Leu Asp Arg  Arg Asp Ser 
    1940                 1945                 1950             


Tyr Pro  Glu Leu Ser Gln Gly  Gly Gly Asp Asn Thr  Tyr Ala Thr 
    1955                 1960                 1965             


Ile Gln  Pro Arg Asn Tyr Ala  Ser Asn Leu Ser Ser  Val Leu Met 
    1970                 1975                 1980             


Gly Thr  Ser Gly Ile Gly Gly  Gly Gly Gly Gly Gly  Ser Gly Asn 
    1985                 1990                 1995             


Gly Ala  Ala Pro Ala Gly Gly  Leu Ser Gly Glu Met  Ser Asp Tyr 
    2000                 2005                 2010             


Ala Thr  Leu Arg Asn Ser Arg  Ala Pro Ser Met Tyr  Glu Phe Arg 
    2015                 2020                 2025             


Gly Ser  Thr Phe Gln Val Gln  Gln Leu Asn Gly Gly  Pro Gly Gly 
    2030                 2035                 2040             


Asp Gln  Pro Asp Tyr Val Thr  Glu Leu Ile 
    2045                 2050             


<210>  2
<211>  9594
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA encoding Cadherin protein

<400>  2
tagcaaaacg tagctgctcc gttggttcag actacagttg acgtcgcgat ttcaacccga       60

ttggattggc ttcccttcaa tccggacaaa aactcggaag aaacgtaaac gccgcttttc      120

gaacagagca tcttggttgc ttttggggcc tcgtgaagct cgtgtcgccg gatgagagga      180

tttggaaata cagcaacaat agcaggataa tctccatatc attggttgac tatggtagct      240

cgtcatcgct gtcgctggct cactggtgag caagggagga agcgtggtgg tgaataattc      300

gataggtgca attttcacgg tgattgctcg agtggtcgat tgagaaggac tggctgggaa      360

aaccggtttt ccaccaattc agtgtcgatt gtcgaaagaa accgacaaac agtatcgttg      420

ggttcgtttt gtgtggcgga gtgggttgag tgtctgatta gaaataaaag tggaagaata      480

tcatcactgg cagttatctg taactgattc gttgcaggcg tcggtaccgc acctggctcc      540

gcgaagcaat atcagctccg ctgttgatga aagttttgct ttaagttctt cagctccaag      600

tttctgttgt tgtttgcccg gttgttgttg tcagtgctgg tgtttctccc atccccggaa      660

accggtacca ttacataaag agcaaagttc ttcgccgtac acccaaggct tgcaaccgcg      720

aacacgatgc gatgctaaat cctaagccag tcttcgaggc gttccactag gacatttgtg      780

cctccttcgg gaaagtgatc tggcgtcgtc atgaatattt tatacgcgct acgacgagtg      840

tgcttcgctt ttgcgatttc ctgtcagtct gtgcaaaaat aatatcccac tcaatacaag      900

agcagaagca aaaagcccca cagtaagaaa aatagtagca aagcagcata tcataatagt      960

cgttaagaat aaagaaaata taattgaaac gtgtttccga gcgaaaaggg aaaaagtgtt     1020

gcctcggcga gagttgcaca aaaagtggag gaaattaaaa gaagctacta ttctcgtaac     1080

gaaaagccaa gaagcgtggt tggttgtgcg aaggaaaaag tgaatgattt attcagtgga     1140

tcgtctctcg ggttcgttgg aggaaacgtg taagagaaga gcagtcagca gcaaggtgaa     1200

gattgtgcga aaactgtaaa tcaagcggaa cgacgacggc gacgaatatg aatgcgaaag     1260

ttgaagtcga cggccaggtc gtcttcatca gcatcatcag agaagttgtg ggctgtagtg     1320

acgggtggtg taaagtgtag gagtctgctg gtaaagctga gttgtagtgg ttttgttttt     1380

atcaagaaag gattccaaga aagaagaaaa gaacatttaa ggagagtagt gtctttggcg     1440

tttggagctt tgccggtgcg gaacccaatt agagcagcta aagaaagatt catctttcgt     1500

aattcaatat ctctaaactg aacggaagtg aactagaatt gtgtgtgtgt ggcaaggacg     1560

accaggcgac gaagcagccg ccattcagca atgatagcct ccacccagaa gcagcaacag     1620

cgatggacag ttttaatacc gctcctaacg atagggttcc tgattcggac atgtcactgc     1680

aacctgccgc cgattttcac gcaggacatg aacaacttgg ccctgccgga gacaactccg     1740

gtgggaagcg tcgtttaccg gctggagggt tacgatccgg agggcggtaa cgtctcgttt     1800

gggctgctcg gctcggacaa ctttatggtg gacccaatca gtggggacgt caaggtgata     1860

aaaccgctgg accgtgagga ccaggacacc ctctccttct cggtgaccat caaggatcgc     1920

atcagcaccg caggaatcga ttccgagaac gacaacgtgg tcaacgttcc catcacgata     1980

atcgtcctgg acgaaaacga caacccaccg gaatttcgca atgttcccta cgaaacagag     2040

gtcctggagg acgccaagcc aggcaccacc gtgttcagcg atatcctggt taccgatcgg     2100

gacaccgtcg gagataacct gatcgtgaac tgtattccac aaccgcagaa cccggatgct     2160

tgcgaaaagt tcgccatcga aaccctcgaa agcggtcagg atcgactaac ggcttcggtg     2220

gtgctgaagg gtcgcctaga ctacaacgaa cggatgatct accagattct gctggaggct     2280

accgatggga tgttcaacgc cacggctgga ctggagatcc acgtgaagga tgttcagaac     2340

agtgcgccgg tgttccaagg atcgttggcg gcggtaatca acgaggacag caagatcggg     2400

acgctggtga tgatgatcca cgcaagggat ggcgatcggg gtcaaccgag gaagattgtc     2460

tacgaattag ttacgaaccc aatggattac ttcttgctgg atcgtcaaac gggtgagcta     2520

cgcacggcca aaccactcga caaggaagcc cttcccgacg acaccgggtt gataatcctg     2580

acggttaaag ctcgcgagct gatcgacgga gttcccggta atgacaatct gaccacggca     2640

acaacacaag cgtcgatcac gattcgcgat gtgaacgatt ctccaccgat gttcaacaaa     2700

aaggaatact tcgtatcgct gtcggagaat acggctccgg gaacgccact tccgatcgaa     2760

atgagcgttc atgatccgga tgttggagag aacgctgtgt tttctctacg cttgaatgat     2820

gtttcggaag tgttcgatgt ggagccaaaa ttggtgacgg gatcgtcaca gattagtatt     2880

cgtgtagcga atggttcgct ggattacgaa aaccctaacc aacggaagtt catcgtattg     2940

gtgatcgctg aagaaaccca gacgaaccct aagctgtcat cgacagctac tttaacggtg     3000

tctatcaccg actcgaatga caaccgtccg atcttcgagc aggactcgta ctctacaact     3060

gtatcggaaa ctgctcatcc cggtcatttg ataacgacca tcaccgccag agatctcgac     3120

tcaggtcatt tcggcgacca aggaattcgg tattccttgt ctggaacggg agccgaactc     3180

ttcaacgtcg acccgataac cggcgctata acggtcgctg attgcccatc cgtagacaac     3240

gacaacaaca aaagacgtcg tcggcgacgt cagattcctt catccgatga gctgactcaa     3300

gactacccgg atatgaaacg tttcaacgtg tcaaccgacg gacgttcggg cgtcctagac     3360

cgtggcgtag actatatggc ctacaagatc tacaacagtg gcgaatcgaa cgagtaccga     3420

gacgtgaatg tcgtcgcacc tccaacggtt tccagcagct gggaaacgtc cagtttggag     3480

gaaagcgact ccaccccggc catcgagtcg gaagaatact tcacgccatc tagcaccacc     3540

actcccatcc actcgaacga aatccagcac cgttcggatg tgggcccagg gcgagctcct     3600

tgcttggact acgaaaatca atcggtgtac tatctgtcct acaaggccac ggatgacgag     3660

ggccggggtc aaacgtcggt agtatcgctc cggatcaccc ttctggatgc gaacgattcg     3720

ccgccggtgt gcgagagccc tctctatagg gcatcggtcg acgagggagc caccctattt     3780

gagccgccgc tcgtcatcaa agcccgcgat ccggacgtta tttcggaaat taattatcgc     3840

ataattggta acgaagcaat tacgcgccat ttcgaaatcg acaaacggtc cggacagttg     3900

accatctcca agagtaccgc cctggacgtg aaccatctga agtcggaaaa cgtgttcttc     3960

gccgtggagg caagcgatgg cctcttcacc accctgtgca acgtgaacat caccatccgg     4020

gacgtgaaca accatgcacc gcagttctcc cgggagcact atcttgcctc gatcgaggag     4080

aacttcccga ttggcacccg agtcgaacgt ttacaggcaa tcgatttgga taccggcatc     4140

aacgccgaga tcaggtaccg catccagcag ggaagcttcg atgactttgc catcgacaac     4200

caaaccgggg tggtgaccat cgcccggaag ttggactacg accggaggaa cacctaccag     4260

atggaaatag tggcagcgga tctgggcacc ccaagtctgt cggggacaac caccctgacg     4320

gtgagcatca tcaatagcaa cgacaaagcc ccgtacttta cgccgactac tcagcgggcg     4380

gaaatatcgg aggatgcgga agtgggaacg ttggtccaca cgctggtggc actcgatccg     4440

gatgtggcgt ccagcgaagc gttggattat gcggcaacgg aacccatcac ggccgttgac     4500

aaggacggaa aggaggtgcg ggacacggaa gatttcaagg acatgttccg catcgatcgg     4560

accggaaagg tgttcgtcaa tcggaagctg cagcgggatg attttgcggt gatccgaatc     4620

acggttctgg taacggacac aaccgcccca tcgattcagc agggcgaagg tctcctcata     4680

atcacaatca tcgacgtaaa tgaagagcca ccgctgttcg tgcccccgtg gactccggcg     4740

gatccccgct accggttcca ggtgctggag gaacaaccga tcggtaccat cctgacgacg     4800

atgcaagcaa cagatgccga ctcgaccgtc gccgagtacc ggatgacaga taacagccat     4860

ttcgagataa acaacacaac aggtctgatc cgcaccaaag cccgtatcga ttacgagcaa     4920

acgccaacga tccagttcaa cgtcaccgtg gtggacaccg gaatcccgca gttgacgtcc     4980

accgccgaag taacggtcga catcatcaac accaacgaca acgatccggc cttcgacgag     5040

cctgagtacg aaatgtccgt cgtggaaaac gcacccaccg gaacggttgt gggcatagtt     5100

tcagcgcggg atgccgactc gggaccgtat ggccaaatca cctactccct ggtcggtgac     5160

cacagtgctg ccagctttgc catcgatcca gacaccggag ttatcacggt gcgcgacggc     5220

acaaccttgg accgtgaacg gacaacggaa atcggcctca ctgccattgc cacggatcgg     5280

gccccggatg gaaccagccg gtcgaccacc gcaccggtta ccatcaaact gctggacgag     5340

aacgacaatg tgccgacctt ctcgcagaag atttatcacg ccacggtagc ggaaaatgcg     5400

gcactcaatc caccggcagc aatcttgcag gttttggcca ccgatccgga cgagggcgct     5460

gctggggacg tgaaatatag catcatcggt agcgatattg aaaacacctt ccggctggac     5520

gcaaactcgg gcatcctgta tccgtacgcc agtttgctgg gactcgacgg caactatcgc     5580

atccaaatcg aggcccgcga tggcctagga tccggacctc acagcgatcg ggctgaaatt     5640

aaaattgaaa tacaaagcat caaccagcat cgtccgattt tcatcatgcc ggcactgtcc     5700

aacgcaacgg tggaaatccc cgagaattta gcgatgacgg attatctcgt gatgacggtt     5760

aaagcgaacg acagcgacga gggaacgaac ggcaaagttt tgtaccatct gcaggtcaac     5820

aaccagaacg tccaggaaac ggacgagttc atcatcaacg aaatgtccgg cgaactgcgc     5880

attcgcaagc ccctcaaccg caagaagcag gcccgcttcg agttgatcct ggtggcccgg     5940

gaccagggta cccctgcgtg gttcgaaacg ctccgtttcc tcaccgtact gctggtcgac     6000

gtcaacgaaa accacccgga gtttccggac gcctcaaacc cctacaggtt cttcatcgcc     6060

gagaacagtc ctcgggacat ccgcatcggt aaaatccagg cctattacga cacacccgac     6120

ccgaaaatct actactacat gatgctcggc aacgaggatg gagcgttcta cgtggacaaa     6180

accaccggcg atatctacac caacaaaacg ctggaccgcg aggaagcgga tgtctacgct     6240

ctctatatca aagccagcaa gaaacaagac ctgctgatca ctgagcgcga tcggatgatg     6300

atgtcgacca aaaagctgga acgcgatagc acggttgcga aggtctggat cacagtcctc     6360

gatgtcaacg acaatccccc ggtctttaaa caggacgttt actacgctgg cgtaagctcc     6420

aaggctgcca tcaacgaatt ggtgacaatt gtcaatgcga ccgatcgaga tctgggcgtg     6480

aactctacca tggaactgtt catcagcggg tcttatcttt acaaatacgg agctacgaag     6540

acaactggta gcatagttcc aagtccgttc actatttcca aggacggtcg tataactacc     6600

gcaaactaca tggccgaata taaccaggac cgtttcattc tggacattgt agcaaaagag     6660

gtggaatctc ctgagcgagt tgccaccacc aaagtctacg tctggatctt caatccagaa     6720

caactagtgc gtgtgatcct gtcgaggcca ccctcggaag ttcacatgga gcgagatgag     6780

atcatatccg aactttcgaa tgccacccag aagctgatta ttgtcgatga gattcgatac     6840

cacgtggaca gcttgggtcg cattcggatg gattggtgcg acatgtactt ccatgcgatc     6900

gatatgagtt cgcagacgat cgtgtcggta gaggagattc tgcgggagat cgacgccaaa     6960

tatgatttcc tacaggatta caatgccggc ttttcgatcg agaacgtagt cccggcctac     7020

gcaaccaacg tccaggacga gttcgatttg gccctggctg cgataatcgc cctgctgata     7080

gtgctgtttg tcggtgccgt aagcttcatc gtcctgtgct gctgtctcaa acattgggtc     7140

attacgattc cgaacgaaac cagaagaaag gacgccttga tcaaaaagca gattatcgaa     7200

gatttaaata cgaccgagaa tccactttgg atcgagcaaa aactgaagct ctacgaagag     7260

caggaactga cgatgcaagt gttttccgag ccggaactga cgcaacagca gcagcagcac     7320

caccaccaac agcagttgaa cagctcgaac aatacttcgt cgtcgttggc cagccaccag     7380

aaccagcacc accatgtgat gcaacagcag gaacaagcgt tggtcctggg gctggatcgg     7440

cgggattcgt acccggaatt gtcccaaggg ggcggcgata acacgtacgc caccatccag     7500

ccacgcaatt atgcgtccaa tctgagctcg gtgctgatgg gcactagcgg gattggtggc     7560

ggcggcggtg gcggaagcgg aaacggtgcg gccccggcag gcggactgag cggagaaatg     7620

tcggattatg cgacactgcg gaacagcagg gcaccctcga tgtacgagtt ccgaggttca     7680

accttccagg tacagcagct aaacggtgga cccggcggtg accagccaga ctacgtgacg     7740

gaactgattt aagagtaaac aaccttcgaa cagcatcgaa ccgttttgac ccaactcagc     7800

cccaaaagtg caacagtgga acaaaccgtt ttacgctctc gagatggaca gagaaagaga     7860

gagcaacatc actttttggg tttttagcat aggatatcat caggagacta gaaagcggtt     7920

tggaatttac aaaccaaccg gaatcgccgg attgccaatt tggatttgta gaaaatgaat     7980

gctcaatgtg tatgacaccc gaatgaaata ctcaagtgaa ggaaaagttc ggaaagcgat     8040

tttttaaatt actgatgaga ggcacagatt acaaaacact ctttgataga caataaatag     8100

gagatatctt aaaaggatag tatttatgac ggaggaagca acattgaaga gataaacgca     8160

cccggagaaa attgaatcat tccacacgcg tactcattcc gagtttaagt tgtaattaat     8220

ttaagttcac aaaaatacat taacagatga ccaccagaat cgaattcgag ctatcacgac     8280

ccgactcccc cttcatttaa aggtgctcga taggcaggga gcggacgagt ggccatttac     8340

ttcacttgga tacctcggcg gtctggggcc agcggccatt tcgagctcat tataatttct     8400

cccattttct gccaattacc aacgaacgtt cgctccacca cactctcaca cgtggtcggt     8460

accggcacgc gcttgagttc aacaaatgaa tgcaattaaa aattacgcaa aacgagattg     8520

ggggaaaaat tctgcgcacc aaaaggcatc aatgtgcaat ttttcgagag aggcaggaag     8580

aatatactga aagggataag aggtcgaatg tgtcgaaata gtcgaaatca agcatttttc     8640

gaatgggttt ccctacgaaa ggcggaaatc acgaaaggct caactcgtaa aagctgaaaa     8700

tatcaaaata ctgaatggta ttcaagtctt ctctagtaaa tctagtttct agatgtcatc     8760

ttgcaattca actagcccga atgacactaa cttgcaagca tcttatccga actttatgaa     8820

cattcagctt tttttgtttc ggccttaagt tggaatcctt cggatgttac ttttctaggg     8880

ttgcacagca tccagtgaac tgacaatggc agttgaagag gcacaattta ataattttga     8940

aaattactta caaattcgtt gacataaaaa aaactccgtg agctcactag aaaattgtaa     9000

aaaatgtcgt tttgatacaa cctgtatgaa aaatttgttt taactcaaaa cttattacga     9060

gtttcaaaat caattcagtt caaatcagca tcaaacgcct catttcgttc aatactcttt     9120

cgttgagaat atttgtctac cgttcgcatt tggaatacaa cttttatgta tttcgaccta     9180

aagaccattc gacctattat cgcgatgcga aacaaccccc aactgtgaag tgaatatcag     9240

cgcgtgtcgt tcgaaaaaaa aagactcaaa aatccaaccg ccgacgccaa accgtcgagg     9300

tatcgagagt cgaacattgt aaataattaa atctagcaaa atggatgaga atatttaaat     9360

tattaaaaat caattatgtt aacgagttta cagagacatg cgggagggtg agggcttcga     9420

acaagggtct gagggattgc atcgccctcg ggctttagtt tcgatagcca gcctcggtgc     9480

gataaaaaag ggctcgaccg atccaattca gcgagagcgt caagagtaac tgcccatttt     9540

gtgaaaggat tgaaaaagag gacgacgcta cgaaaggaca gctaccctct atcg           9594


<210>  3
<211>  1226
<212>  PRT
<213>  Aedes aegypti

<400>  3

Met Thr Val Lys Ile Phe Arg Arg Gly Ser Ala Arg Cys Ile Gly Leu 
1               5                   10                  15      


Leu Ser Ala Phe Val Thr Ile Leu Leu Cys Leu Tyr Tyr Ile Ser Met 
            20                  25                  30          


Gly Gln Pro Ser Asn Thr Pro Thr Thr Thr Ala Thr Ser Gly Gly Ser 
        35                  40                  45              


Ser Leu His Lys Asp Ala Ala Leu His Gln Lys Arg Leu Ser Asn Leu 
    50                  55                  60                  


His Ala Asp Pro His His Gly Ala Gly Ser Asn Pro Asn Ala Asn Gln 
65                  70                  75                  80  


Ser Trp His Ser Trp Leu Arg Asn Asn Leu Asn Ser Ile Asn Asn Gly 
                85                  90                  95      


Gly Asn Gly Lys Asp Arg Pro Pro Gly Leu Gly Pro Glu Val Ser Asp 
            100                 105                 110         


Ser Gly Gly Tyr Pro Asp Gly Asp Gly Gly Gly Gly Gly Val Gly Ala 
        115                 120                 125             


Ala Ala Ala Ala Val Ala Gly Ser His Pro Pro Arg Phe Ser Ala Lys 
    130                 135                 140                 


Trp Asp Glu Cys Val Ala Leu Glu Glu Thr Pro Thr Asp Ile Thr Thr 
145                 150                 155                 160 


Gly Asp Glu Tyr Gly Asn Phe Asp Phe Gln Pro Glu Trp Met Lys Thr 
                165                 170                 175     


Lys Glu Tyr Trp Asp Lys Asp Phe Glu Ser Arg Tyr Glu Lys Leu Gln 
            180                 185                 190         


Lys Asp Pro Asn Arg Pro Pro Leu Lys Ile Val Val Val Pro His Ser 
        195                 200                 205             


His Asn Asp Pro Gly Trp Leu Lys Thr Phe Val Asn Tyr Phe Gln Ser 
    210                 215                 220                 


Asp Ser Arg Gln Ile Leu Asn Leu Ala Val Thr Lys Met Pro Glu Tyr 
225                 230                 235                 240 


Asn Asn Met Ser Phe Ile Trp Ser Glu Ile Ser Phe Leu Gln Leu Trp 
                245                 250                 255     


Trp Asp Gln Ala His Pro Thr Lys Gln Arg Ile Leu Lys Lys Leu Val 
            260                 265                 270         


Lys Ser Gly Arg Leu Glu Ile Thr Thr Gly Gly Trp Val Met Thr Asp 
        275                 280                 285             


Glu Ala Asn Ala His Leu Tyr Ala Met Val Asp Gln Leu Ile Glu Gly 
    290                 295                 300                 


His Gln Trp Val Lys Thr Asn Leu Asn Val Thr Pro Lys Ser Gly Trp 
305                 310                 315                 320 


Ser Ile Asp Pro Phe Gly His Gly Ser Thr Val Pro Tyr Leu Leu Ala 
                325                 330                 335     


Ala Ser Gly Phe Glu Gly Thr Ile Ile Gln Arg Ile His Tyr Ala Trp 
            340                 345                 350         


Lys Gln Trp Phe Ala Arg His Arg Tyr Gly Asp Phe Leu Trp Ser Pro 
        355                 360                 365             


Tyr Trp Arg Thr Pro Ser Ser Gly Leu Asp Arg Lys His Thr Leu Leu 
    370                 375                 380                 


Thr His Asn Met Pro Phe Asp Ile Tyr Ser Ile Lys His Ser Cys Gly 
385                 390                 395                 400 


Pro His Pro Phe Ile Cys Leu Asn Phe Asp Phe Arg Lys Ile Pro Gly 
                405                 410                 415     


Glu Tyr Thr Glu Tyr Ser Ile Lys Ala Gln Phe Ile Thr Pro Glu Asn 
            420                 425                 430         


Ile Glu Ser Lys Ala Asp Leu Leu Met Glu Gln Tyr Ser Arg Thr Ala 
        435                 440                 445             


Ser Leu Phe Pro His Asn Val Ala Leu Ile Pro Val Gly Asp Asp Phe 
    450                 455                 460                 


Arg Tyr Asn Lys Asp Lys Glu Met Glu Gln Gln Tyr Thr Asn Tyr Lys 
465                 470                 475                 480 


Lys Leu Ile Asp Tyr Ile Asn Glu Asn Arg Asn Lys Tyr Lys Ala Glu 
                485                 490                 495     


Ile Ser Phe Gly Thr Pro Lys Asp Tyr Phe Asn Ala Ile Lys Glu Arg 
            500                 505                 510         


Tyr Asp Lys Phe Pro Thr Leu Lys Gly Asp Phe Phe Val Tyr Ala Asp 
        515                 520                 525             


Ile Phe Asn Glu Gly Arg Pro Ala Tyr Trp Ser Gly Tyr Phe Thr Thr 
    530                 535                 540                 


Arg Pro Tyr Tyr Lys Ile Leu Ser Arg Glu Leu Glu His Asn Leu Arg 
545                 550                 555                 560 


Ser Leu Glu Ile Leu Phe Thr Leu Ala Phe Asn Arg Ala Arg Gln Ala 
                565                 570                 575     


Gly Asn Ser Asn Ala Phe Lys Ile Tyr Glu Lys Asn Tyr Glu Lys Met 
            580                 585                 590         


Ile Leu Ala Arg Arg Asn Leu Gly Leu Phe Gln His His Asp Ala Ile 
        595                 600                 605             


Thr Gly Thr Ser Lys Ala Asn Val Met Arg Asp Tyr Ala Leu Arg Leu 
    610                 615                 620                 


Phe Glu Ser Ile Gln Asp Ser Val Lys Leu Gln Glu Lys Thr Ile Glu 
625                 630                 635                 640 


Leu Leu Val Gln Lys Lys Gly Thr Glu His Asn Phe Leu Ile Gly Glu 
                645                 650                 655     


Leu Glu Arg Asp Asn Phe Ser Lys Leu Pro Arg Lys Thr Pro Leu Ile 
            660                 665                 670         


Val Thr Glu Ala Arg Ser Thr Asp Phe Val Val Tyr Asn Ala Leu Ala 
        675                 680                 685             


Gln Glu Arg Ile Glu Val Val Leu Ile Arg Thr Leu Thr Pro Arg Val 
    690                 695                 700                 


Lys Ile Leu Asp Pro Lys Gly Asn Pro Met Asn Ile Gln Ile Asn Pro 
705                 710                 715                 720 


Val Trp Asn Ile Thr Glu Thr Ser Ser Tyr Ala Ser Arg Lys Ile Ile 
                725                 730                 735     


Pro Ser Asp Lys Glu Tyr Glu Ile Met Phe Val Ala Lys Leu Ala Pro 
            740                 745                 750         


Leu Ser Leu Thr Thr Phe Thr Ala Thr Tyr Asp Asp Glu Phe Lys Pro 
        755                 760                 765             


Lys Met Ala Thr Leu Tyr Cys Asn Glu Cys Gln Asp Glu Lys Asn Glu 
    770                 775                 780                 


Ile Phe Glu Ile Arg Asn Lys Gln Pro Gly Asp Ile Gln Leu Glu Asn 
785                 790                 795                 800 


Phe Lys Met Arg Leu Leu Phe Asp Glu Gln Ser Gly Phe Leu Lys Ser 
                805                 810                 815     


Val Thr Lys Lys Asn Met Gly Lys Gln Ile Gln Cys Ala Ile Lys Phe 
            820                 825                 830         


Ala Ala Tyr Lys Ser Ala Gln Phe His Ser Gly Ala Tyr Leu Phe Lys 
        835                 840                 845             


Thr Asp Pro Glu Gln Arg Asn Ser Glu Lys Glu Ile Leu Glu Gln Tyr 
    850                 855                 860                 


Asn Asp Met Thr Ile Leu Ile Thr Ser Gly Pro Leu Ala Ser Asp Val 
865                 870                 875                 880 


Thr Ala Ile Tyr Gly Pro Phe Leu Ala His Thr Val Arg Ile Phe Asn 
                885                 890                 895     


Ser Asn Thr Val Leu Asp Asn Gly Ile Phe Ile Glu Asn Asp Ile Asp 
            900                 905                 910         


Phe Glu Met Pro Pro Lys Asn Arg Glu Thr Glu Leu Phe Met Arg Phe 
        915                 920                 925             


Val Thr Asp Ile Glu Asn Gly Ala Ser Glu Asn Pro Glu Phe Phe Ser 
    930                 935                 940                 


Asp Leu Asn Gly Phe Gln Tyr Gln Lys Arg Val Lys Val Pro Ser Ile 
945                 950                 955                 960 


Gly Ile Glu Gly Asn Tyr Phe Pro Ile Thr Ser Gly Ala Phe Ile Gln 
                965                 970                 975     


Asp Asp Lys Met Arg Leu Thr Leu Leu Thr Thr His Ala Gln Gly Ala 
            980                 985                 990         


Ala Ser Leu Glu Pro Gly Gln Leu  Glu Val Met Leu Asp  Arg Arg Thr 
        995                 1000                 1005             


Leu Tyr  Asp Asp Tyr Arg Gly  Met Gly Glu Gly Val  Val Asp Ser 
    1010                 1015                 1020             


Arg Leu  Thr Arg His Arg Phe  Trp Val Val Leu Glu  Asn Ile Glu 
    1025                 1030                 1035             


Ser His  Ser Pro Pro Leu Ala  Glu Asn Pro Pro Gly  Pro Ala Asp 
    1040                 1045                 1050             


Glu Pro  Lys Pro Ala Glu Phe  Gln Leu Pro Ser Ile  Phe Ala Asn 
    1055                 1060                 1065             


Gln Leu  Thr Asn Gly Leu Asn  Tyr Pro Ala Asn Leu  Phe Ile Val 
    1070                 1075                 1080             


Glu Lys  Tyr Asp Glu Ser Asn  Gln Ile Glu Leu Asn  Arg Ala Val 
    1085                 1090                 1095             


Gln Leu  Leu Ala Ala Pro Phe  Pro Cys Asp Leu His  Ile Leu Asn 
    1100                 1105                 1110             


Leu Arg  Thr Leu Thr Glu Gly  Asn Leu Pro Leu Phe  Pro Ser Ser 
    1115                 1120                 1125             


Gly Ala  Leu Leu Val Leu His  Arg Gln Gly Tyr Asp  Cys Arg Ile 
    1130                 1135                 1140             


Gly Gly  Glu Glu Val Val Asn  Tyr Phe Cys Asn Asn  Ser Ser Ser 
    1145                 1150                 1155             


Ser Val  Ser Leu Ser Ser Asn  Ser Asn Asn Tyr Lys  Asn Val Asp 
    1160                 1165                 1170             


Lys Tyr  Asn Ser Arg Leu Gln  Leu Phe Gly Gly Val  Gln Ile Glu 
    1175                 1180                 1185             


Gln Ile  Thr Gly Thr Ser Leu  Thr Gly Leu His Pro  Gly Ala Pro 
    1190                 1195                 1200             


Val Arg  Ser Val Gly Asp Ile  Phe Leu Glu Pro Met  Glu Leu Arg 
    1205                 1210                 1215             


Thr Phe  Asn Leu Thr Phe Val  Lys 
    1220                 1225     


<210>  4
<211>  7138
<212>  DNA
<213>  artificial sequence

<220>
<223>  sequence of cDNA encoding alpha mannidose

<400>  4
cactacaccg cctcgccatt gcattttgga ccgtggaaag ccggatcggg gatctaatct       60

tgatgtagcc gattacctcc acaccgtacc cacaaaaagg atcgcccgag tagaagaaca      120

cttgaacgtg gccagcagca gcagcttaga cgtcgccatc atctattcga agaacaaaaa      180

tcctagaaaa tgtaattttc attccaccgg caagaccaaa gtgaattaaa ctgaactccc      240

ccggatgtga agtcctgttt tagcttgttg tgtgagtgtt tgtgtgtcag aagacagagg      300

aaaaatcata aagtgtcaca ttctaccgtg agtgaaacgt gaaagccgca tcggcaccca      360

taaatgagtg aatatcgcgc gccgaaagtt tagggtggaa aattgcaccg agttggtggg      420

gtgctgcttc ctgtttattg ccccataatc aagtgccgag ggagcagaag cagaaaaaag      480

gtgcctgcag cgccgcagca tcatgaccgt gaaaattttc cgccggggtt cggcccgctg      540

catagggctc ctgtcggctt tcgtaaccat tttgctgtgc ttgtactaca tctcgatggg      600

acagccatca aacacgccaa cgacgaccgc cacttccggt ggctcctcgc tccacaagga      660

tgctgccctg caccagaaac gattaagcaa ccttcatgca gatccgcacc acggcgccgg      720

gagcaatccg aatgcaaacc aatcctggca cagttggctg cggaacaatc tcaattcgat      780

caacaacggt ggcaacggca aggatcgacc gcccggcctg ggaccggaag tgtccgacag      840

tggaggctac ccggatggtg atgggggtgg aggtggtgtc ggggctgctg ctgcagcagt      900

ggccggaagt catccgcctc ggttcagcgc caagtgggac gaatgtgtcg cactggagga      960

aaccccaacc gatatcacca ccggcgatga gtatggaaat ttcgacttcc agcccgaatg     1020

gatgaaaaca aaggaatact gggacaagga cttcgagagc cgttacgaga agctgcagaa     1080

ggatccgaac cgacccccgt tgaagattgt ggtagttccg cactcccata atgaccccgg     1140

gtggttgaag accttcgtca actacttcca gtcggattcg aggcagattc tgaacttggc     1200

cgtcactaag atgcccgagt acaacaacat gtcgtttata tggagtgaga tcagctttct     1260

gcagttatgg tgggatcaag cacatcccac caagcagagg atattgaaaa agttggtgaa     1320

atcaggtcgt ttggagatca ctactggagg ctgggtcatg acggatgaag cgaatgctca     1380

tctttatgcg atggttgatc agcttattga aggtcatcaa tgggtcaaaa ccaatctgaa     1440

cgtaactccg aagagcggat ggagtataga tccttttgga catggtagta ccgtcccata     1500

cttgttagca gcaagtggtt ttgaaggaac catcatccaa cggatacact acgcgtggaa     1560

gcaatggttc gcccgtcatc gatacggaga tttcctgtgg agtccctact ggcgaacacc     1620

ttctagtggt ctggatcgaa agcacactct cctgactcat aacatgccct tcgacatcta     1680

ctcaatcaaa cattcctgcg ggccacatcc attcatctgc cttaatttcg acttccgcaa     1740

gattcctggc gagtatactg aatactcgat caaagctcag ttcatcacac cggaaaacat     1800

cgaatccaaa gctgaccttc tcatggagca atactcgcgt actgcttccc tgttccctca     1860

caatgtggca ctgattcccg ttggagacga tttccgttac aacaaggata aagaaatgga     1920

gcaacagtac accaactaca agaagctgat cgactatatc aacgagaacc gcaacaagta     1980

caaggcggaa atcagctttg gtactccgaa ggactacttc aatgccatca aggaacgcta     2040

cgataaattc ccgactttga aaggagactt tttcgtctac gcagacatct tcaacgaagg     2100

gcgtccagca tactggtctg gatatttcac cacccgaccg tattacaaga ttctcagtcg     2160

agaactcgaa cacaaccttc gtagcttgga aattctgttc accttggctt tcaaccgagc     2220

caggcaagct ggtaattcca atgccttcaa gatctacgaa aagaactacg agaagatgat     2280

ccttgctagg cggaacctag gccttttcca acatcacgat gccatcaccg gaacgtccaa     2340

agccaatgtg atgcgagact acgctctgag gctgtttgaa agcatccaag actccgtcaa     2400

gcttcaagag aaaaccatag aactgctcgt ccagaagaaa ggcaccgagc acaactttct     2460

gatcggagag ctggagcggg ataacttcag caaactccct cggaagactc ctctgatcgt     2520

cacggaagca cggagtacgg acttcgtggt ctacaacgcc ctcgcgcaag aacggataga     2580

agtcgttctg atcagaacac tgaccccgcg cgttaaaatt ctcgatccga aaggtaaccc     2640

aatgaacata caaatcaacc cggtgtggaa catcacggaa acttcatctt acgcatcccg     2700

gaagatcatt ccctcggaca aggagtacga aatcatgttt gtggcgaagc tggcacctct     2760

ttcgctaacg acctttacgg ccacctatga cgacgagttc aaaccgaaga tggcaacgct     2820

gtactgcaac gagtgccaag atgagaaaaa tgagatattc gagatccgga acaaacaacc     2880

gggcgacatt cagctggaaa acttcaaaat gaggctgttg tttgatgagc agagcggttt     2940

cttgaagtcc gtgactaaga aaaacatggg taagcaaatt cagtgcgcga tcaagtttgc     3000

cgcgtacaag agtgcgcagt tccactctgg tgcgtatctg ttcaagacgg atccggagca     3060

aaggaattca gagaaagaga tactagagca gtataatgac atgacaattc tgataacttc     3120

cggcccactg gcaagtgacg ttacagcaat ctacggacca ttcctggctc acaccgtgcg     3180

gatattcaac tccaacacgg tgctggataa cggaatcttc atcgagaatg acatcgactt     3240

tgagatgcct ccaaagaaca gggaaacaga actgtttatg cgttttgtga cagacattga     3300

gaatggggct agcgaaaacc ctgaattctt ctcagatctt aatggattcc agtatcagaa     3360

gcgagtgaag gtcccatcga tcggtatcga gggcaactac ttccctatca ccagcggggc     3420

attcattcaa gatgataaga tgaggctaac tttgctcacg acccacgctc aaggcgctgc     3480

cagcttggaa cccggacagc tggaagtaat gctcgatagg cgaactctgt acgacgacta     3540

tcgtggtatg ggagaaggcg ttgtggacag tcgcctgacc cgacatcgat tctgggttgt     3600

tctagagaat attgaatccc attcgccacc gttagctgag aaccctccgg ggccagctga     3660

cgaaccaaaa cccgccgaat ttcaactgcc tagtatattt gccaatcagc tcaccaacgg     3720

gctcaactat ccggccaatc tgttcatcgt ggaaaagtac gacgaaagta accagataga     3780

gctgaaccgg gcggtccaac tgctggccgc tccgttcccc tgtgatctcc acattctgaa     3840

tctccgaacc ctaaccgagg gtaacctgcc cctgtttccg tcgagcggag ctctgctggt     3900

tctacaccgg caaggctacg actgccggat aggtggcgaa gaagtagtaa attatttttg     3960

taacaatagt agtagtagcg taagtcttag tagtaatagt aacaattaca aaaatgtaga     4020

taagtacaat agccggctgc agctctttgg tggggtgcag atcgaacaaa ttaccggcac     4080

gtcgttaacg ggtttgcacc cgggggcacc ggtgcgttcc gtgggggaca ttttccttga     4140

accgatggaa ctgcggacgt tcaacctgac gttcgtcaag tgagaagggg agagcggtgg     4200

cggtggcgaa gagacatcaa gcgaaaggct tccactgggt tcctggtttt ggattggttt     4260

tagaaagttg ttacaaaggt ggtccttgga tagttggctg ggaatcagtt cgggctaaag     4320

attggatgtc ggttttctgt ggtcacttta tggtgcttga ttttaaaata cgattgtaag     4380

attatctttc tttcatgccg ataccagatc cgagtagctg cattctttta acgtgaaggg     4440

tcggcttgac ataatttatc caggcatttg cccagaagat tattttttat ggtgctatga     4500

cctgcgccac aatgttacga caacaaactc gattgcctct agtttcttga tcgtcccaaa     4560

cttccaaggt cctgctctac ttggtcatgc cacctaagtc ggagcgccct tccccggccg     4620

gattcgaggt gaactccatt tttggaggat ttatcacaat tacccagccc atcgtactct     4680

ttcagcattg aagactttct agatatatca agttcaccgt agagttgcgc aagctattgg     4740

ttcatacgtt tgctggcatg aatttcactc aaaaggcttc ggtgtgatgc aaacgcaata     4800

aatttttact cagacgttgt tgcaagggtt tgaacggctt gctcattggt tgattcaaac     4860

acagagtgta ataagaaaaa ctcagcaatc acagaaaaag aaaaccgtct tcgtgagtct     4920

cgtctcagtt cttaagcgtt tcctacgcat cgagataggc gattattatt cttgtcagta     4980

gcaaaccagc ccttaagcca gatttgttgc tgaaaaggaa ccgctaaaga cgttaatcgc     5040

cgacttcttg ccgaaatttc ctatagtgag ttccgtttga actgacattt cttttcaact     5100

gcgtactgcg atcagaaaaa gggctttctt gatcgatttg ttacaggcat ttcccataga     5160

tatttaagca aatcaggctt tagcctgttt tactgctatc tgtaacgttt ttccgatggt     5220

tcatttgatg tggaaattag tttaacgggt tcaatcgccc tcgtacctat cccttgggtt     5280

caatatatgc aaagaagtat tagtgacatg acatgataga cagtcataat caacgaggga     5340

cgatgtatac atcctatagg aatacgaatt gcagagattg tgacgggaat aagtgcggtg     5400

atccttcatt aaatccgaaa tgcgaaaact gcagatatag tgcgcttatc ggacttgtag     5460

ttcagaacca ttgcatttga attttttgct cttattcatt ttactgttac tgtgcataaa     5520

ctaaagatgc tacaaataac agatatctaa gtccaaattg aaaactggca agaatgttaa     5580

ccacaaacga tgatttaacg gcctttcaaa ctggcaacac gtgtagcgtc gctgatatca     5640

tggtgaaaat gaaacatttc aggatgttct taatcactac caattaacac aacatgctga     5700

tccacgttga tatgtgggtc aagtgatatc accatagttg ggtttgaatg cttatacaac     5760

ttttgagaag gtttttgttc caacatcgat aacttttcct gtgcttgaac ttagatacta     5820

agacagcaaa tgtcaaaaat atgagtcact tgtggaaatg tcttctaagt catcgccatt     5880

tgtctctcat tgcttctaca gaaattgaat tcgatcatca agaccaagct atcaaaacca     5940

gatacggaat caaacataag aaaatacaaa cgacatcact ctcttccaag tctatccgat     6000

atgtgaatct cacaaatatt gatctgaact agggcaacaa tttttcgaat atggttttaa     6060

gttattttat tgaaaacaaa aacagcagct gaatcatttc acacgacata gacgaatcta     6120

agcagaaccc ctcaatgtaa tcattccact ttttaagaga agaaaaaaca agaaatctgg     6180

tccagtatat attgttagat ttattattac tgaacaatgc aaaaaatccc cacaatttaa     6240

ttttatgttc gaaacaaaaa gtgcatgtac cattcaagtt ggaaagaaac ctctttgctc     6300

tgtattgtac ataccaaaat ctagcccgta gaatctcctt atctacatac ttttgtgatt     6360

atagtgttag tgatacgttt cttccctgat tcttcgattt ctgttgaaaa cttccattca     6420

tttccatcct gggtccaatt taaatacctc tatccttcac aaacgatttg ttctttcaat     6480

cacagctatg atatttaaag ttttaaccac cgtccagcag gattagttgt tgtcacataa     6540

aattccctac ttttattagt tactatttat taattaaatc taggataccc ctaaaatagt     6600

gagcgtgcgg acgagcagct aatcccaaat gagcccctga tataaacttg tttgatatta     6660

tcctacataa taacaactac gatcaaaagc gattttacaa agaaaaaaaa agcaaagcac     6720

ctacaaggta atgcaaaaga gcaaaacaaa aaaaactagc aaaagatagt aagtaagcaa     6780

atcatcgcgt atgtttagaa aaaggattag ttgttttata aaaggaaatg aacctactgc     6840

agctagaaat taaattttaa aggaaataac ggatcaaccg agcaggaatg aacaaccata     6900

ttcttaaact agaagagaaa gaatttaact attttattgt ttattgtccc gtcgttgaat     6960

ctccgtttat tttacattga tgtctaaagc gtctgtcaga aaatgtgtga ccagttgtag     7020

taaaatttgt ttttaacagt aaattaacca tttgtgcagc tcggaagttt acagttgatt     7080

tcattgcaaa aagtaatcat tacatttttt gttgcaaaat atgtattgat agaacaaa       7138


<210>  5
<211>  649
<212>  RNA
<213>  artificial sequence

<220>
<223>  RNAi strand

<400>  5
gggauaacuu cagcaaacuc ccucggaaga cuccucugau cgucacggaa gcacggagua       60

cggacuucgu ggucuacaac gcccucgcgc aagaacggau agaagucguu cugaucagaa      120

cacugacccc gcgcguuaaa auucucgauc cgaaagguaa cccaaugaac auacaaauca      180

acccggugug gaacaucacg gaaacuucau cuuacgcauc ccggaagauc auucccucgg      240

acaaggagua cgaaaucaug uuuguggcga agcuggcacc ucuuucgcua acgaccuuua      300

cggccaccua ugacgacgag uucaaaccga agauggcaac gcuguacugc aacgagugcc      360

aagaugagaa aaaugagaua uucgagaucc ggaacaaaca accgggcgac auucagcugg      420

aaaacuucaa aaugaggcug uuguuugaug agcagagcgg uuucuugaag uccgugacua      480

agaaaaacau ggguaagcaa auucagugcg cgaucaaguu ugccgcguac aagagugcgc      540

aguuccacuc uggugcguau cuguucaaga cggauccgga gcaaaggaau ucagagaaag      600

agauacuaga gcaguauaau gacaugacaa uucugauaac uuccggccc                  649


<210>  6
<211>  680
<212>  RNA
<213>  artificial sequence

<220>
<223>  RNAi strand

<400>  6
gggacauccg caucgguaaa auccaggccu auuacgacac acccgacccg aaaaucuacu       60

acuacaugau gcucggcaac gaggauggag cguucuacgu ggacaaaacc accggcgaua      120

ucuacaccaa caaaacgcug gaccgcgagg aagcggaugu cuacgcucuc uauaucaaag      180

ccagcaagaa acaagaccug cugaucacug agcgcgaucg gaugaugaug ucgaccaaaa      240

agcuggaacg cgauagcacg guugcgaagg ucuggaucac aguccucgau gucaacgaca      300

aucccccggu cuuuaaacag gacguuuacu acgcuggcgu aagcuccaag gcugccauca      360

acgaauuggu gacaauuguc aaugcgaccg aucgagaucu gggcgugaac ucuaccaugg      420

aacuguucau cagcgggucu uaucuuuaca aauacggagc uacgaagaca acugguagca      480

uaguuccaag uccguucacu auuuccaagg acggucguau aacuaccgca aacuacaugg      540

ccgaauauaa ccaggaccgu uucauucugg acauuguagc aaaagaggug gaaucuccug      600

agcgaguugc caccaccaaa gucuacgucu ggaucuucaa uccagaacaa cuagugcgug      660

ugauccuguc gaggccaccc                                                  680


<210>  7
<211>  38
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  7
taatacgact cactataggg ataacttcag caaactcc                               38


<210>  8
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  8
taatacgact cactataggg ccggaagtta tcagaat                                37


<210>  9
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  9
taatacgact cactataggg acatccgcat cggta                                  35


<210>  10
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  10
taatacgact cactataggg tggcctcgac aggat                                  35


<210>  11
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  11
aaggactaga ggttagagga gaccc                                             25


<210>  12
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  12
cgttctgtgc ctggaatgat g                                                 21


<210>  13
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  13
tccgtggtat ctccatcaag ct                                                22


<210>  14
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  14
caggaggagg aacgtgagcg cag                                               23


<210>  15
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  15
caaattgctc ttgtcctgtg g                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  GGGTGTTAAGCAGAGTTACGG

<400>  16
gggtgttaag cagagttacg g                                                 21


<210>  17
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  probe

<400>  17
tgaaatggaa aaattggcga ggtgtagg                                          28


<210>  18
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  probe

<400>  18
aacagcatat tgacgctggg agagaccaga                                        30


<210>  19
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  probe

<400>  19
caggaggagg aacgtgagcg cag                                               23


