                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  SEQUENTIAL IMMUNIZATION STRATEGIES TO GUIDE THE

<130>  F053-0088PCT/18-042-WO-PCT

<140>  PCT/US2019/048825
<141>  2019-08-29

<150>  US 62/724,555
<151>  2018-08-29

<160>  275   

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ile Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hxb2 Core protein loop

<400>  3

Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys 
1               5                   10      


<210>  4
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  45_01dH1 Core protein loop

<400>  5

Ile Arg Ser Glu Asn Leu Thr Asp Asn Ala Lys 
1               5                   10      


<210>  6
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Asn Ser Asp Tyr Thr Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Thr Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Ser Gly Gly Thr Asn Tyr Pro Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Ile Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  93TH057 Core protein loop

<400>  10

Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys 
1               5                   10      


<210>  11
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe Ile Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  12
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Gly Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asp Thr Asp Tyr Ile Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Thr Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Gln 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro His Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Core protein loop

<400>  21

Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys 
1               5                   10      


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  22
gatggtggga agatggatac agtt                                              24


<210>  23
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  23
gccaccgtac gtttgatttc cagcttggtg                                        30


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  24
gccaccgtac gttttatttc cagcttggtc                                        30


<210>  25
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asp Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


His Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Ile Ile Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  29
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Thr Arg Gly Gly Ile Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Ile Ile Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ala Val Lys Val Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Phe Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  32
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Ile Ile Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Ser Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  33
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Thr Arg Gly Gly Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  34
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Thr Arg Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  35
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Thr Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  36
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Ala Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Phe Arg Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Phe 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  37
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Ala Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Phe Arg Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  38
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  38
gccaccgtac gttttatttc caactttgtc                                        30


<210>  39
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c core-gp120 construct

<400>  39

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ser Val Trp Lys Glu Ala Lys Thr 
            20                  25                  30          


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Cys His 
        35                  40                  45              


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
    50                  55                  60                  


Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
65                  70                  75                  80  


Asp Met Val Asp Gln Met Gln Glu Asp Val Ile Ser Ile Trp Asp Gln 
                85                  90                  95      


Cys Leu Lys Pro Cys Val Lys Leu Thr Asn Thr Ser Thr Leu Thr Gln 
            100                 105                 110         


Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
        115                 120                 125             


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
    130                 135                 140                 


Lys Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
145                 150                 155                 160 


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                165                 170                 175     


Glu Glu Ile Val Ile Arg Ser Lys Asn Leu Ser Asp Asn Ala Lys Ile 
            180                 185                 190         


Ile Ile Val Gln Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro 
        195                 200                 205             


Asn Asn Gly Gly Ser Gly Ser Gly Gly Asp Ile Arg Gln Ala Tyr Cys 
    210                 215                 220                 


Asn Ile Ser Gly Arg Asn Trp Ser Glu Ala Val Asn Gln Val Lys Lys 
225                 230                 235                 240 


Lys Leu Lys Glu His Phe Pro His Lys Asn Ile Ser Phe Gln Ser Ser 
                245                 250                 255     


Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly 
            260                 265                 270         


Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Asp Thr Ile Ser 
        275                 280                 285             


Asn Ala Thr Ile Met Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met 
    290                 295                 300                 


Trp Gln Glu Val Gly Lys Ala Ile Tyr Ala Pro Pro Ile Lys Gly Asn 
305                 310                 315                 320 


Ile Thr Cys Lys Ser Asp Ile Thr Gly Leu Leu Leu Leu Arg Asp Gly 
                325                 330                 335     


Gly Asn Thr Thr Asn Asn Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp 
            340                 345                 350         


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu 
        355                 360                 365             


Ile Lys Pro Leu 
    370         


<210>  40
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eOD-GT8-hisavi construct

<400>  40

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ser Asp Thr Ile Thr Leu Pro Cys 
            20                  25                  30          


Arg Pro Ala Pro Pro Pro His Cys Ser Ser Asn Ile Thr Gly Leu Ile 
        35                  40                  45              


Leu Thr Arg Gln Gly Gly Tyr Ser Asn Asp Asn Thr Val Ile Phe Arg 
    50                  55                  60                  


Pro Ser Gly Gly Asp Trp Arg Asp Ile Ala Arg Cys Gln Ile Ala Gly 
65                  70                  75                  80  


Thr Val Val Ser Thr Gln Leu Phe Leu Asn Gly Ser Leu Ala Glu Glu 
                85                  90                  95      


Glu Val Val Ile Arg Ser Glu Asp Trp Arg Asp Asn Ala Lys Ser Ile 
            100                 105                 110         


Cys Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly Ala Gly 
        115                 120                 125             


His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile 
    130                 135                 140                 


Ala Ser Lys Leu Arg Glu Gln Tyr Gly Asn Lys Thr Ile Ile Phe Lys 
145                 150                 155                 160 


Pro Ser Ser Gly Gly Asp Pro Glu Phe Val Asn His Ser Phe Asn Cys 
                165                 170                 175     


Gly Gly Glu Phe Phe Tyr Cys Asp Ser Thr Gln Leu Phe Asn Ser Thr 
            180                 185                 190         


Trp Phe Asn Ser Thr 
        195         


<210>  41
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c:BG505_WT-Sosip construct

<400>  41

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp 
                85                  90                  95      


Gln Met Gln Glu Asp Val Ile Ser Ile Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Val 
        115                 120                 125             


Asn Val Thr Ser Asn Ser Thr Asn Val Asn Ser Ser Ser Thr Asp Asn 
    130                 135                 140                 


Thr Thr Leu Gly Glu Ile Lys Asn Cys Ser Phe Asp Ile Thr Thr Glu 
145                 150                 155                 160 


Ile Arg Asp Lys Thr Arg Lys Glu Tyr Ala Leu Phe Tyr Arg Leu Asp 
                165                 170                 175     


Ile Val Pro Leu Asp Asn Ser Ser Asn Pro Asn Ser Ser Asn Thr Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Thr Cys Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys 
225                 230                 235                 240 


Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val 
            260                 265                 270         


Ile Arg Ser Lys Asn Leu Ser Asp Asn Ala Lys Ile Ile Ile Val Gln 
        275                 280                 285             


Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Arg Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Asp 
305                 310                 315                 320 


Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn 
                325                 330                 335     


Trp Ser Glu Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe 
            340                 345                 350         


Pro His Lys Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu 
        355                 360                 365             


Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Ser Gly Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu 
385                 390                 395                 400 


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys 
                405                 410                 415     


Cys Ile Tyr Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp 
            420                 425                 430         


Ile Thr Gly Leu Leu Leu Leu Arg Asp Gly Gly Asn Thr Thr Asn Asn 
        435                 440                 445             


Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
465                 470                 475                 480 


Ala Pro Thr Arg Cys Lys Arg Arg Val Val Gly Arg Arg Arg Arg Arg 
                485                 490                 495     


Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala 
            500                 505                 510         


Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg 
        515                 520                 525             


Asn Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala 
    530                 535                 540                 


Pro Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys 
545                 550                 555                 560 


Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln 
                565                 570                 575     


Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr 
            580                 585                 590         


Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Asn Leu Ser Glu Ile 
        595                 600                 605             


Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr 
    610                 615                 620                 


Thr Gln Ile Ile Tyr Gly Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu 
625                 630                 635                 640 


Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp 
                645                 650 


<210>  42
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c:BG505_TM-Sosip construct

<400>  42

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val 
            20                  25                  30          


Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys 
        35                  40                  45              


Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val His Asn Val Trp Ala 
    50                  55                  60                  


Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu 
65                  70                  75                  80  


Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp 
                85                  90                  95      


Gln Met Gln Glu Asp Val Ile Ser Ile Trp Asp Gln Ser Leu Lys Pro 
            100                 105                 110         


Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Val 
        115                 120                 125             


Asn Val Thr Ser Asn Ser Thr Asn Val Asn Ser Ser Ser Thr Asp Asn 
    130                 135                 140                 


Thr Thr Leu Gly Glu Ile Lys Asn Cys Ser Phe Asp Ile Thr Thr Glu 
145                 150                 155                 160 


Ile Arg Asp Lys Thr Arg Lys Glu Tyr Ala Leu Phe Tyr Arg Leu Asp 
                165                 170                 175     


Ile Val Pro Leu Asp Asn Ser Ser Asn Pro Asn Ser Ser Asn Thr Tyr 
            180                 185                 190         


Arg Leu Ile Asn Cys Asn Thr Ser Thr Cys Thr Gln Ala Cys Pro Lys 
        195                 200                 205             


Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr 
    210                 215                 220                 


Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys 
225                 230                 235                 240 


Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val 
                245                 250                 255     


Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val 
            260                 265                 270         


Ile Arg Ser Lys Asn Leu Ala Asp Asn Ala Lys Ile Ile Ile Val Gln 
        275                 280                 285             


Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr 
    290                 295                 300                 


Arg Arg Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Asp 
305                 310                 315                 320 


Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn 
                325                 330                 335     


Trp Ser Glu Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe 
            340                 345                 350         


Pro His Lys Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu 
        355                 360                 365             


Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
    370                 375                 380                 


Thr Ser Gly Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu 
385                 390                 395                 400 


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys 
                405                 410                 415     


Cys Ile Tyr Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp 
            420                 425                 430         


Ile Thr Gly Leu Leu Leu Leu Arg Asp Gly Gly Asn Thr Ala Asn Asn 
        435                 440                 445             


Ala Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
465                 470                 475                 480 


Ala Pro Thr Arg Cys Lys Arg Arg Val Val Gly Arg Arg Arg Arg Arg 
                485                 490                 495     


Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala 
            500                 505                 510         


Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg 
        515                 520                 525             


Asn Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala 
    530                 535                 540                 


Pro Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys 
545                 550                 555                 560 


Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln 
                565                 570                 575     


Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr 
            580                 585                 590         


Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Asn Leu Ser Glu Ile 
        595                 600                 605             


Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr 
    610                 615                 620                 


Thr Gln Ile Ile Tyr Gly Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu 
625                 630                 635                 640 


Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp 
                645                 650 


<210>  43
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c:BG505_SM-Sosip construct

<400>  43

Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly Met Leu 
1               5                   10                  15      


Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val Tyr Tyr 
            20                  25                  30          


Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser 
        35                  40                  45              


Asp Ala Lys Ala Tyr Glu Lys Glu Val His Asn Val Trp Ala Thr His 
    50                  55                  60                  


Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn 
65                  70                  75                  80  


Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met 
                85                  90                  95      


Gln Glu Asp Val Ile Ser Ile Trp Asp Gln Ser Leu Lys Pro Cys Val 
            100                 105                 110         


Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Val Asn Val 
        115                 120                 125             


Thr Ser Asn Ser Thr Asn Val Asn Ser Ser Ser Thr Asp Asn Thr Thr 
    130                 135                 140                 


Leu Gly Glu Ile Lys Asn Cys Ser Phe Asp Ile Thr Thr Glu Ile Arg 
145                 150                 155                 160 


Asp Lys Thr Arg Lys Glu Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val 
                165                 170                 175     


Pro Leu Asp Asn Ser Ser Asn Pro Asn Ser Ser Asn Thr Tyr Arg Leu 
            180                 185                 190         


Ile Asn Cys Asn Thr Ser Thr Cys Thr Gln Ala Cys Pro Lys Val Thr 
        195                 200                 205             


Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile 
    210                 215                 220                 


Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Asn Asn 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg 
            260                 265                 270         


Ser Lys Asn Leu Ala Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn 
        275                 280                 285             


Lys Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Arg 
    290                 295                 300                 


Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Asp Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn Trp Ser 
                325                 330                 335     


Glu Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe Pro His 
            340                 345                 350         


Lys Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
    370                 375                 380                 


Gly Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu Pro Cys 
385                 390                 395                 400 


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Cys Ile 
                405                 410                 415     


Tyr Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp Ile Thr 
            420                 425                 430         


Gly Leu Leu Leu Leu Arg Asp Gly Gly Asn Thr Thr Asn Asn Thr Glu 
        435                 440                 445             


Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
    450                 455                 460                 


Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro 
465                 470                 475                 480 


Thr Arg Cys Lys Arg Arg Val Val Gly Arg Arg Arg Arg Arg Arg Ala 
                485                 490                 495     


Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
            500                 505                 510         


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Asn Leu 
        515                 520                 525             


Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu 
    530                 535                 540                 


Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu 
545                 550                 555                 560 


Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu 
                565                 570                 575     


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr Asn Val 
            580                 585                 590         


Pro Trp Asn Ser Ser Trp Ser Asn Arg Asn Leu Ser Glu Ile Trp Asp 
        595                 600                 605             


Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Gln 
    610                 615                 620                 


Ile Ile Tyr Gly Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
625                 630                 635                 640 


Glu Gln Asp Leu Leu Ala Leu Asp 
                645             


<210>  44
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  45_01dG5core-gp120 construct

<400>  44

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ser Val Trp Lys Glu Ala Thr Ala 
            20                  25                  30          


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Cys His 
        35                  40                  45              


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
    50                  55                  60                  


Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
65                  70                  75                  80  


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
                85                  90                  95      


Cys Leu Lys Pro Cys Val Lys Leu Thr Asn Thr Ser Val Ile Thr Gln 
            100                 105                 110         


Ala Cys Pro Lys Ile Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
        115                 120                 125             


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly 
    130                 135                 140                 


Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
145                 150                 155                 160 


Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                165                 170                 175     


Glu Glu Ile Val Ile Arg Ser Glu Asn Ile Lys Asp Asn Ala Lys Ile 
            180                 185                 190         


Ile Ile Val Gln Leu Asn Glu Thr Val Glu Ile Asn Cys Thr Arg Pro 
        195                 200                 205             


Asn Asn Gly Gly Ser Gly Ser Gly Gly Asp Ile Arg Gln Ala His Cys 
    210                 215                 220                 


Asn Ile Ser Lys Ala Lys Trp Glu Asn Thr Leu Lys Gln Ile Ala Arg 
225                 230                 235                 240 


Lys Leu Arg Glu His Phe Lys Asn Glu Thr Ile Ala Phe Asn Gln Ser 
                245                 250                 255     


Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 
            260                 265                 270         


Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Thr 
        275                 280                 285             


Trp Asn Asp Thr Glu Val Val Asn Asn Thr Glu Lys Asn Ile Asn Ile 
    290                 295                 300                 


Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val 
305                 310                 315                 320 


Gly Lys Ala Met Tyr Ala Pro Pro Ile Lys Gly Gln Ile Arg Cys Ser 
                325                 330                 335     


Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Ser Ser Thr 
            340                 345                 350         


Asn Gly Thr Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp 
        355                 360                 365             


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro 
    370                 375                 380                 


Leu 
385 


<210>  45
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  45_01dH1core-gp120 construct

<400>  45

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ser Val Trp Lys Glu Ala Ser Thr 
            20                  25                  30          


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Cys His 
        35                  40                  45              


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
    50                  55                  60                  


Glu Val Val Leu Glu Asn Val Thr Glu Lys Phe Asn Met Trp Lys Asn 
65                  70                  75                  80  


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
                85                  90                  95      


Cys Leu Lys Pro Cys Val Lys Leu Thr Asn Thr Ser Val Ile Thr Gln 
            100                 105                 110         


Ala Cys Pro Lys Ile Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
        115                 120                 125             


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly 
    130                 135                 140                 


Thr Gly Lys Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
145                 150                 155                 160 


Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                165                 170                 175     


Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Ala Lys Thr 
            180                 185                 190         


Leu Ile Val Gln Leu Asn Glu Thr Val Ala Ile Asn Cys Thr Arg Pro 
        195                 200                 205             


Asn Asn Gly Gly Ser Gly Ser Gly Gly Asn Ile Arg Gln Ala His Cys 
    210                 215                 220                 


Asn Ile Ser Glu Thr Asp Trp Asn Asn Thr Leu Lys Gln Val Ala Arg 
225                 230                 235                 240 


Lys Leu Arg Glu Leu Phe Asn Lys Thr Ile Val Phe Asn Gln Ser Ser 
                245                 250                 255     


Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu 
            260                 265                 270         


Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp His Gly 
        275                 280                 285             


Asn Glu Thr Glu Glu Ser Ser Ile Thr Lys Asp Asn Lys Thr Ile Thr 
    290                 295                 300                 


Leu Pro Cys Arg Ile Lys Gln Ile Val Asn Arg Trp Gln Glu Val Gly 
305                 310                 315                 320 


Lys Ala Met Tyr Ala Pro Pro Ile Glu Gly Leu Ile Arg Cys Ser Ser 
                325                 330                 335     


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ile Thr Asn 
            340                 345                 350         


Glu Thr Thr Thr Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Arg Asp 
        355                 360                 365             


Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro 
    370                 375                 380                 


Leu 
385 


<210>  46
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c:BG505_DM-Sosip construct

<400>  46

Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly Met Leu 
1               5                   10                  15      


Val Ala Ser Val Leu Ala Ala Glu Asn Leu Trp Val Thr Val Tyr Tyr 
            20                  25                  30          


Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser 
        35                  40                  45              


Asp Ala Lys Ala Tyr Glu Lys Glu Val His Asn Val Trp Ala Thr His 
    50                  55                  60                  


Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn 
65                  70                  75                  80  


Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met 
                85                  90                  95      


Gln Glu Asp Val Ile Ser Ile Trp Asp Gln Ser Leu Lys Pro Cys Val 
            100                 105                 110         


Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Val Asn Val 
        115                 120                 125             


Thr Ser Asn Ser Thr Asn Val Asn Ser Ser Ser Thr Asp Asn Thr Thr 
    130                 135                 140                 


Leu Gly Glu Ile Lys Asn Cys Ser Phe Asp Ile Thr Thr Glu Ile Arg 
145                 150                 155                 160 


Asp Lys Thr Arg Lys Glu Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val 
                165                 170                 175     


Pro Leu Asp Asn Ser Ser Asn Pro Asn Ser Ser Asn Thr Tyr Arg Leu 
            180                 185                 190         


Ile Asn Cys Asn Thr Ser Thr Cys Thr Gln Ala Cys Pro Lys Val Thr 
        195                 200                 205             


Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile 
    210                 215                 220                 


Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Asn Asn 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg 
            260                 265                 270         


Ser Lys Asn Leu Ser Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn 
        275                 280                 285             


Lys Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Arg 
    290                 295                 300                 


Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Asp Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn Trp Ser 
                325                 330                 335     


Glu Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe Pro His 
            340                 345                 350         


Lys Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
    370                 375                 380                 


Gly Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu Pro Cys 
385                 390                 395                 400 


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Cys Ile 
                405                 410                 415     


Tyr Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp Ile Thr 
            420                 425                 430         


Gly Leu Leu Leu Leu Arg Asp Gly Gly Asn Thr Ala Asn Asn Ala Glu 
        435                 440                 445             


Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
    450                 455                 460                 


Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro 
465                 470                 475                 480 


Thr Arg Cys Lys Arg Arg Val Val Gly Arg Arg Arg Arg Arg Arg Ala 
                485                 490                 495     


Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
            500                 505                 510         


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Asn Leu 
        515                 520                 525             


Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu 
    530                 535                 540                 


Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu 
545                 550                 555                 560 


Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu 
                565                 570                 575     


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Cys Thr Asn Val 
            580                 585                 590         


Pro Trp Asn Ser Ser Trp Ser Asn Arg Asn Leu Ser Glu Ile Trp Asp 
        595                 600                 605             


Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Gln 
    610                 615                 620                 


Ile Ile Tyr Gly Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
625                 630                 635                 640 


Glu Gln Asp Leu Leu Ala Leu Asp 
                645             


<210>  47
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hxb2core-gp120 construct

<400>  47

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ser Val Trp Lys Glu Ala Thr Thr 
            20                  25                  30          


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Cys His 
        35                  40                  45              


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
    50                  55                  60                  


Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
65                  70                  75                  80  


Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
                85                  90                  95      


Cys Leu Lys Pro Cys Val Lys Leu Thr Asn Thr Ser Val Ile Thr Gln 
            100                 105                 110         


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
        115                 120                 125             


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
    130                 135                 140                 


Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
145                 150                 155                 160 


Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                165                 170                 175     


Glu Glu Val Val Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr 
            180                 185                 190         


Ile Ile Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro 
        195                 200                 205             


Asn Asn Gly Gly Ser Gly Ser Gly Gly Asn Met Arg Gln Ala His Cys 
    210                 215                 220                 


Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser 
225                 230                 235                 240 


Lys Leu Arg Glu Gln Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln 
                245                 250                 255     


Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly 
            260                 265                 270         


Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp 
        275                 280                 285             


Phe Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser 
    290                 295                 300                 


Asp Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
305                 310                 315                 320 


Gln Lys Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile 
                325                 330                 335     


Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
            340                 345                 350         


Asn Ser Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met 
        355                 360                 365             


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
    370                 375                 380                 


Glu Pro Leu 
385         


<210>  48
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QH0692core-gp120 construct

<400>  48

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ser Val Trp Lys Glu Ala Thr Thr 
            20                  25                  30          


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Cys His 
        35                  40                  45              


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
    50                  55                  60                  


Glu Val Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
65                  70                  75                  80  


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Glu 
                85                  90                  95      


Cys Leu Lys Pro Cys Val Lys Leu Thr Asn Thr Ser Val Ile Thr Gln 
            100                 105                 110         


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
        115                 120                 125             


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
    130                 135                 140                 


Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
145                 150                 155                 160 


Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                165                 170                 175     


Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr 
            180                 185                 190         


Ile Ile Val His Leu Lys Lys Ser Val Glu Ile Asn Cys Thr Arg Pro 
        195                 200                 205             


Gly Asn Gly Gly Ser Gly Ser Gly Gly Asp Ile Arg Gln Ala His Cys 
    210                 215                 220                 


Asn Leu Ser Ser Val Gln Trp Asn Asp Thr Leu Lys Gln Ile Val Ile 
225                 230                 235                 240 


Lys Leu Gly Glu Gln Phe Gly Thr Asn Lys Thr Ile Ala Phe Asn Gln 
                245                 250                 255     


Ser Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly 
            260                 265                 270         


Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp 
        275                 280                 285             


Glu Phe His Gly Asn Trp Thr Arg Ser Asn Phe Thr Glu Ser Asn Ser 
    290                 295                 300                 


Thr Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Val Asn Met Trp 
305                 310                 315                 320 


Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile 
                325                 330                 335     


Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
            340                 345                 350         


Val Asn Gly Thr Arg Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
        355                 360                 365             


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
    370                 375                 380                 


Pro Leu 
385     


<210>  49
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c_WTcore-C4b construct

<400>  49

Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Glu Lys Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp 
    50                  55                  60                  


Val Ile Ser Ile Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn 
145                 150                 155                 160 


Leu Ser Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val 
                165                 170                 175     


Glu Ile Val Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu 
        195                 200                 205             


Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe Pro His Lys 
    210                 215                 220                 


Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr 
225                 230                 235                 240 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
                245                 250                 255     


Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu Pro Cys Arg 
            260                 265                 270         


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Ile Tyr 
        275                 280                 285             


Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly 
    290                 295                 300                 


Leu Leu Leu Leu Arg Asp Gly Gly Asn Thr Thr Asn Asn Thr Glu Ile 
305                 310                 315                 320 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                325                 330                 335     


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ser Ser Lys Lys 
            340                 345                 350         


Gln Gly Asp Ala Asp Val Cys Gly Glu Val Ala Tyr Ile Gln Ser Val 
        355                 360                 365             


Val Ser Asp Cys His Val Pro Thr Ala Glu Leu Arg Thr Leu Leu Glu 
    370                 375                 380                 


Ile Arg Lys Leu Phe Leu Glu Ile Gln Lys Leu Lys Val Glu Leu Gln 
385                 390                 395                 400 


Gly Leu Ser Lys Glu 
                405 


<210>  50
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified C terminal of C4b from Gallus gallus

<400>  50

Ser Lys Lys Gln Gly Asp Ala Asp Val Cys Gly Glu Val Ala Tyr Ile 
1               5                   10                  15      


Gln Ser Val Val Ser Asp Cys His Val Pro Thr Ala Glu Leu Arg Thr 
            20                  25                  30          


Leu Leu Glu Ile Arg Lys Leu Phe Leu Glu Ile Gln Lys Leu Lys Val 
        35                  40                  45              


Glu Leu Gln Gly Leu Ser Lys Glu 
    50                  55      


<210>  51
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C terminal of ferritin

<400>  51

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                165                 170                 175 


<210>  52
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of anti-B6 monoclonal antibody

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Thr Arg Gly Gly Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  53
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain of anti-B6 monoclonal antibody

<400>  53

Asp Ile Val Met Ser Gln Ser Pro Ser Pro Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Asn Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Glu Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  54
<211>  847
<212>  PRT
<213>  Human immunodeficiency virus 1

<400>  54

Met Arg Val Lys Gly Ile Arg Lys Ser Tyr Gln Tyr Leu Trp Lys Gly 
1               5                   10                  15      


Gly Thr Leu Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Val Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu His Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met Gln Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Lys Asp Val Asn Ala Thr Asn Thr Thr Asn Asp Ser Glu Gly 
    130                 135                 140                 


Thr Met Glu Arg Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr 
145                 150                 155                 160 


Ser Ile Arg Asp Glu Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu 
                165                 170                 175     


Asp Val Val Pro Ile Asp Asn Asn Asn Thr Ser Tyr Arg Leu Ile Ser 
            180                 185                 190         


Cys Asp Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu 
        195                 200                 205             


Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys 
    210                 215                 220                 


Cys Asn Asp Lys Thr Phe Asn Gly Lys Gly Pro Cys Lys Asn Val Ser 
225                 230                 235                 240 


Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu 
                245                 250                 255     


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Asp 
            260                 265                 270         


Asn Phe Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Lys Glu Ser 
        275                 280                 285             


Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile 
    290                 295                 300                 


His Ile Gly Pro Gly Arg Ala Phe Tyr Thr Thr Gly Glu Ile Ile Gly 
305                 310                 315                 320 


Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asp 
                325                 330                 335     


Thr Leu Lys Gln Ile Val Ile Lys Leu Arg Glu Gln Phe Glu Asn Lys 
            340                 345                 350         


Thr Ile Val Phe Asn His Ser Ser Gly Gly Asp Pro Glu Ile Val Met 
        355                 360                 365             


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln 
    370                 375                 380                 


Leu Phe Asn Ser Thr Trp Asn Asn Asn Thr Glu Gly Ser Asn Asn Thr 
385                 390                 395                 400 


Glu Gly Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn 
                405                 410                 415     


Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly 
            420                 425                 430         


Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
        435                 440                 445             


Gly Gly Ile Asn Glu Asn Gly Thr Glu Ile Phe Arg Pro Gly Gly Gly 
    450                 455                 460                 


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
465                 470                 475                 480 


Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val 
                485                 490                 495     


Val Gln Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly 
            500                 505                 510         


Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu 
        515                 520                 525             


Thr Val Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn 
    530                 535                 540                 


Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln Arg Met Leu Gln Leu Thr 
545                 550                 555                 560 


Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg 
                565                 570                 575     


Tyr Leu Gly Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys 
            580                 585                 590         


Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys 
        595                 600                 605             


Ser Leu Asp Arg Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg 
    610                 615                 620                 


Glu Ile Asp Asn Tyr Thr Ser Glu Ile Tyr Thr Leu Ile Glu Glu Ser 
625                 630                 635                 640 


Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 
                645                 650                 655     


Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Lys Trp Leu Trp Tyr 
            660                 665                 670         


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Leu 
        675                 680                 685             


Val Phe Thr Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser 
    690                 695                 700                 


Pro Leu Ser Phe Gln Thr Leu Leu Pro Ala Pro Arg Gly Pro Asp Arg 
705                 710                 715                 720 


Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser 
                725                 730                 735     


Gly Arg Leu Val Asn Gly Phe Leu Ala Leu Ile Trp Val Asp Leu Arg 
            740                 745                 750         


Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Thr 
        755                 760                 765             


Val Thr Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Val Leu 
    770                 775                 780                 


Lys Tyr Trp Trp Asn Leu Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn 
785                 790                 795                 800 


Ser Ala Val Ser Leu Leu Asn Ala Thr Ala Ile Ala Val Ala Glu Gly 
                805                 810                 815     


Thr Asp Arg Ile Ile Glu Ala Leu Gln Arg Thr Tyr Arg Ala Ile Leu 
            820                 825                 830         


His Ile Pro Thr Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
        835                 840                 845         


<210>  55
<211>  856
<212>  PRT
<213>  Simian-Human immunodeficiency virus

<400>  55

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Asn Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Thr 
            180                 185                 190         


Leu Thr Ser Cys Asn Thr Ser Val Ile Ser Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         


Arg Ser Val Asn Phe Met Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             


Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Ser Asn Asn Thr Ile 
    290                 295                 300                 


Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Met 
305                 310                 315                 320 


Gly Lys Ile Gly Asp Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            340                 345                 350         


Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Gly Asn Asn Glu 
    450                 455                 460                 


Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val 
        595                 600                 605             


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn 
    610                 615                 620                 


His Met Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 
625                 630                 635                 640 


Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
            660                 665                 670         


Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His 
705                 710                 715                 720 


Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser 
            740                 745                 750         


Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu 
    770                 775                 780                 


Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu 
785                 790                 795                 800 


Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
                805                 810                 815     


Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val 
            820                 825                 830         


Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Leu Glu Arg Ile Leu Leu 
    850                 855     


<210>  56
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c core with mutations

<400>  56

Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Glu Lys Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp 
    50                  55                  60                  


Val Ile Ser Ile Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn 
145                 150                 155                 160 


Leu Arg Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val 
                165                 170                 175     


Glu Ile Val Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu 
        195                 200                 205             


Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe Pro His Lys 
    210                 215                 220                 


Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr 
225                 230                 235                 240 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
                245                 250                 255     


Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu Pro Cys Arg 
            260                 265                 270         


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Ile Tyr 
        275                 280                 285             


Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly 
    290                 295                 300                 


Leu Leu Leu Leu Arg Asp Gly Gly Asp Thr Thr Asp Asn Thr Glu Ile 
305                 310                 315                 320 


Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                325                 330                 335     


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu 
            340                 345         


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  57

Gly Gly Ser Gly Ser Gly 
1               5       


<210>  58
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  58

Cys Gly Gly Gly 
1               


<210>  59
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  59

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  60

Ser Gly Arg Ala His Ala Gly 
1               5           


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(10)
<223>  Any one or all of amino acids 2-10 can be either present or 
       absent

<400>  61

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(10)
<223>  any one or all amino acids 2 through 10 can be either present or 
       abscent

<400>  62

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(10)
<223>  Any one or all of amino acids 2-10 can be either present or 
       absent

<400>  63

Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10  


<210>  64
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (3)..(20)
<223>  any one or all of amino acids 3 to 20 can either be presemt or 
       absent

<400>  64

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210>  65
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (5)..(40)
<223>  any one or all of amino acids 5 to 40 can be either present or 
       absent

<400>  65

Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
1               5                   10                  15      


Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
            20                  25                  30          


Gly Ser Ser Gly Gly Ser Ser Gly 
        35                  40  


<210>  66
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (4)..(30)
<223>  any one or all of amino acids 4 to 30 can be either present or 
       absent

<400>  66

Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            20                  25                  30  


<210>  67
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (4)..(30)
<223>  any one or all of amino acids 4 to 30 can be either present or 
       absent

<400>  67

Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly 
1               5                   10                  15      


Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser Ser 
            20                  25                  30  


<210>  68
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (3)..(20)
<223>  any one or all of amino acids 3 to 20 can be either present or 
       absent

<400>  68

Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala 
            20  


<210>  69
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  69

Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
1               5                   10                  15      


Glu Glu Val Val Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr 
            20                  25                  30          


Ile Ile Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly Ala 
        35                  40                  45              


Gly His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln 
    50                  55                  60                  


Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly Asn Asn Lys Thr Ile Ile 
65                  70                  75                  80  


Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His Ser Phe 
                85                  90                  95      


Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser Thr Gln Leu Phe Asn 
            100                 105                 110         


Ser Thr Trp Phe Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr 
        115                 120                 125             


Glu Gly Ser Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro 
    130                 135                 140                 


His Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
145                 150                 155                 160 


Asn Ser Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met 
                165                 170                 175     


Arg Asp Asn Trp Arg Ser Glu 
            180             


<210>  70
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  70

Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
1               5                   10                  15      


Glu Glu Val Val Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr 
            20                  25                  30          


Ile Ile Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly Ala 
        35                  40                  45              


Gly His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln 
    50                  55                  60                  


Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly Asn Asn Lys Thr Ile Ile 
65                  70                  75                  80  


Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His Ser Phe 
                85                  90                  95      


Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn 
            100                 105                 110         


Ser Thr Trp Phe Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr 
        115                 120                 125             


Glu Gly Ser Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro 
    130                 135                 140                 


His Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
145                 150                 155                 160 


Asn Ser Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met 
                165                 170                 175     


Arg Asp Asn Trp Arg Ser Glu 
            180             


<210>  71
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  71

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn 
        35                  40                  45              


Trp Arg Ser Gly Leu Ser Gly Pro Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  72
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  72

Gly Glu Phe Phe Tyr Cys Asp Ser Thr Gln Leu Phe Asn Ser Thr Trp 
1               5                   10                  15      


Phe Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser 
            20                  25                  30          


Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
        35                  40                  45              


Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn 
    50                  55                  60                  


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn 
65                  70                  75                  80  


Trp Arg Ser Gly Leu Ser Gly Pro Val Val Ser Thr Gln Leu Leu Leu 
                85                  90                  95      


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
            100                 105                 110         


Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Thr Ser Val Glu 
        115                 120                 125             


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
    130                 135                 140                 


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
145                 150                 155                 160 


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
                165                 170                 175     


Ile Val Thr His Ser Phe Asn Cys Gly 
            180                 185 


<210>  73
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  73

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  74
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  74

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Cys Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Cys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  75
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  75

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Ala Gly Met 
        35                  40                  45              


Pro Arg Cys Gly Gly Gly Ala Val Ser Thr Gln Leu Leu Leu Asn Gly 
    50                  55                  60                  


Ser Leu Ala Glu Glu Glu Val Val Cys Arg Ser Val Asn Phe Thr Asp 
65                  70                  75                  80  


Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu Ile Asn 
                85                  90                  95      


Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn 
            100                 105                 110         


Thr Leu Lys Gln Ile Ala Ser Cys Leu Arg Glu Gln Phe Gly Asn Asn 
        115                 120                 125             


Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
    130                 135                 140                 


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser Thr 
145                 150                 155                 160 


Gln Leu Phe Asn Ser Thr Trp Phe 
                165             


<210>  76
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  76

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asp Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asp Thr Ser Val Glu 
                85                  90                  95      


Ile Asp Cys Thr Gly Ala Gly His Cys Asp Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asp Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asp Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp Ser 
                165                 170                 175 


<210>  77
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  77

Gly Glu Phe Phe Tyr Cys Asp Ser Thr Gln Leu Phe Asn Ser Thr Trp 
1               5                   10                  15      


Phe Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser 
            20                  25                  30          


Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
        35                  40                  45              


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
    50                  55                  60                  


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
65                  70                  75                  80  


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
                85                  90                  95      


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
            100                 105                 110         


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
        115                 120                 125             


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
    130                 135                 140                 


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
145                 150                 155                 160 


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
                165                 170                 175     


Ile Val Thr His Ser Phe Asn Cys Gly 
            180                 185 


<210>  78
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  78

Gly Glu Phe Phe Tyr Cys Asp Ser Thr Gln Leu Phe Asn Ser Thr Trp 
1               5                   10                  15      


Phe Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser 
            20                  25                  30          


Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
        35                  40                  45              


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
    50                  55                  60                  


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Cys Gly 
65                  70                  75                  80  


Ala Arg Ser Gly Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
                85                  90                  95      


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
            100                 105                 110         


Thr Asp Asn Ala Lys Cys Ile Ile Val Gln Leu Asn Thr Ser Val Glu 
        115                 120                 125             


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
    130                 135                 140                 


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
145                 150                 155                 160 


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
                165                 170                 175     


Ile Val Thr His Ser Phe Asn Cys Gly 
            180                 185 


<210>  79
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  79

Gly Glu Phe Phe Tyr Cys Asp Ser Thr Gln Leu Phe Asn Ser Thr Trp 
1               5                   10                  15      


Phe Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser 
            20                  25                  30          


Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
        35                  40                  45              


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
    50                  55                  60                  


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
65                  70                  75                  80  


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
                85                  90                  95      


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Cys Arg Ser Val Asn Phe 
            100                 105                 110         


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
        115                 120                 125             


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
    130                 135                 140                 


Asn Asn Thr Leu Lys Gln Ile Ala Ser Cys Leu Arg Glu Gln Phe Gly 
145                 150                 155                 160 


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
                165                 170                 175     


Ile Val Thr His Ser Phe Asn Cys Gly 
            180                 185 


<210>  80
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  80

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Thr Ser Asp 
            20                  25                  30          


Asp Lys Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp Ser 
                165                 170                 


<210>  81
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  81

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gly Gly Gly Ile Ser Asp 
            20                  25                  30          


Asp Lys Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ser Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Lys Thr Ile Ile Phe Ser Gln Ser Leu Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp Ser 
                165                 170                 


<210>  82
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  82

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gly Gly Gly Ile Ser Asp 
            20                  25                  30          


Asp Lys Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ser Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Lys Thr Ile Ile Phe Ser Gln Ser Leu Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp Ser 
                165                 170                 


<210>  83
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  83

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gly Gly Gly Ile Ser Asp 
            20                  25                  30          


Asp Lys Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ser Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Lys Thr Ile Ile Phe Ser Gln Ser Leu Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp 
                165                 170             


<210>  84
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  84

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gly Gly Gly Ile Ser Asp 
            20                  25                  30          


Asp Lys Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ser Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Ser Gln Ser Leu Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp 
                165                 170             


<210>  85
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  85

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gly Gly Gly Ile Ser Asp 
            20                  25                  30          


Asp Asp Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ser Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Ser Gln Ser Leu Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp 
                165                 170             


<210>  86
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  86

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Ala Gly Gly Ile Ser Asp 
            20                  25                  30          


Asp Asn Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ser Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Ser Gln Ser Leu Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp 
                165                 170             


<210>  87
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  87

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gly Gly Gly Ile Ser Asp 
            20                  25                  30          


Asp Asn Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ser Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Ser Gln Ser Leu Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp 
                165                 170             


<210>  88
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  88

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gly Gly Gly Val Ser Asp 
            20                  25                  30          


Asp Asp Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Ser Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp 
                165                 170             


<210>  89
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  89

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gly Gly Gly Val Ser Asp 
            20                  25                  30          


Asp Asp Thr Glu Ile Phe Arg Pro Ala Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Ser Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr Trp 
                165                 170             


<210>  90
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  90

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gly Gly Gly Val Ser Asp 
            20                  25                  30          


Asp Asp Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Ser Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp 
                165                 170 


<210>  91
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  91

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asp Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  92
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  92

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asp Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  93
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  93

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asp Glu Ser Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  94
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  94

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asp Glu Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  95
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  95

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asp Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  96
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  96

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asp Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  97
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  97

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asp Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  98
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  98

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asp Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  99
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  99

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asp Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asp Thr Ser Val Glu 
                85                  90                  95      


Ile Asp Cys Thr Gly Ala Gly His Cys Asp Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asp Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asp Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asp Ser Thr Trp Phe Asp Ser Thr 
                165                 170         


<210>  100
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  100

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asn Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  101
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  101

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  102
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  102

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asn Glu Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  103
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  103

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asn Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  104
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  104

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asn Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  105
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  105

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asn Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  106
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  106

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asn Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  107
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  107

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Val Ser Asn 
            20                  25                  30          


Asn Glu Thr Glu Ile Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  108
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  108

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Ala Gly Gly Val Ser Asp 
            20                  25                  30          


Asn Asn Thr Glu Ile Phe Phe Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Ser Gln Ser Thr Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  109
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  109

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Gly Arg Ala Gly Gly Ala Ser Asp 
            20                  25                  30          


Asp Asn Thr Glu Ile Phe Tyr Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Ser Gln Ser Thr Gly Gly Asp Pro Glu Ile 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
                165                 170             


<210>  110
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  110

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Ala Gly Gly Val Ser Asn 
            20                  25                  30          


Asn Glu Thr Glu Ile Phe Phe Pro Ser Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asp Phe 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Arg Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  111
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  111

Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Glu Leu Glu Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp 
    50                  55                  60                  


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Gly Gly Ser Val Ile Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
            100                 105                 110         


Lys Asp Lys Lys Phe Asn Gly Lys Gly Pro Cys Ser Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn 
145                 150                 155                 160 


Phe Ala Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Ser Val 
                165                 170                 175     


Glu Ile Asn Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asp Ile Arg Gln Ala His Cys Asn Leu Ser Arg Ala Lys Trp Asn Asp 
        195                 200                 205             


Thr Leu Asn Lys Ile Val Ile Lys Leu Arg Glu Gln Phe Gly Asn Lys 
    210                 215                 220                 


Thr Ile Val Phe Lys His Ser Ser Gly Gly Asp Pro Glu Ile Val Thr 
225                 230                 235                 240 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln 
                245                 250                 255     


Leu Phe Asn Ser Thr Trp Asn Val Thr Glu Glu Ser Asn Asn Thr Val 
            260                 265                 270         


Glu Asn Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn 
        275                 280                 285             


Met Trp Gln Lys Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Arg Gly 
    290                 295                 300                 


Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
305                 310                 315                 320 


Gly Gly Pro Glu Asp Asn Lys Thr Glu Val Phe Arg Pro Gly Gly Gly 
                325                 330                 335     


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
            340                 345                 350         


Lys Ile Glu 
        355 


<210>  112
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Env

<400>  112

Val Trp Lys Asp Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala His Glu Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Glu Leu Lys Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp 
    50                  55                  60                  


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Gly Gly Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
            100                 105                 110         


Lys Asp Lys Lys Phe Asn Gly Lys Gly Pro Cys Ser Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asp 
145                 150                 155                 160 


Phe Arg Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Glu Ser Val 
                165                 170                 175     


Glu Ile Asn Cys Thr Gly Ala Gly His Cys Asn Leu Ser Arg Ala Lys 
            180                 185                 190         


Trp Asn Asp Thr Leu Asn Lys Ile Val Ile Lys Leu Arg Glu Gln Phe 
        195                 200                 205             


Gly Asn Lys Thr Ile Val Phe Lys His Ser Ser Gly Gly Asp Pro Glu 
    210                 215                 220                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
225                 230                 235                 240 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Asn Val Thr Glu Glu Ser Asn 
                245                 250                 255     


Asn Thr Val Glu Asn Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln 
            260                 265                 270         


Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro 
        275                 280                 285             


Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile 
    290                 295                 


<210>  113
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  113

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  114
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  114

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  115
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  115

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  116
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  116

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile 
    130                 135                 140                 


Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 


<210>  117
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  117

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  118
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  118

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Ser Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Trp Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  119
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hxb2_core_C4b nanoparticle

<400>  119

Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Asp Thr Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Val Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asp Met Val Glu Gln Met His Glu Asp 
    50                  55                  60                  


Ile Ile Ser Leu Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn 
145                 150                 155                 160 


Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Thr Ser Val 
                165                 170                 175     


Glu Ile Asn Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn 
        195                 200                 205             


Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly Asn Asn 
    210                 215                 220                 


Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
225                 230                 235                 240 


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr 
                245                 250                 255     


Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser Thr Glu Gly 
            260                 265                 270         


Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu Pro Cys Arg Ile 
        275                 280                 285             


Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys Ala Met Tyr Ala 
    290                 295                 300                 


Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu 
305                 310                 315                 320 


Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu Ser Glu Ile Phe 
                325                 330                 335     


Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
            340                 345                 350         


Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Ser Ser Lys Lys Gln 
        355                 360                 365             


Gly Asp Ala Asp Val Cys Gly Glu Val Ala Tyr Ile Gln Ser Val Val 
    370                 375                 380                 


Ser Asp Cys His Val Pro Thr Ala Glu Leu Arg Thr Leu Leu Glu Ile 
385                 390                 395                 400 


Arg Lys Leu Phe Leu Glu Ile Gln Lys Leu Lys Val Glu Leu Gln Gly 
                405                 410                 415     


Leu Ser Lys Glu 
            420 


<210>  120
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V3 Linker

<400>  120

Gly Gly Ser Gly Ser Gly Gly 
1               5           


<210>  121
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  121

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Asn Cys Ser Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  122
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  122

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Asn Ala Ser Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  123
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  123

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Asn Val Thr Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  124
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  124

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Asn Phe Ser 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  125
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  125

Asp Thr Ile Thr Leu Pro Cys Asn Pro Ser Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  126
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  126

Asp Thr Ile Thr Leu Pro Cys Arg Asn Ala Thr Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  127
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  127

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Asn Glu Thr Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  128
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  128

Asp Thr Ile Thr Leu Pro Cys Asn Pro Ser Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Asn Ala Ser Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Asn Glu Thr Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  129
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  129

Asp Thr Ile Thr Leu Pro Cys Asn Pro Ser Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Asn Cys Ser Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Asn Glu Thr Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  130
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  130

Asp Thr Ile Thr Leu Pro Cys Asn Pro Ser Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Asn Cys Ser Ile Ala Gly Asn Val Thr Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Asn Glu Thr Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  131
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  131

Asp Thr Ile Thr Leu Pro Cys Asn Pro Ser Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Asn Cys Ser Ile Ala Gly Thr Val Val Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Asn Phe Ser 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Asn Glu Thr Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  132
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Boost Env with N276 glycosylation

<400>  132

Asp Thr Ile Thr Leu Pro Cys Asn Pro Ser Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Asp Gly Gly Asn Ser Asn 
            20                  25                  30          


Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Ile 
        35                  40                  45              


Ala Asn Cys Ser Ile Ala Gly Asn Val Thr Ser Thr Gln Leu Leu Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe 
65                  70                  75                  80  


Thr Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Asn Phe Ser 
        115                 120                 125             


Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
    130                 135                 140                 


Ile Val Thr His Ser Phe Asn Cys Gly Asn Glu Thr Phe Tyr Cys Asn 
145                 150                 155                 160 


Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser 
                165                 170                 175 


<210>  133
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ferritin fusion sequence

<400>  133

Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Glu Lys Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp 
    50                  55                  60                  


Val Ile Ser Ile Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn 
145                 150                 155                 160 


Leu Arg Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val 
                165                 170                 175     


Glu Ile Val Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu 
        195                 200                 205             


Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe Pro His Lys 
    210                 215                 220                 


Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr 
225                 230                 235                 240 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
                245                 250                 255     


Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu Pro Cys Arg 
            260                 265                 270         


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Ile Tyr 
        275                 280                 285             


Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly 
    290                 295                 300                 


Leu Leu Leu Leu Arg Asp Gly Gly Asp Thr Thr Asp Asn Thr Glu Ile 
305                 310                 315                 320 


Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                325                 330                 335     


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ser Gly Gly Ser 
            340                 345                 350         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        355                 360                 365             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    370                 375                 380                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
385                 390                 395                 400 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                405                 410                 415     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            420                 425                 430         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        435                 440                 445             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    450                 455                 460                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
465                 470                 475                 480 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                485                 490                 495     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            500                 505                 510         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        515                 520                 525             


<210>  134
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ferritin fusion sequence

<400>  134

Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser 
1               5                   10                  15      


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
            20                  25                  30          


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
        35                  40                  45              


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
    50                  55                  60                  


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
65                  70                  75                  80  


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
                85                  90                  95      


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
            100                 105                 110         


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
        115                 120                 125             


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
    130                 135                 140                 


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
145                 150                 155                 160 


Arg Lys Ser 
            


<210>  135
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ferritin fusion sequence

<400>  135

Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser Ser Asn Leu Tyr Met 
1               5                   10                  15      


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
            20                  25                  30          


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
        35                  40                  45              


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
    50                  55                  60                  


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
65                  70                  75                  80  


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
                85                  90                  95      


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
            100                 105                 110         


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
        115                 120                 125             


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
    130                 135                 140                 


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
145                 150                 155             


<210>  136
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ferritin fusion sequence

<400>  136

Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
1               5                   10                  15      


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
            20                  25                  30          


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
        35                  40                  45              


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
    50                  55                  60                  


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
65                  70                  75                  80  


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
                85                  90                  95      


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
            100                 105                 110         


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
        115                 120                 125             


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
    130                 135                 140                 


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
145                 150                 155                 160 


Arg Lys Ser 
            


<210>  137
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c core + linker + ferritin construct

<400>  137

Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Glu Lys Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp 
    50                  55                  60                  


Val Ile Ser Ile Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn 
145                 150                 155                 160 


Leu Arg Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val 
                165                 170                 175     


Glu Ile Val Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu 
        195                 200                 205             


Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe Pro His Lys 
    210                 215                 220                 


Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr 
225                 230                 235                 240 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
                245                 250                 255     


Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu Pro Cys Arg 
            260                 265                 270         


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Ile Tyr 
        275                 280                 285             


Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly 
    290                 295                 300                 


Leu Leu Leu Leu Arg Asp Gly Gly Asp Thr Thr Asp Asn Thr Glu Ile 
305                 310                 315                 320 


Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                325                 330                 335     


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ser Gly Gly Ser 
            340                 345                 350         


Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu 
        355                 360                 365             


Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met 
    370                 375                 380                 


Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu 
385                 390                 395                 400 


Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu 
                405                 410                 415     


Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile 
            420                 425                 430         


Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys 
        435                 440                 445             


Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val 
    450                 455                 460                 


Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln 
465                 470                 475                 480 


Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile 
                485                 490                 495     


Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu 
            500                 505                 510         


Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
        515                 520                 525             


<210>  138
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  138

Ser Gly Arg Ala His Ala Gly Trp Glu Thr Pro Glu Gly Cys Glu Gln 
1               5                   10                  15      


Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro Asn Pro Glu Asp 
            20                  25                  30          


Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu Glu Ile Glu Gln 
        35                  40                  45              


Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr Leu Asp Lys Glu 
    50                  55                  60                  


Leu Val Pro Arg 
65              


<210>  139
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  139

Lys Lys Gln Gly Asp Ala Asp Val Cys Gly Glu Val Ala Tyr Ile Gln 
1               5                   10                  15      


Ser Val Val Ser Asp Cys His Val Pro Thr Ala Glu Leu Arg Thr Leu 
            20                  25                  30          


Leu Glu Ile Arg Lys Leu Phe Leu Glu Ile Gln Lys Leu Lys Val Glu 
        35                  40                  45              


Leu Gln Gly Leu Ser Lys Glu 
    50                  55  


<210>  140
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  140

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  141
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  141

Trp Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu 
1               5                   10                  15      


Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val 
            20                  25                  30          


Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser 
        35                  40                  45              


Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55              


<210>  142
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  142

Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro Asn 
1               5                   10                  15      


Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu Glu 
            20                  25                  30          


Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr Leu 
        35                  40                  45              


Asp Lys Glu Leu 
    50          


<210>  143
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  143

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Tyr Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  144
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  144

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Ala Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  145
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  145

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Ala Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Arg Gln Ser Thr Trp Asp Lys Glu Leu 
    50                  55          


<210>  146
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  146

Glu Val Pro Glu Gly Cys Glu Gln Val Gln Ala Gly Arg Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Ala Asp Pro Tyr Glu Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Leu Leu Glu Leu Gln Arg Asp Lys Ala 
        35                  40                  45              


Arg Lys Ser Ser Val Leu Arg Gln Leu 
    50                  55          


<210>  147
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  147

Val Val Pro Glu Gly Cys Glu His Ile Leu Lys Gly Arg Lys Thr Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Ser Leu Asp Ile Glu Leu Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Lys Glu Ser Thr Val Gln Ser Pro Val 
    50                  55          


<210>  148
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  148

Glu Val Pro Lys Asp Cys Glu His Val Phe Ala Gly Lys Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Ser Asn Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Thr Leu Glu Ile Lys Gln Leu Gln Leu Gln Ile Asp Lys Ala 
        35                  40                  45              


Lys His Val Asp Arg Glu Leu 
    50                  55  


<210>  149
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  149

Glu Tyr Pro Glu Asp Cys Glu Gln Val His Glu Gly Lys Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Leu Glu Glu Ile Lys Leu Ala Leu Glu Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Thr Lys Leu Leu Glu Leu Gln Ile Asp Lys Glu 
        35                  40                  45              


Lys Lys Ala Lys Ala Lys Tyr Ser Ile 
    50                  55          


<210>  150
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  150

Glu Tyr Pro Glu Asp Cys Glu Gln Val His Glu Gly Lys Lys Leu Met 
1               5                   10                  15      


Glu Cys Leu Pro Thr Leu Glu Glu Ile Lys Leu Ala Leu Ala Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Thr Asn Leu Leu Glu Leu Gln Ile Asp Lys Glu 
        35                  40                  45              


Lys Lys Ala Lys Ala Lys Tyr Ser Thr 
    50                  55          


<210>  151
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  151

Glu Ile Ala Glu Gly Cys Glu Gln Val Leu Ala Gly Arg Lys Ile Met 
1               5                   10                  15      


Gln Cys Leu Pro Lys Pro Glu Asp Val Arg Thr Ala Leu Glu Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Lys Lys Leu Glu Lys Glu 
        35                  40                  45              


Glu Lys Cys Thr Pro Glu Val Gln Glu 
    50                  55          


<210>  152
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  152

Glu Tyr Pro Glu Gly Cys Glu Gln Val Val Thr Gly Arg Lys Leu Leu 
1               5                   10                  15      


Gln Cys Leu Ser Arg Pro Glu Glu Val Lys Leu Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Ile Leu Gln Thr Asn Lys Leu Lys Lys 
        35                  40                  45              


Glu Ala Phe Leu Leu Arg Glu Arg Glu Lys Asn Val Thr Cys Asp Phe 
    50                  55                  60                  


Asn Pro Glu 
65          


<210>  153
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  153

Glu Tyr Pro Glu Gly Cys Glu Gln Val Val Thr Gly Arg Lys Leu Leu 
1               5                   10                  15      


Lys Cys Leu Ser Arg Pro Glu Glu Val Lys Leu Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Ala Leu Leu Glu Leu Gln Ile Asp Lys Pro 
        35                  40                  45              


Lys Asp Ala Ser 
    50          


<210>  154
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  154

Glu Val Pro Glu Asn Cys Glu Gln Val Ile Val Gly Lys Lys Leu Met 
1               5                   10                  15      


Lys Cys Leu Ser Asn Pro Asp Glu Ala Gln Met Ala Leu Gln Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ala Glu Leu Leu Arg Leu Gln Ile Val Lys Ala 
        35                  40                  45              


Arg Gln Gly Ser 
    50          


<210>  155
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  155

Glu Ala Ser Glu Asp Leu Lys Pro Ala Leu Thr Gly Asn Lys Thr Met 
1               5                   10                  15      


Gln Tyr Val Pro Asn Ser His Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Thr Leu Glu Val Glu Leu Leu Gln Leu Gln Ile Gln Lys Glu 
        35                  40                  45              


Lys His Thr Glu Ala His 
    50                  


<210>  156
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  156

Val Ser Ala Glu Val Cys Glu Ala Val Phe Lys Gly Gln Lys Leu Leu 
1               5                   10                  15      


Lys Cys Leu Pro Asn Ala Met Glu Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Lys Leu Glu Gln Glu Lys Arg Lys Leu 
        35                  40                  45              


Glu Ile Ala 
    50      


<210>  157
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  157

Glu Val Pro Glu Glu Cys Lys Gln Val Ala Ala Gly Arg Lys Leu Leu 
1               5                   10                  15      


Glu Cys Leu Pro Asn Pro Ser Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Lys Glu Lys Tyr Val Lys 
        35                  40                  45              


Ile Gln Glu Lys Phe Ser Lys Lys Glu Met Lys Gln Leu Thr Ser Ala 
    50                  55                  60                  


Leu His 
65      


<210>  158
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  158

Glu Val Leu Glu Asp Cys Arg Ile Val Ser Arg Gly Ala Gln Leu Leu 
1               5                   10                  15      


His Cys Leu Ser Ser Pro Glu Asp Val His Arg Ala Leu Lys Val Tyr 
            20                  25                  30          


Lys Leu Phe Leu Glu Ile Glu Arg Leu Glu His Gln Lys Glu Lys Trp 
        35                  40                  45              


Ile Gln Leu His Arg Lys Pro Gln Ser Met Lys 
    50                  55                  


<210>  159
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  159

Glu Gly Pro Glu Asp Cys Glu Ile Val Asn Lys Gly Arg Gln Leu Leu 
1               5                   10                  15      


Gln Cys Leu Ser Ser Pro Glu Asp Val Gln Arg Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Arg Leu Glu Gln Gln Arg Glu Lys Arg 
        35                  40                  45              


Thr Ser Val His Arg Lys Ala His Tyr Thr Lys Val Asp Gly Pro 
    50                  55                  60              


<210>  160
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  160

Glu Ala Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Arg Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Ser Pro Glu Asp Val Lys Val Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Lys Glu Arg Asp Lys Leu 
        35                  40                  45              


Met Asn Thr His Gln Lys Phe Ser Glu Lys Glu Glu Met Lys Asp Leu 
    50                  55                  60                  


Phe Phe Pro 
65          


<210>  161
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  161

Glu Val Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Leu Leu Glu Leu Gln Ile Asp Lys Ala 
        35                  40                  45              


Arg Gln Gly Ser 
    50          


<210>  162
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  162

Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro 
1               5                   10                  15      


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
            20                  25                  30          


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser 
        35                  40                  45          


<210>  163
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  163

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser 
    50      


<210>  164
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  164

Gly Ser Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Ser Leu Pro 
1               5                   10                  15      


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
            20                  25                  30          


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr 
        35                  40                  45              


Leu Asp Lys Glu Leu 
    50              


<210>  165
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  165

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Thr Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  166
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  166

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  167
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  167

Glu Gly Cys Glu Gln Ile Leu Thr Gly Lys Arg Leu Met Gln Cys Leu 
1               5                   10                  15      


Pro Asp Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr Lys Leu Ser 
            20                  25                  30          


Leu Glu Ile Lys Gln Leu Glu Leu Gln Arg Asp Arg Ala Arg Gln Ser 
        35                  40                  45              


Thr Leu 
    50  


<210>  168
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  168

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  169
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  169

Glu Gly Cys Glu Gln Ile Leu Thr Gly Lys Arg Leu Met Gln Cys Leu 
1               5                   10                  15      


Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr Lys Leu Ser 
            20                  25                  30          


Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Arg Ala Arg Gln Ser 
        35                  40                  45              


Thr Leu Asp Lys 
    50          


<210>  170
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  170

Trp Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu 
1               5                   10                  15      


Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val 
            20                  25                  30          


Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser 
        35                  40                  45              


Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu Val Pro Arg 
    50                  55                  60      


<210>  171
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  171

Ala His Ala Gly Trp Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr 
1               5                   10                  15      


Gly Lys Arg Leu Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met 
            20                  25                  30          


Ala Leu Glu Val Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu 
        35                  40                  45              


Gln Arg Asp Ser Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55                  60          


<210>  172
<211>  56
<212>  PRT
<213>  Gallus gallus

<400>  172

Ser Lys Lys Gln Gly Asp Ala Asp Val Cys Gly Glu Val Ala Tyr Ile 
1               5                   10                  15      


Gln Ser Val Val Ser Asp Cys His Val Pro Thr Glu Asp Val Lys Thr 
            20                  25                  30          


Leu Leu Glu Ile Arg Lys Leu Phe Leu Glu Ile Gln Lys Leu Lys Val 
        35                  40                  45              


Glu Leu Gln Gly Leu Ser Lys Glu 
    50                  55      


<210>  173
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4b multimerization domain

<400>  173

Ser Lys Lys Gln Gly Asp Ala Asp Val Cys Gly Glu Val Ala Tyr Ile 
1               5                   10                  15      


Gln Ser Val Val Ser Asp Cys His Val Pro Thr Ala Glu Leu Arg Thr 
            20                  25                  30          


Leu Leu Glu Ile Arg Lys Leu Phe Leu Glu Ile Gln Lys Leu Lys Val 
        35                  40                  45              


Glu Leu Gln Gly Leu Ser Lys 
    50                  55  


<210>  174
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c core Env and a C4b multimerization domain

<400>  174

Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Glu Lys Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp 
    50                  55                  60                  


Val Ile Ser Ile Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn 
145                 150                 155                 160 


Leu Arg Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val 
                165                 170                 175     


Glu Ile Val Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu 
        195                 200                 205             


Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe Pro His Lys 
    210                 215                 220                 


Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr 
225                 230                 235                 240 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
                245                 250                 255     


Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu Pro Cys Arg 
            260                 265                 270         


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Ile Tyr 
        275                 280                 285             


Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly 
    290                 295                 300                 


Leu Leu Leu Leu Arg Asp Gly Gly Asp Thr Thr Asp Asn Thr Glu Ile 
305                 310                 315                 320 


Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                325                 330                 335     


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Ser Gly Arg Ala His 
            340                 345                 350         


Ala Gly Trp Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys 
        355                 360                 365             


Arg Leu Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu 
    370                 375                 380                 


Glu Val Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg 
385                 390                 395                 400 


Asp Ser Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu Val Pro Arg 
                405                 410                 415 


<210>  175
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c core-gp120 without signal sequence

<400>  175

Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Glu Lys Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp 
    50                  55                  60                  


Val Ile Ser Ile Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn 
145                 150                 155                 160 


Leu Ser Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val 
                165                 170                 175     


Glu Ile Val Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu 
        195                 200                 205             


Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe Pro His Lys 
    210                 215                 220                 


Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr 
225                 230                 235                 240 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
                245                 250                 255     


Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu Pro Cys Arg 
            260                 265                 270         


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Ile Tyr 
        275                 280                 285             


Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly 
    290                 295                 300                 


Leu Leu Leu Leu Arg Asp Gly Gly Asn Thr Thr Asn Asn Thr Glu Ile 
305                 310                 315                 320 


Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                325                 330                 335     


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu 
            340                 345         


<210>  176
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eOD-GT8-hisavi without signal sequence

<400>  176

Asp Thr Ile Thr Leu Pro Cys Arg Pro Ala Pro Pro Pro His Cys Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gly Leu Ile Leu Thr Arg Gln Gly Gly Tyr Ser Asn 
            20                  25                  30          


Asp Asn Thr Val Ile Phe Arg Pro Ser Gly Gly Asp Trp Arg Asp Ile 
        35                  40                  45              


Ala Arg Cys Gln Ile Ala Gly Thr Val Val Ser Thr Gln Leu Phe Leu 
    50                  55                  60                  


Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asp Trp 
65                  70                  75                  80  


Arg Asp Asn Ala Lys Ser Ile Cys Val Gln Leu Asn Thr Ser Val Glu 
                85                  90                  95      


Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala Lys Trp 
            100                 105                 110         


Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Tyr Gly 
        115                 120                 125             


Asn Lys Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Asp Pro Glu Phe 
    130                 135                 140                 


Val Asn His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asp Ser 
145                 150                 155                 160 


Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
                165                 170         


<210>  177
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c:BG505_WT-Sosip without signal sequence

<400>  177

Glu Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
1               5                   10                  15      


Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys 
            20                  25                  30          


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
        35                  40                  45              


Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
    50                  55                  60                  


Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp Val Ile Ser Ile 
65                  70                  75                  80  


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
                85                  90                  95      


Thr Leu Asn Cys Thr Asn Val Asn Val Thr Ser Asn Ser Thr Asn Val 
            100                 105                 110         


Asn Ser Ser Ser Thr Asp Asn Thr Thr Leu Gly Glu Ile Lys Asn Cys 
        115                 120                 125             


Ser Phe Asp Ile Thr Thr Glu Ile Arg Asp Lys Thr Arg Lys Glu Tyr 
    130                 135                 140                 


Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asp Asn Ser Ser Asn 
145                 150                 155                 160 


Pro Asn Ser Ser Asn Thr Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr 
                165                 170                 175     


Cys Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His 
            180                 185                 190         


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr 
        195                 200                 205             


Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr 
    210                 215                 220                 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
225                 230                 235                 240 


Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn Leu Ser Asp Asn 
                245                 250                 255     


Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val Glu Ile Val Cys 
            260                 265                 270         


Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly 
        275                 280                 285             


Gln Thr Phe Tyr Ala Thr Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr 
    290                 295                 300                 


Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu Ala Val Asn Gln Val Lys 
305                 310                 315                 320 


Lys Lys Leu Lys Glu His Phe Pro His Lys Asn Ile Ser Phe Gln Ser 
                325                 330                 335     


Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly 
            340                 345                 350         


Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Asp Thr Ile 
        355                 360                 365             


Ser Asn Ala Thr Ile Met Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn 
    370                 375                 380                 


Met Trp Gln Glu Val Gly Lys Cys Ile Tyr Ala Pro Pro Ile Lys Gly 
385                 390                 395                 400 


Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly Leu Leu Leu Leu Arg Asp 
                405                 410                 415     


Gly Gly Asn Thr Thr Asn Asn Thr Glu Ile Phe Arg Pro Gly Gly Gly 
            420                 425                 430         


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
        435                 440                 445             


Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Cys Lys Arg Arg Val 
    450                 455                 460                 


Val Gly Arg Arg Arg Arg Arg Arg Ala Val Gly Ile Gly Ala Val Phe 
465                 470                 475                 480 


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met 
                485                 490                 495     


Thr Leu Thr Val Gln Ala Arg Asn Leu Leu Ser Gly Ile Val Gln Gln 
            500                 505                 510         


Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys 
        515                 520                 525             


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
    530                 535                 540                 


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
545                 550                 555                 560 


Gly Lys Leu Ile Cys Cys Thr Asn Val Pro Trp Asn Ser Ser Trp Ser 
                565                 570                 575     


Asn Arg Asn Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp 
            580                 585                 590         


Asp Lys Glu Ile Ser Asn Tyr Thr Gln Ile Ile Tyr Gly Leu Leu Glu 
        595                 600                 605             


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
    610                 615                 620                 


Asp 
625 


<210>  178
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c:BG505_TM-Sosip without signal sequence

<400>  178

Glu Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
1               5                   10                  15      


Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys 
            20                  25                  30          


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
        35                  40                  45              


Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
    50                  55                  60                  


Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp Val Ile Ser Ile 
65                  70                  75                  80  


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
                85                  90                  95      


Thr Leu Asn Cys Thr Asn Val Asn Val Thr Ser Asn Ser Thr Asn Val 
            100                 105                 110         


Asn Ser Ser Ser Thr Asp Asn Thr Thr Leu Gly Glu Ile Lys Asn Cys 
        115                 120                 125             


Ser Phe Asp Ile Thr Thr Glu Ile Arg Asp Lys Thr Arg Lys Glu Tyr 
    130                 135                 140                 


Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asp Asn Ser Ser Asn 
145                 150                 155                 160 


Pro Asn Ser Ser Asn Thr Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr 
                165                 170                 175     


Cys Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His 
            180                 185                 190         


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr 
        195                 200                 205             


Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr 
    210                 215                 220                 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
225                 230                 235                 240 


Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn Leu Ala Asp Asn 
                245                 250                 255     


Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val Glu Ile Val Cys 
            260                 265                 270         


Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly 
        275                 280                 285             


Gln Thr Phe Tyr Ala Thr Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr 
    290                 295                 300                 


Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu Ala Val Asn Gln Val Lys 
305                 310                 315                 320 


Lys Lys Leu Lys Glu His Phe Pro His Lys Asn Ile Ser Phe Gln Ser 
                325                 330                 335     


Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly 
            340                 345                 350         


Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Asp Thr Ile 
        355                 360                 365             


Ser Asn Ala Thr Ile Met Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn 
    370                 375                 380                 


Met Trp Gln Glu Val Gly Lys Cys Ile Tyr Ala Pro Pro Ile Lys Gly 
385                 390                 395                 400 


Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly Leu Leu Leu Leu Arg Asp 
                405                 410                 415     


Gly Gly Asn Thr Ala Asn Asn Ala Glu Ile Phe Arg Pro Gly Gly Gly 
            420                 425                 430         


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
        435                 440                 445             


Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Cys Lys Arg Arg Val 
    450                 455                 460                 


Val Gly Arg Arg Arg Arg Arg Arg Ala Val Gly Ile Gly Ala Val Phe 
465                 470                 475                 480 


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met 
                485                 490                 495     


Thr Leu Thr Val Gln Ala Arg Asn Leu Leu Ser Gly Ile Val Gln Gln 
            500                 505                 510         


Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys 
        515                 520                 525             


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
    530                 535                 540                 


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
545                 550                 555                 560 


Gly Lys Leu Ile Cys Cys Thr Asn Val Pro Trp Asn Ser Ser Trp Ser 
                565                 570                 575     


Asn Arg Asn Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp 
            580                 585                 590         


Asp Lys Glu Ile Ser Asn Tyr Thr Gln Ile Ile Tyr Gly Leu Leu Glu 
        595                 600                 605             


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
    610                 615                 620                 


Asp 
625 


<210>  179
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c:BG505_SM-Sosip without signal sequence

<400>  179

Glu Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
1               5                   10                  15      


Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys 
            20                  25                  30          


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
        35                  40                  45              


Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
    50                  55                  60                  


Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp Val Ile Ser Ile 
65                  70                  75                  80  


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
                85                  90                  95      


Thr Leu Asn Cys Thr Asn Val Asn Val Thr Ser Asn Ser Thr Asn Val 
            100                 105                 110         


Asn Ser Ser Ser Thr Asp Asn Thr Thr Leu Gly Glu Ile Lys Asn Cys 
        115                 120                 125             


Ser Phe Asp Ile Thr Thr Glu Ile Arg Asp Lys Thr Arg Lys Glu Tyr 
    130                 135                 140                 


Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asp Asn Ser Ser Asn 
145                 150                 155                 160 


Pro Asn Ser Ser Asn Thr Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr 
                165                 170                 175     


Cys Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His 
            180                 185                 190         


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr 
        195                 200                 205             


Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr 
    210                 215                 220                 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
225                 230                 235                 240 


Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn Leu Ala Asp Asn 
                245                 250                 255     


Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val Glu Ile Val Cys 
            260                 265                 270         


Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly 
        275                 280                 285             


Gln Thr Phe Tyr Ala Thr Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr 
    290                 295                 300                 


Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu Ala Val Asn Gln Val Lys 
305                 310                 315                 320 


Lys Lys Leu Lys Glu His Phe Pro His Lys Asn Ile Ser Phe Gln Ser 
                325                 330                 335     


Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly 
            340                 345                 350         


Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Asp Thr Ile 
        355                 360                 365             


Ser Asn Ala Thr Ile Met Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn 
    370                 375                 380                 


Met Trp Gln Glu Val Gly Lys Cys Ile Tyr Ala Pro Pro Ile Lys Gly 
385                 390                 395                 400 


Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly Leu Leu Leu Leu Arg Asp 
                405                 410                 415     


Gly Gly Asn Thr Thr Asn Asn Thr Glu Ile Phe Arg Pro Gly Gly Gly 
            420                 425                 430         


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
        435                 440                 445             


Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Cys Lys Arg Arg Val 
    450                 455                 460                 


Val Gly Arg Arg Arg Arg Arg Arg Ala Val Gly Ile Gly Ala Val Phe 
465                 470                 475                 480 


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met 
                485                 490                 495     


Thr Leu Thr Val Gln Ala Arg Asn Leu Leu Ser Gly Ile Val Gln Gln 
            500                 505                 510         


Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys 
        515                 520                 525             


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
    530                 535                 540                 


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
545                 550                 555                 560 


Gly Lys Leu Ile Cys Cys Thr Asn Val Pro Trp Asn Ser Ser Trp Ser 
                565                 570                 575     


Asn Arg Asn Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp 
            580                 585                 590         


Asp Lys Glu Ile Ser Asn Tyr Thr Gln Ile Ile Tyr Gly Leu Leu Glu 
        595                 600                 605             


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
    610                 615                 620                 


Asp 
625 


<210>  180
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  45_01dG5core-gp120 without signal sequence

<400>  180

Val Trp Lys Glu Ala Thr Ala Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Glu Thr Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp 
    50                  55                  60                  


Ile Ile Ser Leu Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Glu Asn 
145                 150                 155                 160 


Ile Lys Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Glu Thr Val 
                165                 170                 175     


Glu Ile Asn Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asp Ile Arg Gln Ala His Cys Asn Ile Ser Lys Ala Lys Trp Glu Asn 
        195                 200                 205             


Thr Leu Lys Gln Ile Ala Arg Lys Leu Arg Glu His Phe Lys Asn Glu 
    210                 215                 220                 


Thr Ile Ala Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Met 
225                 230                 235                 240 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln 
                245                 250                 255     


Leu Phe Asn Ser Thr Trp Thr Trp Asn Asp Thr Glu Val Val Asn Asn 
            260                 265                 270         


Thr Glu Lys Asn Ile Asn Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile 
        275                 280                 285             


Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile 
    290                 295                 300                 


Lys Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr 
305                 310                 315                 320 


Arg Asp Gly Gly Ser Ser Thr Asn Gly Thr Thr Glu Thr Phe Arg Pro 
                325                 330                 335     


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
            340                 345                 350         


Lys Val Val Lys Ile Glu Pro Leu 
        355                 360 


<210>  181
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  45_01dH1core-gp120 without signal sequence

<400>  181

Val Trp Lys Glu Ala Ser Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Asp Thr Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu 
        35                  40                  45              


Lys Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp 
    50                  55                  60                  


Ile Ile Ser Leu Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Ile Ser Phe Glu Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asp Lys Lys Phe Asn Gly Thr Gly Lys Cys Thr Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn 
145                 150                 155                 160 


Leu Thr Asp Asn Ala Lys Thr Leu Ile Val Gln Leu Asn Glu Thr Val 
                165                 170                 175     


Ala Ile Asn Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asn Ile Arg Gln Ala His Cys Asn Ile Ser Glu Thr Asp Trp Asn Asn 
        195                 200                 205             


Thr Leu Lys Gln Val Ala Arg Lys Leu Arg Glu Leu Phe Asn Lys Thr 
    210                 215                 220                 


Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Met His 
225                 230                 235                 240 


Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu 
                245                 250                 255     


Phe Asn Ser Thr Trp His Gly Asn Glu Thr Glu Glu Ser Ser Ile Thr 
            260                 265                 270         


Lys Asp Asn Lys Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Val 
        275                 280                 285             


Asn Arg Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Glu 
    290                 295                 300                 


Gly Leu Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
305                 310                 315                 320 


Asp Gly Gly Asn Ile Thr Asn Glu Thr Thr Thr Glu Thr Phe Arg Pro 
                325                 330                 335     


Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
            340                 345                 350         


Lys Val Val Lys Ile Glu Pro Leu 
        355                 360 


<210>  182
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c:BG505_DM-Sosip without signal sequence

<400>  182

Glu Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
1               5                   10                  15      


Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys 
            20                  25                  30          


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
        35                  40                  45              


Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
    50                  55                  60                  


Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp Val Ile Ser Ile 
65                  70                  75                  80  


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
                85                  90                  95      


Thr Leu Asn Cys Thr Asn Val Asn Val Thr Ser Asn Ser Thr Asn Val 
            100                 105                 110         


Asn Ser Ser Ser Thr Asp Asn Thr Thr Leu Gly Glu Ile Lys Asn Cys 
        115                 120                 125             


Ser Phe Asp Ile Thr Thr Glu Ile Arg Asp Lys Thr Arg Lys Glu Tyr 
    130                 135                 140                 


Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asp Asn Ser Ser Asn 
145                 150                 155                 160 


Pro Asn Ser Ser Asn Thr Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr 
                165                 170                 175     


Cys Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His 
            180                 185                 190         


Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr 
        195                 200                 205             


Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr 
    210                 215                 220                 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
225                 230                 235                 240 


Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn Leu Ser Asp Asn 
                245                 250                 255     


Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val Glu Ile Val Cys 
            260                 265                 270         


Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly 
        275                 280                 285             


Gln Thr Phe Tyr Ala Thr Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr 
    290                 295                 300                 


Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu Ala Val Asn Gln Val Lys 
305                 310                 315                 320 


Lys Lys Leu Lys Glu His Phe Pro His Lys Asn Ile Ser Phe Gln Ser 
                325                 330                 335     


Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly 
            340                 345                 350         


Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Asp Thr Ile 
        355                 360                 365             


Ser Asn Ala Thr Ile Met Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn 
    370                 375                 380                 


Met Trp Gln Glu Val Gly Lys Cys Ile Tyr Ala Pro Pro Ile Lys Gly 
385                 390                 395                 400 


Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly Leu Leu Leu Leu Arg Asp 
                405                 410                 415     


Gly Gly Asn Thr Ala Asn Asn Ala Glu Ile Phe Arg Pro Gly Gly Gly 
            420                 425                 430         


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
        435                 440                 445             


Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Cys Lys Arg Arg Val 
    450                 455                 460                 


Val Gly Arg Arg Arg Arg Arg Arg Ala Val Gly Ile Gly Ala Val Phe 
465                 470                 475                 480 


Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met 
                485                 490                 495     


Thr Leu Thr Val Gln Ala Arg Asn Leu Leu Ser Gly Ile Val Gln Gln 
            500                 505                 510         


Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys 
        515                 520                 525             


Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
    530                 535                 540                 


Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
545                 550                 555                 560 


Gly Lys Leu Ile Cys Cys Thr Asn Val Pro Trp Asn Ser Ser Trp Ser 
                565                 570                 575     


Asn Arg Asn Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp 
            580                 585                 590         


Asp Lys Glu Ile Ser Asn Tyr Thr Gln Ile Ile Tyr Gly Leu Leu Glu 
        595                 600                 605             


Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu 
    610                 615                 620                 


Asp 
625 


<210>  183
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hxb2core-gp120 without signal sequence

<400>  183

Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Asp Thr Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Val Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asp Met Val Glu Gln Met His Glu Asp 
    50                  55                  60                  


Ile Ile Ser Leu Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn 
145                 150                 155                 160 


Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Thr Ser Val 
                165                 170                 175     


Glu Ile Asn Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn 
        195                 200                 205             


Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly Asn Asn 
    210                 215                 220                 


Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
225                 230                 235                 240 


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr 
                245                 250                 255     


Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser Thr Glu Gly 
            260                 265                 270         


Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu Pro Cys Arg Ile 
        275                 280                 285             


Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys Ala Met Tyr Ala 
    290                 295                 300                 


Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu 
305                 310                 315                 320 


Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu Ser Glu Ile Phe 
                325                 330                 335     


Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
            340                 345                 350         


Lys Tyr Lys Val Val Lys Ile Glu Pro Leu 
        355                 360         


<210>  184
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QH0692core-gp120 without signal sequence

<400>  184

Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Glu Thr Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Gly Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp 
    50                  55                  60                  


Ile Ile Ser Leu Trp Asp Glu Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu Asn 
145                 150                 155                 160 


Phe Thr Asn Asn Ala Lys Thr Ile Ile Val His Leu Lys Lys Ser Val 
                165                 170                 175     


Glu Ile Asn Cys Thr Arg Pro Gly Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asp Ile Arg Gln Ala His Cys Asn Leu Ser Ser Val Gln Trp Asn Asp 
        195                 200                 205             


Thr Leu Lys Gln Ile Val Ile Lys Leu Gly Glu Gln Phe Gly Thr Asn 
    210                 215                 220                 


Lys Thr Ile Ala Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
225                 230                 235                 240 


Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr 
                245                 250                 255     


Gln Leu Phe Asn Ser Thr Trp Glu Phe His Gly Asn Trp Thr Arg Ser 
            260                 265                 270         


Asn Phe Thr Glu Ser Asn Ser Thr Thr Ile Thr Leu Pro Cys Arg Ile 
        275                 280                 285             


Lys Gln Ile Val Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala 
    290                 295                 300                 


Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu 
305                 310                 315                 320 


Leu Leu Thr Arg Asp Gly Gly Val Asn Gly Thr Arg Glu Thr Phe Arg 
                325                 330                 335     


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
            340                 345                 350         


Tyr Lys Val Val Lys Ile Glu Pro Leu 
        355                 360     


<210>  185
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of glVRC/NIH VRC01-class antibody

<400>  185

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  186
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of glVRC/NIH VRC01-class antibody

<400>  186

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  187
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of glVRC/NIH and of gl3BNC60 VRC01-class antibodies

<400>  187

Gln Gln Tyr Glu Phe 
1               5   


<210>  188
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of gll2A21, of gl3BNC60, and of glVRC-CH31 VRC01-class 
       antibodies

<400>  188

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  189
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of gll2A21, of gl3BNC60, and of glVRC-CH31 VRC01-class 
       antibodies

<400>  189

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  190
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of gll2A21 VRC01-class antibody

<400>  190

Ala Val Leu Glu Phe 
1               5   


<210>  191
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of glVRC-CH31 VRC01-class antibody

<400>  191

Gln Gln Tyr Glu Thr 
1               5   


<210>  192
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of glPGV04 VRC01-class antibody

<400>  192

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  193
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of glPGV04 VRC01-class antibody

<400>  193

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  194
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of glPGV04 VRC01-class antibody

<400>  194

Gln Gln Leu Glu Phe 
1               5   


<210>  195
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of glPGV19/20 VRC01-class antibody

<400>  195

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  196
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of glPGV19/20 VRC01-class antibody

<400>  196

Glu Val Ser Asn Arg Pro Ser 
1               5           


<210>  197
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of glPGV19/20 VRC01-class antibody

<400>  197

Ser Ser Tyr Glu Phe 
1               5   


<210>  198
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  198

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Lys Thr Gly Gly Pro Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  199
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  199

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Lys Thr Gly Gly Pro Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Phe Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  200
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  200

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  201
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  201

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Lys Thr Gly Gly Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  202
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  202

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ala Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  203
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  203
gccaccgtac gtttcagctc cagcttggtc                                        30


<210>  204
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  204

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser 
            


<210>  205
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  205

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Thr Asn Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  206
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  206

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Pro Leu Tyr Ser 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  207
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  207

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Gln Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  208
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  208

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  209
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  209

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Met 
            


<210>  210
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  210

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  211
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  211

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Pro Leu Tyr Ser 
            20                  25                  30          


Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  212
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  212

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asp Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Arg Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  213
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  213

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  214
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  214

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asp Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Met 
            


<210>  215
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  215

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  216
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  216

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  217
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  217

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Gly Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Cys Asn Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  218
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  218
gayattgtgm tsacmcarwc tmca                                              24


<210>  219
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  219

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser 
            


<210>  220
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  220

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Ile Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Trp Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  221
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  221

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  222
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  222

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Glu Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ala 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  223
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  223

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Thr Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  224
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain primer

<400>  224
ctcttcctcc tgtcagtaac tgaaggtgtc c                                      31


<210>  225
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  225

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Glu Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  226
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  226

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  227
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  227

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  228
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  228

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  229
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  229

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  230
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  230

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  231
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  231

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Asn Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Glu Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Val Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  232
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  232

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  233
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  233

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Ser Tyr Ser 
            20                  25                  30          


Asn Asn Glu Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  234
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  234

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Glu Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  235
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  235

Asp Ile Val Met Ser Gln Ser Pro Ser Pro Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Asn Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Glu Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  236
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  236

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Glu Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Val Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  237
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  237

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Asn Val Leu Tyr Ser 
            20                  25                  30          


Ser Asp Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Lys 
            


<210>  238
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  238

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Glu Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Thr Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  239
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain primer

<400>  239
tgaggagacg gtgaccaggg tgcc                                              24


<210>  240
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  240

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Asn Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Glu Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Val Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  241
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  241

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Leu Ser Leu Leu Asp Asn 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Phe Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Gln 
            


<210>  242
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  242

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Leu Ser Leu Leu Asp Asn 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Gln 
            


<210>  243
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  243

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Glu Thr 
            


<210>  244
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain primer

<400>  244
caggtgcagc tggtgcagtc tgg                                               23


<210>  245
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  245

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Trp Thr 
            


<210>  246
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  246

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro 
                85                  90                  95  


<210>  247
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  247

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr 
                85                  90          


<210>  248
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  248

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly 
                85                  90              


<210>  249
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  249

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Tyr Thr 
                85                  90              


<210>  250
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  250

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly 
                85                  90              


<210>  251
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  251

Asp Ile Val Met Ser Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly 
                85                  90              


<210>  252
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glVRC01 heavy chain

<400>  252

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr 
        115             


<210>  253
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P-p1f1 heavy chain

<400>  253

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr 
        115             


<210>  254
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P-p3b3 heavy chain

<400>  254

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Arg Gly Gly Thr Asn Tyr Cys Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Asn Ser Asp Tyr Thr Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr 
        115             


<210>  255
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01c-HuGL2 heavy chain

<400>  255

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Ile Ser Gly Asp Tyr Ser Gln Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr 
        115 


<210>  256
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glVRC01 light chain

<400>  256

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Leu Glu Ile 
            100         


<210>  257
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P-p1f1 light chain

<400>  257

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Glu Met Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105         


<210>  258
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P-p3b3 light chain

<400>  258

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Glu Thr Leu Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105         


<210>  259
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01c-HuGL2 light chain

<400>  259

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Arg Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105         


<210>  260
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hxb2 Core protein loop

<400>  260

Gly Gly Asn Ser Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly 
1               5                   10                  15      


<210>  261
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  45_01dH1 Core protein loop

<400>  261

Gly Gly Asn Ile Thr Asn Glu Thr Thr Thr Glu Thr Phe Arg Pro Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  262
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  93TH057 Core protein loop

<400>  262

Gly Gly Ala Asn Asn Thr Ser Thr Glu Thr Phe Arg Pro Gly Gly Gly 
1               5                   10                  15      


<210>  263
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q168a2 Core protein loop

<400>  263

Gly Gly Asn Asn Asn Ser Thr Asn Glu Thr Phe Arg Pro Gly Gly Gly 
1               5                   10                  15      


<210>  264
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Qh692 Core protein loop

<400>  264

Gly Gly Val Asn Gly Thr Arg Glu Thr Phe Arg Pro Gly Gly Gly 
1               5                   10                  15  


<210>  265
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  265
tgctgctgct ctgggttcca g                                                 21


<210>  266
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  266
attwtcagct tcctgctaat c                                                 21


<210>  267
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  267
ttttgctttt ctggattyca g                                                 21


<210>  268
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  268
tcgtgttkct stggttgtct g                                                 21


<210>  269
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  269
atggaatcac agrcycwggt                                                   20


<210>  270
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  270
tcttgttgct ctggttycca g                                                 21


<210>  271
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  271
cagttcctgg ggctcttgtt gttc                                              24


<210>  272
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain primer

<400>  272
ctcactagct cttctcctc                                                    19


<210>  273
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody VH1-2*02 domain

<400>  273

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asn Ser Asp Tyr Asn Trp Asp Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  274
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  426c core + GS linker + modified chicken C4b multimerization 
       domain

<400>  274

Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
1               5                   10                  15      


Ala Tyr Glu Lys Glu Cys His Asn Val Trp Ala Thr His Ala Cys Val 
            20                  25                  30          


Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu 
        35                  40                  45              


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp 
    50                  55                  60                  


Val Ile Ser Ile Trp Asp Gln Cys Leu Lys Pro Cys Val Lys Leu Thr 
65                  70                  75                  80  


Asn Thr Ser Thr Leu Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro 
                85                  90                  95      


Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys 
            100                 105                 110         


Asn Asn Lys Thr Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr 
        115                 120                 125             


Val Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu 
    130                 135                 140                 


Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn 
145                 150                 155                 160 


Leu Arg Asp Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val 
                165                 170                 175     


Glu Ile Val Cys Thr Arg Pro Asn Asn Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu 
        195                 200                 205             


Ala Val Asn Gln Val Lys Lys Lys Leu Lys Glu His Phe Pro His Lys 
    210                 215                 220                 


Asn Ile Ser Phe Gln Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr 
225                 230                 235                 240 


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly 
                245                 250                 255     


Leu Phe Asn Asp Thr Ile Ser Asn Ala Thr Ile Met Leu Pro Cys Arg 
            260                 265                 270         


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Ile Tyr 
        275                 280                 285             


Ala Pro Pro Ile Lys Gly Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly 
    290                 295                 300                 


Leu Leu Leu Leu Arg Asp Gly Gly Asp Thr Thr Asp Asn Thr Glu Ile 
305                 310                 315                 320 


Phe Arg Pro Ser Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu 
                325                 330                 335     


Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Ser Ser Lys Lys 
            340                 345                 350         


Gln Gly Asp Ala Asp Val Cys Gly Glu Val Ala Tyr Ile Gln Ser Val 
        355                 360                 365             


Val Ser Asp Cys His Val Pro Thr Ala Glu Leu Arg Thr Leu Leu Glu 
    370                 375                 380                 


Ile Arg Lys Leu Phe Leu Glu Ile Gln Lys Leu Lys Val Glu Leu Gln 
385                 390                 395                 400 


Gly Leu Ser Lys Glu 
                405 


<210>  275
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variable light chain

<400>  275

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Leu Ser Leu Leu Asp Asn 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Phe Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Gln 
            


