                         SEQUENCE LISTING

<110>  UNIVERSITY OF VIRGINIA PATENT FOUNDATION
       Zeichner, Steven L.
       Ganser-Pornillos, Barbie
       Pornillos, Owen
 
<120>  COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING VIRUS 
       INFECTION

<130>  3062/68 PCT

<150>  US 62/723,131
<151>  2018-08-27

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  1

Gln Tyr Arg Pro Glu Asn Gly Ser Tyr Ala Thr Asn Met Ala Leu Ala 
1               5                   10                  15      


Asn Ser Leu Phe Leu Met Asp Leu Asn Glu Arg Lys Gln Phe Arg Ala 
            20                  25                  30          


Met Ser Asp Asn Thr Gln Pro Glu Ser Ala Ser Val Trp Met Lys Ile 
        35                  40                  45              


Thr Gly Gly Ile Ser Ser Gly Lys Leu Asn Asp Gly Gln Asn Lys Thr 
    50                  55                  60                  


Thr Thr Asn Gln Phe Ile Asn Gln Leu Gly Gly Asp Ile Tyr Lys Phe 
65                  70                  75                  80  


His Ala Glu Gln Leu Gly Asp Phe Thr Leu Gly Ile Met Gly Gly Tyr 
                85                  90                  95      


Ala Asn Ala Lys Gly Lys Thr Ile Asn Tyr Thr Ser Asn Lys Ala Ala 
            100                 105                 110         


Arg Asn Thr Leu Asp Gly Tyr Ser Val Gly Val Tyr Gly Thr Trp Tyr 
        115                 120                 125             


Gln Asn Gly Glu Asn Ala Thr Gly Leu Phe Ala Glu Thr Trp Met Gln 
    130                 135                 140                 


Tyr Asn Trp Phe Asn Ala Ser Val Lys Gly Asp Gly Leu Glu Glu Glu 
145                 150                 155                 160 


Lys Tyr Asn Leu Asn Gly Leu Thr Ala Ser Ala Gly Gly Gly Tyr Asn 
                165                 170                 175     


Leu Asn Val His Thr Trp Thr Ser Pro Glu Gly Ile Thr Gly Glu Phe 
            180                 185                 190         


Trp Leu Gln Pro His Leu Gln Ala Val Trp Met Gly Val Thr Pro Asp 
        195                 200                 205             


Thr His Gln Glu Asp Asn Gly Thr Val Val Gln Gly Ala Gly Lys Asn 
    210                 215                 220                 


Asn Ile Gln Thr Lys Ala Gly Ile Arg Ala Ser Trp Lys Val Lys Ser 
225                 230                 235                 240 


Thr Leu Asp Lys Asp Thr Gly Arg Arg Phe Arg Pro Tyr Ile Glu Ala 
                245                 250                 255     


Asn Trp Ile His Asn Thr His Glu Phe Gly Val Lys Met Ser Asp Asp 
            260                 265                 270         


Ser Gln Leu Leu Ser Gly Ser Arg Asn Gln Gly Glu Ile Lys Thr Gly 
        275                 280                 285             


Ile Glu Gly Val Ile Thr Gln Asn Leu Ser Val Asn Gly Gly Val Ala 
    290                 295                 300                 


Tyr Gln Ala Gly Gly His Gly Ser Asn Ala Ile Ser Gly Ala Leu Gly 
305                 310                 315                 320 


Ile Lys Tyr Ser Phe 
                325 


<210>  2
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide sequence

<400>  2

Leu Asn Pro Thr Lys Glu Ser Ala Gly Asn Leu Thr Val Ser Asn Tyr 
1               5                   10                  15      


Thr Gly Thr Pro Gly Ser Val Ile Ser Leu Gly Gly Val Leu Glu Gly 
            20                  25                  30          


Asp Asn Ser Leu Thr Asp Arg Leu Val Val Lys Gly Asn Thr Ser Gly 
        35                  40                  45              


Gln Ser Asp Ile Val Tyr Val Asn Glu Asp Gly Ser Gly Gly Gln Thr 
    50                  55                  60                  


Arg Asp Gly Ile Asn Ile Ile Ser Val Glu Gly Asn Ser Asp Ala Glu 
65                  70                  75                  80  


Phe Ser Leu Lys Asn Arg Val Val Ala Gly Ala Tyr Asp Tyr Thr Leu 
                85                  90                  95      


Gln Lys Gly Asn Glu Ser Gly Thr Asp Asn Lys Gly Trp Tyr Leu Thr 
            100                 105                 110         


Ser His Leu Pro Thr Ser Asp Thr Arg 
        115                 120     


<210>  3
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  3

Gly Thr Ala Ser Ala Leu Ala Ala Ser Gln Leu Pro Gln Ala Thr Met 
1               5                   10                  15      


Pro Gly Lys Ser Met Val Ala Ile Ala Gly Ser Ser Tyr Gln Gly Gln 
            20                  25                  30          


Asn Gly Leu Ala Ile Gly Val Ser Arg Ile Ser Asp Asn Gly Lys Val 
        35                  40                  45              


Ile Ile Arg Leu Ser Gly Thr Thr Asn Ser Gln Gly Lys Thr Gly Val 
    50                  55                  60                  


Ala Ala Gly Val Gly Tyr Gln Trp 
65                  70          


<210>  4
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  4

Asn Val Ala Asn Gly Asp Ile Ser Ala Thr Ser Thr Asp Ala Ile Asn 
1               5                   10                  15      


Gly Ser Gln Leu Tyr Ala Val Ala Lys Gly Val Thr Asn Leu Ala Gly 
            20                  25                  30          


Gln Val Asn Asn Leu Glu Gly Lys Val Asn Lys Val Gly Lys Arg Ala 
        35                  40                  45              


Asp Ala 
    50  


<210>  5
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  5

Ala Ser Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile 
1               5                   10                  15      


Lys Asn Leu Ile Ala Ile Gly Ile Gly Ala Thr Leu Gly Ala Trp Leu 
            20                  25                  30          


Arg Trp Val Leu Gly Leu Lys Leu Asn Gly Ala Gly Trp Pro Trp Gly 
        35                  40                  45              


Thr Leu Thr Ala Asn Leu Val Gly Gly Tyr Leu Ile Gly Val Met Val 
    50                  55                  60                  


Ala Leu Ile Ala Ser His Pro Ser Trp Pro Ala Trp Ile Arg Leu Ala 
65                  70                  75                  80  


Ala Val Thr Gly Phe Leu Gly Gly Leu Thr Thr Phe Ser Thr Phe Ser 
                85                  90                  95      


Ala Glu Thr Val Asp Met Leu Cys Arg Gly Val Tyr Ala Thr Ala Ala 
            100                 105                 110         


Ala Tyr Ala Gly Ala Ser Leu Ala Gly Ser Leu Ala Met Thr Gly Leu 
        115                 120                 125             


Gly Leu Ala Thr Val Arg Leu Leu Leu 
    130                 135         


<210>  6
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  6

Lys Pro His Met Asn Leu Val Val Ile Gly His Val Asp His Gly Lys 
1               5                   10                  15      


Ser Thr Leu Val Gly His Leu Leu Ala Arg Leu Gly Tyr Ile Glu Trp 
            20                  25                  30          


Phe Lys Leu Thr Asn Leu Leu His Gln Ala Arg Ala Arg Gly Lys Gly 
        35                  40                  45              


Ser Phe Gly Phe Ala Trp Ile Leu Asp Lys Met Lys Glu Glu Arg Glu 
    50                  55                  60                  


Arg Gly Ile Thr Ile Asp Leu Thr Phe Met Lys Phe Glu Thr Lys Lys 
65                  70                  75                  80  


Tyr Val Phe Thr Ile Ile Asp Ala Pro Gly His Arg Asp Phe Val Lys 
                85                  90                  95      


Asn Met Ile Thr Gly Ala Ser Gln Ala Asp Ala Ala Ile Leu Val Val 
            100                 105                 110         


Ser Ala Arg Lys Gly Glu Phe Glu Ala Gly Met Ser Thr Glu Gly Gln 
        115                 120                 125             


Thr Arg Glu His Leu Leu Leu Ala Arg Thr Met Gly Ile Glu Gln Ile 
    130                 135                 140                 


Ile Val Ala Val Asn Lys Met Asp Ala Pro Asp Val Asn Tyr Asp Gln 
145                 150                 155                 160 


Lys Arg Tyr Glu Phe Val Val Ser Val Leu Lys Lys Phe Met Lys Gly 
                165                 170                 175     


Leu Gly Tyr Gln Val Asp Lys Ile Pro Phe Ile Pro Val Ser Ala Trp 
            180                 185                 190         


Lys Gly Asp Asn Leu Ile Glu Arg Ser Pro Asn Met Pro Trp Tyr Asn 
        195                 200                 205             


Gly Pro Thr Leu Val Glu Ala Leu Asp Gln Leu Gln Pro Pro Ala Lys 
    210                 215                 220                 


<210>  7
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  7

Ser Asp Pro Val Arg Gln Tyr Leu His Glu Ile Gly Glu Val Leu Glu 
1               5                   10                  15      


Leu Asp Lys Trp Ala Glu Leu Gly Ala Ala Ala Lys Val Glu Glu Gly 
            20                  25                  30          


Met Glu Ala Ile Lys Lys Leu Ser Glu Ala Thr Gly Leu Asp Gln Glu 
        35                  40                  45              


Leu Ile Arg Glu Val Val Arg Ala Lys Ile Leu Gly Thr Ala Ala Ile 
    50                  55                  60                  


Gln Lys Ile Pro Gly Leu Lys Glu Lys Pro Asp Pro Lys Thr Val Glu 
65                  70                  75                  80  


Glu Val Asp Gly Lys Leu Lys Ser Leu Pro Lys Glu Leu Lys Arg Tyr 
                85                  90                  95      


Leu His Ile Ala Arg Glu Gly Glu Ala Ala Arg Gln His Leu Ile Glu 
            100                 105                 110         


Ala Asn Leu Arg Leu Val Val Ser Ile Ala Lys Lys Tyr Thr Gly Arg 
        115                 120                 125             


Gly Leu Ser Phe Leu Asp Leu Ile Gln Glu Gly Asn Gln Gly Leu Ile 
    130                 135                 140                 


Arg Ala Val Glu Lys Phe Glu Tyr Lys Arg Gly Phe Ala Phe Ser Thr 
145                 150                 155                 160 


Tyr Ala Thr Trp Trp Ile Arg Gln Ala Ile Asn Arg Ala Ile Ala Asp 
                165                 170                 175     


Gln Ala Arg 
            


<210>  8
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized HA-tag encoding sequence

<400>  8
cctgtcttct tatccatacg atgtaccgga ttacgcggga agacgagtgt ta               52


<210>  9
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  9

Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
1               5                   10                  15      


Thr Asn Trp Leu Trp Tyr Ile Lys 
            20                  


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  10

Ile Phe Ile Ile Ile Val Gly Ser Leu Ile Gly Leu Arg 
1               5                   10              


<210>  11
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  11

Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
1               5                   10                  15      


Thr Asn Trp Leu Trp Tyr Ile Ser Gln Leu Pro Gln Ala Thr Met Pro 
            20                  25                  30          


Gly Lys Ser Met Val Ala Ile Ala Gly Ser Ser Tyr Gln Gly Gln Asn 
        35                  40                  45              


Gly Leu Ala Ile Gly Val Ser Arg Ile Ser Asp Asn Gly Lys Val Ile 
    50                  55                  60                  


Ile Arg Leu Ser Gly Thr Thr Asn Ser Gln Gly Lys Thr Gly Val Ala 
65                  70                  75                  80  


Ala Gly Val Gly Tyr Gln Trp 
                85          


<210>  12
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  12

Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
1               5                   10                  15      


Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val Ser Gln 
            20                  25                  30          


Leu Pro Gln Ala Thr Met Pro Gly Lys Ser Met Val Ala Ile Ala Gly 
        35                  40                  45              


Ser Ser Tyr Gln Gly Gln Asn Gly Leu Ala Ile Gly Val Ser Arg Ile 
    50                  55                  60                  


Ser Asp Asn Gly Lys Val Ile Ile Arg Leu Ser Gly Thr Thr Asn Ser 
65                  70                  75                  80  


Gln Gly Lys Thr Gly Val Ala Ala Gly Val Gly Tyr Gln Trp 
                85                  90                  


<210>  13
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  13

Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile 
1               5                   10                  15      


Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Ile Ile Val Gly Ser 
            20                  25                  30          


Leu Ile Gly Leu Arg Ser Gln Leu Pro Gln Ala Thr Met Pro Gly Lys 
        35                  40                  45              


Ser Met Val Ala Ile Ala Gly Ser Ser Tyr Gln Gly Gln Asn Gly Leu 
    50                  55                  60                  


Ala Ile Gly Val Ser Arg Ile Ser Asp Asn Gly Lys Val Ile Ile Arg 
65                  70                  75                  80  


Leu Ser Gly Thr Thr Asn Ser Gln Gly Lys Thr Gly Val Ala Ala Gly 
                85                  90                  95      


Val Gly Tyr Gln Trp 
            100     


<210>  14
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized peptide sequence

<400>  14

Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr 
1               5                   10                  15      


His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Val 
            20                  25                  30          


<210>  15
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized timerization domain

<400>  15

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


