                         SEQUENCE LISTING

<110>  King's College London
 
<120>  Engineered regulatory T cell

<130>  P115500PCT

<140>  PCT/GB2019/052422
<141>  2019-08-30

<150>  GB 1814203.4
<151>  2018-08-31

<160>  146   

<170>  PatentIn version 3.5

<210>  1
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 266 to 551 of interleukin-2 receptor beta  (IL2RB), 
       NP_000869.1 (IL2Rbeta endodomain)

<400>  1

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  2
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 265 to 459 of interleukin-7 receptor-alpha 
       (IL7R-alpha), NP_002176.2

<400>  2

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
65                  70                  75                  80  


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                85                  90                  95      


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            100                 105                 110         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        115                 120                 125             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    130                 135                 140                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
145                 150                 155                 160 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                165                 170                 175     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Gln 
        195 


<210>  3
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 292 to 521 of interleukin-9 receptor (IL9R), 
       NP_002177.2

<400>  3

Lys Leu Ser Pro Arg Val Lys Arg Ile Phe Tyr Gln Asn Val Pro Ser 
1               5                   10                  15      


Pro Ala Met Phe Phe Gln Pro Leu Tyr Ser Val His Asn Gly Asn Phe 
            20                  25                  30          


Gln Thr Trp Met Gly Ala His Gly Ala Gly Val Leu Leu Ser Gln Asp 
        35                  40                  45              


Cys Ala Gly Thr Pro Gln Gly Ala Leu Glu Pro Cys Val Gln Glu Ala 
    50                  55                  60                  


Thr Ala Leu Leu Thr Cys Gly Pro Ala Arg Pro Trp Lys Ser Val Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Gln Glu Gly Pro Gly Thr Arg Leu Pro Gly Asn Leu 
                85                  90                  95      


Ser Ser Glu Asp Val Leu Pro Ala Gly Cys Thr Glu Trp Arg Val Gln 
            100                 105                 110         


Thr Leu Ala Tyr Leu Pro Gln Glu Asp Trp Ala Pro Thr Ser Leu Thr 
        115                 120                 125             


Arg Pro Ala Pro Pro Asp Ser Glu Gly Ser Arg Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Asn Asn Asn Asn Tyr Cys Ala Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Trp His Leu Ser Ala Leu Pro Gly Asn Thr Gln Ser Ser Gly Pro Ile 
                165                 170                 175     


Pro Ala Leu Ala Cys Gly Leu Ser Cys Asp His Gln Gly Leu Glu Thr 
            180                 185                 190         


Gln Gln Gly Val Ala Trp Val Leu Ala Gly His Cys Gln Arg Pro Gly 
        195                 200                 205             


Leu His Glu Asp Leu Gln Gly Met Leu Leu Pro Ser Val Leu Ser Lys 
    210                 215                 220                 


Ala Arg Ser Trp Thr Phe 
225                 230 


<210>  4
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 257 to 825 of interleukin-4 receptor-alpha 
       (IL4R-alpha), NPJD00409.1

<400>  4

Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
1               5                   10                  15      


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
            20                  25                  30          


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
        35                  40                  45              


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
    50                  55                  60                  


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
65                  70                  75                  80  


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
                85                  90                  95      


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
            100                 105                 110         


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
        115                 120                 125             


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
    130                 135                 140                 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
145                 150                 155                 160 


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
                165                 170                 175     


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
            180                 185                 190         


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
        195                 200                 205             


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
    210                 215                 220                 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
225                 230                 235                 240 


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
                245                 250                 255     


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
            260                 265                 270         


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
        275                 280                 285             


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
    290                 295                 300                 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
305                 310                 315                 320 


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
                325                 330                 335     


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
            340                 345                 350         


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
        355                 360                 365             


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
    370                 375                 380                 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
385                 390                 395                 400 


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
                405                 410                 415     


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
            420                 425                 430         


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
        435                 440                 445             


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
    450                 455                 460                 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
465                 470                 475                 480 


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
                485                 490                 495     


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
            500                 505                 510         


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
        515                 520                 525             


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
    530                 535                 540                 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
545                 550                 555                 560 


Val Gly Pro Thr Tyr Met Arg Val Ser 
                565                 


<210>  5
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 461 to 897 of IL3RB, NP_000386.1

<400>  5

Arg Phe Cys Gly Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu 
1               5                   10                  15      


Lys Ile Pro Asn Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala 
            20                  25                  30          


Glu Leu Trp Pro Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro 
        35                  40                  45              


Pro His Gln Gly Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val 
    50                  55                  60                  


Phe Pro Val Gly Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu 
65                  70                  75                  80  


Asp Pro Lys His Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro 
                85                  90                  95      


Ala Ala Ser Asp Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly 
            100                 105                 110         


Pro Pro Ala Ala Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp 
        115                 120                 125             


Phe Asn Gly Pro Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp 
    130                 135                 140                 


Ile Leu Gly Gln Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser 
145                 150                 155                 160 


Pro Pro Pro Gly Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln 
                165                 170                 175     


Val Gln Leu Val Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val 
            180                 185                 190         


Glu Val Glu Arg Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu 
        195                 200                 205             


Glu Ser Gly Gly Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly 
    210                 215                 220                 


Gly Gln Asp Gln Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly 
225                 230                 235                 240 


Asp Thr Glu Asp Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp 
                245                 250                 255     


Leu Val Phe Thr Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro 
            260                 265                 270         


Ser Leu Gly Leu Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu 
        275                 280                 285             


Ala Ser Gly Pro Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu 
    290                 295                 300                 


Gly Tyr Val Glu Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro 
305                 310                 315                 320 


Arg Asn Asn Pro Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro 
                325                 330                 335     


Gly Glu Arg Pro Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly 
            340                 345                 350         


Leu Leu Val Leu Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu 
        355                 360                 365             


Gly Pro Gly Pro Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro 
    370                 375                 380                 


Gly Pro Glu Ile Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro 
385                 390                 395                 400 


Pro Gly Gln Ala Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala 
                405                 410                 415     


Leu Lys Gln Gln Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys 
            420                 425                 430         


Pro Gly Glu Val Cys 
        435         


<210>  6
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 314 to 502 of IL17RB, NP_061195.2

<400>  6

Arg His Glu Arg Ile Lys Lys Thr Ser Phe Ser Thr Thr Thr Leu Leu 
1               5                   10                  15      


Pro Pro Ile Lys Val Leu Val Val Tyr Pro Ser Glu Ile Cys Phe His 
            20                  25                  30          


His Thr Ile Cys Tyr Phe Thr Glu Phe Leu Gln Asn His Cys Arg Ser 
        35                  40                  45              


Glu Val Ile Leu Glu Lys Trp Gln Lys Lys Lys Ile Ala Glu Met Gly 
    50                  55                  60                  


Pro Val Gln Trp Leu Ala Thr Gln Lys Lys Ala Ala Asp Lys Val Val 
65                  70                  75                  80  


Phe Leu Leu Ser Asn Asp Val Asn Ser Val Cys Asp Gly Thr Cys Gly 
                85                  90                  95      


Lys Ser Glu Gly Ser Pro Ser Glu Asn Ser Gln Asp Leu Phe Pro Leu 
            100                 105                 110         


Ala Phe Asn Leu Phe Cys Ser Asp Leu Arg Ser Gln Ile His Leu His 
        115                 120                 125             


Lys Tyr Val Val Val Tyr Phe Arg Glu Ile Asp Thr Lys Asp Asp Tyr 
    130                 135                 140                 


Asn Ala Leu Ser Val Cys Pro Lys Tyr His Leu Met Lys Asp Ala Thr 
145                 150                 155                 160 


Ala Phe Cys Ala Glu Leu Leu His Val Lys Gln Gln Val Ser Ala Gly 
                165                 170                 175     


Lys Arg Ser Gln Ala Cys His Asp Gly Cys Cys Ser Leu 
            180                 185                 


<210>  7
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7R-alpha 2Y truncated

<400>  7

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
65                  70                  75                  80  


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
                85                  90      


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Phe or Leu

<400>  8

Tyr Xaa Xaa Xaa 
1               


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  9

Tyr Cys Thr Phe 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  10

Tyr Phe Phe Phe 
1               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  11

Tyr Leu Ser Leu 
1               


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  12

Tyr Leu Ser Leu Gln 
1               5   


<210>  13
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  13

Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln 
1               5                   10                  15      


Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro 
            20                  25                  30          


Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser 
        35                  40                  45              


Pro Leu Glu Val Leu Glu Arg Asp Lys 
    50                  55          


<210>  14
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  14

Asn Pro Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Asp Phe Ser 
1               5                   10                  15      


Gly His Thr His Pro Val Ala Thr Phe Gln Pro Ser Arg Pro Glu Ser 
            20                  25                  30          


Val Asn Asp Leu Phe Leu Cys Pro Gln Lys Glu Leu Thr 
        35                  40                  45  


<210>  15
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  15

Gly Tyr Ile Cys Leu Arg Asn Ser Leu Pro Lys Val Leu Asn Phe His 
1               5                   10                  15      


Asn Phe Leu Ala Trp Pro Phe Pro Asn Leu Pro Pro Leu Glu Ala Met 
            20                  25                  30          


Asp Met Val Glu Val Ile Tyr Ile Asn Arg 
        35                  40          


<210>  16
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  16

Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile Ser Val 
1               5                   10                  15      


Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr Val Ser 
            20                  25                  30          


Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu 
        35                  40          


<210>  17
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  17

Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe Lys Lys Pro Ser 
1               5                   10                  15      


Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu Thr Gln Asp Thr 
            20                  25                  30          


Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys 
        35                  40              


<210>  18
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  18

Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn Leu Ile Leu Ile 
1               5                   10                  15      


Tyr Gly Asn Glu Phe Asp Lys Arg Phe Phe Val Pro Ala Glu Lys Ile 
            20                  25                  30          


Val Ile Asn Phe Ile Thr Leu Asn Ile Ser Asp Asp Ser 
        35                  40                  45  


<210>  19
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  19

Arg Tyr Val Thr Lys Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln 
1               5                   10                  15      


Arg Val Leu Thr Phe Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu 
            20                  25                  30          


Ile Pro Val Phe Asp Leu Ser Gly Pro 
        35                  40      


<210>  20
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK2-binding motif

<400>  20

Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu 
1               5                   10                  15      


Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu 
            20                  25                  30          


Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn 
        35                  40              


<210>  21
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK2-binding motif

<400>  21

Tyr Trp Phe His Thr Pro Pro Ser Ile Pro Leu Gln Ile Glu Glu Tyr 
1               5                   10                  15      


Leu Lys Asp Pro Thr Gln Pro Ile Leu Glu Ala Leu Asp Lys Asp Ser 
            20                  25                  30          


Ser Pro Lys Asp Asp Val Trp Asp Ser Val Ser Ile Ile Ser Phe Pro 
        35                  40                  45              


Glu 
    


<210>  22
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK2-binding motif

<400>  22

Tyr Ala Phe Ser Pro Arg Asn Ser Leu Pro Gln His Leu Lys Glu Phe 
1               5                   10                  15      


Leu Gly His Pro His His Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu 
            20                  25                  30          


Ser Asp Glu Asn Asp Val Phe Asp Lys Leu Ser Val Ile Ala Glu Asp 
        35                  40                  45              


Ser Glu Ser 
    50      


<210>  23
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated IL2Rbeta endodomain - Y510

<400>  23

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
65                  70                  75                  80  


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
                85                  90                  


<210>  24
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated IL2Rbeta endodomain - Y510 & Y392

<400>  24

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Asp Ala Tyr Cys Thr Phe Pro Ser 
65                  70                  75                  80  


Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser 
                85                  90                  95      


Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met 
            100                 105                 110         


Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro 
        115                 120                 125             


Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro 
    130                 135                 140                 


Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala 
145                 150                 155                 160 


Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln 
                165                 170                 175     


Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala 
            180                 185                 190         


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200                 205             


<210>  25
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK3-binding motif

<400>  25

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile 
    50          


<210>  26
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK3-binding motif

<400>  26

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
    50                  55                  60                  


Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr 
65                  70                  75                  80  


Thr Leu Lys Pro Glu Thr 
                85      


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular signaling domain of human CD3 zeta chain

<400>  27

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  28
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 signaling domain

<400>  28

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  29
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27 signaling domain

<400>  29

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  30
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 signalling domain

<400>  30

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  31
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB signalling domain

<400>  31

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  32
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS signalling domain

<400>  32

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  33
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNFRSF25 signalling domain

<400>  33

Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala 
1               5                   10                  15      


Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu 
            20                  25                  30          


Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser 
        35                  40                  45              


Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly 
    50                  55                  60                  


Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp 
65                  70                  75                  80  


Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu 
                85                  90                  95      


Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly 
            100                 105                 110         


Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys 
        115                 120                 125             


Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val 
    130                 135                 140                 


Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys 
145                 150                 155                 160 


Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala 
                165                 170                 175     


Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg 
            180                 185                 190         


Leu Gln Arg Gly Pro 
        195         


<210>  34
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu 
            180                 185                 190         


Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu Gly 
                245     


<210>  35
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain, CD28 transmembrane

<400>  35

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  36
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain, CD28 hinge and transmembrane sequence

<400>  36

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val 
65      


<210>  37
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane and intracellular portion of human CD28

<400>  37

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  38
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain, CD28

<400>  38

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-Myc tag

<400>  39

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  40
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge/transmembrane domain with integrated c-Myc tag

<400>  40

Ile Glu Val Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Asp Asn 
1               5                   10                  15      


Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys 
            20                  25                  30          


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
        35                  40                  45              


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    50                  55                  60                  


Phe Ile Ile Phe Trp Val 
65                  70  


<210>  41
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  42
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor (CAR) containing HLA-A2 scFV, c-Myc 
       tag, CD28, IL2RB-Y510, CD3 zeta endodomain

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Asp Asn Glu Lys 
        275                 280                 285             


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
    290                 295                 300                 


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Asn Cys Arg 
    370                 375                 380                 


Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp 
385                 390                 395                 400 


Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val 
                405                 410                 415     


Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly 
            420                 425                 430         


Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys 
        435                 440                 445             


Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
    450                 455                 460                 


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Arg Val Lys Phe Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                485                 490                 495     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            500                 505                 510         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        515                 520                 525             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    530                 535                 540                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
545                 550                 555                 560 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                565                 570                 575     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu Thr Arg Gly Gly 
            580                 585                 590         


Gly Ala Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
        595                 600                 605             


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
    610                 615                 620                 


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
625                 630                 635                 640 


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
                645                 650                 655     


Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
            660                 665                 670         


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
        675                 680                 685             


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
    690                 695                 700                 


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
705                 710                 715                 720 


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
                725                 730                 735     


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
            740                 745                 750         


Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu 
        755                 760                 765             


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
    770                 775                 780                 


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
785                 790                 795                 800 


Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
                805                 810                 815     


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
            820                 825                 830         


Tyr Lys 
        


<210>  43
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR containing HLA-A2 scFV, c-Myc tag, CD28, IL2RG-T52, 
       IL2RB-Y510, CD3 zeta endodomain

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Asp Asn Glu Lys 
        275                 280                 285             


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
    290                 295                 300                 


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Glu Arg Thr 
    370                 375                 380                 


Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu 
385                 390                 395                 400 


Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala 
                405                 410                 415     


Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu 
            420                 425                 430         


Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys 
        435                 440                 445             


Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His 
    450                 455                 460                 


Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser 
465                 470                 475                 480 


Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu 
                485                 490                 495     


Glu Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr 
            500                 505                 510         


Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Arg 
        515                 520                 525             


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
    530                 535                 540                 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
545                 550                 555                 560 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
                565                 570                 575     


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
            580                 585                 590         


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
        595                 600                 605             


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
    610                 615                 620                 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635                 


<210>  44
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR containing HLA-A2 scFV, c-Myc tag, CD28, IL2RG-T52, IL7RA-2Y,
       CD3 zeta endodomain

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Asp Asn Glu Lys 
        275                 280                 285             


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
    290                 295                 300                 


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Glu Arg Thr 
    370                 375                 380                 


Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu 
385                 390                 395                 400 


Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala 
                405                 410                 415     


Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu 
            420                 425                 430         


Ile Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His 
        435                 440                 445             


Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn 
    450                 455                 460                 


Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val 
465                 470                 475                 480 


Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr 
                485                 490                 495     


Phe Pro Gln Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu 
            500                 505                 510         


Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Arg Val Lys Phe 
        515                 520                 525             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    530                 535                 540                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
545                 550                 555                 560 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                565                 570                 575     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            580                 585                 590         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        595                 600                 605             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    610                 615                 620                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
625                 630                 635                 640 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
                645                 650                 655     


Gly 
    


<210>  45
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  illustrative endodomain sequence comprising CD28, IL2RG-T52, 
       IL2RB-Y510, CD3 zeta signalling domains

<400>  45

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Glu Arg Thr Met Pro Arg Ile 
        35                  40                  45              


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
    50                  55                  60                  


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Asn Cys Arg 
                85                  90                  95      


Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp 
            100                 105                 110         


Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val 
        115                 120                 125             


Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly 
    130                 135                 140                 


Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys 
145                 150                 155                 160 


Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
                165                 170                 175     


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Arg Val Lys Phe Ser 
            180                 185                 190         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        195                 200                 205             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    210                 215                 220                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
225                 230                 235                 240 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                245                 250                 255     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            260                 265                 270         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        275                 280                 285             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    290                 295                 


<210>  46
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide - cleavage domain

<400>  46

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  47
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A peptide - cleavage domain

<400>  47

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  48
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A peptide - cleavage domain

<400>  48

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  49
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A peptide - cleavage domain

<400>  49

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  50
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin site - cleavage domain


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  50

Arg Xaa Xaa Arg 
1               


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin site - cleavage domain

<400>  51

Arg Arg Lys Arg 
1               


<210>  52
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT3 association motif


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Tyr Xaa Xaa Gln 
1               


<210>  53
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  illustrative endodomain sequence comprising CD28, IL2RG-T52, 
       IL7RA-2Y, CD3 zeta signalling domains

<400>  53

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Glu Arg Thr Met Pro Arg Ile 
        35                  40                  45              


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
    50                  55                  60                  


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Lys Lys Arg 
                85                  90                  95      


Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu 
            100                 105                 110         


Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn 
        115                 120                 125             


Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln 
    130                 135                 140                 


Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
145                 150                 155                 160 


Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr 
                165                 170                 175     


Met Ser Ser Phe Tyr Gln Asn Gln Arg Val Lys Phe Ser Arg Ser Ala 
            180                 185                 190         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        195                 200                 205             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    210                 215                 220                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
225                 230                 235                 240 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                245                 250                 255     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            260                 265                 270         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        275                 280                 285             


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
    290                 295                 300                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
305                 310                 315         


<210>  54
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy domain

<400>  54

Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr Gly 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Ala 
        35                  40                  45              


Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val 
        115                 120 


<210>  55
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy domain

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr 
        115         


<210>  56
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy domain

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr 
        115         


<210>  57
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy domain

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr 
        115         


<210>  58
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  58

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105             


<210>  59
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  59

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  60
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  60

Asp Ile Val Leu Met Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Arg Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  61

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  62
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  62

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Glu Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Glu Thr His Leu Asp Ser Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  63
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  63

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  64
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  64

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ser 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  65

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  66
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  66

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Thr Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asp Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  67
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  67

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  68
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  68

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  69

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Thr Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  70
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  70

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Thr Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  71
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  71

Asp Val Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Gly Ile Ser Asn Tyr 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  72
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  72

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Arg Gly Ser Asn Tyr Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Leu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  73
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
            100                 105                 110         


Trp Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile 
145                 150                 155                 160 


Ser His Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn 
    210                 215                 220                 


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235             


<210>  74
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Met Gln Ser Pro Ser Phe 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


His Gly Ile Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Tyr Pro Pro Thr Phe Gly Arg Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg 
    


<210>  75
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  75

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  76
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Glu Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Glu Thr His Leu Asp Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Thr Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  77
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Asn Leu Pro Ile Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  78
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Asn Leu Pro Ser Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  79
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  79

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asn Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  80
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  80

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Thr Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser 
        195                 200                 205             


Ile Asp Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  81
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  81

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  82
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  82

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser 
145                 150                 155                 160 


Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  83
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg 
                165                 170                 175     


Ala Pro Thr Leu Leu Ile Phe Ala Ala Ser Asn Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
    210                 215                 220                 


Asp Ser Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  84
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  84

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg 
                165                 170                 175     


Ala Pro Thr Leu Leu Ile Tyr Lys Ala Ser Asn Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Ser Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  85
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  85

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Phe 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


His Gly Ile Ser Asn Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  86
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Tyr Val Gly Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Arg Gly Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Gly Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    210                 215                 220                 


Asp Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
225                 230                 235                 240 


<210>  87
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain, CD8alpha transmembrane

<400>  87

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  88
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha hinge domain and CD28 transmembrane domain

<400>  88

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
        35                  40                  45              


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    50                  55                  60                  


Val Ala Phe Ile Ile Phe Trp Val 
65                  70          


<210>  89
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge domain and CD8alpha transmembrane domain

<400>  89

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        35                  40                  45              


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
    50                  55                  60  


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL heavy chain variable region (VH) complementarity determining 
       region (CDR), GL VH CDR1

<400>  90

Asp Tyr Gly Met His 
1               5   


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL VH CDR2

<400>  91

Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL VH CDR3

<400>  92

Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VH CDR1

<400>  93

Asp Tyr Gly Met His 
1               5   


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VH CDR2

<400>  94

Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VH CDR3

<400>  95

Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
1               5                   10                  


<210>  96
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VH CDR1

<400>  96

Asp Tyr Gly Met His 
1               5   


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VH CDR2

<400>  97

Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VH CDR3

<400>  98

Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VH CDR1

<400>  99

Asp Tyr Gly Met His 
1               5   


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VH CDR2

<400>  100

Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VH CDR3

<400>  101

Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL light chain variable region (VL) CDR1

<400>  102

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL VL CDR2

<400>  103

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL VL CDR3

<400>  104

Gln Gln Tyr Asp Asn Leu Pro Pro Thr 
1               5                   


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VL CDR1

<400>  105

Gln Ser Ser Leu Asp Ile Ser His Tyr Leu Asn 
1               5                   10      


<210>  106
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VL CDR2

<400>  106

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VL CDR3

<400>  107

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VL CDR1

<400>  108

Arg Ala Ser His Gly Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VL CDR2

<400>  109

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  110
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VL CDR3

<400>  110

Gln Gln Tyr Asp Ser Tyr Pro Pro Thr 
1               5                   


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VL CDR1

<400>  111

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VL CDR2

<400>  112

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VL CDR3

<400>  113

Gln Gln Tyr Ser Ser Phe Pro Leu Thr 
1               5                   


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 VL CDR1

<400>  114

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 VL CDR2

<400>  115

Asp Glu Thr His Leu Asp Ser 
1               5           


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 VL CDR3

<400>  116

Gln Gln Tyr Asp Ser Leu Pro Pro Thr 
1               5                   


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E7 VL CDR1

<400>  117

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E7 VL CDR2

<400>  118

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E7 VL CDR3

<400>  119

Gln Gln Tyr Asp Asn Leu Pro Ile Thr 
1               5                   


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H10 VL CDR1

<400>  120

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  121
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H10 VL CDR2

<400>  121

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H10 VL CDR3

<400>  122

Gln Gln Tyr Asp Asn Leu Pro Ser Thr 
1               5                   


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B8 VL CDR1

<400>  123

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B8 VL CDR2

<400>  124

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B8 VL CDR3

<400>  125

Gln Gln Tyr Asn Thr Tyr Pro Leu Thr 
1               5                   


<210>  126
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D2 VL CDR1

<400>  126

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D2 VL CDR2

<400>  127

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  128
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D2 VL CDR3

<400>  128

Gln Gln Tyr His Thr Tyr Pro Leu Thr 
1               5                   


<210>  129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B10 VL CDR1

<400>  129

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B10 VL CDR2

<400>  130

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B10 VL CDR3

<400>  131

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A9 VL CDR1

<400>  132

Arg Thr Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A9 VL CDR2

<400>  133

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A9 VL CDR3

<400>  134

Gln Gln Phe Asn Asn Tyr Pro Leu Thr 
1               5                   


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B12 VL CDR1

<400>  135

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B12 VL CDR2

<400>  136

Ala Ala Ser Asn Leu Gln Ser 
1               5           


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B12 VL CDR3

<400>  137

Leu Gln Asp Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D4 VL CDR1

<400>  138

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D4 VL CDR2

<400>  139

Lys Ala Ser Asn Leu Gln Ser 
1               5           


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D4 VL CDR3

<400>  140

Gln Gln Tyr Ser Asn Tyr Pro Leu Thr 
1               5                   


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D4 VL CDR1

<400>  141

Arg Ala Ser His Gly Ile Ser Asn Tyr Phe Ala 
1               5                   10      


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D4 VL CDR2

<400>  142

Ala Thr Ser Thr Leu Gln Ser 
1               5           


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D4 VL CDR3

<400>  143

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3 VL CDR1

<400>  144

Arg Ala Ser Arg Gly Ser Asn Tyr Leu Ala 
1               5                   10  


<210>  145
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3 VL CDR2

<400>  145

Ala Thr Ser Thr Leu Gln Ser 
1               5           


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3 VL CDR3

<400>  146

Gln Gln Tyr Asp Ser Tyr Pro Pro Thr 
1               5                   


