                         SEQUENCE LISTING

<110>  ɽҽҩ޹˾
 
<120>  PD-1-VEGFA˫ܿ塢ҩＰ;

<130>  IEC190067PCT

<150>  201811002548.4
<151>  2018-08-30

<160>  26    

<170>  PatentIn version 3.2

<210>  1
<211>  171
<212>  PRT
<213>  Artificial

<220>
<223>  VEGFA-Hisİ

<400>  1

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
        115                 120                 125             


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
    130                 135                 140                 


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
145                 150                 155                 160 


Asp Lys Pro Arg Arg His His His His His His 
                165                 170     


<210>  2
<211>  513
<212>  DNA
<213>  Artificial

<220>
<223>  VEGFA-Hisĺ

<400>  2
gcacccatgg ccgagggcgg cggccagaac caccacgagg tggtgaagtt catggacgtg     60

taccagagaa gctactgcca ccccatcgag accctggtgg acatcttcca ggagtacccc    120

gacgagatcg agtacatctt caagcccagc tgcgtgcccc tgatgagatg cggcggctgc    180

tgcaacgacg agggcctgga gtgcgtgccc accgaggaga gcaacatcac catgcagatc    240

atgagaatca agccccacca gggccagcac atcggcgaga tgagcttcct gcagcacaac    300

aagtgcgagt gcagacccaa gaaggacaga gccagacagg agaacccctg cggcccctgc    360

agcgagagaa gaaagcacct gttcgtgcag gacccccaga cctgcaagtg cagctgcaag    420

aacaccgaca gcagatgcaa ggccagacag ctggagctga acgagagaac ctgcagatgc    480

gacaagccca gaagacatca tcaccatcac cac                                 513


<210>  3
<211>  998
<212>  PRT
<213>  Artificial

<220>
<223>  ںϵVEGFR2- hFcİ

<400>  3

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ser Arg Glu Asn 
        755                 760                 765             


Leu Tyr Phe Gln Gly Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    770                 775                 780                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
785                 790                 795                 800 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                805                 810                 815     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            820                 825                 830         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        835                 840                 845             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    850                 855                 860                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
865                 870                 875                 880 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                885                 890                 895     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            900                 905                 910         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        915                 920                 925             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    930                 935                 940                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
945                 950                 955                 960 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                965                 970                 975     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            980                 985                 990         


Ser Leu Ser Pro Gly Lys 
        995             


<210>  4
<211>  2997
<212>  DNA
<213>  Artificial

<220>
<223>  ںϵVEGFR2- hFcĺ

<400>  4
atgcagagca aggtgctgct ggccgtcgcc ctgtggctct gcgtggagac ccgggccgcc     60

tctgtgggtt tgcctagtgt ttctcttgat ctgcccaggc tcagcataca aaaagacata    120

cttacaatta aggctaatac aactcttcaa attacttgca ggggacagag ggacttggac    180

tggctttggc ccaataatca gagtggcagt gagcaaaggg tggaggtgac tgagtgcagc    240

gatggcctct tctgtaagac actcacaatt ccaaaagtga tcggaaatga cactggagcc    300

tacaagtgct tctaccggga aactgacttg gcctcggtca tttatgtcta tgttcaagat    360

tacagatctc catttattgc ttctgttagt gaccaacatg gagtcgtgta cattactgag    420

aacaaaaaca aaactgtggt gattccatgt ctcgggtcca tttcaaatct caacgtgtca    480

ctttgtgcaa gatacccaga aaagagattt gttcctgatg gtaacagaat ttcctgggac    540

agcaagaagg gctttactat tcccagctac atgatcagct atgctggcat ggtcttctgt    600

gaagcaaaaa ttaatgatga aagttaccag tctattatgt acatagttgt cgttgtaggg    660

tataggattt atgatgtggt tctgagtccg tctcatggaa ttgaactatc tgttggagaa    720

aagcttgtct taaattgtac agcaagaact gaactaaatg tggggattga cttcaactgg    780

gaataccctt cttcgaagca tcagcataag aaacttgtaa accgagacct aaaaacccag    840

tctgggagtg agatgaagaa atttttgagc accttaacta tagatggtgt aacccggagt    900

gaccaaggat tgtacacctg tgcagcatcc agtgggctga tgaccaagaa gaacagcaca    960

tttgtcaggg tccatgaaaa accttttgtt gcttttggaa gtggcatgga atctctggtg   1020

gaagccacgg tgggggagcg tgtcagaatc cctgcgaagt accttggtta cccaccccca   1080

gaaataaaat ggtataaaaa tggaataccc cttgagtcca atcacacaat taaagcgggg   1140

catgtactga cgattatgga agtgagtgaa agagacacag gaaattacac tgtcatcctt   1200

accaatccca tttcaaagga gaagcagagc catgtggtct ctctggttgt gtatgtccca   1260

ccccagattg gtgagaaatc tctaatctct cctgtggatt cctaccagta cggcaccact   1320

caaacgctga catgtacggt ctatgccatt cctcccccgc atcacatcca ctggtattgg   1380

cagttggagg aagagtgcgc caacgagccc agccaagctg tctcagtgac aaacccatac   1440

ccttgtgaag aatggagaag tgtggaggac ttccagggag gaaataaaat tgaagttaat   1500

aaaaatcaat ttgctctaat tgaaggaaaa aacaaaactg taagtaccct tgttatccaa   1560

gcggcaaatg tgtcagcttt gtacaaatgt gaagcggtca acaaagtcgg gagaggagag   1620

agggtgatct ccttccacgt gaccaggggt cctgaaatta ctttgcaacc tgacatgcag   1680

cccactgagc aggagagcgt gtctttgtgg tgcactgcag acagatctac gtttgagaac   1740

ctcacatggt acaagcttgg cccacagcct ctgccaatcc atgtgggaga gttgcccaca   1800

cctgtttgca agaacttgga tactctttgg aaattgaatg ccaccatgtt ctctaatagc   1860

acaaatgaca ttttgatcat ggagcttaag aatgcatcct tgcaggacca aggagactat   1920

gtctgccttg ctcaagacag gaagaccaag aaaagacatt gcgtggtcag gcagctcaca   1980

gtcctagagc gtgtggcacc cacgatcaca ggaaacctgg agaatcagac gacaagtatt   2040

ggggaaagca tcgaagtctc atgcacggca tctgggaatc cccctccaca gatcatgtgg   2100

tttaaagata atgagaccct tgtagaagac tcaggcattg tattgaagga tgggaaccgg   2160

aacctcacta tccgcagagt gaggaaggag gacgaaggcc tctacacctg ccaggcatgc   2220

agtgttcttg gctgtgcaaa agtggaggca tttttcataa tagaaggtgc ccaggaaaag   2280

acgaacttgg aatctagaga aaacctgtat tttcagggca ctcacacatg cccaccgtgc   2340

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac   2400

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa   2460

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca   2520

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg   2580

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca   2640

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac   2700

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc   2760

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac   2820

aactacaaga ccacgcctcc cgtgttggac tccgacggct ccttcttcct ctacagcaag   2880

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat   2940

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctcccgg gaaatga      2997


<210>  5
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Bevacizumabɱİ

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  6
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  Bevacizumabɱĺ

<400>  6
gaggtgcagc tggtcgagtc cggggggggg ctggtgcagc caggcgggtc tctgaggctg     60

agttgcgccg cttcagggta caccttcaca aactatggaa tgaattgggt gcgccaggca    120

ccaggaaagg gactggagtg ggtcggctgg atcaacactt acaccgggga acctacctat    180

gcagccgact ttaagcggcg gttcaccttc agcctggata caagcaaatc cactgcctac    240

ctgcagatga acagcctgcg agctgaggac accgcagtct actattgtgc taaatatccc    300

cactactatg ggagcagcca ttggtatttt gacgtgtggg ggcaggggac tctggtgaca    360

gtgagcagc                                                            369


<210>  7
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Bevacizumabɱİ

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  8
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Bevacizumabɱĺ

<400>  8
gatattcaga tgactcagag cccctcctcc ctgtccgcct ctgtgggcga cagggtcacc     60

atcacatgca gtgcttcaca ggatatttcc aactacctga attggtatca gcagaagcca    120

ggaaaagcac ccaaggtgct gatctacttc actagctccc tgcactcagg agtgccaagc    180

cggttcagcg gatccggatc tggaaccgac tttactctga ccatttctag tctgcagcct    240

gaggatttcg ctacatacta ttgccagcag tattctaccg tgccatggac atttggccag    300

gggactaaag tcgagatcaa g                                              321


<210>  9
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Դ14C12H1L1ɱİ

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  10
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Դ14C12H1L1ɱĺ

<400>  10
gaagtgcagc tggtcgagtc tgggggaggg ctggtgcagc ccggcgggtc actgcgactg     60

agctgcgcag cttccggatt cgcctttagc tcctacgaca tgtcctgggt gcgacaggca    120

ccaggaaagg gactggattg ggtcgctact atctcaggag gcgggagata cacctactat    180

cctgacagcg tcaagggccg gttcacaatc tctagagata acagtaagaa caatctgtat    240

ctgcagatga acagcctgag ggctgaggac accgcactgt actattgtgc caaccgctac    300

ggggaagcat ggtttgccta ttgggggcag ggaaccctgg tgacagtctc tagt          354


<210>  11
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Դ14C12H1L1ɱİ

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Met Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  12
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Դ14C12H1L1ɱĺ

<400>  12
gacattcaga tgactcagag cccctcctcc atgtccgcct ctgtgggcga cagggtcacc     60

ttcacatgcc gcgctagtca ggatatcaac acctacctga gctggtttca gcagaagcca    120

gggaaaagcc ccaagacact gatctaccgg gctaatagac tggtgtctgg agtcccaagt    180

cggttcagtg gctcagggag cggacaggac tacactctga ccatcagctc cctgcagcct    240

gaggacatgg caacctacta ttgcctgcag tatgatgagt tcccactgac ctttggcgcc    300

gggacaaaac tggagctgaa g                                              321


<210>  13
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Linker 1İ

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  14
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  LinkerɵԪ

<400>  14

Gly Gly Gly Gly Ser 
1               5   


<210>  15
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  BevacizumabHCDR1

<400>  15

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  BevacizumabHCDR2

<400>  16

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  17
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  BevacizumabHCDR3

<400>  17

Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
1               5                   10                  15      


<210>  18
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  BevacizumabLCDR1

<400>  18

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  19
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  BevacizumabLCDR2

<400>  19

Phe Thr Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  BevacizumabLCDR3

<400>  20

Gln Gln Tyr Ser Thr Val Pro Trp Thr 
1               5                   


<210>  21
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1L1HCDR1

<400>  21

Gly Phe Ala Phe Ser Ser Tyr Asp 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1L1HCDR2

<400>  22

Ile Ser Gly Gly Gly Arg Tyr Thr 
1               5               


<210>  23
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1L1HCDR3

<400>  23

Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  24
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1L1LCDR1

<400>  24

Gln Asp Ile Asn Thr Tyr 
1               5       


<210>  25
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1L1LCDR2

<400>  25

Arg Ala Asn 
1           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1L1LCDR3

<400>  26

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


