                         SEQUENCE LISTING

<110>  Nanjing Legend Biotech Co., Ltd.
 
<120>  Anti-Mesothelin Chimeric Antigen Receptor (CAR) Constructs and 
       Uses Thereof

<130>  689296.13CN1

<160>  471   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126-VH CDR1

<400>  1

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126-VL CDR1

<400>  2

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58116-VH CDR1

<400>  3

Gly Tyr Thr Phe Thr Glu Tyr Thr Met Asn 
1               5                   10  


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58116-VL CDR1

<400>  4

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58117-VH CDR1

<400>  5

Phe Tyr Thr Phe Thr Ala Tyr Ser Met His 
1               5                   10  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58117-VL CDR1

<400>  6

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met Asn 
1               5                   10                  15  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58127-VH CDR1

<400>  7

Gly Tyr Thr Phe Thr Asp Tyr Glu Ile His 
1               5                   10  


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58127-VL CDR1

<400>  8

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58143-VH CDR1

<400>  9

Gly Tyr Thr Phe Thr Asp Tyr Glu Met His 
1               5                   10  


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58143-VL CDR1

<400>  10

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58159-VH CDR1

<400>  11

Gly Tyr Thr Ile Thr Asn Tyr Trp Leu Gly 
1               5                   10  


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58159-VL CDR1

<400>  12

Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58115-VH CDR1

<400>  13

Gly Tyr Thr Phe Thr Glu Tyr Thr Met Asn 
1               5                   10  


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58115-VL CDR1

<400>  14

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58123-VH CDR1

<400>  15

Gly Phe Ser Leu Ser Arg Tyr Ser Val His 
1               5                   10  


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58123-VL CDR1

<400>  16

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58145-VH CDR1

<400>  17

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58145-VL CDR1

<400>  18

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489-VH CDR1

<400>  19

Gly Phe Asn Leu Tyr Tyr Tyr Ser Ile His 
1               5                   10  


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489-VL CDR1

<400>  20

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51491-VH CDR1

<400>  21

Gly Phe Asn Leu Tyr Ser Tyr Ser Met His 
1               5                   10  


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51491-VL CDR1

<400>  22

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110-VH CDR1

<400>  23

Gly Phe Asn Ile Tyr Tyr Ser Ser Met His 
1               5                   10  


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110-VL CDR1

<400>  24

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156-VH CDR1

<400>  25

Gly Phe Asn Ile Tyr Ser Ser Ser Ile His 
1               5                   10  


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156-VL CDR1

<400>  26

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189-VH CDR1

<400>  27

Gly Phe Asn Leu Ser Tyr Ser Ser Ile His 
1               5                   10  


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189-VL CDR1

<400>  28

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674-VH CDR1

<400>  29

Gly Phe Asn Leu Tyr Ser Tyr Tyr Met His 
1               5                   10  


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674-VL CDR1

<400>  30

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66073 CDR1

<400>  31

Lys Tyr Ser Ser Leu Tyr Cys Met Ala 
1               5                   


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66439 CDR1

<400>  32

Gly Phe Thr Ser Ser Asp Cys Asp Met Asp 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65955 CDR1

<400>  33

Gly Asp Arg Val Ser Thr Gly Cys Met Gly 
1               5                   10  


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233 CDR1

<400>  34

Glu Phe Thr Tyr Ser Met Gly 
1               5           


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65926 CDR1

<400>  35

Gly Asn Leu Tyr Asn Asn Met Cys Met Gly 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66159 CDR1

<400>  36

Gly Asn Val Tyr Asn Asn Met Cys Met Gly 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66416 CDR1

<400>  37

Gly Asn Leu Tyr Asn Asn Met Cys Met Gly 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65850 CDR1

<400>  38

Gly Phe Ser Tyr Ser Asn Ile Cys Met Gly 
1               5                   10  


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65183 CDR1

<400>  39

Asn Gly Tyr Tyr Asn Arg Arg Tyr Cys Met Ala 
1               5                   10      


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65062 CDR1

<400>  40

Gly Val Ser Val Val Asn Phe Ala Met Arg 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65065 CDR1

<400>  41

Gly Tyr Ser Tyr Cys Arg Ser Thr Met Arg 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65556 CDR1

<400>  42

Gly Tyr Asn Ala Ser Ile Cys Arg Met Ser 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65069 CDR1

<400>  43

Gly Asp Thr Gly Tyr Gln Pro Thr Met Arg 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65691 CDR1

<400>  44

Gly Tyr Thr Asp Tyr Arg Leu Val Leu Arg 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65064 CDR1

<400>  45

Gly Asp Thr Val Gln Thr Asn Cys Met Ala 
1               5                   10  


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65081 CDR1

<400>  46

Gly Val Pro Ala Ser Ser Tyr Cys Met Gly 
1               5                   10  


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65115 CDR1

<400>  47

Gly Tyr Ile Tyr Gly Cys Met Gly 
1               5               


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65271 CDR1

<400>  48

Gly Lys Thr Tyr Gly Arg Cys Met Ala 
1               5                   


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65166 CDR1

<400>  49

Glu Asp Leu Ser Ile Tyr Gly Tyr Asn Cys Met Gly 
1               5                   10          


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65450 CDR1

<400>  50

Gly Asp Met Asn Gly Tyr Lys Cys Met Gly 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65454 CDR1

<400>  51

Gly Asp Met Asn Gly Tyr Lys Cys Met Gly 
1               5                   10  


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65131 CDR1

<400>  52

Glu Tyr Val Thr His Leu Gly 
1               5           


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65182 CDR1

<400>  53

Gly Tyr Thr Tyr Ser Tyr Gly Tyr Met Gly 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60685 CDR1

<400>  54

Gly Asn Val Tyr Asn Asn Met Cys Met Gly 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60702 CDR1

<400>  55

Gly Asn Val Tyr Asn Asn Met Cys Met Gly 
1               5                   10  


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60705 CDR1

<400>  56

Gly Tyr Ala Tyr Ser Gly Ser Cys Met Met Ala 
1               5                   10      


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60660 CDR1

<400>  57

Gly Asp Thr Gly Tyr Gln Pro Thr Met Arg 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60662 CDR1

<400>  58

Gly Tyr Arg Asn Cys Arg Ser Thr Met Arg 
1               5                   10  


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60664 CDR1

<400>  59

Gly Lys Thr Tyr Gly Arg Cys Met Ala 
1               5                   


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60668 CDR1

<400>  60

Gly Asp Met Asn Gly Tyr Lys Cys Met Gly 
1               5                   10  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60676 CDR1

<400>  61

Gly Tyr Thr Val Ser Ser Gly Cys Met Gly 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60678 CDR1

<400>  62

Gly Tyr Thr Ser Ser Arg Gly Cys Met Ser 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60679 CDR1

<400>  63

Gly Val Thr Tyr Cys Arg Leu Thr Met Arg 
1               5                   10  


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81326 CDR1

<400>  64

Glu Ser Arg Asp Cys Met Ala 
1               5           


<210>  65
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81187 CDR1

<400>  65

Gly Tyr Thr Tyr Ser Ser Tyr Ser Ser Asn Cys Leu Gly 
1               5                   10              


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533 CDR1

<400>  66

Gly Leu Ser Phe Ser Thr Tyr Thr Val Ala 
1               5                   10  


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444 CDR1

<400>  67

Gly Phe Thr Phe Ser Arg Asn Thr Met Gly 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81487 CDR1

<400>  68

Lys Leu Thr Ala Trp Arg Ser Cys Val Gly 
1               5                   10  


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126-VH CDR2

<400>  69

Tyr Ile Asn Pro Ser Thr Gly His Thr Asp Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126-VL CDR2

<400>  70

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58116-VH CDR2

<400>  71

Gly Ile Ile Pro Asn Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58116-VL CDR2

<400>  72

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58117-VH CDR2

<400>  73

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58117-VL CDR2

<400>  74

Leu Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58127-VH CDR2

<400>  75

Gly Ile Asp Pro Glu Thr Gly Gly Ala Ala Tyr Thr Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58127-VL CDR2

<400>  76

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58143-VH CDR2

<400>  77

Gly Ile Asp Pro Glu Thr Gly Gly Ala Ala Tyr Thr Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58143-VL CDR2

<400>  78

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58159-VH CDR2

<400>  79

Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58159-VL CDR2

<400>  80

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58115-VH CDR2

<400>  81

Gly Ile Ile Pro Asn Asn Gly Asp Thr Ser Tyr Lys Gln Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58115-VL CDR2

<400>  82

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  83
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58123-VH CDR2

<400>  83

Met Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58123-VL CDR2

<400>  84

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58145-VH CDR2

<400>  85

Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Asp Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58145-VL CDR2

<400>  86

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489-VH CDR2

<400>  87

Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489-VL CDR2

<400>  88

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51491-VH CDR2

<400>  89

Tyr Ile Tyr Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51491-VL CDR2

<400>  90

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110-VH CDR2

<400>  91

Tyr Ile Tyr Pro Tyr Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110-VL CDR2

<400>  92

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156-VH CDR2

<400>  93

Ser Ile Ser Ser Tyr Ser Ser Tyr Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156-VL CDR2

<400>  94

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189-VH CDR2

<400>  95

Ser Ile Tyr Ser Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189-VL CDR2

<400>  96

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674-VH CDR2

<400>  97

Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674-VL CDR2

<400>  98

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  99
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66073 CDR2

<400>  99

Val Ile Ser Ser Gly Gly Phe Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66439 CDR2

<400>  100

Ser Leu Leu Ser Thr Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65955 CDR2

<400>  101

Gln Ile His Asn Tyr Asn Ile Ala Lys Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233 CDR2

<400>  102

His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65926 CDR2

<400>  103

Ser Ile Tyr Ile Gly Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66159 CDR2

<400>  104

Ser Ile Tyr Val Gly Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66416 CDR2

<400>  105

Ser Ile Tyr Ile Gly Gly Gly Tyr Thr Asn Tyr Ser Glu Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65850 CDR2

<400>  106

Ala Ile Tyr Ser Asn Gly Ser Thr Ile Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65183 CDR2

<400>  107

Thr Met Thr Thr Thr Ser Gly Arg Thr Tyr Tyr Ala Asp Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65062 CDR2

<400>  108

Ala Met Tyr Arg Ser Gly Ser Thr Ser Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210>  109
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65065 CDR2

<400>  109

Ala Ile Tyr Ser Asp Gly Thr Thr Ser Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  110
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65556 CDR2

<400>  110

Ser Ser Tyr Arg Asp Gly Ser Gln Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  111
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65069 CDR2

<400>  111

Ala Ile Tyr Ser Asp Gln Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  112
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65691 CDR2

<400>  112

Ala Ile Tyr Ser Asp Gly Val Thr Ser Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  113
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65064 CDR2

<400>  113

Ser Ile Leu Ser Leu Tyr Ser Ser Gly Gly Lys Thr Val Tyr Ala Asp 
1               5                   10                  15      


Ser Val Lys Gly 
            20  


<210>  114
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65081 CDR2

<400>  114

Gly Ile Val Ser Asp Thr Thr Thr Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  115
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65115 CDR2

<400>  115

Thr Ile Tyr Arg Asp Gly Thr Ala Tyr Tyr Ala Asn Ser Val Glu Gly 
1               5                   10                  15      


<210>  116
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65271 CDR2

<400>  116

Ala Thr Tyr Ile Ser Gly Gly Arg Pro Tyr Val Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  117
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65166 CDR2

<400>  117

Ala Ile Tyr Thr Gly Arg Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  118
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65450 CDR2

<400>  118

Gly Ile Tyr Thr Gly Arg Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65454 CDR2

<400>  119

Gly Ile Tyr Thr Gly Arg Asn Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65131 CDR2

<400>  120

Ile Glu Ser Phe Arg Ile Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65182 CDR2

<400>  121

Lys Ile Tyr Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60685 CDR2

<400>  122

Ser Met Tyr Val Gly Gly Gly Tyr Thr Tyr Tyr Asp Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60702 CDR2

<400>  123

Ser Ile Tyr Val Gly Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  124
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60705 CDR2

<400>  124

Val Ser Val Arg Arg Thr Gly Ser Ala Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Ala 
    


<210>  125
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60660 CDR2

<400>  125

Ala Ile Tyr Ser Asp Gln Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  126
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60662 CDR2

<400>  126

Ser Ile Tyr Thr Asp Gly Thr Thr Ser Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60664 CDR2

<400>  127

Ala Thr Tyr Ile Ser Gly Gly Arg Pro Tyr Val Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60668 CDR2

<400>  128

Gly Ile Tyr Thr Gly Arg Asn Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  129
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60676 CDR2

<400>  129

Gln Ile Gly Arg Asp Ala Thr Thr Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60678 CDR2

<400>  130

Tyr Ile Asn Met Arg Val Leu Thr Thr Ile Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  131
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60679 CDR2

<400>  131

Ala Ile Tyr Ser Asp Gly Ser Thr Ala Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  132
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81326 CDR2

<400>  132

Ser Ile Tyr Ala Pro Asp Gly Ser Thr Thr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  133
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81187 CDR2

<400>  133

Arg Ile Tyr Pro Asn Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  134
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533 CDR2

<400>  134

Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444 CDR2

<400>  135

Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp Ser Val Gly 
1               5                   10                  15      


Gly 
    


<210>  136
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81487 CDR2

<400>  136

Ala Ile Tyr Ser Gly Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126-VH CDR3

<400>  137

Ser Asn Trp Ala Trp Phe Pro Tyr 
1               5               


<210>  138
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126-VL CDR3

<400>  138

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  139
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58116-VH CDR3

<400>  139

Arg Phe Ala Tyr 
1               


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58116-VL CDR3

<400>  140

Trp Gln Gly Thr His Phe Pro Phe Thr 
1               5                   


<210>  141
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58117-VH CDR3

<400>  141

Gly Leu Arg Arg Phe Ala Tyr 
1               5           


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58117-VL CDR3

<400>  142

Gln Gln Asn Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  143
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58127-VH CDR3

<400>  143

Tyr Gly Asn Tyr Pro Leu Asp Ser 
1               5               


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58127-VL CDR3

<400>  144

Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   


<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58143-VH CDR3

<400>  145

Tyr Gly Asn Tyr Pro Leu Asp Ser 
1               5               


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58143-VL CDR3

<400>  146

Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   


<210>  147
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58159-VH CDR3

<400>  147

Gly Gly Ser Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  148
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58159-VL CDR3

<400>  148

Gln Gln Tyr Ser Lys Val Pro Tyr Thr 
1               5                   


<210>  149
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58115-VH CDR3

<400>  149

Arg Phe Ala Tyr 
1               


<210>  150
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58115-VL CDR3

<400>  150

Trp Gln Gly Thr His Phe Pro Phe Thr 
1               5                   


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58123-VH CDR3

<400>  151

Ser Leu Gly Trp Tyr Phe Asp Ile 
1               5               


<210>  152
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58123-VL CDR3

<400>  152

His Gln Tyr Leu Ser Ser Trp Thr 
1               5               


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58145-VH CDR3

<400>  153

Ser Asn Trp Ala Trp Phe Pro Tyr 
1               5               


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58145-VL CDR3

<400>  154

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489-VH CDR3

<400>  155

Tyr Tyr Pro Tyr Tyr Gly Met Asp Tyr 
1               5                   


<210>  156
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489-VL CDR3

<400>  156

Gln Gln Gly Phe Ser Tyr Tyr Pro Ile Thr 
1               5                   10  


<210>  157
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51491-VH CDR3

<400>  157

Gly Tyr Gly Met Asp Tyr 
1               5       


<210>  158
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51491-VL CDR3

<400>  158

Gln Gln Ser Tyr Tyr Trp Leu Phe Thr 
1               5                   


<210>  159
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110-VH CDR3

<400>  159

Gly Tyr Ala Leu Asp Tyr 
1               5       


<210>  160
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110-VL CDR3

<400>  160

Gln Gln Ala Ser Ser Gly Tyr His Tyr Leu Ile Thr 
1               5                   10          


<210>  161
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156-VH CDR3

<400>  161

Tyr Tyr Ala Met Asp Tyr 
1               5       


<210>  162
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156-VL CDR3

<400>  162

Gln Gln Gly Pro Tyr Tyr His Pro Ile Thr 
1               5                   10  


<210>  163
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189-VH CDR3

<400>  163

Tyr Trp Gly Met Asp Tyr 
1               5       


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189-VL CDR3

<400>  164

Gln Gln Tyr Tyr Trp Tyr Tyr Pro Ile Thr 
1               5                   10  


<210>  165
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674-VH CDR3

<400>  165

Pro Phe Gly Trp Gly Tyr Ala Gly Met Asp Tyr 
1               5                   10      


<210>  166
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674-VL CDR3

<400>  166

Gln Gln Gly Tyr Ala Pro Ile Thr 
1               5               


<210>  167
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66073 CDR3

<400>  167

Gly Leu Ser Tyr Cys His Ser Ser Thr Ala Thr Ala Thr Tyr 
1               5                   10                  


<210>  168
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66439 CDR3

<400>  168

Ala Glu Trp Gly Gly Met Asp Tyr 
1               5               


<210>  169
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65955 CDR3

<400>  169

Pro Val Asp Cys Ser Trp Ser Met Phe Leu Gln Asp Pro Leu Ala Leu 
1               5                   10                  15      


Ser Pro Pro 
            


<210>  170
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233 CDR3

<400>  170

Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp Phe 
1               5                   10                  15      


<210>  171
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65926 CDR3

<400>  171

Val Ser Ile Ala Leu Thr Arg Glu Phe Cys Ala Pro Ile Val Ser Arg 
1               5                   10                  15      


Tyr Asn Tyr 
            


<210>  172
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66159 CDR3

<400>  172

Ile Thr Val Ala Leu Thr Arg Ala Phe Cys Ala Pro Ile Pro Ser Arg 
1               5                   10                  15      


Tyr Thr Asn 
            


<210>  173
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66416 CDR3

<400>  173

Ile Pro Ile Ala Leu Thr Arg Ala Phe Cys Ala Pro Ile Val Ser Arg 
1               5                   10                  15      


Tyr Thr Tyr 
            


<210>  174
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65850 CDR3

<400>  174

Gly Arg Cys Gly Gly Pro Asn Tyr 
1               5               


<210>  175
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65183 CDR3

<400>  175

His Leu Pro Ser Ser Trp Val Thr Ser Thr Asp Tyr Cys Asp Asn Leu 
1               5                   10                  15      


Gln Ala Gly Phe Tyr Asn Ser 
            20              


<210>  176
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65062 CDR3

<400>  176

Thr Ser Pro Met Gly Asp Thr Tyr 
1               5               


<210>  177
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65065 CDR3

<400>  177

Asp Leu Val Gly Cys Asn Val Ala Gly Gly Ser Pro Tyr 
1               5                   10              


<210>  178
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65556 CDR3

<400>  178

Ala Cys Pro Trp Arg Ala Tyr 
1               5           


<210>  179
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65069 CDR3

<400>  179

Thr Thr Arg Arg Gly Ser Glu Tyr 
1               5               


<210>  180
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65691 CDR3

<400>  180

Thr Gly Ser Gly Gly Val Ala Tyr 
1               5               


<210>  181
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65064 CDR3

<400>  181

Val Arg Val Thr Val Thr Trp Ala Glu Lys Leu Arg Arg Cys Thr Gly 
1               5                   10                  15      


Phe Ser Gly Met Asp Tyr 
            20          


<210>  182
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65081 CDR3

<400>  182

Ser His Phe Leu Leu Cys Ala Arg Lys Pro Arg Trp Asp Asp Leu Ile 
1               5                   10                  15      


Lys Tyr Glu Tyr 
            20  


<210>  183
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65115 CDR3

<400>  183

Arg Thr Thr Gly Cys Asn Trp Asp Ile Ser Gly Val Tyr 
1               5                   10              


<210>  184
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65271 CDR3

<400>  184

Gly Ser Ala Gly Arg Gly Pro Cys Asp Arg Phe Asp Gln Asn Gln Tyr 
1               5                   10                  15      


Thr Phe 
        


<210>  185
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65166 CDR3

<400>  185

Lys Tyr Cys Ala Val Val Ala Asp Phe Gly Asn Ser Arg Leu Val Arg 
1               5                   10                  15      


Tyr 
    


<210>  186
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65450 CDR3

<400>  186

Lys Tyr Cys Ala Val Val Ala Glu Phe Gly Gly Pro Arg Leu Val Arg 
1               5                   10                  15      


Tyr 
    


<210>  187
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65454 CDR3

<400>  187

Tyr Cys Ala Val Val Ala Glu Phe Arg Gly Pro Arg Leu Asp Arg Tyr 
1               5                   10                  15      


<210>  188
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65131 CDR3

<400>  188

Arg Gln Asp Arg Ser Gly Ala Ser Met Val Asn Arg Asp Ser Tyr Asn 
1               5                   10                  15      


Tyr 
    


<210>  189
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65182 CDR3

<400>  189

Asn Arg Leu Pro Asn Ser Asp Val Asp Leu Val Leu Pro Arg Phe Gly 
1               5                   10                  15      


Arg Phe Gly Tyr 
            20  


<210>  190
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60685 CDR3

<400>  190

Ile Ser Ile Ala Leu Thr Arg Glu Phe Cys Ala Pro Ile Val Ser Arg 
1               5                   10                  15      


Tyr Asn Tyr 
            


<210>  191
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60702 CDR3

<400>  191

Ile Thr Val Ala Leu Thr Arg Ala Phe Cys Ala Pro Ile Pro Ser Arg 
1               5                   10                  15      


Tyr Thr Asn 
            


<210>  192
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60705 CDR3

<400>  192

Asp Phe Thr Cys Arg Thr Trp Thr Leu Asn Lys Asn Tyr Asn His 
1               5                   10                  15  


<210>  193
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60660 CDR3

<400>  193

Thr Thr Arg Arg Gly Ser Glu Tyr 
1               5               


<210>  194
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60662 CDR3

<400>  194

Asp Leu Val Gly Cys Asn Val Ala Gly Gly Ser Pro Tyr 
1               5                   10              


<210>  195
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60664 CDR3

<400>  195

Gly Ser Ala Gly Arg Gly Pro Cys Asp Arg Phe Asp Gln Asn Gln Tyr 
1               5                   10                  15      


Thr Phe 
        


<210>  196
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60668 CDR3

<400>  196

Lys Tyr Cys Ala Val Val Ala Glu Phe Gly Gly Pro Arg Leu Val Arg 
1               5                   10                  15      


Tyr 
    


<210>  197
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60676 CDR3

<400>  197

Tyr Trp Gly Val Tyr Cys Leu Ser Pro Gly Arg Tyr 
1               5                   10          


<210>  198
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60678 CDR3

<400>  198

Gly Tyr Asn Gly Gln Trp Cys Glu His Ala Ser Asp Val Thr Ala 
1               5                   10                  15  


<210>  199
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60679 CDR3

<400>  199

Asn Cys Ala Ser Gly Leu Thr Ala 
1               5               


<210>  200
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81326 CDR3

<400>  200

Gly Gly Leu Ser Arg Asn Thr Cys Gly Tyr Leu Arg Gly Gly Tyr Phe 
1               5                   10                  15      


Ala Tyr 
        


<210>  201
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81187 CDR3

<400>  201

Ala Val Gly Val Gly Asp Asn Trp Cys Ala Ser Gly Ala Ala Tyr Phe 
1               5                   10                  15      


Gly Tyr 
        


<210>  202
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533 CDR3

<400>  202

Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr Asn Arg 
1               5                   10                  15      


<210>  203
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444 CDR3

<400>  203

Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn Gly Tyr Asn His 
1               5                   10                  15      


<210>  204
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81487 CDR3

<400>  204

Thr Ser Ile Arg Ser Ser Cys Gly Leu Val Arg Asp Glu Tyr Ala Tyr 
1               5                   10                  15      


<210>  205
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126 scFv

<400>  205

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Glu Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly His Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Trp Ala Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr 
    130                 135                 140                 


Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ser Gly Thr 
225                 230                 235                 240 


Arg Leu Glu Ile Lys 
                245 


<210>  206
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126VH3VL1 scFv

<400>  206

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly His Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Trp Ala Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
    130                 135                 140                 


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  207
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58116 scFv

<400>  207

Gln Val Gln Leu Lys Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Ile Pro Asn Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Ile Val Met Thr Gln Ala Pro Leu Thr Leu Ser Val Thr Ile Gly 
    130                 135                 140                 


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
145                 150                 155                 160 


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
                165                 170                 175     


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
        195                 200                 205             


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
    210                 215                 220                 


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210>  208
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58117 scFv

<400>  208

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Phe Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Phe Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Thr Ser Leu Ala Val 
    130                 135                 140                 


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val 
145                 150                 155                 160 


Asp Ser Tyr Gly Asn Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Asn Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  209
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58127 scFv

<400>  209

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asp Pro Glu Thr Gly Gly Ala Ala Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Gly Asn Tyr Pro Leu Asp Ser Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro 
    130                 135                 140                 


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe 
    210                 215                 220                 


Cys Ser Gln Ser Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Arg 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  210
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58143 scFv

<400>  210

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asp Pro Glu Thr Gly Gly Ala Ala Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Pro Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Tyr Gly Asn Tyr Pro Leu Asp Ser Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Pro Leu Ser Leu Pro 
    130                 135                 140                 


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Phe 
    210                 215                 220                 


Cys Ser Gln Ser Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys 
                


<210>  211
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58159 scFv

<400>  211

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ile Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
                165                 170                 175     


Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Ser Leu His Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys 
    


<210>  212
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58115 scFv

<400>  212

Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Ile Pro Asn Asn Gly Asp Thr Ser Tyr Lys Gln Glu Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Ile Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
    130                 135                 140                 


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
145                 150                 155                 160 


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
                165                 170                 175     


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
        195                 200                 205             


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
    210                 215                 220                 


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210>  213
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58123 scFv

<400>  213

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Leu Gly Trp Tyr Phe Asp Ile Trp Gly Ala Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val 
    130                 135                 140                 


Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val 
145                 150                 155                 160 


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
    210                 215                 220                 


Cys His Gln Tyr Leu Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  214
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58145 scFv

<400>  214

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Trp Ala Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Thr 
    130                 135                 140                 


Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys 
                245 


<210>  215
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489 scFv

<400>  215

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Pro Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly 
    210                 215                 220                 


Phe Ser Tyr Tyr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  216
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51491 scFv

<400>  216

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Tyr Pro Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser 
145                 150                 155                 160 


Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Tyr Trp 
    210                 215                 220                 


Leu Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235         


<210>  217
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110 scFv

<400>  217

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Ser 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Tyr Pro Tyr Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser 
145                 150                 155                 160 


Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Ser Gly 
    210                 215                 220                 


Tyr His Tyr Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  218
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156 scFv

<400>  218

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Ser Ser 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Tyr Ser Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser 
145                 150                 155                 160 


Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Pro Tyr Tyr 
    210                 215                 220                 


His Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235             


<210>  219
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189 scFv

<400>  219

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Tyr Ser 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Tyr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Trp Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser 
145                 150                 155                 160 


Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Trp Tyr 
    210                 215                 220                 


Tyr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235             


<210>  220
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674 scFv

<400>  220

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Phe Gly Trp Gly Tyr Ala Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Gly Tyr Ala Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  221
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66073 sdAb

<400>  221

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ala Cys Thr Gly Arg Lys Tyr Ser Ser Leu Tyr Cys 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu Gly Val Ala 
        35                  40                  45              


Val Ile Ser Ser Gly Gly Phe Thr Asn Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Ala 
65                  70                  75                  80  


Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Gly Leu Ser Tyr Cys His Ser Ser Thr Ala Thr Ala Thr Tyr Arg Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  222
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66439 sdAb

<400>  222

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Pro Gly Phe Thr Ser Ser Asp Cys 
            20                  25                  30          


Asp Met Asp Trp Tyr Arg Gln Ala Ala Gly Asn Gln Arg Glu Trp Val 
        35                  40                  45              


Ser Ser Leu Leu Ser Thr Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Lys Asp Pro Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Arg Cys Val Val Ala Glu Trp Gly Gly Met Asp Tyr Trp Gly Lys Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  223
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65955 sdAb

<400>  223

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Arg Val Ser Thr Gly 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Gly Pro Gly Glu Glu Arg Glu Gly Leu 
        35                  40                  45              


Ala Gln Ile His Asn Tyr Asn Ile Ala Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Leu Tyr Ile Cys Thr 
                85                  90                  95      


Ala Pro Val Asp Cys Ser Trp Ser Met Phe Leu Gln Asp Pro Leu Ala 
            100                 105                 110         


Leu Ser Pro Pro Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  224
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233 sdAb

<400>  224

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Tyr Ser Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala His Ile 
        35                  40                  45              


Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Val Leu Ser Arg Tyr Asn Ala Lys Ser Ile Met Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Val Lys Leu Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Arg 
                85                  90                  95      


Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  225
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65926 sdAb

<400>  225

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Leu Tyr Asn Asn Met 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ser Ile Tyr Ile Gly Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Pro Ile Ser Arg Asp Asn Ala Lys Ser 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Val Ser Ile Ala Leu Thr Arg Glu Phe Cys Ala 
            100                 105                 110         


Pro Ile Val Ser Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  226
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66159 sdAb

<400>  226

Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Val Tyr Asn Asn Met 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ser Ile Tyr Val Gly Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ile Thr Val Ala Leu Thr Arg Ala Phe Cys Ala Pro Ile Pro 
            100                 105                 110         


Ser Arg Tyr Thr Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  227
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS66416 sdAb

<400>  227

Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Leu Tyr Asn Asn Met 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Gly Ser Ile Tyr Ile Gly Gly Gly Tyr Thr Asn Tyr Ser Glu Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Lys Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ile Pro Ile Ala Leu Thr Arg Ala Phe Cys Ala Pro Ile Val 
            100                 105                 110         


Ser Arg Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  228
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65850 sdAb

<400>  228

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Tyr Ser Asn Ile 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Tyr Ser Asn Gly Ser Thr Ile Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Lys Glu Phe Ala Lys Asn Thr Gln Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Arg Cys Gly Gly Pro Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  229
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65183 sdAb

<400>  229

Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ser Asn Gly Tyr Tyr Asn Arg Arg Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Thr Met Thr Thr Thr Ser Gly Arg Thr Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Gln Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Leu Pro Ser Ser Trp Val Thr Ser Thr Asp Tyr Cys Asp 
            100                 105                 110         


Asn Leu Gln Ala Gly Phe Tyr Asn Ser Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  230
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65062 sdAb

<400>  230

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Val Val Asn Phe 
            20                  25                  30          


Ala Met Arg Trp Tyr Arg Gln Ala Pro Gly Asn Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Met Tyr Arg Ser Gly Ser Thr Ser Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Leu Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Ser Gly Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


Ala Thr Ser Pro Met Gly Asp Thr Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  231
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65065 sdAb

<400>  231

Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Tyr Cys Arg Ser 
            20                  25                  30          


Thr Met Arg Trp Tyr Arg Gln Ala Pro Gly Asn Val Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Tyr Ser Asp Gly Thr Thr Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Pro Glu Asp Thr Ala Met Tyr Tyr Cys Arg 
                85                  90                  95      


Ile Asp Leu Val Gly Cys Asn Val Ala Gly Gly Ser Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  232
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65556 sdAb

<400>  232

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asn Ala Ser Ile Cys 
            20                  25                  30          


Arg Met Ser Trp Tyr Arg Gln Ala Pro Gly Thr Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ser Tyr Arg Asp Gly Ser Gln Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Ser Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Ser Asp Thr Ala Met Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Ala Cys Pro Trp Arg Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  233
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65069 sdAb

<400>  233

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Thr Gly Tyr Gln Pro 
            20                  25                  30          


Thr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Tyr Ser Asp Gln Thr Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Arg Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ala Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      


Leu Thr Thr Arg Arg Gly Ser Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  234
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65691 sdAb

<400>  234

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Tyr Thr Asp Tyr Arg Leu 
            20                  25                  30          


Val Leu Arg Trp Tyr Arg Gln Ala Leu Gly Lys Glu Arg Glu Phe Ile 
        35                  40                  45              


Ser Ala Ile Tyr Ser Asp Gly Val Thr Ser Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      


Ala Thr Gly Ser Gly Gly Val Ala Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  235
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65064 sdAb

<400>  235

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Asp Thr Val Gln Thr Asn 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Ser Ile Leu Ser Leu Tyr Ser Ser Gly Gly Lys Thr Val Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Pro Asp Asn Ala Gln Asn 
65                  70                  75                  80  


Thr Val Ser Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Thr Val Arg Val Thr Val Thr Trp Ala Glu Lys Leu 
            100                 105                 110         


Arg Arg Cys Thr Gly Phe Ser Gly Met Asp Tyr Trp Gly Lys Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser 
    130                 


<210>  236
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65081 sdAb

<400>  236

Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Pro Ala Ser Ser Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Ile Val Ser Asp Thr Thr Thr Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser His Phe Leu Leu Cys Ala Arg Lys Pro Arg Trp Asp Asp Leu 
            100                 105                 110         


Ile Lys Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  237
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65115 sdAb

<400>  237

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Gly Cys Met 
            20                  25                  30          


Gly Trp Phe Arg Arg Ala Pro Gly Lys Ala Arg Glu Glu Val Ala Thr 
        35                  40                  45              


Ile Tyr Arg Asp Gly Thr Ala Tyr Tyr Ala Asn Ser Val Glu Gly Arg 
    50                  55                  60                  


Phe Thr Ala Ser Arg Asn Asn Ala Glu Asn Thr Leu Ser Leu Glu Met 
65                  70                  75                  80  


Asn Ser Leu Asn Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Arg 
                85                  90                  95      


Thr Thr Gly Cys Asn Trp Asp Ile Ser Gly Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  238
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65271 sdAb

<400>  238

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Lys Thr Tyr Gly Arg Cys 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Ala Thr Tyr Ile Ser Gly Gly Arg Pro Tyr Val Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Met Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Asp Asp Ser Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Ser Ala Gly Arg Gly Pro Cys Asp Arg Phe Asp Gln Asn Gln 
            100                 105                 110         


Tyr Thr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  239
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65166 sdAb

<400>  239

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Asp Leu Ser Ile Tyr Gly 
            20                  25                  30          


Tyr Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Ala Val Ala Ala Ile Tyr Thr Gly Arg Gly Thr Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Lys Tyr Cys Ala Val Val Ala Asp Phe Gly Asn Ser 
            100                 105                 110         


Arg Leu Val Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  240
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65450 sdAb

<400>  240

Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Met Asn Gly Tyr Lys 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Tyr Thr Gly Arg Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Tyr Cys Ala Val Val Ala Glu Phe Gly Gly Pro Arg Leu 
            100                 105                 110         


Val Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  241
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65454 sdAb

<400>  241

Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Met Asn Gly Tyr Lys 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Tyr Thr Gly Arg Asn Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Leu Phe Thr Ile Ser Gln Asp Asn Ala Gln Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Tyr Cys Ala Val Val Ala Glu Phe Arg Gly Pro Arg Leu Asp 
            100                 105                 110         


Arg Tyr Trp Gly Tyr Gly Thr Gln Val Thr Val Thr Ser 
        115                 120                 125 


<210>  242
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65131 sdAb

<400>  242

Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Thr Ala Ser Glu Tyr Val Thr His Leu Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ile Glu 
        35                  40                  45              


Ser Phe Arg Ile Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser His Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Arg 
                85                  90                  95      


Gln Asp Arg Ser Gly Ala Ser Met Val Asn Arg Asp Ser Tyr Asn Tyr 
            100                 105                 110         


Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  243
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65182 sdAb

<400>  243

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Tyr Gly 
            20                  25                  30          


Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Lys Ile Tyr Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Arg Arg Asn Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ala Pro Glu Asp Thr Gly Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Arg Leu Pro Asn Ser Asp Val Asp Leu Val Leu Pro Arg 
            100                 105                 110         


Phe Gly Arg Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  244
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60685 sdAb

<400>  244

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Val Tyr Asn Asn Met 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ser Met Tyr Val Gly Gly Gly Tyr Thr Tyr Tyr Asp Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ile Ser Ile Ala Leu Thr Arg Glu Phe Cys Ala Pro Ile Val 
            100                 105                 110         


Ser Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  245
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60702 sdAb

<400>  245

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Val Tyr Asn Asn Met 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ser Ile Tyr Val Gly Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ile Thr Val Ala Leu Thr Arg Ala Phe Cys Ala Pro Ile Pro 
            100                 105                 110         


Ser Arg Tyr Thr Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  246
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60705 sdAb

<400>  246

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ala Tyr Ser Gly Ser 
            20                  25                  30          


Cys Met Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
        35                  40                  45              


Val Ala Val Ser Val Arg Arg Thr Gly Ser Ala Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asn Leu Lys Val Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Phe Thr Cys Arg Thr Trp Thr Leu Asn Lys Asn Tyr 
            100                 105                 110         


Asn His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  247
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60660 sdAb

<400>  247

Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asp Thr Gly Tyr Gln Pro 
            20                  25                  30          


Thr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Tyr Ser Asp Gln Thr Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Arg Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ala Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      


Leu Thr Thr Arg Arg Gly Ser Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  248
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60662 sdAb

<400>  248

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Arg Asn Cys Arg Ser 
            20                  25                  30          


Thr Met Arg Trp Tyr Arg Gln Gly Pro Gly Gln Val Arg Asp Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Thr Asp Gly Thr Thr Ser Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ala Gln Asp Lys Gly Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Pro Glu Asp Thr Ala Met Tyr Tyr Cys Arg 
                85                  90                  95      


Ile Asp Leu Val Gly Cys Asn Val Ala Gly Gly Ser Pro Tyr Trp Gly 
            100                 105                 110         


His Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  249
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60664 sdAb

<400>  249

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Lys Thr Tyr Gly Arg Cys 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Ala Thr Tyr Ile Ser Gly Gly Arg Pro Tyr Val Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Met Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Asp Asp Ser Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Ser Ala Gly Arg Gly Pro Cys Asp Arg Phe Asp Gln Asn Gln 
            100                 105                 110         


Tyr Thr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  250
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60668 sdAb

<400>  250

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Met Asn Gly Tyr Lys 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Tyr Thr Gly Arg Asn Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Lys Tyr Cys Ala Val Val Ala Glu Phe Gly Gly Pro Arg Leu 
            100                 105                 110         


Val Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  251
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60676 sdAb

<400>  251

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Val Ser Ser Gly 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Gln Ile Gly Arg Asp Ala Thr Thr Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ala Arg Asp Asp Ala Glu Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Ser Cys Thr 
                85                  90                  95      


Ala Tyr Trp Gly Val Tyr Cys Leu Ser Pro Gly Arg Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  252
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60678 sdAb

<400>  252

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Thr Ser Ser Arg Gly 
            20                  25                  30          


Cys Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Tyr Ile Asn Met Arg Val Leu Thr Thr Ile Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Tyr Asn Gly Gln Trp Cys Glu His Ala Ser Asp Val Thr 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  253
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60679 sdAb

<400>  253

Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Arg Ser Gly Val Thr Tyr Cys Arg Leu 
            20                  25                  30          


Thr Met Arg Trp Tyr Arg Gln Ala Pro Gly Ser Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Tyr Ser Asp Gly Ser Thr Ala Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Met Ser Gln Asp Asp Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Val Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      


Leu Asn Cys Ala Ser Gly Leu Thr Ala Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  254
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81326 sdAb

<400>  254

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Glu Ser Arg Asp Cys Met Ala 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu Gly Val Ala Ser Ile 
        35                  40                  45              


Tyr Ala Pro Asp Gly Ser Thr Thr Tyr Ala Asp Thr Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Gln Pro Glu Asp Ala Ala Met Tyr His Cys Ala Ile Gly 
                85                  90                  95      


Gly Leu Ser Arg Asn Thr Cys Gly Tyr Leu Arg Gly Gly Tyr Phe Ala 
            100                 105                 110         


Tyr Phe Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  255
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81187 sdAb

<400>  255

Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Tyr 
            20                  25                  30          


Ser Ser Asn Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Ala Val Ala Arg Ile Tyr Pro Asn Ser Gly Ser Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Val Ala Val Gly Val Gly Asp Asn Trp Cys Ala Ser 
            100                 105                 110         


Gly Ala Ala Tyr Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  256
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533 sdAb

<400>  256

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Leu Ser Phe Ser Thr Tyr 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr 
            100                 105                 110         


Asn Arg Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  257
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444 sdAb

<400>  257

Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp Ser Val 
    50                  55                  60                  


Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Glu Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn Gly Tyr 
            100                 105                 110         


Asn His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  258
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS81487 sdAb

<400>  258

Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Leu Val Ser Lys Leu Thr Ala Trp Arg Ser 
            20                  25                  30          


Cys Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Tyr Ser Gly Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Gln Asp Tyr Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Thr Ser Ile Arg Ser Ser Cys Gly Leu Val Arg Asp Glu Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  259
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD58126 scFV

<400>  259
caggtgcagc tgaagcagtc tggggctgaa ctggcaaaac ctggggcctc agtggagatg       60

tcctgcaagg cttctggcta cacctttact agctactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gtactggtca tactgactac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatccaac      300

tgggcctggt ttccttactg gggccaaggg actctggtca ctgtctcgag cggtggaggc      360

ggttcaggcg gaggtggctc tggcggtggc gggtcggaca ttgtgatgac tcagtctcca      420

tcctccctga ctgtgacagc aggagagaag gtcactatga gctgcaagtc cagtcagagt      480

ctgttaaaca gtggaaatca aaagaactac ttgacctggt accagcagaa accagggaag      540

cctcctaaac tgttgatcta ctgggcatcc actagggaat ctggggtccc tgatcgcttc      600

acaggcagtg gatctggaac agatttcact ctcaccatca gcagtgtgca ggctgaagac      660

ctggcagttt attactgtca gaatgattat agttatccgc tcacgttcgg ttctgggacc      720

agactggaaa taaaa                                                       735


<210>  260
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD58126VH3VL1 scFV

<400>  260
caggtgcagc tggtgcagtc cggagcagag gtgaagaagc caggagccag cgtgaaggtg       60

tcctgcaagg cctctggcta caccttcaca agctattgga tgcactgggt gaagcaggca      120

ccaggacagg gactggagtg gatcggctac atcaatccct ccacaggcca caccgactat      180

aaccagaagt ttaaggatcg ggccaccctg acagccgaca cctctacaag caccgtgtac      240

atggagctga gctccctgag gtccgaggat acagccgtgt actattgcgc ccgctctaat      300

tgggcctggt tcccctattg gggccagggc acactggtga ccgtgtctag cggaggagga      360

ggatccggag gaggaggatc tggcggcggc ggcagcgata tcgtgatgac acagtcccct      420

gactctctgg ccgtgtctct gggagagagg gcaaccatca actgtaagtc ctctcagagc      480

ctgctgaact ccggcaatca gaagaactac ctgacctggt atcagcagaa gcctggccag      540

ccccctaagc tgctgatcta ctgggcatct acaagggaga gcggagtgcc agatagattc      600

tccggctctg gcagcggcac cgactttaca ctgaccatca gctccctgca ggccgaggat      660

gtggccgtgt actattgtca gaatgactac agctatcccc tgacatttgg cggcggcacc      720

aagctggaga tcaag                                                       735


<210>  261
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD58116 scFV

<400>  261
caggtgcagc tgaaggagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaaga cttctggata cacattcact gaatacacca tgaactgggt gaggcagagc      120

catggaaaga gccttgagtg gattggaggt attattccta acaatggtga tactagctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggaactcc gcagcctgac atctgaggat tctgcagtct attactgtgc agggcggttt      300

gcttactggg gccaagggac tctggtcact gtctcgagcg gtggaggcgg ttcaggcgga      360

ggtggctctg gcggtggcgg gtcggatatt gtgatgaccc aggctccact cactttgtcg      420

gttaccattg gacaaccagc ctccatctct tgcaagtcaa gtcagagcct cttagatagt      480

gatggaaaga catatttgaa ttggttctta cagaggccag gccagtctcc aaagcgccta      540

atctatctgg tgtctaaact ggactctgga gtccctgaca ggttcactgg cagtggatca      600

gggacagatt tcacactgaa aatcagcaga gtggaggctg aggatttggg agtttattat      660

tgctggcaag gtacacattt tccattcacg ttcggctcgg gcacaaagtt ggaaataaaa      720


<210>  262
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD58117 scFV

<400>  262
caggtccagc tgcagcagtc tggacctgag ctgaagaagc ctggagagac cgtcaagatc       60

tcctgcaagg cttcttttta taccttcaca gcctattcaa tgcactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacactg agactggtga gccaacatat      180

gcagatgact tcaagggacg gtttgccttc tctttggaaa cctctgccac cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat ttttctgtgc taggggacta      300

cggcggtttg cttactgggg ccaggggact ctggtcactg tctcgagcgg tggaggcggt      360

tcaggcggag gtggctctgg cggtggcggg tcggacattg tgatgacaca gtctccaact      420

tctttggctg tgtctctagg gcagagggcc accatatcct gcagagccag tgaaagtgtt      480

gatagttatg gcaatagttt tatgaattgg taccagcaga aaccaggaca gccacccaaa      540

ctcctcatct atcttgcatc ctacctagaa tctggggtcc ctgccaggtt cagtggcagt      600

gggtctagga cagacttcac cctcaccatt gatcctgtgg aggctgatga tgctgcaacc      660

tattactgtc agcaaaataa tgaggatccg tacacgttcg gaggggggac cagactggaa      720

ataaaa                                                                 726


<210>  263
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD58127 scFV

<400>  263
caggttcagc tgcagcagtc tggggctgaa ctggtgaggc ctggggcttc agtgacgctg       60

tcctgcaagg cttcgggcta cacatttact gactatgaaa ttcactgggt gaagcagaca      120

cctgtgcatg gcctggaatg gattggaggt attgatcctg aaactggtgg tgctgcctac      180

actcagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgccgtct attactgtac aacttatggt      300

aactaccccc ttgactcctg gggccaaggc accactctca cagtctcgag cggtggaggc      360

ggttcaggcg gaggtggctc tggcggtggc gggtcgggta ttgtgatgac ccagactcca      420

ctctccctgc ctgtcagtct tggagatcaa gcctccatct cttgcagatc tagtcagagc      480

cttgtacaca gtaatggaaa cacctattta cattggtacc tgcagaagcc aggccagtct      540

ccaaagctcc tgatctacaa agtttccaac cgattttctg gggtcccaga caggttcagt      600

ggcagtggat cagggacaga tttcacactc aagatcagca gagtggaggc tgaggatctg      660

ggagtttatt tctgctctca aagtacacat gttccgctca cgttcggtgc tgggaccaga      720

ctggaaataa aa                                                          732


<210>  264
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD58143 scFV

<400>  264
caggtgcaac tgaagcagtc tggggctgaa ctggtgaggc ctggggcttc agtgacgctg       60

tcctgcaagg cttcgggcta cacatttact gactatgaaa tgcactgggt gaagcagaca      120

cctgtgcatg gcctggaatg gatcggaggt attgatcctg aaactggtgg tgctgcctac      180

actcagaagt tcaagggcaa ggccacaccg actgcagaca aatcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgccgtct attactgtac aacttatggt      300

aactaccccc ttgactcctg gggccaaggc accacggtca ccgtctcgag cggtggaggc      360

ggttcaggcg gaggtggctc tggcggtggc gggtcggata tccagatgac acagactcca      420

ctctccctgc ctgtcagtct tggagatcaa gcctccatct cttgcagatc tagtcagagc      480

cttgtacaca gtaatggaaa cacctattta cattggtacc tgcagaagcc aggccagtct      540

ccaaagctcc tgatctacaa agtttccaac cgattttctg gggtcccaga caggttcagt      600

ggcagtggat cagggacaga tttcacactc aagatcagcg gagtggaggc tgaggatctg      660

ggagtttatt tctgctctca aagtacacat gttccgctca cgttcggtgc tgggaccaag      720

ctggagctga aa                                                          732


<210>  265
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD58159 scFV

<400>  265
caggtgcaac tgaagcagtc tggagctgag ctggtaaggc ctgggacttc agtgaagata       60

tcctgcaagg cttctggcta caccatcact aactactggc taggttgggt aaagcagagg      120

ccaggacatg gacttgagtg gattggagat atttaccctg gaggtggtta tactaactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca catcctccat cactgcctac      240

atgcagctca gtagcctgac atctgaggac tctgctgtct atttctgtgc aagaggcggt      300

agtagctact ggtacttcga tgtctggggc gcagggacct cagtcaccgt ctcgagcggt      360

ggaggcggtt caggcggagg tggctctggc ggtggcgggt cggatatcca gatgacacag      420

actacatcct ccctgtctgc ctctctggga gacagagtca ccatcagttg cagtgcaagt      480

caggacatta gcaattattt aaactggtat cagcagaaac cagatggaac tgttaaactc      540

ctgatctatt acacatcaag tttacactca ggagtcccat caaggttcag tggcagtggg      600

tctgggacag attattctct caccatcagc aacctggaac ctgaagatat tgccacttac      660

tattgtcagc agtatagtaa ggttccgtac acgttcggag gggggaccaa gctggagctg      720

aaa                                                                    723


<210>  266
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD58115 scFV

<400>  266
caggtgcagc tgaagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaaga cttctggata cacattcact gaatacacca tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagga attattccta acaatggtga tactagctac      180

aaacaggagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgacgat tctgcagtct attactgtgc agggcggttt      300

gcttactggg gccaagggac tctggtcact gtctcgagcg gtggaggcgg ttcaggcgga      360

ggtggctctg gcggtggcgg gtcggatatt gtgatgaccc agactccact cactttgtcg      420

gttaccattg gacaaccagc ctccatctct tgcaagtcaa gtcagagcct cttagatagt      480

gatggaaaga catatttgaa ttggttctta cagaggccag gccagtctcc aaagcgccta      540

atctatctgg tgtctaaact ggactctgga gtccctgaca ggttcactgg cagtggatca      600

gggacagatt tcacactgaa aatcagcaga gtggaggctg aggatttggg agtttattat      660

tgctggcaag gtacacattt tccattcacg ttcggctcgg gcacaaagtt ggaaataaaa      720


<210>  267
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD58123 scFV

<400>  267
gaggtccagc tgcagcagtc aggacctggc ctggtggcac cctcacagag cctgtccatc       60

acatgcactg tctctgggtt ctcattatcc agatatagtg tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggaatg atatggggtg gtggaaacac agactataat      180

tcagctctca aatccagact gagcatcagc aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgccag aagcctgggc      300

tggtacttcg atatctgggg cgcagggacc acggtcaccg tctcgagcgg tggaggcggt      360

tcaggcggag gtggctctgg cggtggcggg tcggacattg tgatgacaca gtcgccatca      420

tctctggctg tgtctgcagg agaaaaggtc actatgagct gtaagtccag tcaaagtgtt      480

ttatacagtt caaatcagaa gaactacttg gcctggtacc agcagaaacc agggcagtct      540

cctaaactgc tgatctactg ggcatccact agggaatctg gtgtccctga tcgcttcaca      600

ggcagtggat ctgggacaga ttttactctt accatcagca gtgtacaagc tgaagacctg      660

gcagtttatt actgtcatca atacctctcc tcgtggacgt tcggtggagg cacaaagctg      720

gaaatcaaa                                                              729


<210>  268
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD58145 scFV

<400>  268
gaggttcagc tgcaacagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacctttact agctactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gcactggtta tactgactac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatccaac      300

tgggcctggt ttccttactg gggccaaggg actctggtca ctgtctcgag cggtggaggc      360

ggttcaggcg gaggtggctc tggcggtggc gggtcggaca tccagatgac acagtctcca      420

tcctccctga ctgtgacagc aggagagaag gtcactatga gctgcaagtc cagtcagagt      480

ctgttaaaca gtggaaatca aaagaactac ttgacctggt accagcagaa accagggcag      540

cctcctaaac tgttgatcta ctgggcatcc actagggaat ctggggtccc tgatcgcttc      600

acaggcagtg gatctggaac agatttcact ctcaccatca gcagtgtgca ggctgaagac      660

ctggcagttt attactgtca gaatgattat agttatccgc tcacgttcgg tgctgggacc      720

aagctggagc tgaaa                                                       735


<210>  269
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS51489 scFV

<400>  269
gaggttcaac tggtggagag cggtggtggt ctggttcagc cgggtggtag cctgcgtctg       60

agctgcgcag cttctggctt caacctctat tattattcta tccactgggt gcgtcaggcg      120

ccgggtaaag gcctggaatg ggttgcatat atttcttctt cttctagcta tacttattat      180

gccgatagcg tcaagggccg tttcaccatc agcgcggata ccagcaaaaa caccgcatac      240

ctgcaaatga acagcctgcg tgcggaagat accgccgtct attattgtgc tcgctactac      300

ccgtactacg gtatggacta ctggggtcaa ggcaccctgg ttaccgtgag cagcggtgga      360

ggcggttcag gcggaggtgg ctctggcggt ggcgggtcgg acatccagat gacccagagc      420

ccgagcagcc tgagcgcgag cgttggtgac cgtgttacca ttacctgccg tgcgagccag      480

agcgttagca gcgcggtggc gtggtaccag caaaagccgg gtaaagcgcc gaagctgctg      540

atctatagcg cgagcagcct gtatagcggc gttccgagcc gtttcagcgg tagccgtagc      600

ggcaccgact ttaccctgac cattagcagc ctgcagccgg aagatttcgc aacttattac      660

tgtcagcaag gtttctctta ctacccgatc acgttcggac agggcaccaa agttgagatt      720

aaa                                                                    723


<210>  270
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS51491 scFV

<400>  270
gaggttcaac tggtggagag cggtggtggt ctggttcagc cgggtggtag cctgcgtctg       60

agctgcgcag cttctggctt caacctctat tcttattcta tgcactgggt gcgtcaggcg      120

ccgggtaaag gcctggaatg ggttgcatat atttatcctt attctggctc tacttattat      180

gccgatagcg tcaagggccg tttcaccatc agcgcggata ccagcaaaaa caccgcatac      240

ctgcaaatga acagcctgcg tgcggaagat accgccgtct attattgtgc tcgcggttac      300

ggtatggact actggggtca aggcaccctg gttaccgtga gcagcggtgg aggcggttca      360

ggcggaggtg gctctggcgg tggcgggtcg gacatccaga tgacccagag cccgagcagc      420

ctgagcgcga gcgttggtga ccgtgttacc attacctgcc gtgcgagcca gagcgttagc      480

agcgcggtgg cgtggtacca gcaaaagccg ggtaaagcgc cgaagctgct gatctatagc      540

gcgagcagcc tgtatagcgg cgttccgagc cgtttcagcg gtagccgtag cggcaccgac      600

tttaccctga ccattagcag cctgcagccg gaagatttcg caacttatta ctgtcagcaa      660

tcttactact ggctgttcac gttcggacag ggcaccaaag ttgagattaa a               711


<210>  271
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS92110 scFV

<400>  271
gaggttcaac tggtggagag cggtggtggt ctggttcagc cgggtggtag cctgcgtctg       60

agctgcgcag cttctggctt caacatctat tattcttcta tgcactgggt gcgtcaggcg      120

ccgggtaaag gcctggaatg ggttgcatat atttatcctt attatagcta tacttattat      180

gccgatagcg tcaagggccg tttcaccatc agcgcggata ccagcaaaaa caccgcatac      240

ctgcaaatga acagcctgcg tgcggaagat accgccgtct attattgtgc tcgcggttac      300

gctttggact actggggtca aggcaccctg gttaccgtga gcagcggtgg aggcggttca      360

ggcggaggtg gctctggcgg tggcgggtcg gacatccaga tgacccagag cccgagcagc      420

ctgagcgcga gcgttggtga ccgtgttacc attacctgcc gtgcgagcca gagcgttagc      480

agcgcggtgg cgtggtacca gcaaaagccg ggtaaagcgc cgaagctgct gatctatagc      540

gcgagcagcc tgtatagcgg cgttccgagc cgtttcagcg gtagccgtag cggcaccgac      600

tttaccctga ccattagcag cctgcagccg gaagatttcg caacttatta ctgtcagcaa      660

gcttcttctg gttaccatta cctgatcacg ttcggacagg gcaccaaagt tgagattaaa      720


<210>  272
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS91156 scFV

<400>  272
gaggttcaac tggtggagag cggtggtggt ctggttcagc cgggtggtag cctgcgtctg       60

agctgcgcag cttctggctt caacatctat tcttcttcta tccactgggt gcgtcaggcg      120

ccgggtaaag gcctggaatg ggttgcatct atttcttctt attctagcta tacttcttat      180

gccgatagcg tcaagggccg tttcaccatc agcgcggata ccagcaaaaa caccgcatac      240

ctgcaaatga acagcctgcg tgcggaagat accgccgtct attattgtgc tcgctactac      300

gctatggact actggggtca aggcaccctg gttaccgtga gcagcggtgg aggcggttca      360

ggcggaggtg gctctggcgg tggcgggtcg gacatccaga tgacccagag cccgagcagc      420

ctgagcgcga gcgttggtga ccgtgttacc attacctgcc gtgcgagcca gagcgttagc      480

agcgcggtgg cgtggtacca gcaaaagccg ggtaaagcgc cgaagctgct gatctatagc      540

gcgagcagcc tgtatagcgg cgttccgagc cgtttcagcg gtagccgtag cggcaccgac      600

tttaccctga ccattagcag cctgcagccg gaagatttcg caacttatta ctgtcagcaa      660

ggtccgtact accatccgat cacgttcgga cagggcacca aagttgagat taaa            714


<210>  273
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS91189 scFV

<400>  273
gaggttcaac tggtggagag cggtggtggt ctggttcagc cgggtggtag cctgcgtctg       60

agctgcgcag cttctggctt caacctctct tattcttcta tccactgggt gcgtcaggcg      120

ccgggtaaag gcctggaatg ggttgcatct atttattctt attctggctc tacttattat      180

gccgatagcg tcaagggccg tttcaccatc agcgcggata ccagcaaaaa caccgcatac      240

ctgcaaatga acagcctgcg tgcggaagat accgccgtct attattgtgc tcgctactgg      300

ggtatggact actggggtca aggcaccctg gttaccgtga gcagcggtgg aggcggttca      360

ggcggaggtg gctctggcgg tggcgggtcg gacatccaga tgacccagag cccgagcagc      420

ctgagcgcga gcgttggtga ccgtgttacc attacctgcc gtgcgagcca gagcgttagc      480

agcgcggtgg cgtggtacca gcaaaagccg ggtaaagcgc cgaagctgct gatctatagc      540

gcgagcagcc tgtatagcgg cgttccgagc cgtttcagcg gtagccgtag cggcaccgac      600

tttaccctga ccattagcag cctgcagccg gaagatttcg caacttatta ctgtcagcaa      660

tactactggt actacccgat cacgttcgga cagggcacca aagttgagat taaa            714


<210>  274
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS51674 scFV

<400>  274
gaggttcaac tggtggagag cggtggtggt ctggttcagc cgggtggtag cctgcgtctg       60

agctgcgcag cttctggctt caacctctat tcttattata tgcactgggt gcgtcaggcg      120

ccgggtaaag gcctggaatg ggttgcatct atttattctt attctagcta tacttcttat      180

gccgatagcg tcaagggccg tttcaccatc agcgcggata ccagcaaaaa caccgcatac      240

ctgcaaatga acagcctgcg tgcggaagat accgccgtct attattgtgc tcgcccgttc      300

ggttggggtt acgctggtat ggactactgg ggtcaaggca ccctggttac tgtgagcagc      360

ggtggaggcg gttcaggcgg aggtggctct ggcggtggcg ggtcggacat ccagatgacc      420

cagagcccga gcagcctgag cgcgagcgtt ggtgaccgtg ttaccattac ctgccgtgcg      480

agccagagcg ttagcagcgc ggtggcgtgg taccagcaaa agccgggtaa agcgccgaag      540

ctgctgatct atagcgcgag cagcctgtat agcggcgttc cgagccgttt cagcggtagc      600

cgtagcggca ccgactttac cctgaccatt agcagcctgc agccggaaga tttcgcaact      660

tattactgtc agcaaggtta cgctccgatc acgttcggac agggcaccaa agttgagatt      720

aaa                                                                    723


<210>  275
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS66073 sdAb

<400>  275
caggttcagc tggtggagtc tgggggagac tcggtgcagg ctggggggtc tctgacactc       60

gcctgtacag ggcgtaaata cagcagtcta tactgcatgg cctggttccg ccaggctcca      120

gggaaggcgc gcgagggggt cgcagttatt agcagtggcg gcttcacaaa ttacgctgac      180

tccgtaaagg gccgattcac catctccaga gacaactcca agaacacgct gtatctggca      240

atgaacggcc tgaaacctga ggacactgcc atgtactact gtgcggcagg cctatcctat      300

tgccattcaa gcacagcaac cgccacgtac cggggccagg ggacccaggt caccgtctcc      360

tca                                                                    363


<210>  276
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS66439 sdAb

<400>  276
cagatgcagc tggtggagtc tgggggaggc tcggtgcagg ctggggggtc tctgagactc       60

tcctgcacag cccctggatt cacctccagt gactgcgaca tggactggta ccgccaggct      120

gcagggaatc agcgcgaatg ggtctcatct cttcttagta ctgacggtag cacaagctat      180

gcggactccg tgaggggccg attcaccatc tccaaagacc cagccaagga cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccatgt atttctgtag gtgtgtcgtg      300

gctgagtggg gcggcatgga ctactggggc aaaggaaccc tggtcaccgt ctcctca         357


<210>  277
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65955 sdAb

<400>  277
caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggcga ccgcgtcagt actggctgta tgggctggtt ccgccagggt      120

ccaggcgagg agcgcgaggg gctcgcacaa attcacaatt ataatatcgc aaagtacgca      180

gactccgtga agggccgatt caccatctcc aaagacaacg ccaagaacat tctgtatctg      240

caaatgaaca gcctgaaacc tgaggacact ggcttgtaca tctgtacggc tcctgtagat      300

tgtagctgga gcatgtttct gcaagaccca cttgcgttgt ctccacctag gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  278
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65233 sdAb

<400>  278
caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctgaatt cacgtacagt atgggctggt tccgccaggc tccagggaag      120

gagcgcgagg gcgtcgcaca tatttacact cgtggtggta ccacggtcta tgccgactcc      180

gtgaagggcc gattcgtcct ctcccgatac aacgccaaga gcataatgta tctacaaatg      240

aacagcgtga aacttgagga cactgccatg tattactgtg cggcccggac catattcgaa      300

ggtagctggt cgtccccatc ctcgtttgac ttctggggcc aggggaccca ggtcaccgtc      360

tcctca                                                                 366


<210>  279
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65926 sdAb

<400>  279
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggaaa cctctacaat aacatgtgca tgggctggtt ccggcaggct      120

ccagggaagg agcgcgaggg ggtcgcaagt atttatattg gtggtggtta caccaactat      180

gccgactccg tgaagggccg attcaccatc tcccccatct cccgagacaa cgccaagagc      240

acgctgtatc tgcaaatgaa cagcctgaaa cctgaggaca ctgccatgta ctactgtgcg      300

gcagtctcca tcgcgcttac gagggaattc tgcgccccga tcgtttctcg gtataattac      360

tggggccagg ggacccaggt caccgtctcc tca                                   393


<210>  280
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS66159 sdAb

<400>  280
caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcatgtgcag cctctggaaa cgtctacaat aacatgtgca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcaagt atctatgttg gtggtggtta caccaactat      180

gccgactccg tgaggggccg attcaccatc tcccaagaca acgccaagaa cacgctgtat      240

ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcaattacc      300

gtcgcgctta cgagggcttt ctgcgccccg atcccttctc ggtataccaa ctggggccag      360

gggacccagg tcaccgtctc ctca                                             384


<210>  281
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS66416 sdAb

<400>  281
caggtgcagc tggcggagtc tgggggaggt tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggaaa cctctacaat aacatgtgca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcggaagt atttatattg gtggtggtta caccaactat      180

tccgaatccg tgaggggccg attcaccatc tccctagaca acgccaagaa gacgctgaat      240

ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcaatcccc      300

atcgcgctta cgagggcttt ctgcgccccg atcgtttctc ggtatacgta ctggggccag      360

gggacccagg tcaccgtctc ctca                                             384


<210>  282
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65850 sdAb

<400>  282
gaggtgcagc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggatt ctcctacagt aacatctgta tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcggct atttatagta atggtagcac aatctacgca      180

gactccgtga agggccgatt caccgtctcc aaagaattcg ccaagaacac tcagtatctg      240

caaatgaaca gcctgaaacc tgaggacact gccatgtact actgtgcggc aggccggtgt      300

gggggcccta actactgggg ccaggggacc caggtcaccg tctcctca                   348


<210>  283
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65183 sdAb

<400>  283
gaggtgcaac tggcggagtc tgggggaggc tcggcgcagg ctggagggtc tctgagactc       60

tcctgtgcaa gcaatgggta ctacaaccgt cgctattgta tggcctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcgact atgactacta ctagtggtcg cacatactat      180

gccgacgccg tgaagggccg attcaccgtc tcccaagaca acgccaagtc cacgctgtat      240

ctgcaaatga gcagcctgaa acctgaggac actgccatgt actactgtgc ggcgcacctt      300

cccagttctt gggtgacgtc gactgattac tgcgacaact tgcaagccgg cttttataac      360

tcctggggcc aggggaccca ggtcaccgtc tcctca                                396


<210>  284
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65062 sdAb

<400>  284
caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggagt cagcgtggtt aacttcgcca tgaggtggta ccgccaggct      120

ccagggaacg agcgcgagtt cgtctcagcg atgtaccgtt ctggtagcac gtcttacgct      180

gactccgtga ggggccgatt caccatctcc cgagacagcg ccttgaacac ggtgtttctt      240

caaatgagcg gcctgaaacc tgaggacacg gccacgtatt actgtcaagc gacatcacct      300

atgggcgaca cctactgggg ccaggggacc caggtcaccg tctcctca                   348


<210>  285
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65065 sdAb

<400>  285
gaggtgcaac tggcggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggata cagctactgt aggtccacca tgcgctggta ccgccaggct      120

ccagggaacg tgcgcgaatt tgtctcagct atctatagtg atggtaccac aagctacaca      180

gactccgtga agggccgatt caccatctcc caagacaacg ccaagaacac tgtgtatcta      240

caaatgaaca gcctgcaacc tgaagacacg gccatgtatt actgtcggat agatcttgtc      300

ggatgcaacg tagctggtgg cagtccttac tggggccagg ggacccaggt caccgtctcc      360

tca                                                                    363


<210>  286
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65556 sdAb

<400>  286
caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ttggagggtc tctgagactc       60

tcctgtgcag cctctggata caacgcctct atctgccgca tgagctggta ccgccaggct      120

cccgggactg agcgcgagtt cgtctcatcg tcttacaggg atggtagcca aagctacgca      180

gactccgtga aggggcgatt caccacatcc cgagactccg ccaagaacac ggtgtttctg      240

caaatgaaca gcctgaaacc ttcggacacg gccatgtatt actgtaacgc agcttgcccc      300

tggcgggcct actggggcca ggggacccag gtcaccgtct cctca                      345


<210>  287
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65069 sdAb

<400>  287
caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgtag cctctggaga caccggctac caacctacga tgaggtggta ccgccaggct      120

ccagggaagg agcgcgagtt cgtctccgct atttatagtg atcagaccac aagctatgca      180

gactccgtga agggccggtt caccatctcc caagacaacg ccagaaaaac ggtgtatctg      240

caaatggcta gcctgaaacc tgaggacacg gccatgtatt actgtaaact cactactcgc      300

agggggtctg agtactgggg ccaggggaca caggtcaccg tctcctca                   348


<210>  288
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65691 sdAb

<400>  288
cagatgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtacag tctctggata caccgactat aggctcgtac tgaggtggta ccgccaggct      120

ctagggaagg agcgcgagtt catctcagct atttatagtg atggagtcac aagctactca      180

gactccgtga agggccgatt caccatctcc cgagacaacg ccaagaacac ggcgtatctg      240

caaatgaaca gcctgaaatc tgaggacacg gccatgtatt actgtaaagc aaccgggtcc      300

ggtggcgttg cctactgggg ccagggaacc caggtcaccg tctcctca                   348


<210>  289
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65064 sdAb

<400>  289
caggttcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgaaactc       60

tcctgtgcag tctctggaga caccgtccag actaactgta tggcctggtt ccgccaggct      120

ccagggaagg agcgcgaggc ggtcgccagc attttgagtc tttattctag tggaggtaag      180

acagtctatg ccgactccgt gaagggccga ttcaccatct ccccagacaa cgcccagaac      240

acggtgtcgc tgcaaatgaa caatttgaaa cctgaggaca ctgccatgta ctactgtgcg      300

actgtccgcg tgaccgtcac ttgggccgaa aagttgaggc gttgtaccgg attcagcggc      360

atggactact ggggcaaagg aaccctggtc accgtctcct ca                         402


<210>  290
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65081 sdAb

<400>  290
caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggagt ccccgctagt agctactgca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcaggt attgtcagtg atactaccac aacctacgca      180

gactccgtga agggccgatt caccatctcc aaagacaacg ccaagaacac tctgtatctg      240

caaatgaaca gcctgaaacc tgaggacact gccacgtact actgtgcggc ctcccatttt      300

ctattgtgcg ccagaaaacc ccgctgggat gacctcatta aatatgagta ctggggccag      360

gggacccagg tcaccgtctc ctca                                             384


<210>  291
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65115 sdAb

<400>  291
caggttcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgcgactc       60

tcctgtgcag cctctggata catttacggc tgcatgggct ggttccgccg ggctccaggg      120

aaggcgcgcg aggaggttgc gactatttac cgcgatggta cagcatacta cgcaaactcc      180

gtagagggcc gattcaccgc ctccagaaac aacgccgaga acactctgtc tctggagatg      240

aacagtctga acgctgagga cactgccatg tactactgtg cggcaagaac aactggttgt      300

aactgggaca tatctggggt ttactggggc caggggaccc aggtcaccgt ctcctca         357


<210>  292
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65271 sdAb

<400>  292
cagatgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgacactc       60

tcctgtgcag cctctggaaa aacctacgga cgctgcatgg cctggttccg ccaggctcca      120

gggaaggagc gcgagttagt cgctgctact tatattagtg gtgggcgacc ctacgttgcc      180

gactccgtga agggccgatt caccatttcc cgggacaacg ccaagagtac gatgtctctg      240

caaatgaaca gcctgagacc tgacgacagc gccatgtact actgtgcggc gggttcggcg      300

ggtcggggac cttgtgatcg cttcgaccaa aatcaatata ccttctgggg ccaggggacc      360

caggtcaccg tctcctca                                                    378


<210>  293
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65166 sdAb

<400>  293
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtacag cctctgaaga cttatctatt tacggttaca attgcatggg ctggttccgc      120

caggctccag ggaaggagcg cgaggcggtc gcagctattt atactggccg tggtaccaca      180

tactatgccg actccgtgaa gggccgattc accatctccc aagacaacgc caagaacact      240

gtgtatctgc aaatgaacag cctgaaacct gaggacactg ccatgtacta ctgtgcgtca      300

aaatactgtg cggtggtagc tgatttcggg aattctcgac tcgttcgtta ctggggccag      360

gggacccagg tcaccgtctc ctca                                             384


<210>  294
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65450 sdAb

<400>  294
caggtgaggt tagtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggaga catgaacggt tacaagtgca tggggtggtt ccgccaggct      120

ccagggaagg agcgcgaggc ggtcgcaggt atttatactg gccgtgggac cacatactat      180

gccgactccg tgaaggaccg attcaccatc tcccaagaca acgccaagaa cactgtgtat      240

ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc agcaaaatac      300

tgtgcggtgg tagctgaatt cgggggtcct cgactcgttc gttactgggg ccaggggacc      360

caggtcaccg tctcctca                                                    378


<210>  295
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65454 sdAb

<400>  295
caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactg       60

tcctgtgcag cctctggaga catgaacggt tacaagtgca tggggtggtt ccgccaggct      120

ccagggaagg agcgagaggc ggtcgcaggt atttatactg gccgtaatac tacatactat      180

gccgactccg tgaaggacct attcaccatc tcccaagaca acgcctagaa cactgtgttt      240

ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc gtcataatac      300

tgtgcggtgg tagctgaatt ccggggtcct cgactcgatc gttactgggg ctatgggacc      360

caggtcaccg tcacctca                                                    378


<210>  296
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65131 sdAb

<400>  296
gaggtgcagc tggcggagtc tgggggaggc tcggtgcagg ctggagggtc tctgacactc       60

tcctgtacag cctctgaata cgtcacacac ttgggctggt tccgccaggc tccagggaag      120

gagcgcgagg gggtcgcaat cgaaagtttt cgtattggtt atacatacta tgccgactcc      180

gtgaagggtc gattcaccat ctcccacgac aacgccaaga acacgctgta tctgcaaatg      240

aacagcctga aacctgagga cactgccata tactactgtg cggctcggca ggaccgatcg      300

ggggcttcca tggtaaatcg agattcatat aattactggg gcaaggggac ccaggtcacc      360

gtctcctca                                                              369


<210>  297
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS65182 sdAb

<400>  297
caggtgaagt tagtggagtc agggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cgtctggata cacgtacagt tacggctaca tgggctggtt ccggcaggct      120

ccagggaagg agcgcgaggg ggtcgcaaag atttataatg gtgacggtag tacatactat      180

gccgactccg tgaagggccg attcaccatc tcccaagacc gccgcaacaa cacgctgtat      240

ctgcaaatga acagtctggc acctgaggac actggcatgt actactgtgc gacaaaccga      300

ctcccaaata gcgacgttga cttggtcctt ccccggttcg gccgttttgg ttactggggc      360

caggggaccc aggtcaccgt ctcctca                                          387


<210>  298
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS60685 sdAb

<400>  298
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggtaa tgtctacaat aacatgtgca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcaagt atgtatgttg gtggtggtta cacctactat      180

gacgactccg tgaagggccg attcaccatc tcccgagaca acgccaagaa cacgctgtat      240

ctgcaaatga acagcctgaa acctgaagac actgccatgt actactgtgc ggcaatctcc      300

atcgcgctta cgagggaatt ctgcgccccg atcgtttctc ggtataatta ttggggccag      360

gggacccagg tcaccgtctc ctca                                             384


<210>  299
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS60702 sdAb

<400>  299
caggtgaagt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcatgtgcag cctctggaaa cgtctacaat aacatgtgca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcaagt atctatgttg gtggtggtta caccaactat      180

gccgactccg tgaggggccg attcaccatc tcccaagaca acgccaagaa cacgctgtat      240

ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcaattacc      300

gtcgcgctta cgagggcttt ctgcgccccg atcccttctc ggtataccaa ctggggccag      360

gggacccagg tcaccgtctc ctca                                             384


<210>  300
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS60705 sdAb

<400>  300
caggtgcagc tggtggagtc tgggggaggc tcggtgcagt ctggagggtc tctgagactc       60

tcctgtgcag cctctggata cgcctacagt gggtcttgca tgatggcctg gttccgccag      120

gctccaggga aggagcgcga gggggtcgca gttagcgttc gtcgtacggg aagcgcattc      180

tatgccgact ccgtgaaggc ccgattcacc atctcccgcg acaatgccaa gaacacgctg      240

tatctgcaaa tgaataacct gaaagttgag gacactgcca tgtactactg tgcggcagat      300

tttacttgtc gtacgtggac tctcaataaa aattacaacc actggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210>  301
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS60660 sdAb

<400>  301
caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgtag cctctggaga caccggctac caacctacga tgaggtggta ccgccaggct      120

ccagggaagg agcgcgagtt cgtctccgct atttatagtg atcagaccac aagctatgca      180

gactccgtga agggccggtt caccatctcc caagacaacg ccagaaaaac ggtgtatctg      240

caaatggcta gcctgaaacc tgaggacacg gccatgtatt actgtaaact cactactcgc      300

agggggtctg agtactgggg ccaggggaca caggtcaccg tctcctca                   348


<210>  302
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS60662 sdAb

<400>  302
caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgtag cctctggata caggaactgt aggtccacca tgcgctggta ccgccagggt      120

ccaggacagg tgcgagactg ggtctcaagt atctatactg atggtaccac aagctacaca      180

gactccgtga agggccgatt caccatcgcc caagacaaag gcaagaacac ggtgtatcta      240

caaatgaaca gcctgcaacc tgaagacacg gccatgtatt actgtcggat agatcttgtc      300

ggatgcaatg tagctggtgg cagtccttac tggggccatg ggacccaggt caccgtctcc      360

tca                                                                    363


<210>  303
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS60664 sdAb

<400>  303
caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgacactc       60

tcctgtgcag cctctggaaa aacctacgga cgctgcatgg cctggttccg ccaggctcca      120

gggaaggagc gcgagttagt cgctgctact tatattagtg gtgggcgacc ctacgttgcc      180

gactccgtga agggccgatt caccatttcc cgggacaacg ccaagagtac gatgtctctg      240

caaatgaaca gcctgagacc tgacgacagc gccatgtact actgtgcggc gggttcggcg      300

ggtcggggac cttgtgatcg cttcgaccaa aatcaatata ccttctgggg ccaggggacc      360

caggtcaccg tctcctca                                                    378


<210>  304
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS60668 sdAb

<400>  304
caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactg       60

tcctgtgcag cctctggaga catgaacggt tacaagtgca tggggtggtt ccgccaggct      120

ccagggaagg agcgcgaggc ggtcgcaggt atttatactg gccgtaatac tacatactat      180

gccgactccg tgaaggaccg attcaccatc tcccaagaca acgccaagaa cactgtgttt      240

ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc gtcaaaatac      300

tgtgcggtgg tagctgaatt cgggggtcct cgactcgttc gttactgggg ccaggggacc      360

caggtcaccg tctcctca                                                    378


<210>  305
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS60676 sdAb

<400>  305
caggtgcagc tggtggagtc tgggggaggg tcggtgcagg ctggagggtc tctgagactc       60

tcctgcgcag cctctggata caccgtcagt agcggctgca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgagcg ggtcgcacag attggtcgtg atgctaccac gacctacgca      180

gactccgtga agggccgatt caccatcgcc agagacgacg ccgagaacac tctgtatctg      240

caaatgaaca gcctgaaacc tgaagacact gccatgtaca gctgtacggc ctattggggt      300

gtatactgtt tatctccagg acgctactgg ggccagggga cccaggtcac cgtctcctca      360


<210>  306
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS60678 sdAb

<400>  306
caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag tctctggata cacctccagt cgcggttgca tgagctggtt ccgccaggct      120

ccagggaagg agcgcgagag ggtcgcatac attaatatgc gtgtcctaac cacaatctat      180

gccgcctccg tgaaggaccg attcgccatc tccagagaca acgccaagaa cacggtggat      240

ctgcaaatga acaacctgaa acctgaggac actgccatgt actactgcgc ggcggggtac      300

aatggacaat ggtgcgaaca tgctagtgac gttactgcct ggggtcaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  307
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS60679 sdAb

<400>  307
caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcac gctctggagt cacctattgt aggttgacca tgaggtggta ccgccaggct      120

ccagggagcg agcgcgagtt cgtctccgct atttatagtg atggtagcac agcctacgca      180

gactccgtga agggtcgatt caccatgtcc caagacgacg ccaagaacac ggtgtatctg      240

caaatgaaca gcgtgaaacc tgaggacacg gccatgtatt attgtaaatt gaattgtgcg      300

tccggcttga ctgcctgggg ccaggggacc caggtcaccg tctcctca                   348


<210>  308
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS81326 sdAb

<400>  308
gaggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgacactc       60

tcctgtgcag cctccgagag tagggattgt atggcctggt tccgccaggc tccagggaag      120

gcgcgcgagg gggtcgcatc tatttatgct ccggatggta gcacaaccta tgccgacacc      180

gtgaagggcc gattcaccat ctcccaagac aacgccaaga acacgctgta tctgcaaatg      240

aacagcctgc aacctgagga cgctgccatg taccactgtg cgatcggggg gctgtcacgc      300

aatacttgtg gttacctcag aggcggatac tttgcttact ttggccgggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  309
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS81187 sdAb

<400>  309
caggtgaggt tggtggagtc tgggggcggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggata cacctacagc agctacagta gcaactgcct gggctggttc      120

cgccaggctc cagggaagga gcgcgaggca gtcgcacgta tctatcctaa cagtggtagc      180

acatactatg ccgactccgt gaagggccgc ttcaccatct cccaagacaa cgccaagaac      240

acggtgtatc tacaaatgaa cagcctgaaa cctgaggaca ctgccatgta ctactgtgcg      300

gtagcagtgg gagtcggtga taattggtgt gcgtcagggg ccgcatactt tggttactgg      360

ggccagggga cccaggtcac cgtctcctca                                       390


<210>  310
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS80533 sdAb

<400>  310
caggtgcacc tggtggagtc tgggggaggc tcggtgcaga ctggagggtc tctaagactc       60

tcctgtacag cctctggact cagcttcagt acctacacgg tggcctggtt ccgccaggct      120

ccaggaaagg agcgcgaggg ggtcgcggct attccatata ctagtcaaca catggtctat      180

accgactccg tgaagggccg attcaccatc tcccgagaca acacaaagaa catggtgtat      240

ctgcaaatga acagcctgaa accggaggac accgccatgt actactgtgc gacagatcgg      300

cgccctggaa cgagtatgtt ggctataaat gggtataacc gctggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210>  311
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS80444 sdAb

<400>  311
gaggtgcagc tggcggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt cgcaacacga tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcggct attccatata ctagtactgg catagtctat      180

tccgactccg tgggcggccg attcaccatc tcccgagaca acacaaagaa catggtgtat      240

ctgcaaatga acaacctgga accggaggac actgccatgt actactgtgc gacagatcgg      300

cgccctggaa cgactatgtt ggcggtaaat gggtataacc actggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210>  312
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS81487 sdAb

<400>  312
caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagagtc       60

tcctgtttag tctctaaact caccgcatgg cgcagctgcg tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcagct atatattctg gtactggtag tacatactat      180

gccgactccg tgaagggccg attcaccatc gcccaagact acgccaagaa catggtgtac      240

ttgcaaatga acagcctgaa acctgaagac actgccatgt actactgtgc gggcacgtcg      300

atacgcagca gttgtggctt agtgcgcgat gaatacgcct actggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210>  313
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS1 scFv

<400>  313

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 


<210>  314
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 scFv

<400>  314

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
    210                 215                 220                 


Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  315
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  316
<211>  623
<212>  PRT
<213>  Cynomolgus

<400>  316

Met Ala Leu Pro Met Ala Arg Pro Leu Ser Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Val Leu Ala Gly Glu Thr Arg Gln Val Arg Ser Pro Leu 
        35                  40                  45              


Gly Lys Pro Gly Arg Val Phe Ser Leu Ser Pro Arg Gln Leu Leu Gly 
    50                  55                  60                  


Phe Thr Cys Val Glu Val Ser Gly Leu Ser Thr Glu Leu Val Gln Glu 
65                  70                  75                  80  


Leu Ala Val Ala Leu Gly Gln Lys Asn Val Lys Leu Ser Ala Glu Gln 
                85                  90                  95      


Leu Arg Cys Leu Ala His Gln Leu Ser Glu Pro Pro Glu Asp Leu Asp 
            100                 105                 110         


Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro Asp Ala Phe Ser 
        115                 120                 125             


Gly Pro Gln Ala Cys Thr His Phe Phe Ser Arg Val Ala Lys Ala Asn 
    130                 135                 140                 


Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln Arg Leu Leu Pro 
145                 150                 155                 160 


Ala Ala Leu Thr Cys Trp Gly Val Arg Gly Ser Leu Leu Ser Glu Ala 
                165                 170                 175     


Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu Pro Gly Arg Phe 
            180                 185                 190         


Val Ala Glu Ser Ala Glu Val Val Leu Pro Arg Leu Val Arg Cys Leu 
        195                 200                 205             


Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg Ala Ala Leu Gln 
    210                 215                 220                 


Arg Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp Ser Ile Ser Thr 
225                 230                 235                 240 


Leu Asp Asp Leu Gln Ser Leu Leu Pro Val Leu Gly Gln Pro Val Ile 
                245                 250                 255     


His Ser Ile Pro Gln Gly Ile Leu Ala Ala Trp Arg Gln Arg Ser Ser 
            260                 265                 270         


Arg Asp Pro Ser Trp Gln Gln Pro Glu Gln Thr Val Leu Arg Pro Arg 
        275                 280                 285             


Phe Arg Arg Asp Val Glu Arg Thr Thr Cys Pro Pro Glu Lys Glu Val 
    290                 295                 300                 


His Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Arg Glu Leu Glu 
305                 310                 315                 320 


Ala Cys Val Asp Pro Ala Leu Leu Ala Ala Gln Met Asp Arg Val Asp 
                325                 330                 335     


Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu 
            340                 345                 350         


Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val Ile Arg His Leu 
        355                 360                 365             


Gly His Leu Phe Leu Lys Met Ser Pro Glu Asp Ile Arg Lys Trp Asn 
    370                 375                 380                 


Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Lys Val Ser Lys Gly 
385                 390                 395                 400 


His Glu Met Ser Ala Gln Trp Pro Val Pro Gln Val Ala Thr Leu Ile 
                405                 410                 415     


Asp Arg Val Val Val Gly Arg Gly Gln Leu Asp Lys Asp Thr Val Asp 
            420                 425                 430         


Thr Leu Thr Ala Phe Cys Pro Gly Cys Leu Cys Ser Leu Ser Pro Glu 
        435                 440                 445             


Arg Leu Ser Ser Val Pro Pro Ser Val Ile Gly Ala Val Arg Pro Gln 
    450                 455                 460                 


Asp Leu Asp Thr Cys Gly Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys 
465                 470                 475                 480 


Ala Arg Leu Ala Phe Gln Asn Met Ser Gly Ser Glu Tyr Phe Val Lys 
                485                 490                 495     


Ile Arg Pro Phe Leu Gly Gly Ala Pro Thr Glu Asp Val Lys Ala Leu 
            500                 505                 510         


Ser Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg 
        515                 520                 525             


Arg Glu Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu 
    530                 535                 540                 


Gly Pro His Val Glu Gly Leu Lys Val Glu Glu Gln His Ser Pro Val 
545                 550                 555                 560 


Arg Asp Trp Ile Leu Lys Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly 
                565                 570                 575     


Leu Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Ile Leu Asp Leu 
            580                 585                 590         


Ser Val Arg Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly 
        595                 600                 605             


Pro Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620             


<210>  317
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg 
    290                 295 


<210>  318
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  318

Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu Ile 
1               5                   10                  15      


Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val 
            20                  25                  30          


Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro 
        35                  40                  45              


Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu 
    50                  55                  60                  


Tyr Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln His Leu Gly Tyr Leu 
65                  70                  75                  80  


Phe Leu Lys Met Ser Pro Glu Asp Ile Arg Lys Trp Asn Val Thr Ser 
                85                  90                  95      


Leu Glu Thr Leu Lys Ala Leu Leu Glu Val Asn Lys Gly His Glu Met 
            100                 105                 110         


Ser Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly 
        115                 120                 125             


Gln Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly 
    130                 135                 140                 


Tyr Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser 
145                 150                 155                 160 


Ser Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg 
                165                 170                 175     


Gln Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met 
            180                 185                 190         


Asn Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala 
        195                 200                 205             


Pro Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp 
    210                 215                 220                 


Leu Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr 
225                 230                 235                 240 


Val Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys 
                245                 250                 255     


Ala Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg 
            260                 265                 270         


Gln Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro 
        275                 280                 285             


Asn Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly 
    290                 295                 300                 


Thr Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu 
305                 310                 315                 320 


Leu Leu Ala Ser Thr Leu Ala 
                325         


<210>  319
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53

<400>  319

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe 
            20      


<210>  320
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 51-65

<400>  320

Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val Pro Gly Cys 
1               5                   10                  15      


<210>  321
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 81-95

<400>  321

Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys Thr 
1               5                   10                  15  


<210>  322
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 87-94 + FSHbeta 25-42

<400>  322

Cys Asp Ser Asp Ser Thr Asp Cys Ile Leu Gln Cys Met Gly Cys Cys 
1               5                   10                  15      


Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg 
            20                  25      


<210>  323
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 87-94 + FSHbeta 25-42 + FSHbeta 27-45

<400>  323

Cys Asp Ser Asp Ser Thr Asp Cys Ile Leu Gln Cys Met Gly Cys Cys 
1               5                   10                  15      


Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Trp Cys Ala Gly Tyr Cys 
            20                  25                  30          


Tyr Cys Tyr Thr Arg Asp Val Lys Asp Pro Ala Arg Pro 
        35                  40                  45  


<210>  324
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FSHR peptide 33-53

<400>  324

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys 
            


<210>  325
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FSHR peptide 51-65

<400>  325

Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg Val 
1               5                   10                  15  


<210>  326
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FSHR peptide 81-95

<400>  326

Gly Ser Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys 
1               5                   10                  15      


Thr Ala Ser 
            


<210>  327
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FSHR antagonist A

<400>  327

Gly Ser Cys Asp Ser Asp Ser Thr Asp Cys Ile Leu Gln Cys Met Gly 
1               5                   10                  15      


Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ala Ser 
            20                  25                  30  


<210>  328
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FSHR antagonist B

<400>  328

Gly Ser Arg Leu Pro Thr Pro Tyr Ala Arg Ser Phe Cys Cys Gly Met 
1               5                   10                  15      


Cys Gln Leu Ile Cys Asp Thr Ser Asp Ser Asp Cys Ala Ser 
            20                  25                  30  


<210>  329
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FSHR agonist A

<400>  329

Gly Ser Cys Asp Ser Asp Ser Thr Asp Cys Ile Leu Gln Cys Met Gly 
1               5                   10                  15      


Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Trp Cys Ala Gly 
            20                  25                  30          


Tyr Cys Tyr Cys Tyr Thr Arg Asp Leu Val Lys Asp Pro Ala Arg Pro 
        35                  40                  45              


Ala Ser 
    50  


<210>  330
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FSHR agonist B

<400>  330

Pro Arg Ala Pro Asp Lys Val Leu Asp Arg Thr Tyr Cys Tyr Cys Tyr 
1               5                   10                  15      


Gly Ala Cys Trp Arg Leu Pro Thr Pro Tyr Ala Arg Ser Phe Cys Cys 
            20                  25                  30          


Gly Met Cys Gln Leu Ile Cys Asp Thr Ser Asp Ser Asp Cys 
        35                  40                  45      


<210>  331
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-FSHR peptide alpha + beta

<400>  331

Gly Ser Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys 
1               5                   10                  15      


Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly 
            20                  25                  30          


Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
        35                  40                  45              


Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg 
    50                  55                  60                  


Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val 
65                  70                  75                  80  


Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys 
                85                  90                  95      


Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys 
            100                 105                 110         


Glu Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn 
        115                 120                 125             


Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Gly Cys 
    130                 135                 140                 


Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr Met 
145                 150                 155                 160 


Leu Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys Val Ala Lys 
                165                 170                 175     


Ser Tyr Asn Arg Val Thr Val Met Gly Gly Phe Lys Val Glu Asn His 
            180                 185                 190         


Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser Ala Ser 
        195                 200                 205         


<210>  332
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc Fusion FSHbeta 33-53

<400>  332

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            20                  25                  30          


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        35                  40                  45              


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    50                  55                  60                  


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
65                  70                  75                  80  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                85                  90                  95      


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            100                 105                 110         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        115                 120                 125             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    130                 135                 140                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
145                 150                 155                 160 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                165                 170                 175     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            180                 185                 190         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        195                 200                 205             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    210                 215                 220                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
225                 230                 235                 240 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250             


<210>  333
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc Fusion FSHbeta 33-53

<400>  333
tacacccggg acctggtgta taaggatccc gccagaccta agatccagaa gacctgcaca       60

ttcgagccca agtcctgtga taagacccac acatgccccc cttgtcctgc tccagagctg      120

ctgggcggcc ctagcgtgtt cctgtttcca cccaagccta aggacaccct gatgatctct      180

cggaccccag aggtgacatg cgtggtggtg gacgtgagcc acgaggatcc cgaggtgaag      240

tttaactggt atgtggatgg cgtggaggtg cacaatgcca agaccaagcc cagagaggag      300

cagtacaact ccacctatag ggtggtgtct gtgctgacag tgctgcacca ggactggctc      360

aacggcaagg agtataagtg caaggtgtcc aataaggccc tgcccgcccc tatcgagaag      420

accatctcta aggccaaggg ccagcctcgg gagccacagg tgtacacact gcctccatcc      480

agagacgagc tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      540

tctgatatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      600

ccccctgtgc tggactccga tggctctttc tttctgtata gcaagctgac cgtggataag      660

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaggc actgcacaac      720

cattacaccc agaagtcact gtcactgtcc ccaggcaag                             759


<210>  334
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  334

Gly Gly Gly Gly Ser 
1               5   


<210>  335
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  335

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  336
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  336

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  337
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  337

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  338
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  338

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  339
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1alpha promoter

<400>  339
gagtaattca tacaaaagga ctcgcccctg ccttggggaa tcccagggac cgtcgttaaa       60

ctcccactaa cgtagaaccc agagatcgct gcgttcccgc cccctcaccc gcccgctctc      120

gtcatcactg aggtggagaa gagcatgcgt gaggctccgg tgcccgtcag tgggcagagc      180

gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga accggtgcct      240

agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc      300

ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca      360

acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct      420

ttacgggtta tggcccttgc gtgccttgaa ttacttccac gcccctggct gcagtacgtg      480

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      540

ggagcccctt cgcctcgtgc ttgagttgag gcctggcttg ggcgctgggg ccgccgcgtg      600

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      660

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      720

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      780

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg      840

gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc      900

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg      960

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1020

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1080

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1140

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1200

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1260

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1320

tttcaggtgt cgtga                                                      1335


<210>  340
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha signal peptide

<400>  340

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  341
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha hinge domain

<400>  341

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  342
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha transmembrane domain

<400>  342

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  343
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD137 intracellular domain

<400>  343

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  344
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 intracellular domain

<400>  344

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  345
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3alpha intracellular domain

<400>  345

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  346
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A element

<400>  346

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  347
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnTGFbetaRII

<400>  347

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser 
        195                 


<210>  348
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AD58126VH3VL1 scFV tandem

<400>  348

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
        35                  40                  45              


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
    50                  55                  60                  


Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly 
65                  70                  75                  80  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly His Thr Asp Tyr 
                85                  90                  95      


Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr 
            100                 105                 110         


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
        115                 120                 125             


Val Tyr Tyr Cys Ala Arg Ser Asn Trp Ala Trp Phe Pro Tyr Trp Gly 
    130                 135                 140                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
                165                 170                 175     


Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys 
            180                 185                 190         


Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr 
        195                 200                 205             


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp 
    210                 215                 220                 


Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
225                 230                 235                 240 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
                245                 250                 255     


Val Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe 
            260                 265                 270         


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        275                 280     


<210>  349
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS51489 scFV tandem

<400>  349

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        35                  40                  45              


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
    50                  55                  60                  


Leu Tyr Tyr Tyr Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
65                  70                  75                  80  


Leu Glu Trp Val Ala Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Tyr Tyr 
                85                  90                  95      


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
            100                 105                 110         


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        115                 120                 125             


Val Tyr Tyr Cys Ala Arg Tyr Tyr Pro Tyr Tyr Gly Met Asp Tyr Trp 
    130                 135                 140                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
                165                 170                 175     


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
            180                 185                 190         


Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr 
    210                 215                 220                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Gly Phe Ser Tyr Tyr Pro Ile Thr Phe Gly Gln Gly Thr 
            260                 265                 270         


Lys Val Glu Ile Lys 
        275         


<210>  350
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AD92110 scFV tandem

<400>  350

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        35                  40                  45              


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
    50                  55                  60                  


Ile Tyr Tyr Ser Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
65                  70                  75                  80  


Leu Glu Trp Val Ala Tyr Ile Tyr Pro Tyr Tyr Ser Tyr Thr Tyr Tyr 
                85                  90                  95      


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
            100                 105                 110         


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        115                 120                 125             


Val Tyr Tyr Cys Ala Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
                165                 170                 175     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            180                 185                 190         


Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        195                 200                 205             


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val 
    210                 215                 220                 


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
225                 230                 235                 240 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                245                 250                 255     


Ala Ser Ser Gly Tyr His Tyr Leu Ile Thr Phe Gly Gln Gly Thr Lys 
            260                 265                 270         


Val Glu Ile Lys 
        275     


<210>  351
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS91156 scFV tandem

<400>  351

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        35                  40                  45              


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
    50                  55                  60                  


Ile Tyr Ser Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
65                  70                  75                  80  


Leu Glu Trp Val Ala Ser Ile Ser Ser Tyr Ser Ser Tyr Thr Ser Tyr 
                85                  90                  95      


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
            100                 105                 110         


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        115                 120                 125             


Val Tyr Tyr Cys Ala Arg Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
                165                 170                 175     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            180                 185                 190         


Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        195                 200                 205             


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val 
    210                 215                 220                 


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
225                 230                 235                 240 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                245                 250                 255     


Gly Pro Tyr Tyr His Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu 
            260                 265                 270         


Ile Lys 
        


<210>  352
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS91189 scFV tandem

<400>  352

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        35                  40                  45              


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
    50                  55                  60                  


Leu Ser Tyr Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
65                  70                  75                  80  


Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Gly Ser Thr Tyr Tyr 
                85                  90                  95      


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
            100                 105                 110         


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        115                 120                 125             


Val Tyr Tyr Cys Ala Arg Tyr Trp Gly Met Asp Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
                165                 170                 175     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            180                 185                 190         


Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        195                 200                 205             


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val 
    210                 215                 220                 


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
225                 230                 235                 240 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                245                 250                 255     


Tyr Tyr Trp Tyr Tyr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu 
            260                 265                 270         


Ile Lys 
        


<210>  353
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS51674 scFV tandem

<400>  353

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        35                  40                  45              


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
    50                  55                  60                  


Leu Tyr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
65                  70                  75                  80  


Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr Ser Tyr 
                85                  90                  95      


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
            100                 105                 110         


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        115                 120                 125             


Val Tyr Tyr Cys Ala Arg Pro Phe Gly Trp Gly Tyr Ala Gly Met Asp 
    130                 135                 140                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                165                 170                 175     


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
            180                 185                 190         


Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln 
        195                 200                 205             


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
    210                 215                 220                 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
225                 230                 235                 240 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
                245                 250                 255     


Tyr Tyr Cys Gln Gln Gly Tyr Ala Pro Ile Thr Phe Gly Gln Gly Thr 
            260                 265                 270         


Lys Val Glu Ile Lys 
        275         


<210>  354
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS65233 sdAb tandem

<400>  354

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val 
        35                  40                  45              


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr 
    50                  55                  60                  


Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
65                  70                  75                  80  


Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser 
                85                  90                  95      


Val Lys Gly Arg Phe Val Leu Ser Arg Tyr Asn Ala Lys Ser Ile Met 
            100                 105                 110         


Tyr Leu Gln Met Asn Ser Val Lys Leu Glu Asp Thr Ala Met Tyr Tyr 
        115                 120                 125             


Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser 
    130                 135                 140                 


Phe Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
145                 150                 155             


<210>  355
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS60685 sdAb tandem

<400>  355

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
        35                  40                  45              


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Val 
    50                  55                  60                  


Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
65                  70                  75                  80  


Arg Glu Gly Val Ala Ser Met Tyr Val Gly Gly Gly Tyr Thr Tyr Tyr 
                85                  90                  95      


Asp Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
            100                 105                 110         


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
        115                 120                 125             


Met Tyr Tyr Cys Ala Ala Ile Ser Ile Ala Leu Thr Arg Glu Phe Cys 
    130                 135                 140                 


Ala Pro Ile Val Ser Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
145                 150                 155                 160 


Thr Val Ser Ser 
                


<210>  356
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS60702 sdAb tandem

<400>  356

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val 
        35                  40                  45              


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Val 
    50                  55                  60                  


Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
65                  70                  75                  80  


Arg Glu Gly Val Ala Ser Ile Tyr Val Gly Gly Gly Tyr Thr Asn Tyr 
                85                  90                  95      


Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys 
            100                 105                 110         


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
        115                 120                 125             


Met Tyr Tyr Cys Ala Ala Ile Thr Val Ala Leu Thr Arg Ala Phe Cys 
    130                 135                 140                 


Ala Pro Ile Pro Ser Arg Tyr Thr Asn Trp Gly Gln Gly Thr Gln Val 
145                 150                 155                 160 


Thr Val Ser Ser 
                


<210>  357
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS60676 sdAb tandem

<400>  357

Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
1               5                   10                  15      


Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
        35                  40                  45              


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr 
    50                  55                  60                  


Val Ser Ser Gly Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
65                  70                  75                  80  


Arg Glu Arg Val Ala Gln Ile Gly Arg Asp Ala Thr Thr Thr Tyr Ala 
                85                  90                  95      


Asp Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asp Ala Glu Asn 
            100                 105                 110         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met 
        115                 120                 125             


Tyr Ser Cys Thr Ala Tyr Trp Gly Val Tyr Cys Leu Ser Pro Gly Arg 
    130                 135                 140                 


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
145                 150                 155     


<210>  358
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126VH3VL1 CAR

<400>  358

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly His Thr Asp 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Ala Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Asn Trp Ala Trp Phe Pro Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
145                 150                 155                 160 


Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys 
                165                 170                 175     


Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
            180                 185                 190         


Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
225                 230                 235                 240 


Asp Val Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  359
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489 CAR

<400>  359

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Tyr Tyr Tyr Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Pro Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu 
        195                 200                 205             


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Gly Phe Ser Tyr Tyr Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  360
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110 CAR

<400>  360

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Tyr Tyr Ser Ser Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Tyr Ile Tyr Pro Tyr Tyr Ser Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Ala Ser Ser Gly Tyr His Tyr Leu Ile Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                325                 330                 335     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            340                 345                 350         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        355                 360                 365             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg 
                


<210>  361
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156 CAR

<400>  361

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Tyr Ser Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Ser Ser Tyr Ser Ser Tyr Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Gly Pro Tyr Tyr His Pro Ile Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  362
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189 CAR

<400>  362

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Ser Tyr Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Trp Gly Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Tyr Tyr Trp Tyr Tyr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  363
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674 CAR

<400>  363

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Tyr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Pro Phe Gly Trp Gly Tyr Ala Gly Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
        195                 200                 205             


Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Gly Tyr Ala Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  364
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233 CAR

<400>  364

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val His Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe 
        35                  40                  45              


Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
    50                  55                  60                  


Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Val Leu Ser Arg Tyr Asn Ala Lys Ser Ile 
                85                  90                  95      


Met Tyr Leu Gln Met Asn Ser Val Lys Leu Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser 
        115                 120                 125             


Ser Phe Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365     


<210>  365
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60685 CAR

<400>  365

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ser Met Tyr Val Gly Gly Gly Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Asp Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ile Ser Ile Ala Leu Thr Arg Glu Phe 
        115                 120                 125             


Cys Ala Pro Ile Val Ser Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                165                 170                 175     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        195                 200                 205             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg 
    370         


<210>  366
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60702 CAR

<400>  366

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ser Ile Tyr Val Gly Gly Gly Tyr Thr Asn 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ile Thr Val Ala Leu Thr Arg Ala Phe 
        115                 120                 125             


Cys Ala Pro Ile Pro Ser Arg Tyr Thr Asn Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                165                 170                 175     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        195                 200                 205             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg 
    370         


<210>  367
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60676 CAR

<400>  367

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Thr Val Ser Ser Gly Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Arg Val Ala Gln Ile Gly Arg Asp Ala Thr Thr Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asp Ala Glu 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Ser Cys Thr Ala Tyr Trp Gly Val Tyr Cys Leu Ser Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr 
    130                 135                 140                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
145                 150                 155                 160 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                165                 170                 175     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            180                 185                 190         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        195                 200                 205             


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    210                 215                 220                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
225                 230                 235                 240 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                245                 250                 255     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
            260                 265                 270         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        275                 280                 285             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    290                 295                 300                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
305                 310                 315                 320 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                325                 330                 335     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            340                 345                 350         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 


<210>  368
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SS1 CAR

<400>  368

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Glu Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
    50                  55                  60                  


Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                165                 170                 175     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        195                 200                 205             


Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Trp Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  369
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 CAR

<400>  369

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn 
65                  70                  75                  80  


Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser 
        195                 200                 205             


Ile Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210>  370
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AD58126VH3VL1 tandem CAR

<400>  370

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
    50                  55                  60                  


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
65                  70                  75                  80  


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln 
                85                  90                  95      


Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr 
            100                 105                 110         


Gly His Thr Asp Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr 
        115                 120                 125             


Ala Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg 
    130                 135                 140                 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asn Trp Ala Trp 
145                 150                 155                 160 


Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
            180                 185                 190         


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
        195                 200                 205             


Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln 
    210                 215                 220                 


Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
225                 230                 235                 240 


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg 
                245                 250                 255     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            260                 265                 270         


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser 
        275                 280                 285             


Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr 
    290                 295                 300                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
305                 310                 315                 320 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                325                 330                 335     


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
            340                 345                 350         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        355                 360                 365             


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
    370                 375                 380                 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
385                 390                 395                 400 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
                405                 410                 415     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
            420                 425                 430         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        435                 440                 445             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    450                 455                 460                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
465                 470                 475                 480 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                485                 490                 495     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            500                 505                 510         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520                 525 


<210>  371
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS51489 tandem CAR

<400>  371

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr Ser Ile His Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Ser Ser 
            100                 105                 110         


Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Pro Tyr Tyr 
145                 150                 155                 160 


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
            180                 185                 190         


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
        195                 200                 205             


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
    210                 215                 220                 


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser 
225                 230                 235                 240 


Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg 
                245                 250                 255     


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
            260                 265                 270         


Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Tyr Tyr Pro Ile Thr 
        275                 280                 285             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro 
    290                 295                 300                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
305                 310                 315                 320 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                325                 330                 335     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            340                 345                 350         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        355                 360                 365             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    370                 375                 380                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
385                 390                 395                 400 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    450                 455                 460                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
465                 470                 475                 480 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                485                 490                 495     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            500                 505                 510         


Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520     


<210>  372
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS92110 tandem CAR

<400>  372

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Asn Ile Tyr Tyr Ser Ser Met His Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Tyr Pro Tyr Tyr 
            100                 105                 110         


Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ala Leu Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
            180                 185                 190         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        195                 200                 205             


Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln 
    210                 215                 220                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                245                 250                 255     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            260                 265                 270         


Tyr Tyr Cys Gln Gln Ala Ser Ser Gly Tyr His Tyr Leu Ile Thr Phe 
        275                 280                 285             


Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
    290                 295                 300                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
305                 310                 315                 320 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                325                 330                 335     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            340                 345                 350         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
        355                 360                 365             


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    370                 375                 380                 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
385                 390                 395                 400 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            500                 505                 510         


His Met Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  373
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS91156 tandem CAR

<400>  373

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Asn Ile Tyr Ser Ser Ser Ile His Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Ser Ser Tyr Ser 
            100                 105                 110         


Ser Tyr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Ala Met Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
            180                 185                 190         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        195                 200                 205             


Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln 
    210                 215                 220                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                245                 250                 255     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            260                 265                 270         


Tyr Tyr Cys Gln Gln Gly Pro Tyr Tyr His Pro Ile Thr Phe Gly Gln 
        275                 280                 285             


Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    290                 295                 300                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
305                 310                 315                 320 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                325                 330                 335     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            340                 345                 350         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
        355                 360                 365             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    370                 375                 380                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
385                 390                 395                 400 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                405                 410                 415     


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            420                 425                 430         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        435                 440                 445             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    450                 455                 460                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
465                 470                 475                 480 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                485                 490                 495     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            500                 505                 510         


Gln Ala Leu Pro Pro Arg 
        515             


<210>  374
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS91189 tandem CAR

<400>  374

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Asn Leu Ser Tyr Ser Ser Ile His Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser 
            100                 105                 110         


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Trp Gly Met Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
            180                 185                 190         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        195                 200                 205             


Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln 
    210                 215                 220                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                245                 250                 255     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            260                 265                 270         


Tyr Tyr Cys Gln Gln Tyr Tyr Trp Tyr Tyr Pro Ile Thr Phe Gly Gln 
        275                 280                 285             


Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    290                 295                 300                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
305                 310                 315                 320 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                325                 330                 335     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            340                 345                 350         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
        355                 360                 365             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    370                 375                 380                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
385                 390                 395                 400 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                405                 410                 415     


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            420                 425                 430         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        435                 440                 445             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    450                 455                 460                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
465                 470                 475                 480 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                485                 490                 495     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            500                 505                 510         


Gln Ala Leu Pro Pro Arg 
        515             


<210>  375
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS51674 tandem CAR

<400>  375

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Asn Leu Tyr Ser Tyr Tyr Met His Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser 
            100                 105                 110         


Ser Tyr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Phe Gly Trp Gly 
145                 150                 155                 160 


Tyr Ala Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185                 190         


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
        195                 200                 205             


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
    210                 215                 220                 


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
225                 230                 235                 240 


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
                245                 250                 255     


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
            260                 265                 270         


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ala Pro Ile Thr 
        275                 280                 285             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro 
    290                 295                 300                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
305                 310                 315                 320 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                325                 330                 335     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            340                 345                 350         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        355                 360                 365             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    370                 375                 380                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
385                 390                 395                 400 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    450                 455                 460                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
465                 470                 475                 480 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                485                 490                 495     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            500                 505                 510         


Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520     


<210>  376
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS65233 tandem CAR

<400>  376

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val His Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Glu Phe Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Glu Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr 
            100                 105                 110         


Val Tyr Ala Asp Ser Val Lys Gly Arg Phe Val Leu Ser Arg Tyr Asn 
        115                 120                 125             


Ala Lys Ser Ile Met Tyr Leu Gln Met Asn Ser Val Lys Leu Glu Asp 
    130                 135                 140                 


Thr Ala Met Tyr Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp 
145                 150                 155                 160 


Ser Ser Pro Ser Ser Phe Asp Phe Trp Gly Gln Gly Thr Gln Val Thr 
                165                 170                 175     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            180                 185                 190         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        195                 200                 205             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    210                 215                 220                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
225                 230                 235                 240 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                245                 250                 255     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            260                 265                 270         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        275                 280                 285             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    290                 295                 300                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
305                 310                 315                 320 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                325                 330                 335     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            340                 345                 350         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        355                 360                 365             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    370                 375                 380                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
385                 390                 395                 400 


Pro Arg 
        


<210>  377
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS60685 tandem CAR

<400>  377

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Asn Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ser Met Tyr Val Gly Gly 
            100                 105                 110         


Gly Tyr Thr Tyr Tyr Asp Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys 
    130                 135                 140                 


Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ile Ser Ile Ala Leu 
145                 150                 155                 160 


Thr Arg Glu Phe Cys Ala Pro Ile Val Ser Arg Tyr Asn Tyr Trp Gly 
                165                 170                 175     


Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            180                 185                 190         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        195                 200                 205             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    210                 215                 220                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
225                 230                 235                 240 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                245                 250                 255     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            260                 265                 270         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        275                 280                 285             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    290                 295                 300                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
305                 310                 315                 320 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                325                 330                 335     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            340                 345                 350         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        355                 360                 365             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    370                 375                 380                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
385                 390                 395                 400 


His Met Gln Ala Leu Pro Pro Arg 
                405             


<210>  378
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS60702 tandem CAR

<400>  378

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Asn Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ser Ile Tyr Val Gly Gly 
            100                 105                 110         


Gly Tyr Thr Asn Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys 
    130                 135                 140                 


Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ile Thr Val Ala Leu 
145                 150                 155                 160 


Thr Arg Ala Phe Cys Ala Pro Ile Pro Ser Arg Tyr Thr Asn Trp Gly 
                165                 170                 175     


Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            180                 185                 190         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        195                 200                 205             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    210                 215                 220                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
225                 230                 235                 240 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                245                 250                 255     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            260                 265                 270         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        275                 280                 285             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    290                 295                 300                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
305                 310                 315                 320 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                325                 330                 335     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            340                 345                 350         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        355                 360                 365             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    370                 375                 380                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
385                 390                 395                 400 


His Met Gln Ala Leu Pro Pro Arg 
                405             


<210>  379
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS60676 tandem CAR

<400>  379

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Tyr Thr Val Ser Ser Gly Cys Met Gly Trp Phe Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Glu Arg Glu Arg Val Ala Gln Ile Gly Arg Asp Ala 
            100                 105                 110         


Thr Thr Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ala Arg 
        115                 120                 125             


Asp Asp Ala Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    130                 135                 140                 


Glu Asp Thr Ala Met Tyr Ser Cys Thr Ala Tyr Trp Gly Val Tyr Cys 
145                 150                 155                 160 


Leu Ser Pro Gly Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                165                 170                 175     


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            180                 185                 190         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
        195                 200                 205             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
    210                 215                 220                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                245                 250                 255     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            260                 265                 270         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        275                 280                 285             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
    290                 295                 300                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
305                 310                 315                 320 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                325                 330                 335     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            340                 345                 350         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        355                 360                 365             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    370                 375                 380                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 395                 400 


<210>  380
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126VH3VL1 + FSHbeta 33-53 dual CAR

<400>  380

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly His Thr Asp 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Ala Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Asn Trp Ala Trp Phe Pro Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
145                 150                 155                 160 


Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys 
                165                 170                 175     


Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
            180                 185                 190         


Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
225                 230                 235                 240 


Asp Val Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe 
                485                 490                 495     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
        515                 520                 525             


Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg 
    530                 535                 540                 


Pro Lys Ile Gln Lys Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg 
545                 550                 555                 560 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
                565                 570                 575     


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
            580                 585                 590         


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
        595                 600                 605             


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
    610                 615                 620                 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
625                 630                 635                 640 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
                645                 650                 655     


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
            660                 665                 670         


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        675                 680                 685             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    690                 695                 700                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
705                 710                 715                 720 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                725                 730                 735     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            740                 745                 750         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        755                 760                 765             


Met Gln Ala Leu Pro Pro Arg 
    770                 775 


<210>  381
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489 + FSHbeta 33-53 dual CAR

<400>  381

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Tyr Tyr Tyr Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Pro Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu 
        195                 200                 205             


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Gly Phe Ser Tyr Tyr Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            500                 505                 510         


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        515                 520                 525             


Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
    530                 535                 540                 


Lys Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
545                 550                 555                 560 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                565                 570                 575     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            580                 585                 590         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        595                 600                 605             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
    610                 615                 620                 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
625                 630                 635                 640 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
                645                 650                 655     


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            660                 665                 670         


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        675                 680                 685             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    690                 695                 700                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
705                 710                 715                 720 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                725                 730                 735     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            740                 745                 750         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        755                 760                 765             


Pro Pro Arg 
    770     


<210>  382
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110 + FSHbeta 33-53 dual CAR

<400>  382

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Tyr Tyr Ser Ser Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Tyr Ile Tyr Pro Tyr Tyr Ser Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Ala Ser Ser Gly Tyr His Tyr Leu Ile Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                325                 330                 335     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            340                 345                 350         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        355                 360                 365             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                485                 490                 495     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr 
            500                 505                 510         


Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr 
        515                 520                 525             


Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys 
    530                 535                 540                 


Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
545                 550                 555                 560 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
                565                 570                 575     


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
            580                 585                 590         


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
        595                 600                 605             


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
    610                 615                 620                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
625                 630                 635                 640 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                645                 650                 655     


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
            660                 665                 670         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        675                 680                 685             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    690                 695                 700                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
705                 710                 715                 720 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                725                 730                 735     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            740                 745                 750         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        755                 760                 765             


Pro Arg 
    770 


<210>  383
<211>  768
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156 + FSHbeta 33-53 dual CAR

<400>  383

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Tyr Ser Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Ser Ser Tyr Ser Ser Tyr Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Gly Pro Tyr Tyr His Pro Ile Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu 
            500                 505                 510         


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg 
        515                 520                 525             


Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys 
    530                 535                 540                 


Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
545                 550                 555                 560 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                565                 570                 575     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            580                 585                 590         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        595                 600                 605             


Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
    610                 615                 620                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
625                 630                 635                 640 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                645                 650                 655     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            660                 665                 670         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        675                 680                 685             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    690                 695                 700                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
705                 710                 715                 720 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                725                 730                 735     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            740                 745                 750         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760                 765             


<210>  384
<211>  768
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189 + FSHbeta 33-53 dual CAR

<400>  384

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Ser Tyr Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Trp Gly Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Tyr Tyr Trp Tyr Tyr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu 
            500                 505                 510         


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg 
        515                 520                 525             


Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys 
    530                 535                 540                 


Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
545                 550                 555                 560 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                565                 570                 575     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            580                 585                 590         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        595                 600                 605             


Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
    610                 615                 620                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
625                 630                 635                 640 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                645                 650                 655     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            660                 665                 670         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        675                 680                 685             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    690                 695                 700                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
705                 710                 715                 720 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                725                 730                 735     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            740                 745                 750         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760                 765             


<210>  385
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674 + FSHbeta 33-53 dual CAR

<400>  385

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Tyr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Pro Phe Gly Trp Gly Tyr Ala Gly Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
        195                 200                 205             


Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Gly Tyr Ala Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            500                 505                 510         


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        515                 520                 525             


Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
    530                 535                 540                 


Lys Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
545                 550                 555                 560 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                565                 570                 575     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            580                 585                 590         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        595                 600                 605             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
    610                 615                 620                 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
625                 630                 635                 640 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
                645                 650                 655     


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            660                 665                 670         


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        675                 680                 685             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    690                 695                 700                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
705                 710                 715                 720 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                725                 730                 735     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            740                 745                 750         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        755                 760                 765             


Pro Pro Arg 
    770     


<210>  386
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233 + FSHbeta 33-53 dual CAR

<400>  386

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val His Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe 
        35                  40                  45              


Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
    50                  55                  60                  


Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Val Leu Ser Arg Tyr Asn Ala Lys Ser Ile 
                85                  90                  95      


Met Tyr Leu Gln Met Asn Ser Val Lys Leu Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser 
        115                 120                 125             


Ser Phe Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
        355                 360                 365             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    370                 375                 380                 


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
385                 390                 395                 400 


Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr 
                405                 410                 415     


Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Thr Thr 
            420                 425                 430         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        435                 440                 445             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    450                 455                 460                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
465                 470                 475                 480 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490                 495     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            500                 505                 510         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        515                 520                 525             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    530                 535                 540                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
545                 550                 555                 560 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                565                 570                 575     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            580                 585                 590         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        595                 600                 605             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    610                 615                 620                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
625                 630                 635                 640 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                645                 650         


<210>  387
<211>  658
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60685 + FSHbeta 33-53 dual CAR

<400>  387

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ser Met Tyr Val Gly Gly Gly Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Asp Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ile Ser Ile Ala Leu Thr Arg Glu Phe 
        115                 120                 125             


Cys Ala Pro Ile Val Ser Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                165                 170                 175     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        195                 200                 205             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    370                 375                 380                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr 
385                 390                 395                 400 


Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr 
                405                 410                 415     


Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys 
            420                 425                 430         


Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        435                 440                 445             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    450                 455                 460                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
465                 470                 475                 480 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                485                 490                 495     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
            500                 505                 510         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        515                 520                 525             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    530                 535                 540                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
545                 550                 555                 560 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                565                 570                 575     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            580                 585                 590         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        595                 600                 605             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    610                 615                 620                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
625                 630                 635                 640 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                645                 650                 655     


Pro Arg 
        


<210>  388
<211>  658
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60702 + FSHbeta 33-53 dual CAR

<400>  388

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ser Ile Tyr Val Gly Gly Gly Tyr Thr Asn 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ile Thr Val Ala Leu Thr Arg Ala Phe 
        115                 120                 125             


Cys Ala Pro Ile Pro Ser Arg Tyr Thr Asn Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                165                 170                 175     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        195                 200                 205             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    370                 375                 380                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr 
385                 390                 395                 400 


Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr 
                405                 410                 415     


Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys 
            420                 425                 430         


Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        435                 440                 445             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    450                 455                 460                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
465                 470                 475                 480 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                485                 490                 495     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
            500                 505                 510         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        515                 520                 525             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    530                 535                 540                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
545                 550                 555                 560 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                565                 570                 575     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            580                 585                 590         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        595                 600                 605             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    610                 615                 620                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
625                 630                 635                 640 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                645                 650                 655     


Pro Arg 
        


<210>  389
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60676 + FSHbeta 33-53 dual CAR

<400>  389

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Thr Val Ser Ser Gly Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Arg Val Ala Gln Ile Gly Arg Asp Ala Thr Thr Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asp Ala Glu 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Ser Cys Thr Ala Tyr Trp Gly Val Tyr Cys Leu Ser Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr 
    130                 135                 140                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
145                 150                 155                 160 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                165                 170                 175     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            180                 185                 190         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        195                 200                 205             


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    210                 215                 220                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
225                 230                 235                 240 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                245                 250                 255     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
            260                 265                 270         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        275                 280                 285             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    290                 295                 300                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
305                 310                 315                 320 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                325                 330                 335     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            340                 345                 350         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
        355                 360                 365             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    370                 375                 380                 


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
385                 390                 395                 400 


Leu Leu His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp 
                405                 410                 415     


Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Thr Thr Thr Pro 
            420                 425                 430         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        435                 440                 445             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    450                 455                 460                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
465                 470                 475                 480 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                485                 490                 495     


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            500                 505                 510         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        515                 520                 525             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
    530                 535                 540                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
545                 550                 555                 560 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                565                 570                 575     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            580                 585                 590         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        595                 600                 605             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    610                 615                 620                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
625                 630                 635                 640 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                645                 650 


<210>  390
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126VH3VL1 CAR with dnTGFbetaRII

<400>  390

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly His Thr Asp 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Ala Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Asn Trp Ala Trp Phe Pro Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
145                 150                 155                 160 


Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys 
                165                 170                 175     


Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
            180                 185                 190         


Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
225                 230                 235                 240 


Asp Val Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe 
                485                 490                 495     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp 
        515                 520                 525             


Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn 
    530                 535                 540                 


Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln 
545                 550                 555                 560 


Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys 
                565                 570                 575     


Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln 
            580                 585                 590         


Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu 
        595                 600                 605             


Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu 
    610                 615                 620                 


Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro 
625                 630                 635                 640 


Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp 
                645                 650                 655     


Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu 
            660                 665                 670         


Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly 
        675                 680                 685             


Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg 
    690                 695                 700                 


Gln Gln Lys Leu Ser Ser 
705                 710 


<210>  391
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489 CAR with dnTGFbetaRII

<400>  391

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Tyr Tyr Tyr Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Pro Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu 
        195                 200                 205             


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Gly Phe Ser Tyr Tyr Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu 
            500                 505                 510         


Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala 
        515                 520                 525             


Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
    530                 535                 540                 


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
545                 550                 555                 560 


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
                565                 570                 575     


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
            580                 585                 590         


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
        595                 600                 605             


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
    610                 615                 620                 


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
625                 630                 635                 640 


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
                645                 650                 655     


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe 
            660                 665                 670         


Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser 
        675                 680                 685             


Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu 
    690                 695                 700                 


Ser Ser 
705     


<210>  392
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110 CAR with dnTGFbetaRII

<400>  392

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Tyr Tyr Ser Ser Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Tyr Ile Tyr Pro Tyr Tyr Ser Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Ala Ser Ser Gly Tyr His Tyr Leu Ile Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                325                 330                 335     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            340                 345                 350         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        355                 360                 365             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                485                 490                 495     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu 
            500                 505                 510         


Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser 
        515                 520                 525             


Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
    530                 535                 540                 


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
545                 550                 555                 560 


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
                565                 570                 575     


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
            580                 585                 590         


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
        595                 600                 605             


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
    610                 615                 620                 


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
625                 630                 635                 640 


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
                645                 650                 655     


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
            660                 665                 670         


Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val 
        675                 680                 685             


Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser 
    690                 695                 700                 


Ser 
705 


<210>  393
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156 CAR with dnTGFbetaRII

<400>  393

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Tyr Ser Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Ser Ser Tyr Ser Ser Tyr Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Gly Pro Tyr Tyr His Pro Ile Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly 
            500                 505                 510         


Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile 
        515                 520                 525             


Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp 
    530                 535                 540                 


Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val 
545                 550                 555                 560 


Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser 
                565                 570                 575     


Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp 
            580                 585                 590         


Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro 
        595                 600                 605             


Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys 
    610                 615                 620                 


Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys 
625                 630                 635                 640 


Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu 
                645                 650                 655     


Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr 
            660                 665                 670         


Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile 
        675                 680                 685             


Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    690                 695                 700             


<210>  394
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189 CAR with dnTGFbetaRII

<400>  394

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Ser Tyr Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Trp Gly Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Tyr Tyr Trp Tyr Tyr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly 
            500                 505                 510         


Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile 
        515                 520                 525             


Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp 
    530                 535                 540                 


Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val 
545                 550                 555                 560 


Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser 
                565                 570                 575     


Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp 
            580                 585                 590         


Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro 
        595                 600                 605             


Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys 
    610                 615                 620                 


Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys 
625                 630                 635                 640 


Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu 
                645                 650                 655     


Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr 
            660                 665                 670         


Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile 
        675                 680                 685             


Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    690                 695                 700             


<210>  395
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674 CAR with dnTGFbetaRII

<400>  395

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Tyr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Pro Phe Gly Trp Gly Tyr Ala Gly Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
        195                 200                 205             


Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Gly Tyr Ala Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu 
            500                 505                 510         


Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala 
        515                 520                 525             


Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
    530                 535                 540                 


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
545                 550                 555                 560 


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
                565                 570                 575     


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
            580                 585                 590         


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
        595                 600                 605             


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
    610                 615                 620                 


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
625                 630                 635                 640 


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
                645                 650                 655     


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe 
            660                 665                 670         


Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser 
        675                 680                 685             


Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu 
    690                 695                 700                 


Ser Ser 
705     


<210>  396
<211>  587
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233 CAR with dnTGFbetaRII

<400>  396

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val His Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe 
        35                  40                  45              


Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
    50                  55                  60                  


Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Val Leu Ser Arg Tyr Asn Ala Lys Ser Ile 
                85                  90                  95      


Met Tyr Leu Gln Met Asn Ser Val Lys Leu Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser 
        115                 120                 125             


Ser Phe Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
        355                 360                 365             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    370                 375                 380                 


Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu 
385                 390                 395                 400 


His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val 
                405                 410                 415     


Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala 
            420                 425                 430         


Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr 
        435                 440                 445             


Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile 
    450                 455                 460                 


Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp 
465                 470                 475                 480 


Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr 
                485                 490                 495     


His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys 
            500                 505                 510         


Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser 
        515                 520                 525             


Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser 
    530                 535                 540                 


Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu 
545                 550                 555                 560 


Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys 
                565                 570                 575     


Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
            580                 585         


<210>  397
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60685 CAR with dnTGFbetaRII

<400>  397

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ser Met Tyr Val Gly Gly Gly Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Asp Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ile Ser Ile Ala Leu Thr Arg Glu Phe 
        115                 120                 125             


Cys Ala Pro Ile Val Ser Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                165                 170                 175     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        195                 200                 205             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    370                 375                 380                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu 
385                 390                 395                 400 


Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser 
                405                 410                 415     


Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
            420                 425                 430         


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
        435                 440                 445             


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
    450                 455                 460                 


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
465                 470                 475                 480 


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
                485                 490                 495     


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
            500                 505                 510         


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
        515                 520                 525             


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
    530                 535                 540                 


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
545                 550                 555                 560 


Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val 
                565                 570                 575     


Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser 
            580                 585                 590         


Ser 
    


<210>  398
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60702 CAR with dnTGFbetaRII

<400>  398

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ser Ile Tyr Val Gly Gly Gly Tyr Thr Asn 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ile Thr Val Ala Leu Thr Arg Ala Phe 
        115                 120                 125             


Cys Ala Pro Ile Pro Ser Arg Tyr Thr Asn Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                165                 170                 175     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        195                 200                 205             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    370                 375                 380                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu 
385                 390                 395                 400 


Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser 
                405                 410                 415     


Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
            420                 425                 430         


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
        435                 440                 445             


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
    450                 455                 460                 


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
465                 470                 475                 480 


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
                485                 490                 495     


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
            500                 505                 510         


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
        515                 520                 525             


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
    530                 535                 540                 


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
545                 550                 555                 560 


Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val 
                565                 570                 575     


Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser 
            580                 585                 590         


Ser 
    


<210>  399
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60676 CAR with dnTGFbetaRII

<400>  399

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Thr Val Ser Ser Gly Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Arg Val Ala Gln Ile Gly Arg Asp Ala Thr Thr Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asp Ala Glu 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Ser Cys Thr Ala Tyr Trp Gly Val Tyr Cys Leu Ser Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr 
    130                 135                 140                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
145                 150                 155                 160 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                165                 170                 175     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            180                 185                 190         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        195                 200                 205             


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    210                 215                 220                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
225                 230                 235                 240 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                245                 250                 255     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
            260                 265                 270         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        275                 280                 285             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    290                 295                 300                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
305                 310                 315                 320 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                325                 330                 335     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            340                 345                 350         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
        355                 360                 365             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    370                 375                 380                 


Gly Pro Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile 
385                 390                 395                 400 


Val Leu Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys 
                405                 410                 415     


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
            420                 425                 430         


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
        435                 440                 445             


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
    450                 455                 460                 


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
465                 470                 475                 480 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
                485                 490                 495     


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
            500                 505                 510         


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
        515                 520                 525             


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
    530                 535                 540                 


Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro 
545                 550                 555                 560 


Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg 
                565                 570                 575     


Val Asn Arg Gln Gln Lys Leu Ser Ser 
            580                 585 


<210>  400
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AD58126VH3VL1 tandem CAR with dnTGFbetaRII

<400>  400

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
    50                  55                  60                  


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
65                  70                  75                  80  


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln 
                85                  90                  95      


Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr 
            100                 105                 110         


Gly His Thr Asp Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr 
        115                 120                 125             


Ala Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg 
    130                 135                 140                 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asn Trp Ala Trp 
145                 150                 155                 160 


Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
            180                 185                 190         


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
        195                 200                 205             


Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln 
    210                 215                 220                 


Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
225                 230                 235                 240 


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg 
                245                 250                 255     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            260                 265                 270         


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser 
        275                 280                 285             


Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr 
    290                 295                 300                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
305                 310                 315                 320 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                325                 330                 335     


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
            340                 345                 350         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        355                 360                 365             


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
    370                 375                 380                 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
385                 390                 395                 400 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
                405                 410                 415     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
            420                 425                 430         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        435                 440                 445             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    450                 455                 460                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
465                 470                 475                 480 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                485                 490                 495     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            500                 505                 510         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
        515                 520                 525             


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
    530                 535                 540                 


Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His 
545                 550                 555                 560 


Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln 
                565                 570                 575     


Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
            580                 585                 590         


Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys 
        595                 600                 605             


Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys 
    610                 615                 620                 


Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu 
625                 630                 635                 640 


Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His 
                645                 650                 655     


Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu 
            660                 665                 670         


Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp 
        675                 680                 685             


Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn 
    690                 695                 700                 


Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu 
705                 710                 715                 720 


Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr 
                725                 730                 735     


Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
            740                 745     


<210>  401
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS51489 tandem CAR with dnTGFbetaRII

<400>  401

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr Ser Ile His Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Ser Ser 
            100                 105                 110         


Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Pro Tyr Tyr 
145                 150                 155                 160 


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
            180                 185                 190         


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
        195                 200                 205             


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
    210                 215                 220                 


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser 
225                 230                 235                 240 


Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg 
                245                 250                 255     


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
            260                 265                 270         


Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Tyr Tyr Pro Ile Thr 
        275                 280                 285             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro 
    290                 295                 300                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
305                 310                 315                 320 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                325                 330                 335     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            340                 345                 350         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        355                 360                 365             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    370                 375                 380                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
385                 390                 395                 400 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    450                 455                 460                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
465                 470                 475                 480 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                485                 490                 495     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            500                 505                 510         


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe 
        515                 520                 525             


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
    530                 535                 540                 


Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp 
545                 550                 555                 560 


Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn 
                565                 570                 575     


Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln 
            580                 585                 590         


Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys 
        595                 600                 605             


Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln 
    610                 615                 620                 


Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu 
625                 630                 635                 640 


Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu 
                645                 650                 655     


Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro 
            660                 665                 670         


Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp 
        675                 680                 685             


Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu 
    690                 695                 700                 


Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly 
705                 710                 715                 720 


Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg 
                725                 730                 735     


Gln Gln Lys Leu Ser Ser 
            740         


<210>  402
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS92110 tandem CAR with dnTGFbetaRII

<400>  402

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Asn Ile Tyr Tyr Ser Ser Met His Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Tyr Pro Tyr Tyr 
            100                 105                 110         


Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ala Leu Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
            180                 185                 190         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        195                 200                 205             


Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln 
    210                 215                 220                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                245                 250                 255     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            260                 265                 270         


Tyr Tyr Cys Gln Gln Ala Ser Ser Gly Tyr His Tyr Leu Ile Thr Phe 
        275                 280                 285             


Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
    290                 295                 300                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
305                 310                 315                 320 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                325                 330                 335     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            340                 345                 350         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
        355                 360                 365             


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    370                 375                 380                 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
385                 390                 395                 400 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            500                 505                 510         


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
        515                 520                 525             


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly 
    530                 535                 540                 


Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr 
545                 550                 555                 560 


Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn 
                565                 570                 575     


Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu 
            580                 585                 590         


Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser 
        595                 600                 605             


Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu 
    610                 615                 620                 


Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu 
625                 630                 635                 640 


Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu 
                645                 650                 655     


Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly 
            660                 665                 670         


Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn 
        675                 680                 685             


Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu 
    690                 695                 700                 


Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val 
705                 710                 715                 720 


Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln 
                725                 730                 735     


Gln Lys Leu Ser Ser 
            740     


<210>  403
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS91156 tandem CAR with dnTGFbetaRII

<400>  403

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Asn Ile Tyr Ser Ser Ser Ile His Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Ser Ser Tyr Ser 
            100                 105                 110         


Ser Tyr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Ala Met Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
            180                 185                 190         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        195                 200                 205             


Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln 
    210                 215                 220                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                245                 250                 255     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            260                 265                 270         


Tyr Tyr Cys Gln Gln Gly Pro Tyr Tyr His Pro Ile Thr Phe Gly Gln 
        275                 280                 285             


Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    290                 295                 300                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
305                 310                 315                 320 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                325                 330                 335     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            340                 345                 350         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
        355                 360                 365             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    370                 375                 380                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
385                 390                 395                 400 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                405                 410                 415     


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            420                 425                 430         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        435                 440                 445             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    450                 455                 460                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
465                 470                 475                 480 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                485                 490                 495     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            500                 505                 510         


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        515                 520                 525             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly 
    530                 535                 540                 


Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile 
545                 550                 555                 560 


Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met 
                565                 570                 575     


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys 
            580                 585                 590         


Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met 
        595                 600                 605             


Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys 
    610                 615                 620                 


Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val 
625                 630                 635                 640 


Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala 
                645                 650                 655     


Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr 
            660                 665                 670         


Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile 
        675                 680                 685             


Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile 
    690                 695                 700                 


Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile 
705                 710                 715                 720 


Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys 
                725                 730                 735     


Leu Ser Ser 
            


<210>  404
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS91189 tandem CAR with dnTGFbetaRII

<400>  404

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Asn Leu Ser Tyr Ser Ser Ile His Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser 
            100                 105                 110         


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Trp Gly Met Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
            180                 185                 190         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        195                 200                 205             


Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln 
    210                 215                 220                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                245                 250                 255     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            260                 265                 270         


Tyr Tyr Cys Gln Gln Tyr Tyr Trp Tyr Tyr Pro Ile Thr Phe Gly Gln 
        275                 280                 285             


Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    290                 295                 300                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
305                 310                 315                 320 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                325                 330                 335     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            340                 345                 350         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
        355                 360                 365             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    370                 375                 380                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
385                 390                 395                 400 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                405                 410                 415     


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            420                 425                 430         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        435                 440                 445             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    450                 455                 460                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
465                 470                 475                 480 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                485                 490                 495     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            500                 505                 510         


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        515                 520                 525             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly 
    530                 535                 540                 


Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile 
545                 550                 555                 560 


Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met 
                565                 570                 575     


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys 
            580                 585                 590         


Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met 
        595                 600                 605             


Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys 
    610                 615                 620                 


Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val 
625                 630                 635                 640 


Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala 
                645                 650                 655     


Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr 
            660                 665                 670         


Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile 
        675                 680                 685             


Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile 
    690                 695                 700                 


Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile 
705                 710                 715                 720 


Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys 
                725                 730                 735     


Leu Ser Ser 
            


<210>  405
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS51674 tandem CAR with dnTGFbetaRII

<400>  405

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Asn Leu Tyr Ser Tyr Tyr Met His Trp Val Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser 
            100                 105                 110         


Ser Tyr Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Phe Gly Trp Gly 
145                 150                 155                 160 


Tyr Ala Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185                 190         


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
        195                 200                 205             


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
    210                 215                 220                 


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
225                 230                 235                 240 


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
                245                 250                 255     


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
            260                 265                 270         


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ala Pro Ile Thr 
        275                 280                 285             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro 
    290                 295                 300                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
305                 310                 315                 320 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                325                 330                 335     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            340                 345                 350         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        355                 360                 365             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    370                 375                 380                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
385                 390                 395                 400 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                405                 410                 415     


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            420                 425                 430         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        435                 440                 445             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    450                 455                 460                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
465                 470                 475                 480 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                485                 490                 495     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            500                 505                 510         


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe 
        515                 520                 525             


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
    530                 535                 540                 


Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp 
545                 550                 555                 560 


Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn 
                565                 570                 575     


Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln 
            580                 585                 590         


Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys 
        595                 600                 605             


Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln 
    610                 615                 620                 


Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu 
625                 630                 635                 640 


Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu 
                645                 650                 655     


Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro 
            660                 665                 670         


Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp 
        675                 680                 685             


Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu 
    690                 695                 700                 


Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly 
705                 710                 715                 720 


Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg 
                725                 730                 735     


Gln Gln Lys Leu Ser Ser 
            740         


<210>  406
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS65233 tandem CAR with dnTGFbetaRII

<400>  406

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val His Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Glu Phe Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Glu Arg Glu Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr 
            100                 105                 110         


Val Tyr Ala Asp Ser Val Lys Gly Arg Phe Val Leu Ser Arg Tyr Asn 
        115                 120                 125             


Ala Lys Ser Ile Met Tyr Leu Gln Met Asn Ser Val Lys Leu Glu Asp 
    130                 135                 140                 


Thr Ala Met Tyr Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp 
145                 150                 155                 160 


Ser Ser Pro Ser Ser Phe Asp Phe Trp Gly Gln Gly Thr Gln Val Thr 
                165                 170                 175     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            180                 185                 190         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        195                 200                 205             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    210                 215                 220                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
225                 230                 235                 240 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                245                 250                 255     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            260                 265                 270         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        275                 280                 285             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    290                 295                 300                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
305                 310                 315                 320 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                325                 330                 335     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            340                 345                 350         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        355                 360                 365             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    370                 375                 380                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
385                 390                 395                 400 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                405                 410                 415     


Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly 
            420                 425                 430         


Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile 
        435                 440                 445             


Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp 
    450                 455                 460                 


Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val 
465                 470                 475                 480 


Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser 
                485                 490                 495     


Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp 
            500                 505                 510         


Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro 
        515                 520                 525             


Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys 
    530                 535                 540                 


Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys 
545                 550                 555                 560 


Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu 
                565                 570                 575     


Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr 
            580                 585                 590         


Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile 
        595                 600                 605             


Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    610                 615                 620             


<210>  407
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS60685 tandem CAR with dnTGFbetaRII

<400>  407

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Asn Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ser Met Tyr Val Gly Gly 
            100                 105                 110         


Gly Tyr Thr Tyr Tyr Asp Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys 
    130                 135                 140                 


Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ile Ser Ile Ala Leu 
145                 150                 155                 160 


Thr Arg Glu Phe Cys Ala Pro Ile Val Ser Arg Tyr Asn Tyr Trp Gly 
                165                 170                 175     


Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            180                 185                 190         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        195                 200                 205             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    210                 215                 220                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
225                 230                 235                 240 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                245                 250                 255     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            260                 265                 270         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        275                 280                 285             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    290                 295                 300                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
305                 310                 315                 320 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                325                 330                 335     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            340                 345                 350         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        355                 360                 365             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    370                 375                 380                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
385                 390                 395                 400 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                405                 410                 415     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly 
            420                 425                 430         


Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr 
        435                 440                 445             


Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn 
    450                 455                 460                 


Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu 
465                 470                 475                 480 


Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser 
                485                 490                 495     


Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu 
            500                 505                 510         


Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu 
        515                 520                 525             


Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu 
    530                 535                 540                 


Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly 
545                 550                 555                 560 


Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn 
                565                 570                 575     


Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu 
            580                 585                 590         


Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val 
        595                 600                 605             


Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln 
    610                 615                 620                 


Gln Lys Leu Ser Ser 
625                 


<210>  408
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS60702 tandem CAR with dnTGFbetaRII

<400>  408

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Asn Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ser Ile Tyr Val Gly Gly 
            100                 105                 110         


Gly Tyr Thr Asn Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys 
    130                 135                 140                 


Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ile Thr Val Ala Leu 
145                 150                 155                 160 


Thr Arg Ala Phe Cys Ala Pro Ile Pro Ser Arg Tyr Thr Asn Trp Gly 
                165                 170                 175     


Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            180                 185                 190         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        195                 200                 205             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    210                 215                 220                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
225                 230                 235                 240 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                245                 250                 255     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            260                 265                 270         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        275                 280                 285             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    290                 295                 300                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
305                 310                 315                 320 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                325                 330                 335     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            340                 345                 350         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        355                 360                 365             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    370                 375                 380                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
385                 390                 395                 400 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                405                 410                 415     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly 
            420                 425                 430         


Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr 
        435                 440                 445             


Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn 
    450                 455                 460                 


Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu 
465                 470                 475                 480 


Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser 
                485                 490                 495     


Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu 
            500                 505                 510         


Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu 
        515                 520                 525             


Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu 
    530                 535                 540                 


Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly 
545                 550                 555                 560 


Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn 
                565                 570                 575     


Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu 
            580                 585                 590         


Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val 
        595                 600                 605             


Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln 
    610                 615                 620                 


Gln Lys Leu Ser Ser 
625                 


<210>  409
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS60676 tandem CAR with dnTGFbetaRII

<400>  409

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Tyr Thr Val Ser Ser Gly Cys Met Gly Trp Phe Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Glu Arg Glu Arg Val Ala Gln Ile Gly Arg Asp Ala 
            100                 105                 110         


Thr Thr Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ala Arg 
        115                 120                 125             


Asp Asp Ala Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    130                 135                 140                 


Glu Asp Thr Ala Met Tyr Ser Cys Thr Ala Tyr Trp Gly Val Tyr Cys 
145                 150                 155                 160 


Leu Ser Pro Gly Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                165                 170                 175     


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            180                 185                 190         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
        195                 200                 205             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
    210                 215                 220                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                245                 250                 255     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            260                 265                 270         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        275                 280                 285             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
    290                 295                 300                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
305                 310                 315                 320 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                325                 330                 335     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            340                 345                 350         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        355                 360                 365             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    370                 375                 380                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 395                 400 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                405                 410                 415     


Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly Leu Trp 
            420                 425                 430         


Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro 
        435                 440                 445             


His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn 
    450                 455                 460                 


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
465                 470                 475                 480 


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
                485                 490                 495     


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
            500                 505                 510         


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
        515                 520                 525             


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
    530                 535                 540                 


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
545                 550                 555                 560 


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
                565                 570                 575     


Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile 
            580                 585                 590         


Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe 
        595                 600                 605             


Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    610                 615                 620     


<210>  410
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD58126VH3VL1 + FSHbeta 33-53 dual CAR with dnTGFbetaRII

<400>  410

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly His Thr Asp 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Ala Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Asn Trp Ala Trp Phe Pro Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
145                 150                 155                 160 


Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys 
                165                 170                 175     


Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
            180                 185                 190         


Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
225                 230                 235                 240 


Asp Val Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe 
                485                 490                 495     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
        515                 520                 525             


Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg 
    530                 535                 540                 


Pro Lys Ile Gln Lys Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg 
545                 550                 555                 560 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
                565                 570                 575     


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
            580                 585                 590         


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
        595                 600                 605             


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
    610                 615                 620                 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
625                 630                 635                 640 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
                645                 650                 655     


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
            660                 665                 670         


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        675                 680                 685             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    690                 695                 700                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
705                 710                 715                 720 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                725                 730                 735     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            740                 745                 750         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        755                 760                 765             


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
    770                 775                 780                 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg 
785                 790                 795                 800 


Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg 
                805                 810                 815     


Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp 
            820                 825                 830         


Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys 
        835                 840                 845             


Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys 
    850                 855                 860                 


Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val 
865                 870                 875                 880 


Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr 
                885                 890                 895     


Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp 
            900                 905                 910         


Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu 
        915                 920                 925             


Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile 
    930                 935                 940                 


Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val 
945                 950                 955                 960 


Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala 
                965                 970                 975     


Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln 
            980                 985                 990         


Lys Leu Ser Ser 
        995     


<210>  411
<211>  992
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51489 + FSHbeta 33-53 dual CAR with dnTGFbetaRII

<400>  411

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Tyr Tyr Tyr Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Pro Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu 
        195                 200                 205             


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Gly Phe Ser Tyr Tyr Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            500                 505                 510         


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        515                 520                 525             


Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
    530                 535                 540                 


Lys Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
545                 550                 555                 560 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                565                 570                 575     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            580                 585                 590         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        595                 600                 605             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
    610                 615                 620                 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
625                 630                 635                 640 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
                645                 650                 655     


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            660                 665                 670         


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        675                 680                 685             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    690                 695                 700                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
705                 710                 715                 720 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                725                 730                 735     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            740                 745                 750         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        755                 760                 765             


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
    770                 775                 780                 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg 
785                 790                 795                 800 


Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr 
                805                 810                 815     


Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
            820                 825                 830         


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
        835                 840                 845             


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
    850                 855                 860                 


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
865                 870                 875                 880 


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
                885                 890                 895     


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
            900                 905                 910         


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
        915                 920                 925             


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
    930                 935                 940                 


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
945                 950                 955                 960 


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
                965                 970                 975     


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
            980                 985                 990         


<210>  412
<211>  991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS92110 + FSHbeta 33-53 dual CAR with dnTGFbetaRII

<400>  412

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Tyr Tyr Ser Ser Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Tyr Ile Tyr Pro Tyr Tyr Ser Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ala Leu Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Ala Ser Ser Gly Tyr His Tyr Leu Ile Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                325                 330                 335     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            340                 345                 350         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        355                 360                 365             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                485                 490                 495     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr 
            500                 505                 510         


Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr 
        515                 520                 525             


Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys 
    530                 535                 540                 


Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
545                 550                 555                 560 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
                565                 570                 575     


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
            580                 585                 590         


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
        595                 600                 605             


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
    610                 615                 620                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
625                 630                 635                 640 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                645                 650                 655     


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
            660                 665                 670         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        675                 680                 685             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    690                 695                 700                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
705                 710                 715                 720 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                725                 730                 735     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            740                 745                 750         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        755                 760                 765             


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
    770                 775                 780                 


Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly 
785                 790                 795                 800 


Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile 
                805                 810                 815     


Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp 
            820                 825                 830         


Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val 
        835                 840                 845             


Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser 
    850                 855                 860                 


Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp 
865                 870                 875                 880 


Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro 
                885                 890                 895     


Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys 
            900                 905                 910         


Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys 
        915                 920                 925             


Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu 
    930                 935                 940                 


Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr 
945                 950                 955                 960 


Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile 
                965                 970                 975     


Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
            980                 985                 990     


<210>  413
<211>  989
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91156 + FSHbeta 33-53 dual CAR with dnTGFbetaRII

<400>  413

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Tyr Ser Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Ser Ser Tyr Ser Ser Tyr Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Gly Pro Tyr Tyr His Pro Ile Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu 
            500                 505                 510         


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg 
        515                 520                 525             


Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys 
    530                 535                 540                 


Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
545                 550                 555                 560 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                565                 570                 575     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            580                 585                 590         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        595                 600                 605             


Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
    610                 615                 620                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
625                 630                 635                 640 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                645                 650                 655     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            660                 665                 670         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        675                 680                 685             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    690                 695                 700                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
705                 710                 715                 720 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                725                 730                 735     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            740                 745                 750         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760                 765             


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    770                 775                 780                 


Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly Leu Trp 
785                 790                 795                 800 


Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro 
                805                 810                 815     


His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn 
            820                 825                 830         


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
        835                 840                 845             


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
    850                 855                 860                 


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
865                 870                 875                 880 


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
                885                 890                 895     


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
            900                 905                 910         


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
        915                 920                 925             


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
    930                 935                 940                 


Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile 
945                 950                 955                 960 


Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe 
                965                 970                 975     


Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
            980                 985                 


<210>  414
<211>  989
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS91189 + FSHbeta 33-53 dual CAR with dnTGFbetaRII

<400>  414

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Ser Tyr Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Trp Gly Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                165                 170                 175     


Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Tyr Tyr Trp Tyr Tyr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu 
            500                 505                 510         


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg 
        515                 520                 525             


Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys 
    530                 535                 540                 


Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
545                 550                 555                 560 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                565                 570                 575     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            580                 585                 590         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        595                 600                 605             


Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
    610                 615                 620                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
625                 630                 635                 640 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                645                 650                 655     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            660                 665                 670         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        675                 680                 685             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    690                 695                 700                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
705                 710                 715                 720 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                725                 730                 735     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            740                 745                 750         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760                 765             


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    770                 775                 780                 


Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly Leu Trp 
785                 790                 795                 800 


Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro 
                805                 810                 815     


His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn 
            820                 825                 830         


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
        835                 840                 845             


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
    850                 855                 860                 


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
865                 870                 875                 880 


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
                885                 890                 895     


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
            900                 905                 910         


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
        915                 920                 925             


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
    930                 935                 940                 


Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile 
945                 950                 955                 960 


Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe 
                965                 970                 975     


Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
            980                 985                 


<210>  415
<211>  992
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS51674 + FSHbeta 33-53 dual CAR with dnTGFbetaRII

<400>  415

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Leu Tyr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr Ser 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Pro Phe Gly Trp Gly Tyr Ala Gly Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
        195                 200                 205             


Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Gly Tyr Ala Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            500                 505                 510         


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        515                 520                 525             


Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln 
    530                 535                 540                 


Lys Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
545                 550                 555                 560 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                565                 570                 575     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            580                 585                 590         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        595                 600                 605             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg 
    610                 615                 620                 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
625                 630                 635                 640 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
                645                 650                 655     


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            660                 665                 670         


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        675                 680                 685             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    690                 695                 700                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
705                 710                 715                 720 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                725                 730                 735     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            740                 745                 750         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        755                 760                 765             


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
    770                 775                 780                 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg 
785                 790                 795                 800 


Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr 
                805                 810                 815     


Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
            820                 825                 830         


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
        835                 840                 845             


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
    850                 855                 860                 


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
865                 870                 875                 880 


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
                885                 890                 895     


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
            900                 905                 910         


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
        915                 920                 925             


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
    930                 935                 940                 


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
945                 950                 955                 960 


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
                965                 970                 975     


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
            980                 985                 990         


<210>  416
<211>  873
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233 + FSHbeta 33-53 dual CAR with dnTGFbetaRII

<400>  416

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val His Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe 
        35                  40                  45              


Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
    50                  55                  60                  


Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Val Leu Ser Arg Tyr Asn Ala Lys Ser Ile 
                85                  90                  95      


Met Tyr Leu Gln Met Asn Ser Val Lys Leu Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser 
        115                 120                 125             


Ser Phe Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
        355                 360                 365             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    370                 375                 380                 


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
385                 390                 395                 400 


Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr 
                405                 410                 415     


Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Thr Thr 
            420                 425                 430         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        435                 440                 445             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    450                 455                 460                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
465                 470                 475                 480 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490                 495     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            500                 505                 510         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        515                 520                 525             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    530                 535                 540                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
545                 550                 555                 560 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                565                 570                 575     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            580                 585                 590         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        595                 600                 605             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    610                 615                 620                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
625                 630                 635                 640 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
                645                 650                 655     


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
            660                 665                 670         


Gly Pro Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile 
        675                 680                 685             


Val Leu Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys 
    690                 695                 700                 


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
705                 710                 715                 720 


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
                725                 730                 735     


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
            740                 745                 750         


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
        755                 760                 765             


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
    770                 775                 780                 


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
785                 790                 795                 800 


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
                805                 810                 815     


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
            820                 825                 830         


Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro 
        835                 840                 845             


Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg 
    850                 855                 860                 


Val Asn Arg Gln Gln Lys Leu Ser Ser 
865                 870             


<210>  417
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60685 + FSHbeta 33-53 dual CAR with dnTGFbetaRII

<400>  417

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ser Met Tyr Val Gly Gly Gly Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Asp Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ile Ser Ile Ala Leu Thr Arg Glu Phe 
        115                 120                 125             


Cys Ala Pro Ile Val Ser Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                165                 170                 175     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        195                 200                 205             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    370                 375                 380                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr 
385                 390                 395                 400 


Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr 
                405                 410                 415     


Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys 
            420                 425                 430         


Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        435                 440                 445             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    450                 455                 460                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
465                 470                 475                 480 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                485                 490                 495     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
            500                 505                 510         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        515                 520                 525             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    530                 535                 540                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
545                 550                 555                 560 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                565                 570                 575     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            580                 585                 590         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        595                 600                 605             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    610                 615                 620                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
625                 630                 635                 640 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                645                 650                 655     


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
            660                 665                 670         


Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly 
        675                 680                 685             


Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile 
    690                 695                 700                 


Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp 
705                 710                 715                 720 


Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val 
                725                 730                 735     


Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser 
            740                 745                 750         


Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp 
        755                 760                 765             


Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro 
    770                 775                 780                 


Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys 
785                 790                 795                 800 


Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys 
                805                 810                 815     


Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu 
            820                 825                 830         


Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr 
        835                 840                 845             


Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile 
    850                 855                 860                 


Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
865                 870                 875                 


<210>  418
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60702 + FSHbeta 33-53 dual CAR with dnTGFbetaRII

<400>  418

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Val Tyr Asn Asn Met Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ser Ile Tyr Val Gly Gly Gly Tyr Thr Asn 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ile Thr Val Ala Leu Thr Arg Ala Phe 
        115                 120                 125             


Cys Ala Pro Ile Pro Ser Arg Tyr Thr Asn Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                165                 170                 175     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        195                 200                 205             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    370                 375                 380                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr 
385                 390                 395                 400 


Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr 
                405                 410                 415     


Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys 
            420                 425                 430         


Thr Cys Thr Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        435                 440                 445             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    450                 455                 460                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
465                 470                 475                 480 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                485                 490                 495     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
            500                 505                 510         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        515                 520                 525             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    530                 535                 540                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
545                 550                 555                 560 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                565                 570                 575     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            580                 585                 590         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        595                 600                 605             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    610                 615                 620                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
625                 630                 635                 640 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                645                 650                 655     


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
            660                 665                 670         


Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly 
        675                 680                 685             


Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile 
    690                 695                 700                 


Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp 
705                 710                 715                 720 


Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val 
                725                 730                 735     


Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser 
            740                 745                 750         


Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp 
        755                 760                 765             


Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro 
    770                 775                 780                 


Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys 
785                 790                 795                 800 


Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys 
                805                 810                 815     


Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu 
            820                 825                 830         


Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr 
        835                 840                 845             


Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile 
    850                 855                 860                 


Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
865                 870                 875                 


<210>  419
<211>  871
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS60676 + FSHbeta 33-53 dual CAR with dnTGFbetaRII

<400>  419

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Thr Val Ser Ser Gly Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Arg Val Ala Gln Ile Gly Arg Asp Ala Thr Thr Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asp Ala Glu 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Ser Cys Thr Ala Tyr Trp Gly Val Tyr Cys Leu Ser Pro Gly 
        115                 120                 125             


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr 
    130                 135                 140                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
145                 150                 155                 160 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                165                 170                 175     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            180                 185                 190         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        195                 200                 205             


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    210                 215                 220                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
225                 230                 235                 240 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                245                 250                 255     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
            260                 265                 270         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        275                 280                 285             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    290                 295                 300                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
305                 310                 315                 320 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                325                 330                 335     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            340                 345                 350         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
        355                 360                 365             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    370                 375                 380                 


Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
385                 390                 395                 400 


Leu Leu His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp 
                405                 410                 415     


Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Thr Thr Thr Pro 
            420                 425                 430         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        435                 440                 445             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    450                 455                 460                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
465                 470                 475                 480 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                485                 490                 495     


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            500                 505                 510         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        515                 520                 525             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
    530                 535                 540                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
545                 550                 555                 560 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                565                 570                 575     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            580                 585                 590         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        595                 600                 605             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    610                 615                 620                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
625                 630                 635                 640 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn 
                645                 650                 655     


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            660                 665                 670         


Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
        675                 680                 685             


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
    690                 695                 700                 


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
705                 710                 715                 720 


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
                725                 730                 735     


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
            740                 745                 750         


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
        755                 760                 765             


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
    770                 775                 780                 


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
785                 790                 795                 800 


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
                805                 810                 815     


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
            820                 825                 830         


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
        835                 840                 845             


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
    850                 855                 860                 


Arg Gln Gln Lys Leu Ser Ser 
865                 870     


<210>  420
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233VH4

<400>  420

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Tyr Ser Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser His Ile 
        35                  40                  45              


Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg 
                85                  90                  95      


Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  421
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233VH5

<400>  421

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Tyr Ser Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala His Ile 
        35                  40                  45              


Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Arg 
                85                  90                  95      


Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  422
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233VH6

<400>  422

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Tyr Ser Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val Ala His Ile 
        35                  40                  45              


Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Arg 
                85                  90                  95      


Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  423
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444VH4

<400>  423

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp Ser Val 
    50                  55                  60                  


Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn Gly Tyr 
            100                 105                 110         


Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  424
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444VH5

<400>  424

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp Ser Val 
    50                  55                  60                  


Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn Gly Tyr 
            100                 105                 110         


Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  425
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444VH6

<400>  425

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp Ser Val 
    50                  55                  60                  


Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn Gly Tyr 
            100                 105                 110         


Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  426
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533VH4

<400>  426

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser Thr Tyr 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr 
            100                 105                 110         


Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  427
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533VH5

<400>  427

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser Thr Tyr 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr 
            100                 105                 110         


Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  428
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533VH6

<400>  428

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser Thr Tyr 
            20                  25                  30          


Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn Gly Tyr 
            100                 105                 110         


Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  429
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TC-210

<400>  429

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Gly Asp Trp Ser Ala Asn Phe Met Tyr Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gln Arg Glu Leu Val Ala Arg Ile Ser Gly Arg Gly Val Val Asp 
65                  70                  75                  80  


Tyr Val Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Val Ala Ser Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr 
145                 150                 155                 160 


Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro 
                165                 170                 175     


Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile 
            180                 185                 190         


Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu 
        195                 200                 205             


Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys 
    210                 215                 220                 


Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu 
225                 230                 235                 240 


Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val 
                245                 250                 255     


Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu 
            260                 265                 270         


Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val 
        275                 280                 285             


Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu 
    290                 295                 300                 


Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly 
305                 310                 315                 320 


Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
                325                 330             


<210>  430
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3epsilon signal peptide

<400>  430

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln 
            20          


<210>  431
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3gamma signal peptide

<400>  431

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala 
            20          


<210>  432
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3delta signal peptide

<400>  432

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro 
            20      


<210>  433
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3epsilon extracellular domain

<400>  433

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp 
            100                 


<210>  434
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3gamma extracellular domain

<400>  434

Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr Gln Glu 
1               5                   10                  15      


Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr 
            20                  25                  30          


Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp Lys Lys 
        35                  40                  45              


Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln 
    50                  55                  60                  


Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg 
65                  70                  75                  80  


Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser 
                85                  90                  


<210>  435
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3delta extracellular domain

<400>  435

Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys 
1               5                   10                  15      


Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser 
            20                  25                  30          


Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly 
        35                  40                  45              


Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr 
    50                  55                  60                  


Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro 
65                  70                  75                  80  


Ala Thr Val Ala 
                


<210>  436
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3epsilon transmembrane domain

<400>  436

Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  437
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3gamma transmembrane domain

<400>  437

Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly 
1               5                   10                  15      


Val Tyr Phe Ile Ala 
            20      


<210>  438
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3delta transmembrane domain

<400>  438

Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu Ala Leu Gly 
1               5                   10                  15      


Val Phe Cys Phe Ala 
            20      


<210>  439
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3epsilon intracelluar domain

<400>  439

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile 
    50                  55  


<210>  440
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3gamma intracelluar domain

<400>  440

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
        35                  40                  45  


<210>  441
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3delta intracelluar domain

<400>  441

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        35                  40                  45  


<210>  442
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 epsilonTCR

<400>  442

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro 
            20                  25                  30          


Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Gly Asn Glu Glu Met 
    50                  55                  60                  


Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr 
65                  70                  75                  80  


Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln 
                85                  90                  95      


His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly 
            100                 105                 110         


Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln 
        115                 120                 125             


Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala 
    130                 135                 140                 


Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu 
145                 150                 155                 160 


Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile 
                165                 170                 175     


Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys 
            180                 185                 190         


Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln 
        195                 200                 205             


Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr 
    210                 215                 220                 


Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln 
225                 230                 235                 240 


Arg Arg Ile 
            


<210>  443
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53  gammaTCR

<400>  443

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro 
            20                  25                  30          


Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ile Lys Gly Asn 
    50                  55                  60                  


His Leu Val Lys Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu 
65                  70                  75                  80  


Thr Cys Asp Ala Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys 
                85                  90                  95      


Met Ile Gly Phe Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser 
            100                 105                 110         


Asn Ala Lys Asp Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn 
        115                 120                 125             


Lys Ser Lys Pro Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile 
    130                 135                 140                 


Glu Leu Asn Ala Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val 
145                 150                 155                 160 


Ser Ile Phe Val Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp 
                165                 170                 175     


Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn 
            180                 185                 190         


Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser 
        195                 200                 205             


His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
    210                 215             


<210>  444
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53  deltaTCR

<400>  444

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Lys Ile Pro Ile Glu Glu 
    50                  55                  60                  


Leu Glu Asp Arg Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val 
65                  70                  75                  80  


Glu Gly Thr Val Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu 
                85                  90                  95      


Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr 
            100                 105                 110         


Asp Ile Tyr Lys Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met 
        115                 120                 125             


Cys Gln Ser Cys Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile 
    130                 135                 140                 


Val Thr Asp Val Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys 
145                 150                 155                 160 


Phe Ala Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln 
                165                 170                 175     


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            180                 185                 190         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        195                 200                 205         


<210>  445
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233VH5 CAR

<400>  445

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe 
        35                  40                  45              


Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Met Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser 
        115                 120                 125             


Ser Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365     


<210>  446
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444VH5 CAR

<400>  446

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Asn Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu 
        115                 120                 125             


Ala Val Asn Gly Tyr Asn His Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  447
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533VH4 CAR

<400>  447

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu 
        35                  40                  45              


Ser Phe Ser Thr Tyr Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val 
65                  70                  75                  80  


Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu 
        115                 120                 125             


Ala Ile Asn Gly Tyr Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg 
    


<210>  448
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS65233VH5 tandem CAR

<400>  448

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Glu Phe Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly 
                85                  90                  95      


Lys Gly Leu Glu Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr 
            100                 105                 110         


Val Tyr Ala Asp Ser Val Lys Gly Arg Phe Val Leu Ser Arg Asp Asn 
        115                 120                 125             


Ser Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    130                 135                 140                 


Thr Ala Met Tyr Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp 
145                 150                 155                 160 


Ser Ser Pro Ser Ser Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr 
                165                 170                 175     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            180                 185                 190         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        195                 200                 205             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    210                 215                 220                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
225                 230                 235                 240 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                245                 250                 255     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            260                 265                 270         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        275                 280                 285             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    290                 295                 300                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
305                 310                 315                 320 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                325                 330                 335     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            340                 345                 350         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        355                 360                 365             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    370                 375                 380                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
385                 390                 395                 400 


Pro Arg 
        


<210>  449
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS80444VH5 tandem CAR

<400>  449

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Phe Thr Phe Ser Arg Asn Thr Met Gly Trp Phe Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Gly Val Ser Ala Ile Pro Tyr Thr Ser 
            100                 105                 110         


Thr Gly Ile Val Tyr Ser Asp Ser Val Gly Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly 
145                 150                 155                 160 


Thr Thr Met Leu Ala Val Asn Gly Tyr Asn His Trp Gly Gln Gly Thr 
                165                 170                 175     


Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            180                 185                 190         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        195                 200                 205             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    210                 215                 220                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                245                 250                 255     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            260                 265                 270         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        275                 280                 285             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    290                 295                 300                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
305                 310                 315                 320 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                325                 330                 335     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            340                 345                 350         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        355                 360                 365             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    370                 375                 380                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
385                 390                 395                 400 


Ala Leu Pro Pro Arg 
                405 


<210>  450
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS80533VH4 tandem CAR

<400>  450

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala 
            20                  25                  30          


Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    50                  55                  60                  


Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
65                  70                  75                  80  


Ala Ser Gly Leu Ser Phe Ser Thr Tyr Thr Val Ala Trp Phe Arg Gln 
                85                  90                  95      


Ala Pro Gly Lys Gly Leu Glu Gly Val Ala Ala Ile Pro Tyr Thr Ser 
            100                 105                 110         


Gln His Met Val Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    130                 135                 140                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly 
145                 150                 155                 160 


Thr Ser Met Leu Ala Ile Asn Gly Tyr Asn Arg Trp Gly Gln Gly Thr 
                165                 170                 175     


Thr Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            180                 185                 190         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        195                 200                 205             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    210                 215                 220                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                245                 250                 255     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            260                 265                 270         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        275                 280                 285             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    290                 295                 300                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
305                 310                 315                 320 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                325                 330                 335     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            340                 345                 350         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        355                 360                 365             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    370                 375                 380                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
385                 390                 395                 400 


Ala Leu Pro Pro Arg 
                405 


<210>  451
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233VH5 + FSHbeta 33-53 dual CAR

<400>  451

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe 
        35                  40                  45              


Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Met Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser 
        115                 120                 125             


Ser Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
        355                 360                 365             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    370                 375                 380                 


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
385                 390                 395                 400 


Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr 
                405                 410                 415     


Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Thr Thr 
            420                 425                 430         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        435                 440                 445             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    450                 455                 460                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
465                 470                 475                 480 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490                 495     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            500                 505                 510         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        515                 520                 525             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    530                 535                 540                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
545                 550                 555                 560 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                565                 570                 575     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            580                 585                 590         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        595                 600                 605             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    610                 615                 620                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
625                 630                 635                 640 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                645                 650         


<210>  452
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444VH5 + FSHbeta 33-53 dual CAR

<400>  452

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Asn Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu 
        115                 120                 125             


Ala Val Asn Gly Tyr Asn His Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
    370                 375                 380                 


Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu 
385                 390                 395                 400 


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg Asp 
                405                 410                 415     


Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr 
            420                 425                 430         


Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        435                 440                 445             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    450                 455                 460                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
465                 470                 475                 480 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                485                 490                 495     


Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            500                 505                 510         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        515                 520                 525             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    530                 535                 540                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
545                 550                 555                 560 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                565                 570                 575     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            580                 585                 590         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        595                 600                 605             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    610                 615                 620                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
625                 630                 635                 640 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                645                 650                 655 


<210>  453
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533VH4 FSHbeta 33-53 dual CAR

<400>  453

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu 
        35                  40                  45              


Ser Phe Ser Thr Tyr Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val 
65                  70                  75                  80  


Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu 
        115                 120                 125             


Ala Ile Asn Gly Tyr Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
    370                 375                 380                 


Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu 
385                 390                 395                 400 


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg Asp 
                405                 410                 415     


Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr 
            420                 425                 430         


Phe Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        435                 440                 445             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    450                 455                 460                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
465                 470                 475                 480 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                485                 490                 495     


Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            500                 505                 510         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        515                 520                 525             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    530                 535                 540                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
545                 550                 555                 560 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                565                 570                 575     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            580                 585                 590         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        595                 600                 605             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    610                 615                 620                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
625                 630                 635                 640 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                645                 650                 655 


<210>  454
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233VH5 CAR + FSHbeta 33-53 epsilonTCR

<400>  454

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe 
        35                  40                  45              


Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Met Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser 
        115                 120                 125             


Ser Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
        355                 360                 365             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    370                 375                 380                 


Asn Pro Gly Pro Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu 
385                 390                 395                 400 


Cys Leu Leu Ser Val Gly Val Trp Gly Gln Tyr Thr Arg Asp Leu Val 
                405                 410                 415     


Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Gly 
        435                 440                 445             


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
    450                 455                 460                 


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
465                 470                 475                 480 


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
                485                 490                 495     


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
            500                 505                 510         


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
        515                 520                 525             


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
    530                 535                 540                 


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
545                 550                 555                 560 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
                565                 570                 575     


Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
            580                 585                 590         


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
        595                 600                 605             


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
    610                 615                 620                 


Gly Leu Asn Gln Arg Arg Ile 
625                 630     


<210>  455
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444VH5 CAR + FSHbeta 33-53 epsilonTCR

<400>  455

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Asn Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu 
        115                 120                 125             


Ala Val Asn Gly Tyr Asn His Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
    370                 375                 380                 


Val Glu Glu Asn Pro Gly Pro Met Gln Ser Gly Thr His Trp Arg Val 
385                 390                 395                 400 


Leu Gly Leu Cys Leu Leu Ser Val Gly Val Trp Gly Gln Tyr Thr Arg 
                405                 410                 415     


Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys 
            420                 425                 430         


Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
    450                 455                 460                 


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
465                 470                 475                 480 


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
                485                 490                 495     


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
            500                 505                 510         


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
        515                 520                 525             


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
    530                 535                 540                 


Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile 
545                 550                 555                 560 


Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr 
                565                 570                 575     


Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly 
            580                 585                 590         


Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro 
        595                 600                 605             


Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp 
    610                 615                 620                 


Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
625                 630                 


<210>  456
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533VH4 CAR + FSHbeta 33-53 epsilonTCR

<400>  456

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu 
        35                  40                  45              


Ser Phe Ser Thr Tyr Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Gly Val Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val 
65                  70                  75                  80  


Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu 
        115                 120                 125             


Ala Ile Asn Gly Tyr Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    210                 215                 220                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
225                 230                 235                 240 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                245                 250                 255     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            260                 265                 270         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        275                 280                 285             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    290                 295                 300                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
305                 310                 315                 320 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                325                 330                 335     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            340                 345                 350         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        355                 360                 365             


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
    370                 375                 380                 


Val Glu Glu Asn Pro Gly Pro Met Gln Ser Gly Thr His Trp Arg Val 
385                 390                 395                 400 


Leu Gly Leu Cys Leu Leu Ser Val Gly Val Trp Gly Gln Tyr Thr Arg 
                405                 410                 415     


Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys 
            420                 425                 430         


Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
    450                 455                 460                 


Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
465                 470                 475                 480 


Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
                485                 490                 495     


Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
            500                 505                 510         


Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
        515                 520                 525             


Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
    530                 535                 540                 


Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile 
545                 550                 555                 560 


Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr 
                565                 570                 575     


Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly 
            580                 585                 590         


Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro 
        595                 600                 605             


Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp 
    610                 615                 620                 


Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
625                 630                 


<210>  457
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 epsilonTCR with dnTGF RII

<400>  457

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gln Ser 
    210                 215                 220                 


Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser Val Gly Val 
225                 230                 235                 240 


Trp Gly Gln Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro 
                245                 250                 255     


Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Gly Asn Glu Glu Met Gly Gly Ile 
        275                 280                 285             


Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu 
    290                 295                 300                 


Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp 
305                 310                 315                 320 


Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu 
                325                 330                 335     


Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr 
            340                 345                 350         


Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr 
        355                 360                 365             


Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val 
    370                 375                 380                 


Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly 
385                 390                 395                 400 


Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala 
                405                 410                 415     


Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln 
            420                 425                 430         


Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile 
        435                 440                 445             


Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
    450                 455                 460                 


<210>  458
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 gammaTCR with dnTGF RII

<400>  458

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Gln 
    210                 215                 220                 


Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu Leu Gln Gly 
225                 230                 235                 240 


Thr Leu Ala Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro 
                245                 250                 255     


Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gln Ser Ile Lys Gly Asn His Leu Val 
        275                 280                 285             


Lys Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp 
    290                 295                 300                 


Ala Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly 
305                 310                 315                 320 


Phe Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys 
                325                 330                 335     


Asp Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys 
            340                 345                 350         


Pro Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn 
        355                 360                 365             


Ala Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe 
    370                 375                 380                 


Val Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg 
385                 390                 395                 400 


Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu 
                405                 410                 415     


Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln 
            420                 425                 430         


Gly Asn Gln Leu Arg Arg Asn 
        435                 


<210>  459
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 deltaTCR with dnTGF RII

<400>  459

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu His 
    210                 215                 220                 


Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu Ser Gln Val 
225                 230                 235                 240 


Ser Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
                245                 250                 255     


Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp 
        275                 280                 285             


Arg Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr 
    290                 295                 300                 


Val Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg 
305                 310                 315                 320 


Ile Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr 
                325                 330                 335     


Lys Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser 
            340                 345                 350         


Cys Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp 
        355                 360                 365             


Val Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly 
    370                 375                 380                 


His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu 
385                 390                 395                 400 


Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln 
                405                 410                 415     


Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
            420                 425             


<210>  460
<211>  587
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233VH5 CAR with dnTGF RII

<400>  460

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Tyr Ser 
            260                 265                 270         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala 
        275                 280                 285             


His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys 
    290                 295                 300                 


Gly Arg Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr Leu 
305                 310                 315                 320 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                325                 330                 335     


Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp 
            340                 345                 350         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro 
        355                 360                 365             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    370                 375                 380                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
385                 390                 395                 400 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                405                 410                 415     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            420                 425                 430         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        435                 440                 445             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    450                 455                 460                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                485                 490                 495     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            500                 505                 510         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        515                 520                 525             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    530                 535                 540                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
545                 550                 555                 560 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                565                 570                 575     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585         


<210>  461
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444VH5 CAR with dnTGF RII

<400>  461

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            260                 265                 270         


Arg Asn Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        275                 280                 285             


Gly Val Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp 
    290                 295                 300                 


Ser Val Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
305                 310                 315                 320 


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr 
                325                 330                 335     


Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn 
            340                 345                 350         


Gly Tyr Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
        355                 360                 365             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    370                 375                 380                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
385                 390                 395                 400 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                405                 410                 415     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            420                 425                 430         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        435                 440                 445             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    450                 455                 460                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
465                 470                 475                 480 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                485                 490                 495     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            500                 505                 510         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        515                 520                 525             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    530                 535                 540                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
545                 550                 555                 560 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                565                 570                 575     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585                 590 


<210>  462
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533VH4 CAR with dnTGF RII

<400>  462

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser 
            260                 265                 270         


Thr Tyr Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        275                 280                 285             


Gly Val Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp 
    290                 295                 300                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
305                 310                 315                 320 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                325                 330                 335     


Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn 
            340                 345                 350         


Gly Tyr Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr 
        355                 360                 365             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    370                 375                 380                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
385                 390                 395                 400 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                405                 410                 415     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            420                 425                 430         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        435                 440                 445             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    450                 455                 460                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
465                 470                 475                 480 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                485                 490                 495     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            500                 505                 510         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        515                 520                 525             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    530                 535                 540                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
545                 550                 555                 560 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                565                 570                 575     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585                 590 


<210>  463
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS65233VH5 tandem CAR with dnTGF RII

<400>  463

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
                245                 250                 255     


Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu 
    290                 295                 300                 


Phe Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Val Ala His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala 
                325                 330                 335     


Asp Ser Val Lys Gly Arg Phe Val Leu Ser Arg Asp Asn Ser Lys Asn 
            340                 345                 350         


Thr Met Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met 
        355                 360                 365             


Tyr Tyr Cys Ala Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro 
    370                 375                 380                 


Ser Ser Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 400 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
                405                 410                 415     


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            420                 425                 430         


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        435                 440                 445             


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    450                 455                 460                 


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
465                 470                 475                 480 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                485                 490                 495     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            500                 505                 510         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        515                 520                 525             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    530                 535                 540                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
545                 550                 555                 560 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                565                 570                 575     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            580                 585                 590         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        595                 600                 605             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620             


<210>  464
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS80444VH5 tandem CAR with dnTGF RII

<400>  464

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
                245                 250                 255     


Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Arg Asn Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Gly Val Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile 
                325                 330                 335     


Val Tyr Ser Asp Ser Val Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Met Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Thr Met 
    370                 375                 380                 


Leu Ala Val Asn Gly Tyr Asn His Trp Gly Gln Gly Thr Leu Val Thr 
385                 390                 395                 400 


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                405                 410                 415     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            420                 425                 430         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        435                 440                 445             


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    450                 455                 460                 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
465                 470                 475                 480 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                485                 490                 495     


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            500                 505                 510         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        515                 520                 525             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    530                 535                 540                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
545                 550                 555                 560 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                565                 570                 575     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            580                 585                 590         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        595                 600                 605             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    610                 615                 620                 


Pro Arg 
625     


<210>  465
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHbeta 33-53 + AS80533VH4 tandem CAR with dnTGF RII

<400>  465

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
                245                 250                 255     


Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Leu Ser Phe Ser Thr Tyr Thr Val Ala Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Gly Val Ala Ala Ile Pro Tyr Thr Ser Gln His Met 
                325                 330                 335     


Val Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Ser Met 
    370                 375                 380                 


Leu Ala Ile Asn Gly Tyr Asn Arg Trp Gly Gln Gly Thr Thr Val Thr 
385                 390                 395                 400 


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                405                 410                 415     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            420                 425                 430         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        435                 440                 445             


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    450                 455                 460                 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
465                 470                 475                 480 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                485                 490                 495     


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            500                 505                 510         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        515                 520                 525             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    530                 535                 540                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
545                 550                 555                 560 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                565                 570                 575     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            580                 585                 590         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        595                 600                 605             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    610                 615                 620                 


Pro Arg 
625     


<210>  466
<211>  873
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233VH5 + FSHbeta 33-53 dual CAR with dnTGF RII

<400>  466

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Tyr Ser 
            260                 265                 270         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala 
        275                 280                 285             


His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys 
    290                 295                 300                 


Gly Arg Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr Leu 
305                 310                 315                 320 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                325                 330                 335     


Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp 
            340                 345                 350         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro 
        355                 360                 365             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    370                 375                 380                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
385                 390                 395                 400 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                405                 410                 415     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            420                 425                 430         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        435                 440                 445             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    450                 455                 460                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                485                 490                 495     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            500                 505                 510         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        515                 520                 525             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    530                 535                 540                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
545                 550                 555                 560 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                565                 570                 575     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
            580                 585                 590         


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
        595                 600                 605             


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
    610                 615                 620                 


Leu His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro 
625                 630                 635                 640 


Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Thr Thr Thr Pro Ala 
                645                 650                 655     


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
            660                 665                 670         


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
        675                 680                 685             


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
    690                 695                 700                 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
705                 710                 715                 720 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                725                 730                 735     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            740                 745                 750         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        755                 760                 765             


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    770                 775                 780                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
785                 790                 795                 800 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                805                 810                 815     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            820                 825                 830         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        835                 840                 845             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    850                 855                 860                 


Leu His Met Gln Ala Leu Pro Pro Arg 
865                 870             


<210>  467
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444VH5 + FSHbeta 33-53 dual CAR with dnTGF RII

<400>  467

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            260                 265                 270         


Arg Asn Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        275                 280                 285             


Gly Val Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp 
    290                 295                 300                 


Ser Val Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
305                 310                 315                 320 


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr 
                325                 330                 335     


Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn 
            340                 345                 350         


Gly Tyr Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
        355                 360                 365             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    370                 375                 380                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
385                 390                 395                 400 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                405                 410                 415     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            420                 425                 430         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        435                 440                 445             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    450                 455                 460                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
465                 470                 475                 480 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                485                 490                 495     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            500                 505                 510         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        515                 520                 525             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    530                 535                 540                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
545                 550                 555                 560 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                565                 570                 575     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
            580                 585                 590         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        595                 600                 605             


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
    610                 615                 620                 


Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr 
625                 630                 635                 640 


Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Thr Thr 
                645                 650                 655     


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            660                 665                 670         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        675                 680                 685             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    690                 695                 700                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
705                 710                 715                 720 


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
                725                 730                 735     


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            740                 745                 750         


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
        755                 760                 765             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
    770                 775                 780                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
785                 790                 795                 800 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                805                 810                 815     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            820                 825                 830         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        835                 840                 845             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    850                 855                 860                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
865                 870                 875     


<210>  468
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533VH4 + FSHbeta 33-53 dual CAR with dnTGF RII

<400>  468

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser 
            260                 265                 270         


Thr Tyr Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        275                 280                 285             


Gly Val Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp 
    290                 295                 300                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
305                 310                 315                 320 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                325                 330                 335     


Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn 
            340                 345                 350         


Gly Tyr Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr 
        355                 360                 365             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    370                 375                 380                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
385                 390                 395                 400 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                405                 410                 415     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            420                 425                 430         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        435                 440                 445             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    450                 455                 460                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
465                 470                 475                 480 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                485                 490                 495     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            500                 505                 510         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        515                 520                 525             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    530                 535                 540                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
545                 550                 555                 560 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                565                 570                 575     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
            580                 585                 590         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        595                 600                 605             


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
    610                 615                 620                 


Ala Leu Leu Leu His Ala Ala Arg Pro Tyr Thr Arg Asp Leu Val Tyr 
625                 630                 635                 640 


Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Thr Thr 
                645                 650                 655     


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            660                 665                 670         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        675                 680                 685             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    690                 695                 700                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
705                 710                 715                 720 


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
                725                 730                 735     


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            740                 745                 750         


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
        755                 760                 765             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
    770                 775                 780                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
785                 790                 795                 800 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                805                 810                 815     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            820                 825                 830         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        835                 840                 845             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    850                 855                 860                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
865                 870                 875     


<210>  469
<211>  852
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS65233VH5 CAR + FSHbeta 33-53 epsilonTCR with dnTGF RII

<400>  469

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Tyr Ser 
            260                 265                 270         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala 
        275                 280                 285             


His Ile Tyr Thr Arg Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys 
    290                 295                 300                 


Gly Arg Phe Val Leu Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr Leu 
305                 310                 315                 320 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                325                 330                 335     


Ala Arg Thr Ile Phe Glu Gly Ser Trp Ser Ser Pro Ser Ser Phe Asp 
            340                 345                 350         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro 
        355                 360                 365             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    370                 375                 380                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
385                 390                 395                 400 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                405                 410                 415     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            420                 425                 430         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        435                 440                 445             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    450                 455                 460                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                485                 490                 495     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            500                 505                 510         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        515                 520                 525             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    530                 535                 540                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
545                 550                 555                 560 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                565                 570                 575     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
            580                 585                 590         


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
        595                 600                 605             


Pro Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu 
    610                 615                 620                 


Ser Val Gly Val Trp Gly Gln Tyr Thr Arg Asp Leu Val Tyr Lys Asp 
625                 630                 635                 640 


Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly Gly Gly Gly 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Gly Asn Glu Glu 
            660                 665                 670         


Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr 
        675                 680                 685             


Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp 
    690                 695                 700                 


Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile 
705                 710                 715                 720 


Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu 
                725                 730                 735     


Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp 
            740                 745                 750         


Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met 
        755                 760                 765             


Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys 
    770                 775                 780                 


Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg 
785                 790                 795                 800 


Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg 
                805                 810                 815     


Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp 
            820                 825                 830         


Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn 
        835                 840                 845             


Gln Arg Arg Ile 
    850         


<210>  470
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80444VH5 CAR + FSHbeta 33-53 epsilonTCR with dnTGF RII

<400>  470

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            260                 265                 270         


Arg Asn Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        275                 280                 285             


Gly Val Ser Ala Ile Pro Tyr Thr Ser Thr Gly Ile Val Tyr Ser Asp 
    290                 295                 300                 


Ser Val Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
305                 310                 315                 320 


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr 
                325                 330                 335     


Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Thr Met Leu Ala Val Asn 
            340                 345                 350         


Gly Tyr Asn His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
        355                 360                 365             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    370                 375                 380                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
385                 390                 395                 400 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                405                 410                 415     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            420                 425                 430         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        435                 440                 445             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    450                 455                 460                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
465                 470                 475                 480 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                485                 490                 495     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            500                 505                 510         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        515                 520                 525             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    530                 535                 540                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
545                 550                 555                 560 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                565                 570                 575     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
            580                 585                 590         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        595                 600                 605             


Asn Pro Gly Pro Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu 
    610                 615                 620                 


Cys Leu Leu Ser Val Gly Val Trp Gly Gln Tyr Thr Arg Asp Leu Val 
625                 630                 635                 640 


Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Gly 
            660                 665                 670         


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
        675                 680                 685             


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
    690                 695                 700                 


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
705                 710                 715                 720 


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
                725                 730                 735     


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
            740                 745                 750         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        755                 760                 765             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    770                 775                 780                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
785                 790                 795                 800 


Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
                805                 810                 815     


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            820                 825                 830         


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        835                 840                 845             


Gly Leu Asn Gln Arg Arg Ile 
    850                 855 


<210>  471
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS80533VH4 CAR + FSHbeta 33-53 epsilonTCR with dnTGF RII

<400>  471

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser 
            260                 265                 270         


Thr Tyr Thr Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        275                 280                 285             


Gly Val Ala Ala Ile Pro Tyr Thr Ser Gln His Met Val Tyr Thr Asp 
    290                 295                 300                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
305                 310                 315                 320 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                325                 330                 335     


Tyr Cys Ala Thr Asp Arg Arg Pro Gly Thr Ser Met Leu Ala Ile Asn 
            340                 345                 350         


Gly Tyr Asn Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr 
        355                 360                 365             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    370                 375                 380                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
385                 390                 395                 400 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                405                 410                 415     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            420                 425                 430         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        435                 440                 445             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    450                 455                 460                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
465                 470                 475                 480 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                485                 490                 495     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            500                 505                 510         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        515                 520                 525             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    530                 535                 540                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
545                 550                 555                 560 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                565                 570                 575     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
            580                 585                 590         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        595                 600                 605             


Asn Pro Gly Pro Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu 
    610                 615                 620                 


Cys Leu Leu Ser Val Gly Val Trp Gly Gln Tyr Thr Arg Asp Leu Val 
625                 630                 635                 640 


Tyr Lys Asp Pro Ala Arg Pro Lys Ile Gln Lys Thr Cys Thr Phe Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Gly 
            660                 665                 670         


Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser Ile 
        675                 680                 685             


Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser Glu 
    690                 695                 700                 


Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp Asp 
705                 710                 715                 720 


Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe Ser 
                725                 730                 735     


Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Lys 
            740                 745                 750         


Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys Glu 
        755                 760                 765             


Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile Val 
    770                 775                 780                 


Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
785                 790                 795                 800 


Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
                805                 810                 815     


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            820                 825                 830         


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        835                 840                 845             


Gly Leu Asn Gln Arg Arg Ile 
    850                 855 


