                         б

<110>  ̩Ƽ޹˾
             ˹ʽ
 
<120>  ĽTϸ

<130>  P2018TC580

<150>  201810988074.9
<151>  2018-08-28

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  5320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-19еpPVLV1

<400>  1
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      120

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc      180

agtggcgccc gaacagggac ttgaaagcga aagggaaacc agaggagctc tctcgacgca      240

ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc      300

caaaaatttt gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta      360

agcgggggag aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa      420

aatataaatt aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc      480

ctggcctgtt agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc      540

ttcagacagg atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg      600

tgcatcaaag gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc      660

aaaacaaaag taagaccacc gcacagcaag cggccggccg ctgatcttca gacctggagg      720

aggagatatg agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga      780

accattagga gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc      840

agtgggaata ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc      900

agcgtcaatg acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca      960

gaacaatttg ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg     1020

catcaagcag ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct     1080

cctggggatt tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc     1140

tagttggagt aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga     1200

cagagaaatt aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca     1260

gcaagaaaag aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg     1320

gtttaacata acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt     1380

ggtaggttta agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata     1440

ttcaccatta tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg     1500

aatagaagaa gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc     1560

ggcactgcgt gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa     1620

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     1680

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca     1740

gggacagcag agatccagtt tggttagtac cgggcccgac gtcgcatgct cccggccgcc     1800

atggcggccg cgggaattcg attagatccg gtgcccgtca gtgggcagag cgcacatcgc     1860

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt     1920

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg     1980

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg     2040

ccgccagaac acagctgaag cttcgagggg ctcgcatctc tccttcacgc gcccgccgcc     2100

ctacctgagg ccgccatcca cgccggttga gtcgcgttct gccgcctccc gcctgtggtg     2160

cctcctgaac tgcgtccgcc gtctaggtaa gtttaaagct caggtcgaga ccgggccttt     2220

gtccggcgct cccttggagc ctacctagac tcagccggct ctccacgctt tgcctgaccc     2280

tgcttgctca actctacgtc tttgtttcgt tttctgttct gcgccgttac agatccaagc     2340

tgtgaccggc gcctacgtaa gtgatatcta ctagatttat caaaaagagt gttgacttgt     2400

gagcgctcac aattgatact tagattcatc gagagggaca cgtcgactac taaccttctt     2460

ctctttccta cagctgagat cgccggtggg atcccctagg gttaacatgg ccttaccagt     2520

gaccgccttg ctcctgccgc tggccttgct gctccacgcc gccaggccgg acatccagat     2580

gacacagact acatcctccc tgtctgcctc tctgggagac agagtcacca tcagttgcag     2640

ggcaagtcag gacattagta aatatttaaa ttggtatcag cagaaaccag atggaactgt     2700

taaactcctg atctaccata catcaagatt acactcagga gtcccatcaa ggttcagtgg     2760

cagtgggtct ggaacagatt attctctcac cattagcaac ctggagcaag aagatattgc     2820

cacttacttt tgccaacagg gtaatacgct tccgtacacg ttcggagggg ggaccaagct     2880

ggagatcaca ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatctgaggt     2940

gaaactgcag gagtcaggac ctggcctggt ggcgccctca cagagcctgt ccgtcacatg     3000

cactgtctca ggggtctcat tacccgacta tggtgtaagc tggattcgcc agcctccacg     3060

aaagggtctg gagtggctgg gagtaatatg gggtagtgaa accacatact ataattcagc     3120

tctcaaatcc agactgacca tcatcaagga caactccaag agccaagttt tcttaaaaat     3180

gaacagtctg caaactgatg acacagccat ttactactgt gccaaacatt attactacgg     3240

tggtagctat gctatggact actggggcca aggaacctca gtcaccgtct cctcaaccac     3300

gacgccagcg ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct     3360

gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt     3420

cgcctgtgat atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc     3480

actggttatc accctttact gcaaacgggg cagaaagaaa ctcctgtata tattcaaaca     3540

accatttatg agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc     3600

agaagaagaa gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc     3660

cgcgtacaag cagggccaga accagctcta taacgagctc aatctaggac gaagagagga     3720

gtacgatgtt ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag     3780

gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta     3840

cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca     3900

gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc     3960

tcgctaaaca tgtttaaggg ttccggttcc actaggtaca attcgatatc aagcttatcg     4020

ataatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg     4080

ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc     4140

gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt     4200

tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca     4260

ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc     4320

ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc     4380

tgttgggcac tgacaattcc gtggtgttgt cggggaaatc atcgtccttt ccttggctgc     4440

tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc     4500

tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc     4560

ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg catcgatacc     4620

gtcgacctcg atcgagacct agaaaaacat ggagcaatca caagtagcaa tacagcagct     4680

accaatgctg attgtgcctg gctagaagca caagaggagg aggaggtggg ttttccagtc     4740

acacctcagg tacctttaag accaatgact tacaaggcag ctgtagatct tagccacttt     4800

ttaaaagaaa aggggggact ggaagggcta attcactccc aacgaagaca agatatcctt     4860

gatctgtgga tctaccacac acaaggctac ttccctgatt ggcagaacta cacaccaggg     4920

ccagggatca gatatccact gacctttgga tggtgctaca agctagtacc agttgagcaa     4980

gagaaggtag aagaagccaa tgaaggagag aacacccgct tgttacaccc tgtgagcctg     5040

catgggatgg atgacccgga gagagaagta ttagagtgga ggtttgacag ccgcctagca     5100

tttcatcaca tggcccgaga gctgcatccg gactgtactg ggtctctctg gttagaccag     5160

atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc     5220

ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga     5280

tccctcagac ccttttagtc agtgtggaaa atctctagca                           5320


<210>  2
<211>  4417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-19еpPVLV2

<400>  2
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      120

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc      180

agtggcgccc gaacagggac ttgaaagcga aagggaaacc agaggagctc tctcgacgca      240

ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc      300

caaaaatttt gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta      360

agcgggggag aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa      420

aatataaatt aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc      480

ctggcctgtt agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc      540

ttcagacagg atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg      600

tgcatcaaag gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc      660

aaaacaaaag taagaccacc gcacagcaag cggccgctga tcttcagacc tggaggagga      720

gatatgaggg acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca      780

ttaggagtag cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg      840

ggaataggag ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg      900

tcaatgacgc tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac      960

aatttgctga gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc     1020

aagcagctcc aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg     1080

gggatttggg gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt     1140

tggagtaata aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga     1200

gaaattaaca attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa     1260

gaaaagaatg aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt     1320

aacataacaa attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta     1380

ggtttaagaa tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca     1440

ccattatcgt ttcagaccca cctcccaacc ccgaggggac ccgacaggcc cgaaggaata     1500

gaagaagaag gtggagagag agacagagac agatccattc gattagtgaa cggatcggca     1560

ctgcgtgcgc caattctgca gacaaatggc agtattcatc cacaatttta aaagaaaagg     1620

ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa cagacataca     1680

aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt attacaggga     1740

cagcagagat ccagtttggt taaattcgct agctaggtct tgaaaggagt gggaattggc     1800

tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa gttgggggga     1860

ggggtcggca attgatccgg tgcctagaga aggtggcgcg gggtaaactg ggaaagtgat     1920

gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat aagtgcagta     1980

gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacagga ccggttctag     2040

aatggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc acgccgccag     2100

gccggacatc cagatgacac agactacatc ctccctgtct gcctctctgg gagacagagt     2160

caccatcagt tgcagggcaa gtcaggacat tagtaaatat ttaaattggt atcagcagaa     2220

accagatgga actgttaaac tcctgatcta ccatacatca agattacact caggagtccc     2280

atcaaggttc agtggcagtg ggtctggaac agattattct ctcaccatta gcaacctgga     2340

gcaagaagat attgccactt acttttgcca acagggtaat acgcttccgt acacgttcgg     2400

aggggggacc aagctggaga tcacaggtgg cggtggctcg ggcggtggtg ggtcgggtgg     2460

cggcggatct gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc cctcacagag     2520

cctgtccgtc acatgcactg tctcaggggt ctcattaccc gactatggtg taagctggat     2580

tcgccagcct ccacgaaagg gtctggagtg gctgggagta atatggggta gtgaaaccac     2640

atactataat tcagctctca aatccagact gaccatcatc aaggacaact ccaagagcca     2700

agttttctta aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa     2760

acattattac tacggtggta gctatgctat ggactactgg ggccaaggaa cctcagtcac     2820

cgtctcctca accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc     2880

gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac     2940

gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg     3000

ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct     3060

gtatatattc aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg     3120

tagctgccga tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag     3180

gagcgcagac gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct     3240

aggacgaaga gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg     3300

gggaaagccg agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa     3360

gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca     3420

cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat     3480

gcaggccctg ccccctcgct gaggatccac gcgttaagtc gacaatcaac ctctggatta     3540

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     3600

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     3660

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     3720

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     3780

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     3840

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     3900

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     3960

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     4020

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     4080

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     4140

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     4200

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     4260

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     4320

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc     4380

ctcagaccct tttagtcagt gtggaaaatc tctagca                              4417


<210>  3
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'HIV R-U5-gag

<400>  3
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      120

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc      180

agtggcgccc gaacagggac ttgaaagcga aagggaaacc agaggagctc tctcgacgca      240

ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc      300

caaaaatttt gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta      360

agcgggggag aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa      420

aatataaatt aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc      480

ctggcctgtt agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc      540

ttcagacagg atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg      600

tgcatcaaag gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc      660

aaaacaaaag taaga                                                       675


<210>  4
<211>  858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HIV-psi ()

<400>  4
gatcttcaga cctggaggag gagatatgag ggacaattgg agaagtgaat tatataaata       60

taaagtagta aaaattgaac cattaggagt agcacccacc aaggcaaaga gaagagtggt      120

gcagagagaa aaaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc      180

aggaagcact atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc      240

tggtatagtg cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt      300

gcaactcaca gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaaagata      360

cctaaaggat caacagctcc tggggatttg gggttgctct ggaaaactca tttgcaccac      420

tgctgtgcct tggaatgcta gttggagtaa taaatctctg gaacagattt ggaatcacac      480

gacctggatg gagtgggaca gagaaattaa caattacaca agcttaatac actccttaat      540

tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa ttattggaat tagataaatg      600

ggcaagtttg tggaattggt ttaacataac aaattggctg tggtatataa aattattcat      660

aatgatagta ggaggcttgg taggtttaag aatagttttt gctgtacttt ctatagtgaa      720

tagagttagg cagggatatt caccattatc gtttcagacc cacctcccaa ccccgagggg      780

acccgacagg cccgaaggaa tagaagaaga aggtggagag agagacagag acagatccat      840

tcgattagtg aacggatc                                                    858


<210>  5
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RRE

<400>  5
aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat       60

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt      120

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca      180

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcct            234


<210>  6
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cPPT/CTS

<400>  6
ttttaaaaga aaagggggga ttggggggta cagtgcaggg gaaagaatag tagacataat       60

agcaacagac atacaaacta aagaattaca aaaacaaatt acaaaaattc aaaatttt        118


<210>  7
<211>  531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1 ӳ

<400>  7
tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa gttgggggga       60

ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg ggaaagtgat      120

gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat aagtgcagta      180

gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacagct gaagcttcga      240

ggggctcgca tctctccttc acgcgcccgc cgccctacct gaggccgcca tccacgccgg      300

ttgagtcgcg ttctgccgcc tcccgcctgt ggtgcctcct gaactgcgtc cgccgtctag      360

gtaagtttaa agctcaggtc gagaccgggc ctttgtccgg cgctcccttg gagcctacct      420

agactcagcc ggctctccac gctttgcctg accctgcttg ctcaactcta cgtctttgtt      480

tcgttttctg ttctgcgccg ttacagatcc aagctgtgac cggcgcctac g               531


<210>  8
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR-19

<400>  8
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgc                                                   1458


<210>  9
<211>  590
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE

<400>  9
taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc       60

tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg      120

tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt atgaggagtt      180

gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg caacccccac      240

tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt tccccctccc      300

tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct      360

gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc cttggctgct      420

cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct      480

caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc ttccgcgtct      540

tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc                 590


<210>  10
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' SIN LTR

<400>  10
atcgagacct agaaaaacat ggagcaatca caagtagcaa tacagcagct accaatgctg       60

attgtgcctg gctagaagca caagaggagg aggaggtggg ttttccagtc acacctcagg      120

tacctttaag accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa      180

aggggggact ggaagggcta attcactccc aacgaagaca agatatcctt gatctgtgga      240

tctaccacac acaaggctac ttccctgatt ggcagaacta cacaccaggg ccagggatca      300

gatatccact gacctttgga tggtgctaca agctagtacc agttgagcaa gagaaggtag      360

aagaagccaa tgaaggagag aacacccgct tgttacaccc tgtgagcctg catgggatgg      420

atgacccgga gagagaagta ttagagtgga ggtttgacag ccgcctagca tttcatcaca      480

tggcccgaga gctgcatccg gactgtactg ggtctctctg gttagaccag atctgagcct      540

gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag      600

tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac      660

ccttttagtc agtgtggaaa atctctagca                                       690


<210>  11
<211>  181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ض̵5'LTR

<400>  11
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      120

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc      180

a                                                                      181


<210>  12
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HIV-psi ()

<400>  12
ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg caagaggcga ggggcggcga       60

ctggtgagta cgccaaaaat tttgactagc ggaggctaga aggagagaga tgggtgcgag      120

agcgtc                                                                 126


<210>  13
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1 Ӷ

<400>  13
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgat       60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  14
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE

<400>  14
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  15
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' LTR -U3

<400>  15
tggaagggct aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc       60

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      120

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      180

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agca            234


<210>  16
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR-19

<400>  16

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  17
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile 
    210                 215                 


<210>  18
<211>  657
<212>  DNA
<213>  Homo sapiens

<400>  18
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcaacc      600

tgggaaaccg gcaagacgcg gaagctcatg gagttcagcg agcactgtgc catcatc         657


