
                                SEQUENCE LISTING

<110> Fred Hutchinson Cancer Research Center
      Veatch, Joshua
      Riddell, Stanley R.

<120> IMMUNOTHERAPY TARGETING KRAS OR HER2 
      ANTIGENS

<130> 360056.472WO

<140> PCT
<141> 2019-08-21

<150> US 62/721,439
<151> 2018-08-22

<160> 77

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V Immunogenic Peptide

<400> 1
Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys
 1               5                  10                  15
Ser Ala Leu Thr Ile Gln Leu Ile Gln
            20                  25

<210> 2
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 alpha

<400> 2
Cys Ala Val Gly Arg Ser Asn Ser Gly Gly Tyr Gln Lys Val Thr Phe
 1               5                  10                  15

<210> 3
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 beta

<400> 3
Cys Ala Trp Ser Ala Leu Ala Gly Ala Arg Asp Thr Gln Tyr Phe
 1               5                  10                  15

<210> 4
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 alpha native nucleic
      acid

<400> 4
tgtgctgtgg gccgatcgaa ttctgggggt taccagaaag ttaccttt                   48

<210> 5
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 alpha codon optimized
      nucleic acid

<400> 5
tgcgccgtgg gcagatctaa tagcggcggc taccagaaag tgaccttt                   48

<210> 6
<211> 310
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Vbeta amino acid

<400> 6
Met Leu Cys Ser Leu Leu Ala Leu Leu Leu Gly Thr Phe Phe Gly Val
 1               5                  10                  15
Arg Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val
            20                  25                  30
Gly Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro
        35                  40                  45
Asn Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu
    50                  55                  60
Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn
65                  70                  75                  80
Leu Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys
                85                  90                  95
Lys Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Ala
            100                 105                 110
Leu Ala Gly Ala Arg Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly
305                 310

<210> 7
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 beta native nucleic acid

<400> 7
tgtgcctgga gtgcgttggc gggagctaga gatacgcagt atttt                      45

<210> 8
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 beta codon optimized
      nucleic acid

<400> 8
tgtgcttgga gtgctctggc aggcgccaga gatacccagt atttt                      45

<210> 9
<211> 276
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Valpha amino acid

<400> 9
Met Leu Leu Glu Leu Ile Pro Leu Leu Gly Ile His Phe Val Leu Arg
 1               5                  10                  15
Thr Ala Arg Ala Gln Ser Val Thr Gln Pro Asp Ile His Ile Thr Val
            20                  25                  30
Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Asn Tyr Ser Tyr Gly Ala
        35                  40                  45
Thr Pro Tyr Leu Phe Trp Tyr Val Gln Ser Pro Gly Gln Gly Leu Gln
    50                  55                  60
Leu Leu Leu Lys Tyr Phe Ser Gly Asp Thr Leu Val Gln Gly Ile Lys
65                  70                  75                  80
Gly Phe Glu Ala Glu Phe Lys Arg Ser Gln Ser Ser Phe Asn Leu Arg
                85                  90                  95
Lys Pro Ser Val His Trp Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val
            100                 105                 110
Gly Arg Ser Asn Ser Gly Gly Tyr Gln Lys Val Thr Phe Gly Ile Gly
        115                 120                 125
Thr Lys Leu Gln Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val
    130                 135                 140
Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe
145                 150                 155                 160
Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp
                165                 170                 175
Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe
            180                 185                 190
Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys
        195                 200                 205
Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro
    210                 215                 220
Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu
225                 230                 235                 240
Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg
                245                 250                 255
Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg
            260                 265                 270
Leu Trp Ser Ser
        275

<210> 10
<211> 1827
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Entire TCR transgene (Nucleic
      acid codon optimized)

<400> 10
atgctttgtt ctttgctggc tctgctgctg ggcaccttct ttggcgtcag aagccagacc      60
atccaccagt ggcctgctac actggtgcag cctgttggaa gccctctgag cctggaatgt     120
accgtggaag gcaccagcaa tcccaacctg tactggtaca gacaggccgc tggaagagga     180
ctgcagctgc tgttttacag cgtcggcatc ggccagatca gcagcgaggt tccacagaat     240
ctgagcgcca gcagacccca ggacagacag tttatcctga gcagcaagaa gctgctgctg     300
agcgacagcg gcttctacct gtgtgcttgg agtgctctgg caggcgccag agatacccag     360
tattttggcc ctggcaccag actgaccgtg ctggaagatc tgaagaacgt gttcccacct     420
gaggtggccg tgttcgagcc ttctgaggcc gagatcagcc acacacagaa agccacactc     480
gtgtgtctgg ccaccggctt ttaccccgat cacgtggaac tgtcttggtg ggtcaacggc     540
aaagaggtgc acagcggcgt ctgcacagat ccccagcctc tgaaagaaca gcccgctctg     600
aacgacagcc ggtactgcct gtctagcaga ctgagagtgt ccgccacctt ctggcagaac     660
cccagaaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa cgatgagtgg     720
acccaggata gagccaagcc tgtgacacag atcgtgtctg ccgaagcctg gggcagagcc     780
gattgtggct ttaccagcga gagctaccag cagggcgtgc tgtctgccac aatcctgtac     840
gagatcctgc tgggaaaagc cactctgtac gccgtgctgg tgtctgccct ggtgctgatg     900
gccatggtca agcggaagga tagcagaggc ggaagcggcg ccacaaactt cagcctgctt     960
aaacaggccg gcgacgtgga agagaacccc ggacctatgc tgctggaact gatccctctg    1020
ctggggattc acttcgtgct gagaaccgct agagcccaga gcgtgaccca gcctgatatc    1080
cacatcaccg tgtctgaggg cgcctctctg gaactgcggt gcaattacag ctacggcgcc    1140
actccttacc tgttttggta cgtgcagagc ccaggccagg gactgcaact cctgctgaag    1200
tactttagcg gcgacaccct ggtgcagggc atcaagggat tcgaggccga gttcaagaga    1260
agccagtcca gcttcaacct gcggaagcct tccgtgcatt ggagtgatgc cgccgagtac    1320
ttttgcgccg tgggcagatc taatagcggc ggctaccaga aagtgacctt tggcatcggc    1380
accaagctgc aagtgatccc caacattcag aaccccgatc ctgcagtgta ccagctgcgg    1440
gacagcaaga gcagcgacaa gagcgtgtgc ctgttcaccg acttcgacag ccagaccaac    1500
gtgtcccaga gcaaggacag cgacgtgtac atcaccgata agtgcgtgct ggacatgcgg    1560
agcatggact tcaagagcaa cagcgccgtg gcctggtcca acaagagcga cttcgcctgc    1620
gccaacgcct tcaacaacag cattatcccc gaggacacat tcttcccaag ccccgagagc    1680
agctgcgacg tgaagctggt ggaaaagagc ttcgagacag acaccaacct gaacttccag    1740
aacctcagcg tgatcggctt ccggatcctg ctgctgaagg tggccggctt caacctgctg    1800
atgaccctgc ggctgtggtc cagctga                                        1827

<210> 11
<211> 608
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Entire TCR transgene AA
      (beta, P2A, alpha)

<400> 11
Met Leu Cys Ser Leu Leu Ala Leu Leu Leu Gly Thr Phe Phe Gly Val
 1               5                  10                  15
Arg Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val
            20                  25                  30
Gly Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro
        35                  40                  45
Asn Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu
    50                  55                  60
Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn
65                  70                  75                  80
Leu Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys
                85                  90                  95
Lys Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Ala
            100                 105                 110
Leu Ala Gly Ala Arg Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
305                 310                 315                 320
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Glu
                325                 330                 335
Leu Ile Pro Leu Leu Gly Ile His Phe Val Leu Arg Thr Ala Arg Ala
            340                 345                 350
Gln Ser Val Thr Gln Pro Asp Ile His Ile Thr Val Ser Glu Gly Ala
        355                 360                 365
Ser Leu Glu Leu Arg Cys Asn Tyr Ser Tyr Gly Ala Thr Pro Tyr Leu
    370                 375                 380
Phe Trp Tyr Val Gln Ser Pro Gly Gln Gly Leu Gln Leu Leu Leu Lys
385                 390                 395                 400
Tyr Phe Ser Gly Asp Thr Leu Val Gln Gly Ile Lys Gly Phe Glu Ala
                405                 410                 415
Glu Phe Lys Arg Ser Gln Ser Ser Phe Asn Leu Arg Lys Pro Ser Val
            420                 425                 430
His Trp Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val Gly Arg Ser Asn
        435                 440                 445
Ser Gly Gly Tyr Gln Lys Val Thr Phe Gly Ile Gly Thr Lys Leu Gln
    450                 455                 460
Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
465                 470                 475                 480
Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
                485                 490                 495
Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
            500                 505                 510
Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
        515                 520                 525
Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
    530                 535                 540
Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
545                 550                 555                 560
Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
                565                 570                 575
Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
            580                 585                 590
Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600                 605

<210> 12
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 alpha

<400> 12
Cys Ala Val Thr Val Val Asn Ala Gly Asn Asn Arg Lys Leu Ile Trp
 1               5                  10                  15

<210> 13
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 beta

<400> 13
Cys Ala Ser Ser Leu Gly Leu Pro Gly Thr Asp Thr Gln Tyr Phe
 1               5                  10                  15

<210> 14
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 alpha native nucleic
      acid

<400> 14
tgtgccgtga cggtggttaa tgctggcaac aaccgtaagc tgatttgg                   48

<210> 15
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 alpha codon optimized
      nucleic acid

<400> 15
tgcgccgtga ccgtggtcaa cgccggcaac aacagaaagc tgatctgg                   48

<210> 16
<211> 313
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Vbeta amino acid

<400> 16
Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala
 1               5                  10                  15
Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr
            20                  25                  30
Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His
        35                  40                  45
Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu
    50                  55                  60
Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro
65                  70                  75                  80
Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu
                85                  90                  95
Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala
            100                 105                 110
Ser Ser Leu Gly Leu Pro Gly Thr Asp Thr Gln Tyr Phe Gly Pro Gly
        115                 120                 125
Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 17
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 beta native nucleic acid

<400> 17
tgtgccagca gtttagggct accagggaca gatacgcagt atttt                      45

<210> 18
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 beta codon optimized
      nucleic acid

<400> 18
tgtgccagca gcctgggact gcccggcacc gatacacagt atttt                      45

<210> 19
<211> 276
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Valpha amino acid

<400> 19
Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg
 1               5                  10                  15
Asp Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu
            20                  25                  30
Ser Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly
        35                  40                  45
Thr Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln
    50                  55                  60
Leu Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys
65                  70                  75                  80
Gly Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg
                85                  90                  95
Lys Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val
            100                 105                 110
Thr Val Val Asn Ala Gly Asn Asn Arg Lys Leu Ile Trp Gly Leu Gly
        115                 120                 125
Thr Ser Leu Ala Val Asn Pro Asn Ile Gln Asn Pro Asp Pro Ala Val
    130                 135                 140
Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe
145                 150                 155                 160
Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp
                165                 170                 175
Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe
            180                 185                 190
Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys
        195                 200                 205
Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro
    210                 215                 220
Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu
225                 230                 235                 240
Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg
                245                 250                 255
Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg
            260                 265                 270
Leu Trp Ser Ser
        275

<210> 20
<211> 1836
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Entire TCR transgene (Nucleic
      acid codon optimized)

<400> 20
atgggatctt ggacactgtg ttgcgtgtcc ctgtgcatcc tggtggccaa gcacacagat      60
gccggcgtga tccagtctcc tagacacgaa gtgaccgaga tgggccaaga agtgaccctg     120
cgctgcaagc ctatcagcgg ccacgattac ctgttctggt acagacagac catgatgaga     180
ggcctggaac tgctgatcta cttcaacaac aacgtgccca tcgacgacag cggcatgccc     240
gaggatagat tcagcgccaa gatgcccaac gccagcttca gcaccctgaa gatccagcct     300
agcgagccca gagatagcgc cgtgtacttt tgtgccagca gcctgggact gcccggcacc     360
gatacacagt attttggccc tggcaccaga ctgaccgtgc tggaagatct gaagaacgtg     420
ttcccacctg aggtggccgt gttcgagcct tctgaggccg agatcagcca cacacagaaa     480
gccacactcg tgtgtctggc caccggcttc tatcccgatc acgtggaact gtcttggtgg     540
gtcaacggca aagaggtgca cagcggcgtc tgtaccgatc ctcagcctct gaaagagcag     600
cccgctctga acgacagcag atactgcctg agcagcagac tgagagtgtc cgccaccttc     660
tggcagaacc ccagaaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac     720
gatgagtgga cccaggatag agccaagcct gtgacacaga tcgtgtctgc cgaagcctgg     780
ggcagagccg attgtggctt taccagcgag agctaccagc agggcgtgct gtctgccaca     840
atcctgtacg agatcctgct gggcaaagcc actctgtacg ccgtgctggt gtctgccctg     900
gtgctgatgg ccatggtcaa gcggaaggat agcagaggcg gaagcggcgc cacaaacttc     960
tcactgctga aacaggccgg cgacgtggaa gagaaccctg gacctatgct gctcctgctg    1020
atccctgtgc tgggcatgat cttcgccctg agagatgcta gagcccagtc cgtgtctcag    1080
cacaaccacc atgtgatcct gagcgaagcc gcctctctgg aactgggctg caattacagc    1140
tacggcggca ccgtgaatct gttttggtac gtgcagtacc ccggccagca tctccagctg    1200
ctgctgaagt actttagcgg cgaccctctg gtcaagggca tcaagggatt cgaggccgag    1260
ttcatcaaga gcaagttcag cttcaacctg cggaagccca gcgtgcagtg gagcgataca    1320
gccgagtatt tctgcgccgt gaccgtggtc aacgccggca acaacagaaa gctgatctgg    1380
ggcctgggca ccagcctggc tgtgaacccc aatattcaga accccgatcc tgcagtgtac    1440
cagctgcggg acagcaagag cagcgacaag agcgtgtgcc tgttcaccga cttcgacagc    1500
cagaccaacg tgtcccagag caaggacagc gacgtgtaca tcaccgataa gtgcgtgctg    1560
gacatgcgga gcatggactt caagagcaac agcgccgtgg cctggtccaa caagagcgac    1620
ttcgcctgcg ccaacgcctt caacaacagc attatccccg aggacacatt cttcccaagc    1680
cccgagagca gctgcgacgt gaagctggtg gaaaagagct tcgagacaga caccaacctg    1740
aacttccaga acctcagcgt gatcggcttc cggatcctgc tgctgaaggt ggccggcttc    1800
aacctgctga tgaccctgcg gctgtggtcc agctga                              1836

<210> 21
<211> 611
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Entire TCR transgene AA
      (beta, P2A, alpha)

<400> 21
Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala
 1               5                  10                  15
Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr
            20                  25                  30
Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His
        35                  40                  45
Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu
    50                  55                  60
Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro
65                  70                  75                  80
Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu
                85                  90                  95
Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala
            100                 105                 110
Ser Ser Leu Gly Leu Pro Gly Thr Asp Thr Gln Tyr Phe Gly Pro Gly
        115                 120                 125
Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe
305                 310                 315                 320
Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met
                325                 330                 335
Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg Asp
            340                 345                 350
Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu Ser
        355                 360                 365
Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly Thr
    370                 375                 380
Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln Leu
385                 390                 395                 400
Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys Gly
                405                 410                 415
Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg Lys
            420                 425                 430
Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val Thr
        435                 440                 445
Val Val Asn Ala Gly Asn Asn Arg Lys Leu Ile Trp Gly Leu Gly Thr
    450                 455                 460
Ser Leu Ala Val Asn Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr
465                 470                 475                 480
Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr
                485                 490                 495
Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val
            500                 505                 510
Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys
        515                 520                 525
Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala
    530                 535                 540
Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser
545                 550                 555                 560
Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr
                565                 570                 575
Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile
            580                 585                 590
Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu
        595                 600                 605
Trp Ser Ser
    610

<210> 22
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HER2 ITD Immunogenic Peptide

<400> 22
Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala
 1               5                  10                  15
Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly
            20                  25                  30

<210> 23
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 alpha

<400> 23
Cys Ala Val Ser Val Asn Thr Asp Lys Leu Ile Phe
 1               5                  10

<210> 24
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 beta

<400> 24
Cys Ser Ala Pro Pro Leu Ala Gly Asp Glu Thr Gln Tyr Phe
 1               5                  10

<210> 25
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 alpha native nucleic
      acid

<400> 25
tgtgctgtga gtgtgaacac cgacaagctc atcttt                                36

<210> 26
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 alpha codon optimized
      nucleic acid

<400> 26
tgcgccgtgt ctgtgaacac cgacaagctg atcttc                                36

<210> 27
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Valpha amino acid

<400> 27
Met Leu Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly
 1               5                  10                  15
Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val
            20                  25                  30
Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val
        35                  40                  45
Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln
    50                  55                  60
Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn
65                  70                  75                  80
Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg
                85                  90                  95
Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val
            100                 105                 110
Ser Val Asn Thr Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln
        115                 120                 125
Val Phe Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
    130                 135                 140
Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
145                 150                 155                 160
Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
                165                 170                 175
Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
            180                 185                 190
Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
        195                 200                 205
Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
    210                 215                 220
Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
225                 230                 235                 240
Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
                245                 250                 255
Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265                 270

<210> 28
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 beta native nucleic acid

<400> 28
tgcagtgctc ctcccctagc gggagatgag acccagtact tc                         42

<210> 29
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR3 beta nucleic acid -
      codon optimized

<400> 29
tgtagcgccc ctccactggc cggcgacgag acacaatatt tt                         42

<210> 30
<211> 308
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Vbeta Amino Acid

<400> 30
Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala
 1               5                  10                  15
Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser
            20                  25                  30
Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe
        35                  40                  45
Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser
    50                  55                  60
Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys
65                  70                  75                  80
Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr
                85                  90                  95
Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Pro Pro
            100                 105                 110
Leu Ala Gly Asp Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu
        115                 120                 125
Val Leu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu
    130                 135                 140
Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys
145                 150                 155                 160
Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val
                165                 170                 175
Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu
            180                 185                 190
Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg
        195                 200                 205
Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg
    210                 215                 220
Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln
225                 230                 235                 240
Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly
                245                 250                 255
Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu
            260                 265                 270
Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr
        275                 280                 285
Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys
    290                 295                 300
Asp Ser Arg Gly
305

<210> 31
<211> 1809
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Entire Nucleic Acid TCR
      Transgene

<400> 31
atgttgcttt tgttgctgct cctcggacct ggctctggac tgggagctgt ggtttctcag      60
cacccctctt gggtcatctg caagagcggc accagcgtga agatcgagtg cagaagcctg     120
gacttccagg ccaccacaat gttctggtac agacagttcc ccaagcagag cctgatgctg     180
atggccacct ctaacgaggg cagcaaggcc acatatgagc agggcgtcga gaaggacaag     240
ttcctgatca accacgccag cctgacactg agcaccctga cagtgacaag cgcccatcct     300
gaggacagca gcttctacat ctgtagcgcc cctccactgg ccggcgacga gacacaatat     360
tttggccctg gcaccagact gctggtgctg gacctgaaga acgtgttccc acctgaggtg     420
gccgtgttcg agccttctga ggccgagatc agccacacac agaaagccac actcgtgtgt     480
ctggccaccg gcttctatcc cgatcacgtc gaactgtctt ggtgggtcaa cggcaaagag     540
gtgcacagcg gcgtctgtac cgatcctcag cctctgaaag agcagcccgc tctgaacgac     600
agcagatact gcctgagcag cagactgaga gtgtccgcca ccttctggca gaaccccaga     660
aaccacttca gatgccaggt gcagttctac ggcctgagcg agaacgatga gtggacccag     720
gatagagcca agcctgtgac acagatcgtg tctgccgaag cctggggcag agccgattgt     780
ggctttacca gcgagagcta ccagcaaggc gtgctgtctg ccaccatcct gtacgagatc     840
ctgctgggca aagccactct gtacgccgtg ctggtgtctg ccctggtcct gatggctatg     900
gtcaagcgga aggatagcag aggcggaagc ggcgccacaa acttctcact gctgaaacag     960
gcaggcgacg tggaagagaa ccccggacct atgctgctgc ttctggtgcc tgccttccaa    1020
gtgatcttta ccctcggcgg cacaagagcc cagagcgtga cacagctgga tagccaggtg    1080
ccagtgttcg aagaggcccc tgtggaactg cggtgcaact acagcagcag cgtgtccgtg    1140
tacctgtttt ggtacgtgca gtaccccaac cagggcctgc agctgctcct gaagtatctg    1200
agcggcagca ccctggtgga atccatcaat ggcttcgagg ccgaattcaa caagagccag    1260
accagcttcc acctgagaaa gcccagcgtg cacatcagcg ataccgccga gtacttctgc    1320
gccgtgtctg tgaacaccga caagctgatc ttcggcaccg gcacaaggct ccaggtgttc    1380
cccaacattc agaaccccga tcctgcagtg taccagctgc gggacagcaa gagcagcgac    1440
aagagcgtgt gcctgttcac cgacttcgac agccagacca acgtgtccca gagcaaggac    1500
agcgacgtgt acatcaccga taagtgcgtg ctggacatgc ggagcatgga cttcaagagc    1560
aacagcgccg tggcctggtc caacaagagc gacttcgcct gcgccaacgc cttcaacaac    1620
agcattatcc ccgaggacac attcttccca agccccgaga gcagctgcga cgtgaagctg    1680
gtggaaaaga gcttcgagac agacaccaac ctgaacttcc agaacctcag cgtgatcggc    1740
ttccggatcc tgctgctgaa ggtggccggc ttcaacctgc tgatgaccct gcggctgtgg    1800
tccagctga                                                            1809

<210> 32
<211> 602
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Entire TCR Amino Acid
      Sequence

<400> 32
Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala
 1               5                  10                  15
Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser
            20                  25                  30
Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe
        35                  40                  45
Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser
    50                  55                  60
Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys
65                  70                  75                  80
Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr
                85                  90                  95
Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Pro Pro
            100                 105                 110
Leu Ala Gly Asp Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu
        115                 120                 125
Val Leu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu
    130                 135                 140
Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys
145                 150                 155                 160
Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val
                165                 170                 175
Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu
            180                 185                 190
Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg
        195                 200                 205
Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg
    210                 215                 220
Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln
225                 230                 235                 240
Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly
                245                 250                 255
Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu
            260                 265                 270
Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr
        275                 280                 285
Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys
    290                 295                 300
Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln
305                 310                 315                 320
Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Leu Val
                325                 330                 335
Pro Ala Phe Gln Val Ile Phe Thr Leu Gly Gly Thr Arg Ala Gln Ser
            340                 345                 350
Val Thr Gln Leu Asp Ser Gln Val Pro Val Phe Glu Glu Ala Pro Val
        355                 360                 365
Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val Ser Val Tyr Leu Phe Trp
    370                 375                 380
Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln Leu Leu Leu Lys Tyr Leu
385                 390                 395                 400
Ser Gly Ser Thr Leu Val Glu Ser Ile Asn Gly Phe Glu Ala Glu Phe
                405                 410                 415
Asn Lys Ser Gln Thr Ser Phe His Leu Arg Lys Pro Ser Val His Ile
            420                 425                 430
Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val Ser Val Asn Thr Asp Lys
        435                 440                 445
Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn Ile Gln
    450                 455                 460
Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp
465                 470                 475                 480
Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser
                485                 490                 495
Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp
            500                 505                 510
Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn
        515                 520                 525
Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro
    530                 535                 540
Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu
545                 550                 555                 560
Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu
                565                 570                 575
Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn
            580                 585                 590
Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
        595                 600

<210> 33
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS WT peptide

<400> 33
Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys
 1               5                  10                  15
Ser Ala Leu Thr Ile Gln Leu Ile Gln
            20                  25

<210> 34
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HER2 WT Peptide

<400> 34
Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala
 1               5                  10                  15
Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly
            20                  25

<210> 35
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence -Thoseaasigna virus 2A (T2A)
      peptide

<400> 35
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
 1               5                  10                  15
Glu Asn Pro Gly Pro
            20

<210> 36
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Porcine teschovirus-1 2A
      (P2A) peptide

<400> 36
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15
Glu Glu Asn Pro Gly Pro
            20

<210> 37
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Equine rhinitis A virus
      (ERAV) 2A (E2A)

<400> 37
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp
 1               5                  10                  15
Val Glu Ser Asn Pro Gly Pro
            20

<210> 38
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Foot-and-mouth disease virus
      2A (F2A) peptide

<400> 38
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala
 1               5                  10                  15
Gly Asp Val Glu Ser Asn Pro Gly Pro
            20                  25

<210> 39
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - mutant peptide

<400> 39
Thr Glu Arg Trp Asp Asn Leu Ile Tyr Tyr
 1               5                  10

<210> 40
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - mutant peptide

<400> 40
Ala Glu Arg Trp Asp Asn Leu Ile Tyr Tyr
 1               5                  10

<210> 41
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Human TCR Cbeta1 Reverse

<400> 41
ccacttccag ggctgccttc agaaatc                                          27

<210> 42
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Human TCR Cbeta2 Reverse

<400> 42
tgggatggtt ttggagctag cctctgg                                          27

<210> 43
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Human TCR Calpha Reverse

<400> 43
cagccgcagc gtcatgagca gatta                                            25

<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - JV298 primer

<400> 44
tcgcttctgt tcgcgcgctt                                                  20

<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - JV300 primer

<400> 45
aacaggcaca cgctcttgtc                                                  20

<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - guide rna

<400> 46
agagtctctc agctggtaca                                                  20

<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - TCR beta guide rna

<400> 47
ggagaatgac gagtggaccc                                                  20

<210> 48
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 3 CDR1alpha

<400> 48
Tyr Gly Ala Thr Pro Tyr
 1               5

<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 3 CDR2alpha

<400> 49
Tyr Phe Ser Gly Asp Thr Leu
 1               5

<210> 50
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 3 TCRalpha
      signal peptide

<400> 50
Met Leu Cys Ser Leu Leu Ala Leu Leu Leu Gly Thr Phe Phe Gly Val
 1               5                  10                  15
Arg Ser Gln Thr
            20

<210> 51
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 3 CDR1beta

<400> 51
Gly Thr Ser Asn Pro Asn
 1               5

<210> 52
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 3 CDR2beta

<400> 52
Ser Val Gly Ile Gly
 1               5

<210> 53
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 3 TCRbeta
      signal peptide

<400> 53
Met Leu Leu Glu Leu Ile Pro Leu Leu Gly Ile His Phe Val Leu Arg
 1               5                  10                  15
Thr Ala


<210> 54
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 9 CDR2alpha

<400> 54
Tyr Gly Gly Thr Val Asn
 1               5

<210> 55
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 9 CDR2alpha

<400> 55
Tyr Phe Ser Gly Asp Pro Leu
 1               5

<210> 56
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 9 TCRalpha
      signal peptide

<400> 56
Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala
 1               5                  10                  15
Lys His Thr Asp
            20

<210> 57
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 9 CDR1beta

<400> 57
Ser Gly His Asp Tyr
 1               5

<210> 58
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 9 CDR2beta

<400> 58
Phe Asn Asn Asn Val Pro
 1               5

<210> 59
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 9 TCRbeta
      signal peptide

<400> 59
Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg
 1               5                  10                  15
Asp Ala Arg Ala Gln
            20

<210> 60
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Her2 ITD TCR CDR1alpha

<400> 60
Ser Ser Val Ser Val Tyr
 1               5

<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Her2 ITD TCR CDR2alpha

<400> 61
Tyr Leu Ser Gly Ser Thr Leu
 1               5

<210> 62
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Her2 ITD TCRalpha signal
      peptide

<400> 62
Met Leu Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly
 1               5                  10                  15
Gly Thr Arg Ala
            20

<210> 63
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Her2 ITD TCR CDR1beta

<400> 63
Asp Phe Gln Ala Thr Thr
 1               5

<210> 64
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Her2 ITD TCR CDR2beta

<400> 64
Ser Asn Glu Gly Ser Lys Ala
 1               5

<210> 65
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Her2 ITD TCRbeta signal
      peptide

<400> 65
Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly
 1               5                  10                  15

<210> 66
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 3 TCR Valpha
      (mature)

<400> 66
Arg Ala Gln Ser Val Thr Gln Pro Asp Ile His Ile Thr Val Ser Glu
 1               5                  10                  15
Gly Ala Ser Leu Glu Leu Arg Cys Asn Tyr Ser Tyr Gly Ala Thr Pro
            20                  25                  30
Tyr Leu Phe Trp Tyr Val Gln Ser Pro Gly Gln Gly Leu Gln Leu Leu
        35                  40                  45
Leu Lys Tyr Phe Ser Gly Asp Thr Leu Val Gln Gly Ile Lys Gly Phe
    50                  55                  60
Glu Ala Glu Phe Lys Arg Ser Gln Ser Ser Phe Asn Leu Arg Lys Pro
65                  70                  75                  80
Ser Val His Trp Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val Gly Arg
                85                  90                  95
Ser Asn Ser Gly Gly Tyr Gln Lys Val Thr Phe Gly Ile Gly Thr Lys
            100                 105                 110
Leu Gln Val Ile Pro Asn
        115

<210> 67
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 3 TCR Calpha

<400> 67
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 68
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 3 TCR Vbeta
      (mature)

<400> 68
Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly Ser Pro Leu
 1               5                  10                  15
Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro Asn Leu Tyr Trp
            20                  25                  30
Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe Tyr Ser Val
        35                  40                  45
Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu Ser Ala Ser
    50                  55                  60
Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys Leu Leu Leu
65                  70                  75                  80
Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Ala Leu Ala Gly Ala
                85                  90                  95
Arg Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu
            100                 105                 110

<210> 69
<211> 178
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 3 TCR Cbeta

<400> 69
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
 1               5                  10                  15
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
            20                  25                  30
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
        35                  40                  45
Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu
    50                  55                  60
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
65                  70                  75                  80
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
                85                  90                  95
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
            100                 105                 110
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
        115                 120                 125
Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala
    130                 135                 140
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
145                 150                 155                 160
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser
                165                 170                 175
Arg Gly


<210> 70
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 9 TCR Valpha
      (mature)

<400> 70
Ser Val Ser Gln His Asn His His Val Ile Leu Ser Glu Ala Ala Ser
 1               5                  10                  15
Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly Thr Val Asn Leu Phe
            20                  25                  30
Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln Leu Leu Leu Lys Tyr
        35                  40                  45
Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys Gly Phe Glu Ala Glu
    50                  55                  60
Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg Lys Pro Ser Val Gln
65                  70                  75                  80
Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val Thr Val Val Asn Ala
                85                  90                  95
Gly Asn Asn Arg Lys Leu Ile Trp Gly Leu Gly Thr Ser Leu Ala Val
            100                 105                 110
Asn Pro Asn
        115

<210> 71
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 9 TCR Calpha

<400> 71
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 72
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 9 TCR Vbeta
      (mature)

<400> 72
Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln
 1               5                  10                  15
Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asp Tyr Leu Phe
            20                  25                  30
Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe
        35                  40                  45
Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe
    50                  55                  60
Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro
65                  70                  75                  80
Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Leu Gly
                85                  90                  95
Leu Pro Gly Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr
            100                 105                 110
Val Leu Glu
        115

<210> 73
<211> 178
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - KRAS G12V clone 9 TCR Cbeta

<400> 73
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
 1               5                  10                  15
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
            20                  25                  30
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
        35                  40                  45
Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu
    50                  55                  60
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
65                  70                  75                  80
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
                85                  90                  95
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
            100                 105                 110
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
        115                 120                 125
Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala
    130                 135                 140
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
145                 150                 155                 160
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser
                165                 170                 175
Arg Gly


<210> 74
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence -  HER2 ITD TCR Valpha (mature)

<400> 74
Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val Phe Glu Glu Ala
 1               5                  10                  15
Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val Ser Val Tyr Leu
            20                  25                  30
Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln Leu Leu Leu Lys
        35                  40                  45
Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn Gly Phe Glu Ala
    50                  55                  60
Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg Lys Pro Ser Val
65                  70                  75                  80
His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val Ser Val Asn Thr
                85                  90                  95
Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe Pro Asn
            100                 105                 110

<210> 75
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence -  HER2 ITD TCR Calpha

<400> 75
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 76
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence -  HER2 ITD TCR Vbeta (mature)

<400> 76
Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr
 1               5                  10                  15
Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met
            20                  25                  30
Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr
        35                  40                  45
Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp
    50                  55                  60
Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val
65                  70                  75                  80
Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Pro
                85                  90                  95
Pro Leu Ala Gly Asp Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu
            100                 105                 110
Leu Val Leu
        115

<210> 77
<211> 178
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - HER2 ITD TCR Cbeta

<400> 77
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
 1               5                  10                  15
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
            20                  25                  30
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
        35                  40                  45
Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu
    50                  55                  60
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
65                  70                  75                  80
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
                85                  90                  95
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
            100                 105                 110
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
        115                 120                 125
Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala
    130                 135                 140
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
145                 150                 155                 160
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser
                165                 170                 175
Arg Gly
