                               SEQUENCE LISTING

<110> SANGAMO THERAPEUTICS, INC.
 
<120> ENGINEERED TARGET SPECIFIC BASE EDITORS

<130> 8325-0180/S180-PCT

<140>
<141>

<150> 62/867,565
<151> 2019-06-27

<150> 62/817,153
<151> 2019-03-12

<150> 62/753,696
<151> 2018-10-31

<150> 62/721,903
<151> 2018-08-23

<160> 92    

<170> PatentIn version 3.5

<210> 1
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(49)
<223> a, c, t, g, unknown or other

<400> 1
nnnnnnnnnn nnnnntctct nnnnnnnnnn nnnnnnnnnn nnnnnnnnn                   49


<210> 2
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210> 3
<211> 58
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Gly Thr Gly Gly Pro Lys Lys Lys Arg Lys Val Tyr Pro Tyr Asp Val 
1               5                   10                  15      


Pro Asp Tyr Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser 
            20                  25                  30          


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser Ala Ala Pro Ala Ala 
        35                  40                  45              


Lys Lys Lys Lys Leu Asp Phe Glu Ser Glu 
    50                  55              


<210> 4
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
gtgctgacca tcgacgagaa agggactgaa gct                                    33


<210> 5
<211> 579
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: FokI
      polypeptide

<400> 5
Met Val Ser Lys Ile Arg Thr Phe Gly Trp Val Gln Asn Pro Gly Lys 
1               5                   10                  15      


Phe Glu Asn Leu Lys Arg Val Val Gln Val Phe Asp Arg Asn Ser Lys 
            20                  25                  30          


Val His Asn Glu Val Lys Asn Ile Lys Ile Pro Thr Leu Val Lys Glu 
        35                  40                  45              


Ser Lys Ile Gln Lys Glu Leu Val Ala Ile Met Asn Gln His Asp Leu 
    50                  55                  60                  


Ile Tyr Thr Tyr Lys Glu Leu Val Gly Thr Gly Thr Ser Ile Arg Ser 
65                  70                  75                  80  


Glu Ala Pro Cys Asp Ala Ile Ile Gln Ala Thr Ile Ala Asp Gln Gly 
                85                  90                  95      


Asn Lys Lys Gly Tyr Ile Asp Asn Trp Ser Ser Asp Gly Phe Leu Arg 
            100                 105                 110         


Trp Ala His Ala Leu Gly Phe Ile Glu Tyr Ile Asn Lys Ser Asp Ser 
        115                 120                 125             


Phe Val Ile Thr Asp Val Gly Leu Ala Tyr Ser Lys Ser Ala Asp Gly 
    130                 135                 140                 


Ser Ala Ile Glu Lys Glu Ile Leu Ile Glu Ala Ile Ser Ser Tyr Pro 
145                 150                 155                 160 


Pro Ala Ile Arg Ile Leu Thr Leu Leu Glu Asp Gly Gln His Leu Thr 
                165                 170                 175     


Lys Phe Asp Leu Gly Lys Asn Leu Gly Phe Ser Gly Glu Ser Gly Phe 
            180                 185                 190         


Thr Ser Leu Pro Glu Gly Ile Leu Leu Asp Thr Leu Ala Asn Ala Met 
        195                 200                 205             


Pro Lys Asp Lys Gly Glu Ile Arg Asn Asn Trp Glu Gly Ser Ser Asp 
    210                 215                 220                 


Lys Tyr Ala Arg Met Ile Gly Gly Trp Leu Asp Lys Leu Gly Leu Val 
225                 230                 235                 240 


Lys Gln Gly Lys Lys Glu Phe Ile Ile Pro Thr Leu Gly Lys Pro Asp 
                245                 250                 255     


Asn Lys Glu Phe Ile Ser His Ala Phe Lys Ile Thr Gly Glu Gly Leu 
            260                 265                 270         


Lys Val Leu Arg Arg Ala Lys Gly Ser Thr Lys Phe Thr Arg Val Pro 
        275                 280                 285             


Lys Arg Val Tyr Trp Glu Met Leu Ala Thr Asn Leu Thr Asp Lys Glu 
    290                 295                 300                 


Tyr Val Arg Thr Arg Arg Ala Leu Ile Leu Glu Ile Leu Ile Lys Ala 
305                 310                 315                 320 


Gly Ser Leu Lys Ile Glu Gln Ile Gln Asp Asn Leu Lys Lys Leu Gly 
                325                 330                 335     


Phe Asp Glu Val Ile Glu Thr Ile Glu Asn Asp Ile Lys Gly Leu Ile 
            340                 345                 350         


Asn Thr Gly Ile Phe Ile Glu Ile Lys Gly Arg Phe Tyr Gln Leu Lys 
        355                 360                 365             


Asp His Ile Leu Gln Phe Val Ile Pro Asn Arg Gly Val Thr Lys Gln 
    370                 375                 380                 


Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys 
385                 390                 395                 400 


Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg 
                405                 410                 415     


Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe 
            420                 425                 430         


Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys 
        435                 440                 445             


Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val 
    450                 455                 460                 


Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly 
465                 470                 475                 480 


Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn 
                485                 490                 495     


Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val 
            500                 505                 510         


Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr 
        515                 520                 525             


Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala 
    530                 535                 540                 


Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala 
545                 550                 555                 560 


Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu 
                565                 570                 575     


Ile Asn Phe 
            


<210> 6
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
atgtttttag aggccatacc catgtcta                                          28


<210> 7
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
gccatgtttt tagaggccat acccatgt                                          28


<210> 8
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
gggccatgtt tttagaggcc atacccat                                          28


<210> 9
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
ggggccatgt ttttagaggc cataccca                                          28


<210> 10
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
ctggggccat gtttttagag gccatacc                                          28


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Thr Gln Ala Thr Leu Gly Val 
1               5           


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Asp Arg Ser His Leu Ala Arg 
1               5           


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gln Ser Ala His Arg Lys Asn 
1               5           


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Ser Thr Ala Ala Leu Ser Tyr 
1               5           


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Thr Ser Gly Ser Leu Thr Arg 
1               5           


<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Ser Asn Gln Asn Leu Thr Thr 
1               5           


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Thr Ser Gly Ser Leu Ser Arg 
1               5           


<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
His Ser Ala Thr Leu Lys Tyr 
1               5           


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gln Asn Ala His Arg Lys Thr 
1               5           


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Thr Ser Ser Asn Arg Ala Val 
1               5           


<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Arg Ser Asp Ala Leu Ser Thr 
1               5           


<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Asp Arg Ser Thr Arg Thr Lys 
1               5           


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Asp Ser Ser His Arg Thr Arg 
1               5           


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Asp Arg Ser Asp Leu Ser Arg 
1               5           


<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Arg Ser Thr His Leu Val Arg 
1               5           


<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Glu Arg Gly Thr Leu Ala Arg 
1               5           


<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Arg Ser Asp His Leu Ser Arg 
1               5           


<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Ser Gly Thr Pro His Glu Val Gly Val Tyr Thr Leu 
1               5                   10          


<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Ser Gly Gly Gly Leu Gly Ser Thr 
1               5               


<210> 30
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
tgtgtctgt                                                                9


<210> 31
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
tgtttctgt                                                                9


<210> 32
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
tgttcctgt                                                                9


<210> 33
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
tgtccctgt                                                                9


<210> 34
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
tttaaattat ggagtatgtt tctgtgga                                          28


<210> 35
<211> 320
<212> PRT
<213> Bos sp.

<400> 35
Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210> 36
<211> 587
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      BPT4 sequence

<400> 36
Met Asp Ile Lys Val His Phe His Asp Phe Ser His Val Arg Ile Asp 
1               5                   10                  15      


Cys Glu Glu Ser Thr Phe His Glu Leu Arg Asp Phe Phe Ser Phe Glu 
            20                  25                  30          


Ala Asp Gly Tyr Arg Phe Asn Pro Arg Phe Arg Tyr Gly Asn Trp Asp 
        35                  40                  45              


Gly Arg Ile Arg Leu Leu Asp Tyr Asn Arg Leu Leu Pro Phe Gly Leu 
    50                  55                  60                  


Val Gly Gln Ile Lys Lys Phe Cys Asp Asn Phe Gly Tyr Lys Ala Trp 
65                  70                  75                  80  


Ile Asp Pro Gln Ile Asn Glu Lys Glu Glu Leu Ser Arg Lys Asp Phe 
                85                  90                  95      


Asp Glu Trp Leu Ser Lys Leu Glu Ile Tyr Ser Gly Asn Lys Arg Ile 
            100                 105                 110         


Glu Pro His Trp Tyr Gln Lys Asp Ala Val Phe Glu Gly Leu Val Asn 
        115                 120                 125             


Arg Arg Arg Ile Leu Asn Leu Pro Thr Ser Ala Gly Lys Ser Leu Ile 
    130                 135                 140                 


Gln Ala Leu Leu Ala Arg Tyr Tyr Leu Glu Asn Tyr Glu Gly Lys Ile 
145                 150                 155                 160 


Leu Ile Ile Val Pro Thr Thr Ala Leu Thr Thr Gln Met Ala Asp Asp 
                165                 170                 175     


Phe Val Asp Tyr Arg Leu Phe Ser His Ala Met Ile Lys Lys Ile Gly 
            180                 185                 190         


Gly Gly Ala Ser Lys Asp Asp Lys Tyr Lys Asn Asp Ala Pro Val Val 
        195                 200                 205             


Val Gly Thr Trp Gln Thr Val Val Lys Gln Pro Lys Glu Trp Phe Ser 
    210                 215                 220                 


Gln Phe Gly Met Met Met Asn Asp Glu Cys His Leu Ala Thr Gly Lys 
225                 230                 235                 240 


Ser Ile Ser Ser Ile Ile Ser Gly Leu Asn Asn Cys Met Phe Lys Phe 
                245                 250                 255     


Gly Leu Ser Gly Ser Leu Arg Asp Gly Lys Ala Asn Ile Met Gln Tyr 
            260                 265                 270         


Val Gly Met Phe Gly Glu Ile Phe Lys Pro Val Thr Thr Ser Lys Leu 
        275                 280                 285             


Met Glu Asp Gly Gln Val Thr Glu Leu Lys Ile Asn Ser Ile Phe Leu 
    290                 295                 300                 


Arg Tyr Pro Asp Glu Phe Thr Thr Lys Leu Lys Gly Lys Thr Tyr Gln 
305                 310                 315                 320 


Glu Glu Ile Lys Ile Ile Thr Gly Leu Ser Lys Arg Asn Lys Trp Ile 
                325                 330                 335     


Ala Lys Leu Ala Ile Lys Leu Ala Gln Lys Asp Glu Asn Ala Phe Val 
            340                 345                 350         


Met Phe Lys His Val Ser His Gly Lys Ala Ile Phe Asp Leu Ile Lys 
        355                 360                 365             


Asn Glu Tyr Asp Lys Val Tyr Tyr Val Ser Gly Glu Val Asp Thr Glu 
    370                 375                 380                 


Thr Arg Asn Ile Met Lys Thr Leu Ala Glu Asn Gly Lys Gly Ile Ile 
385                 390                 395                 400 


Ile Val Ala Ser Tyr Gly Val Phe Ser Thr Gly Ile Ser Val Lys Asn 
                405                 410                 415     


Leu His His Val Val Leu Ala His Gly Val Lys Ser Lys Ile Ile Val 
            420                 425                 430         


Leu Gln Thr Ile Gly Arg Val Leu Arg Lys His Gly Ser Lys Thr Ile 
        435                 440                 445             


Ala Thr Val Trp Asp Leu Ile Asp Ser Ala Gly Val Lys Pro Lys Ser 
    450                 455                 460                 


Ala Asn Thr Lys Lys Lys Tyr Val His Leu Asn Tyr Leu Leu Lys His 
465                 470                 475                 480 


Gly Ile Asp Arg Ile Gln Arg Tyr Ala Asp Glu Lys Phe Asn Tyr Val 
                485                 490                 495     


Met Lys Thr Val Asn Leu Ile Ser Phe Gly Pro Leu Glu Lys Lys Met 
            500                 505                 510         


Leu Leu Glu Phe Lys Gln Phe Leu Tyr Glu Ala Ser Ile Asp Glu Phe 
        515                 520                 525             


Met Gly Lys Ile Ala Ser Cys Gln Thr Leu Glu Gly Leu Glu Glu Leu 
    530                 535                 540                 


Glu Ala Tyr Tyr Lys Lys Arg Val Lys Glu Thr Glu Leu Lys Asp Thr 
545                 550                 555                 560 


Asp Asp Ile Ser Val Arg Asp Ala Leu Ala Gly Lys Arg Ala Glu Leu 
                565                 570                 575     


Glu Asp Ser Asp Asp Glu Val Glu Glu Ser Phe 
            580                 585         


<210> 37
<211> 715
<212> PRT
<213> Deinococcus radiodurans

<400> 37
Met Ser Ala Ala Leu Pro Ala Glu Pro Phe Arg Val Ser Gly Gly Val 
1               5                   10                  15      


Asn Lys Val Arg Phe Arg Ser Asp Thr Gly Phe Thr Val Met Ser Ala 
            20                  25                  30          


Thr Leu Arg Asn Glu Gln Gly Glu Asp Pro Asp Ala Thr Val Ile Gly 
        35                  40                  45              


Val Met Pro Pro Leu Asp Val Gly Asp Thr Phe Ser Ala Glu Val Leu 
    50                  55                  60                  


Met Glu Glu His Arg Glu Tyr Gly Tyr Gln Tyr Arg Val Val Asn Met 
65                  70                  75                  80  


Val Leu Glu Ala Met Pro Ala Asp Leu Ser Glu Glu Gly Val Ala Ala 
                85                  90                  95      


Tyr Phe Glu Ala Arg Val Gly Gly Val Gly Lys Val Leu Ala Gly Arg 
            100                 105                 110         


Ile Ala Lys Thr Phe Gly Ala Ala Ala Phe Asp Leu Leu Glu Asp Asp 
        115                 120                 125             


Pro Gln Lys Phe Leu Gln Val Pro Gly Ile Thr Glu Ser Thr Leu His 
    130                 135                 140                 


Lys Met Val Ser Ser Trp Ser Gln Gln Gly Leu Glu Arg Arg Leu Leu 
145                 150                 155                 160 


Ala Gly Leu Gln Gly Leu Gly Leu Thr Ile Asn Gln Ala Gln Arg Ala 
                165                 170                 175     


Val Lys His Phe Gly Ala Asp Ala Leu Asp Arg Leu Glu Lys Asp Leu 
            180                 185                 190         


Phe Thr Leu Thr Glu Val Glu Gly Ile Gly Phe Leu Thr Ala Asp Lys 
        195                 200                 205             


Leu Trp Gln Ala Arg Gly Gly Ala Leu Asp Asp Pro Arg Arg Leu Thr 
    210                 215                 220                 


Ala Ala Ala Val Tyr Ala Leu Gln Leu Ala Gly Thr Gln Ala Gly His 
225                 230                 235                 240 


Ser Phe Leu Pro Arg Ser Arg Ala Glu Lys Gly Val Val His Tyr Thr 
                245                 250                 255     


Arg Val Thr Pro Gly Gln Ala Arg Leu Ala Val Glu Thr Ala Val Glu 
            260                 265                 270         


Leu Gly Arg Leu Ser Glu Asp Asp Ser Pro Leu Phe Ala Ala Glu Ala 
        275                 280                 285             


Ala Ala Thr Gly Glu Gly Arg Ile Tyr Leu Pro His Val Leu Arg Ala 
    290                 295                 300                 


Glu Lys Lys Leu Ala Ser Leu Ile Arg Thr Leu Leu Ala Thr Pro Pro 
305                 310                 315                 320 


Ala Asp Gly Ala Gly Asn Asp Asp Trp Ala Val Pro Lys Lys Ala Arg 
                325                 330                 335     


Lys Gly Leu Ser Glu Glu Gln Ala Ser Val Leu Asp Gln Leu Ala Gly 
            340                 345                 350         


His Arg Leu Val Val Leu Thr Gly Gly Pro Gly Thr Gly Lys Ser Thr 
        355                 360                 365             


Thr Thr Lys Ala Val Ala Asp Leu Ala Glu Ser Leu Gly Leu Glu Val 
    370                 375                 380                 


Gly Leu Cys Ala Pro Thr Gly Lys Ala Ala Arg Arg Leu Gly Glu Val 
385                 390                 395                 400 


Thr Gly Arg Thr Ala Ser Thr Val His Arg Leu Leu Gly Tyr Gly Pro 
                405                 410                 415     


Gln Gly Phe Arg His Asn His Leu Glu Pro Ala Pro Tyr Asp Leu Leu 
            420                 425                 430         


Ile Val Asp Glu Val Ser Met Met Gly Asp Ala Leu Met Leu Ser Leu 
        435                 440                 445             


Leu Ala Ala Val Pro Pro Gly Ala Arg Val Leu Leu Val Gly Asp Thr 
    450                 455                 460                 


Asp Gln Leu Pro Pro Val Asp Ala Gly Leu Pro Leu Leu Ala Leu Ala 
465                 470                 475                 480 


Gln Ala Ala Pro Thr Ile Lys Leu Thr Gln Val Tyr Arg Gln Ala Ala 
                485                 490                 495     


Lys Asn Pro Ile Ile Gln Ala Ala His Gly Leu Leu His Gly Glu Ala 
            500                 505                 510         


Pro Ala Trp Gly Asp Lys Arg Leu Asn Leu Thr Glu Ile Glu Pro Asp 
        515                 520                 525             


Gly Gly Ala Arg Arg Val Ala Leu Met Val Arg Glu Leu Gly Gly Pro 
    530                 535                 540                 


Gly Ala Val Gln Val Leu Thr Pro Met Arg Lys Gly Pro Leu Gly Met 
545                 550                 555                 560 


Asp His Leu Asn Tyr His Leu Gln Ala Leu Phe Asn Pro Gly Glu Gly 
                565                 570                 575     


Gly Val Arg Ile Ala Glu Gly Glu Ala Arg Pro Gly Asp Thr Val Val 
            580                 585                 590         


Gln Thr Lys Asn Asp Tyr Asn Asn Glu Ile Phe Asn Gly Thr Leu Gly 
        595                 600                 605             


Met Val Leu Lys Ala Glu Gly Ala Arg Leu Thr Val Asp Phe Asp Gly 
    610                 615                 620                 


Asn Val Val Glu Leu Thr Gly Ala Glu Leu Phe Asn Leu Gln Leu Gly 
625                 630                 635                 640 


Tyr Ala Leu Thr Val His Arg Ala Gln Gly Ser Glu Trp Gly Thr Val 
                645                 650                 655     


Leu Gly Val Leu His Glu Ala His Met Pro Met Leu Ser Arg Asn Leu 
            660                 665                 670         


Val Tyr Thr Ala Leu Thr Arg Ala Arg Asp Arg Phe Phe Ser Ala Gly 
        675                 680                 685             


Ser Ala Ser Ala Trp Gln Ile Ala Ala Ala Arg Gln Arg Glu Ala Arg 
    690                 695                 700                 


Asn Thr Ala Leu Leu Glu Arg Ile Arg Ala His 
705                 710                 715 


<210> 38
<211> 353
<212> PRT
<213> Escherichia coli

<400> 38
Met Ala Ile Asp Glu Asn Lys Gln Lys Ala Leu Ala Ala Ala Leu Gly 
1               5                   10                  15      


Gln Ile Glu Lys Gln Phe Gly Lys Gly Ser Ile Met Arg Leu Gly Glu 
            20                  25                  30          


Asp Arg Ser Met Asp Val Glu Thr Ile Ser Thr Gly Ser Leu Ser Leu 
        35                  40                  45              


Asp Ile Ala Leu Gly Ala Gly Gly Leu Pro Met Gly Arg Ile Val Glu 
    50                  55                  60                  


Ile Tyr Gly Pro Glu Ser Ser Gly Lys Thr Thr Leu Thr Leu Gln Val 
65                  70                  75                  80  


Ile Ala Ala Ala Gln Arg Glu Gly Lys Thr Cys Ala Phe Ile Asp Ala 
                85                  90                  95      


Glu His Ala Leu Asp Pro Ile Tyr Ala Arg Lys Leu Gly Val Asp Ile 
            100                 105                 110         


Asp Asn Leu Leu Cys Ser Gln Pro Asp Thr Gly Glu Gln Ala Leu Glu 
        115                 120                 125             


Ile Cys Asp Ala Leu Ala Arg Ser Gly Ala Val Asp Val Ile Val Val 
    130                 135                 140                 


Asp Ser Val Ala Ala Leu Thr Pro Lys Ala Glu Ile Glu Gly Glu Ile 
145                 150                 155                 160 


Gly Asp Ser His Met Gly Leu Ala Ala Arg Met Met Ser Gln Ala Met 
                165                 170                 175     


Arg Lys Leu Ala Gly Asn Leu Lys Gln Ser Asn Thr Leu Leu Ile Phe 
            180                 185                 190         


Ile Asn Gln Ile Arg Met Lys Ile Gly Val Met Phe Gly Asn Pro Glu 
        195                 200                 205             


Thr Thr Thr Gly Gly Asn Ala Leu Lys Phe Tyr Ala Ser Val Arg Leu 
    210                 215                 220                 


Asp Ile Arg Arg Ile Gly Ala Val Lys Glu Gly Glu Asn Val Val Gly 
225                 230                 235                 240 


Ser Glu Thr Arg Val Lys Val Val Lys Asn Lys Ile Ala Ala Pro Phe 
                245                 250                 255     


Lys Gln Ala Glu Phe Gln Ile Leu Tyr Gly Glu Gly Ile Asn Phe Tyr 
            260                 265                 270         


Gly Glu Leu Val Asp Leu Gly Val Lys Glu Lys Leu Ile Glu Lys Ala 
        275                 280                 285             


Gly Ala Trp Tyr Ser Tyr Lys Gly Glu Lys Ile Gly Gln Gly Lys Ala 
    290                 295                 300                 


Asn Ala Thr Ala Trp Leu Lys Asp Asn Pro Glu Thr Ala Lys Glu Ile 
305                 310                 315                 320 


Glu Lys Lys Val Arg Glu Leu Leu Leu Ser Asn Pro Asn Ser Thr Pro 
                325                 330                 335     


Asp Phe Ser Val Asp Asp Ser Glu Gly Val Ala Glu Thr Asn Glu Asp 
            340                 345                 350         


Phe 
    


<210> 39
<211> 1180
<212> PRT
<213> Escherichia coli

<400> 39
Met Ser Asp Val Ala Glu Thr Leu Asp Pro Leu Arg Leu Pro Leu Gln 
1               5                   10                  15      


Gly Glu Arg Leu Ile Glu Ala Ser Ala Gly Thr Gly Lys Thr Phe Thr 
            20                  25                  30          


Ile Ala Ala Leu Tyr Leu Arg Leu Leu Leu Gly Leu Gly Gly Ser Ala 
        35                  40                  45              


Ala Phe Pro Arg Pro Leu Thr Val Glu Glu Leu Leu Val Val Thr Phe 
    50                  55                  60                  


Thr Glu Ala Ala Thr Ala Glu Leu Arg Gly Arg Ile Arg Ser Asn Ile 
65                  70                  75                  80  


His Glu Leu Arg Ile Ala Cys Leu Arg Glu Thr Thr Asp Asn Pro Leu 
                85                  90                  95      


Tyr Glu Arg Leu Leu Glu Glu Ile Asp Asp Lys Ala Gln Ala Ala Gln 
            100                 105                 110         


Trp Leu Leu Leu Ala Glu Arg Gln Met Asp Glu Ala Ala Val Phe Thr 
        115                 120                 125             


Ile His Gly Phe Cys Gln Arg Met Leu Asn Leu Asn Ala Phe Glu Ser 
    130                 135                 140                 


Gly Met Leu Phe Glu Gln Gln Leu Ile Glu Asp Glu Ser Leu Leu Arg 
145                 150                 155                 160 


Tyr Gln Ala Cys Ala Asp Phe Trp Arg Arg His Cys Tyr Pro Leu Pro 
                165                 170                 175     


Arg Glu Ile Ala Gln Val Val Phe Glu Thr Trp Lys Gly Pro Gln Ala 
            180                 185                 190         


Leu Leu Arg Asp Ile Asn Arg Tyr Leu Gln Gly Glu Ala Pro Val Ile 
        195                 200                 205             


Lys Ala Pro Pro Pro Asp Asp Glu Thr Leu Ala Ser Arg His Ala Gln 
    210                 215                 220                 


Ile Val Ala Arg Ile Asp Thr Val Lys Gln Gln Trp Arg Asp Ala Val 
225                 230                 235                 240 


Gly Glu Leu Asp Ala Leu Ile Glu Ser Ser Gly Ile Asp Arg Arg Lys 
                245                 250                 255     


Phe Asn Arg Ser Asn Gln Ala Lys Trp Ile Asp Lys Ile Ser Ala Trp 
            260                 265                 270         


Ala Glu Glu Glu Thr Asn Ser Tyr Gln Leu Pro Glu Ser Leu Glu Lys 
        275                 280                 285             


Phe Ser Gln Arg Phe Leu Glu Asp Arg Thr Lys Ala Gly Gly Glu Thr 
    290                 295                 300                 


Pro Arg His Pro Leu Phe Glu Ala Ile Asp Gln Leu Leu Ala Glu Pro 
305                 310                 315                 320 


Leu Ser Ile Arg Asp Leu Val Ile Thr Arg Ala Leu Ala Glu Ile Arg 
                325                 330                 335     


Glu Thr Val Ala Arg Glu Lys Arg Arg Arg Gly Glu Leu Gly Phe Asp 
            340                 345                 350         


Asp Met Leu Ser Arg Leu Asp Ser Ala Leu Arg Ser Glu Ser Gly Glu 
        355                 360                 365             


Val Leu Ala Ala Ala Ile Arg Thr Arg Phe Pro Val Ala Met Ile Asp 
    370                 375                 380                 


Glu Phe Gln Asp Thr Asp Pro Gln Gln Tyr Arg Ile Phe Arg Arg Ile 
385                 390                 395                 400 


Trp His His Gln Pro Glu Thr Ala Leu Leu Leu Ile Gly Asp Pro Lys 
                405                 410                 415     


Gln Ala Ile Tyr Ala Phe Arg Gly Ala Asp Ile Phe Thr Tyr Met Lys 
            420                 425                 430         


Ala Arg Ser Glu Val His Ala His Tyr Thr Leu Asp Thr Asn Trp Arg 
        435                 440                 445             


Ser Ala Pro Gly Met Val Asn Ser Val Asn Lys Leu Phe Ser Gln Thr 
    450                 455                 460                 


Asp Asp Ala Phe Met Phe Arg Glu Ile Pro Phe Ile Pro Val Lys Ser 
465                 470                 475                 480 


Ala Gly Lys Asn Gln Ala Leu Arg Phe Val Phe Lys Gly Glu Thr Gln 
                485                 490                 495     


Pro Ala Met Lys Met Trp Leu Met Glu Gly Glu Ser Cys Gly Val Gly 
            500                 505                 510         


Asp Tyr Gln Ser Thr Met Ala Gln Val Cys Ala Ala Gln Ile Arg Asp 
        515                 520                 525             


Trp Leu Gln Ala Gly Gln Arg Gly Glu Ala Leu Leu Met Asn Gly Asp 
    530                 535                 540                 


Asp Ala Arg Pro Val Arg Ala Ser Asp Ile Ser Val Leu Val Arg Ser 
545                 550                 555                 560 


Arg Gln Glu Ala Ala Gln Val Arg Asp Ala Leu Thr Leu Leu Glu Ile 
                565                 570                 575     


Pro Ser Val Tyr Leu Ser Asn Arg Asp Ser Val Phe Glu Thr Leu Glu 
            580                 585                 590         


Ala Gln Glu Met Leu Trp Leu Leu Gln Ala Val Met Thr Pro Glu Arg 
        595                 600                 605             


Glu Asn Thr Leu Arg Ser Ala Leu Ala Thr Ser Met Met Gly Leu Asn 
    610                 615                 620                 


Ala Leu Asp Ile Glu Thr Leu Asn Asn Asp Glu His Ala Trp Asp Val 
625                 630                 635                 640 


Val Val Glu Glu Phe Asp Gly Tyr Arg Gln Ile Trp Arg Lys Arg Gly 
                645                 650                 655     


Val Met Pro Met Leu Arg Ala Leu Met Ser Ala Arg Asn Ile Ala Glu 
            660                 665                 670         


Asn Leu Leu Ala Thr Ala Gly Gly Glu Arg Arg Leu Thr Asp Ile Leu 
        675                 680                 685             


His Ile Ser Glu Leu Leu Gln Glu Ala Gly Thr Gln Leu Glu Ser Glu 
    690                 695                 700                 


His Ala Leu Val Arg Trp Leu Ser Gln His Ile Leu Glu Pro Asp Ser 
705                 710                 715                 720 


Asn Ala Ser Ser Gln Gln Met Arg Leu Glu Ser Asp Lys His Leu Val 
                725                 730                 735     


Gln Ile Val Thr Ile His Lys Ser Lys Gly Leu Glu Tyr Pro Leu Val 
            740                 745                 750         


Trp Leu Pro Phe Ile Thr Asn Phe Arg Val Gln Glu Gln Ala Phe Tyr 
        755                 760                 765             


His Asp Arg His Ser Phe Glu Ala Val Leu Asp Leu Asn Ala Ala Pro 
    770                 775                 780                 


Glu Ser Val Asp Leu Ala Glu Ala Glu Arg Leu Ala Glu Asp Leu Arg 
785                 790                 795                 800 


Leu Leu Tyr Val Ala Leu Thr Arg Ser Val Trp His Cys Ser Leu Gly 
                805                 810                 815     


Val Ala Pro Leu Val Arg Arg Arg Gly Asp Lys Lys Gly Asp Thr Asp 
            820                 825                 830         


Val His Gln Ser Ala Leu Gly Arg Leu Leu Gln Lys Gly Glu Pro Gln 
        835                 840                 845             


Asp Ala Ala Gly Leu Arg Thr Cys Ile Glu Ala Leu Cys Asp Asp Asp 
    850                 855                 860                 


Ile Ala Trp Gln Thr Ala Gln Thr Gly Asp Asn Gln Pro Trp Gln Val 
865                 870                 875                 880 


Asn Asp Val Ser Thr Ala Glu Leu Asn Ala Lys Thr Leu Gln Arg Leu 
                885                 890                 895     


Pro Gly Asp Asn Trp Arg Val Thr Ser Tyr Ser Gly Leu Gln Gln Arg 
            900                 905                 910         


Gly His Gly Ile Ala Gln Asp Leu Met Pro Arg Leu Asp Val Asp Ala 
        915                 920                 925             


Ala Gly Val Ala Ser Val Val Glu Glu Pro Thr Leu Thr Pro His Gln 
    930                 935                 940                 


Phe Pro Arg Gly Ala Ser Pro Gly Thr Phe Leu His Ser Leu Phe Glu 
945                 950                 955                 960 


Asp Leu Asp Phe Thr Gln Pro Val Asp Pro Asn Trp Val Arg Glu Lys 
                965                 970                 975     


Leu Glu Leu Gly Gly Phe Glu Ser Gln Trp Glu Pro Val Leu Thr Glu 
            980                 985                 990         


Trp Ile Thr Ala Val Leu Gln Ala  Pro Leu Asn Glu Thr  Gly Val Ser 
        995                 1000                 1005             


Leu Ser  Gln Leu Ser Ala Arg  Asn Lys Gln Val Glu  Met Glu Phe 
    1010                 1015                 1020             


Tyr Leu  Pro Ile Ser Glu Pro  Leu Ile Ala Ser Gln  Leu Asp Thr 
    1025                 1030                 1035             


Leu Ile  Arg Gln Phe Asp Pro  Leu Ser Ala Gly Cys  Pro Pro Leu 
    1040                 1045                 1050             


Glu Phe  Met Gln Val Arg Gly  Met Leu Lys Gly Phe  Ile Asp Leu 
    1055                 1060                 1065             


Val Phe  Arg His Glu Gly Arg  Tyr Tyr Leu Leu Asp  Tyr Lys Ser 
    1070                 1075                 1080             


Asn Trp  Leu Gly Glu Asp Ser  Ser Ala Tyr Thr Gln  Gln Ala Met 
    1085                 1090                 1095             


Ala Ala  Ala Met Gln Ala His  Arg Tyr Asp Leu Gln  Tyr Gln Leu 
    1100                 1105                 1110             


Tyr Thr  Leu Ala Leu His Arg  Tyr Leu Arg His Arg  Ile Ala Asp 
    1115                 1120                 1125             


Tyr Asp  Tyr Glu His His Phe  Gly Gly Val Ile Tyr  Leu Phe Leu 
    1130                 1135                 1140             


Arg Gly  Val Asp Lys Glu His  Pro Gln Gln Gly Ile  Tyr Thr Thr 
    1145                 1150                 1155             


Arg Pro  Asn Ala Gly Leu Ile  Ala Leu Met Asp Glu  Met Phe Ala 
    1160                 1165                 1170             


Gly Met  Thr Leu Glu Glu Ala  
    1175                 1180 


<210> 40
<211> 1122
<212> PRT
<213> Escherichia coli

<400> 40
Met Leu Arg Val Tyr His Ser Asn Arg Leu Asp Val Leu Glu Ala Leu 
1               5                   10                  15      


Met Glu Phe Ile Val Glu Arg Glu Arg Leu Asp Asp Pro Phe Glu Pro 
            20                  25                  30          


Glu Met Ile Leu Val Gln Ser Thr Gly Met Ala Gln Trp Leu Gln Met 
        35                  40                  45              


Thr Leu Ser Gln Lys Phe Gly Ile Ala Ala Asn Ile Asp Phe Pro Leu 
    50                  55                  60                  


Pro Ala Ser Phe Ile Trp Asp Met Phe Val Arg Val Leu Pro Glu Ile 
65                  70                  75                  80  


Pro Lys Glu Ser Ala Phe Asn Lys Gln Ser Met Ser Trp Lys Leu Met 
                85                  90                  95      


Thr Leu Leu Pro Gln Leu Leu Glu Arg Glu Asp Phe Thr Leu Leu Arg 
            100                 105                 110         


His Tyr Leu Thr Asp Asp Ser Asp Lys Arg Lys Leu Phe Gln Leu Ser 
        115                 120                 125             


Ser Lys Ala Ala Asp Leu Phe Asp Gln Tyr Leu Val Tyr Arg Pro Asp 
    130                 135                 140                 


Trp Leu Ala Gln Trp Glu Thr Gly His Leu Val Glu Gly Leu Gly Glu 
145                 150                 155                 160 


Ala Gln Ala Trp Gln Ala Pro Leu Trp Lys Ala Leu Val Glu Tyr Thr 
                165                 170                 175     


His Gln Leu Gly Gln Pro Arg Trp His Arg Ala Asn Leu Tyr Gln Arg 
            180                 185                 190         


Phe Ile Glu Thr Leu Glu Ser Ala Thr Thr Cys Pro Pro Gly Leu Pro 
        195                 200                 205             


Ser Arg Val Phe Ile Cys Gly Ile Ser Ala Leu Pro Pro Val Tyr Leu 
    210                 215                 220                 


Gln Ala Leu Gln Ala Leu Gly Lys His Ile Glu Ile His Leu Leu Phe 
225                 230                 235                 240 


Thr Asn Pro Cys Arg Tyr Tyr Trp Gly Asp Ile Lys Asp Pro Ala Tyr 
                245                 250                 255     


Leu Ala Lys Leu Leu Thr Arg Gln Arg Arg His Ser Phe Glu Asp Arg 
            260                 265                 270         


Glu Leu Pro Leu Phe Arg Asp Ser Glu Asn Ala Gly Gln Leu Phe Asn 
        275                 280                 285             


Ser Asp Gly Glu Gln Asp Val Gly Asn Pro Leu Leu Ala Ser Trp Gly 
    290                 295                 300                 


Lys Leu Gly Arg Asp Tyr Ile Tyr Leu Leu Ser Asp Leu Glu Ser Ser 
305                 310                 315                 320 


Gln Glu Leu Asp Ala Phe Val Asp Val Thr Pro Asp Asn Leu Leu His 
                325                 330                 335     


Asn Ile Gln Ser Asp Ile Leu Glu Leu Glu Asn Arg Ala Val Ala Gly 
            340                 345                 350         


Val Asn Ile Glu Glu Phe Ser Arg Ser Asp Asn Lys Arg Pro Leu Asp 
        355                 360                 365             


Pro Leu Asp Ser Ser Ile Thr Phe His Val Cys His Ser Pro Gln Arg 
    370                 375                 380                 


Glu Val Glu Val Leu His Asp Arg Leu Leu Ala Met Leu Glu Glu Asp 
385                 390                 395                 400 


Pro Thr Leu Thr Pro Arg Asp Ile Ile Val Met Val Ala Asp Ile Asp 
                405                 410                 415     


Ser Tyr Ser Pro Phe Ile Gln Ala Val Phe Gly Ser Ala Pro Ala Asp 
            420                 425                 430         


Arg Tyr Leu Pro Tyr Ala Ile Ser Asp Arg Arg Ala Arg Gln Ser His 
        435                 440                 445             


Pro Val Leu Glu Ala Phe Ile Ser Leu Leu Ser Leu Pro Asp Ser Arg 
    450                 455                 460                 


Phe Val Ser Glu Asp Val Leu Ala Leu Leu Asp Val Pro Val Leu Ala 
465                 470                 475                 480 


Ala Arg Phe Asp Ile Thr Glu Glu Gly Leu Arg Tyr Leu Arg Gln Trp 
                485                 490                 495     


Val Asn Glu Ser Gly Ile Arg Trp Gly Ile Asp Asp Asp Asn Val Arg 
            500                 505                 510         


Glu Leu Glu Leu Pro Ala Thr Gly Gln His Thr Trp Arg Phe Gly Leu 
        515                 520                 525             


Thr Arg Met Leu Leu Gly Tyr Ala Met Glu Ser Ala Gln Gly Glu Trp 
    530                 535                 540                 


Gln Ser Val Leu Pro Tyr Asp Glu Ser Ser Gly Leu Ile Ala Glu Leu 
545                 550                 555                 560 


Val Gly His Leu Ala Ser Leu Leu Met Gln Leu Asn Ile Trp Arg Arg 
                565                 570                 575     


Gly Leu Ala Gln Glu Arg Pro Leu Glu Glu Trp Leu Pro Val Cys Arg 
            580                 585                 590         


Asp Met Leu Asn Ala Phe Phe Leu Pro Asp Ala Glu Thr Glu Ala Ala 
        595                 600                 605             


Met Thr Leu Ile Glu Gln Gln Trp Gln Ala Ile Ile Ala Glu Gly Leu 
    610                 615                 620                 


Gly Ala Gln Tyr Gly Asp Ala Val Pro Leu Ser Leu Leu Arg Asp Glu 
625                 630                 635                 640 


Leu Ala Gln Arg Leu Asp Gln Glu Arg Ile Ser Gln Arg Phe Leu Ala 
                645                 650                 655     


Gly Pro Val Asn Ile Cys Thr Leu Met Pro Met Arg Ser Ile Pro Phe 
            660                 665                 670         


Lys Val Val Cys Leu Leu Gly Met Asn Asp Gly Val Tyr Pro Arg Gln 
        675                 680                 685             


Leu Ala Pro Leu Gly Phe Asp Leu Met Ser Gln Lys Pro Lys Arg Gly 
    690                 695                 700                 


Asp Arg Ser Arg Arg Asp Asp Asp Arg Tyr Leu Phe Leu Glu Ala Leu 
705                 710                 715                 720 


Ile Ser Ala Gln Gln Lys Leu Tyr Ile Ser Tyr Ile Gly Arg Ser Ile 
                725                 730                 735     


Gln Asp Asn Ser Glu Arg Phe Pro Ser Val Leu Val Gln Glu Leu Ile 
            740                 745                 750         


Asp Tyr Ile Gly Gln Ser His Tyr Leu Pro Gly Asp Glu Ala Leu Asn 
        755                 760                 765             


Cys Asp Glu Ser Glu Ala Arg Val Lys Ala His Leu Thr Cys Leu His 
    770                 775                 780                 


Thr Arg Met Pro Phe Asp Pro Gln Asn Tyr Gln Pro Gly Glu Arg Gln 
785                 790                 795                 800 


Ser Tyr Ala Arg Glu Trp Leu Pro Ala Ala Ser Gln Ala Gly Lys Ala 
                805                 810                 815     


His Ser Glu Phe Val Gln Pro Leu Pro Phe Thr Leu Pro Glu Thr Val 
            820                 825                 830         


Pro Leu Glu Thr Leu Gln Arg Phe Trp Ala His Pro Val Arg Ala Phe 
        835                 840                 845             


Phe Gln Met Arg Leu Gln Val Asn Phe Arg Thr Glu Asp Ser Glu Ile 
    850                 855                 860                 


Pro Asp Thr Glu Pro Phe Ile Leu Glu Gly Leu Ser Arg Tyr Gln Ile 
865                 870                 875                 880 


Asn Gln Gln Leu Leu Asn Ala Leu Val Glu Gln Asp Asp Ala Glu Arg 
                885                 890                 895     


Leu Phe Arg Arg Phe Arg Ala Ala Gly Asp Leu Pro Tyr Gly Ala Phe 
            900                 905                 910         


Gly Glu Ile Phe Trp Glu Thr Gln Cys Gln Glu Met Gln Gln Leu Ala 
        915                 920                 925             


Asp Arg Val Ile Ala Cys Arg Gln Pro Gly Gln Ser Met Glu Ile Asp 
    930                 935                 940                 


Leu Ala Cys Asn Gly Val Gln Ile Thr Gly Trp Leu Pro Gln Val Gln 
945                 950                 955                 960 


Pro Asp Gly Leu Leu Arg Trp Arg Pro Ser Leu Leu Ser Val Ala Gln 
                965                 970                 975     


Gly Met Gln Leu Trp Leu Glu His Leu Val Tyr Cys Ala Ser Gly Gly 
            980                 985                 990         


Asn Gly Glu Ser Arg Leu Phe Leu  Arg Lys Asp Gly Glu  Trp Arg Phe 
        995                 1000                 1005             


Pro Pro  Leu Ala Ala Glu Gln  Ala Leu His Tyr Leu  Ser Gln Leu 
    1010                 1015                 1020             


Ile Glu  Gly Tyr Arg Glu Gly  Met Ser Ala Pro Leu  Leu Val Leu 
    1025                 1030                 1035             


Pro Glu  Ser Gly Gly Ala Trp  Leu Lys Thr Cys Tyr  Asp Ala Gln 
    1040                 1045                 1050             


Asn Asp  Ala Met Leu Asp Asp  Asp Ser Thr Leu Gln  Lys Ala Arg 
    1055                 1060                 1065             


Thr Lys  Phe Leu Gln Ala Tyr  Glu Gly Asn Met Met  Val Arg Gly 
    1070                 1075                 1080             


Glu Gly  Asp Asp Ile Trp Tyr  Gln Arg Leu Trp Arg  Gln Leu Thr 
    1085                 1090                 1095             


Pro Glu  Thr Met Glu Ala Ile  Val Glu Gln Ser Gln  Arg Phe Leu 
    1100                 1105                 1110             


Leu Pro  Leu Phe Arg Phe Asn  Gln Ser 
    1115                 1120         


<210> 41
<211> 608
<212> PRT
<213> Escherichia coli

<400> 41
Met Lys Leu Gln Lys Gln Leu Leu Glu Ala Val Glu His Lys Gln Leu 
1               5                   10                  15      


Arg Pro Leu Asp Val Gln Phe Ala Leu Thr Val Ala Gly Asp Glu His 
            20                  25                  30          


Pro Ala Val Thr Leu Ala Ala Ala Leu Leu Ser His Asp Ala Gly Glu 
        35                  40                  45              


Gly His Val Cys Leu Pro Leu Ser Arg Leu Glu Asn Asn Glu Ala Ser 
    50                  55                  60                  


His Pro Leu Leu Ala Thr Cys Val Ser Glu Ile Gly Glu Leu Gln Asn 
65                  70                  75                  80  


Trp Glu Glu Cys Leu Leu Ala Ser Gln Ala Val Ser Arg Gly Asp Glu 
                85                  90                  95      


Pro Thr Pro Met Ile Leu Cys Gly Asp Arg Leu Tyr Leu Asn Arg Met 
            100                 105                 110         


Trp Cys Asn Glu Arg Thr Val Ala Arg Phe Phe Asn Glu Val Asn His 
        115                 120                 125             


Ala Ile Glu Val Asp Glu Ala Leu Leu Ala Gln Thr Leu Asp Lys Leu 
    130                 135                 140                 


Phe Pro Val Ser Asp Glu Ile Asn Trp Gln Lys Val Ala Ala Ala Val 
145                 150                 155                 160 


Ala Leu Thr Arg Arg Ile Ser Val Ile Ser Gly Gly Pro Gly Thr Gly 
                165                 170                 175     


Lys Thr Thr Thr Val Ala Lys Leu Leu Ala Ala Leu Ile Gln Met Ala 
            180                 185                 190         


Asp Gly Glu Arg Cys Arg Ile Arg Leu Ala Ala Pro Thr Gly Lys Ala 
        195                 200                 205             


Ala Ala Arg Leu Thr Glu Ser Leu Gly Lys Ala Leu Arg Gln Leu Pro 
    210                 215                 220                 


Leu Thr Asp Glu Gln Lys Lys Arg Ile Pro Glu Asp Ala Ser Thr Leu 
225                 230                 235                 240 


His Arg Leu Leu Gly Ala Gln Pro Gly Ser Gln Arg Leu Arg His His 
                245                 250                 255     


Ala Gly Asn Pro Leu His Leu Asp Val Leu Val Val Asp Glu Ala Ser 
            260                 265                 270         


Met Ile Asp Leu Pro Met Met Ser Arg Leu Ile Asp Ala Leu Pro Asp 
        275                 280                 285             


His Ala Arg Val Ile Phe Leu Gly Asp Arg Asp Gln Leu Ala Ser Val 
    290                 295                 300                 


Glu Ala Gly Ala Val Leu Gly Asp Ile Cys Ala Tyr Ala Asn Ala Gly 
305                 310                 315                 320 


Phe Thr Ala Glu Arg Ala Arg Gln Leu Ser Arg Leu Thr Gly Thr His 
                325                 330                 335     


Val Pro Ala Gly Thr Gly Thr Glu Ala Ala Ser Leu Arg Asp Ser Leu 
            340                 345                 350         


Cys Leu Leu Gln Lys Ser Tyr Arg Phe Gly Ser Asp Ser Gly Ile Gly 
        355                 360                 365             


Gln Leu Ala Ala Ala Ile Asn Arg Gly Asp Lys Thr Ala Val Lys Thr 
    370                 375                 380                 


Val Phe Gln Gln Asp Phe Thr Asp Ile Glu Lys Arg Leu Leu Gln Ser 
385                 390                 395                 400 


Gly Glu Asp Tyr Ile Ala Met Leu Glu Glu Ala Leu Ala Gly Tyr Gly 
                405                 410                 415     


Arg Tyr Leu Asp Leu Leu Gln Ala Arg Ala Glu Pro Asp Leu Ile Ile 
            420                 425                 430         


Gln Ala Phe Asn Glu Tyr Gln Leu Leu Cys Ala Leu Arg Glu Gly Pro 
        435                 440                 445             


Phe Gly Val Ala Gly Leu Asn Glu Arg Ile Glu Gln Phe Met Gln Gln 
    450                 455                 460                 


Lys Arg Lys Ile His Arg His Pro His Ser Arg Trp Tyr Glu Gly Arg 
465                 470                 475                 480 


Pro Val Met Ile Ala Arg Asn Asp Ser Ala Leu Gly Leu Phe Asn Gly 
                485                 490                 495     


Asp Ile Gly Ile Ala Leu Asp Arg Gly Gln Gly Thr Arg Val Trp Phe 
            500                 505                 510         


Ala Met Pro Asp Gly Asn Ile Lys Ser Val Gln Pro Ser Arg Leu Pro 
        515                 520                 525             


Glu His Glu Thr Thr Trp Ala Met Thr Val His Lys Ser Gln Gly Ser 
    530                 535                 540                 


Glu Phe Asp His Ala Ala Leu Ile Leu Pro Ser Gln Arg Thr Pro Val 
545                 550                 555                 560 


Val Thr Arg Glu Leu Val Tyr Thr Ala Val Thr Arg Ala Arg Arg Arg 
                565                 570                 575     


Leu Ser Leu Tyr Ala Asp Glu Arg Ile Leu Ser Ala Ala Ile Ala Thr 
            580                 585                 590         


Arg Thr Glu Arg Arg Ser Gly Leu Ala Ala Leu Phe Ser Ser Arg Glu 
        595                 600                 605             


<210> 42
<211> 609
<212> PRT
<213> Escherichia coli

<400> 42
Met Ala Gln Ala Glu Val Leu Asn Leu Glu Ser Gly Ala Lys Gln Val 
1               5                   10                  15      


Leu Gln Glu Thr Phe Gly Tyr Gln Gln Phe Arg Pro Gly Gln Glu Glu 
            20                  25                  30          


Ile Ile Asp Thr Val Leu Ser Gly Arg Asp Cys Leu Val Val Met Pro 
        35                  40                  45              


Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Ile Pro Ala Leu Leu Leu 
    50                  55                  60                  


Asn Gly Leu Thr Val Val Val Ser Pro Leu Ile Ser Leu Met Lys Asp 
65                  70                  75                  80  


Gln Val Asp Gln Leu Gln Ala Asn Gly Val Ala Ala Ala Cys Leu Asn 
                85                  90                  95      


Ser Thr Gln Thr Arg Glu Gln Gln Leu Glu Val Met Thr Gly Cys Arg 
            100                 105                 110         


Thr Gly Gln Ile Arg Leu Leu Tyr Ile Ala Pro Glu Arg Leu Met Leu 
        115                 120                 125             


Asp Asn Phe Leu Glu His Leu Ala His Trp Asn Pro Val Leu Leu Ala 
    130                 135                 140                 


Val Asp Glu Ala His Cys Ile Ser Gln Trp Gly His Asp Phe Arg Pro 
145                 150                 155                 160 


Glu Tyr Ala Ala Leu Gly Gln Leu Arg Gln Arg Phe Pro Thr Leu Pro 
                165                 170                 175     


Phe Met Ala Leu Thr Ala Thr Ala Asp Asp Thr Thr Arg Gln Asp Ile 
            180                 185                 190         


Val Arg Leu Leu Gly Leu Asn Asp Pro Leu Ile Gln Ile Ser Ser Phe 
        195                 200                 205             


Asp Arg Pro Asn Ile Arg Tyr Met Leu Met Glu Lys Phe Lys Pro Leu 
    210                 215                 220                 


Asp Gln Leu Met Arg Tyr Val Gln Glu Gln Arg Gly Lys Ser Gly Ile 
225                 230                 235                 240 


Ile Tyr Cys Asn Ser Arg Ala Lys Val Glu Asp Thr Ala Ala Arg Leu 
                245                 250                 255     


Gln Ser Lys Gly Ile Ser Ala Ala Ala Tyr His Ala Gly Leu Glu Asn 
            260                 265                 270         


Asn Val Arg Ala Asp Val Gln Glu Lys Phe Gln Arg Asp Asp Leu Gln 
        275                 280                 285             


Ile Val Val Ala Thr Val Ala Phe Gly Met Gly Ile Asn Lys Pro Asn 
    290                 295                 300                 


Val Arg Phe Val Val His Phe Asp Ile Pro Arg Asn Ile Glu Ser Tyr 
305                 310                 315                 320 


Tyr Gln Glu Thr Gly Arg Ala Gly Arg Asp Gly Leu Pro Ala Glu Ala 
                325                 330                 335     


Met Leu Phe Tyr Asp Pro Ala Asp Met Ala Trp Leu Arg Arg Cys Leu 
            340                 345                 350         


Glu Glu Lys Pro Gln Gly Gln Leu Gln Asp Ile Glu Arg His Lys Leu 
        355                 360                 365             


Asn Ala Met Gly Ala Phe Ala Glu Ala Gln Thr Cys Arg Arg Leu Val 
    370                 375                 380                 


Leu Leu Asn Tyr Phe Gly Glu Gly Arg Gln Glu Pro Cys Gly Asn Cys 
385                 390                 395                 400 


Asp Ile Cys Leu Asp Pro Pro Lys Gln Tyr Asp Gly Ser Thr Asp Ala 
                405                 410                 415     


Gln Ile Ala Leu Ser Thr Ile Gly Arg Val Asn Gln Arg Phe Gly Met 
            420                 425                 430         


Gly Tyr Val Val Glu Val Ile Arg Gly Ala Asn Asn Gln Arg Ile Arg 
        435                 440                 445             


Asp Tyr Gly His Asp Lys Leu Lys Val Tyr Gly Met Gly Arg Asp Lys 
    450                 455                 460                 


Ser His Glu His Trp Val Ser Val Ile Arg Gln Leu Ile His Leu Gly 
465                 470                 475                 480 


Leu Val Thr Gln Asn Ile Ala Gln His Ser Ala Leu Gln Leu Thr Glu 
                485                 490                 495     


Ala Ala Arg Pro Val Leu Arg Gly Glu Ser Ser Leu Gln Leu Ala Val 
            500                 505                 510         


Pro Arg Ile Val Ala Leu Lys Pro Lys Ala Met Gln Lys Ser Phe Gly 
        515                 520                 525             


Gly Asn Tyr Asp Arg Lys Leu Phe Ala Lys Leu Arg Lys Leu Arg Lys 
    530                 535                 540                 


Ser Ile Ala Asp Glu Ser Asn Val Pro Pro Tyr Val Val Phe Asn Asp 
545                 550                 555                 560 


Ala Thr Leu Ile Glu Met Ala Glu Gln Met Pro Ile Thr Ala Ser Glu 
                565                 570                 575     


Met Leu Ser Val Asn Gly Val Gly Met Arg Lys Leu Glu Arg Phe Gly 
            580                 585                 590         


Lys Pro Phe Met Ala Leu Ile Arg Ala His Val Asp Gly Asp Asp Glu 
        595                 600                 605             


Glu 
    


<210> 43
<211> 508
<212> PRT
<213> Escherichia coli

<400> 43
Met Arg Leu Asn Pro Gly Gln Gln Gln Ala Val Glu Phe Val Thr Gly 
1               5                   10                  15      


Pro Cys Leu Val Leu Ala Gly Ala Gly Ser Gly Lys Thr Arg Val Ile 
            20                  25                  30          


Thr Asn Lys Ile Ala His Leu Ile Arg Gly Cys Gly Tyr Gln Ala Arg 
        35                  40                  45              


His Ile Ala Ala Val Thr Phe Thr Asn Lys Ala Ala Arg Glu Met Lys 
    50                  55                  60                  


Glu Arg Val Gly Gln Thr Leu Gly Arg Lys Glu Ala Arg Gly Leu Met 
65                  70                  75                  80  


Ile Ser Thr Phe His Thr Leu Gly Leu Asp Ile Ile Lys Arg Glu Tyr 
                85                  90                  95      


Ala Ala Leu Gly Met Lys Ala Asn Phe Ser Leu Phe Asp Asp Thr Asp 
            100                 105                 110         


Gln Leu Ala Leu Leu Lys Glu Leu Thr Glu Gly Leu Ile Glu Asp Asp 
        115                 120                 125             


Lys Val Leu Leu Gln Gln Leu Ile Ser Thr Ile Ser Asn Trp Lys Asn 
    130                 135                 140                 


Asp Leu Lys Thr Pro Ala Gln Ala Ala Ala Glu Ala Lys Gly Glu Arg 
145                 150                 155                 160 


Asp Arg Ile Phe Ala His Cys Tyr Gly Leu Tyr Asp Ala His Leu Lys 
                165                 170                 175     


Ala Cys Asn Val Leu Asp Phe Asp Asp Leu Ile Leu Leu Pro Thr Leu 
            180                 185                 190         


Leu Leu Gln Arg Asn Glu Glu Val Arg Glu Arg Trp Gln Asn Lys Ile 
        195                 200                 205             


Arg Tyr Leu Leu Val Asp Glu Tyr Gln Asp Thr Asn Thr Ser Gln Tyr 
    210                 215                 220                 


Glu Leu Val Lys Leu Leu Val Gly Ser Arg Ala Arg Phe Thr Val Val 
225                 230                 235                 240 


Gly Asp Asp Asp Gln Ser Ile Tyr Ser Trp Arg Gly Ala Arg Pro Gln 
                245                 250                 255     


Asn Leu Val Leu Leu Ser Gln Asp Phe Pro Ala Leu Lys Val Ile Lys 
            260                 265                 270         


Leu Glu Gln Asn Tyr Arg Ser Ser Gly Arg Ile Leu Lys Ala Ala Asn 
        275                 280                 285             


Ile Leu Ile Ala Asn Asn Pro His Val Phe Glu Lys Arg Leu Phe Ser 
    290                 295                 300                 


Glu Leu Gly Tyr Gly Thr Glu Leu Lys Val Leu Ser Ala Asn Asn Glu 
305                 310                 315                 320 


Glu His Glu Ala Glu Arg Val Thr Gly Glu Leu Ile Ala His His Phe 
                325                 330                 335     


Val Asn Lys Thr Gln Tyr Lys Asp Tyr Ala Ile Leu Tyr Arg Gly Asn 
            340                 345                 350         


His Gln Ser Arg Val Phe Glu Lys Phe Leu Met Gln Asn Arg Ile Pro 
        355                 360                 365             


Tyr Lys Ile Ser Gly Gly Gly Gly Gly Gly Glu Ser Glu Glu Glu Leu 
    370                 375                 380                 


Asp Gln Val Gln Leu Met Thr Leu His Ala Ser Lys Gly Leu Glu Phe 
385                 390                 395                 400 


Pro Tyr Val Tyr Met Val Gly Met Glu Glu Gly Phe Leu Pro His Gln 
                405                 410                 415     


Ser Ser Ile Asp Glu Asp Asn Ile Asp Glu Glu Arg Arg Leu Ala Tyr 
            420                 425                 430         


Val Gly Ile Thr Arg Ala Gln Lys Glu Leu Thr Phe Thr Leu Cys Lys 
        435                 440                 445             


Glu Arg Arg Gln Tyr Gly Glu Leu Val Arg Pro Glu Pro Ser Arg Phe 
    450                 455                 460                 


Leu Leu Glu Leu Pro Gln Asp Asp Leu Ile Trp Glu Gln Glu Arg Lys 
465                 470                 475                 480 


Val Val Ser Ala Glu Glu Arg Met Gln Lys Gly Gln Ser His Leu Ala 
                485                 490                 495     


Asn Leu Lys Ala Met Met Ala Ala Lys Arg Gly Lys 
            500                 505             


<210> 44
<211> 720
<212> PRT
<213> Escherichia coli

<400> 44
Met Asp Val Ser Tyr Leu Leu Asp Ser Leu Asn Asp Lys Gln Arg Glu 
1               5                   10                  15      


Ala Val Ala Ala Pro Arg Ser Asn Leu Leu Val Leu Ala Gly Ala Gly 
            20                  25                  30          


Ser Gly Lys Thr Arg Val Leu Val His Arg Ile Ala Trp Leu Met Ser 
        35                  40                  45              


Val Glu Asn Cys Ser Pro Tyr Ser Ile Met Ala Val Thr Phe Thr Asn 
    50                  55                  60                  


Lys Ala Ala Ala Glu Met Arg His Arg Ile Gly Gln Leu Met Gly Thr 
65                  70                  75                  80  


Ser Gln Gly Gly Met Trp Val Gly Thr Phe His Gly Leu Ala His Arg 
                85                  90                  95      


Leu Leu Arg Ala His His Met Asp Ala Asn Leu Pro Gln Asp Phe Gln 
            100                 105                 110         


Ile Leu Asp Ser Glu Asp Gln Leu Arg Leu Leu Lys Arg Leu Ile Lys 
        115                 120                 125             


Ala Met Asn Leu Asp Glu Lys Gln Trp Pro Pro Arg Gln Ala Met Trp 
    130                 135                 140                 


Tyr Ile Asn Ser Gln Lys Asp Glu Gly Leu Arg Pro His His Ile Gln 
145                 150                 155                 160 


Ser Tyr Gly Asn Pro Val Glu Gln Thr Trp Gln Lys Val Tyr Gln Ala 
                165                 170                 175     


Tyr Gln Glu Ala Cys Asp Arg Ala Gly Leu Val Asp Phe Ala Glu Leu 
            180                 185                 190         


Leu Leu Arg Ala His Glu Leu Trp Leu Asn Lys Pro His Ile Leu Gln 
        195                 200                 205             


His Tyr Arg Glu Arg Phe Thr Asn Ile Leu Val Asp Glu Phe Gln Asp 
    210                 215                 220                 


Thr Asn Asn Ile Gln Tyr Ala Trp Ile Arg Leu Leu Ala Gly Asp Thr 
225                 230                 235                 240 


Gly Lys Val Met Ile Val Gly Asp Asp Asp Gln Ser Ile Tyr Gly Trp 
                245                 250                 255     


Arg Gly Ala Gln Val Glu Asn Ile Gln Arg Phe Leu Asn Asp Phe Pro 
            260                 265                 270         


Gly Ala Glu Thr Ile Arg Leu Glu Gln Asn Tyr Arg Ser Thr Ser Asn 
        275                 280                 285             


Ile Leu Ser Ala Ala Asn Ala Leu Ile Glu Asn Asn Asn Gly Arg Leu 
    290                 295                 300                 


Gly Lys Lys Leu Trp Thr Asp Gly Ala Asp Gly Glu Pro Ile Ser Leu 
305                 310                 315                 320 


Tyr Cys Ala Phe Asn Glu Leu Asp Glu Ala Arg Phe Val Val Asn Arg 
                325                 330                 335     


Ile Lys Thr Trp Gln Asp Asn Gly Gly Ala Leu Ala Glu Cys Ala Ile 
            340                 345                 350         


Leu Tyr Arg Ser Asn Ala Gln Ser Arg Val Leu Glu Glu Ala Leu Leu 
        355                 360                 365             


Gln Ala Ser Met Pro Tyr Arg Ile Tyr Gly Gly Met Arg Phe Phe Glu 
    370                 375                 380                 


Arg Gln Glu Ile Lys Asp Ala Leu Ser Tyr Leu Arg Leu Ile Ala Asn 
385                 390                 395                 400 


Arg Asn Asp Asp Ala Ala Phe Glu Arg Val Val Asn Thr Pro Thr Arg 
                405                 410                 415     


Gly Ile Gly Asp Arg Thr Leu Asp Val Val Arg Gln Thr Ser Arg Asp 
            420                 425                 430         


Arg Gln Leu Thr Leu Trp Gln Ala Cys Arg Glu Leu Leu Gln Glu Lys 
        435                 440                 445             


Ala Leu Ala Gly Arg Ala Ala Ser Ala Leu Gln Arg Phe Met Glu Leu 
    450                 455                 460                 


Ile Asp Ala Leu Ala Gln Glu Thr Ala Asp Met Pro Leu His Val Gln 
465                 470                 475                 480 


Thr Asp Arg Val Ile Lys Asp Ser Gly Leu Arg Thr Met Tyr Glu Gln 
                485                 490                 495     


Glu Lys Gly Glu Lys Gly Gln Thr Arg Ile Glu Asn Leu Glu Glu Leu 
            500                 505                 510         


Val Thr Ala Thr Arg Gln Phe Ser Tyr Asn Glu Glu Asp Glu Asp Leu 
        515                 520                 525             


Met Pro Leu Gln Ala Phe Leu Ser His Ala Ala Leu Glu Ala Gly Glu 
    530                 535                 540                 


Gly Gln Ala Asp Thr Trp Gln Asp Ala Val Gln Leu Met Thr Leu His 
545                 550                 555                 560 


Ser Ala Lys Gly Leu Glu Phe Pro Gln Val Phe Ile Val Gly Met Glu 
                565                 570                 575     


Glu Gly Met Phe Pro Ser Gln Met Ser Leu Asp Glu Gly Gly Arg Leu 
            580                 585                 590         


Glu Glu Glu Arg Arg Leu Ala Tyr Val Gly Val Thr Arg Ala Met Gln 
        595                 600                 605             


Lys Leu Thr Leu Thr Tyr Ala Glu Thr Arg Arg Leu Tyr Gly Lys Glu 
    610                 615                 620                 


Val Tyr His Arg Pro Ser Arg Phe Ile Gly Glu Leu Pro Glu Glu Cys 
625                 630                 635                 640 


Val Glu Glu Val Arg Leu Arg Ala Thr Val Ser Arg Pro Val Ser His 
                645                 650                 655     


Gln Arg Met Gly Thr Pro Met Val Glu Asn Asp Ser Gly Tyr Lys Leu 
            660                 665                 670         


Gly Gln Arg Val Arg His Ala Lys Phe Gly Glu Gly Thr Ile Val Asn 
        675                 680                 685             


Met Glu Gly Ser Gly Glu His Ser Arg Leu Gln Val Ala Phe Gln Gly 
    690                 695                 700                 


Gln Gly Ile Lys Trp Leu Val Ala Ala Tyr Ala Arg Leu Glu Ser Val 
705                 710                 715                 720 


<210> 45
<211> 968
<212> PRT
<213> Escherichia coli

<400> 45
Met Pro Phe Thr Leu Gly Gln Arg Trp Ile Ser Asp Thr Glu Ser Glu 
1               5                   10                  15      


Leu Gly Leu Gly Thr Val Val Ala Val Asp Ala Arg Thr Val Thr Leu 
            20                  25                  30          


Leu Phe Pro Ser Thr Gly Glu Asn Arg Leu Tyr Ala Arg Ser Asp Ser 
        35                  40                  45              


Pro Val Thr Arg Val Met Phe Asn Pro Gly Asp Thr Ile Thr Ser His 
    50                  55                  60                  


Asp Gly Trp Gln Met Gln Val Glu Glu Val Lys Glu Glu Asn Gly Leu 
65                  70                  75                  80  


Leu Thr Tyr Ile Gly Thr Arg Leu Asp Thr Glu Glu Ser Gly Val Ala 
                85                  90                  95      


Leu Arg Glu Val Phe Leu Asp Ser Lys Leu Val Phe Ser Lys Pro Gln 
            100                 105                 110         


Asp Arg Leu Phe Ala Gly Gln Ile Asp Arg Met Asp Arg Phe Ala Leu 
        115                 120                 125             


Arg Tyr Arg Ala Arg Lys Tyr Ser Ser Glu Gln Phe Arg Met Pro Tyr 
    130                 135                 140                 


Ser Gly Leu Arg Gly Gln Arg Thr Ser Leu Ile Pro His Gln Leu Asn 
145                 150                 155                 160 


Ile Ala His Asp Val Gly Arg Arg His Ala Pro Arg Val Leu Leu Ala 
                165                 170                 175     


Asp Glu Val Gly Leu Gly Lys Thr Ile Glu Ala Gly Met Ile Leu His 
            180                 185                 190         


Gln Gln Leu Leu Ser Gly Ala Ala Glu Arg Val Leu Ile Ile Val Pro 
        195                 200                 205             


Glu Thr Leu Gln His Gln Trp Leu Val Glu Met Leu Arg Arg Phe Asn 
    210                 215                 220                 


Leu Arg Phe Ala Leu Phe Asp Asp Glu Arg Tyr Ala Glu Ala Gln His 
225                 230                 235                 240 


Asp Ala Tyr Asn Pro Phe Asp Thr Glu Gln Leu Val Ile Cys Ser Leu 
                245                 250                 255     


Asp Phe Ala Arg Arg Ser Lys Gln Arg Leu Glu His Leu Cys Glu Ala 
            260                 265                 270         


Glu Trp Asp Leu Leu Val Val Asp Glu Ala His His Leu Val Trp Ser 
        275                 280                 285             


Glu Asp Ala Pro Ser Arg Glu Tyr Gln Ala Ile Glu Gln Leu Ala Glu 
    290                 295                 300                 


His Val Pro Gly Val Leu Leu Leu Thr Ala Thr Pro Glu Gln Leu Gly 
305                 310                 315                 320 


Met Glu Ser His Phe Ala Arg Leu Arg Leu Leu Asp Pro Asn Arg Phe 
                325                 330                 335     


His Asp Phe Ala Gln Phe Val Glu Glu Gln Lys Asn Tyr Arg Pro Val 
            340                 345                 350         


Ala Asp Ala Val Ala Met Leu Leu Ala Gly Asn Lys Leu Ser Asn Asp 
        355                 360                 365             


Glu Leu Asn Met Leu Gly Glu Met Ile Gly Glu Gln Asp Ile Glu Pro 
    370                 375                 380                 


Leu Leu Gln Ala Ala Asn Ser Asp Ser Glu Asp Ala Gln Ser Ala Arg 
385                 390                 395                 400 


Gln Glu Leu Val Ser Met Leu Met Asp Arg His Gly Thr Ser Arg Val 
                405                 410                 415     


Leu Phe Arg Asn Thr Arg Asn Gly Val Lys Gly Phe Pro Lys Arg Glu 
            420                 425                 430         


Leu His Thr Ile Lys Leu Pro Leu Pro Thr Gln Tyr Gln Thr Ala Ile 
        435                 440                 445             


Lys Val Ser Gly Ile Met Gly Ala Arg Lys Ser Ala Glu Asp Arg Ala 
    450                 455                 460                 


Arg Asp Met Leu Tyr Pro Glu Arg Ile Tyr Gln Glu Phe Glu Gly Asp 
465                 470                 475                 480 


Asn Ala Thr Trp Trp Asn Phe Asp Pro Arg Val Glu Trp Leu Met Gly 
                485                 490                 495     


Tyr Leu Thr Ser His Arg Ser Gln Lys Val Leu Val Ile Cys Ala Lys 
            500                 505                 510         


Ala Ala Thr Ala Leu Gln Leu Glu Gln Val Leu Arg Glu Arg Glu Gly 
        515                 520                 525             


Ile Arg Ala Ala Val Phe His Glu Gly Met Ser Ile Ile Glu Arg Asp 
    530                 535                 540                 


Arg Ala Ala Ala Trp Phe Ala Glu Glu Asp Thr Gly Ala Gln Val Leu 
545                 550                 555                 560 


Leu Cys Ser Glu Ile Gly Ser Glu Gly Arg Asn Phe Gln Phe Ala Ser 
                565                 570                 575     


His Met Val Met Phe Asp Leu Pro Phe Asn Pro Asp Leu Leu Glu Gln 
            580                 585                 590         


Arg Ile Gly Arg Leu Asp Arg Ile Gly Gln Ala His Asp Ile Gln Ile 
        595                 600                 605             


His Val Pro Tyr Leu Glu Lys Thr Ala Gln Ser Val Leu Val Arg Trp 
    610                 615                 620                 


Tyr His Glu Gly Leu Asp Ala Phe Glu His Thr Cys Pro Thr Gly Arg 
625                 630                 635                 640 


Thr Ile Tyr Asp Ser Val Tyr Asn Asp Leu Ile Asn Tyr Leu Ala Ser 
                645                 650                 655     


Pro Asp Gln Thr Glu Gly Phe Asp Asp Leu Ile Lys Asn Cys Arg Glu 
            660                 665                 670         


Gln His Glu Ala Leu Lys Ala Gln Leu Glu Gln Gly Arg Asp Arg Leu 
        675                 680                 685             


Leu Glu Ile His Ser Asn Gly Gly Glu Lys Ala Gln Ala Leu Ala Glu 
    690                 695                 700                 


Ser Ile Glu Glu Gln Asp Asp Asp Thr Asn Leu Ile Ala Phe Ala Met 
705                 710                 715                 720 


Asn Leu Phe Asp Ile Ile Gly Ile Asn Gln Asp Asp Arg Gly Asp Asn 
                725                 730                 735     


Met Ile Val Leu Thr Pro Ser Asp His Met Leu Val Pro Asp Phe Pro 
            740                 745                 750         


Gly Leu Ser Glu Asp Gly Ile Thr Ile Thr Phe Asp Arg Glu Val Ala 
        755                 760                 765             


Leu Ala Arg Glu Asp Ala Gln Phe Ile Thr Trp Glu His Pro Leu Ile 
    770                 775                 780                 


Arg Asn Gly Leu Asp Leu Ile Leu Ser Gly Asp Thr Gly Ser Ser Thr 
785                 790                 795                 800 


Ile Ser Leu Leu Lys Asn Lys Ala Leu Pro Val Gly Thr Leu Leu Val 
                805                 810                 815     


Glu Leu Ile Tyr Val Val Glu Ala Gln Ala Pro Lys Gln Leu Gln Leu 
            820                 825                 830         


Asn Arg Phe Leu Pro Pro Thr Pro Val Arg Met Leu Leu Asp Lys Asn 
        835                 840                 845             


Gly Asn Asn Leu Ala Ala Gln Val Glu Phe Glu Thr Phe Asn Arg Gln 
    850                 855                 860                 


Leu Asn Ala Val Asn Arg His Thr Gly Ser Lys Leu Val Asn Ala Val 
865                 870                 875                 880 


Gln Gln Asp Val His Ala Ile Leu Gln Leu Gly Glu Ala Gln Ile Glu 
                885                 890                 895     


Lys Ser Ala Arg Ala Leu Ile Asp Ala Ala Arg Asn Glu Ala Asp Glu 
            900                 905                 910         


Lys Leu Ser Ala Glu Leu Ser Arg Leu Glu Ala Leu Arg Ala Val Asn 
        915                 920                 925             


Pro Asn Ile Arg Asp Asp Glu Leu Thr Ala Ile Glu Ser Asn Arg Gln 
    930                 935                 940                 


Gln Val Met Glu Ser Leu Asp Gln Ala Gly Trp Arg Leu Asp Ala Leu 
945                 950                 955                 960 


Arg Leu Ile Val Val Thr His Gln 
                965             


<210> 46
<211> 693
<212> PRT
<213> Escherichia coli

<400> 46
Met Lys Gly Arg Leu Leu Asp Ala Val Pro Leu Ser Ser Leu Thr Gly 
1               5                   10                  15      


Val Gly Ala Ala Leu Ser Asn Lys Leu Ala Lys Ile Asn Leu His Thr 
            20                  25                  30          


Val Gln Asp Leu Leu Leu His Leu Pro Leu Arg Tyr Glu Asp Arg Thr 
        35                  40                  45              


His Leu Tyr Pro Ile Gly Glu Leu Leu Pro Gly Val Tyr Ala Thr Val 
    50                  55                  60                  


Glu Gly Glu Val Leu Asn Cys Asn Ile Ser Phe Gly Gly Arg Arg Met 
65                  70                  75                  80  


Met Thr Cys Gln Ile Ser Asp Gly Ser Gly Ile Leu Thr Met Arg Phe 
                85                  90                  95      


Phe Asn Phe Ser Ala Ala Met Lys Asn Ser Leu Ala Ala Gly Arg Arg 
            100                 105                 110         


Val Leu Ala Tyr Gly Glu Ala Lys Arg Gly Lys Tyr Gly Ala Glu Met 
        115                 120                 125             


Ile His Pro Glu Tyr Arg Val Gln Gly Asp Leu Ser Thr Pro Glu Leu 
    130                 135                 140                 


Gln Glu Thr Leu Thr Pro Val Tyr Pro Thr Thr Glu Gly Val Lys Gln 
145                 150                 155                 160 


Ala Thr Leu Arg Lys Leu Thr Asp Gln Ala Leu Asp Leu Leu Asp Thr 
                165                 170                 175     


Cys Ala Ile Glu Glu Leu Leu Pro Pro Glu Leu Ser Gln Gly Met Met 
            180                 185                 190         


Thr Leu Pro Glu Ala Leu Arg Thr Leu His Arg Pro Pro Pro Thr Leu 
        195                 200                 205             


Gln Leu Ser Asp Leu Glu Thr Gly Gln His Pro Ala Gln Arg Arg Leu 
    210                 215                 220                 


Ile Leu Glu Glu Leu Leu Ala His Asn Leu Ser Met Leu Ala Leu Arg 
225                 230                 235                 240 


Ala Gly Ala Gln Arg Phe His Ala Gln Pro Leu Ser Ala Asn Asp Thr 
                245                 250                 255     


Leu Lys Asn Lys Leu Leu Ala Ala Leu Pro Phe Lys Pro Thr Gly Ala 
            260                 265                 270         


Gln Ala Arg Val Val Ala Glu Ile Glu Arg Asp Met Ala Leu Asp Val 
        275                 280                 285             


Pro Met Met Arg Leu Val Gln Gly Asp Val Gly Ser Gly Lys Thr Leu 
    290                 295                 300                 


Val Ala Ala Leu Ala Ala Leu Arg Ala Ile Ala His Gly Lys Gln Val 
305                 310                 315                 320 


Ala Leu Met Ala Pro Thr Glu Leu Leu Ala Glu Gln His Ala Asn Asn 
                325                 330                 335     


Phe Arg Asn Trp Phe Ala Pro Leu Gly Ile Glu Val Gly Trp Leu Ala 
            340                 345                 350         


Gly Lys Gln Lys Gly Lys Ala Arg Leu Ala Gln Gln Glu Ala Ile Ala 
        355                 360                 365             


Ser Gly Gln Val Gln Met Ile Val Gly Thr His Ala Ile Phe Gln Glu 
    370                 375                 380                 


Gln Val Gln Phe Asn Gly Leu Ala Leu Val Ile Ile Asp Glu Gln His 
385                 390                 395                 400 


Arg Phe Gly Val His Gln Arg Leu Ala Leu Trp Glu Lys Gly Gln Gln 
                405                 410                 415     


Gln Gly Phe His Pro His Gln Leu Ile Met Thr Ala Thr Pro Ile Pro 
            420                 425                 430         


Arg Thr Leu Ala Met Thr Ala Tyr Ala Asp Leu Asp Thr Ser Val Ile 
        435                 440                 445             


Asp Glu Leu Pro Pro Gly Arg Thr Pro Val Thr Thr Val Ala Ile Pro 
    450                 455                 460                 


Asp Thr Arg Arg Thr Asp Ile Ile Asp Arg Val His His Ala Cys Ile 
465                 470                 475                 480 


Thr Glu Gly Arg Gln Ala Tyr Trp Val Cys Thr Leu Ile Glu Glu Ser 
                485                 490                 495     


Glu Leu Leu Glu Ala Gln Ala Ala Glu Ala Thr Trp Glu Glu Leu Lys 
            500                 505                 510         


Leu Ala Leu Pro Glu Leu Asn Val Gly Leu Val His Gly Arg Met Lys 
        515                 520                 525             


Pro Ala Glu Lys Gln Ala Val Met Ala Ser Phe Lys Gln Gly Glu Leu 
    530                 535                 540                 


His Leu Leu Val Ala Thr Thr Val Ile Glu Val Gly Val Asp Val Pro 
545                 550                 555                 560 


Asn Ala Ser Leu Met Ile Ile Glu Asn Pro Glu Arg Leu Gly Leu Ala 
                565                 570                 575     


Gln Leu His Gln Leu Arg Gly Arg Val Gly Arg Gly Ala Val Ala Ser 
            580                 585                 590         


His Cys Val Leu Leu Tyr Lys Thr Pro Leu Ser Lys Thr Ala Gln Ile 
        595                 600                 605             


Arg Leu Gln Val Leu Arg Asp Ser Asn Asp Gly Phe Val Ile Ala Gln 
    610                 615                 620                 


Lys Asp Leu Glu Ile Arg Gly Pro Gly Glu Leu Leu Gly Thr Arg Gln 
625                 630                 635                 640 


Thr Gly Asn Ala Glu Phe Lys Val Ala Asp Leu Leu Arg Asp Gln Ala 
                645                 650                 655     


Met Ile Pro Glu Val Gln Arg Leu Ala Arg His Ile His Glu Arg Tyr 
            660                 665                 670         


Pro Gln Gln Ala Lys Ala Leu Ile Glu Arg Trp Met Pro Glu Thr Glu 
        675                 680                 685             


Arg Tyr Ser Asn Ala 
    690             


<210> 47
<211> 467
<212> PRT
<213> Homo sapiens

<400> 47
Met Ser Leu Ser Leu Trp Gln Gln Cys Leu Ala Arg Leu Gln Asp Glu 
1               5                   10                  15      


Leu Pro Ala Thr Glu Phe Ser Met Trp Ile Arg Pro Leu Gln Ala Glu 
            20                  25                  30          


Leu Ser Asp Asn Thr Leu Ala Leu Tyr Ala Pro Asn Arg Phe Val Leu 
        35                  40                  45              


Asp Trp Val Arg Asp Lys Tyr Leu Asn Asn Ile Asn Gly Leu Leu Thr 
    50                  55                  60                  


Ser Phe Cys Gly Ala Asp Ala Pro Gln Leu Arg Phe Glu Val Gly Thr 
65                  70                  75                  80  


Lys Pro Val Thr Gln Thr Pro Gln Ala Ala Val Thr Ser Asn Val Ala 
                85                  90                  95      


Ala Pro Ala Gln Val Ala Gln Thr Gln Pro Gln Arg Ala Ala Pro Ser 
            100                 105                 110         


Thr Arg Ser Gly Trp Asp Asn Val Pro Ala Pro Ala Glu Pro Thr Tyr 
        115                 120                 125             


Arg Ser Asn Val Asn Val Lys His Thr Phe Asp Asn Phe Val Glu Gly 
    130                 135                 140                 


Lys Ser Asn Gln Leu Ala Arg Ala Ala Ala Arg Gln Val Ala Asp Asn 
145                 150                 155                 160 


Pro Gly Gly Ala Tyr Asn Pro Leu Phe Leu Tyr Gly Gly Thr Gly Leu 
                165                 170                 175     


Gly Lys Thr His Leu Leu His Ala Val Gly Asn Gly Ile Met Ala Arg 
            180                 185                 190         


Lys Pro Asn Ala Lys Val Val Tyr Met His Ser Glu Arg Phe Val Gln 
        195                 200                 205             


Asp Met Val Lys Ala Leu Gln Asn Asn Ala Ile Glu Glu Phe Lys Arg 
    210                 215                 220                 


Tyr Tyr Arg Ser Val Asp Ala Leu Leu Ile Asp Asp Ile Gln Phe Phe 
225                 230                 235                 240 


Ala Asn Lys Glu Arg Ser Gln Glu Glu Phe Phe His Thr Phe Asn Ala 
                245                 250                 255     


Leu Leu Glu Gly Asn Gln Gln Ile Ile Leu Thr Ser Asp Arg Tyr Pro 
            260                 265                 270         


Lys Glu Ile Asn Gly Val Glu Asp Arg Leu Lys Ser Arg Phe Gly Trp 
        275                 280                 285             


Gly Leu Thr Val Ala Ile Glu Pro Pro Glu Leu Glu Thr Arg Val Ala 
    290                 295                 300                 


Ile Leu Met Lys Lys Ala Asp Glu Asn Asp Ile Arg Leu Pro Gly Glu 
305                 310                 315                 320 


Val Ala Phe Phe Ile Ala Lys Arg Leu Arg Ser Asn Val Arg Glu Leu 
                325                 330                 335     


Glu Gly Ala Leu Asn Arg Val Ile Ala Asn Ala Asn Phe Thr Gly Arg 
            340                 345                 350         


Ala Ile Thr Ile Asp Phe Val Arg Glu Ala Leu Arg Asp Leu Leu Ala 
        355                 360                 365             


Leu Gln Glu Lys Leu Val Thr Ile Asp Asn Ile Gln Lys Thr Val Ala 
    370                 375                 380                 


Glu Tyr Tyr Lys Ile Lys Val Ala Asp Leu Leu Ser Lys Arg Arg Ser 
385                 390                 395                 400 


Arg Ser Val Ala Arg Pro Arg Gln Met Ala Met Ala Leu Ala Lys Glu 
                405                 410                 415     


Leu Thr Asn His Ser Leu Pro Glu Ile Gly Asp Ala Phe Gly Gly Arg 
            420                 425                 430         


Asp His Thr Thr Val Leu His Ala Cys Arg Lys Ile Glu Gln Leu Arg 
        435                 440                 445             


Glu Glu Ser His Asp Ile Lys Glu Asp Phe Ser Asn Leu Ile Arg Thr 
    450                 455                 460                 


Leu Ser Ser 
465         


<210> 48
<211> 215
<212> PRT
<213> Homo sapiens

<400> 48
Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210> 49
<211> 209
<212> PRT
<213> Homo sapiens

<400> 49
Met Gly Lys Gly Asp Pro Asn Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ser Ser Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Ser Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ser Asp Lys Ala Arg Tyr Asp Arg Glu Met Lys Asn Tyr Val Pro 
65                  70                  75                  80  


Pro Lys Gly Asp Lys Lys Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu His Arg Pro Lys 
            100                 105                 110         


Ile Lys Ser Glu His Pro Gly Leu Ser Ile Gly Asp Thr Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Ser Glu Gln Ser Ala Lys Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Gln Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Ser Glu Ala Gly Lys Lys Gly Pro Gly 
                165                 170                 175     


Arg Pro Thr Gly Ser Lys Lys Lys Asn Glu Pro Glu Asp Glu Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu 
    


<210> 50
<211> 616
<212> PRT
<213> Homo sapiens

<400> 50
Met Val Gly Gln Leu Ser Glu Gly Ala Ile Ala Ala Ile Met Gln Lys 
1               5                   10                  15      


Gly Asp Thr Asn Ile Lys Pro Ile Leu Gln Val Ile Asn Ile Arg Pro 
            20                  25                  30          


Ile Thr Thr Gly Asn Ser Pro Pro Arg Tyr Arg Leu Leu Met Ser Asp 
        35                  40                  45              


Gly Leu Asn Thr Leu Ser Ser Phe Met Leu Ala Thr Gln Leu Asn Pro 
    50                  55                  60                  


Leu Val Glu Glu Glu Gln Leu Ser Ser Asn Cys Val Cys Gln Ile His 
65                  70                  75                  80  


Arg Phe Ile Val Asn Thr Leu Lys Asp Gly Arg Arg Val Val Ile Leu 
                85                  90                  95      


Met Glu Leu Glu Val Leu Lys Ser Ala Glu Ala Val Gly Val Lys Ile 
            100                 105                 110         


Gly Asn Pro Val Pro Tyr Asn Glu Gly Leu Gly Gln Pro Gln Val Ala 
        115                 120                 125             


Pro Pro Ala Pro Ala Ala Ser Pro Ala Ala Ser Ser Arg Pro Gln Pro 
    130                 135                 140                 


Gln Asn Gly Ser Ser Gly Met Gly Ser Thr Val Ser Lys Ala Tyr Gly 
145                 150                 155                 160 


Ala Ser Lys Thr Phe Gly Lys Ala Ala Gly Pro Ser Leu Ser His Thr 
                165                 170                 175     


Ser Gly Gly Thr Gln Ser Lys Val Val Pro Ile Ala Ser Leu Thr Pro 
            180                 185                 190         


Tyr Gln Ser Lys Trp Thr Ile Cys Ala Arg Val Thr Asn Lys Ser Gln 
        195                 200                 205             


Ile Arg Thr Trp Ser Asn Ser Arg Gly Glu Gly Lys Leu Phe Ser Leu 
    210                 215                 220                 


Glu Leu Val Asp Glu Ser Gly Glu Ile Arg Ala Thr Ala Phe Asn Glu 
225                 230                 235                 240 


Gln Val Asp Lys Phe Phe Pro Leu Ile Glu Val Asn Lys Val Tyr Tyr 
                245                 250                 255     


Phe Ser Lys Gly Thr Leu Lys Ile Ala Asn Lys Gln Phe Thr Ala Val 
            260                 265                 270         


Lys Asn Asp Tyr Glu Met Thr Phe Asn Asn Glu Thr Ser Val Met Pro 
        275                 280                 285             


Cys Glu Asp Asp His His Leu Pro Thr Val Gln Phe Asp Phe Thr Gly 
    290                 295                 300                 


Ile Asp Asp Leu Glu Asn Lys Ser Lys Asp Ser Leu Val Asp Ile Ile 
305                 310                 315                 320 


Gly Ile Cys Lys Ser Tyr Glu Asp Ala Thr Lys Ile Thr Val Arg Ser 
                325                 330                 335     


Asn Asn Arg Glu Val Ala Lys Arg Asn Ile Tyr Leu Met Asp Thr Ser 
            340                 345                 350         


Gly Lys Val Val Thr Ala Thr Leu Trp Gly Glu Asp Ala Asp Lys Phe 
        355                 360                 365             


Asp Gly Ser Arg Gln Pro Val Leu Ala Ile Lys Gly Ala Arg Val Ser 
    370                 375                 380                 


Asp Phe Gly Gly Arg Ser Leu Ser Val Leu Ser Ser Ser Thr Ile Ile 
385                 390                 395                 400 


Ala Asn Pro Asp Ile Pro Glu Ala Tyr Lys Leu Arg Gly Trp Phe Asp 
                405                 410                 415     


Ala Glu Gly Gln Ala Leu Asp Gly Val Ser Ile Ser Asp Leu Lys Ser 
            420                 425                 430         


Gly Gly Val Gly Gly Ser Asn Thr Asn Trp Lys Thr Leu Tyr Glu Val 
        435                 440                 445             


Lys Ser Glu Asn Leu Gly Gln Gly Asp Lys Pro Asp Tyr Phe Ser Ser 
    450                 455                 460                 


Val Ala Thr Val Val Tyr Leu Arg Lys Glu Asn Cys Met Tyr Gln Ala 
465                 470                 475                 480 


Cys Pro Thr Gln Asp Cys Asn Lys Lys Val Ile Asp Gln Gln Asn Gly 
                485                 490                 495     


Leu Tyr Arg Cys Glu Lys Cys Asp Thr Glu Phe Pro Asn Phe Lys Tyr 
            500                 505                 510         


Arg Met Ile Leu Ser Val Asn Ile Ala Asp Phe Gln Glu Asn Gln Trp 
        515                 520                 525             


Val Thr Cys Phe Gln Glu Ser Ala Glu Ala Ile Leu Gly Gln Asn Ala 
    530                 535                 540                 


Ala Tyr Leu Gly Glu Leu Lys Asp Lys Asn Glu Gln Ala Phe Glu Glu 
545                 550                 555                 560 


Val Phe Gln Asn Ala Asn Phe Arg Ser Phe Ile Phe Arg Val Arg Val 
                565                 570                 575     


Lys Val Glu Thr Tyr Asn Asp Glu Ser Arg Ile Lys Ala Thr Val Met 
            580                 585                 590         


Asp Val Lys Pro Val Asp Tyr Arg Glu Tyr Gly Arg Arg Leu Val Met 
        595                 600                 605             


Ser Ile Arg Arg Ser Ala Leu Met 
    610                 615     


<210> 51
<211> 270
<212> PRT
<213> Homo sapiens

<400> 51
Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly 
1               5                   10                  15      


Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro 
            20                  25                  30          


Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro 
        35                  40                  45              


Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe 
    50                  55                  60                  


Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile 
65                  70                  75                  80  


Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp 
                85                  90                  95      


Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp 
            100                 105                 110         


Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val 
        115                 120                 125             


Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe 
    130                 135                 140                 


Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu 
145                 150                 155                 160 


Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro 
                165                 170                 175     


Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly 
            180                 185                 190         


Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala 
        195                 200                 205             


Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly 
    210                 215                 220                 


Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser 
225                 230                 235                 240 


Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr 
                245                 250                 255     


Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu 
            260                 265                 270 


<210> 52
<211> 121
<212> PRT
<213> Homo sapiens

<400> 52
Met Val Asp Met Met Asp Leu Pro Arg Ser Arg Ile Asn Ala Gly Met 
1               5                   10                  15      


Leu Ala Gln Phe Ile Asp Lys Pro Val Cys Phe Val Gly Arg Leu Glu 
            20                  25                  30          


Lys Ile His Pro Thr Gly Lys Met Phe Ile Leu Ser Asp Gly Glu Gly 
        35                  40                  45              


Lys Asn Gly Thr Ile Glu Leu Met Glu Pro Leu Asp Glu Glu Ile Ser 
    50                  55                  60                  


Gly Ile Val Glu Val Val Gly Arg Val Thr Ala Lys Ala Thr Ile Leu 
65                  70                  75                  80  


Cys Thr Ser Tyr Val Gln Phe Lys Glu Asp Ser His Pro Phe Asp Leu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Ala Val Lys Ile Ile His Asp Phe Pro Gln Phe 
            100                 105                 110         


Tyr Pro Leu Gly Ile Val Gln His Asp 
        115                 120     


<210> 53
<211> 339
<212> PRT
<213> Homo sapiens

<400> 53
Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210> 54
<211> 418
<212> PRT
<213> Homo sapiens

<400> 54
Met Ser Gly Thr Glu Glu Ala Ile Leu Gly Gly Arg Asp Ser His Pro 
1               5                   10                  15      


Ala Ala Gly Gly Gly Ser Val Leu Cys Phe Gly Gln Cys Gln Tyr Thr 
            20                  25                  30          


Ala Glu Glu Tyr Gln Ala Ile Gln Lys Ala Leu Arg Gln Arg Leu Gly 
        35                  40                  45              


Pro Glu Tyr Ile Ser Ser Arg Met Ala Gly Gly Gly Gln Lys Val Cys 
    50                  55                  60                  


Tyr Ile Glu Gly His Arg Val Ile Asn Leu Ala Asn Glu Met Phe Gly 
65                  70                  75                  80  


Tyr Asn Gly Trp Ala His Ser Ile Thr Gln Gln Asn Val Asp Phe Val 
                85                  90                  95      


Asp Leu Asn Asn Gly Lys Phe Tyr Val Gly Val Cys Ala Phe Val Arg 
            100                 105                 110         


Val Gln Leu Lys Asp Gly Ser Tyr His Glu Asp Val Gly Tyr Gly Val 
        115                 120                 125             


Ser Glu Gly Leu Lys Ser Lys Ala Leu Ser Leu Glu Lys Ala Arg Lys 
    130                 135                 140                 


Glu Ala Val Thr Asp Gly Leu Lys Arg Ala Leu Arg Ser Phe Gly Asn 
145                 150                 155                 160 


Ala Leu Gly Asn Cys Ile Leu Asp Lys Asp Tyr Leu Arg Ser Leu Asn 
                165                 170                 175     


Lys Leu Pro Arg Gln Leu Pro Leu Glu Val Asp Leu Thr Lys Ala Lys 
            180                 185                 190         


Arg Gln Asp Leu Glu Pro Ser Val Glu Glu Ala Arg Tyr Asn Ser Cys 
        195                 200                 205             


Arg Pro Asn Met Ala Leu Gly His Pro Gln Leu Gln Gln Val Thr Ser 
    210                 215                 220                 


Pro Ser Arg Pro Ser His Ala Val Ile Pro Ala Asp Gln Asp Cys Ser 
225                 230                 235                 240 


Ser Arg Ser Leu Ser Ser Ser Ala Val Glu Ser Glu Ala Thr His Gln 
                245                 250                 255     


Arg Lys Leu Arg Gln Lys Gln Leu Gln Gln Gln Phe Arg Glu Arg Met 
            260                 265                 270         


Glu Lys Gln Gln Val Arg Val Ser Thr Pro Ser Ala Glu Lys Ser Glu 
        275                 280                 285             


Ala Ala Pro Pro Ala Pro Pro Val Thr His Ser Thr Pro Val Thr Val 
    290                 295                 300                 


Ser Glu Pro Leu Leu Glu Lys Asp Phe Leu Ala Gly Val Thr Gln Glu 
305                 310                 315                 320 


Leu Ile Lys Thr Leu Glu Asp Asn Ser Glu Lys Trp Ala Val Thr Pro 
                325                 330                 335     


Asp Ala Gly Asp Gly Val Val Lys Pro Ser Ser Arg Ala Asp Pro Ala 
            340                 345                 350         


Gln Thr Ser Asp Thr Leu Ala Leu Asn Asn Gln Met Val Thr Gln Asn 
        355                 360                 365             


Arg Thr Pro His Ser Val Cys His Gln Lys Pro Gln Ala Lys Ser Gly 
    370                 375                 380                 


Ser Trp Asp Leu Gln Thr Tyr Ser Ala Asp Gln Arg Thr Thr Gly Asn 
385                 390                 395                 400 


Trp Glu Ser His Arg Lys Ser Gln Asp Met Lys Lys Arg Lys Tyr Asp 
                405                 410                 415     


Pro Ser 
        


<210> 55
<211> 1417
<212> PRT
<213> Homo sapiens

<400> 55
Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Gly  Ser Lys Ser Ala Lys  Ile Gln Ser 
    1115                 1120                 1125             


Gly Ile  Phe Gly Lys Gly Ser  Ala Tyr Ser Arg His  Asn Ala Glu 
    1130                 1135                 1140             


Arg Leu  Phe Lys Lys Leu Ile  Leu Asp Lys Ile Leu  Asp Glu Asp 
    1145                 1150                 1155             


Leu Tyr  Ile Asn Ala Asn Asp  Gln Ala Ile Ala Tyr  Val Met Leu 
    1160                 1165                 1170             


Gly Asn  Lys Ala Gln Thr Val  Leu Asn Gly Asn Leu  Lys Val Asp 
    1175                 1180                 1185             


Phe Met  Glu Thr Glu Asn Ser  Ser Ser Val Lys Lys  Gln Lys Ala 
    1190                 1195                 1200             


Leu Val  Ala Lys Val Ser Gln  Arg Glu Glu Met Val  Lys Lys Cys 
    1205                 1210                 1215             


Leu Gly  Glu Leu Thr Glu Val  Cys Lys Ser Leu Gly  Lys Val Phe 
    1220                 1225                 1230             


Gly Val  His Tyr Phe Asn Ile  Phe Asn Thr Val Thr  Leu Lys Lys 
    1235                 1240                 1245             


Leu Ala  Glu Ser Leu Ser Ser  Asp Pro Glu Val Leu  Leu Gln Ile 
    1250                 1255                 1260             


Asp Gly  Val Thr Glu Asp Lys  Leu Glu Lys Tyr Gly  Ala Glu Val 
    1265                 1270                 1275             


Ile Ser  Val Leu Gln Lys Tyr  Ser Glu Trp Thr Ser  Pro Ala Glu 
    1280                 1285                 1290             


Asp Ser  Ser Pro Gly Ile Ser  Leu Ser Ser Ser Arg  Gly Pro Gly 
    1295                 1300                 1305             


Arg Ser  Ala Ala Glu Glu Leu  Asp Glu Glu Ile Pro  Val Ser Ser 
    1310                 1315                 1320             


His Tyr  Phe Ala Ser Lys Thr  Arg Asn Glu Arg Lys  Arg Lys Lys 
    1325                 1330                 1335             


Met Pro  Ala Ser Gln Arg Ser  Lys Arg Arg Lys Thr  Ala Ser Ser 
    1340                 1345                 1350             


Gly Ser  Lys Ala Lys Gly Gly  Ser Ala Thr Cys Arg  Lys Ile Ser 
    1355                 1360                 1365             


Ser Lys  Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
    1370                 1375                 1380             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1385                 1390                 1395             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1400                 1405                 1410             


Tyr Ala  Phe Ser 
    1415         


<210> 56
<211> 846
<212> PRT
<213> Homo sapiens

<400> 56
Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro 
                805                 810                 815     


Val Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe 
            820                 825                 830         


Asn Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        835                 840                 845     


<210> 57
<211> 649
<212> PRT
<213> Homo sapiens

<400> 57
Met Ala Ser Val Ser Ala Leu Thr Glu Glu Leu Asp Ser Ile Thr Ser 
1               5                   10                  15      


Glu Leu His Ala Val Glu Ile Gln Ile Gln Glu Leu Thr Glu Arg Gln 
            20                  25                  30          


Gln Glu Leu Ile Gln Lys Lys Lys Val Leu Thr Lys Lys Ile Lys Gln 
        35                  40                  45              


Cys Leu Glu Asp Ser Asp Ala Gly Ala Ser Asn Glu Tyr Asp Ser Ser 
    50                  55                  60                  


Pro Ala Ala Trp Asn Lys Glu Asp Phe Pro Trp Ser Gly Lys Val Lys 
65                  70                  75                  80  


Asp Ile Leu Gln Asn Val Phe Lys Leu Glu Lys Phe Arg Pro Leu Gln 
                85                  90                  95      


Leu Glu Thr Ile Asn Val Thr Met Ala Gly Lys Glu Val Phe Leu Val 
            100                 105                 110         


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Leu 
        115                 120                 125             


Cys Ser Asp Gly Phe Thr Leu Val Ile Cys Pro Leu Ile Ser Leu Met 
    130                 135                 140                 


Glu Asp Gln Leu Met Val Leu Lys Gln Leu Gly Ile Ser Ala Thr Met 
145                 150                 155                 160 


Leu Asn Ala Ser Ser Ser Lys Glu His Val Lys Trp Val His Ala Glu 
                165                 170                 175     


Met Val Asn Lys Asn Ser Glu Leu Lys Leu Ile Tyr Val Thr Pro Glu 
            180                 185                 190         


Lys Ile Ala Lys Ser Lys Met Phe Met Ser Arg Leu Glu Lys Ala Tyr 
        195                 200                 205             


Glu Ala Arg Arg Phe Thr Arg Ile Ala Val Asp Glu Val His Cys Cys 
    210                 215                 220                 


Ser Gln Trp Gly His Asp Phe Arg Pro Asp Tyr Lys Ala Leu Gly Ile 
225                 230                 235                 240 


Leu Lys Arg Gln Phe Pro Asn Ala Ser Leu Ile Gly Leu Thr Ala Thr 
                245                 250                 255     


Ala Thr Asn His Val Leu Thr Asp Ala Gln Lys Ile Leu Cys Ile Glu 
            260                 265                 270         


Lys Cys Phe Thr Phe Thr Ala Ser Phe Asn Arg Pro Asn Leu Tyr Tyr 
        275                 280                 285             


Glu Val Arg Gln Lys Pro Ser Asn Thr Glu Asp Phe Ile Glu Asp Ile 
    290                 295                 300                 


Val Lys Leu Ile Asn Gly Arg Tyr Lys Gly Gln Ser Gly Ile Ile Tyr 
305                 310                 315                 320 


Cys Phe Ser Gln Lys Asp Ser Glu Gln Val Thr Val Ser Leu Gln Asn 
                325                 330                 335     


Leu Gly Ile His Ala Gly Ala Tyr His Ala Asn Leu Glu Pro Glu Asp 
            340                 345                 350         


Lys Thr Thr Val His Arg Lys Trp Ser Ala Asn Glu Ile Gln Val Val 
        355                 360                 365             


Val Ala Thr Val Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg 
    370                 375                 380                 


Phe Val Ile His His Ser Met Ser Lys Ser Met Glu Asn Tyr Tyr Gln 
385                 390                 395                 400 


Glu Ser Gly Arg Ala Gly Arg Asp Asp Met Lys Ala Asp Cys Ile Leu 
                405                 410                 415     


Tyr Tyr Gly Phe Gly Asp Ile Phe Arg Ile Ser Ser Met Val Val Met 
            420                 425                 430         


Glu Asn Val Gly Gln Gln Lys Leu Tyr Glu Met Val Ser Tyr Cys Gln 
        435                 440                 445             


Asn Ile Ser Lys Cys Arg Arg Val Leu Met Ala Gln His Phe Asp Glu 
    450                 455                 460                 


Val Trp Asn Ser Glu Ala Cys Asn Lys Met Cys Asp Asn Cys Cys Lys 
465                 470                 475                 480 


Asp Ser Ala Phe Glu Arg Lys Asn Ile Thr Glu Tyr Cys Arg Asp Leu 
                485                 490                 495     


Ile Lys Ile Leu Lys Gln Ala Glu Glu Leu Asn Glu Lys Leu Thr Pro 
            500                 505                 510         


Leu Lys Leu Ile Asp Ser Trp Met Gly Lys Gly Ala Ala Lys Leu Arg 
        515                 520                 525             


Val Ala Gly Val Val Ala Pro Thr Leu Pro Arg Glu Asp Leu Glu Lys 
    530                 535                 540                 


Ile Ile Ala His Phe Leu Ile Gln Gln Tyr Leu Lys Glu Asp Tyr Ser 
545                 550                 555                 560 


Phe Thr Ala Tyr Ala Thr Ile Ser Tyr Leu Lys Ile Gly Pro Lys Ala 
                565                 570                 575     


Asn Leu Leu Asn Asn Glu Ala His Ala Ile Thr Met Gln Val Thr Lys 
            580                 585                 590         


Ser Thr Gln Asn Ser Phe Arg Ala Glu Ser Ser Gln Thr Cys His Ser 
        595                 600                 605             


Glu Gln Gly Asp Lys Lys Met Glu Glu Lys Asn Ser Gly Asn Phe Gln 
    610                 615                 620                 


Lys Lys Ala Ala Asn Met Leu Gln Gln Ser Gly Ser Lys Asn Thr Gly 
625                 630                 635                 640 


Ala Lys Lys Arg Lys Ile Asp Asp Ala 
                645                 


<210> 58
<211> 760
<212> PRT
<213> Homo sapiens

<400> 58
Met Lys Leu Asn Val Asp Gly Leu Leu Val Tyr Phe Pro Tyr Asp Tyr 
1               5                   10                  15      


Ile Tyr Pro Glu Gln Phe Ser Tyr Met Arg Glu Leu Lys Arg Thr Leu 
            20                  25                  30          


Asp Ala Lys Gly His Gly Val Leu Glu Met Pro Ser Gly Thr Gly Lys 
        35                  40                  45              


Thr Val Ser Leu Leu Ala Leu Ile Met Ala Tyr Gln Arg Ala Tyr Pro 
    50                  55                  60                  


Leu Glu Val Thr Lys Leu Ile Tyr Cys Ser Arg Thr Val Pro Glu Ile 
65                  70                  75                  80  


Glu Lys Val Ile Glu Glu Leu Arg Lys Leu Leu Asn Phe Tyr Glu Lys 
                85                  90                  95      


Gln Glu Gly Glu Lys Leu Pro Phe Leu Gly Leu Ala Leu Ser Ser Arg 
            100                 105                 110         


Lys Asn Leu Cys Ile His Pro Glu Val Thr Pro Leu Arg Phe Gly Lys 
        115                 120                 125             


Asp Val Asp Gly Lys Cys His Ser Leu Thr Ala Ser Tyr Val Arg Ala 
    130                 135                 140                 


Gln Tyr Gln His Asp Thr Ser Leu Pro His Cys Arg Phe Tyr Glu Glu 
145                 150                 155                 160 


Phe Asp Ala His Gly Arg Glu Val Pro Leu Pro Ala Gly Ile Tyr Asn 
                165                 170                 175     


Leu Asp Asp Leu Lys Ala Leu Gly Arg Arg Gln Gly Trp Cys Pro Tyr 
            180                 185                 190         


Phe Leu Ala Arg Tyr Ser Ile Leu His Ala Asn Val Val Val Tyr Ser 
        195                 200                 205             


Tyr His Tyr Leu Leu Asp Pro Lys Ile Ala Asp Leu Val Ser Lys Glu 
    210                 215                 220                 


Leu Ala Arg Lys Ala Val Val Val Phe Asp Glu Ala His Asn Ile Asp 
225                 230                 235                 240 


Asn Val Cys Ile Asp Ser Met Ser Val Asn Leu Thr Arg Arg Thr Leu 
                245                 250                 255     


Asp Arg Cys Gln Gly Asn Leu Glu Thr Leu Gln Lys Thr Val Leu Arg 
            260                 265                 270         


Ile Lys Glu Thr Asp Glu Gln Arg Leu Arg Asp Glu Tyr Arg Arg Leu 
        275                 280                 285             


Val Glu Gly Leu Arg Glu Ala Ser Ala Ala Arg Glu Thr Asp Ala His 
    290                 295                 300                 


Leu Ala Asn Pro Val Leu Pro Asp Glu Val Leu Gln Glu Ala Val Pro 
305                 310                 315                 320 


Gly Ser Ile Arg Thr Ala Glu His Phe Leu Gly Phe Leu Arg Arg Leu 
                325                 330                 335     


Leu Glu Tyr Val Lys Trp Arg Leu Arg Val Gln His Val Val Gln Glu 
            340                 345                 350         


Ser Pro Pro Ala Phe Leu Ser Gly Leu Ala Gln Arg Val Cys Ile Gln 
        355                 360                 365             


Arg Lys Pro Leu Arg Phe Cys Ala Glu Arg Leu Arg Ser Leu Leu His 
    370                 375                 380                 


Thr Leu Glu Ile Thr Asp Leu Ala Asp Phe Ser Pro Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Asn Phe Ala Thr Leu Val Ser Thr Tyr Ala Lys Gly Phe Thr Ile 
                405                 410                 415     


Ile Ile Glu Pro Phe Asp Asp Arg Thr Pro Thr Ile Ala Asn Pro Ile 
            420                 425                 430         


Leu His Phe Ser Cys Met Asp Ala Ser Leu Ala Ile Lys Pro Val Phe 
        435                 440                 445             


Glu Arg Phe Gln Ser Val Ile Ile Thr Ser Gly Thr Leu Ser Pro Leu 
    450                 455                 460                 


Asp Ile Tyr Pro Lys Ile Leu Asp Phe His Pro Val Thr Met Ala Thr 
465                 470                 475                 480 


Phe Thr Met Thr Leu Ala Arg Val Cys Leu Cys Pro Met Ile Ile Gly 
                485                 490                 495     


Arg Gly Asn Asp Gln Val Ala Ile Ser Ser Lys Phe Glu Thr Arg Glu 
            500                 505                 510         


Asp Ile Ala Val Ile Arg Asn Tyr Gly Asn Leu Leu Leu Glu Met Ser 
        515                 520                 525             


Ala Val Val Pro Asp Gly Ile Val Ala Phe Phe Thr Ser Tyr Gln Tyr 
    530                 535                 540                 


Met Glu Ser Thr Val Ala Ser Trp Tyr Glu Gln Gly Ile Leu Glu Asn 
545                 550                 555                 560 


Ile Gln Arg Asn Lys Leu Leu Phe Ile Glu Thr Gln Asp Gly Ala Glu 
                565                 570                 575     


Thr Ser Val Ala Leu Glu Lys Tyr Gln Glu Ala Cys Glu Asn Gly Arg 
            580                 585                 590         


Gly Ala Ile Leu Leu Ser Val Ala Arg Gly Lys Val Ser Glu Gly Ile 
        595                 600                 605             


Asp Phe Val His His Tyr Gly Arg Ala Val Ile Met Phe Gly Val Pro 
    610                 615                 620                 


Tyr Val Tyr Thr Gln Ser Arg Ile Leu Lys Ala Arg Leu Glu Tyr Leu 
625                 630                 635                 640 


Arg Asp Gln Phe Gln Ile Arg Glu Asn Asp Phe Leu Thr Phe Asp Ala 
                645                 650                 655     


Met Arg His Ala Ala Gln Cys Val Gly Arg Ala Ile Arg Gly Lys Thr 
            660                 665                 670         


Asp Tyr Gly Leu Met Val Phe Ala Asp Lys Arg Phe Ala Arg Gly Asp 
        675                 680                 685             


Lys Arg Gly Lys Leu Pro Arg Trp Ile Gln Glu His Leu Thr Asp Ala 
    690                 695                 700                 


Asn Leu Asn Leu Thr Val Asp Glu Gly Val Gln Val Ala Lys Tyr Phe 
705                 710                 715                 720 


Leu Arg Gln Met Ala Gln Pro Phe His Arg Glu Asp Gln Leu Gly Leu 
                725                 730                 735     


Ser Leu Leu Ser Leu Glu Gln Leu Glu Ser Glu Glu Thr Leu Lys Arg 
            740                 745                 750         


Ile Glu Gln Ile Ala Gln Gln Leu 
        755                 760 


<210> 59
<211> 782
<212> PRT
<213> Homo sapiens

<400> 59
Met Gly Lys Arg Asp Arg Ala Asp Arg Asp Lys Lys Lys Ser Arg Lys 
1               5                   10                  15      


Arg His Tyr Glu Asp Glu Glu Asp Asp Glu Glu Asp Ala Pro Gly Asn 
            20                  25                  30          


Asp Pro Gln Glu Ala Val Pro Ser Ala Ala Gly Lys Gln Val Asp Glu 
        35                  40                  45              


Ser Gly Thr Lys Val Asp Glu Tyr Gly Ala Lys Asp Tyr Arg Leu Gln 
    50                  55                  60                  


Met Pro Leu Lys Asp Asp His Thr Ser Arg Pro Leu Trp Val Ala Pro 
65                  70                  75                  80  


Asp Gly His Ile Phe Leu Glu Ala Phe Ser Pro Val Tyr Lys Tyr Ala 
                85                  90                  95      


Gln Asp Phe Leu Val Ala Ile Ala Glu Pro Val Cys Arg Pro Thr His 
            100                 105                 110         


Val His Glu Tyr Lys Leu Thr Ala Tyr Ser Leu Tyr Ala Ala Val Ser 
        115                 120                 125             


Val Gly Leu Gln Thr Ser Asp Ile Thr Glu Tyr Leu Arg Lys Leu Ser 
    130                 135                 140                 


Lys Thr Gly Val Pro Asp Gly Ile Met Gln Phe Ile Lys Leu Cys Thr 
145                 150                 155                 160 


Val Ser Tyr Gly Lys Val Lys Leu Val Leu Lys His Asn Arg Tyr Phe 
                165                 170                 175     


Val Glu Ser Cys His Pro Asp Val Ile Gln His Leu Leu Gln Asp Pro 
            180                 185                 190         


Val Ile Arg Glu Cys Arg Leu Arg Asn Ser Glu Gly Glu Ala Thr Glu 
        195                 200                 205             


Leu Ile Thr Glu Thr Phe Thr Ser Lys Ser Ala Ile Ser Lys Thr Ala 
    210                 215                 220                 


Glu Ser Ser Gly Gly Pro Ser Thr Ser Arg Val Thr Asp Pro Gln Gly 
225                 230                 235                 240 


Lys Ser Asp Ile Pro Met Asp Leu Phe Asp Phe Tyr Glu Gln Met Asp 
                245                 250                 255     


Lys Asp Glu Glu Glu Glu Glu Glu Thr Gln Thr Val Ser Phe Glu Val 
            260                 265                 270         


Lys Gln Glu Met Ile Glu Glu Leu Gln Lys Arg Cys Ile His Leu Glu 
        275                 280                 285             


Tyr Pro Leu Leu Ala Glu Tyr Asp Phe Arg Asn Asp Ser Val Asn Pro 
    290                 295                 300                 


Asp Ile Asn Ile Asp Leu Lys Pro Thr Ala Val Leu Arg Pro Tyr Gln 
305                 310                 315                 320 


Glu Lys Ser Leu Arg Lys Met Phe Gly Asn Gly Arg Ala Arg Ser Gly 
                325                 330                 335     


Val Ile Val Leu Pro Cys Gly Ala Gly Lys Ser Leu Val Gly Val Thr 
            340                 345                 350         


Ala Ala Cys Thr Val Arg Lys Arg Cys Leu Val Leu Gly Asn Ser Ala 
        355                 360                 365             


Val Ser Val Glu Gln Trp Lys Ala Gln Phe Lys Met Trp Ser Thr Ile 
    370                 375                 380                 


Asp Asp Ser Gln Ile Cys Arg Phe Thr Ser Asp Ala Lys Asp Lys Pro 
385                 390                 395                 400 


Ile Gly Cys Ser Val Ala Ile Ser Thr Tyr Ser Met Leu Gly His Thr 
                405                 410                 415     


Thr Lys Arg Ser Trp Glu Ala Glu Arg Val Met Glu Trp Leu Lys Thr 
            420                 425                 430         


Gln Glu Trp Gly Leu Met Ile Leu Asp Glu Val His Thr Ile Pro Ala 
        435                 440                 445             


Lys Met Phe Arg Arg Val Leu Thr Ile Val Gln Ala His Cys Lys Leu 
    450                 455                 460                 


Gly Leu Thr Ala Thr Leu Val Arg Glu Asp Asp Lys Ile Val Asp Leu 
465                 470                 475                 480 


Asn Phe Leu Ile Gly Pro Lys Leu Tyr Glu Ala Asn Trp Met Glu Leu 
                485                 490                 495     


Gln Asn Asn Gly Tyr Ile Ala Lys Val Gln Cys Ala Glu Val Trp Cys 
            500                 505                 510         


Pro Met Ser Pro Glu Phe Tyr Arg Glu Tyr Val Ala Ile Lys Thr Lys 
        515                 520                 525             


Lys Arg Ile Leu Leu Tyr Thr Met Asn Pro Asn Lys Phe Arg Ala Cys 
    530                 535                 540                 


Gln Phe Leu Ile Lys Phe His Glu Arg Arg Asn Asp Lys Ile Ile Val 
545                 550                 555                 560 


Phe Ala Asp Asn Val Phe Ala Leu Lys Glu Tyr Ala Ile Arg Leu Asn 
                565                 570                 575     


Lys Pro Tyr Ile Tyr Gly Pro Thr Ser Gln Gly Glu Arg Met Gln Ile 
            580                 585                 590         


Leu Gln Asn Phe Lys His Asn Pro Lys Ile Asn Thr Ile Phe Ile Ser 
        595                 600                 605             


Lys Val Gly Asp Thr Ser Phe Asp Leu Pro Glu Ala Asn Val Leu Ile 
    610                 615                 620                 


Gln Ile Ser Ser His Gly Gly Ser Arg Arg Gln Glu Ala Gln Arg Leu 
625                 630                 635                 640 


Gly Arg Val Leu Arg Ala Lys Lys Gly Met Val Ala Glu Glu Tyr Asn 
                645                 650                 655     


Ala Phe Phe Tyr Ser Leu Val Ser Gln Asp Thr Gln Glu Met Ala Tyr 
            660                 665                 670         


Ser Thr Lys Arg Gln Arg Phe Leu Val Asp Gln Gly Tyr Ser Phe Lys 
        675                 680                 685             


Val Ile Thr Lys Leu Ala Gly Met Glu Glu Glu Asp Leu Ala Phe Ser 
    690                 695                 700                 


Thr Lys Glu Glu Gln Gln Gln Leu Leu Gln Lys Val Leu Ala Ala Thr 
705                 710                 715                 720 


Asp Leu Asp Ala Glu Glu Glu Val Val Ala Gly Glu Phe Gly Ser Arg 
                725                 730                 735     


Ser Ser Gln Ala Ser Arg Arg Phe Gly Thr Met Ser Ser Met Ser Gly 
            740                 745                 750         


Ala Asp Asp Thr Val Tyr Met Glu Tyr His Ser Ser Arg Ser Lys Ala 
        755                 760                 765             


Pro Ser Lys His Val His Pro Leu Phe Lys Arg Phe Arg Lys 
    770                 775                 780         


<210> 60
<211> 1432
<212> PRT
<213> Homo sapiens

<400> 60
Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gln Gln Arg Lys Cys Pro 
1               5                   10                  15      


Glu Trp Met Asn Val Gln Asn Lys Arg Cys Ala Val Glu Glu Arg Lys 
            20                  25                  30          


Ala Cys Val Arg Lys Ser Val Phe Glu Asp Asp Leu Pro Phe Leu Glu 
        35                  40                  45              


Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Ala Ser Asp Cys Ser Phe 
    50                  55                  60                  


Leu Ser Glu Asp Ile Ser Met Ser Leu Ser Asp Gly Asp Val Val Gly 
65                  70                  75                  80  


Phe Asp Met Glu Trp Pro Pro Leu Tyr Asn Arg Gly Lys Leu Gly Lys 
                85                  90                  95      


Val Ala Leu Ile Gln Leu Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe 
            100                 105                 110         


His Val Ser Ser Met Ser Val Phe Pro Gln Gly Leu Lys Met Leu Leu 
        115                 120                 125             


Glu Asn Lys Ala Val Lys Lys Ala Gly Val Gly Ile Glu Gly Asp Gln 
    130                 135                 140                 


Trp Lys Leu Leu Arg Asp Phe Asp Ile Lys Leu Lys Asn Phe Val Glu 
145                 150                 155                 160 


Leu Thr Asp Val Ala Asn Lys Lys Leu Lys Cys Thr Glu Thr Trp Ser 
                165                 170                 175     


Leu Asn Ser Leu Val Lys His Leu Leu Gly Lys Gln Leu Leu Lys Asp 
            180                 185                 190         


Lys Ser Ile Arg Cys Ser Asn Trp Ser Lys Phe Pro Leu Thr Glu Asp 
        195                 200                 205             


Gln Lys Leu Tyr Ala Ala Thr Asp Ala Tyr Ala Gly Phe Ile Ile Tyr 
    210                 215                 220                 


Arg Asn Leu Glu Ile Leu Asp Asp Thr Val Gln Arg Phe Ala Ile Asn 
225                 230                 235                 240 


Lys Glu Glu Glu Ile Leu Leu Ser Asp Met Asn Lys Gln Leu Thr Ser 
                245                 250                 255     


Ile Ser Glu Glu Val Met Asp Leu Ala Lys His Leu Pro His Ala Phe 
            260                 265                 270         


Ser Lys Leu Glu Asn Pro Arg Arg Val Ser Ile Leu Leu Lys Asp Ile 
        275                 280                 285             


Ser Glu Asn Leu Tyr Ser Leu Arg Arg Met Ile Ile Gly Ser Thr Asn 
    290                 295                 300                 


Ile Glu Thr Glu Leu Arg Pro Ser Asn Asn Leu Asn Leu Leu Ser Phe 
305                 310                 315                 320 


Glu Asp Ser Thr Thr Gly Gly Val Gln Gln Lys Gln Ile Arg Glu His 
                325                 330                 335     


Glu Val Leu Ile His Val Glu Asp Glu Thr Trp Asp Pro Thr Leu Asp 
            340                 345                 350         


His Leu Ala Lys His Asp Gly Glu Asp Val Leu Gly Asn Lys Val Glu 
        355                 360                 365             


Arg Lys Glu Asp Gly Phe Glu Asp Gly Val Glu Asp Asn Lys Leu Lys 
    370                 375                 380                 


Glu Asn Met Glu Arg Ala Cys Leu Met Ser Leu Asp Ile Thr Glu His 
385                 390                 395                 400 


Glu Leu Gln Ile Leu Glu Gln Gln Ser Gln Glu Glu Tyr Leu Ser Asp 
                405                 410                 415     


Ile Ala Tyr Lys Ser Thr Glu His Leu Ser Pro Asn Asp Asn Glu Asn 
            420                 425                 430         


Asp Thr Ser Tyr Val Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met 
        435                 440                 445             


Leu Lys His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val 
    450                 455                 460                 


Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys Ser Leu Glu 
465                 470                 475                 480 


Asn Leu Asn Ser Gly Thr Val Glu Pro Thr His Ser Lys Cys Leu Lys 
                485                 490                 495     


Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Glu Glu Asp Asp 
            500                 505                 510         


Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Lys Asp Phe Leu 
        515                 520                 525             


Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Lys Met Tyr Phe 
    530                 535                 540                 


Gly His Ser Ser Phe Lys Pro Val Gln Trp Lys Val Ile His Ser Val 
545                 550                 555                 560 


Leu Glu Glu Arg Arg Asp Asn Val Ala Val Met Ala Thr Gly Tyr Gly 
                565                 570                 575     


Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gly Lys Ile Gly 
            580                 585                 590         


Leu Val Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gln Val Leu Gln 
        595                 600                 605             


Leu Lys Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Ser Ala Gln Ser 
    610                 615                 620                 


Glu Asn Val Leu Thr Asp Ile Lys Leu Gly Lys Tyr Arg Ile Val Tyr 
625                 630                 635                 640 


Val Thr Pro Glu Tyr Cys Ser Gly Asn Met Gly Leu Leu Gln Gln Leu 
                645                 650                 655     


Glu Ala Asp Ile Gly Ile Thr Leu Ile Ala Val Asp Glu Ala His Cys 
            660                 665                 670         


Ile Ser Glu Trp Gly His Asp Phe Arg Asp Ser Phe Arg Lys Leu Gly 
        675                 680                 685             


Ser Leu Lys Thr Ala Leu Pro Met Val Pro Ile Val Ala Leu Thr Ala 
    690                 695                 700                 


Thr Ala Ser Ser Ser Ile Arg Glu Asp Ile Val Arg Cys Leu Asn Leu 
705                 710                 715                 720 


Arg Asn Pro Gln Ile Thr Cys Thr Gly Phe Asp Arg Pro Asn Leu Tyr 
                725                 730                 735     


Leu Glu Val Arg Arg Lys Thr Gly Asn Ile Leu Gln Asp Leu Gln Pro 
            740                 745                 750         


Phe Leu Val Lys Thr Ser Ser His Trp Glu Phe Glu Gly Pro Thr Ile 
        755                 760                 765             


Ile Tyr Cys Pro Ser Arg Lys Met Thr Gln Gln Val Thr Gly Glu Leu 
    770                 775                 780                 


Arg Lys Leu Asn Leu Ser Cys Gly Thr Tyr His Ala Gly Met Ser Phe 
785                 790                 795                 800 


Ser Thr Arg Lys Asp Ile His His Arg Phe Val Arg Asp Glu Ile Gln 
                805                 810                 815     


Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gly Ile Asn Lys Ala Asp 
            820                 825                 830         


Ile Arg Gln Val Ile His Tyr Gly Ala Pro Lys Asp Met Glu Ser Tyr 
        835                 840                 845             


Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Ser Ser Cys 
    850                 855                 860                 


His Val Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn Arg His Leu Leu 
865                 870                 875                 880 


Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Leu Lys Met Met 
                885                 890                 895     


Ala Lys Met Glu Lys Tyr Leu His Ser Ser Arg Cys Arg Arg Gln Ile 
            900                 905                 910         


Ile Leu Ser His Phe Glu Asp Lys Gln Val Gln Lys Ala Ser Leu Gly 
        915                 920                 925             


Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Ser Arg Leu Asp 
    930                 935                 940                 


His Cys Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Trp Asp Phe Gly 
945                 950                 955                 960 


Pro Gln Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Leu Gly Glu Lys 
                965                 970                 975     


Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Ser Asn Ser Gln 
            980                 985                 990         


Arg Leu Ala Asp Gln Tyr Arg Arg  His Ser Leu Phe Gly  Thr Gly Lys 
        995                 1000                 1005             


Asp Gln  Thr Glu Ser Trp Trp  Lys Ala Phe Ser Arg  Gln Leu Ile 
    1010                 1015                 1020             


Thr Glu  Gly Phe Leu Val Glu  Val Ser Arg Tyr Asn  Lys Phe Met 
    1025                 1030                 1035             


Lys Ile  Cys Ala Leu Thr Lys  Lys Gly Arg Asn Trp  Leu His Lys 
    1040                 1045                 1050             


Ala Asn  Thr Glu Ser Gln Ser  Leu Ile Leu Gln Ala  Asn Glu Glu 
    1055                 1060                 1065             


Leu Cys  Pro Lys Lys Leu Leu  Leu Pro Ser Ser Lys  Thr Val Ser 
    1070                 1075                 1080             


Ser Gly  Thr Lys Glu His Cys  Tyr Asn Gln Val Pro  Val Glu Leu 
    1085                 1090                 1095             


Ser Thr  Glu Lys Lys Ser Asn  Leu Glu Lys Leu Tyr  Ser Tyr Lys 
    1100                 1105                 1110             


Pro Cys  Asp Lys Ile Ser Ser  Gly Ser Asn Ile Ser  Lys Lys Ser 
    1115                 1120                 1125             


Ile Met  Val Gln Ser Pro Glu  Lys Ala Tyr Ser Ser  Ser Gln Pro 
    1130                 1135                 1140             


Val Ile  Ser Ala Gln Glu Gln  Glu Thr Gln Ile Val  Leu Tyr Gly 
    1145                 1150                 1155             


Lys Leu  Val Glu Ala Arg Gln  Lys His Ala Asn Lys  Met Asp Val 
    1160                 1165                 1170             


Pro Pro  Ala Ile Leu Ala Thr  Asn Lys Ile Leu Val  Asp Met Ala 
    1175                 1180                 1185             


Lys Met  Arg Pro Thr Thr Val  Glu Asn Val Lys Arg  Ile Asp Gly 
    1190                 1195                 1200             


Val Ser  Glu Gly Lys Ala Ala  Met Leu Ala Pro Leu  Leu Glu Val 
    1205                 1210                 1215             


Ile Lys  His Phe Cys Gln Thr  Asn Ser Val Gln Thr  Asp Leu Phe 
    1220                 1225                 1230             


Ser Ser  Thr Lys Pro Gln Glu  Glu Gln Lys Thr Ser  Leu Val Ala 
    1235                 1240                 1245             


Lys Asn  Lys Ile Cys Thr Leu  Ser Gln Ser Met Ala  Ile Thr Tyr 
    1250                 1255                 1260             


Ser Leu  Phe Gln Glu Lys Lys  Met Pro Leu Lys Ser  Ile Ala Glu 
    1265                 1270                 1275             


Ser Arg  Ile Leu Pro Leu Met  Thr Ile Gly Met His  Leu Ser Gln 
    1280                 1285                 1290             


Ala Val  Lys Ala Gly Cys Pro  Leu Asp Leu Glu Arg  Ala Gly Leu 
    1295                 1300                 1305             


Thr Pro  Glu Val Gln Lys Ile  Ile Ala Asp Val Ile  Arg Asn Pro 
    1310                 1315                 1320             


Pro Val  Asn Ser Asp Met Ser  Lys Ile Ser Leu Ile  Arg Met Leu 
    1325                 1330                 1335             


Val Pro  Glu Asn Ile Asp Thr  Tyr Leu Ile His Met  Ala Ile Glu 
    1340                 1345                 1350             


Ile Leu  Lys His Gly Pro Asp  Ser Gly Leu Gln Pro  Ser Cys Asp 
    1355                 1360                 1365             


Val Asn  Lys Arg Arg Cys Phe  Pro Gly Ser Glu Glu  Ile Cys Ser 
    1370                 1375                 1380             


Ser Ser  Lys Arg Ser Lys Glu  Glu Val Gly Ile Asn  Thr Glu Thr 
    1385                 1390                 1395             


Ser Ser  Ala Glu Arg Lys Arg  Arg Leu Pro Val Trp  Phe Ala Lys 
    1400                 1405                 1410             


Gly Ser  Asp Thr Ser Lys Lys  Leu Met Asp Lys Thr  Lys Arg Gly 
    1415                 1420                 1425             


Gly Leu  Phe Ser 
    1430         


<210> 61
<211> 991
<212> PRT
<213> Homo sapiens

<400> 61
Met Ser Ser His His Thr Thr Phe Pro Phe Asp Pro Glu Arg Arg Val 
1               5                   10                  15      


Arg Ser Thr Leu Lys Lys Val Phe Gly Phe Asp Ser Phe Lys Thr Pro 
            20                  25                  30          


Leu Gln Glu Ser Ala Thr Met Ala Val Val Lys Gly Asn Lys Asp Val 
        35                  40                  45              


Phe Val Cys Met Pro Thr Gly Ala Gly Lys Ser Leu Cys Tyr Gln Leu 
    50                  55                  60                  


Pro Ala Leu Leu Ala Lys Gly Ile Thr Ile Val Val Ser Pro Leu Ile 
65                  70                  75                  80  


Ala Leu Ile Gln Asp Gln Val Asp His Leu Leu Thr Leu Lys Val Arg 
                85                  90                  95      


Val Ser Ser Leu Asn Ser Lys Leu Ser Ala Gln Glu Arg Lys Glu Leu 
            100                 105                 110         


Leu Ala Asp Leu Glu Arg Glu Lys Pro Gln Thr Lys Ile Leu Tyr Ile 
        115                 120                 125             


Thr Pro Glu Met Ala Ala Ser Ser Ser Phe Gln Pro Thr Leu Asn Ser 
    130                 135                 140                 


Leu Val Ser Arg His Leu Leu Ser Tyr Leu Val Val Asp Glu Ala His 
145                 150                 155                 160 


Cys Val Ser Gln Trp Gly His Asp Phe Arg Pro Asp Tyr Leu Arg Leu 
                165                 170                 175     


Gly Ala Leu Arg Ser Arg Leu Gly His Ala Pro Cys Val Ala Leu Thr 
            180                 185                 190         


Ala Thr Ala Thr Pro Gln Val Gln Glu Asp Val Phe Ala Ala Leu His 
        195                 200                 205             


Leu Lys Lys Pro Val Ala Ile Phe Lys Thr Pro Cys Phe Arg Ala Asn 
    210                 215                 220                 


Leu Phe Tyr Asp Val Gln Phe Lys Glu Leu Ile Ser Asp Pro Tyr Gly 
225                 230                 235                 240 


Asn Leu Lys Asp Phe Cys Leu Lys Ala Leu Gly Gln Glu Ala Asp Lys 
                245                 250                 255     


Gly Leu Ser Gly Cys Gly Ile Val Tyr Cys Arg Thr Arg Glu Ala Cys 
            260                 265                 270         


Glu Gln Leu Ala Ile Glu Leu Ser Cys Arg Gly Val Asn Ala Lys Ala 
        275                 280                 285             


Tyr His Ala Gly Leu Lys Ala Ser Glu Arg Thr Leu Val Gln Asn Asp 
    290                 295                 300                 


Trp Met Glu Glu Lys Val Pro Val Ile Val Ala Thr Ile Ser Phe Gly 
305                 310                 315                 320 


Met Gly Val Asp Lys Ala Asn Val Arg Phe Val Ala His Trp Asn Ile 
                325                 330                 335     


Ala Lys Ser Met Ala Gly Tyr Tyr Gln Glu Ser Gly Arg Ala Gly Arg 
            340                 345                 350         


Asp Gly Lys Pro Ser Trp Cys Arg Leu Tyr Tyr Ser Arg Asn Asp Arg 
        355                 360                 365             


Asp Gln Val Ser Phe Leu Ile Arg Lys Glu Val Ala Lys Leu Gln Glu 
    370                 375                 380                 


Lys Arg Gly Asn Lys Ala Ser Asp Lys Ala Thr Ile Met Ala Phe Asp 
385                 390                 395                 400 


Ala Leu Val Thr Phe Cys Glu Glu Leu Gly Cys Arg His Ala Ala Ile 
                405                 410                 415     


Ala Lys Tyr Phe Gly Asp Ala Leu Pro Ala Cys Ala Lys Gly Cys Asp 
            420                 425                 430         


His Cys Gln Asn Pro Thr Ala Val Arg Arg Arg Leu Glu Ala Leu Glu 
        435                 440                 445             


Arg Ser Ser Ser Trp Ser Lys Thr Cys Ile Gly Pro Ser Gln Gly Asn 
    450                 455                 460                 


Gly Phe Asp Pro Glu Leu Tyr Glu Gly Gly Arg Lys Gly Tyr Gly Asp 
465                 470                 475                 480 


Phe Ser Arg Tyr Asp Glu Gly Ser Gly Gly Ser Gly Asp Glu Gly Arg 
                485                 490                 495     


Asp Glu Ala His Lys Arg Glu Trp Asn Leu Phe Tyr Gln Lys Gln Met 
            500                 505                 510         


Gln Leu Arg Lys Gly Lys Asp Pro Lys Ile Glu Glu Phe Val Pro Pro 
        515                 520                 525             


Asp Glu Asn Cys Pro Leu Lys Glu Ala Ser Ser Arg Arg Ile Pro Arg 
    530                 535                 540                 


Leu Thr Val Lys Ala Arg Glu His Cys Leu Arg Leu Leu Glu Glu Ala 
545                 550                 555                 560 


Leu Ser Ser Asn Arg Gln Ser Thr Arg Thr Ala Asp Glu Ala Asp Leu 
                565                 570                 575     


Arg Ala Lys Ala Val Glu Leu Glu His Glu Thr Phe Arg Asn Ala Lys 
            580                 585                 590         


Val Ala Asn Leu Tyr Lys Ala Ser Val Leu Lys Lys Val Ala Asp Ile 
        595                 600                 605             


His Arg Ala Ser Lys Asp Gly Gln Pro Tyr Asp Met Gly Gly Ser Ala 
    610                 615                 620                 


Lys Ser Cys Ser Ala Gln Ala Glu Pro Pro Glu Pro Asn Glu Tyr Asp 
625                 630                 635                 640 


Ile Pro Pro Ala Ser His Val Tyr Ser Leu Lys Pro Lys Arg Val Gly 
                645                 650                 655     


Ala Gly Phe Pro Lys Gly Ser Cys Pro Phe Gln Thr Ala Thr Glu Leu 
            660                 665                 670         


Met Glu Thr Thr Arg Ile Arg Glu Gln Ala Pro Gln Pro Glu Arg Gly 
        675                 680                 685             


Gly Glu His Glu Pro Pro Ser Arg Pro Cys Gly Leu Leu Asp Glu Asp 
    690                 695                 700                 


Gly Ser Glu Pro Leu Pro Gly Pro Arg Gly Glu Val Pro Gly Gly Ser 
705                 710                 715                 720 


Ala His Tyr Gly Gly Pro Ser Pro Glu Lys Lys Ala Lys Ser Ser Ser 
                725                 730                 735     


Gly Gly Ser Ser Leu Ala Lys Gly Arg Ala Ser Lys Lys Gln Gln Leu 
            740                 745                 750         


Leu Ala Thr Ala Ala His Lys Asp Ser Gln Ser Ile Ala Arg Phe Phe 
        755                 760                 765             


Cys Arg Arg Val Glu Ser Pro Ala Leu Leu Ala Ser Ala Pro Glu Ala 
    770                 775                 780                 


Glu Gly Ala Cys Pro Ser Cys Glu Gly Val Gln Gly Pro Pro Met Ala 
785                 790                 795                 800 


Pro Glu Lys Tyr Thr Gly Glu Glu Asp Gly Ala Gly Gly His Ser Pro 
                805                 810                 815     


Ala Pro Pro Gln Thr Glu Glu Cys Leu Arg Glu Arg Pro Ser Thr Cys 
            820                 825                 830         


Pro Pro Arg Asp Gln Gly Thr Pro Glu Val Gln Pro Thr Pro Ala Lys 
        835                 840                 845             


Asp Thr Trp Lys Gly Lys Arg Pro Arg Ser Gln Gln Glu Asn Pro Glu 
    850                 855                 860                 


Ser Gln Pro Gln Lys Arg Pro Arg Pro Ser Ala Lys Pro Ser Val Val 
865                 870                 875                 880 


Ala Glu Val Lys Gly Ser Val Ser Ala Ser Glu Gln Gly Thr Leu Asn 
                885                 890                 895     


Pro Thr Ala Gln Asp Pro Phe Gln Leu Ser Ala Pro Gly Val Ser Leu 
            900                 905                 910         


Lys Glu Ala Ala Asn Val Val Val Lys Cys Leu Thr Pro Phe Tyr Lys 
        915                 920                 925             


Glu Gly Lys Phe Ala Ser Lys Glu Leu Phe Lys Gly Phe Ala Arg His 
    930                 935                 940                 


Leu Ser His Leu Leu Thr Gln Lys Thr Ser Pro Gly Arg Ser Val Lys 
945                 950                 955                 960 


Glu Glu Ala Gln Asn Leu Ile Arg His Phe Phe His Gly Arg Ala Arg 
                965                 970                 975     


Cys Glu Ser Glu Ala Asp Trp His Gly Leu Cys Gly Pro Gln Arg 
            980                 985                 990     


<210> 62
<211> 1208
<212> PRT
<213> Homo sapiens

<400> 62
Met Glu Arg Leu Arg Asp Val Arg Glu Arg Leu Gln Ala Trp Glu Arg 
1               5                   10                  15      


Ala Phe Arg Arg Gln Arg Gly Arg Arg Pro Ser Gln Asp Asp Val Glu 
            20                  25                  30          


Ala Ala Pro Glu Glu Thr Arg Ala Leu Tyr Arg Glu Tyr Arg Thr Leu 
        35                  40                  45              


Lys Arg Thr Thr Gly Gln Ala Gly Gly Gly Leu Arg Ser Ser Glu Ser 
    50                  55                  60                  


Leu Pro Ala Ala Ala Glu Glu Ala Pro Glu Pro Arg Cys Trp Gly Pro 
65                  70                  75                  80  


His Leu Asn Arg Ala Ala Thr Lys Ser Pro Gln Ser Thr Pro Gly Arg 
                85                  90                  95      


Ser Arg Gln Gly Ser Val Pro Asp Tyr Gly Gln Arg Leu Lys Ala Asn 
            100                 105                 110         


Leu Lys Gly Thr Leu Gln Ala Gly Pro Ala Leu Gly Arg Arg Pro Trp 
        115                 120                 125             


Pro Leu Gly Arg Ala Ser Ser Lys Ala Ser Thr Pro Lys Pro Pro Gly 
    130                 135                 140                 


Thr Gly Pro Val Pro Ser Phe Ala Glu Lys Val Ser Asp Glu Pro Pro 
145                 150                 155                 160 


Gln Leu Pro Glu Pro Gln Pro Arg Pro Gly Arg Leu Gln His Leu Gln 
                165                 170                 175     


Ala Ser Leu Ser Gln Arg Leu Gly Ser Leu Asp Pro Gly Trp Leu Gln 
            180                 185                 190         


Arg Cys His Ser Glu Val Pro Asp Phe Leu Gly Ala Pro Lys Ala Cys 
        195                 200                 205             


Arg Pro Asp Leu Gly Ser Glu Glu Ser Gln Leu Leu Ile Pro Gly Glu 
    210                 215                 220                 


Ser Ala Val Leu Gly Pro Gly Ala Gly Ser Gln Gly Pro Glu Ala Ser 
225                 230                 235                 240 


Ala Phe Gln Glu Val Ser Ile Arg Val Gly Ser Pro Gln Pro Ser Ser 
                245                 250                 255     


Ser Gly Gly Glu Lys Arg Arg Trp Asn Glu Glu Pro Trp Glu Ser Pro 
            260                 265                 270         


Ala Gln Val Gln Gln Glu Ser Ser Gln Ala Gly Pro Pro Ser Glu Gly 
        275                 280                 285             


Ala Gly Ala Val Ala Val Glu Glu Asp Pro Pro Gly Glu Pro Val Gln 
    290                 295                 300                 


Ala Gln Pro Pro Gln Pro Cys Ser Ser Pro Ser Asn Pro Arg Tyr His 
305                 310                 315                 320 


Gly Leu Ser Pro Ser Ser Gln Ala Arg Ala Gly Lys Ala Glu Gly Thr 
                325                 330                 335     


Ala Pro Leu His Ile Phe Pro Arg Leu Ala Arg His Asp Arg Gly Asn 
            340                 345                 350         


Tyr Val Arg Leu Asn Met Lys Gln Lys His Tyr Val Arg Gly Arg Ala 
        355                 360                 365             


Leu Arg Ser Arg Leu Leu Arg Lys Gln Ala Trp Lys Gln Lys Trp Arg 
    370                 375                 380                 


Lys Lys Gly Glu Cys Phe Gly Gly Gly Gly Ala Thr Val Thr Thr Lys 
385                 390                 395                 400 


Glu Ser Cys Phe Leu Asn Glu Gln Phe Asp His Trp Ala Ala Gln Cys 
                405                 410                 415     


Pro Arg Pro Ala Ser Glu Glu Asp Thr Asp Ala Val Gly Pro Glu Pro 
            420                 425                 430         


Leu Val Pro Ser Pro Gln Pro Val Pro Glu Val Pro Ser Leu Asp Pro 
        435                 440                 445             


Thr Val Leu Pro Leu Tyr Ser Leu Gly Pro Ser Gly Gln Leu Ala Glu 
    450                 455                 460                 


Thr Pro Ala Glu Val Phe Gln Ala Leu Glu Gln Leu Gly His Gln Ala 
465                 470                 475                 480 


Phe Arg Pro Gly Gln Glu Arg Ala Val Met Arg Ile Leu Ser Gly Ile 
                485                 490                 495     


Ser Thr Leu Leu Val Leu Pro Thr Gly Ala Gly Lys Ser Leu Cys Tyr 
            500                 505                 510         


Gln Leu Pro Ala Leu Leu Tyr Ser Arg Arg Ser Pro Cys Leu Thr Leu 
        515                 520                 525             


Val Val Ser Pro Leu Leu Ser Leu Met Asp Asp Gln Val Ser Gly Leu 
    530                 535                 540                 


Pro Pro Cys Leu Lys Ala Ala Cys Ile His Ser Gly Met Thr Arg Lys 
545                 550                 555                 560 


Gln Arg Glu Ser Val Leu Gln Lys Ile Arg Ala Ala Gln Val His Val 
                565                 570                 575     


Leu Met Leu Thr Pro Glu Ala Leu Val Gly Ala Gly Gly Leu Pro Pro 
            580                 585                 590         


Ala Ala Gln Leu Pro Pro Val Ala Phe Ala Cys Ile Asp Glu Ala His 
        595                 600                 605             


Cys Leu Ser Gln Trp Ser His Asn Phe Arg Pro Cys Tyr Leu Arg Val 
    610                 615                 620                 


Cys Lys Val Leu Arg Glu Arg Met Gly Val His Cys Phe Leu Gly Leu 
625                 630                 635                 640 


Thr Ala Thr Ala Thr Arg Arg Thr Ala Ser Asp Val Ala Gln His Leu 
                645                 650                 655     


Ala Val Ala Glu Glu Pro Asp Leu His Gly Pro Ala Pro Val Pro Thr 
            660                 665                 670         


Asn Leu His Leu Ser Val Ser Met Asp Arg Asp Thr Asp Gln Ala Leu 
        675                 680                 685             


Leu Thr Leu Leu Gln Gly Lys Arg Phe Gln Asn Leu Asp Ser Ile Ile 
    690                 695                 700                 


Ile Tyr Cys Asn Arg Arg Glu Asp Thr Glu Arg Ile Ala Ala Leu Leu 
705                 710                 715                 720 


Arg Thr Cys Leu His Ala Ala Trp Val Pro Gly Ser Gly Gly Arg Ala 
                725                 730                 735     


Pro Lys Thr Thr Ala Glu Ala Tyr His Ala Gly Met Cys Ser Arg Glu 
            740                 745                 750         


Arg Arg Arg Val Gln Arg Ala Phe Met Gln Gly Gln Leu Arg Val Val 
        755                 760                 765             


Val Ala Thr Val Ala Phe Gly Met Gly Leu Asp Arg Pro Asp Val Arg 
    770                 775                 780                 


Ala Val Leu His Leu Gly Leu Pro Pro Ser Phe Glu Ser Tyr Val Gln 
785                 790                 795                 800 


Ala Val Gly Arg Ala Gly Arg Asp Gly Gln Pro Ala His Cys His Leu 
                805                 810                 815     


Phe Leu Gln Pro Gln Gly Glu Asp Leu Arg Glu Leu Arg Arg His Val 
            820                 825                 830         


His Ala Asp Ser Thr Asp Phe Leu Ala Val Lys Arg Leu Val Gln Arg 
        835                 840                 845             


Val Phe Pro Ala Cys Thr Cys Thr Cys Thr Arg Pro Pro Ser Glu Gln 
    850                 855                 860                 


Glu Gly Ala Val Gly Gly Glu Arg Pro Val Pro Lys Tyr Pro Pro Gln 
865                 870                 875                 880 


Glu Ala Glu Gln Leu Ser His Gln Ala Ala Pro Gly Pro Arg Arg Val 
                885                 890                 895     


Cys Met Gly His Glu Arg Ala Leu Pro Ile Gln Leu Thr Val Gln Ala 
            900                 905                 910         


Leu Asp Met Pro Glu Glu Ala Ile Glu Thr Leu Leu Cys Tyr Leu Glu 
        915                 920                 925             


Leu His Pro His His Trp Leu Glu Leu Leu Ala Thr Thr Tyr Thr His 
    930                 935                 940                 


Cys Arg Leu Asn Cys Pro Gly Gly Pro Ala Gln Leu Gln Ala Leu Ala 
945                 950                 955                 960 


His Arg Cys Pro Pro Leu Ala Val Cys Leu Ala Gln Gln Leu Pro Glu 
                965                 970                 975     


Asp Pro Gly Gln Gly Ser Ser Ser Val Glu Phe Asp Met Val Lys Leu 
            980                 985                 990         


Val Asp Ser Met Gly Trp Glu Leu  Ala Ser Val Arg Arg  Ala Leu Cys 
        995                 1000                 1005             


Gln Leu  Gln Trp Asp His Glu  Pro Arg Thr Gly Val  Arg Arg Gly 
    1010                 1015                 1020             


Thr Gly  Val Leu Val Glu Phe  Ser Glu Leu Ala Phe  His Leu Arg 
    1025                 1030                 1035             


Ser Pro  Gly Asp Leu Thr Ala  Glu Glu Lys Asp Gln  Ile Cys Asp 
    1040                 1045                 1050             


Phe Leu  Tyr Gly Arg Val Gln  Ala Arg Glu Arg Gln  Ala Leu Ala 
    1055                 1060                 1065             


Arg Leu  Arg Arg Thr Phe Gln  Ala Phe His Ser Val  Ala Phe Pro 
    1070                 1075                 1080             


Ser Cys  Gly Pro Cys Leu Glu  Gln Gln Asp Glu Glu  Arg Ser Thr 
    1085                 1090                 1095             


Arg Leu  Lys Asp Leu Leu Gly  Arg Tyr Phe Glu Glu  Glu Glu Gly 
    1100                 1105                 1110             


Gln Glu  Pro Gly Gly Met Glu  Asp Ala Gln Gly Pro  Glu Pro Gly 
    1115                 1120                 1125             


Gln Ala  Arg Leu Gln Asp Trp  Glu Asp Gln Val Arg  Cys Asp Ile 
    1130                 1135                 1140             


Arg Gln  Phe Leu Ser Leu Arg  Pro Glu Glu Lys Phe  Ser Ser Arg 
    1145                 1150                 1155             


Ala Val  Ala Arg Ile Phe His  Gly Ile Gly Ser Pro  Cys Tyr Pro 
    1160                 1165                 1170             


Ala Gln  Val Tyr Gly Gln Asp  Arg Arg Phe Trp Arg  Lys Tyr Leu 
    1175                 1180                 1185             


His Leu  Ser Phe His Ala Leu  Val Gly Leu Ala Thr  Glu Glu Leu 
    1190                 1195                 1200             


Leu Gln  Val Ala Arg 
    1205             


<210> 63
<211> 1101
<212> PRT
<213> Homo sapiens

<400> 63
Met Asp Glu Cys Gly Ser Arg Ile Arg Arg Arg Val Ser Leu Pro Lys 
1               5                   10                  15      


Arg Asn Arg Pro Ser Leu Gly Cys Ile Phe Gly Ala Pro Thr Ala Ala 
            20                  25                  30          


Glu Leu Val Pro Gly Asp Glu Gly Lys Glu Glu Glu Glu Met Val Ala 
        35                  40                  45              


Glu Asn Arg Arg Arg Lys Thr Ala Gly Val Leu Pro Val Glu Val Gln 
    50                  55                  60                  


Pro Leu Leu Leu Ser Asp Ser Pro Glu Cys Leu Val Leu Gly Gly Gly 
65                  70                  75                  80  


Asp Thr Asn Pro Asp Leu Leu Arg His Met Pro Thr Asp Arg Gly Val 
                85                  90                  95      


Gly Asp Gln Pro Asn Asp Ser Glu Val Asp Met Phe Gly Asp Tyr Asp 
            100                 105                 110         


Ser Phe Thr Glu Asn Ser Phe Ile Ala Gln Val Asp Asp Leu Glu Gln 
        115                 120                 125             


Lys Tyr Met Gln Leu Pro Glu His Lys Lys His Ala Thr Asp Phe Ala 
    130                 135                 140                 


Thr Glu Asn Leu Cys Ser Glu Ser Ile Lys Asn Lys Leu Ser Ile Thr 
145                 150                 155                 160 


Thr Ile Gly Asn Leu Thr Glu Leu Gln Thr Asp Lys His Thr Glu Asn 
                165                 170                 175     


Gln Ser Gly Tyr Glu Gly Val Thr Ile Glu Pro Gly Ala Asp Leu Leu 
            180                 185                 190         


Tyr Asp Val Pro Ser Ser Gln Ala Ile Tyr Phe Glu Asn Leu Gln Asn 
        195                 200                 205             


Ser Ser Asn Asp Leu Gly Asp His Ser Met Lys Glu Arg Asp Trp Lys 
    210                 215                 220                 


Ser Ser Ser His Asn Thr Val Asn Glu Glu Leu Pro His Asn Cys Ile 
225                 230                 235                 240 


Glu Gln Pro Gln Gln Asn Asp Glu Ser Ser Ser Lys Val Arg Thr Ser 
                245                 250                 255     


Ser Asp Met Asn Arg Arg Lys Ser Ile Lys Asp His Leu Lys Asn Ala 
            260                 265                 270         


Met Thr Gly Asn Ala Lys Ala Gln Thr Pro Ile Phe Ser Arg Ser Lys 
        275                 280                 285             


Gln Leu Lys Asp Thr Leu Leu Ser Glu Glu Ile Asn Val Ala Lys Lys 
    290                 295                 300                 


Thr Val Glu Ser Ser Ser Asn Asp Leu Gly Pro Phe Tyr Ser Leu Pro 
305                 310                 315                 320 


Ser Lys Val Arg Asp Leu Tyr Ala Gln Phe Lys Gly Ile Glu Lys Leu 
                325                 330                 335     


Tyr Glu Trp Gln His Thr Cys Leu Thr Leu Asn Ser Val Gln Glu Arg 
            340                 345                 350         


Lys Asn Leu Ile Tyr Ser Leu Pro Thr Ser Gly Gly Lys Thr Leu Val 
        355                 360                 365             


Ala Glu Ile Leu Met Leu Gln Glu Leu Leu Cys Cys Arg Lys Asp Val 
    370                 375                 380                 


Leu Met Ile Leu Pro Tyr Val Ala Ile Val Gln Glu Lys Ile Ser Gly 
385                 390                 395                 400 


Leu Ser Ser Phe Gly Ile Glu Leu Gly Phe Phe Val Glu Glu Tyr Ala 
                405                 410                 415     


Gly Ser Lys Gly Arg Phe Pro Pro Thr Lys Arg Arg Glu Lys Lys Ser 
            420                 425                 430         


Leu Tyr Ile Ala Thr Ile Glu Lys Gly His Ser Leu Val Asn Ser Leu 
        435                 440                 445             


Ile Glu Thr Gly Arg Ile Asp Ser Leu Gly Leu Val Val Val Asp Glu 
    450                 455                 460                 


Leu His Met Ile Gly Glu Gly Ser Arg Gly Ala Thr Leu Glu Met Thr 
465                 470                 475                 480 


Leu Ala Lys Ile Leu Tyr Thr Ser Lys Thr Thr Gln Ile Ile Gly Met 
                485                 490                 495     


Ser Ala Thr Leu Asn Asn Val Glu Asp Leu Gln Lys Phe Leu Gln Ala 
            500                 505                 510         


Glu Tyr Tyr Thr Ser Gln Phe Arg Pro Val Glu Leu Lys Glu Tyr Leu 
        515                 520                 525             


Lys Ile Asn Asp Thr Ile Tyr Glu Val Asp Ser Lys Ala Glu Asn Gly 
    530                 535                 540                 


Met Thr Phe Ser Arg Leu Leu Asn Tyr Lys Tyr Ser Asp Thr Leu Lys 
545                 550                 555                 560 


Lys Met Asp Pro Asp His Leu Val Ala Leu Val Thr Glu Val Ile Pro 
                565                 570                 575     


Asn Tyr Ser Cys Leu Val Phe Cys Pro Ser Lys Lys Asn Cys Glu Asn 
            580                 585                 590         


Val Ala Glu Met Ile Cys Lys Phe Leu Ser Lys Glu Tyr Leu Lys His 
        595                 600                 605             


Lys Glu Lys Glu Lys Cys Glu Val Ile Lys Asn Leu Lys Asn Ile Gly 
    610                 615                 620                 


Asn Gly Asn Leu Cys Pro Val Leu Lys Arg Thr Ile Pro Phe Gly Val 
625                 630                 635                 640 


Ala Tyr His His Ser Gly Leu Thr Ser Asp Glu Arg Lys Leu Leu Glu 
                645                 650                 655     


Glu Ala Tyr Ser Thr Gly Val Leu Cys Leu Phe Thr Cys Thr Ser Thr 
            660                 665                 670         


Leu Ala Ala Gly Val Asn Leu Pro Ala Arg Arg Val Ile Leu Arg Ala 
        675                 680                 685             


Pro Tyr Val Ala Lys Glu Phe Leu Lys Arg Asn Gln Tyr Lys Gln Met 
    690                 695                 700                 


Ile Gly Arg Ala Gly Arg Ala Gly Ile Asp Thr Ile Gly Glu Ser Ile 
705                 710                 715                 720 


Leu Ile Leu Gln Glu Lys Asp Lys Gln Gln Val Leu Glu Leu Ile Thr 
                725                 730                 735     


Lys Pro Leu Glu Asn Cys Tyr Ser His Leu Val Gln Glu Phe Thr Lys 
            740                 745                 750         


Gly Ile Gln Thr Leu Phe Leu Ser Leu Ile Gly Leu Lys Ile Ala Thr 
        755                 760                 765             


Asn Leu Asp Asp Ile Tyr His Phe Met Asn Gly Thr Phe Phe Gly Val 
    770                 775                 780                 


Gln Gln Lys Val Leu Leu Lys Glu Lys Ser Leu Trp Glu Ile Thr Val 
785                 790                 795                 800 


Glu Ser Leu Arg Tyr Leu Thr Glu Lys Gly Leu Leu Gln Lys Asp Thr 
                805                 810                 815     


Ile Tyr Lys Ser Glu Glu Glu Val Gln Tyr Asn Phe His Ile Thr Lys 
            820                 825                 830         


Leu Gly Arg Ala Ser Phe Lys Gly Thr Ile Asp Leu Ala Tyr Cys Asp 
        835                 840                 845             


Ile Leu Tyr Arg Asp Leu Lys Lys Gly Leu Glu Gly Leu Val Leu Glu 
    850                 855                 860                 


Ser Leu Leu His Leu Ile Tyr Leu Thr Thr Pro Tyr Asp Leu Val Ser 
865                 870                 875                 880 


Gln Cys Asn Pro Asp Trp Met Ile Tyr Phe Arg Gln Phe Ser Gln Leu 
                885                 890                 895     


Ser Pro Ala Glu Gln Asn Val Ala Ala Ile Leu Gly Val Ser Glu Ser 
            900                 905                 910         


Phe Ile Gly Lys Lys Ala Ser Gly Gln Ala Ile Gly Lys Lys Val Asp 
        915                 920                 925             


Lys Asn Val Val Asn Arg Leu Tyr Leu Ser Phe Val Leu Tyr Thr Leu 
    930                 935                 940                 


Leu Lys Glu Thr Asn Ile Trp Thr Val Ser Glu Lys Phe Asn Met Pro 
945                 950                 955                 960 


Arg Gly Tyr Ile Gln Asn Leu Leu Thr Gly Thr Ala Ser Phe Ser Ser 
                965                 970                 975     


Cys Val Leu His Phe Cys Glu Glu Leu Glu Glu Phe Trp Val Tyr Arg 
            980                 985                 990         


Ala Leu Leu Val Glu Leu Thr Lys  Lys Leu Thr Tyr Cys  Val Lys Ala 
        995                 1000                 1005             


Glu Leu  Ile Pro Leu Met Glu  Val Thr Gly Val Leu  Glu Gly Arg 
    1010                 1015                 1020             


Ala Lys  Gln Leu Tyr Ser Ala  Gly Tyr Lys Ser Leu  Met His Leu 
    1025                 1030                 1035             


Ala Asn  Ala Asn Pro Glu Val  Leu Val Arg Thr Ile  Asp His Leu 
    1040                 1045                 1050             


Ser Arg  Arg Gln Ala Lys Gln  Ile Val Ser Ser Ala  Lys Met Leu 
    1055                 1060                 1065             


Leu His  Glu Lys Ala Glu Ala  Leu Gln Glu Glu Val  Glu Glu Leu 
    1070                 1075                 1080             


Leu Arg  Leu Pro Ser Asp Phe  Pro Gly Ala Val Ala  Ser Ser Thr 
    1085                 1090                 1095             


Asp Lys  Ala 
    1100     


<210> 64
<211> 1196
<212> PRT
<213> Herpes simplex virus 

<400> 64
Met Glu Thr Lys Pro Lys Thr Ala Thr Thr Ile Lys Val Pro Pro Gly 
1               5                   10                  15      


Pro Leu Gly Tyr Val Tyr Ala Arg Ala Cys Pro Ser Glu Gly Ile Glu 
            20                  25                  30          


Leu Leu Ala Leu Leu Ser Ala Arg Ser Gly Asp Ser Asp Val Ala Val 
        35                  40                  45              


Ala Pro Leu Val Val Gly Leu Thr Val Glu Ser Gly Phe Glu Ala Asn 
    50                  55                  60                  


Val Ala Val Val Val Gly Ser Arg Thr Thr Gly Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Val Ser Leu Lys Leu Thr Pro Ser His Tyr Ser Ser Ser Val Tyr Val 
                85                  90                  95      


Phe His Gly Gly Arg His Leu Asp Pro Ser Thr Gln Ala Pro Asn Leu 
            100                 105                 110         


Thr Arg Leu Cys Glu Arg Ala Arg Arg His Phe Gly Phe Ser Asp Tyr 
        115                 120                 125             


Thr Pro Arg Pro Gly Asp Leu Lys His Glu Thr Thr Gly Glu Ala Leu 
    130                 135                 140                 


Cys Glu Arg Leu Gly Leu Asp Pro Asp Arg Ala Leu Leu Tyr Leu Val 
145                 150                 155                 160 


Val Thr Glu Gly Phe Lys Glu Ala Val Cys Ile Asn Asn Thr Phe Leu 
                165                 170                 175     


His Leu Gly Gly Ser Asp Lys Val Thr Ile Gly Gly Ala Glu Val His 
            180                 185                 190         


Arg Ile Pro Val Tyr Pro Leu Gln Leu Phe Met Pro Asp Phe Ser Arg 
        195                 200                 205             


Val Ile Ala Glu Pro Phe Asn Ala Asn His Arg Ser Ile Gly Glu Lys 
    210                 215                 220                 


Phe Thr Tyr Pro Leu Pro Phe Phe Asn Arg Pro Leu Asn Arg Leu Leu 
225                 230                 235                 240 


Phe Glu Ala Val Val Gly Pro Ala Ala Val Ala Leu Arg Cys Arg Asn 
                245                 250                 255     


Val Asp Ala Val Ala Arg Ala Ala Ala His Leu Ala Phe Asp Glu Asn 
            260                 265                 270         


His Glu Gly Ala Ala Leu Pro Ala Asp Ile Thr Phe Thr Ala Phe Glu 
        275                 280                 285             


Ala Ser Gln Gly Lys Thr Pro Arg Gly Gly Arg Asp Gly Gly Gly Lys 
    290                 295                 300                 


Gly Ala Ala Gly Gly Phe Glu Gln Arg Leu Ala Ser Val Met Ala Gly 
305                 310                 315                 320 


Asp Ala Ala Leu Ala Leu Glu Ser Ile Val Ser Met Ala Val Phe Asp 
                325                 330                 335     


Glu Pro Pro Thr Asp Ile Ser Ala Trp Pro Leu Phe Glu Gly Gln Asp 
            340                 345                 350         


Thr Ala Ala Ala Arg Ala Asn Ala Val Gly Ala Tyr Leu Ala Arg Ala 
        355                 360                 365             


Ala Gly Leu Val Gly Ala Met Val Phe Ser Thr Asn Ser Ala Leu His 
    370                 375                 380                 


Leu Thr Glu Val Asp Asp Ala Gly Pro Ala Asp Pro Lys Asp His Ser 
385                 390                 395                 400 


Lys Pro Ser Phe Tyr Arg Phe Phe Leu Val Pro Gly Thr His Val Ala 
                405                 410                 415     


Ala Asn Pro Gln Val Asp Arg Glu Gly His Val Val Pro Gly Phe Glu 
            420                 425                 430         


Gly Arg Pro Thr Ala Pro Leu Val Gly Gly Thr Gln Glu Phe Ala Gly 
        435                 440                 445             


Glu His Leu Ala Met Leu Cys Gly Phe Ser Pro Ala Leu Leu Ala Lys 
    450                 455                 460                 


Met Leu Phe Tyr Leu Glu Arg Cys Asp Gly Ala Val Ile Val Gly Arg 
465                 470                 475                 480 


Gln Glu Met Asp Val Phe Arg Tyr Val Ala Asp Ser Asn Gln Thr Asp 
                485                 490                 495     


Val Pro Cys Asn Leu Cys Thr Phe Asp Thr Arg His Ala Cys Val His 
            500                 505                 510         


Thr Thr Leu Met Arg Leu Arg Ala Arg His Pro Lys Phe Ala Ser Ala 
        515                 520                 525             


Ala Arg Gly Ala Ile Gly Val Phe Gly Thr Met Asn Ser Met Tyr Ser 
    530                 535                 540                 


Asp Cys Asp Val Leu Gly Asn Tyr Ala Ala Phe Ser Ala Leu Lys Arg 
545                 550                 555                 560 


Ala Asp Gly Ser Glu Thr Ala Arg Thr Ile Met Gln Glu Thr Tyr Arg 
                565                 570                 575     


Ala Ala Thr Glu Arg Val Met Ala Glu Leu Glu Thr Leu Gln Tyr Val 
            580                 585                 590         


Asp Gln Ala Val Pro Thr Ala Met Gly Arg Leu Glu Thr Ile Ile Thr 
        595                 600                 605             


Asn Arg Glu Ala Leu His Thr Val Val Asn Asn Val Arg Gln Val Val 
    610                 615                 620                 


Asp Arg Glu Val Glu Gln Leu Met Arg Asn Leu Val Glu Gly Arg Asn 
625                 630                 635                 640 


Phe Lys Phe Arg Asp Gly Leu Gly Glu Ala Asn His Ala Met Ser Leu 
                645                 650                 655     


Thr Leu Asp Pro Tyr Ala Cys Gly Pro Cys Pro Leu Leu Gln Leu Leu 
            660                 665                 670         


Gly Arg Arg Ser Asn Leu Ala Val Tyr Gln Asp Leu Ala Leu Ser Gln 
        675                 680                 685             


Cys His Gly Val Phe Ala Gly Gln Ser Val Glu Gly Arg Asn Phe Arg 
    690                 695                 700                 


Asn Gln Phe Gln Pro Val Leu Arg Arg Arg Val Met Asp Met Phe Asn 
705                 710                 715                 720 


Asn Gly Phe Leu Ser Ala Lys Thr Leu Thr Val Ala Leu Ser Glu Gly 
                725                 730                 735     


Ala Ala Ile Cys Ala Pro Ser Leu Thr Ala Gly Gln Thr Ala Pro Ala 
            740                 745                 750         


Glu Ser Ser Phe Glu Gly Asp Val Ala Arg Val Thr Leu Gly Phe Pro 
        755                 760                 765             


Lys Glu Leu Arg Val Lys Ser Arg Val Leu Phe Ala Gly Ala Ser Ala 
    770                 775                 780                 


Asn Ala Ser Glu Ala Ala Lys Ala Arg Val Ala Ser Leu Gln Ser Ala 
785                 790                 795                 800 


Tyr Gln Lys Pro Asp Lys Arg Val Asp Ile Leu Leu Gly Pro Leu Gly 
                805                 810                 815     


Phe Leu Leu Lys Gln Phe His Ala Ala Ile Phe Pro Asn Gly Lys Pro 
            820                 825                 830         


Pro Gly Ser Asn Gln Pro Asn Pro Gln Trp Phe Trp Thr Ala Leu Gln 
        835                 840                 845             


Arg Asn Gln Leu Pro Ala Arg Leu Leu Ser Arg Glu Asp Ile Glu Thr 
    850                 855                 860                 


Ile Ala Phe Ile Lys Lys Phe Ser Leu Asp Tyr Gly Ala Ile Asn Phe 
865                 870                 875                 880 


Ile Asn Leu Ala Pro Asn Asn Val Ser Glu Leu Ala Met Tyr Tyr Met 
                885                 890                 895     


Ala Asn Gln Ile Leu Arg Tyr Cys Asp His Ser Thr Tyr Phe Ile Asn 
            900                 905                 910         


Thr Leu Thr Ala Ile Ile Ala Gly Ser Arg Arg Pro Pro Ser Val Gln 
        915                 920                 925             


Ala Ala Ala Ala Trp Ser Ala Gln Gly Gly Ala Gly Leu Glu Ala Gly 
    930                 935                 940                 


Ala Arg Ala Leu Met Asp Ala Val Asp Ala His Pro Gly Ala Trp Thr 
945                 950                 955                 960 


Ser Met Phe Ala Ser Cys Asn Leu Leu Arg Pro Val Met Ala Ala Arg 
                965                 970                 975     


Pro Met Val Val Leu Gly Leu Ser Ile Ser Lys Tyr Tyr Gly Met Ala 
            980                 985                 990         


Gly Asn Asp Arg Val Phe Gln Ala  Gly Asn Trp Ala Ser  Leu Met Gly 
        995                 1000                 1005             


Gly Lys  Asn Ala Cys Pro Leu  Leu Ile Phe Asp Arg  Thr Arg Lys 
    1010                 1015                 1020             


Phe Val  Leu Ala Cys Pro Arg  Ala Gly Phe Val Cys  Ala Ala Ser 
    1025                 1030                 1035             


Ser Leu  Gly Gly Gly Ala His  Glu Ser Ser Leu Cys  Glu Gln Leu 
    1040                 1045                 1050             


Arg Gly  Ile Ile Ser Glu Gly  Gly Ala Ala Val Ala  Ser Ser Val 
    1055                 1060                 1065             


Phe Val  Ala Thr Val Lys Ser  Leu Gly Pro Arg Thr  Gln Gln Leu 
    1070                 1075                 1080             


Gln Ile  Glu Asp Trp Leu Ala  Leu Leu Glu Asp Glu  Tyr Leu Ser 
    1085                 1090                 1095             


Glu Glu  Met Met Glu Leu Thr  Ala Arg Ala Leu Glu  Arg Gly Asn 
    1100                 1105                 1110             


Gly Glu  Trp Ser Thr Asp Ala  Ala Leu Glu Val Ala  His Glu Ala 
    1115                 1120                 1125             


Glu Ala  Leu Val Ser Gln Leu  Gly Asn Ala Gly Glu  Val Phe Asn 
    1130                 1135                 1140             


Phe Gly  Asp Phe Gly Cys Glu  Asp Asp Asn Ala Thr  Pro Phe Gly 
    1145                 1150                 1155             


Gly Pro  Gly Ala Pro Gly Pro  Ala Phe Ala Gly Arg  Lys Arg Ala 
    1160                 1165                 1170             


Phe His  Gly Asp Asp Pro Phe  Gly Glu Gly Pro Pro  Asp Lys Lys 
    1175                 1180                 1185             


Gly Asp  Leu Thr Leu Asp Met  Leu 
    1190                 1195     


<210> 65
<211> 843
<212> PRT
<213> Saccharomyces cerevisiae

<400> 65
Met Thr Asp Val Glu Gly Tyr Gln Pro Lys Ser Lys Gly Lys Ile Phe 
1               5                   10                  15      


Pro Asp Met Gly Glu Ser Phe Phe Ser Ser Asp Glu Asp Ser Pro Ala 
            20                  25                  30          


Thr Asp Ala Glu Ile Asp Glu Asn Tyr Asp Asp Asn Arg Glu Thr Ser 
        35                  40                  45              


Glu Gly Arg Gly Glu Arg Asp Thr Gly Ala Met Val Thr Gly Leu Lys 
    50                  55                  60                  


Lys Pro Arg Lys Lys Thr Lys Ser Ser Arg His Thr Ala Ala Asp Ser 
65                  70                  75                  80  


Ser Met Asn Gln Met Asp Ala Lys Asp Lys Ala Leu Leu Gln Asp Thr 
                85                  90                  95      


Asn Ser Asp Ile Pro Ala Asp Phe Val Pro Asp Ser Val Ser Gly Met 
            100                 105                 110         


Phe Arg Ser His Asp Phe Ser Tyr Leu Arg Leu Arg Pro Asp His Ala 
        115                 120                 125             


Ser Arg Pro Leu Trp Ile Ser Pro Ser Asp Gly Arg Ile Ile Leu Glu 
    130                 135                 140                 


Ser Phe Ser Pro Leu Ala Glu Gln Ala Gln Asp Phe Leu Val Thr Ile 
145                 150                 155                 160 


Ala Glu Pro Ile Ser Arg Pro Ser His Ile His Glu Tyr Lys Ile Thr 
                165                 170                 175     


Ala Tyr Ser Leu Tyr Ala Ala Val Ser Val Gly Leu Glu Thr Asp Asp 
            180                 185                 190         


Ile Ile Ser Val Leu Asp Arg Leu Ser Lys Val Pro Val Ala Glu Ser 
        195                 200                 205             


Ile Ile Asn Phe Ile Lys Gly Ala Thr Ile Ser Tyr Gly Lys Val Lys 
    210                 215                 220                 


Leu Val Ile Lys His Asn Arg Tyr Phe Val Glu Thr Thr Gln Ala Asp 
225                 230                 235                 240 


Ile Leu Gln Met Leu Leu Asn Asp Ser Val Ile Gly Pro Leu Arg Ile 
                245                 250                 255     


Asp Ser Asp His Gln Val Gln Pro Pro Glu Asp Val Leu Gln Gln Gln 
            260                 265                 270         


Leu Gln Gln Thr Ala Gly Lys Pro Ala Thr Asn Val Asn Pro Asn Asp 
        275                 280                 285             


Val Glu Ala Val Phe Ser Ala Val Ile Gly Gly Asp Asn Glu Arg Glu 
    290                 295                 300                 


Glu Glu Asp Asp Asp Ile Asp Ala Val His Ser Phe Glu Ile Ala Asn 
305                 310                 315                 320 


Glu Ser Val Glu Val Val Lys Lys Arg Cys Gln Glu Ile Asp Tyr Pro 
                325                 330                 335     


Val Leu Glu Glu Tyr Asp Phe Arg Asn Asp His Arg Asn Pro Asp Leu 
            340                 345                 350         


Asp Ile Asp Leu Lys Pro Ser Thr Gln Ile Arg Pro Tyr Gln Glu Lys 
        355                 360                 365             


Ser Leu Ser Lys Met Phe Gly Asn Gly Arg Ala Arg Ser Gly Ile Ile 
    370                 375                 380                 


Val Leu Pro Cys Gly Ala Gly Lys Thr Leu Val Gly Ile Thr Ala Ala 
385                 390                 395                 400 


Cys Thr Ile Lys Lys Ser Val Ile Val Leu Cys Thr Ser Ser Val Ser 
                405                 410                 415     


Val Met Gln Trp Arg Gln Gln Phe Leu Gln Trp Cys Thr Leu Gln Pro 
            420                 425                 430         


Glu Asn Cys Ala Val Phe Thr Ser Asp Asn Lys Glu Met Phe Gln Thr 
        435                 440                 445             


Glu Ser Gly Leu Val Val Ser Thr Tyr Ser Met Val Ala Asn Thr Arg 
    450                 455                 460                 


Asn Arg Ser His Asp Ser Gln Lys Val Met Asp Phe Leu Thr Gly Arg 
465                 470                 475                 480 


Glu Trp Gly Phe Ile Ile Leu Asp Glu Val His Val Val Pro Ala Ala 
                485                 490                 495     


Met Phe Arg Arg Val Val Ser Thr Ile Ala Ala His Ala Lys Leu Gly 
            500                 505                 510         


Leu Thr Ala Thr Leu Val Arg Glu Asp Asp Lys Ile Gly Asp Leu Asn 
        515                 520                 525             


Phe Leu Ile Gly Pro Lys Leu Tyr Glu Ala Asn Trp Met Glu Leu Ser 
    530                 535                 540                 


Gln Lys Gly His Ile Ala Asn Val Gln Cys Ala Glu Val Trp Cys Pro 
545                 550                 555                 560 


Met Thr Ala Glu Phe Tyr Gln Glu Tyr Leu Arg Glu Thr Ala Arg Lys 
                565                 570                 575     


Arg Met Leu Leu Tyr Ile Met Asn Pro Thr Lys Phe Gln Ala Cys Gln 
            580                 585                 590         


Phe Leu Ile Gln Tyr His Glu Arg Arg Gly Asp Lys Ile Ile Val Phe 
        595                 600                 605             


Ser Asp Asn Val Tyr Ala Leu Gln Glu Tyr Ala Leu Lys Met Gly Lys 
    610                 615                 620                 


Pro Phe Ile Tyr Gly Ser Thr Pro Gln Gln Glu Arg Met Asn Ile Leu 
625                 630                 635                 640 


Gln Asn Phe Gln Tyr Asn Asp Gln Ile Asn Thr Ile Phe Leu Ser Lys 
                645                 650                 655     


Val Gly Asp Thr Ser Ile Asp Leu Pro Glu Ala Thr Cys Leu Ile Gln 
            660                 665                 670         


Ile Ser Ser His Tyr Gly Ser Arg Arg Gln Glu Ala Gln Arg Leu Gly 
        675                 680                 685             


Arg Ile Leu Arg Ala Lys Arg Arg Asn Asp Glu Gly Phe Asn Ala Phe 
    690                 695                 700                 


Phe Tyr Ser Leu Val Ser Lys Asp Thr Gln Glu Met Tyr Tyr Ser Thr 
705                 710                 715                 720 


Lys Arg Gln Ala Phe Leu Val Asp Gln Gly Tyr Ala Phe Lys Val Ile 
                725                 730                 735     


Thr His Leu His Gly Met Glu Asn Ile Pro Asn Leu Ala Tyr Ala Ser 
            740                 745                 750         


Pro Arg Glu Arg Arg Glu Leu Leu Gln Glu Val Leu Leu Lys Asn Glu 
        755                 760                 765             


Glu Ala Ala Gly Ile Glu Val Gly Asp Asp Ala Asp Asn Ser Val Gly 
    770                 775                 780                 


Arg Gly Ser Asn Gly His Lys Arg Phe Lys Ser Lys Ala Val Arg Gly 
785                 790                 795                 800 


Glu Gly Ser Leu Ser Gly Leu Ala Gly Gly Glu Asp Met Ala Tyr Met 
                805                 810                 815     


Glu Tyr Ser Thr Asn Lys Asn Lys Glu Leu Lys Glu His His Pro Leu 
            820                 825                 830         


Ile Arg Lys Met Tyr Tyr Lys Asn Leu Lys Lys 
        835                 840             


<210> 66
<211> 778
<212> PRT
<213> Saccharomyces cerevisiae

<400> 66
Met Lys Phe Tyr Ile Asp Asp Leu Pro Val Leu Phe Pro Tyr Pro Lys 
1               5                   10                  15      


Ile Tyr Pro Glu Gln Tyr Asn Tyr Met Cys Asp Ile Lys Lys Thr Leu 
            20                  25                  30          


Asp Val Gly Gly Asn Ser Ile Leu Glu Met Pro Ser Gly Thr Gly Lys 
        35                  40                  45              


Thr Val Ser Leu Leu Ser Leu Thr Ile Ala Tyr Gln Met His Tyr Pro 
    50                  55                  60                  


Glu His Arg Lys Ile Ile Tyr Cys Ser Arg Thr Met Ser Glu Ile Glu 
65                  70                  75                  80  


Lys Ala Leu Val Glu Leu Glu Asn Leu Met Asp Tyr Arg Thr Lys Glu 
                85                  90                  95      


Leu Gly Tyr Gln Glu Asp Phe Arg Gly Leu Gly Leu Thr Ser Arg Lys 
            100                 105                 110         


Asn Leu Cys Leu His Pro Glu Val Ser Lys Glu Arg Lys Gly Thr Val 
        115                 120                 125             


Val Asp Glu Lys Cys Arg Arg Met Thr Asn Gly Gln Ala Lys Arg Lys 
    130                 135                 140                 


Leu Glu Glu Asp Pro Glu Ala Asn Val Glu Leu Cys Glu Tyr His Glu 
145                 150                 155                 160 


Asn Leu Tyr Asn Ile Glu Val Glu Asp Tyr Leu Pro Lys Gly Val Phe 
                165                 170                 175     


Ser Phe Glu Lys Leu Leu Lys Tyr Cys Glu Glu Lys Thr Leu Cys Pro 
            180                 185                 190         


Tyr Phe Ile Val Arg Arg Met Ile Ser Leu Cys Asn Ile Ile Ile Tyr 
        195                 200                 205             


Ser Tyr His Tyr Leu Leu Asp Pro Lys Ile Ala Glu Arg Val Ser Asn 
    210                 215                 220                 


Glu Val Ser Lys Asp Ser Ile Val Ile Phe Asp Glu Ala His Asn Ile 
225                 230                 235                 240 


Asp Asn Val Cys Ile Glu Ser Leu Ser Leu Asp Leu Thr Thr Asp Ala 
                245                 250                 255     


Leu Arg Arg Ala Thr Arg Gly Ala Asn Ala Leu Asp Glu Arg Ile Ser 
            260                 265                 270         


Glu Val Arg Lys Val Asp Ser Gln Lys Leu Gln Asp Glu Tyr Glu Lys 
        275                 280                 285             


Leu Val Gln Gly Leu His Ser Ala Asp Ile Leu Thr Asp Gln Glu Glu 
    290                 295                 300                 


Pro Phe Val Glu Thr Pro Val Leu Pro Gln Asp Leu Leu Thr Glu Ala 
305                 310                 315                 320 


Ile Pro Gly Asn Ile Arg Arg Ala Glu His Phe Val Ser Phe Leu Lys 
                325                 330                 335     


Arg Leu Ile Glu Tyr Leu Lys Thr Arg Met Lys Val Leu His Val Ile 
            340                 345                 350         


Ser Glu Thr Pro Lys Ser Phe Leu Gln His Leu Lys Gln Leu Thr Phe 
        355                 360                 365             


Ile Glu Arg Lys Pro Leu Arg Phe Cys Ser Glu Arg Leu Ser Leu Leu 
    370                 375                 380                 


Val Arg Thr Leu Glu Val Thr Glu Val Glu Asp Phe Thr Ala Leu Lys 
385                 390                 395                 400 


Asp Ile Ala Thr Phe Ala Thr Leu Ile Ser Thr Tyr Glu Glu Gly Phe 
                405                 410                 415     


Leu Leu Ile Ile Glu Pro Tyr Glu Ile Glu Asn Ala Ala Val Pro Asn 
            420                 425                 430         


Pro Ile Met Arg Phe Thr Cys Leu Asp Ala Ser Ile Ala Ile Lys Pro 
        435                 440                 445             


Val Phe Glu Arg Phe Ser Ser Val Ile Ile Thr Ser Gly Thr Ile Ser 
    450                 455                 460                 


Pro Leu Asp Met Tyr Pro Arg Met Leu Asn Phe Lys Thr Val Leu Gln 
465                 470                 475                 480 


Lys Ser Tyr Ala Met Thr Leu Ala Lys Lys Ser Phe Leu Pro Met Ile 
                485                 490                 495     


Ile Thr Lys Gly Ser Asp Gln Val Ala Ile Ser Ser Arg Phe Glu Ile 
            500                 505                 510         


Arg Asn Asp Pro Ser Ile Val Arg Asn Tyr Gly Ser Met Leu Val Glu 
        515                 520                 525             


Phe Ala Lys Ile Thr Pro Asp Gly Met Val Val Phe Phe Pro Ser Tyr 
    530                 535                 540                 


Leu Tyr Met Glu Ser Ile Val Ser Met Trp Gln Thr Met Gly Ile Leu 
545                 550                 555                 560 


Asp Glu Val Trp Lys His Lys Leu Ile Leu Val Glu Thr Pro Asp Ala 
                565                 570                 575     


Gln Glu Thr Ser Leu Ala Leu Glu Thr Tyr Arg Lys Ala Cys Ser Asn 
            580                 585                 590         


Gly Arg Gly Ala Ile Leu Leu Ser Val Ala Arg Gly Lys Val Ser Glu 
        595                 600                 605             


Gly Ile Asp Phe Asp His Gln Tyr Gly Arg Thr Val Leu Met Ile Gly 
    610                 615                 620                 


Ile Pro Phe Gln Tyr Thr Glu Ser Arg Ile Leu Lys Ala Arg Leu Glu 
625                 630                 635                 640 


Phe Met Arg Glu Asn Tyr Arg Ile Arg Glu Asn Asp Phe Leu Ser Phe 
                645                 650                 655     


Asp Ala Met Arg His Ala Ala Gln Cys Leu Gly Arg Val Leu Arg Gly 
            660                 665                 670         


Lys Asp Asp Tyr Gly Val Met Val Leu Ala Asp Arg Arg Phe Ser Arg 
        675                 680                 685             


Lys Arg Ser Gln Leu Pro Lys Trp Ile Ala Gln Gly Leu Ser Asp Ala 
    690                 695                 700                 


Asp Leu Asn Leu Ser Thr Asp Met Ala Ile Ser Asn Thr Lys Gln Phe 
705                 710                 715                 720 


Leu Arg Thr Met Ala Gln Pro Thr Asp Pro Lys Asp Gln Glu Gly Val 
                725                 730                 735     


Ser Val Trp Ser Tyr Glu Asp Leu Ile Lys His Gln Asn Ser Arg Lys 
            740                 745                 750         


Asp Gln Gly Gly Phe Ile Glu Asn Glu Asn Lys Glu Gly Glu Gln Asp 
        755                 760                 765             


Glu Asp Glu Asp Glu Asp Ile Glu Met Gln 
    770                 775             


<210> 67
<211> 129
<212> PRT
<213> Streptococcus pyogenes

<400> 67
Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu 
1               5                   10                  15      


Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile 
            20                  25                  30          


Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala 
        35                  40                  45              


Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala 
    50                  55                  60                  


Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala 
65                  70                  75                  80  


Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu 
                85                  90                  95      


Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu 
            100                 105                 110         


Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg 
        115                 120                 125             


Val 
    


<210> 68
<211> 625
<212> PRT
<213> Streptococcus pyogenes

<400> 68
Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
1               5                   10                  15      


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
            20                  25                  30          


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
        35                  40                  45              


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
    50                  55                  60                  


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
65                  70                  75                  80  


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
                85                  90                  95      


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
            100                 105                 110         


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
        115                 120                 125             


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
    130                 135                 140                 


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
145                 150                 155                 160 


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
                165                 170                 175     


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
            180                 185                 190         


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
        195                 200                 205             


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
    210                 215                 220                 


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
225                 230                 235                 240 


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
                245                 250                 255     


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
            260                 265                 270         


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
        275                 280                 285             


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
    290                 295                 300                 


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
305                 310                 315                 320 


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
                325                 330                 335     


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
            340                 345                 350         


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
        355                 360                 365             


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
    370                 375                 380                 


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
385                 390                 395                 400 


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
                405                 410                 415     


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
            420                 425                 430         


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
        435                 440                 445             


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
    450                 455                 460                 


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
465                 470                 475                 480 


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
                485                 490                 495     


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
            500                 505                 510         


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
        515                 520                 525             


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
    530                 535                 540                 


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
545                 550                 555                 560 


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
                565                 570                 575     


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
            580                 585                 590         


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
        595                 600                 605             


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
    610                 615                 620                 


Asp 
625 


<210> 69
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(49)
<223> a, c, t, g, unknown or other

<400> 69
nnnnnnnnnn nnnnntctct nnnnnnnnnn nnnnnnnnnn nnnnnnnnn                   49


<210> 70
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(49)
<223> a, c, t, g, unknown or other

<400> 70
nnnnnnnnnn nnnnntctct nnnnnnnnnn nnnnnnnnnn nnnnnnnnn                   49


<210> 71
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(25)
<223> a, c, t, g, unknown or other

<400> 71
nnnnnnnnnn tctctnnnnn nnnnn                                             25


<210> 72
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(10)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (16)..(25)
<223> a, c, t, g, unknown or other

<400> 72
nnnnnnnnnn tctctnnnnn nnnnn                                             25


<210> 73
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (6)..(10)
<223> a, c, t, g, unknown or other

<400> 73
gtrhgnnnnn                                                              10


<210> 74
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (11)..(11)
<223> a, c, t, g, unknown or other

<400> 74
yyyyyyyyyy nyag                                                         14


<210> 75
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      'LAGLIDADG' family motif peptide

<400> 75
Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210> 76
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Leu Arg Gly Ser 
1               


<210> 77
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(21)
<223> a, c, t, g, unknown or other

<400> 77
nnnaaaannn nnnnnnnnnn ngg                                               23


<210> 78
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
gtgctgacca tcgacgagaa agggactgaa gctgctgggg ccatgttttt agaggccat        59


<210> 79
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Leu Asn Tyr Gly Val Cys Phe Cys Gly 
1               5                   


<210> 80
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(49)
<223> a, c, t, g, unknown or other

<400> 80
nnnnnnnnnn nnnnntctct nnnnnnnnnn nnnnnnnnnn nnnnnnnnn                   49


<210> 81
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
caaatgcttg tgagaaagct tgctca                                            26


<210> 82
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Gln Ser Ser Asp Leu Ser Arg 
1               5           


<210> 83
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Leu Lys Trp Asn Leu Arg Thr 
1               5           


<210> 84
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Arg Ser Asp Asn Leu Ala Arg 
1               5           


<210> 85
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Trp Gln Ser Ser Leu Ile Val 
1               5           


<210> 86
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Gln Ser Gly Asn Arg Thr Thr 
1               5           


<210> 87
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
atgcttgtga gaaagcttgc tcatca                                            26


<210> 88
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
cttgtgagaa agcttgctca tcatac                                            26


<210> 89
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 89
Thr Asn Gln Asn Arg Ile Thr 
1               5           


<210> 90
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Arg Ser Ala Asn Leu Thr Arg 
1               5           


<210> 91
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 91
gtgagaaagc ttgctcatca tacttg                                            26


<210> 92
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 92
Ala His Gly Ala Arg Trp Asn 
1               5           

