                         SEQUENCE LISTING

<110>  AMICUS THERAPEUTICS, INC.
 
<120>  METHODS OF TREATING FABRY DISEASE IN PATIENTS HAVING A MUTATION 
       IN THE GLA GENE

<130>  AT18-005-PCT

<150>  US 62/719,962
<151>  2018-08-20

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  12436
<212>  DNA
<213>  Homo sapiens

<400>  1
cccttctgta ggggcagaga ggttctactt cattactgcg tctcctggga aggccatcag       60

gactgctggc taaagtggga accaggactc tttgtgagtt aagaatttgt gtatttatat      120

gtgtgttata cacatttttt aaaaaactgt aacgacatca ggttgagcag tcgtctccgg      180

gtggtgaatt atgtgtattt ttaaatttta tactatattg ttatttttca aatgttcgaa      240

attgaatatg tagattgttg ttatcagcag aaaaataaac attattcaaa tactctattc      300

agtaaagtaa tttattgggc gcctttgtca agcacgcatt tgcctagatg tgactctaca      360

gataaaattc acttggggcc tccccttaca gacaatcagg cagtggagac tgagtgcctg      420

aatggataga ccagcactca gaccactatt ttcagtatct gtttttctta actcagggcc      480

gtggttttca aacgtttttc gccttacggt cacccttagg gtcccccgag accggcccag      540

acagacagat atacaaaaac acatacacag tcatgagcgt ccaccatttc cccaccaggc      600

gcagcacagg cggcttcccg gcactgagat gggggggagg agggagagag cgcgaggggg      660

gaggggaaag cagagaacga aagaggcgga ggcggccccc gaaccccgct ctggtcttca      720

tcatcaccac ccctgggtcc ccagttccca cccacacacc aacctctaac gataccgggt      780

aattttcctc cttcttccct caaacggcta tagcgagacg gtagacgacg accagaacta      840

cttctgctca cgtaagcgag taatcacgtg agcgcctacg tcatgtgaga tctcggtcac      900

gtgagcaact ctcggcttaa actcgggatc actaaggtgc cgcacttcct tctggtatgg      960

aaatagggcg ggtcaatatc aagaaaggaa gagggtgatt ggttagcgga acgtcttacg     1020

tgactgatta ttggtctacc tctggggata accgtcccag ttgccagaga aacaataacg     1080

tcattattta ataagtcatc ggtgattggt ccgcccctga ggttaatctt aaaagcccag     1140

gttacccgcg gaaatttatg ctgtccggtc accgtgacaa tgcagctgag gaacccagaa     1200

ctacatctgg gctgcgcgct tgcgcttcgc ttcctggccc tcgtttcctg ggacatccct     1260

ggggctagag cactggacaa tggattggca aggacgccta ccatgggctg gctgcactgg     1320

gagcgcttca tgtgcaacct tgactgccag gaagagccag attcctgcat caggtatcag     1380

atattgggta ctcccttccc tttgcttttc catgtgtttg ggtgtgtttg gggaactgga     1440

gagtctcaac gggaacagtt gagcccgagg gagagctccc ccacccgact ctgctgctgc     1500

ttttttatcc ccagcaaact gtcccgaatc aggactagcc ctaaactttc tctgtgtgac     1560

ctttcctggg atgggagtcc ggccagcggc ccctgtttct ttctctctct ctctctctct     1620

cgttctcctt ctctttctct ttctcttctt tcctctctct ttctctctct ccctgcccgg     1680

ttctcttttt tcactgctcc ttgcagagca gggccacccc ataggcagtg tgcccaaagt     1740

agccctgccc ggttctattc agacccttct tgtgaacttc tgctcttcct ctgccgggtg     1800

ctaaccgtta gaacatctag ggtgggtagg aggaatgggg aactaagatt cgtgccattt     1860

tttctccttt tggggtcgtg gatttctcgg cagtatctcg agggagttag agagaccata     1920

aggtcgctga gatctctccc acctcgccca tgagcgtggc atcaggctgg aaggttgaca     1980

tggaggaact ttatacattt acacctttgc gtgagggttg aggctggatt agataggtat     2040

tgaacatatc tgaccctcac aatccttatc tgtaaattgg gattacaacc ttttaatttc     2100

agggagctga caaaaaaaat ctgaaaaata gttcttatct cacacaggtg agttttcaag     2160

gagataacct atttaaagta catagcacag cgcttgacca ttcaactgcg cttacagagc     2220

aaatgttcaa tgggaaaatg aatgtaaatc tacaaatctg aatgaatatg tgtatttttc     2280

tggagagagg atatttacct ttcttcaaat tctcaaaggg ctctgtgatt taaaaaaggt     2340

taggaatcac tgatagatgt tggtaaaagg tggcagtcac agtacatttc tgtgtccata     2400

agttattcct atgaatatct ttatagataa agtcaggatg ttggtcagac atcacagaag     2460

aaattggcct tgtaagtttc atgtgaccct gtggtacagt atgtgtggca attttgccca     2520

tcacggattt ttttttattg gtatttgcat ctgattataa aactaatgca tgatcattgc     2580

aaaaaatgta gataaagaag agcaaaatga aaataaagat ttccccccac cgttccacca     2640

cccagaaata atcatggttt aaatgttaat atacaacctt acaattgttt tctatataaa     2700

tgaaaacata gatttcttta tttcattatt ttccataaaa aatggatcat gtttatgtca     2760

tgtttggcta atggcaagac cctggcaccc agtctgggct caaattctgc ctcattgtta     2820

cttagccctg tgacattggg taaattacac tttttttttt tttttttttt tgagacgggg     2880

tctcgctctg tcgcccaggc tggagtgcag tggcacgatc tcggctcact gcaagtccgc     2940

ctcctgggtt cacgccattc ttctgcctca gcctcccgag tagctgggac tacaggcgcc     3000

tgccaccacg cctggctctt tttttttttt tttttttttt tagtacagac ggggtttcac     3060

catgttagcc agggtggtct caatctcctg acctcgtgat tcgcccgcct cagcctccca     3120

aagtgctggt gtgagccacc gtgcccagcc ttactttttt ttttgagagg gggtctcact     3180

ctgtcaccca ggttggagtg cagtggcgcg atctctgctc agtgcaaact ccacctcccg     3240

ggtttaagca gttctcctgt cgtagtctcc tgagtagctg ggattacagg cacaccacca     3300

cggccagcta atttttgtat tttcagtaga gacgggtttc accatgttgc ccaagctggt     3360

ctcgaactcc tggcctcaag tgatctgccc gccttggcct cccagagtgc tgggattaca     3420

ggtgtgagcc accgcacccg gcctcttttt tcttttttag tctatcatac cttgcaaata     3480

cagtggttct tcctatgtgt tggttttgat atttatgtaa tcaaacacat cagtttttcc     3540

tttctgattt ctgactttgg ggtcatgctg agaaagtcct ttcctacctg aagataatac     3600

agtatatacg tttcttacta gtatttttgt ggatttttaa aatatttaaa tctttagtcc     3660

atctgaactt gttcttctat cagaaatgcc acatttaata aataataagt cccatggtat     3720

cagatggctg gaaggacctc tttcgaaact ttgtttaatt ccattaatct gtgtattctt     3780

attctaatgc taatagttcc acactagctt cctttatctt ttttttcttt tttttttttt     3840

ttttgagctg gagtttcgct cttgttgccc aggctggagt acaatgtcac gatctcggtt     3900

caccgcaacc tccgcctccc aggttcaagc aattctcctg cctcatcctc gcgagtagct     3960

ggaattacag gcatgcgcca ccacgcctag ctattttgta tttttagtag agatggggtt     4020

tctccatgtt ggtcaggctg gtctcaaact cccagcctca ggtgatctgc ctgcctcggc     4080

ctcccaaaat gctgttatta caggcgtgag ccaccacgcc cagccttcat cttttaatga     4140

atgtacatgt atgtaatctt ttaggtgaac tttttgtaat gttgtgccaa gttccttaaa     4200

aagccctttt ggaagctggg caggtggcca cgcctgtaat cccagcattt tgggagtctg     4260

aggcaggtgg atcacttgag gccaggagtt caagactagc ctagccaaaa tgcaaaaccc     4320

tgtctctact aaagatacaa aaattagccg gatgcgatgg cacatgcctg taatctcagc     4380

tactcgggag gctgaggtag aagaatcgct tgaaccgggg aggcagaggt tgcagtgagc     4440

aagatggcgc cactgcactc cagcctgggt gacagaggga gactccatct caaaaaaaaa     4500

aaaaaaaaaa aagataaaaa ggaaacctaa gtactcttgg gctttgttaa ggattttgtt     4560

aaatatacaa aggattgcag ggaaaattaa cttattttta atattgagta tgcttatcca     4620

agagcaaaat aatatttctc catttattca aatcatttag gagcatcata gttttaacat     4680

atgggccttg cacgtatctt aaatttatct ctaggcattt taggttgttc agttgttctt     4740

gtgaatggga tctttttctc caaataggat tattgttgat atctgttgat tatgttaact     4800

ttgtagtttc tgactttact gaactgtctt cttagatcta atactctttt caatttcatc     4860

atatatttct cattcctatt ttgtttgggg tttttagggc gggaatatta acgggataag     4920

agagacaaaa gaaaatctgg aaaaacaatt cattttacct tacattgctt gtgattacta     4980

ccacactatt actgggttgg aaaaaattgt gaaatcccaa ggtgcctaat aaatgggagg     5040

tacctaagtg ttcatttaat gaattgtaat gattattgga atttctcttt cagtgagaag     5100

ctcttcatgg agatggcaga gctcatggtc tcagaaggct ggaaggatgc aggttatgag     5160

tacctctgca ttgatgactg ttggatggct ccccaaagag attcagaagg cagacttcag     5220

gcagaccctc agcgctttcc tcatgggatt cgccagctag ctaattatgt gagtttatag     5280

ataatgttct tgttcattca gaggactgta agcacttctg tacagaagct tgtttagaaa     5340

cagccctcat ggccgggcgt ggtggctcac gctgtaatcc caacactttg ggaggccgag     5400

gcgggtggat cacctgaggt caagagttca agaccagcct ggccaacatg gtgaaacccc     5460

aactctatta aaagtacaaa aaattagctg ggcatggtgg tgaacgcctg taaccccagc     5520

tacttgggag gctgaggcag gagaatcgct tgaacccagg aggtggaagt ttcagtgagc     5580

tgagatcacg ccattgcact ctagcctggg caacaaaaga gaaactccat ctcaaaaaaa     5640

aaaacaagga aaaaaagaaa cagccctcat gacacttaga aagtagaata gctggctgtt     5700

atctgaacat tgaattgtaa ggcttatcag gtggactttg cattccatca gcagacaatt     5760

tttttttttt tttttttttg agatggagtc tcattctgtc tcccaggctg gagggcagtg     5820

gtgcgatctc ggctcactgc aagctccacc tcctgggttc atgccattct cctgcctcag     5880

cctcccaagt agctgggacc acaggcaccc gccaccatgc ccagttaatt ttttgtattt     5940

ttagtagaga cggggtttca ccatgttagc caagatggtc tcgatctcct gacctcgtga     6000

tccgcccacc tcggcctccc aaagtgctgg gattacaggc atgagccacc gcgcctagcc     6060

tacaaatgtt ttgtaatagc tcttgaggcc catcttggag ttctcctttt gctaaaacca     6120

ctgaactctc taggaggaaa aaggaacttg gttcttgaca tatgtgtgca tgtatttcca     6180

tataaccttt aggaagctat tgcaatggta ctataaacta gaattttaga agatagaagg     6240

aaaatattct ggagatcatt gaagagaaat ggagtccaac actagttaaa gatgatgaag     6300

acagattttt ttttttgacg gagtctcgct ctgtcgccca ggctggagtg cagtggcaca     6360

atctcagctc actgcaaccc tccacctctt gggttcaagt gattctcctg cctcagcctc     6420

ccaagtagct gggactacag gcgcacacca ccacgcccgg ctaatttttg tatttttagt     6480

agagacaagg tttcaccata ttcgccaggc tggtctcgaa ctcctgacct tgtaatccgc     6540

ccaccttggc ctcccaaagt gctgggatta caggcatgag ccaccacgcc cggccgatga     6600

agacagattt tattcagtac taccacagta gaggaaagag ccaagttcaa ttccaaatac     6660

aacaaagaca ggtggagatt tatagccaat gagcagattg agggggtcag tggatggaat     6720

atttaagaag acatcaaggg tagggagctt cttgctaaag cttcatgtac ttaaacaaga     6780

agggtggggg atgagggaaa ttgatcagat atcaatggtg gcagtattga cttagcagga     6840

ttcttgctaa gaggtcttgc taggacagac ataggaagcc aaggtggagg tctagtcgaa     6900

aagaaggctc atcagagaag tctaactaaa gtttggtcaa gaagagtctt tgtcaaggta     6960

aatctatcat ttccctcaaa aggtaatttt caggatccca tcaggaagat tagcatggct     7020

gctagctttc tcctcagttc tgggctatag ctcacatgcc tagtttgaac tagctcagca     7080

gaactggggg atttattctt tgtcttccaa caaactcatc tggatgattt tgggggtttg     7140

tggggaaaag cccccaatac ctggtgaagt aaccttgtct cttcccccag cctggaatgg     7200

ttctctcttt ctgctacctc acgattgtgc ttctacaatg gtgactcttt tcctccctct     7260

catttcaggt tcacagcaaa ggactgaagc tagggattta tgcagatgtt ggaaataaaa     7320

cctgcgcagg cttccctggg agttttggat actacgacat tgatgcccag acctttgctg     7380

actggggagt agatctgcta aaatttgatg gttgttactg tgacagtttg gaaaatttgg     7440

cagatggtaa tgtttcattc cagagattta gccacaaagg aaagaacttt gaggccatgg     7500

tagctgagcc aaagaaccaa tcttcagaat tttaaatacc ctgtcacaat actggaaata     7560

attattctcc atgtgccaga gctcccatct cttctctttc agttcattaa ttaattaatt     7620

aattcatgta aaatccatgc atacctaacc atagctaata ttgtgcactt ataattcaag     7680

agggctctaa gagttaatta gtaattgtaa ctctctataa catcatttag gggagtccag     7740

gttgtcaatc ggtcacagag aaagaagcat cttcattcct gcctttcctc aatatacaca     7800

ccatctctgc actacttcct cagaacaatc ccagcagtct gggaggtact ttacacaatt     7860

taagcacaga gcaactgcct gtccctgctg ctagtttaaa catgaacctt ccaggtagcc     7920

tcttcttaaa atatacagcc ccagctgggc atgatggctc atgcctgtaa tcctagcact     7980

ttgggaggct gaggcgggtg gattacttga ggtcaggagt tcgagaccac cctggccaac     8040

atggtgaaac cccatctcta gtaaaaatac aaaaattagc tgactttggt ggcacatgcc     8100

tgtaatccca gctacttggg aagctgagac agaagagtca cttgaacctg ggaaacagag     8160

gttgcagtga gccaagatcg caccactgca ctccaccctg gatgacagac tgaaccccat     8220

ctcaaaaaat taaaataaaa taaaataaaa taactatata tatagcccca gctggaaatt     8280

catttctttc ccttatttta cccattgttt tctcatacag gttataagca catgtccttg     8340

gccctgaata ggactggcag aagcattgtg tactcctgtg agtggcctct ttatatgtgg     8400

ccctttcaaa aggtgagata gtgagcccag aatccaatag aactgtactg atagatagaa     8460

cttgacaaca aaggaaacca aggtctcctt caaagtccaa cgttacttac tatcatccta     8520

ccatctctcc caggttccaa ccacttctca ccatccccac tgctgtaatt atagcctaag     8580

ctaccatcac ctggaaagtc atccttgtgt cttccccttt atttcaccat tcatgtcctg     8640

tctatcaaca gtccttccac cagtatctct aaaatatctc ctgaatcagc ccacttcctt     8700

ccatcttcac tacatgcacc ctggccttcc aagctactat cggctctcaa ccagactgct     8760

gggaccacct gatctctctg cttccactct gtctcaaccc ccatctattt tccaagcagc     8820

actagagtta tcatattaaa atgtaaatat cagttttttt tttaaagaaa aaaaccctga     8880

gacttaacag agttataaaa aatataaatg tcatcatcag ttccctgctt aaaaccctta     8940

actcgcttcc aattgcactt ggaatgaaac caaactgcac tgatccagcc cttgcctgcc     9000

tccccaaagt ccaaggggtc atggctcttt ccctggctac actggttttc tttctgtccc     9060

tcaacactgc aagcctattg ctgccccagg gcctttacac ttgctttttt tctgcctaga     9120

acagttcttc cccaaagatt tttaaagggc cgggctcctt aacattgaag tcgcagacca     9180

aacgccacat atgcagacag ttcttctcta actactttaa aatagccctc tgtccattca     9240

ttcttcatca cattaacctg tttaattttc ttctcagagc tccacactat ttggaagtat     9300

ttgttgactt gttaccatgt ctccccacta gagtgtaagt ttcatgaggg cagggacctt     9360

gtctgacttt gactgtatct ctcgcatatg gttaagtgtt aaatagttat ttatggaatg     9420

aatccctatt attccctcat tatctctgca aaatagtctt ttttctcaac atcttaaacc     9480

tgatatccca cctgcctatc tacaaacttt ttttttgcga cagagtctca ctgtcaccca     9540

ggctagagtg cagtggcgcc atctcggctc actgcaacct ccgcctcccg ggtttaagcg     9600

attctcttgc ctcagcctcc cagtagctgg gattataggc gtgcgctacc acatctggct     9660

aatttttgta tttttagtag agatggtttc accatgttgg ccaggcttgt ctcgaactcc     9720

tgacctcaga tgatccacct gcctcggcct cccaaagtgc tgggattaca ggcatgagcc     9780

accgtgccca gcctctacaa actttttatt ccattaacaa actatatgct gggatttaag     9840

ttttcttaat acttgatgga gtcctatgta attttcgagc ttttaatttt actaagacca     9900

ttttagttct gattatagaa gtaaattaac tttaagggat ttcaagttat atggcctact     9960

tctgaagcaa acttcttaca gtgaaaattc attataaggg tttagacctc cttatggaga    10020

cgttcaatct gtaaactcaa gagaaggcta caagtgcctc ctttaaactg ttttcatctc    10080

acaaggatgt tagtagaaag taaacagaag agtcatatct gttttcacag cccaattata    10140

cagaaatccg acagtactgc aatcactggc gaaattttgc tgacattgat gattcctgga    10200

aaagtataaa gagtatcttg gactggacat cttttaacca ggagagaatt gttgatgttg    10260

ctggaccagg gggttggaat gacccagata tggtaaaaac ttgagccctc cttgttcaag    10320

accctgcggt aggcttgttt cctattttga cattcaaggt aaatacaggt aaagttcctg    10380

ggaggaggct ttatgtgaga gtacttagag caggatgctg tggaaagtgg tttctccata    10440

tgggtcatct aggtaacttt aagaatgttt cctcctctct tgtttgaatt atttcattct    10500

ttttctcagt tagtgattgg caactttggc ctcagctgga atcagcaagt aactcagatg    10560

gccctctggg ctatcatggc tgctccttta ttcatgtcta atgacctccg acacatcagc    10620

cctcaagcca aagctctcct tcaggataag gacgtaattg ccatcaatca ggaccccttg    10680

ggcaagcaag ggtaccagct tagacaggta aataagagta tatattttaa gatggcttta    10740

tatacccaat accaactttg tcttgggcct aaatctattt ttttcccttg ctcttgatgt    10800

tactatcagt aataaagctt cttgctagaa acattacttt atttccaaaa taatgctaca    10860

ggatcatttt aatttttcct acaagtgctt gatagttctg acattaagaa tgaatgccaa    10920

actaacaggg ccacttatca ctagttgcta agcaaccaca ctttcttggt ttttcaggga    10980

gacaactttg aagtgtggga acgacctctc tcaggcttag cctgggctgt agctatgata    11040

aaccggcagg agattggtgg acctcgctct tataccatcg cagttgcttc cctgggtaaa    11100

ggagtggcct gtaatcctgc ctgcttcatc acacagctcc tccctgtgaa aaggaagcta    11160

gggttctatg aatggacttc aaggttaaga agtcacataa atcccacagg cactgttttg    11220

cttcagctag aaaatacaat gcagatgtca ttaaaagact tactttaaaa tgtttatttt    11280

attgccaact actacttcct gtccaccttt ttctccattc actttaaaag ctcaaggcta    11340

ggtggctcat gcctgtaatc ccagcacttt gggaggctga ggcgggcaga tcacctgagg    11400

tcgggacttt gagacccgcc tggacaacat ggtgaaaccc catttctaat aaaaatataa    11460

aaattagcca ggtgtggtgg cgcacctgtg gtcccagcta ctctgggggc tgaggcatga    11520

gaatcgcttg aacccgggag tggaggttgc attgagctga gatcatgcca cctcactcca    11580

gcctgggcaa caaagattcc atctcaaaaa aaaaaaaaaa gccaggcaca gtggctcatg    11640

cctggaatcc cagcactttt ggaagctgag gcaggcagat cacttgaggt taggatttca    11700

agaccagcct ggctaacata gtaaagccct gtctctacta aaaatacaaa aattagccag    11760

gtatggtggc gagcttctgt agccccagct actcaggaga ctgaggcagg agaatcactt    11820

gaacccggga agtggggggg tgcagtgacc caagatcacg ccactgcatt ccagcctggg    11880

caacagagca agactccatc tcaaaaaaaa aagttctatt tccttgaata aaattttccg    11940

aagtttaaac tttaggaata aaactattaa acccgtattt actcatccag atacccaccc    12000

cccttgttga gattctctcc caattatcaa aatgtgtagc atatttaact accaagagct    12060

aaacatcatt aagactgaaa tgtattaaga aggatgtata ggccaggcac ggtgtctcac    12120

gcctgtaatc ccaacacttt gggaggccaa gtcgggcgga tcacgaggtc aggagatgga    12180

gaccatcctg gccaacatgg tgaaaccccc tctctactaa aaatacaaaa attagccagg    12240

caggtggcag gcacctgtaa tcccagctac tccagaggct gaggcaggac aatcacttga    12300

acctgggagg cagaggctgc agtgagctga ggttgtacca attgcactcc agcctaggta    12360

acgagcaaca ctccatctca aaaaaagaaa aaaaaaaaga tgtataattt ggaactgtta    12420

agaggcattt taaaga                                                    12436


<210>  2
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  3
<211>  1290
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcagctga ggaatcccga gctccacctg ggctgtgctc tggctctgcg gttcctggcc       60

ctcgtgtcct gggacatccc tggcgctagg gccctcgata acggactggc ccggaccccc      120

acaatgggat ggctccactg ggaaaggttc atgtgcaatc tggactgtca ggaggaaccc      180

gactcctgca tcagcgaaaa gctcttcatg gagatggccg agctgatggt gagcgagggc      240

tggaaggacg ccggctacga gtatctgtgc atcgatgact gctggatggc ccctcaaagg      300

gactccgaag gcaggctgca ggctgatccc caaaggtttc cccacggaat ccggcagctc      360

gccaactacg tgcattccaa gggcctcaag ctcggcatct acgccgacgt gggcaacaaa      420

acatgcgccg gattccccgg cagcttcggc tactacgaca tcgacgccca gacattcgct      480

gattggggag tggacctgct gaagttcgac ggctgttact gcgattccct ggaaaacctg      540

gccgacggct acaaacacat gtccctcgcc ctgaaccgga caggcaggtc catcgtgtac      600

agctgcgagt ggcccctgta catgtggcct ttccagaagc ccaactacac agagatcagg      660

cagtactgca accactggag gaacttcgct gacatcgacg actcctggaa gagcatcaag      720

agcatcctgg actggaccag cttcaaccag gagaggatcg tggacgtggc tggacccgga      780

ggctggaacg accccgatat gctggtgatt ggcaacttcg gactgagctg gaaccagcag      840

gtgacccaga tggccctgtg ggccattatg gccgctcccc tgttcatgtc caacgacctg      900

aggcacatca gcccccaggc caaggctctg ctgcaggaca aggatgtgat cgccatcaac      960

caggaccccc tgggcaagca gggctaccag ctgaggcaag gagataactt cgaggtgtgg     1020

gagaggcccc tgtccggact ggcttgggcc gtggccatga tcaatcggca ggagatcggc     1080

ggaccccggt cctacaccat tgctgtggcc agcctgggaa aaggagtcgc ctgcaacccc     1140

gcctgcttca ttacccagct gctccccgtg aagcggaagc tgggcttcta tgagtggacc     1200

agcaggctga ggtcccatat caatcctacc ggcaccgtcc tcctccagct cgagaatacc     1260

atgcagatga gcctcaagga tctgctgtga                                      1290


