                         SEQUENCE LISTING

<110>  Roche Innovation Center Copenhagen A/S
 
<120>  MICRORNA-134 BIOMARKER

<130>  P34983-WO

<150>  EP18190523.3
<151>  2018-08-23

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  homo sapiens

<400>  1
ugugacuggu ugaccagagg gg                                                22


<210>  2
<211>  73
<212>  RNA
<213>  Homo sapiens

<400>  2
cagggugugu gacugguuga ccagaggggc augcacugug uucacccugu gggccaccua       60

gucaccaacc cuc                                                          73


<210>  3
<211>  12178
<212>  DNA
<213>  Homo sapiens

<400>  3
ggcccacaga ggagcacagc tgtgtttggc tgcagggcca agagcgctgt caagaagacc       60

cacacgcccc cctccagcag ctgaattcct gcagctcagc agccgccgcc agagcaggac      120

gaaccgccaa tcgcaaggca cctctgagaa cttcaggtag gagaaaagca aactccctcc      180

aacctcttac ttcgggctta aggcagagaa ctcgcctccc cagaatctcc tccctccatg      240

atcccccgct attcctctat tttcttttcc tcggacctgc agccttgggt cgaccctgcc      300

ctaggggtga ctgcaggaga gcagggagga tggtcaggcg tcaccaacaa ccccatcacc      360

cagtaacaag aaccttgact ctctcagtcc ctctgcatca agacacttac ccatttccca      420

cctcatgcct gctaacttga atgaaacaat cgctgggaaa gcattaagag aattaaggct      480

gggcactgtg gctcatgcct gtaatcccag cactttgtga ggctgaggca ggcagataac      540

ttgagcccag gagtttgaga ccagcctggg caacatggca aaaccctgct ctcccaaaaa      600

aatacaaaaa ttagctgggc gtgctggtgt gcctgtattc ccagctactt gggaggctga      660

ggtgggagga ttgcttcagc tggggaggcg gaggctgcag ggagccaaga ctgagccatt      720

gcacccagcc tgggtgacag agcaagaccc tgtctctaaa aatgaatgaa aggaaggaag      780

aaagagagag aaagagagag aggaaagaag gaaggaagta aagaagaaag aaagaaagaa      840

agaggaaaga ggaagaaaga aagaaaagaa agaaaagaaa agaaagcaaa tttaaagctt      900

atgcaaatca aagatgttgt gataattgat aattgagtct gggctaaatt ccccctgggc      960

tgcaaaggca gagagtggta atgacttctc acctgctttt cttctaaggc ttttttacgg     1020

gacacagagg gaagggagat ggactggatt ccaagattcc cacagggcaa gatgggcgaa     1080

gactccctgc cactgcccgg ggataagtca gtctgagtga gacggagtgg gatgggctta     1140

gaacctgaac atgtcatggt ctcttcctgc accttgccct agtgttcact taccacctgc     1200

ttgcaggaaa caagaagagc agggcccaca gctggccagc tcccctcccc tcccgcctgt     1260

cttccagaac gattccttca ccagccctct ttccattgct ctaggatgca gatgtctcca     1320

gccctcacct gcctagtcct gggcctggcc cttgtctttg gtgaagggtc tgctgtgcac     1380

catcccccat cctacgtggc ccacctggcc tcagacttcg gggtgagggt gtttcagcag     1440

gtggcgcagg cctccaagga ccgcaacgtg gttttctcac cctatggggt ggcctcggtg     1500

ttggccatgc tccagctgac aacaggagga gaaacccagc agcagattca agcagctatg     1560

ggattcaaga ttgatggtga gccacgggac accaggggag gtgggtggca tgcagaacag     1620

acctaccaga agccaaggaa aggctggctc tggcttagcc gagccaagcc ccatacagct     1680

gtgctgcagg ggccacccca tcttcttccc actacactcc aagtcactgg acccttgaat     1740

ctccaagggt gtctgaccag tagatttacc gcttattcac caccgtgtga tcttaacctc     1800

gttaagtttg cccatctaca aaatgaggat tatttgctgt cctaaagaat tcatgagccg     1860

ggcgcggtgg ctcaaacgcc tgtaatccca gcactttggg aggccaaggc gggcggatca     1920

tgaggtcagg agatcaagac catcctggct aacacagtga aactccatct ctactaaaaa     1980

tacaaaaaaa attagccagg cgtggtggca ggcgcctgta gtcccagcta ctcgggaggc     2040

tgaggcagga gaatggcatg aacccaggag gcagagcttg cagtgagctg agatcgtgcc     2100

actgcactcc agcctgggcg acagagagag actccgtctc aaaaaaaaaa aataaaagaa     2160

ttcatggaat tacacttgtg aaatacttag catagccatc actataggaa aaaaatctaa     2220

ggccaggcac agtgcctcat gcctgtaatc tcagcacttt cggagtttga ggcaggagga     2280

tcacccaagg ctaggagttc aaggccagcc tgggcaatac ggtgaaaccc cgtctctaat     2340

aaaaatataa aaattagtct gatgaggtgg tgcacctgta atcccagcta ctcaggaagc     2400

tgagacacaa gaatcacttt aacccgggag gtggaggtgg cagtgagctg agatcacacc     2460

attgcactcc agcctgggtg acagagtgag acctgtcaaa aaaaagaaaa gaaagagaga     2520

gagagagaga agagagagaa agaaagaaga agaaagaaag aaagagagag agagaaagaa     2580

agaaagaaac aaagaaacaa agaaagaaag gaaaagaaaa aaaaaactaa ggccaggcaa     2640

ggtggcttat gactgtaatt tcagcacttt ggaagattga ggcaggagga tcacttgagg     2700

ccagaagttc gagacaagac tgagcaacag ggagacccct gcctctacaa aaaaatttac     2760

aaattagcca gatgtggtga cacatacctg tagtcccaac tactcaggag gctgaggtgg     2820

gaggatggct tgagcccagg agctggaggc tgcagtgagc tatgattgta ccactgcact     2880

tcagcctggg caacaaaggg aagccctgtc tgaaaaaaaa aaaaaaagaa aaagaagaag     2940

aaagaaaata tttagggttc atccaggagg cagaggttgc agtaagctga catcgcgcca     3000

ttgcactcca gcctgggaga caagagcaaa actccaactc aaaaaaaaaa aaaaaaaaaa     3060

aacaggaaga aaatatttag ggttcataat ttaagaacag agaaaaatat tctagcccaa     3120

agaaagggtt gggatctgag acttttgaag aaaggaagga gatacagaaa agagatttca     3180

tcctggaatg aaatctccct ccagagagcc ctgggaaagc acggtagccc ccatccatca     3240

gagtggagcc ccttgtgggg gaagtgggct cggctgggaa ccctcaattc agcataagcc     3300

tcacatgtcc tctcctctct gtcccggtgc agacaagggc atggcccccg ccctccggca     3360

tctgtacaag gagctcatgg ggccatggaa caaggatgag atcagcacca cagacgcgat     3420

cttcgtccag cgggatctga agctggtcca gggcttcatg ccccacttct tcaggctgtt     3480

ccggagcacg gtcaagcaag tggacttttc agaggtggag agagccagat tcatcatcaa     3540

tgactgggtg aagacacaca caaaaggtga gcaggcaggg aaaggaaacc catttcctgg     3600

gcctcaagag aaagggaatt tggaaataaa tccacatatc ccagttgggt gcagtagttc     3660

acacctgtaa tcccagccca acactttggg aggtctaggc gagaggaagg cttgaggcct     3720

ggagtttgag accagcctgg ccaacataac aagacctcat ctcttcaaaa aatttaaaaa     3780

ccagccgggc atggtggtgc acacctgtag tcccagctac ttgggaggct gaggtgggag     3840

gatcacttga gtccagcagt tcaaggctgc agtgagctat gtttgcacca ccacactcca     3900

gcctgggtca cagaacaaga cctcatctct aaaaaacaaa caaaaaccaa atccacatat     3960

cctaaaaaat gctccttttc agcattctct tctctatgga caaagggctg gatgctttaa     4020

gaaccaaatc ttaggctggg cacggtggct cacgcctcta atcctagcac tttgagaggc     4080

caaggcgggc agattgcctg agcacaggag ttcgagacca gcctggccaa catggtgaaa     4140

ccctgtctct gtcaaaaata caaaaaatta gccaggtgtg ttggcgcatg cctataatcc     4200

cagctgctcg ggaggatgag gttcaaagaa tcacttgaac ccgggaggca gaggctgcag     4260

tgagctgaga tcatgccact gcactccagc ctgggtgaca gagcaagact ttgtctccaa     4320

aaaaaggaac tagacgggtt catttaaacc cctgactgca gccctttgac atacatccaa     4380

ttgaggactg gggactccgg gaaacatcta aaaggcttaa aaactttgtc taacttcagc     4440

cgggcatggt ggctcacacc tgtaatccca gcactttggg aggctaaggc aggtggatca     4500

aaaggtcagg agtttgagac gagcctgacc aacatggtga aaccccgtct ctactaaaaa     4560

tacaaaaatt agccaggcat ggtggcaggc gcctgtaatc ccagctattc gggaggctga     4620

ggcaggagaa ttgcttgaac cccggagaca gaggttgcag cgagccgaga tcgcgccact     4680

gcactccagc ctggcaatag agtgagactc catctcaaaa caacaacaac aacaacaaca     4740

aaatcgtcta acttcctgat cttcctgatc attgattttc ccataggtat gatcagcaac     4800

ttgcttggga aaggagccgt ggaccagctg acacggctgg tgctggtgaa tgccctctac     4860

ttcaacggcc agtggaagac tcccttcccc gactccagca cccaccgccg cctcttccac     4920

aaatcagacg gcagcactgt ctctgtgccc atgatggctc agaccaacaa gttcaactat     4980

agtaagtcca agagcccctt ccccacagcc cacagcaact gcatctcatt cctggggtct     5040

cccaaggaat acccaaaatg tcaccctctg agggaggaag accacaggga atgctcccct     5100

ttaagggagg agagacccta gaatatactc cagctttgac aaagatttcc caagcaggag     5160

acatcaggat aatgggaaca gaagacagga ggtttatccc atgaaggatg aagaagctga     5220

aatccagaga ttccctcagg gccacatttg tccacctgac tccagggtct catcttcgtg     5280

tgttgctagt gtgattacct ggggatgaga aatcctgctg ggggagttga ggttaagagg     5340

atgaggactc caggtgctgt ggctcacgcc tgtaatccca gcactttggg aggccaaggc     5400

aggtggatca ggagtttgag gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc     5460

ctgtctctac taaaaatgca aaaattagcc aggtgtggtg gcaggcgcct gtaatcccag     5520

ctactcggga ggctgaggca ggagaatcac ttgagcccgg gaggtggagg ttgcagtgag     5580

ccgaacgaaa ttgagccact tcaccccagc ctgggcaaaa gagtgaaatt ccattcaaaa     5640

aaaaaaaaaa aaaaaaaagg atgaggactg ggatgaactg gtggctgggt gtggggaaaa     5700

tggaagtgaa ggaaggccaa aagagacaga gaaggcctgg cgcggcgact cacgcctata     5760

atcccagcac tttgggaggc tgagaagggg gattgcttga ggccagaagt tgaataccag     5820

tctgggcagc atagcaagac cctgcctcta caaaaaaaaa atttttttta attagccagg     5880

cttggtgaca tgcatctgta gtctactcaa gaagctgagg tgaggccagg cacggtggct     5940

cacgcctgta ttcccagcac tttgggaggt caaggcgggt ggatgacctg aggtcaggag     6000

ttcaagacca gcctggccaa catggtgaaa ccccatctgt ataaaaatac aaaaattagc     6060

tgggcatgat agcaggtgcc tgtaattcca gctactcagg aggctgaggt gggagaatct     6120

attgaacccg ggagggggag gttgcagtga gccgagatca tgccattgca ctccagcctg     6180

ggcgacagag tgagactcct tctcaaaaca aacaaacaaa caaacaaaca aaatacagaa     6240

gctgaggcgg gaggaacatt tgaaccggat tcggaggctg cagtgagcta tgattgcacc     6300

actgcgctcc agtctgtgtg acagtgagac cctgtctctt acacacacac acacacacac     6360

acacatgcac acacacagag agagagaaat tagaagatac tgaattggca gaagagaagg     6420

gaaatagaaa ttaaaatact gaatagggga gcagtgaaca ggggataccc aaaagccaag     6480

agcgagagag agcctggctt ccagaaatag tggagaagcc aggagaacta ggtgaaaacc     6540

cagtgctggg ttgccatcag cgagagctgg agccatttcc aacgaaccat cttgtcgtct     6600

tcacagctga gttcaccacg cccgatggcc attactacga catcctggaa ctgccctacc     6660

acggggacac cctcagcatg ttcattgctg ccccttatga aaaagaggtg cctctctctg     6720

ccctcaccaa cattctgagt gcccagctca tcagccactg gaaaggcaac atgaccaggc     6780

tgccccgcct cctggttctg cccaagtaag ccaccccgct atctccccga cctaccaacc     6840

cctctctcct ggctccctaa agtcaccgcc cccaggttga atttcccaga tctgtgatgc     6900

ttgcaggaca tgcatgtgtg ggaggctgat gggaaactgt ggcctgggtt tgattatgag     6960

tcttgcaatc atccctcccc ctgtttctgc tggagggcag gggacagctc ttcctgacca     7020

cacccccaca ttgactatcc ccagaatacc cagcaaaagc ccccaaaagg agagtcagag     7080

aaatgaggga ggtgggggcc caatcagtcc acatctactt agggtcgccc catcagcact     7140

tccatcccca accctttcaa gtcaacatcc aaacaaaaga aatcacttcc aaggacggag     7200

cagctcaaag cgcagcttct agctggggtt ccaagaaagc agatttttcg aaatccttct     7260

gcagaaggaa gcaaagagat tttttgaaat ctttctgcag aaggagaagg ctggagctgg     7320

ggaactccag aattataggg aagcctccca ccacgctcat cccaaatttc cggatgctat     7380

aatgccaggc ttggggaaag aggagaattt agttggttag ctggtgcgtg ctctcacttg     7440

catcctctct cttcctcttt tttttttttc tcctctctct ctggctcata aaaatggagg     7500

taattagttg tgccctggtg agaagcagag agtgcacaaa ggccccctgc ttgagtcctc     7560

ttcagggtta gctctcagaa acacaatctg cagaacagat ttttgttcca acatccttgc     7620

aggagaattt gcccttagct tcccccaccc cagccaggct gaataaaatt atgctgaaac     7680

tactgtctta tttgaggaaa gtaattagtc ataggtggga gggggtgggg agattgcaga     7740

agaatgttca tgaatattag gattttcagc tctaaggggg gactttgtaa acagctttag     7800

aagaagaacc aggccggctg ggtgtggtgg ctcatgcctg taatctcagc atttggggag     7860

gccaaggcgg gcggatcact tgaggtcagg agtttgagac cagcctggcc aacatggtga     7920

aaccctgtct ctattaaaaa tacaaaaatt agccagccgt ggtagcgagc gcctatgatc     7980

ccagctactc cggaggctga ggccagagaa tcacatgaac ctgggaggtg gaggctgcag     8040

tgagccgaga tcacgccact gcactccagc ctgggggaca gagcaagaat ctgtttcaaa     8100

aaaaaaaaaa gaaaaatagg aaggaaggaa ggaaaggaaa ggaaagaaga gagagagaaa     8160

gaaagagaga gagagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga     8220

aagaaagaaa gaaagaaaaa gaaaggaaag aaagaacgaa cgaaccaggc ctccctctcc     8280

aaccttcacc tccgtcccta ttctggccac ttgattcggg ggacacctgg taggggatgg     8340

ggaaaggtgg gagctgccag ccagagggga ccccggcttg agcagcctct tgctgctatc     8400

tgcaggttct ccctggagac tgaagtcgac ctcaggaagc ccctagagaa cctgggaatg     8460

accgacatgt tcagacagtt tcaggctgac ttcacgagtc tttcaggtaa gaagactttc     8520

ctttgcattt tctcacccca gtggactgcg ggggccccta agaggaaaaa ggaacctctc     8580

cttgagagcg gcagctgatc taatcctgta tccacatctg tttcagacca agagcctctc     8640

cacgtcgcgc aggcgctgca gaaagtgaag atcgaggtga acgagagtgg cacggtggcc     8700

tcctcatcca caggtgagtc tggctcaggt gaggctccac gggtgtcgcc tccatcgccc     8760

ttcaggataa ctggtcccca gacccggaaa ggaccccgca gccctctcgg cacagagcag     8820

ctctgtctgt gctcagccat cacccactcc ccacctgttt ctcagcctgg aaaacgggct     8880

tgggaccatg gaaccctgtt tcctcgcctg atggctccta agttccctga ctgtgaaaag     8940

gcctcctaaa gaaaaaccca agttgttccc acagtgggaa gtaaacttaa gaaacatgct     9000

tatcaggctg ggcatggtgg ctcccacctg taatcccagc gctttggggg accaaggcag     9060

gtggatcact tgaggtcagg aattcgagac cagcctgggc aacatggcaa aaccctatct     9120

ctactaaaaa tacaaaaatt aggcaggcgt ggtggcatgt gcctgtagtc ccagctactt     9180

gggaggctga ggcaggagaa tcacttgaat ccaggaggca gaggttgcag tgagccgaga     9240

tcacgctgct gcactccagc ctgggcaata gagcatgact ctgaagaaaa gaaagaaaga     9300

aagagagaga gagagaaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag     9360

aaagaaagaa agaaagagaa agaaagagaa gaaaagaaaa gaaagagctt atcaataagc     9420

ccttaaagga tttagataaa tgtgtgtaag ggaagagctg atccattgct accaagctcc     9480

tggaggaaac caggtctcag aggatgtccc taaactttta aggttcatat tcaggaaaac     9540

aaacaacttc cagctgggct tagtggctca cacctgtaat cccagcactt tgggaggccg     9600

aggcaggagg atcgcttgag cccaggaatt tgagaccagc ctgggcaata taatgagact     9660

gtgtctctac aaaaattaga aaaaaattag ccaggcatgg tggcatgcac ctgtagcccc     9720

agttacttgg gagactgagg tgggaggatc acttgagccc atgagttcaa ggctgcagtg     9780

agccatgaag gtgccactgc actcccacct gggcgacaga gggagaccct gtctctaaga     9840

aaaacggcgg gggtgggggt ggtgccagtg ccagcatccc tctgttctaa gacattgtcc     9900

cttctcttgc agctgtcata gtctcagccc gcatggcccc cgaggagatc atcatggaca     9960

gacccttcct ctttgtggtc cggcacaacc ccacaggtga gcctggaacc catcacgttc    10020

cacatcctcc cacccattct ttctctcagg aactagtccc gacagatgca gacatccctc    10080

tatccctgag agggctctgg gcagggaacc cataacccta ccctgcttcc tgtcccaaga    10140

ggaggctacc ttctatcacc cacagacagt gccgggtccc cgctctgtga ctcaggcagc    10200

tgcgactcca gacagctcac tcatctgcct agatctcagt ccttccaccc acatccagcc    10260

tgatgagctg tcccactcct tctgcttctc aacccccatg gttcttccac cctcaggaac    10320

agtccttttc atgggccaag tgatggaacc ctgaccctgg ggaaagacgc cttcatctgg    10380

gacaaaactg gagatgcatc gggaaagaag aaactccgaa gaaaagaatt ttagtgttaa    10440

tgactctttc tgaaggaaga gaagacattt gccttttgtt aaaagatggt aaaccagatc    10500

tgtctccaag accttggcct ctccttggag gacctttagg tcaaactccc tagtctccac    10560

ctgagaccct gggagagaag tttgaagcac aactccctta aggtctccaa accagacggt    10620

gacgcctgcg ggaccatctg gggcacctgc ttccacccgt ctctctgccc actcgggtct    10680

gcagacctgg ttcccactga ggccctttgc aggatggaac tacggggctt acaggagctt    10740

ttgtgtgcct ggtagaaact atttctgttc cagtcacatt gccatcactc ttgtactgcc    10800

tgccaccgcg gaggaggctg gtgacaggcc aaaggccagt ggaagaaaca ccctttcatc    10860

tcagagtcca ctgtggcact ggccacccct ccccagtaca ggggtgctgc aggtggcaga    10920

gtgaatgtcc cccatcatgt ggcccaactc tcctggcctg gccatctccc tccccagaaa    10980

cagtgtgcat gggttatttt ggagtgtagg tgacttgttt actcattgaa gcagatttct    11040

gcttcctttt atttttatag gaatagagga agaaatgtca gatgcgtgcc cagctcttca    11100

ccccccaatc tcttggtggg gaggggtgta cctaaatatt tatcatatcc ttgcccttga    11160

gtgcttgtta gagagaaaga gaactactaa ggaaaataat attatttaaa ctcgctccta    11220

gtgtttcttt gtggtctgtg tcaccgtatc tcaggaagtc cagccacttg actggcacac    11280

acccctccgg acatccagcg tgacggagcc cacactgcca ccttgtggcc gcctgagacc    11340

ctcgcgcccc ccgcgcccct ctttttcccc ttgatggaaa ttgaccatac aatttcatcc    11400

tccttcaggg gatcaaaagg acggagtggg gggacagaga ctcagatgag gacagagtgg    11460

tttccaatgt gttcaataga tttaggagca gaaatgcaag gggctgcatg acctaccagg    11520

acagaacttt ccccaattac agggtgactc acagccgcat tggtgactca cttcaatgtg    11580

tcatttccgg ctgctgtgtg tgagcagtgg acacgtgagg ggggggtggg tgagagagac    11640

aggcagctcg gattcaacta ccttagataa tatttctgaa aacctaccag ccagagggta    11700

gggcacaaag atggatgtaa tgcactttgg gaggccaagg cgggaggatt gcttgagccc    11760

aggagttcaa gaccagcctg ggcaacatac caagaccccc gtctctttaa aaatatatat    11820

attttaaata tacttaaata tatatttcta atatctttaa atatatatat atattttaaa    11880

gaccaattta tgggagaatt gcacacagat gtgaaatgaa tgtaatctaa tagaagccta    11940

atcagcccac catgttctcc actgaaaaat cctctttctt tggggttttt ctttctttct    12000

tttttgattt tgcactggac ggtgacgtca gccatgtaca ggatccacag gggtggtgtc    12060

aaatgctatt gaaattgtgt tgaattgtat gctttttcac ttttgataaa taaacatgta    12120

aaaatgtttc aaaaaaataa taaaataaat aaatacgaag aatatgtcag gacagtca      12178


<210>  4
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide base sequence

<400>  4
cccctctggt caaccagtca ca                                                22


<210>  5
<211>  19
<212>  DNA
<213>  Artficial

<400>  5
cctctggtca accagtcac                                                    19


<210>  6
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide base sequence

<400>  6
tggtcaacca gtcac                                                        15


<210>  7
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  8
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide base sequence

<400>  8
tggtcaacca gtcac                                                        15


