                         SEQUENCE LISTING

<110>  NATIONAL HEALTH RESEARCH INSTITUTES
       TAN, Tse-Hua
 
<120>  AhR-ROR-gamma t COMPLEX AS A BIOMARKER AND THERAPEUTIC TARGET FOR
        AUTOIMMUNE DISEASE AND IL-17A-ASSOCIATED DISEASE

<130>  10008-052NPA

<150>  62719416
<151>  2018-08-17

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-tag

<400>  1

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  2
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PKC theta intron 1 and exon 2 deleted sequence

<400>  2
ggtggaacac taaaaataat atgtcttaga gccccataca tacagtgttt gtcttttgtc       60

atttttctag ggaacaacca tgtcaccgtt tc                                     92


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine GLK epitope 4 to 19

<400>  3

Gly Phe Asp Leu Ser Arg Arg Asn Pro Gln Glu Asp Phe Glu Leu Ile 
1               5                   10                  15      


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine GLK epitope 514 to 533

<400>  4

Glu Gln Arg Gly Thr Asn Leu Ser Arg Lys Glu Lys Lys Asp Val Pro 
1               5                   10                  15      


Lys Pro Ile 
            


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine ROR gamma t epitope

<400>  5

Phe Ser Thr Asp Val Glu Ser Pro Glu Gly Leu Ser Lys 
1               5                   10              


<210>  6
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  6

Phe Ser Thr Glu Thr Glu Ser Pro Val Gly Leu Ser Lys 
1               5                   10              


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human GLK shRNA

<400>  7
gtgccactta gaatgtttga aa                                                22


<210>  8
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AhR-binding site

<400>  8
atgtccatac atacatgata ctgaatcaca gc                                     32


<210>  9
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RORgamma t-binding site (-887)

<400>  9
ctcaaagaca taaaggcaac cgtgatctca tggagaggag ag                          42


<210>  10
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR gamma t-binding site (-120)

<400>  10
ggttctgtgc tgcaatcatt tgagg                                             25


<210>  11
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STAT3-binding site

<400>  11
agacagatgt tgcctgtcat aaaggggtgg tt                                     32


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR gamma t (-877 to -872) forward primer

<400>  12
ctgaagagct gggacctaat g                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR gamma t (-877 to -872) reverse primer

<400>  13
gactactaac aggaggagat g                                                 21


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR gamma t -120 to -115  forward primer

<400>  14
ggttctgtgc tgacctcatt tgag                                              24


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR gamma t (-120  to -115) reverse primer

<400>  15
cacagatgaa gctctccctg g                                                 21


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AhR forward primer

<400>  16
gagactcaca aaccattact atg                                               23


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AhR reverse primer

<400>  17
cacagatgaa gctctccctg g                                                 21


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STAT3 forward primer

<400>  18
gagactcaca aaccattact atg                                               23


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  STAT3 reverse primer

<400>  19
cacagatgaa gctctccctg g                                                 21


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRF4 forward primer

<400>  20
gggcaaggga tgctctctag                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRF4 reverse primer

<400>  21
ctgaagctgc tgcagagctg                                                   20


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KLF4 forward primer

<400>  22
gggtattatc ccaagggtat cc                                                22


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KLF4 reverse primer

<400>  23
atgcagcatg aggtggaccg at                                                22


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BATF forward primer

<400>  24
gaacttctgc ccttcccatc t                                                 21


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BATF reverse primer

<400>  25
cagcacagaa ccaccccttt                                                   20


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-17A forward primer

<400>  26
gagactcaca aaccattact atg                                               23


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-17A reverse primer

<400>  27
cacagatgaa gctctccctg g                                                 21


<210>  28
<211>  1657
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His 
1               5                   10                  15      


Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp 
            20                  25                  30          


Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu 
        35                  40                  45              


Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys 
65                  70                  75                  80  


Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr 
                85                  90                  95      


Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His 
            100                 105                 110         


Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu 
        115                 120                 125             


Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn 
    130                 135                 140                 


Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe 
145                 150                 155                 160 


Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp 
                165                 170                 175     


Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr 
            180                 185                 190         


Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn 
        195                 200                 205             


Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile 
    210                 215                 220                 


Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu 
225                 230                 235                 240 


Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser 
                245                 250                 255     


Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn 
            260                 265                 270         


Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu 
        275                 280                 285             


Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn 
    290                 295                 300                 


Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp 
305                 310                 315                 320 


Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg 
                325                 330                 335     


Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser 
            340                 345                 350         


Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys 
        355                 360                 365             


Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln 
    370                 375                 380                 


Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln 
385                 390                 395                 400 


Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala 
                405                 410                 415     


Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu 
            420                 425                 430         


Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro 
        435                 440                 445             


Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn 
    450                 455                 460                 


Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser 
465                 470                 475                 480 


Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg 
                485                 490                 495     


Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn 
            500                 505                 510         


Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val 
        515                 520                 525             


Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu 
    530                 535                 540                 


Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala 
545                 550                 555                 560 


Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala 
                565                 570                 575     


Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln 
            580                 585                 590         


Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly 
        595                 600                 605             


Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala 
    610                 615                 620                 


Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly 
625                 630                 635                 640 


Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val 
                645                 650                 655     


Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys 
            660                 665                 670         


Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His 
        675                 680                 685             


Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu 
    690                 695                 700                 


Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu 
705                 710                 715                 720 


Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr 
                725                 730                 735     


Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu 
            740                 745                 750         


Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg 
        755                 760                 765             


Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser 
    770                 775                 780                 


Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala 
785                 790                 795                 800 


Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala 
                805                 810                 815     


Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe 
            820                 825                 830         


Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala 
        835                 840                 845             


Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro 
    850                 855                 860                 


Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp 
865                 870                 875                 880 


Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val 
                885                 890                 895     


Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu 
            900                 905                 910         


Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln 
        915                 920                 925             


Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln 
    930                 935                 940                 


Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala 
945                 950                 955                 960 


Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe 
                965                 970                 975     


Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln 
            980                 985                 990         


Met Pro Gln Asn Lys Ser Thr Lys  Phe Met Asp Ser Val  Ile Phe Thr 
        995                 1000                 1005             


Leu Tyr  Asn Tyr Ala Ser Asn  Gln Arg Glu Glu Tyr  Leu Leu Leu 
    1010                 1015                 1020             


Arg Leu  Phe Lys Thr Ala Leu  Gln Glu Glu Ile Lys  Ser Lys Val 
    1025                 1030                 1035             


Asp Gln  Ile Gln Glu Ile Val  Thr Gly Asn Pro Thr  Val Ile Lys 
    1040                 1045                 1050             


Met Val  Val Ser Phe Asn Arg  Gly Ala Arg Gly Gln  Asn Ala Leu 
    1055                 1060                 1065             


Arg Gln  Ile Leu Ala Pro Val  Val Lys Glu Ile Met  Asp Asp Lys 
    1070                 1075                 1080             


Ser Leu  Asn Ile Lys Thr Asp  Pro Val Asp Ile Tyr  Lys Ser Trp 
    1085                 1090                 1095             


Val Asn  Gln Met Glu Ser Gln  Thr Gly Glu Ala Ser  Lys Leu Pro 
    1100                 1105                 1110             


Tyr Asp  Val Thr Pro Glu Gln  Ala Leu Ala His Glu  Glu Val Lys 
    1115                 1120                 1125             


Thr Arg  Leu Asp Ser Ser Ile  Arg Asn Met Arg Ala  Val Thr Asp 
    1130                 1135                 1140             


Lys Phe  Leu Ser Ala Ile Val  Ser Ser Val Asp Lys  Ile Pro Tyr 
    1145                 1150                 1155             


Gly Met  Arg Phe Ile Ala Lys  Val Leu Lys Asp Ser  Leu His Glu 
    1160                 1165                 1170             


Lys Phe  Pro Asp Ala Gly Glu  Asp Glu Leu Leu Lys  Ile Ile Gly 
    1175                 1180                 1185             


Asn Leu  Leu Tyr Tyr Arg Tyr  Met Asn Pro Ala Ile  Val Ala Pro 
    1190                 1195                 1200             


Asp Ala  Phe Asp Ile Ile Asp  Leu Ser Ala Gly Gly  Gln Leu Thr 
    1205                 1210                 1215             


Thr Asp  Gln Arg Arg Asn Leu  Gly Ser Ile Ala Lys  Met Leu Gln 
    1220                 1225                 1230             


His Ala  Ala Ser Asn Lys Met  Phe Leu Gly Asp Asn  Ala His Leu 
    1235                 1240                 1245             


Ser Ile  Ile Asn Glu Tyr Leu  Ser Gln Ser Tyr Gln  Lys Phe Arg 
    1250                 1255                 1260             


Arg Phe  Phe Gln Thr Ala Cys  Asp Val Pro Glu Leu  Gln Asp Lys 
    1265                 1270                 1275             


Phe Asn  Val Asp Glu Tyr Ser  Asp Leu Val Thr Leu  Thr Lys Pro 
    1280                 1285                 1290             


Val Ile  Tyr Ile Ser Ile Gly  Glu Ile Ile Asn Thr  His Thr Leu 
    1295                 1300                 1305             


Leu Leu  Asp His Gln Asp Ala  Ile Ala Pro Glu His  Asn Asp Pro 
    1310                 1315                 1320             


Ile His  Glu Leu Leu Asp Asp  Leu Gly Glu Val Pro  Thr Ile Glu 
    1325                 1330                 1335             


Ser Leu  Ile Gly Glu Ser Ser  Gly Asn Leu Asn Asp  Pro Asn Lys 
    1340                 1345                 1350             


Glu Ala  Leu Ala Lys Thr Glu  Val Ser Leu Thr Leu  Thr Asn Lys 
    1355                 1360                 1365             


Phe Asp  Val Pro Gly Asp Glu  Asn Ala Glu Met Asp  Ala Arg Thr 
    1370                 1375                 1380             


Ile Leu  Leu Asn Thr Lys Arg  Leu Ile Val Asp Val  Ile Arg Phe 
    1385                 1390                 1395             


Gln Pro  Gly Glu Thr Leu Thr  Glu Ile Leu Glu Thr  Pro Ala Thr 
    1400                 1405                 1410             


Ser Glu  Gln Glu Ala Glu His  Gln Arg Ala Met Gln  Arg Arg Ala 
    1415                 1420                 1425             


Ile Arg  Asp Ala Lys Thr Pro  Asp Lys Met Lys Lys  Ser Lys Ser 
    1430                 1435                 1440             


Val Lys  Glu Asp Ser Asn Leu  Thr Leu Gln Glu Lys  Lys Glu Lys 
    1445                 1450                 1455             


Ile Gln  Thr Gly Leu Lys Lys  Leu Thr Glu Leu Gly  Thr Val Asp 
    1460                 1465                 1470             


Pro Lys  Asn Lys Tyr Gln Glu  Leu Ile Asn Asp Ile  Ala Arg Asp 
    1475                 1480                 1485             


Ile Arg  Asn Gln Arg Arg Tyr  Arg Gln Arg Arg Lys  Ala Glu Leu 
    1490                 1495                 1500             


Val Lys  Leu Gln Gln Thr Tyr  Ala Ala Leu Asn Ser  Lys Ala Thr 
    1505                 1510                 1515             


Phe Tyr  Gly Glu Gln Val Asp  Tyr Tyr Lys Ser Tyr  Ile Lys Thr 
    1520                 1525                 1530             


Cys Leu  Asp Asn Leu Ala Ser  Lys Gly Lys Val Ser  Lys Lys Pro 
    1535                 1540                 1545             


Arg Glu  Met Lys Gly Lys Lys  Ser Lys Lys Ile Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Thr Ala  Ala Arg Leu His Glu  Lys Gly Val Leu Leu  Glu Ile Glu 
    1565                 1570                 1575             


Asp Leu  Gln Val Asn Gln Phe  Lys Asn Val Ile Phe  Glu Ile Ser 
    1580                 1585                 1590             


Pro Thr  Glu Glu Val Gly Asp  Phe Glu Val Lys Ala  Lys Phe Met 
    1595                 1600                 1605             


Gly Val  Gln Met Glu Thr Phe  Met Leu His Tyr Gln  Asp Leu Leu 
    1610                 1615                 1620             


Gln Leu  Gln Tyr Glu Gly Val  Ala Val Met Lys Leu  Phe Asp Arg 
    1625                 1630                 1635             


Ala Lys  Val Asn Val Asn Leu  Leu Ile Phe Leu Leu  Asn Lys Lys 
    1640                 1645                 1650             


Phe Tyr  Gly Lys 
    1655         


<210>  29
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Asn Ser Ser Ser Ala Asn Ile Thr Tyr Ala Ser Arg Lys Arg Arg 
1               5                   10                  15      


Lys Pro Val Gln Lys Thr Val Lys Pro Ile Pro Ala Glu Gly Ile Lys 
            20                  25                  30          


Ser Asn Pro Ser Lys Arg His Arg Asp Arg Leu Asn Thr Glu Leu Asp 
        35                  40                  45              


Arg Leu Ala Ser Leu Leu Pro Phe Pro Gln Asp Val Ile Asn Lys Leu 
    50                  55                  60                  


Asp Lys Leu Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Ala Lys 
65                  70                  75                  80  


Ser Phe Phe Asp Val Ala Leu Lys Ser Ser Pro Thr Glu Arg Asn Gly 
                85                  90                  95      


Gly Gln Asp Asn Cys Arg Ala Ala Asn Phe Arg Glu Gly Leu Asn Leu 
            100                 105                 110         


Gln Glu Gly Glu Phe Leu Leu Gln Ala Leu Asn Gly Phe Val Leu Val 
        115                 120                 125             


Val Thr Thr Asp Ala Leu Val Phe Tyr Ala Ser Ser Thr Ile Gln Asp 
    130                 135                 140                 


Tyr Leu Gly Phe Gln Gln Ser Asp Val Ile His Gln Ser Val Tyr Glu 
145                 150                 155                 160 


Leu Ile His Thr Glu Asp Arg Ala Glu Phe Gln Arg Gln Leu His Trp 
                165                 170                 175     


Ala Leu Asn Pro Ser Gln Cys Thr Glu Ser Gly Gln Gly Ile Glu Glu 
            180                 185                 190         


Ala Thr Gly Leu Pro Gln Thr Val Val Cys Tyr Asn Pro Asp Gln Ile 
        195                 200                 205             


Pro Pro Glu Asn Ser Pro Leu Met Glu Arg Cys Phe Ile Cys Arg Leu 
    210                 215                 220                 


Arg Cys Leu Leu Asp Asn Ser Ser Gly Phe Leu Ala Met Asn Phe Gln 
225                 230                 235                 240 


Gly Lys Leu Lys Tyr Leu His Gly Gln Lys Lys Lys Gly Lys Asp Gly 
                245                 250                 255     


Ser Ile Leu Pro Pro Gln Leu Ala Leu Phe Ala Ile Ala Thr Pro Leu 
            260                 265                 270         


Gln Pro Pro Ser Ile Leu Glu Ile Arg Thr Lys Asn Phe Ile Phe Arg 
        275                 280                 285             


Thr Lys His Lys Leu Asp Phe Thr Pro Ile Gly Cys Asp Ala Lys Gly 
    290                 295                 300                 


Arg Ile Val Leu Gly Tyr Thr Glu Ala Glu Leu Cys Thr Arg Gly Ser 
305                 310                 315                 320 


Gly Tyr Gln Phe Ile His Ala Ala Asp Met Leu Tyr Cys Ala Glu Ser 
                325                 330                 335     


His Ile Arg Met Ile Lys Thr Gly Glu Ser Gly Met Ile Val Phe Arg 
            340                 345                 350         


Leu Leu Thr Lys Asn Asn Arg Trp Thr Trp Val Gln Ser Asn Ala Arg 
        355                 360                 365             


Leu Leu Tyr Lys Asn Gly Arg Pro Asp Tyr Ile Ile Val Thr Gln Arg 
    370                 375                 380                 


Pro Leu Thr Asp Glu Glu Gly Thr Glu His Leu Arg Lys Arg Asn Thr 
385                 390                 395                 400 


Lys Leu Pro Phe Met Phe Thr Thr Gly Glu Ala Val Leu Tyr Glu Ala 
                405                 410                 415     


Thr Asn Pro Phe Pro Ala Ile Met Asp Pro Leu Pro Leu Arg Thr Lys 
            420                 425                 430         


Asn Gly Thr Ser Gly Lys Asp Ser Ala Thr Thr Ser Thr Leu Ser Lys 
        435                 440                 445             


Asp Ser Leu Asn Pro Ser Ser Leu Leu Ala Ala Met Met Gln Gln Asp 
    450                 455                 460                 


Glu Ser Ile Tyr Leu Tyr Pro Ala Ser Ser Thr Ser Ser Thr Ala Pro 
465                 470                 475                 480 


Phe Glu Asn Asn Phe Phe Asn Glu Ser Met Asn Glu Cys Arg Asn Trp 
                485                 490                 495     


Gln Asp Asn Thr Ala Pro Met Gly Asn Asp Thr Ile Leu Lys His Glu 
            500                 505                 510         


Gln Ile Asp Gln Pro Gln Asp Val Asn Ser Phe Ala Gly Gly His Pro 
        515                 520                 525             


Gly Leu Phe Gln Asp Ser Lys Asn Ser Asp Leu Tyr Ser Ile Met Lys 
    530                 535                 540                 


Asn Leu Gly Ile Asp Phe Glu Asp Ile Arg His Met Gln Asn Glu Lys 
545                 550                 555                 560 


Phe Phe Arg Asn Asp Phe Ser Gly Glu Val Asp Phe Arg Asp Ile Asp 
                565                 570                 575     


Leu Thr Asp Glu Ile Leu Thr Tyr Val Gln Asp Ser Leu Ser Lys Ser 
            580                 585                 590         


Pro Phe Ile Pro Ser Asp Tyr Gln Gln Gln Gln Ser Leu Ala Leu Asn 
        595                 600                 605             


Ser Ser Cys Met Val Gln Glu His Leu His Leu Glu Gln Gln Gln Gln 
    610                 615                 620                 


His His Gln Lys Gln Val Val Val Glu Pro Gln Gln Gln Leu Cys Gln 
625                 630                 635                 640 


Lys Met Lys His Met Gln Val Asn Gly Met Phe Glu Asn Trp Asn Ser 
                645                 650                 655     


Asn Gln Phe Val Pro Phe Asn Cys Pro Gln Gln Asp Pro Gln Gln Tyr 
            660                 665                 670         


Asn Val Phe Thr Asp Leu His Gly Ile Ser Gln Glu Phe Pro Tyr Lys 
        675                 680                 685             


Ser Glu Met Asp Ser Met Pro Tyr Thr Gln Asn Phe Ile Ser Cys Asn 
    690                 695                 700                 


Gln Pro Val Leu Pro Gln His Ser Lys Cys Thr Glu Leu Asp Tyr Pro 
705                 710                 715                 720 


Met Gly Ser Phe Glu Pro Ser Pro Tyr Pro Thr Thr Ser Ser Leu Glu 
                725                 730                 735     


Asp Phe Val Thr Cys Leu Gln Leu Pro Glu Asn Gln Lys His Gly Leu 
            740                 745                 750         


Asn Pro Gln Ser Ala Ile Ile Thr Pro Gln Thr Cys Tyr Ala Gly Ala 
        755                 760                 765             


Val Ser Met Tyr Gln Cys Gln Pro Glu Pro Gln His Thr His Val Gly 
    770                 775                 780                 


Gln Met Gln Tyr Asn Pro Val Leu Pro Gly Gln Gln Ala Phe Leu Asn 
785                 790                 795                 800 


Lys Phe Gln Asn Gly Val Leu Asn Glu Thr Tyr Pro Ala Glu Leu Asn 
                805                 810                 815     


Asn Ile Asn Asn Thr Gln Thr Thr Thr His Leu Gln Pro Leu His His 
            820                 825                 830         


Pro Ser Glu Ala Arg Pro Phe Pro Asp Leu Thr Ser Ser Gly Phe Leu 
        835                 840                 845             


<210>  30
<211>  495
<212>  PRT
<213>  Mus musculus

<400>  30

Met Arg Thr Gln Ile Glu Val Ile Pro Cys Lys Ile Cys Gly Asp Lys 
1               5                   10                  15      


Ser Ser Gly Ile His Tyr Gly Val Ile Thr Cys Glu Gly Cys Lys Gly 
            20                  25                  30          


Phe Phe Arg Arg Ser Gln Gln Cys Asn Val Ala Tyr Ser Cys Thr Arg 
        35                  40                  45              


Gln Gln Asn Cys Pro Ile Asp Arg Thr Ser Arg Asn Arg Cys Gln His 
    50                  55                  60                  


Cys Arg Leu Gln Lys Cys Leu Ala Leu Gly Met Ser Arg Asp Ala Val 
65                  70                  75                  80  


Lys Phe Gly Arg Met Ser Lys Lys Gln Arg Asp Ser Leu His Ala Glu 
                85                  90                  95      


Val Gln Lys Gln Leu Gln Gln Gln Gln Gln Gln Glu Gln Val Ala Lys 
            100                 105                 110         


Thr Pro Pro Ala Gly Ser Arg Gly Ala Asp Thr Leu Thr Tyr Thr Leu 
        115                 120                 125             


Gly Leu Ser Asp Gly Gln Leu Pro Leu Gly Ala Ser Pro Asp Leu Pro 
    130                 135                 140                 


Glu Ala Ser Ala Cys Pro Pro Gly Leu Leu Arg Ala Ser Gly Ser Gly 
145                 150                 155                 160 


Pro Pro Tyr Ser Asn Thr Leu Ala Lys Thr Glu Val Gln Gly Ala Ser 
                165                 170                 175     


Cys His Leu Glu Tyr Ser Pro Glu Arg Gly Lys Ala Glu Gly Arg Asp 
            180                 185                 190         


Ser Ile Tyr Ser Thr Asp Gly Gln Leu Thr Leu Gly Arg Cys Gly Leu 
        195                 200                 205             


Arg Phe Glu Glu Thr Arg His Pro Glu Leu Gly Glu Pro Glu Gln Gly 
    210                 215                 220                 


Pro Asp Ser His Cys Ile Pro Ser Phe Cys Ser Ala Pro Glu Val Pro 
225                 230                 235                 240 


Tyr Ala Ser Leu Thr Asp Ile Glu Tyr Leu Val Gln Asn Val Cys Lys 
                245                 250                 255     


Ser Phe Arg Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu Arg Gln 
            260                 265                 270         


Arg Thr Asn Leu Phe Ser Arg Glu Glu Val Thr Ser Tyr Gln Arg Lys 
        275                 280                 285             


Ser Met Trp Glu Met Trp Glu Arg Cys Ala His His Leu Thr Glu Ala 
    290                 295                 300                 


Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe Met Glu 
305                 310                 315                 320 


Leu Cys Gln Asn Asp Gln Ile Ile Leu Leu Lys Ala Gly Ala Met Glu 
                325                 330                 335     


Val Val Leu Val Arg Met Cys Arg Ala Tyr Asn Ala Asn Asn His Thr 
            340                 345                 350         


Val Phe Phe Glu Gly Lys Tyr Gly Gly Val Glu Leu Phe Arg Ala Leu 
        355                 360                 365             


Gly Cys Ser Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His Phe Leu 
    370                 375                 380                 


Ser Ala Leu Cys Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr Ala Leu 
385                 390                 395                 400 


Val Leu Ile Asn Ala Asn Arg Pro Gly Leu Gln Glu Lys Arg Arg Val 
                405                 410                 415     


Glu His Leu Gln Tyr Asn Leu Glu Leu Ala Phe His His His Leu Cys 
            420                 425                 430         


Lys Thr His Arg Gln Gly Leu Leu Ala Lys Leu Pro Pro Lys Gly Lys 
        435                 440                 445             


Leu Arg Ser Leu Cys Ser Gln His Val Glu Lys Leu Gln Ile Phe Gln 
    450                 455                 460                 


His Leu His Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu Tyr Lys 
465                 470                 475                 480 


Glu Leu Phe Ser Thr Asp Val Glu Ser Pro Glu Gly Leu Ser Lys 
                485                 490                 495 


<210>  31
<211>  1520
<212>  DNA
<213>  Mus musculus

<400>  31
atgggaaaag acctggcaat cagaggtgtg tgtgagcatt atcccaggga taatgccaag       60

ggtattatcc caagggtatc ccaagaagtg tcagaaaagc aaacatgatc caaacaggtg      120

aaagtcagag ttaccagcca gcaaaagacc tagaaagaag agcaaggtgt gaggtgctgc      180

aacttctgag aacacggtga tcatgaacag aatccagcaa tcctaccaga catgccatct      240

attgaacagg agctatcggt ccacctcatg ctgcatgtca gacaaaagct gaagagctgg      300

gacctaatga cccccatatt caccatcttg tcctcatatc tgctattcct gaagaaaaag      360

acttctcaaa gacataaagg caaaggtcat ctcatggaga ggagagaaca tgagagagct      420

gtttccatct tcccttctca tccctcatct cctcctgtta gtagtctcca cccggcagtg      480

cctcagtgtc tccactgtct ttcagccttc atcttgattt ctaattcttt cttcgattta      540

tccaatcagt cccttattct ttcacttcat ttccttcctc cttaaaagaa aggcttgata      600

ccgaacctca aaacagcaaa tattaacagg tttcttgata acatgcaacc gtaatgactt      660

cactagtaaa cctcatgtct ctcgctactc cttaataact aactagcctt tgtgattgtt      720

tcttgcagag aatagacatt caaggaaaaa cagttgcggt actcagttaa atagaacgtg      780

ttccgttggt gttaaattat ttattttgta tgtctgttta catactaaga cattgagtgg      840

gtttctttgg gcaagggatg ctctctagcc agggaatttg gtagaaaagt gagaaagatc      900

aagtcaaaat tcaaagtgtg tgtcactagg agactgtcaa gagactcaca aaccattact      960

atggagccca gctctgcagc agcttcagat atgtccatac acacatgata ctgaatcaca     1020

gcaaagcatc tctgttcagc tcccaagaag tcatgcttct ttgcatagtg aacttctgcc     1080

cttcccatct accttcgaga cagatgttgc ccgtcataaa ggggtggttc tgtgctgacc     1140

tcatttgagg atggaatctt tactcaaatg gtgtcacccc ccaacccact cttgacgtaa     1200

gtgaccacag aggtagtaaa accgtataaa aagagagaaa ggagcactac tcttcatcca     1260

cctcacacga ggcacaagtg cacccagcac cagctgatca ggacgcgcaa acatgagtcc     1320

agggagagct tcatctgtgg tgagtcctgc actaatgtac aaggcgcttg ttgattgtga     1380

ccaggttgcg ttattgcacg tgatatgaaa tgctctattc cagctgttgg ggtccatgaa     1440

tctgtacatg tagaactgga aatgaaacct ttggtagatg tcgaaatcat tgtacagcat     1500

tttcaagaac tgataggcat                                                 1520


<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  32

Asn Thr Val Trp Lys Gln Leu Ser Ser Ser Val Thr Gly Leu Thr 
1               5                   10                  15  


