                               SEQUENCE LISTING

<110> MEMORIAL SLOAN-KETTERING CANCER CENTER
 
<120> LEUCINE ZIPPER-BASED COMPOSITIONS AND METHODS OF USE

<130> 072734.0920

<140> PCT/US2019/046758
<141> 2019-08-16

<150> 62/798,168
<151> 2019-01-29

<150> 62/765,058
<151> 2018-08-16

<160> 98    

<170> PatentIn version 3.5

<210> 1
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210> 2
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg 
            20                  25                  30          


Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210> 3
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser 
            


<210> 4
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Gly Ser Gln Lys Val Glu Ser Leu Lys Gln Lys Ile Glu Glu Leu Lys 
1               5                   10                  15      


Gln Arg Lys Ala Gln Leu Lys Asn Asp Ile Ala Asn Leu Glu Lys Glu 
            20                  25                  30          


Ile Ala Tyr Ala Glu Thr 
        35              


<210> 5
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Gly Ser Glu Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu 
1               5                   10                  15      


Asp Glu Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu 
            20                  25                  30          


Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala His Arg 
        35                  40                  


<210> 6
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Glu Arg Ile Ser Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ser Gln 
1               5                   10                  15      


Asn Thr Glu Leu Ala Ser Thr Ala Ser Leu Leu Arg Glu Gln Val Ala 
            20                  25                  30          


Gln Leu Lys Gln Lys Val Leu Ser His Val Leu Glu 
        35                  40                  


<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Cys His Thr Gln Ser Ser Pro Lys Leu 
1               5                   


<210> 8
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
1               5                   10              


<210> 9
<211> 235
<212> PRT
<213> Homo sapiens

<400> 9
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210> 10
<211> 247
<212> PRT
<213> Mus musculus

<400> 10
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Met 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Lys Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Val Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Pro 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg Lys 
    210                 215                 220                 


Arg Val Cys Lys Cys Pro Arg Pro Leu Val Arg Gln Glu Gly Lys Pro 
225                 230                 235                 240 


Arg Pro Ser Glu Lys Ile Val 
                245         


<210> 11
<211> 25
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CD8 sequence

<400> 11
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu 
1               5                   10                  15      


Ser Leu Ile Ile Thr Leu Ile Cys Tyr 
            20                  25  


<210> 12
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CD8 sequence

<400> 12
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210> 13
<211> 188
<212> PRT
<213> Mus musculus

<400> 13
Met Lys Trp Lys Val Ser Val Leu Ala Cys Ile Leu His Val Arg Phe 
1               5                   10                  15      


Pro Gly Ala Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Ile Thr Ala 
        35                  40                  45              


Leu Tyr Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn 
    50                  55                  60                  


Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Asp Ser 
    130                 135                 140                 


His Phe Gln Ala Val Gln Phe Gly Asn Arg Arg Glu Arg Glu Gly Ser 
145                 150                 155                 160 


Glu Leu Thr Arg Thr Leu Gly Leu Arg Ala Arg Pro Lys Ala Cys Arg 
                165                 170                 175     


His Lys Lys Pro Leu Ser Leu Pro Ala Ala Val Ser 
            180                 185             


<210> 14
<211> 220
<212> PRT
<213> Homo sapiens

<400> 14
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210> 15
<211> 164
<212> PRT
<213> Homo sapiens

<400> 15
Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210> 16
<211> 218
<212> PRT
<213> Mus musculus

<400> 16
Met Thr Leu Arg Leu Leu Phe Leu Ala Leu Asn Phe Phe Ser Val Gln 
1               5                   10                  15      


Val Thr Glu Asn Lys Ile Leu Val Lys Gln Ser Pro Leu Leu Val Val 
            20                  25                  30          


Asp Ser Asn Glu Val Ser Leu Ser Cys Arg Tyr Ser Tyr Asn Leu Leu 
        35                  40                  45              


Ala Lys Glu Phe Arg Ala Ser Leu Tyr Lys Gly Val Asn Ser Asp Val 
    50                  55                  60                  


Glu Val Cys Val Gly Asn Gly Asn Phe Thr Tyr Gln Pro Gln Phe Arg 
65                  70                  75                  80  


Ser Asn Ala Glu Phe Asn Cys Asp Gly Asp Phe Asp Asn Glu Thr Val 
                85                  90                  95      


Thr Phe Arg Leu Trp Asn Leu His Val Asn His Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
    130                 135                 140                 


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
145                 150                 155                 160 


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
                165                 170                 175     


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
    210                 215             


<210> 17
<211> 113
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CD3-zeta sequence

<400> 17
Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
1               5                   10                  15      


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
            100                 105                 110         


Arg 
    


<210> 18
<211> 277
<212> PRT
<213> Homo sapiens

<400> 18
Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210> 19
<211> 199
<212> PRT
<213> Homo sapiens

<400> 19
Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10          


<210> 22
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  


<210> 23
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CD28 sequence

<400> 23
Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr 
            20                  25          


<210> 24
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn 
            20                  25                  30          


Thr Ala Leu Glu Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg 
        35                  40                  45              


Leu Arg Asn Arg Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly 
    50                  55                  60                  


Gly Gly Lys Gly Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
65                  70                  75                  80  


Ala Ala Ala Ser Gly Ser Leu Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                85                  90                  95      


Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr 
            100                 105                 110         


Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met Thr 
        115                 120                 125             


Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro 
    130                 135                 140                 


Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg Ser 
145                 150                 155                 160 


Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu 
                165                 170                 175     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg 
            180                 185                 190         


Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro 
        195                 200                 205             


Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala 
    210                 215                 220                 


Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
225                 230                 235                 240 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                245                 250                 255     


Ala Leu His Met Gln Thr Leu Ala Pro Arg Gly Thr Gly Gln Cys Thr 
            260                 265                 270         


Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
        275                 280                 285             


Pro Gly Ser Met Asn Pro Ala Ile Ser Val Ala Leu Leu Leu Ser Val 
    290                 295                 300                 


Leu Gln Val Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu 
305                 310                 315                 320 


Val Asn Gln Asn Leu Arg Leu Asp Cys Arg His Glu Asn Asn Thr Lys 
                325                 330                 335     


Asp Asn Ser Ile Gln His Glu Phe Ser Leu Thr Arg Glu Lys Arg Lys 
            340                 345                 350         


His Val Leu Ser Gly Thr Leu Gly Ile Pro Glu His Thr Tyr Arg Ser 
        355                 360                 365             


Arg Val Thr Leu Ser Asn Gln Pro Tyr Ile Lys Val Leu Thr Leu Ala 
    370                 375                 380                 


Asn Phe Thr Thr Lys Asp Glu Gly Asp Tyr Phe Cys Glu Leu Arg Val 
385                 390                 395                 400 


Ser Gly Ala Asn Pro Met Ser Ser Asn Lys Ser Ile Ser Val Tyr Arg 
                405                 410                 415     


Asp Lys Leu Val Lys Cys Gly Gly Ile Ser Leu Leu Val Gln Asn Thr 
            420                 425                 430         


Ser Trp Met Leu Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Leu 
        435                 440                 445             


Asp Phe Ile Ser Leu 
    450             


<210> 25
<211> 461
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn 
            20                  25                  30          


Thr Ala Leu Glu Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg 
        35                  40                  45              


Leu Arg Asn Arg Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly 
    50                  55                  60                  


Gly Gly Lys Gly Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
65                  70                  75                  80  


Ala Ala Ala Cys His Thr Gln Ser Ser Pro Lys Leu Gly Ser Leu Ile 
                85                  90                  95      


Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser 
            100                 105                 110         


Leu Ile Ile Thr Leu Ile Cys Tyr Asn Ser Arg Arg Asn Arg Leu Leu 
        115                 120                 125             


Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg 
    130                 135                 140                 


Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg 
145                 150                 155                 160 


Pro Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln 
                165                 170                 175     


Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            180                 185                 190         


Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly 
        195                 200                 205             


Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu 
    210                 215                 220                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly 
225                 230                 235                 240 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                245                 250                 255     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala 
            260                 265                 270         


Pro Arg Gly Thr Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala 
        275                 280                 285             


Gly Asp Val Glu Ser Asn Pro Gly Pro Gly Ser Met Asn Pro Ala Ile 
    290                 295                 300                 


Ser Val Ala Leu Leu Leu Ser Val Leu Gln Val Ser Arg Gly Gln Lys 
305                 310                 315                 320 


Val Thr Ser Leu Thr Ala Cys Leu Val Asn Gln Asn Leu Arg Leu Asp 
                325                 330                 335     


Cys Arg His Glu Asn Asn Thr Lys Asp Asn Ser Ile Gln His Glu Phe 
            340                 345                 350         


Ser Leu Thr Arg Glu Lys Arg Lys His Val Leu Ser Gly Thr Leu Gly 
        355                 360                 365             


Ile Pro Glu His Thr Tyr Arg Ser Arg Val Thr Leu Ser Asn Gln Pro 
    370                 375                 380                 


Tyr Ile Lys Val Leu Thr Leu Ala Asn Phe Thr Thr Lys Asp Glu Gly 
385                 390                 395                 400 


Asp Tyr Phe Cys Glu Leu Arg Val Ser Gly Ala Asn Pro Met Ser Ser 
                405                 410                 415     


Asn Lys Ser Ile Ser Val Tyr Arg Asp Lys Leu Val Lys Cys Gly Gly 
            420                 425                 430         


Ile Ser Leu Leu Val Gln Asn Thr Ser Trp Met Leu Leu Leu Leu Leu 
        435                 440                 445             


Ser Leu Ser Leu Leu Gln Ala Leu Asp Phe Ile Ser Leu 
    450                 455                 460     


<210> 26
<211> 478
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gly Ser Gly Gly Lys Pro Ile Pro Asn Pro Leu Leu 
            20                  25                  30          


Gly Leu Asp Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Glu 
        35                  40                  45              


Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu Thr Arg 
    50                  55                  60                  


Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg Val Ser 
65                  70                  75                  80  


Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Ala Ala Ala 
                85                  90                  95      


Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Gly Ser Leu 
            100                 105                 110         


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu 
        115                 120                 125             


Ser Leu Ile Ile Thr Leu Ile Cys Tyr Asn Ser Arg Arg Asn Arg Leu 
    130                 135                 140                 


Leu Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr 
145                 150                 155                 160 


Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr 
                165                 170                 175     


Arg Pro Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu 
            180                 185                 190         


Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        195                 200                 205             


Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly 
    210                 215                 220                 


Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala 
225                 230                 235                 240 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys 
                245                 250                 255     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            260                 265                 270         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu 
        275                 280                 285             


Ala Pro Arg Gly Thr Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu 
    290                 295                 300                 


Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Gly Ser Met Asn Pro Ala 
305                 310                 315                 320 


Ile Ser Val Ala Leu Leu Leu Ser Val Leu Gln Val Ser Arg Gly Gln 
                325                 330                 335     


Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asn Gln Asn Leu Arg Leu 
            340                 345                 350         


Asp Cys Arg His Glu Asn Asn Thr Lys Asp Asn Ser Ile Gln His Glu 
        355                 360                 365             


Phe Ser Leu Thr Arg Glu Lys Arg Lys His Val Leu Ser Gly Thr Leu 
    370                 375                 380                 


Gly Ile Pro Glu His Thr Tyr Arg Ser Arg Val Thr Leu Ser Asn Gln 
385                 390                 395                 400 


Pro Tyr Ile Lys Val Leu Thr Leu Ala Asn Phe Thr Thr Lys Asp Glu 
                405                 410                 415     


Gly Asp Tyr Phe Cys Glu Leu Arg Val Ser Gly Ala Asn Pro Met Ser 
            420                 425                 430         


Ser Asn Lys Ser Ile Ser Val Tyr Arg Asp Lys Leu Val Lys Cys Gly 
        435                 440                 445             


Gly Ile Ser Leu Leu Val Gln Asn Thr Ser Trp Met Leu Leu Leu Leu 
    450                 455                 460                 


Leu Ser Leu Ser Leu Leu Gln Ala Leu Asp Phe Ile Ser Leu 
465                 470                 475             


<210> 27
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro 
        195                 200                 205             


Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
    210                 215                 220                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly Gly Ser Gly Ala Thr 
225                 230                 235                 240 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                245                 250                 255     


Pro Glu Phe Thr Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu 
            260                 265                 270         


Leu Trp Val Pro Gly Ser Thr Gly Gly Ser Gly Gly Lys Pro Ile Pro 
        275                 280                 285             


Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Ser Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala 
305                 310                 315                 320 


Leu Glu Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg 
                325                 330                 335     


Asn Arg Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly 
            340                 345                 350         


Lys Ala Ala Ala Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
        355                 360                 365             


Thr Gly Ser Leu Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val 
    370                 375                 380                 


Ala Leu Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr Asn Ser Arg 
385                 390                 395                 400 


Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                405                 410                 415     


Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp 
            420                 425                 430         


Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr 
        435                 440                 445             


Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    450                 455                 460                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp 
465                 470                 475                 480 


Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly 
                485                 490                 495     


Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            500                 505                 510         


Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        515                 520                 525             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    530                 535                 540                 


Met Gln Thr Leu Ala Pro Arg Gly Thr Gly Gln Cys Thr Asn Tyr Ala 
545                 550                 555                 560 


Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Gly Ser 
                565                 570                 575     


Met Asn Pro Ala Ile Ser Val Ala Leu Leu Leu Ser Val Leu Gln Val 
            580                 585                 590         


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asn Gln 
        595                 600                 605             


Asn Leu Arg Leu Asp Cys Arg His Glu Asn Asn Thr Lys Asp Asn Ser 
    610                 615                 620                 


Ile Gln His Glu Phe Ser Leu Thr Arg Glu Lys Arg Lys His Val Leu 
625                 630                 635                 640 


Ser Gly Thr Leu Gly Ile Pro Glu His Thr Tyr Arg Ser Arg Val Thr 
                645                 650                 655     


Leu Ser Asn Gln Pro Tyr Ile Lys Val Leu Thr Leu Ala Asn Phe Thr 
            660                 665                 670         


Thr Lys Asp Glu Gly Asp Tyr Phe Cys Glu Leu Arg Val Ser Gly Ala 
        675                 680                 685             


Asn Pro Met Ser Ser Asn Lys Ser Ile Ser Val Tyr Arg Asp Lys Leu 
    690                 695                 700                 


Val Lys Cys Gly Gly Ile Ser Leu Leu Val Gln Asn Thr Ser Trp Met 
705                 710                 715                 720 


Leu Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Leu Asp Phe Ile 
                725                 730                 735     


Ser Leu 
        


<210> 28
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn 
            20                  25                  30          


Thr Ala Leu Glu Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg 
        35                  40                  45              


Leu Arg Asn Arg Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly 
    50                  55                  60                  


Gly Gly Lys Gly Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
65                  70                  75                  80  


Ala Ala Ala Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro 
                85                  90                  95      


Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg 
            100                 105                 110         


Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile 
        115                 120                 125             


Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser 
    130                 135                 140                 


Leu Ile Ile Thr Leu Ile Cys Tyr Asn Ser Arg Arg Asn Arg Leu Leu 
145                 150                 155                 160 


Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg 
                165                 170                 175     


Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg 
            180                 185                 190         


Pro Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln 
        195                 200                 205             


Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    210                 215                 220                 


Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly 
225                 230                 235                 240 


Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu 
                245                 250                 255     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly 
            260                 265                 270         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        275                 280                 285             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala 
    290                 295                 300                 


Pro Arg Gly Thr Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala 
305                 310                 315                 320 


Gly Asp Val Glu Ser Asn Pro Gly Pro Gly Ser Met Asn Pro Ala Ile 
                325                 330                 335     


Ser Val Ala Leu Leu Leu Ser Val Leu Gln Val Ser Arg Gly Gln Lys 
            340                 345                 350         


Val Thr Ser Leu Thr Ala Cys Leu Val Asn Gln Asn Leu Arg Leu Asp 
        355                 360                 365             


Cys Arg His Glu Asn Asn Thr Lys Asp Asn Ser Ile Gln His Glu Phe 
    370                 375                 380                 


Ser Leu Thr Arg Glu Lys Arg Lys His Val Leu Ser Gly Thr Leu Gly 
385                 390                 395                 400 


Ile Pro Glu His Thr Tyr Arg Ser Arg Val Thr Leu Ser Asn Gln Pro 
                405                 410                 415     


Tyr Ile Lys Val Leu Thr Leu Ala Asn Phe Thr Thr Lys Asp Glu Gly 
            420                 425                 430         


Asp Tyr Phe Cys Glu Leu Arg Val Ser Gly Ala Asn Pro Met Ser Ser 
        435                 440                 445             


Asn Lys Ser Ile Ser Val Tyr Arg Asp Lys Leu Val Lys Cys Gly Gly 
    450                 455                 460                 


Ile Ser Leu Leu Val Gln Asn Thr Ser Trp Met Leu Leu Leu Leu Leu 
465                 470                 475                 480 


Ser Leu Ser Leu Leu Gln Ala Leu Asp Phe Ile Ser Leu 
                485                 490             


<210> 29
<211> 324
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Glu Phe Thr Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Ile Arg Ala 
1               5                   10                  15      


Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu 
            20                  25                  30          


Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu 
        35                  40                  45              


Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Ser Gly Arg Ala Lys 
    50                  55                  60                  


Arg Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
65                  70                  75                  80  


Asn Pro Gly Pro Thr Arg Thr Gly Leu Glu Ser Met Ser Glu Leu Ile 
                85                  90                  95      


Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn 
            100                 105                 110         


His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly 
        115                 120                 125             


Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe 
    130                 135                 140                 


Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe 
145                 150                 155                 160 


Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro 
                165                 170                 175     


Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val 
            180                 185                 190         


Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr 
        195                 200                 205             


Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met 
    210                 215                 220                 


Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro 
225                 230                 235                 240 


Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val 
                245                 250                 255     


Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys 
            260                 265                 270         


Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr 
        275                 280                 285             


Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln 
    290                 295                 300                 


His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly 
305                 310                 315                 320 


His Lys Leu Asn 
                


<210> 30
<211> 87
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Glu Phe Thr Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Ile Arg Ala 
1               5                   10                  15      


Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu 
            20                  25                  30          


Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu 
        35                  40                  45              


Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Ser Gly Arg Ala Lys 
    50                  55                  60                  


Arg Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
65                  70                  75                  80  


Asn Pro Gly Pro Thr Arg Thr 
                85          


<210> 31
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Arg Ser Gly Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Ile Arg Ala 
1               5                   10                  15      


Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu 
            20                  25                  30          


Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu 
        35                  40                  45              


Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Ser Gly Gly Ser Gly 
    50                  55                  60                  


Arg Ala Lys Arg Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly 
65                  70                  75                  80  


Asp Val Glu Ser Asn Pro Gly Pro Gly Ser Leu Gly Ser Gly Leu Glu 
                85                  90                  95      


Ser Met Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met 
            100                 105                 110         


Glu Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu 
        115                 120                 125             


Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu 
    130                 135                 140                 


Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu 
145                 150                 155                 160 


Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe 
                165                 170                 175     


Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr 
            180                 185                 190         


Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln 
        195                 200                 205             


Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr 
    210                 215                 220                 


Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe 
225                 230                 235                 240 


Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp 
                245                 250                 255     


Met Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys 
            260                 265                 270         


Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly 
        275                 280                 285             


Val Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn 
    290                 295                 300                 


Glu Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp 
305                 310                 315                 320 


Leu Pro Ser Lys Leu Gly His Lys Leu Asn 
                325                 330 


<210> 32
<211> 87
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Glu Phe Thr Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Ile Arg Ala 
1               5                   10                  15      


Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu 
            20                  25                  30          


Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu 
        35                  40                  45              


Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Ser Gly Arg Ala Lys 
    50                  55                  60                  


Arg Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
65                  70                  75                  80  


Asn Pro Gly Pro Thr Arg Thr 
                85          


<210> 33
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Arg Ser Gly Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Ile Arg Ala 
1               5                   10                  15      


Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu 
            20                  25                  30          


Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu 
        35                  40                  45              


Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Ser Gly Gly Ser Gly 
    50                  55                  60                  


Arg Ala Lys Arg Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly 
65                  70                  75                  80  


Asp Val Glu Ser Asn Pro Gly Pro Gly Ser Leu Met Val Leu Ala Ser 
                85                  90                  95      


Ser Thr Thr Ser Ile His Thr Met Leu Leu Leu Leu Leu Met Leu Phe 
            100                 105                 110         


His Leu Gly Leu Gln Ala Ser Ile Ser Gly Arg Asp Thr His Arg Leu 
        115                 120                 125             


Thr Arg Thr Leu Asn Cys Ser Ser Ile Val Lys Glu Ile Ile Gly Lys 
    130                 135                 140                 


Leu Pro Glu Pro Glu Leu Lys Thr Asp Asp Glu Gly Pro Ser Leu Arg 
145                 150                 155                 160 


Asn Lys Ser Phe Arg Arg Val Asn Leu Ser Lys Phe Val Glu Ser Gln 
                165                 170                 175     


Gly Glu Val Asp Pro Glu Asp Arg Tyr Val Ile Lys Ser Asn Leu Gln 
            180                 185                 190         


Lys Leu Asn Cys Cys Leu Pro Thr Ser Ala Asn Asp Ser Ala Leu Pro 
        195                 200                 205             


Gly Val Phe Ile Arg Asp Leu Asp Asp Phe Arg Lys Lys Leu Arg Phe 
    210                 215                 220                 


Tyr Met Val His Leu Asn Asp Leu Glu Thr Val Leu Thr Ser Arg Pro 
225                 230                 235                 240 


Pro Gln Pro Ala Ser Gly Ser Val Ser Pro Asn Arg Gly Thr Val Glu 
                245                 250                 255     


Cys Gly Ser Gly Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Ile Arg 
            260                 265                 270         


Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala 
        275                 280                 285             


Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr 
    290                 295                 300                 


Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Ser Gly Arg Ala 
305                 310                 315                 320 


Lys Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
                325                 330                 335     


Asn Pro Gly Pro Leu Glu Ser Met Ser Glu Leu Ile Lys Glu Asn Met 
            340                 345                 350         


His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His His Phe Lys 
        355                 360                 365             


Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met 
    370                 375                 380                 


Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile 
385                 390                 395                 400 


Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn His Thr 
                405                 410                 415     


Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr 
            420                 425                 430         


Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr 
        435                 440                 445             


Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile 
    450                 455                 460                 


Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln Lys Lys Thr 
465                 470                 475                 480 


Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly 
                485                 490                 495     


Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly Gly Ser His 
            500                 505                 510         


Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys 
        515                 520                 525             


Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu Glu Arg 
    530                 535                 540                 


Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His Glu Val Ala 
545                 550                 555                 560 


Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu Asn 
                565                 570                 575     


<210> 34
<211> 478
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Thr Ser Ser Glu Cys His Ile Lys Asp Lys 
            20                  25                  30          


Glu Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu 
        35                  40                  45              


Asp Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn 
    50                  55                  60                  


Phe Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu 
65                  70                  75                  80  


Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      


Glu Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr 
            100                 105                 110         


Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys 
        115                 120                 125             


Lys Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr 
    130                 135                 140                 


Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile Glu Phe Thr Asp Tyr Lys 
145                 150                 155                 160 


Asp Asp Asp Asp Lys Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg 
                165                 170                 175     


Asn Thr Ala Leu Arg Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln 
            180                 185                 190         


Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu 
        195                 200                 205             


Gly Gly Gly Lys Gly Ser Gly Arg Ala Lys Arg Ala Thr Asn Phe Ser 
    210                 215                 220                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Thr Arg 
225                 230                 235                 240 


Thr Gly Leu Glu Ser Met Ser Glu Leu Ile Lys Glu Asn Met His Met 
                245                 250                 255     


Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His His Phe Lys Cys Thr 
            260                 265                 270         


Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile 
        275                 280                 285             


Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala 
    290                 295                 300                 


Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly 
305                 310                 315                 320 


Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu 
                325                 330                 335     


Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp 
            340                 345                 350         


Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly 
        355                 360                 365             


Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly 
    370                 375                 380                 


Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu 
385                 390                 395                 400 


Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile 
                405                 410                 415     


Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu 
            420                 425                 430         


Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys 
        435                 440                 445             


Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His Glu Val Ala Val Ala 
    450                 455                 460                 


Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu Asn 
465                 470                 475             


<210> 35
<211> 464
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile 
            20                  25                  30          


Glu Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp 
        35                  40                  45              


Ser Asp Phe His Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu 
    50                  55                  60                  


Leu Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn 
65                  70                  75                  80  


Glu Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser 
                85                  90                  95      


Asn Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            100                 105                 110         


Glu Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln 
        115                 120                 125             


Met Phe Ile Asn Thr Ser Arg Ser Gly Asp Tyr Lys Asp Asp Asp Asp 
    130                 135                 140                 


Lys Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu 
145                 150                 155                 160 


Arg Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn 
                165                 170                 175     


Glu Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
            180                 185                 190         


Gly Ser Gly Gly Ser Gly Arg Ala Lys Arg Gln Cys Thr Asn Tyr Ala 
        195                 200                 205             


Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Gly Ser 
    210                 215                 220                 


Leu Gly Ser Gly Leu Glu Ser Met Ser Glu Leu Ile Lys Glu Asn Met 
225                 230                 235                 240 


His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His His Phe Lys 
                245                 250                 255     


Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met 
            260                 265                 270         


Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile 
        275                 280                 285             


Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn His Thr 
    290                 295                 300                 


Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr 
305                 310                 315                 320 


Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr 
                325                 330                 335     


Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile 
            340                 345                 350         


Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln Lys Lys Thr 
        355                 360                 365             


Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly 
    370                 375                 380                 


Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly Gly Ser His 
385                 390                 395                 400 


Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys 
                405                 410                 415     


Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu Glu Arg 
            420                 425                 430         


Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His Glu Val Ala 
        435                 440                 445             


Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu Asn 
    450                 455                 460                 


<210> 36
<211> 470
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Glu Arg Thr Leu Val Cys Leu Val Val Ile Phe Leu Gly Thr Val 
1               5                   10                  15      


Ala His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu 
            20                  25                  30          


Arg His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp 
        35                  40                  45              


Leu Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys 
    50                  55                  60                  


Glu His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser 
65                  70                  75                  80  


Asn Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu 
                85                  90                  95      


Arg Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile 
            100                 105                 110         


Ala Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu 
        115                 120                 125             


Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140                 


Leu Ser Glu Phe Thr Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Ile 
145                 150                 155                 160 


Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val 
                165                 170                 175     


Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln 
            180                 185                 190         


Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Ser Gly Arg 
        195                 200                 205             


Ala Lys Arg Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
    210                 215                 220                 


Glu Glu Asn Pro Gly Pro Thr Arg Thr Gly Leu Glu Ser Met Ser Glu 
225                 230                 235                 240 


Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val 
                245                 250                 255     


Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr 
            260                 265                 270         


Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu 
        275                 280                 285             


Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys 
    290                 295                 300                 


Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser 
305                 310                 315                 320 


Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly 
                325                 330                 335     


Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu 
            340                 345                 350         


Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro 
        355                 360                 365             


Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu 
    370                 375                 380                 


Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys 
385                 390                 395                 400 


Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg 
                405                 410                 415     


Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val 
            420                 425                 430         


Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val 
        435                 440                 445             


Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys 
    450                 455                 460                 


Leu Gly His Lys Leu Asn 
465                 470 


<210> 37
<211> 482
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu 
            20                  25                  30          


Ile Arg Leu Arg His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr 
        35                  40                  45              


Glu Asn Asp Leu Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys 
    50                  55                  60                  


Gly His Cys Glu His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu 
65                  70                  75                  80  


Lys Pro Ser Asn Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val 
                85                  90                  95      


Ala Gln Leu Arg Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln 
            100                 105                 110         


Lys His Ile Ala Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr 
        115                 120                 125             


Pro Lys Glu Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile 
    130                 135                 140                 


His Gln His Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Phe 
145                 150                 155                 160 


Thr Asp Tyr Lys Asp Asp Asp Asp Lys Leu Glu Ile Arg Ala Ala Phe 
                165                 170                 175     


Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala Glu Leu Glu 
            180                 185                 190         


Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu Thr Arg 
        195                 200                 205             


Tyr Gly Pro Leu Gly Gly Gly Lys Gly Ser Gly Arg Ala Lys Arg Ala 
    210                 215                 220                 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
225                 230                 235                 240 


Gly Pro Thr Arg Thr Gly Leu Glu Ser Met Ser Glu Leu Ile Lys Glu 
                245                 250                 255     


Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His His 
            260                 265                 270         


Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln 
        275                 280                 285             


Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe 
    290                 295                 300                 


Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn 
305                 310                 315                 320 


His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly 
                325                 330                 335     


Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr 
            340                 345                 350         


Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val 
        355                 360                 365             


Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln Lys 
    370                 375                 380                 


Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp 
385                 390                 395                 400 


Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly Gly 
                405                 410                 415     


Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys Pro 
            420                 425                 430         


Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu 
        435                 440                 445             


Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His Glu 
    450                 455                 460                 


Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys 
465                 470                 475                 480 


Leu Asn 
        


<210> 38
<211> 705
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Thr Ser Ser Glu Cys His Ile Lys Asp Lys 
            20                  25                  30          


Glu Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu 
        35                  40                  45              


Asp Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn 
    50                  55                  60                  


Phe Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu 
65                  70                  75                  80  


Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      


Glu Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr 
            100                 105                 110         


Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys 
        115                 120                 125             


Lys Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr 
    130                 135                 140                 


Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile Glu Phe Thr Asp Tyr Lys 
145                 150                 155                 160 


Asp Asp Asp Asp Lys Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg 
                165                 170                 175     


Asn Thr Ala Leu Arg Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln 
            180                 185                 190         


Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu 
        195                 200                 205             


Gly Gly Gly Lys Gly Ser Gly Arg Ala Lys Arg Ala Thr Asn Phe Ser 
    210                 215                 220                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Thr Arg 
225                 230                 235                 240 


Thr Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val 
                245                 250                 255     


Leu Leu Val Asn Ser Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys 
            260                 265                 270         


Ile Glu Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr 
        275                 280                 285             


Asp Ser Asp Phe His Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe 
    290                 295                 300                 


Leu Leu Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu 
305                 310                 315                 320 


Asn Glu Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser 
                325                 330                 335     


Ser Asn Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            340                 345                 350         


Glu Glu Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val 
        355                 360                 365             


Gln Met Phe Ile Asn Thr Ser Arg Ser Gly Asp Tyr Lys Asp Asp Asp 
    370                 375                 380                 


Asp Lys Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala 
385                 390                 395                 400 


Leu Arg Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu 
                405                 410                 415     


Asn Glu Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly 
            420                 425                 430         


Lys Gly Ser Gly Gly Ser Gly Arg Ala Lys Arg Gln Cys Thr Asn Tyr 
        435                 440                 445             


Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Gly 
    450                 455                 460                 


Ser Leu Gly Ser Gly Leu Glu Ser Met Ser Glu Leu Ile Lys Glu Asn 
465                 470                 475                 480 


Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His His Phe 
                485                 490                 495     


Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr 
            500                 505                 510         


Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp 
        515                 520                 525             


Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile Asn His 
    530                 535                 540                 


Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe 
545                 550                 555                 560 


Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Ala 
                565                 570                 575     


Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys 
            580                 585                 590         


Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln Lys Lys 
        595                 600                 605             


Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala Asp Gly 
    610                 615                 620                 


Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly Gly Ser 
625                 630                 635                 640 


His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala 
                645                 650                 655     


Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg Leu Glu 
            660                 665                 670         


Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His Glu Val 
        675                 680                 685             


Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu 
    690                 695                 700                 


Asn 
705 


<210> 39
<211> 20
<212> PRT
<213> Equine rhinitis A virus

<400> 39
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 40
<211> 22
<212> PRT
<213> Foot-and-mouth disease virus

<400> 40
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210> 41
<211> 19
<212> PRT
<213> Porcine teschovirus 1

<400> 41
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210> 42
<211> 18
<212> PRT
<213> Thosea asigna virus

<400> 42
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 44
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 45
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser 
            20              


<210> 46
<211> 20
<212> PRT
<213> Mus musculus

<400> 46
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210> 47
<211> 27
<212> PRT
<213> Mus musculus

<400> 47
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala 
            20                  25          


<210> 48
<211> 20
<212> PRT
<213> Mus musculus

<400> 48
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser 
            20  


<210> 49
<211> 26
<212> PRT
<213> Mus musculus

<400> 49
Met Val Leu Ala Ser Ser Thr Thr Ser Ile His Thr Met Leu Leu Leu 
1               5                   10                  15      


Leu Leu Met Leu Phe His Leu Gly Leu Gln 
            20                  25      


<210> 50
<211> 25
<212> PRT
<213> Mus musculus

<400> 50
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Thr Ser Ser 
            20                  25  


<210> 51
<211> 17
<212> PRT
<213> Mus musculus

<400> 51
Met Glu Arg Thr Leu Val Cys Leu Val Val Ile Phe Leu Gly Thr Val 
1               5                   10                  15      


Ala 
    


<210> 52
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
1               5                   10                  15      


Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
            20                  25                  30          


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly 
        35                  40                  45              


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr 
    50                  55                  60                  


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
65                  70                  75                  80  


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
                85                  90                  95      


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
            100                 105                 110         


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 
        115                 120                 125             


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
    210                 215                 220                 


Pro Ser Lys Leu Gly His Lys Leu Asn 
225                 230             


<210> 53
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro 
        195                 200                 205             


Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
    210                 215                 220                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly 
225                 230                 235 


<210> 54
<211> 166
<212> PRT
<213> Mus musculus

<400> 54
Met Val Leu Ala Ser Ser Thr Thr Ser Ile His Thr Met Leu Leu Leu 
1               5                   10                  15      


Leu Leu Met Leu Phe His Leu Gly Leu Gln Ala Ser Ile Ser Gly Arg 
            20                  25                  30          


Asp Thr His Arg Leu Thr Arg Thr Leu Asn Cys Ser Ser Ile Val Lys 
        35                  40                  45              


Glu Ile Ile Gly Lys Leu Pro Glu Pro Glu Leu Lys Thr Asp Asp Glu 
    50                  55                  60                  


Gly Pro Ser Leu Arg Asn Lys Ser Phe Arg Arg Val Asn Leu Ser Lys 
65                  70                  75                  80  


Phe Val Glu Ser Gln Gly Glu Val Asp Pro Glu Asp Arg Tyr Val Ile 
                85                  90                  95      


Lys Ser Asn Leu Gln Lys Leu Asn Cys Cys Leu Pro Thr Ser Ala Asn 
            100                 105                 110         


Asp Ser Ala Leu Pro Gly Val Phe Ile Arg Asp Leu Asp Asp Phe Arg 
        115                 120                 125             


Lys Lys Leu Arg Phe Tyr Met Val His Leu Asn Asp Leu Glu Thr Val 
    130                 135                 140                 


Leu Thr Ser Arg Pro Pro Gln Pro Ala Ser Gly Ser Val Ser Pro Asn 
145                 150                 155                 160 


Arg Gly Thr Val Glu Cys 
                165     


<210> 55
<211> 154
<212> PRT
<213> Mus musculus

<400> 55
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Thr Ser Ser Glu Cys His Ile Lys Asp Lys 
            20                  25                  30          


Glu Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu 
        35                  40                  45              


Asp Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn 
    50                  55                  60                  


Phe Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu 
65                  70                  75                  80  


Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      


Glu Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr 
            100                 105                 110         


Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys 
        115                 120                 125             


Lys Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr 
    130                 135                 140                 


Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile 
145                 150                 


<210> 56
<211> 162
<212> PRT
<213> Mus musculus

<400> 56
Met Lys Ile Leu Lys Pro Tyr Met Arg Asn Thr Ser Ile Ser Cys Tyr 
1               5                   10                  15      


Leu Cys Phe Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile 
    50                  55                  60                  


Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg 
            100                 105                 110         


Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val 
        115                 120                 125             


Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe 
    130                 135                 140                 


Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210> 57
<211> 146
<212> PRT
<213> Mus musculus

<400> 57
Met Glu Arg Thr Leu Val Cys Leu Val Val Ile Phe Leu Gly Thr Val 
1               5                   10                  15      


Ala His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu 
            20                  25                  30          


Arg His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp 
        35                  40                  45              


Leu Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys 
    50                  55                  60                  


Glu His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser 
65                  70                  75                  80  


Asn Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu 
                85                  90                  95      


Arg Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile 
            100                 105                 110         


Ala Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu 
        115                 120                 125             


Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140                 


Leu Ser 
145     


<210> 58
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 58
ctggagatcc gcgctgcatt tttgcgacaa agaaataccg ctttgcgaac cgaagtggcc       60

gagttggagc aggaagtaca acgcctggaa aatgaagtca gccaatacga aactcgatat      120

ggacctctcg gaggtggaaa g                                                141


<210> 59
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Leu Glu Ile Glu Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210> 60
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210> 61
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 61
ctggagatcg aagctgcatt tttgcgacaa agaaataccg ctttgcgaac cgaagtggcc       60

gagttggagc aggaagtaca acgcctggaa aatgaagtca gccaatacga aactcgatat      120

ggacctctcg gaggtggaaa g                                                141


<210> 62
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 62
ctggagatcc gcgctgcatt tttgcgacaa agaaataccg ctttgcgaac ccgcgtggcc       60

gagttggagc aggaagtaca acgcctggaa aatgaagtca gccaatacga aactcgatat      120

ggacctctcg gaggtggaaa g                                                141


<210> 63
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Leu Glu Ile Glu Ala Ala Phe Leu Arg Gln Glu Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210> 64
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Glu Gln Arg Val Gln Arg Leu Glu Asn Glu 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210> 65
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 65
ctggagatcg aagctgcatt tttgcgacaa gaaaataccg ctttgcgaac cgaagtggcc       60

gagttggagc aggaagtaca acgcctggaa aatgaagtca gccaatacga aactcgatat      120

ggacctctcg gaggtggaaa g                                                141


<210> 66
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 66
ctggagatcc gcgctgcatt tttgcgacaa agaaataccg ctttgcgaac ccgcgtggcc       60

gagttggagc agcgcgtaca acgcctggaa aatgaagtca gccaatacga aactcgatat      120

ggacctctcg gaggtggaaa g                                                141


<210> 67
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Leu Glu Ile Glu Ala Ala Phe Leu Arg Gln Glu Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210> 68
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Glu Gln Arg Val Gln Arg Leu Glu Asn Arg 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210> 69
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 69
ctggagatcg aagctgcatt tttgcgacaa gaaaataccg ctttgcgaac ccgagtggcc       60

gagttggagc aggaagtaca acgcctggaa aatgaagtca gccaatacga aactcgatat      120

ggacctctcg gaggtggaaa g                                                141


<210> 70
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 70
ctggagatcc gcgctgcatt tttgcgacaa agaaataccg ctttgcgaac ccgagtggcc       60

gagttggagc agcgagtaca acgcctggaa aatcgagtca gccaatacga aactcgatat      120

ggacctctcg gaggtggaaa g                                                141


<210> 71
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 71
ctggagattg aggctgcatt tcttgaaaga gaaaacactg ctcttgagac aagagtcgcc       60

gaactgaggc agcgcgttca gcgcctgcgg aaccgagtat ctcaatacag gactcggtac      120

ggaccactgg ggggcggtaa g                                                141


<210> 72
<211> 269
<212> PRT
<213> Mus musculus

<400> 72
Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp Lys Val Leu Leu Pro 
1               5                   10                  15      


Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser Glu Asp Arg Ile Tyr 
            20                  25                  30          


Trp Gln Lys His Asp Lys Val Val Leu Ser Val Ile Ala Gly Lys Leu 
        35                  40                  45              


Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu Tyr Asp Asn Thr Thr 
    50                  55                  60                  


Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser Asp Arg Gly Thr Tyr 
65                  70                  75                  80  


Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr Tyr Glu Val Lys His 
                85                  90                  95      


Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp Phe Ser Thr Pro Asn 
            100                 105                 110         


Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr Lys Arg Ile Thr Cys 
        115                 120                 125             


Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp Phe Asn Thr Thr Arg 
                165                 170                 175     


Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly Asp Ala His Val Ser 
            180                 185                 190         


Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp Pro Pro Asp Ser Lys 
        195                 200                 205             


Asn Thr Leu Val Leu Phe Gly Ala Gly Phe Gly Ala Val Ile Thr Val 
    210                 215                 220                 


Val Val Ile Val Val Ile Ile Lys Cys Phe Cys Lys His Arg Ser Cys 
225                 230                 235                 240 


Phe Arg Arg Asn Glu Ala Ser Arg Glu Thr Asn Asn Ser Leu Thr Phe 
                245                 250                 255     


Gly Pro Glu Glu Ala Leu Ala Glu Gln Thr Val Phe Leu 
            260                 265                 


<210> 73
<211> 254
<212> PRT
<213> Homo sapiens

<400> 73
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
    210                 215                 220                 


Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg 
225                 230                 235                 240 


Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
                245                 250                 


<210> 74
<211> 309
<212> PRT
<213> Mus musculus

<400> 74
Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      


Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          


Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              


Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  


Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  


Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      


Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 


Asp Asn Pro Trp Glu 
305                 


<210> 75
<211> 254
<212> PRT
<213> Homo sapiens

<400> 75
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210> 76
<211> 145
<212> PRT
<213> Mus musculus

<400> 76
Leu Glu Val Pro Asn Gly Pro Trp Arg Ser Leu Thr Phe Tyr Pro Ala 
1               5                   10                  15      


Trp Leu Thr Val Ser Glu Gly Ala Asn Ala Thr Phe Thr Cys Ser Leu 
            20                  25                  30          


Ser Asn Trp Ser Glu Asp Leu Met Leu Asn Trp Asn Arg Leu Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Glu Lys Gln Ala Ala Phe Cys Asn Gly Leu Ser Gln 
    50                  55                  60                  


Pro Val Gln Asp Ala Arg Phe Gln Ile Ile Gln Leu Pro Asn Arg His 
65                  70                  75                  80  


Asp Phe His Met Asn Ile Leu Asp Thr Arg Arg Asn Asp Ser Gly Ile 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu His Pro Lys Ala Lys Ile Glu Glu 
            100                 105                 110         


Ser Pro Gly Ala Glu Leu Val Val Thr Glu Arg Ile Leu Glu Thr Ser 
        115                 120                 125             


Thr Arg Tyr Pro Ser Pro Ser Pro Lys Pro Glu Gly Arg Phe Gln Gly 
    130                 135                 140                 


Met 
145 


<210> 77
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 77
Cys Pro Tyr Ser Asn Pro Ser Leu Cys 
1               5                   


<210> 78
<211> 457
<212> PRT
<213> Mus musculus

<400> 78
Met Cys Arg Ala Ile Ser Leu Arg Arg Leu Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Leu Ser Gln Leu Leu Ala Val Thr Gln Gly Lys Thr Leu Val Leu Gly 
            20                  25                  30          


Lys Glu Gly Glu Ser Ala Glu Leu Pro Cys Glu Ser Ser Gln Lys Lys 
        35                  40                  45              


Ile Thr Val Phe Thr Trp Lys Phe Ser Asp Gln Arg Lys Ile Leu Gly 
    50                  55                  60                  


Gln His Gly Lys Gly Val Leu Ile Arg Gly Gly Ser Pro Ser Gln Phe 
65                  70                  75                  80  


Asp Arg Phe Asp Ser Lys Lys Gly Ala Trp Glu Lys Gly Ser Phe Pro 
                85                  90                  95      


Leu Ile Ile Asn Lys Leu Lys Met Glu Asp Ser Gln Thr Tyr Ile Cys 
            100                 105                 110         


Glu Leu Glu Asn Arg Lys Glu Glu Val Glu Leu Trp Val Phe Lys Val 
        115                 120                 125             


Thr Phe Ser Pro Gly Thr Ser Leu Leu Gln Gly Gln Ser Leu Thr Leu 
    130                 135                 140                 


Thr Leu Asp Ser Asn Ser Lys Val Ser Asn Pro Leu Thr Glu Cys Lys 
145                 150                 155                 160 


His Lys Lys Gly Lys Val Val Ser Gly Ser Lys Val Leu Ser Met Ser 
                165                 170                 175     


Asn Leu Arg Val Gln Asp Ser Asp Phe Trp Asn Cys Thr Val Thr Leu 
            180                 185                 190         


Asp Gln Lys Lys Asn Trp Phe Gly Met Thr Leu Ser Val Leu Gly Phe 
        195                 200                 205             


Gln Ser Thr Ala Ile Thr Ala Tyr Lys Ser Glu Gly Glu Ser Ala Glu 
    210                 215                 220                 


Phe Ser Phe Pro Leu Asn Phe Ala Glu Glu Asn Gly Trp Gly Glu Leu 
225                 230                 235                 240 


Met Trp Lys Ala Glu Lys Asp Ser Phe Phe Gln Pro Trp Ile Ser Phe 
                245                 250                 255     


Ser Ile Lys Asn Lys Glu Val Ser Val Gln Lys Ser Thr Lys Asp Leu 
            260                 265                 270         


Lys Leu Gln Leu Lys Glu Thr Leu Pro Leu Thr Leu Lys Ile Pro Gln 
        275                 280                 285             


Val Ser Leu Gln Phe Ala Gly Ser Gly Asn Leu Thr Leu Thr Leu Asp 
    290                 295                 300                 


Lys Gly Thr Leu His Gln Glu Val Asn Leu Val Val Met Lys Val Ala 
305                 310                 315                 320 


Gln Leu Asn Asn Thr Leu Thr Cys Glu Val Met Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Met Arg Leu Thr Leu Lys Gln Glu Asn Gln Glu Ala Arg Val Ser 
            340                 345                 350         


Glu Glu Gln Lys Val Val Gln Val Val Ala Pro Glu Thr Gly Leu Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Glu Gly Asp Lys Val Lys Met Asp Ser Arg Ile 
    370                 375                 380                 


Gln Val Leu Ser Arg Gly Val Asn Gln Thr Val Phe Leu Ala Cys Val 
385                 390                 395                 400 


Leu Gly Gly Ser Phe Gly Phe Leu Gly Phe Leu Gly Leu Cys Ile Leu 
                405                 410                 415     


Cys Cys Val Arg Cys Arg His Gln Gln Arg Gln Ala Ala Arg Met Ser 
            420                 425                 430         


Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His 
        435                 440                 445             


Arg Met Gln Lys Ser His Asn Leu Ile 
    450                 455         


<210> 79
<211> 458
<212> PRT
<213> Homo sapiens

<400> 79
Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210> 80
<211> 69
<212> PRT
<213> Mus musculus

<400> 80
Lys Ser Met Leu Thr Val Ser Asn Ser Cys Cys Leu Asn Thr Leu Lys 
1               5                   10                  15      


Lys Glu Leu Pro Leu Lys Phe Ile Gln Cys Tyr Arg Lys Met Gly Ser 
            20                  25                  30          


Ser Cys Pro Asp Pro Pro Ala Val Val Phe Arg Leu Asn Lys Gly Arg 
        35                  40                  45              


Glu Ser Cys Ala Ser Thr Asn Lys Thr Trp Val Gln Asn His Leu Lys 
    50                  55                  60                  


Lys Val Asn Pro Cys 
65                  


<210> 81
<211> 73
<212> PRT
<213> Homo sapiens

<400> 81
Lys Ser Met Gln Val Pro Phe Ser Arg Cys Cys Phe Ser Phe Ala Glu 
1               5                   10                  15      


Gln Glu Ile Pro Leu Arg Ala Ile Leu Cys Tyr Arg Asn Thr Ser Ser 
            20                  25                  30          


Ile Cys Ser Asn Glu Gly Leu Ile Phe Lys Leu Lys Arg Gly Lys Glu 
        35                  40                  45              


Ala Cys Ala Leu Asp Thr Val Gly Trp Val Gln Arg His Arg Lys Met 
    50                  55                  60                  


Leu Arg His Cys Pro Ser Lys Arg Lys 
65                  70              


<210> 82
<211> 70
<212> PRT
<213> Mus musculus

<400> 82
Ala Arg Ala Thr Asn Val Gly Arg Glu Cys Cys Leu Asp Tyr Phe Lys 
1               5                   10                  15      


Gly Ala Ile Pro Ile Arg Lys Leu Val Ser Trp Tyr Lys Thr Ser Val 
            20                  25                  30          


Glu Cys Ser Arg Asp Ala Ile Val Phe Leu Thr Val Gln Gly Lys Leu 
        35                  40                  45              


Ile Cys Ala Asp Pro Lys Asp Lys His Val Lys Lys Ala Ile Arg Leu 
    50                  55                  60                  


Val Lys Asn Pro Arg Pro 
65                  70  


<210> 83
<211> 71
<212> PRT
<213> Homo sapiens

<400> 83
Ala Arg Gly Thr Asn Val Gly Arg Glu Cys Cys Leu Glu Tyr Phe Lys 
1               5                   10                  15      


Gly Ala Ile Pro Leu Arg Lys Leu Lys Thr Trp Tyr Gln Thr Ser Glu 
            20                  25                  30          


Asp Cys Ser Arg Asp Ala Ile Val Phe Val Thr Val Gln Gly Arg Ala 
        35                  40                  45              


Ile Cys Ser Asp Pro Asn Asn Lys Arg Val Lys Asn Ala Val Lys Tyr 
    50                  55                  60                  


Leu Gln Ser Leu Glu Arg Ser 
65                  70      


<210> 84
<211> 69
<212> PRT
<213> Homo sapiens

<400> 84
Ala Gln Val Gly Thr Asn Lys Glu Leu Cys Cys Leu Val Tyr Thr Ser 
1               5                   10                  15      


Trp Gln Ile Pro Gln Lys Phe Ile Val Asp Tyr Ser Glu Thr Ser Pro 
            20                  25                  30          


Gln Cys Pro Lys Pro Gly Val Ile Leu Leu Thr Lys Arg Gly Arg Gln 
        35                  40                  45              


Ile Cys Ala Asp Pro Asn Lys Lys Trp Val Gln Lys Tyr Ile Ser Asp 
    50                  55                  60                  


Leu Lys Leu Asn Ala 
65                  


<210> 85
<211> 68
<212> PRT
<213> Mus musculus

<400> 85
Gly Pro Tyr Gly Ala Asn Val Glu Asp Ser Ile Cys Cys Gln Asp Tyr 
1               5                   10                  15      


Ile Arg His Pro Leu Pro Ser Arg Leu Val Lys Glu Phe Phe Trp Thr 
            20                  25                  30          


Ser Lys Ser Cys Arg Lys Pro Gly Val Val Leu Ile Thr Val Lys Asn 
        35                  40                  45              


Arg Asp Ile Cys Ala Asp Pro Arg Gln Val Trp Val Lys Lys Leu Leu 
    50                  55                  60                  


His Lys Leu Ser 
65              


<210> 86
<211> 69
<212> PRT
<213> Homo sapiens

<400> 86
Gly Pro Tyr Gly Ala Asn Met Glu Asp Ser Val Cys Cys Arg Asp Tyr 
1               5                   10                  15      


Val Arg Tyr Arg Leu Pro Leu Arg Val Val Lys His Phe Tyr Trp Thr 
            20                  25                  30          


Ser Asp Ser Cys Pro Arg Pro Gly Val Val Leu Leu Thr Phe Arg Asp 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Arg Val Pro Trp Val Lys Met Ile Leu 
    50                  55                  60                  


Asn Lys Leu Ser Gln 
65                  


<210> 87
<211> 162
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Ser Met Leu Thr 
            20                  25                  30          


Val Ser Asn Ser Cys Cys Leu Asn Thr Leu Lys Lys Glu Leu Pro Leu 
        35                  40                  45              


Lys Phe Ile Gln Cys Tyr Arg Lys Met Gly Ser Ser Cys Pro Asp Pro 
    50                  55                  60                  


Pro Ala Val Val Phe Arg Leu Asn Lys Gly Arg Glu Ser Cys Ala Ser 
65                  70                  75                  80  


Thr Asn Lys Thr Trp Val Gln Asn His Leu Lys Lys Val Asn Pro Cys 
                85                  90                  95      


Ser Gly Gly Gly Gly Ser Asp Pro Glu Phe Thr Asp Tyr Lys Asp Asp 
            100                 105                 110         


Asp Asp Lys Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr 
        115                 120                 125             


Ala Leu Arg Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu 
    130                 135                 140                 


Glu Asn Glu Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly 
145                 150                 155                 160 


Gly Lys 
        


<210> 88
<211> 486
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 88
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc taagagcatg cttacggtct ccaatagctg ctgcttgaac      120

accttgaaga aagagcttcc cctgaagttt atccagtgtt acagaaagat gggctcctcc      180

tgtcctgatc ccccagctgt ggtattcagg ctgaacaaag gtagagaaag ctgcgcctca      240

actaacaaaa cgtgggttca aaatcacctg aagaaggtga acccctgcag cggcgggggt      300

ggcagcgacc ccgaattcac cgattacaag gacgacgatg acaagctgga gatccgcgct      360

gcatttttgc gacaaagaaa taccgctttg cgaaccgaag tggccgagtt ggagcaggaa      420

gtacaacgcc tggaaaatga agtcagccaa tacgaaactc gatatggacc tctcggaggt      480

ggaaag                                                                 486


<210> 89
<211> 163
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Ala Arg Ala Thr Asn 
            20                  25                  30          


Val Gly Arg Glu Cys Cys Leu Asp Tyr Phe Lys Gly Ala Ile Pro Ile 
        35                  40                  45              


Arg Lys Leu Val Ser Trp Tyr Lys Thr Ser Val Glu Cys Ser Arg Asp 
    50                  55                  60                  


Ala Ile Val Phe Leu Thr Val Gln Gly Lys Leu Ile Cys Ala Asp Pro 
65                  70                  75                  80  


Lys Asp Lys His Val Lys Lys Ala Ile Arg Leu Val Lys Asn Pro Arg 
                85                  90                  95      


Pro Ser Gly Gly Gly Gly Ser Asp Pro Glu Phe Thr Asp Tyr Lys Asp 
            100                 105                 110         


Asp Asp Asp Lys Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn 
        115                 120                 125             


Thr Ala Leu Arg Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg 
    130                 135                 140                 


Leu Glu Asn Glu Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly 
145                 150                 155                 160 


Gly Gly Lys 
            


<210> 90
<211> 489
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 90
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc cgcccgagcc accaatgtag gccgagagtg ctgcctggat      120

tacttcaaag gggccattcc tatcaggaag ttggtgagct ggtataagac ctcagtggag      180

tgttccaggg atgccatcgt gtttctgact gtccagggca agctcatctg tgcagacccc      240

aaagacaaac atgtgaagaa ggccatcaga ttggtgaaaa acccaaggcc aagcggcggg      300

ggtggcagcg accccgaatt caccgattac aaggacgacg atgacaagct ggagatccgc      360

gctgcatttt tgcgacaaag aaataccgct ttgcgaaccg aagtggccga gttggagcag      420

gaagtacaac gcctggaaaa tgaagtcagc caatacgaaa ctcgatatgg acctctcgga      480

ggtggaaag                                                              489


<210> 91
<211> 161
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Gly Pro Tyr Gly Ala 
            20                  25                  30          


Asn Val Glu Asp Ser Ile Cys Cys Gln Asp Tyr Ile Arg His Pro Leu 
        35                  40                  45              


Pro Ser Arg Leu Val Lys Glu Phe Phe Trp Thr Ser Lys Ser Cys Arg 
    50                  55                  60                  


Lys Pro Gly Val Val Leu Ile Thr Val Lys Asn Arg Asp Ile Cys Ala 
65                  70                  75                  80  


Asp Pro Arg Gln Val Trp Val Lys Lys Leu Leu His Lys Leu Ser Ser 
                85                  90                  95      


Gly Gly Gly Gly Ser Asp Pro Glu Phe Thr Asp Tyr Lys Asp Asp Asp 
            100                 105                 110         


Asp Lys Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala 
        115                 120                 125             


Leu Arg Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu 
    130                 135                 140                 


Asn Glu Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly 
145                 150                 155                 160 


Lys 
    


<210> 92
<211> 483
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 92
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc cggtccctat ggtgccaatg tggaagacag tatctgctgc      120

caggactaca tccgtcaccc tctgccatca cgtttagtga aggagttctt ctggacctca      180

aaatcctgcc gcaagcctgg cgttgttttg ataaccgtca agaaccgaga tatctgtgcc      240

gatcccaggc aggtctgggt gaagaagcta ctccataaac tgtccagcgg cgggggtggc      300

agcgaccccg aattcaccga ttacaaggac gacgatgaca agctggagat ccgcgctgca      360

tttttgcgac aaagaaatac cgctttgcga accgaagtgg ccgagttgga gcaggaagta      420

caacgcctgg aaaatgaagt cagccaatac gaaactcgat atggacctct cggaggtgga      480

aag                                                                    483


<210> 93
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 93
Ser Gly Gly Gly Gly Ser Asp Pro Glu Phe Thr 
1               5                   10      


<210> 94
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 94
Ala Ala Ala Ser Gly Ser Leu 
1               5           


<210> 95
<211> 111
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Thy1.1 molecule sequence

<400> 95
Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln Ser Leu Arg 
1               5                   10                  15      


Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile Gln Tyr Glu 
            20                  25                  30          


Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe Gly Thr Val 
        35                  40                  45              


Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe Thr Ser Lys 
    50                  55                  60                  


Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser Lys Asp Glu 
65                  70                  75                  80  


Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser Pro Pro Ile 
                85                  90                  95      


Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val Lys Cys 
            100                 105                 110     


<210> 96
<211> 312
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      EGFRt sequence

<400> 96
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser 
305                 310         


<210> 97
<211> 255
<212> PRT
<213> Homo sapiens

<400> 97
Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210> 98
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CD28 sequence

<400> 98
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


