                         SEQUENCE LISTING

<110>  The Johns Hopkins University
 
<120>  COMPOSITIONS AND METHODS FOR DETECTING AUTOANTIBODIES

<130>  P15820-02

<150>  62/719,016
<151>  2018-08-16

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAB12 heavy chain

<400>  1
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcaga tccagttggt gcagtctgga cctgagctga agaagcctgg agagacagtc      120

aagatctcct gcaaggcttc tgggtatacc ttcacaaact atccaatgca ctgggtgaag      180

cagactccag gaaagggttt aaagtggatg ggctggataa acacctactc tggagtgcca      240

acatatggag atgacttcaa gggacggttt gccttctctt tggaaacctc tgccagtact      300

gcatatttgc agatcaacaa cctcaaaaat gaagacatgg ctacatattt ctgtgcaaga      360

tcgaacccct atgattactt gtatgctatg gactcctggg gtcaaggaac ctcagtcacc      420

gtctctagtg ccaaaacgac acccccatct gtctacccac tggcccctgg atctgctgcc      480

caaactaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgagccagtg      540

acagtgacct ggaactctgg atccctgtcc agcggtgtgc acaccttccc agctgtcctg      600

cagtctgacc tctacactct gagcagctca gtgactgtcc cctccagcac ctggcccagc      660

gagaccgtca cctgcaacgt tgcccacccg gccagcagca ccaaggtgga caagaaaatt      720

gtgcccaggg attgtggttg taagccttgc atatgtacag tcccagaagt atcatctgtc      780

ttcatcttcc ccccaaagcc caaggatgtg ctcaccatta ctctgactcc taaggtcacg      840

tgtgttgtgg tagacatcag caaggatgat cccgaggtcc agttcagctg gtttgtagat      900

gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa cagcactttc      960

cgctcagtca gtgaacttcc catcatgcac caggactggc tcaatggcaa ggagttcaaa     1020

tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc caaaaccaaa     1080

ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca gatggccaag     1140

gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat tactgtggag     1200

tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat catggacaca     1260

gatggctctt acttcgtcta cagcaagctc aatgtgcaga agagcaactg ggaggcagga     1320

aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac tgagaagagc     1380

ctctcccact ctcctggtaa atga                                            1404


<210>  2
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB12 heavy chain

<400>  2

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asn Tyr Pro Met His Trp Val Lys Gln Thr Pro Gly 
    50                  55                  60                  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Thr Tyr Gly Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Met Ala Thr Tyr Phe Cys Ala Arg Ser Asn Pro Tyr Asp Tyr Leu Tyr 
        115                 120                 125             


Ala Met Asp Ser Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala 
145                 150                 155                 160 


Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 
        195                 200                 205             


Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr 
    210                 215                 220                 


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
225                 230                 235                 240 


Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
                245                 250                 255     


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            260                 265                 270         


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        275                 280                 285             


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    290                 295                 300                 


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        355                 360                 365             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    370                 375                 380                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
385                 390                 395                 400 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                405                 410                 415     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            420                 425                 430         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        435                 440                 445             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb12 heavy chain CDR1

<400>  3

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb12 heavy chain CDR2

<400>  4

Thr Tyr Ser Gly Val 
1               5   


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB heavy chain CDR3

<400>  5

Ser Asn Pro Tyr Asp Tyr Leu Tyr Ala Met Asp Ser 
1               5                   10          


<210>  6
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb12 light chain

<400>  6
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgatg ttgtgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa      120

gcctccatct cctgcagatc tagtcagagc cttgtacaca tcaatggaaa cacctatata      180

cattggtacc tgcagaagcc aggccagtct ccaaagctcc tgatctacaa agtttccaac      240

cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga ttttacactc      300

aagatcagaa gagtggaggc tgaggatctg ggagtttatt tctgctctca aaatacacat      360

gttccattca cattcggctc ggggacaaag ttggaaataa aacgtgcaga tgctgcgcca      420

actgtatcca tcttcccacc atctagcgag cagttaacat ctggaggtgc ctcagtcgtg      480

tgcttcttga acaacttcta ccccaaagac atcaatgtca agtggaagat tgatggcagt      540

gaacgacaaa atggcgtcct gaacagttgg actgatcagg acagcaaaga cagcacctac      600

agcatgagca gcaccctcac gttgaccaag gacgagtatg aacgacataa cagctatacc      660

tgtgaggcca ctcacaagac atcaacttca cccattgtca agagcttcaa caggaatgag      720

tgttag                                                                 726


<210>  7
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb12 light chain

<400>  7

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Val Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Val His Ile Asn Gly Asn Thr Tyr Ile His Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Arg Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Phe Cys Ser Gln Asn Thr His Val Pro Phe Thr Phe Gly Ser Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val 
145                 150                 155                 160 


Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys 
                165                 170                 175     


Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr 
    210                 215                 220                 


His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu 
225                 230                 235                 240 


Cys 
    


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb12 light chain CDR1

<400>  8

Arg Ser Ser Gln Ser Leu Val His Ile Asn Gly Asn Thr Tyr Ile His 
1               5                   10                  15      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb12 light chain CDR2

<400>  9

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb12 light chain CDR3

<400>  10

Ser Gln Asn Thr His Val Pro Phe Thr 
1               5                   


<210>  11
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain

<400>  11
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcaga tccagttggt gcagtctgga cctgagctga agaagcctgg agagacagtc      120

acgatctcct gcaaggcttc tggatatacc ttcacacact atccagtgca ctgggtgaag      180

caggctccag gaaagggttt acagtggatg ggctggataa acacctactc tggagtgcca      240

acatatgcag atgccttcaa gaaacgtttt gccttctctt tggaaacctc tgccagcact      300

gcatatttgc agatcaacaa cctcaaaagt gaggacatgg ctacatattt ctgtgcaaga      360

tcgagggtct atgatgggta ctattttgac tactggggcc aaggcaccac tctcaccgtc      420

tctagtgcca aaacgacacc cccatctgtc tacccactgg cccctggatc tgctgcccaa      480

actaactcca tggtgaccct gggatgcctg gtcaagggct atttccctga gccagtgaca      540

gtgacctgga actctggatc cctgtccagc ggtgtgcaca ccttcccagc tgtcctgcag      600

tctgacctct acactctgag cagctcagtg actgtcccct ccagcacctg gcccagcgag      660

accgtcacct gcaacgttgc ccacccggcc agcagcacca aggtggacaa gaaaattgtg      720

cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc      780

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt      840

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat      900

gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc      960

tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc     1020

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc     1080

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat     1140

aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg     1200

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat     1260

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat     1320

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc     1380

tcccactctc ctggtaaatg a                                               1401


<210>  12
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain

<400>  12

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Thr Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr His Tyr Pro Val His Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Gln Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Thr Tyr Ala Asp Ala Phe Lys Lys Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp 
            100                 105                 110         


Met Ala Thr Tyr Phe Cys Ala Arg Ser Arg Val Tyr Asp Gly Tyr Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys 
    130                 135                 140                 


Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln 
145                 150                 155                 160 


Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser 
        195                 200                 205             


Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys 
    210                 215                 220                 


Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val 
225                 230                 235                 240 


Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
                245                 250                 255     


Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
            260                 265                 270         


Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
    290                 295                 300                 


Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 
        355                 360                 365             


Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 
    370                 375                 380                 


Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp 
385                 390                 395                 400 


Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile 
                405                 410                 415     


Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 
            420                 425                 430         


Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 
        435                 440                 445             


Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain CDR1

<400>  13

Gly Tyr Thr Phe Thr His Tyr 
1               5           


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain CDR2

<400>  14

Asn Thr Tyr Ser Gly Val 
1               5       


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 heavy chain CDR3

<400>  15

Ser Arg Val Tyr Asp Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  16
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain

<400>  16
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgatg ttgtgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa      120

gcctccatct cttgcagatc tagtcagagc cttgtacaca gtaatggaaa gacctattta      180

cattggtacc tgcagaagcc aggccagtct ccaaacctcc tgatctacaa agtttccaac      240

cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc      300

aagatcagca gagtggaggc tgaggatctg ggagtttatt tctgctctca acttacacat      360

gttccgtgga cgttcggtgg aggcaccaag ctggaaatca aacgtgcaga tgctgcgcca      420

actgtatcca tcttcccacc atctagcgag cagttaacat ctggaggtgc ctcagtcgtg      480

tgcttcttga acaacttcta ccccaaagac atcaatgtca agtggaagat tgatggcagt      540

gaacgacaaa atggcgtcct gaacagttgg actgatcagg acagcaaaga cagcacctac      600

agcatgagca gcaccctcac gttgaccaag gacgagtatg aacgacataa cagctatacc      660

tgtgaggcca ctcacaagac atcaacttca cccattgtca agagcttcaa caggaatgag      720

tgttag                                                                 726


<210>  17
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain

<400>  17

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Val Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Val His Ser Asn Gly Lys Thr Tyr Leu His Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Phe Cys Ser Gln Leu Thr His Val Pro Trp Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val 
145                 150                 155                 160 


Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys 
                165                 170                 175     


Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr 
    210                 215                 220                 


His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu 
225                 230                 235                 240 


Cys 
    


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain CDR1

<400>  18

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Lys Thr Tyr Leu His 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain CDR2

<400>  19

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb16 light chain CDR3

<400>  20

Ser Gln Leu Thr His Val Pro Trp 
1               5               


<210>  21
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb17 heavy chain

<400>  21
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcaga tccagttggt gcagtctgga cctgagctga agaagcctgg agagacagtc      120

aagatctcct gcaaggcttc tgggtatacc ttcacaaact atccaatgca ctggttgaag      180

caggctccag gaaagggttt aaagtggatg ggctggataa acacctactc tggagtgcca      240

acatatgcag atgacttcaa gggacggttt gccttctctt tggaaacctc tgccagcact      300

gcatatttgc agatcaacaa cctcaaaaat gaggacatgg ctacatattt ctgtacaaaa      360

tcgcgcatta ctacgatggg gggttatgct atggactgct ggggtcaagg aacctcagtc      420

accgtctcta gtgccaaaac gacaccccca tctgtctacc cactggcccc tggatctgct      480

gcccaaacta actccatggt gaccctggga tgcctggtca agggctattt ccctgagcca      540

gtgacagtga cctggaactc tggatccctg tccagcggtg tgcacacctt cccagctgtc      600

ctgcagtctg acctctacac tctgagcagc tcagtgactg tcccctccag cacctggccc      660

agcgagaccg tcacctgcaa cgttgcccac ccggccagca gcaccaaggt ggacaagaaa      720

attgtgccca gggattgtgg ttgtaagcct tgcatatgta cagtcccaga agtatcatct      780

gtcttcatct tccccccaaa gcccaaggat gtgctcacca ttactctgac tcctaaggtc      840

acgtgtgttg tggtagacat cagcaaggat gatcccgagg tccagttcag ctggtttgta      900

gatgatgtgg aggtgcacac agctcagacg caaccccggg aggagcagtt caacagcact      960

ttccgctcag tcagtgaact tcccatcatg caccaggact ggctcaatgg caaggagttc     1020

aaatgcaggg tcaacagtgc agctttccct gcccccatcg agaaaaccat ctccaaaacc     1080

aaaggcagac cgaaggctcc acaggtgtac accattccac ctcccaagga gcagatggcc     1140

aaggataaag tcagtctgac ctgcatgata acagacttct tccctgaaga cattactgtg     1200

gagtggcagt ggaatgggca gccagcggag aactacaaga acactcagcc catcatggac     1260

acagatggct cttacttcgt ctacagcaag ctcaatgtgc agaagagcaa ctgggaggca     1320

ggaaatactt tcacctgctc tgtgttacat gagggcctgc acaaccacca tactgagaag     1380

agcctctccc actctcctgg taaatga                                         1407


<210>  22
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb17 heavy chain

<400>  22

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asn Tyr Pro Met His Trp Leu Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Met Ala Thr Tyr Phe Cys Thr Lys Ser Arg Ile Thr Thr Met Gly Gly 
        115                 120                 125             


Tyr Ala Met Asp Cys Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
145                 150                 155                 160 


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
        195                 200                 205             


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
    210                 215                 220                 


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
                245                 250                 255     


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
            260                 265                 270         


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
        275                 280                 285             


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
    290                 295                 300                 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
        355                 360                 365             


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
    370                 375                 380                 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
385                 390                 395                 400 


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
                405                 410                 415     


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
            420                 425                 430         


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
        435                 440                 445             


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb17 heavy chain CDR1

<400>  23

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb17 heavy chain CDR2

<400>  24

Asn Thr Tyr Ser Gly Val 
1               5       


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb17 heavy chain CDR3

<400>  25

Ser Arg Ile Thr Thr Met Gly Gly Tyr Ala Met Asp Cys 
1               5                   10              


<210>  26
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb17 light chain

<400>  26
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaag ttgtgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa      120

gcctccatct cttgcagatc tagtcagagc cttctacaca gtaatggaaa cacctattta      180

cattggtacc tgcagaggcc aggccagtct ccaaacctcc tgatctccaa agtttccaac      240

cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc      300

aagatcagca gagtggaggc tgaggatctg ggagtttatt tctgctctca aaatacacat      360

gttccgtgga cgttcggtgg aggcaccaag ctggaaatca aacgtgcaga tgctgcgcca      420

actgtatcca tcttcccacc atctagcgag cagttaacat ctggaggtgc ctcagtcgtg      480

tgcttcttga acaacttcta ccccaaagac atcaatgtca agtggaagat tgatggcagt      540

gaacgacaaa atggcgtcct gaacagttgg actgatcagg acagcaaaga cagcacctac      600

agcatgagca gcaccctcac gttgaccaag gacgagtatg aacgacataa cagctatacc      660

tgtgaggcca ctcacaagac atcaacttca cccattgtca agagcttcaa caggaatgag      720

tgttag                                                                 726


<210>  27
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb17 light chain

<400>  27

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Val Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
    50                  55                  60                  


Gln Arg Pro Gly Gln Ser Pro Asn Leu Leu Ile Ser Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Phe Cys Ser Gln Asn Thr His Val Pro Trp Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val 
145                 150                 155                 160 


Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys 
                165                 170                 175     


Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr 
    210                 215                 220                 


His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu 
225                 230                 235                 240 


Cys 
    


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb17 light chain CDR1

<400>  28

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb17 light chain CDR2

<400>  29

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb17 light chain CDR3

<400>  30

Ser Gln Asn Thr His Val Pro Trp Thr 
1               5                   


<210>  31
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb20 heavy chain

<400>  31
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcaga tccagttggt gcagtctgga cctgagctga agaagcctgg agagacagtc      120

aagatctcct gcaaggcttc tgggtatatc ttcacaaact atccaatgca ctgggtgaag      180

caggctccag gaaagggttt aaagtggatg ggctggataa acacctactc tggagtgcca      240

acacatgcag atgacttcaa gggacggttt gccttctctt tggaaacctc tgccaacagt      300

gcatttttgc agatcaacaa cctcaaaaat gaggacacgg ctacatattt ctgtacaaga      360

tcgcgcatta ctccgacggg gggctatgct atggactact ggggtcaagg aacctcagtc      420

accgtctcta gtgccaaaac gacaccccca tctgtctacc cactggcccc tggatctgct      480

gcccaaacta actccatggt gaccctggga tgcctggtca agggctattt ccctgagcca      540

gtgacagtga cctggaactc tggatccctg tccagcggtg tgcacacctt cccagctgtc      600

ctgcagtctg acctctacac tctgagcagc tcagtgactg tcccctccag cacctggccc      660

agcgagaccg tcacctgcaa cgttgcccac ccggccagca gcaccaaggt ggacaagaaa      720

attgtgccca gggattgtgg ttgtaagcct tgcatatgta cagtcccaga agtatcatct      780

gtcttcatct tccccccaaa gcccaaggat gtgctcacca ttactctgac tcctaaggtc      840

acgtgtgttg tggtagacat cagcaaggat gatcccgagg tccagttcag ctggtttgta      900

gatgatgtgg aggtgcacac agctcagacg caaccccggg aggagcagtt caacagcact      960

ttccgctcag tcagtgaact tcccatcatg caccaggact ggctcaatgg caaggagttc     1020

aaatgcaggg tcaacagtgc agctttccct gcccccatcg agaaaaccat ctccaaaacc     1080

aaaggcagac cgaaggctcc acaggtgtac accattccac ctcccaagga gcagatggcc     1140

aaggataaag tcagtctgac ctgcatgata acagacttct tccctgaaga cattactgtg     1200

gagtggcagt ggaatgggca gccagcggag aactacaaga acactcagcc catcatggac     1260

acagatggct cttacttcgt ctacagcaag ctcaatgtgc agaagagcaa ctgggaggca     1320

ggaaatactt tcacctgctc tgtgttacat gagggcctgc acaaccacca tactgagaag     1380

agcctctccc actctcctgg taaatga                                         1407


<210>  32
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb20 heavy chain

<400>  32

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Ile Phe Thr Asn Tyr Pro Met His Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Thr His Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Asn Ser Ala Phe Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Thr Ala Thr Tyr Phe Cys Thr Arg Ser Arg Ile Thr Pro Thr Gly Gly 
        115                 120                 125             


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
145                 150                 155                 160 


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
        195                 200                 205             


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
    210                 215                 220                 


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
                245                 250                 255     


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
            260                 265                 270         


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
        275                 280                 285             


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
    290                 295                 300                 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
        355                 360                 365             


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
    370                 375                 380                 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
385                 390                 395                 400 


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
                405                 410                 415     


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
            420                 425                 430         


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
        435                 440                 445             


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb20 heavy chain CDR1

<400>  33

Gly Tyr Ile Phe Thr Asn Tyr 
1               5           


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb20 heavy chain CDR2

<400>  34

Asn Thr Tyr Ser Gly Val 
1               5       


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb20 heavy chain CDR3

<400>  35

Ser Arg Ile Thr Pro Thr Gly Gly Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  36
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb20 light chain

<400>  36
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgatg ttgtgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa      120

gcctccatct cttgcagatc tagtcagagc cttgtacaca gtaatggaaa cacctattta      180

cattggtacc tgcagaagcc aggccagtct ccaaacctcc tgatctccaa agtttccaac      240

cgattttctg gggtcccaga aaggttcagt ggcagtggat cagggacaga tttcacactc      300

aagatcagca gagtggaggc tgaggatctg ggagtttatt tctgctctca aaatacacat      360

gttccgtgga cgttcggtgg aggcaccaag ctggaaatca aacgtgcaga tgctgcgcca      420

actgtatcca tcttcccacc atctagcgag cagttaacat ctggaggtgc ctcagtcgtg      480

tgcttcttga acaacttcta ccccaaagac atcaatgtca agtggaagat tgatggcagt      540

gaacgacaaa atggcgtcct gaacagttgg actgatcagg acagcaaaga cagcacctac      600

agcatgagca gcaccctcac gttgaccaag gacgagtatg aacgacataa cagctatacc      660

tgtgaggcca ctcacaagac atcaacttca cccattgtca agagcttcaa caggaatgag      720

tgttag                                                                 726


<210>  37
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb20 light chain

<400>  37

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Val Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Asn Leu Leu Ile Ser Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Phe Cys Ser Gln Asn Thr His Val Pro Trp Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val 
145                 150                 155                 160 


Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys 
                165                 170                 175     


Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr 
    210                 215                 220                 


His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu 
225                 230                 235                 240 


Cys 
    


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb20 light chain CDR1

<400>  38

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb20 light chain CDR2

<400>  39

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb40 light chain CDR3

<400>  40

Ser Gln Asn Thr His Val Pro Trp Thr 
1               5                   


<210>  41
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb28 heavy chain

<400>  41
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcaga tccagttggt gcagtctgga cctgagctga agaagcctgg agagacagtc      120

aagatctcct gcaaggcttc tgggtatacc ttcacaaact atccaatgca ctgggtaaag      180

caggctccag gaaaggattt aaagtggatg ggctggataa acacctactc tggaatgtca      240

acatatgcag atgacttcaa gggacggttt gccttctctt tggaaacctc tgccagcact      300

gcgtatttgc agatcaacaa cctcaaaaat gaggacatgg ctacatattt ctgtgcaaga      360

tcgcgcatta caacgatggg gggctatgct atggactact ggggtcaagg agcctcagtc      420

accgtctcta gtgccaaaac gacaccccca tctgtctacc cactggcccc tggatctgct      480

gcccaaacta actccatggt gaccctggga tgcctggtca agggctattt ccctgagcca      540

gtgacagtga cctggaactc tggatccctg tccagcggtg tgcacacctt cccagctgtc      600

ctgcagtctg acctctacac tctgagcagc tcagtgactg tcccctccag cacctggccc      660

agcgagaccg tcacctgcaa cgttgcccac ccggccagca gcaccaaggt ggacaagaaa      720

attgtgccca gggattgtgg ttgtaagcct tgcatatgta cagtcccaga agtatcatct      780

gtcttcatct tccccccaaa gcccaaggat gtgctcacca ttactctgac tcctaaggtc      840

acgtgtgttg tggtagacat cagcaaggat gatcccgagg tccagttcag ctggtttgta      900

gatgatgtgg aggtgcacac agctcagacg caaccccggg aggagcagtt caacagcact      960

ttccgctcag tcagtgaact tcccatcatg caccaggact ggctcaatgg caaggagttc     1020

aaatgcaggg tcaacagtgc agctttccct gcccccatcg agaaaaccat ctccaaaacc     1080

aaaggcagac cgaaggctcc acaggtgtac accattccac ctcccaagga gcagatggcc     1140

aaggataaag tcagtctgac ctgcatgata acagacttct tccctgaaga cattactgtg     1200

gagtggcagt ggaatgggca gccagcggag aactacaaga acactcagcc catcatggac     1260

acagatggct cttacttcgt ctacagcaag ctcaatgtgc agaagagcaa ctgggaggca     1320

ggaaatactt tcacctgctc tgtgttacat gagggcctgc acaaccacca tactgagaag     1380

agcctctccc actctcctgg taaatga                                         1407


<210>  42
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb28 heavy chain

<400>  42

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asn Tyr Pro Met His Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Asp Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Met Ser 
65                  70                  75                  80  


Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Met Ala Thr Tyr Phe Cys Ala Arg Ser Arg Ile Thr Thr Met Gly Gly 
        115                 120                 125             


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
145                 150                 155                 160 


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
        195                 200                 205             


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
    210                 215                 220                 


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
                245                 250                 255     


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
            260                 265                 270         


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
        275                 280                 285             


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
    290                 295                 300                 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
        355                 360                 365             


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
    370                 375                 380                 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
385                 390                 395                 400 


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
                405                 410                 415     


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
            420                 425                 430         


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
        435                 440                 445             


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb28 heavy chain CDR1

<400>  43

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb28 heavy chain CDR2

<400>  44

Asn Thr Tyr Ser Gly Met 
1               5       


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb28 heavy chain CDR3

<400>  45

Ser Arg Ile Thr Thr Met Gly Gly Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  46
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb28 light chain

<400>  46
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtgaag ttgtgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa      120

gcctccatct cttgcagatc tagtcagagc cttgtacaca gtaatggaaa cacctattta      180

cattggtacc tgcagaagcc aggccagtct ccaaagctcc tgatctccaa agtttccaac      240

cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc      300

aagatcatca gagtggaggc tgaggatctg ggagtttatt tctgctctca aaatacacat      360

gttccgtgga cgttcggtgg aggcaccaag ctggaaatca aacgtgcaga tgctgcgcca      420

actgtatcca tcttcccacc atctagcgag cagttaacat ctggaggtgc ctcagtcgtg      480

tgcttcttga acaacttcta ccccaaagac atcaatgtca agtggaagat tgatggcagt      540

gaacgacaaa atggcgtcct gaacagttgg actgatcagg acagcaaaga cagcacctac      600

agcatgagca gcaccctcac gttgaccaag gacgagtatg aacgacataa cagctatacc      660

tgtgaggcca ctcacaagac atcaacttca cccattgtca agagcttcaa caggaatgag      720

tgttag                                                                 726


<210>  47
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb28 light chain

<400>  47

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Val Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Ser Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ile Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Phe Cys Ser Gln Asn Thr His Val Pro Trp Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val 
145                 150                 155                 160 


Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys 
                165                 170                 175     


Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr 
    210                 215                 220                 


His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu 
225                 230                 235                 240 


Cys 
    


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb28 light chain CDR1

<400>  48

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb28 light chain CDR2

<400>  49

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb28 light chain CDR3

<400>  50

Ser Gln Asn Thr His Val Pro Trp Thr 
1               5                   


<210>  51
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb39 heavy chain

<400>  51
atgggatgga gctgtatcat gttctttttg gtagcaacag ctacagatgt ccactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggctactc cttcaccacc tactggatgc actgggtgaa gcagaggcct      180

ggacaaggcc tagagtgggt tggagatatt aatcctagga acggtcgtac taactacaat      240

gagaagtcca agagcaaggc cacactgact gtagacatat catccagcac agtatacatg      300

caagtcagca gcctgacatc tgaggactct gcggtctatt actgtgcaat atggtcgggt      360

gctatggact actggggtcc aggaacctca gtcaccgtct cctcagccaa aacaacagcc      420

ccatcggtct atccactggc ccctgtgtgt ggagatacaa ctggctcctc ggtgactcta      480

ggatgcctgg tcaagggtta tttccctgag ccagtgacct tgacctggaa ctctggatcc      540

ctgtccagtg atgtgcacac cttcccagct ctcctgcagt ctggcctcta caccctcagc      600

agctcagtga ctgtaaccac ctggcccagc cagaccatca cctgcaatgt ggcccacccg      660

gcaagcagca ccaaagtgga caagaaaatt gagcccagag ggtccccaac acataaaccc      720

tgtcctccat gcccagctcc taacctcttg ggtggaccat ccgtcttcat cttccctcca      780

aagatcaagg atgtactcat gatctccctg agccccatgg tcacgtgtgt ggtggtggat      840

gtgagcgagg atgacccaga tgtccatgtc agctggttcg tgaacaacgt ggaagtacac      900

acagctcaga cacaaaccca tagagaggat tacaacagta ctatccgggt ggtcagtgcc      960

ctccccatcc agcaccagga ctggatgagt ggcaaggagt tcaaatgcaa ggtcaacaac     1020

aaagccctcc cagcgcccat cgagagaacc atctcaaaac ccaaagggcc agtaagagct     1080

ccacaggtat atgtcttgcc tccaccagaa gaagagatga ctaagaaaca ggtcactctg     1140

acctgcatga tcacagactt catgcctgaa gacatttacg tggagtggac caacaacggg     1200

caaacagagc taaactacaa gaacactgaa ccagtcctgg actctgatgg ttcttacttc     1260

atgtacagca agctgagagt ggaaaagaag aactgggtgg aaagaaatag ctactcctgt     1320

tcagtggtcc acgagggtct gcacaatcac cacacgacta agagcttctc ccggtctccg     1380

ggtaaatga                                                             1389


<210>  52
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb39 heavy chain

<400>  52

Met Gly Trp Ser Cys Ile Met Phe Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Thr Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Asp Ile Asn Pro Arg Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Ser Lys Ser Lys Ala Thr Leu Thr Val Asp Ile Ser Ser Ser 
                85                  90                  95      


Thr Val Tyr Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ile Trp Ser Gly Ala Met Asp Tyr Trp Gly Pro Gly 
        115                 120                 125             


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Ser Ser Asp Val His Thr Phe Pro Ala Leu Leu 
            180                 185                 190         


Gln Ser Gly Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Thr Trp 
        195                 200                 205             


Pro Ser Gln Thr Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Ser Pro Thr His Lys Pro 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
            260                 265                 270         


Met Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
        275                 280                 285             


His Val Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Ala 
305                 310                 315                 320 


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Lys Val Asn Asn Lys Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
            340                 345                 350         


Lys Pro Lys Gly Pro Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
        355                 360                 365             


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Ile 
    370                 375                 380                 


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
385                 390                 395                 400 


Gln Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
            420                 425                 430         


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Thr Lys Ser Phe Ser Arg Ser Pro Gly Lys 
    450                 455                 460         


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb39 heavy chain CDR1

<400>  53

Gly Tyr Ser Phe Thr Thr Tyr 
1               5           


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb39 heavy chain CDR2

<400>  54

Asn Pro Arg Asn Gly Arg 
1               5       


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb39 heavy chain CDR3

<400>  55

Trp Ser Gly Ala Met Asp Tyr 
1               5           


<210>  56
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb39 light chain

<400>  56
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca accctccatc      120

tcttgcaaat ctagtcagag ccttgtacac aataatggaa acacctattt acattggtac      180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaactacaca tgttcctccg      360

acgttcggtg gaggcaccaa gctggaaatc aaacgggctg atgctgcacc aactgtatcc      420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg      480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      660

actcacaaga catcaacttc acccattgtc aagagcttca acaggggaga gtgttga         717


<210>  57
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb39 light chain

<400>  57

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Pro Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Asn Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Thr Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb39 light chain CDR1

<400>  58

Lys Ser Ser Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb39 light chain CDR2

<400>  59

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb39 light chain CDR3

<400>  60

Ser Gln Thr Thr His Val Pro Pro Thr 
1               5                   


<210>  61
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mAb39 heavy chain v2 (t1375a-->S459T)

<400>  61
atgggatgga gctgtatcat gttctttttg gtagcaacag ctacagatgt ccactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggctactc cttcaccacc tactggatgc actgggtgaa gcagaggcct      180

ggacaaggcc tagagtgggt tggagatatt aatcctagga acggtcgtac taactacaat      240

gagaagtcca agagcaaggc cacactgact gtagacatat catccagcac agtatacatg      300

caagtcagca gcctgacatc tgaggactct gcggtctatt actgtgcaat atggtcgggt      360

gctatggact actggggtcc aggaacctca gtcaccgtct cctcagccaa aacaacagcc      420

ccatcggtct atccactggc ccctgtgtgt ggagatacaa ctggctcctc ggtgactcta      480

ggatgcctgg tcaagggtta tttccctgag ccagtgacct tgacctggaa ctctggatcc      540

ctgtccagtg atgtgcacac cttcccagct ctcctgcagt ctggcctcta caccctcagc      600

agctcagtga ctgtaaccac ctggcccagc cagaccatca cctgcaatgt ggcccacccg      660

gcaagcagca ccaaagtgga caagaaaatt gagcccagag ggtccccaac acataaaccc      720

tgtcctccat gcccagctcc taacctcttg ggtggaccat ccgtcttcat cttccctcca      780

aagatcaagg atgtactcat gatctccctg agccccatgg tcacgtgtgt ggtggtggat      840

gtgagcgagg atgacccaga tgtccatgtc agctggttcg tgaacaacgt ggaagtacac      900

acagctcaga cacaaaccca tagagaggat tacaacagta ctatccgggt ggtcagtgcc      960

ctccccatcc agcaccagga ctggatgagt ggcaaggagt tcaaatgcaa ggtcaacaac     1020

aaagccctcc cagcgcccat cgagagaacc atctcaaaac ccaaagggcc agtaagagct     1080

ccacaggtat atgtcttgcc tccaccagaa gaagagatga ctaagaaaca ggtcactctg     1140

acctgcatga tcacagactt catgcctgaa gacatttacg tggagtggac caacaacggg     1200

caaacagagc taaactacaa gaacactgaa ccagtcctgg actctgatgg ttcttacttc     1260

atgtacagca agctgagagt ggaaaagaag aactgggtgg aaagaaatag ctactcctgt     1320

tcagtggtcc acgagggtct gcacaatcac cacacgacta agagcttctc ccggactccg     1380

ggtaaatga                                                             1389


<210>  62
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb39 heavy chain (S459T)

<400>  62

Met Gly Trp Ser Cys Ile Met Phe Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Thr Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Asp Ile Asn Pro Arg Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Ser Lys Ser Lys Ala Thr Leu Thr Val Asp Ile Ser Ser Ser 
                85                  90                  95      


Thr Val Tyr Met Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ile Trp Ser Gly Ala Met Asp Tyr Trp Gly Pro Gly 
        115                 120                 125             


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Ser Ser Asp Val His Thr Phe Pro Ala Leu Leu 
            180                 185                 190         


Gln Ser Gly Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Thr Trp 
        195                 200                 205             


Pro Ser Gln Thr Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Ser Pro Thr His Lys Pro 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
            260                 265                 270         


Met Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
        275                 280                 285             


His Val Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Ala 
305                 310                 315                 320 


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Lys Val Asn Asn Lys Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
            340                 345                 350         


Lys Pro Lys Gly Pro Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
        355                 360                 365             


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Ile 
    370                 375                 380                 


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
385                 390                 395                 400 


Gln Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
            420                 425                 430         


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460         


