                         SEQUENCE LISTING

<110>  NantBio, Inc.
 
<120>  IL7-IL15 TxM COMPOSITIONS AND METHODS

<130>  102719.0014PCT

<150>  US 62/764,875
<151>  2018-08-16

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TxM Construct (IL-7)


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  Leader peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(171)
<223>  IL-7

<220>
<221>  MISC_FEATURE
<222>  (172)..(285)
<223>  IL-15 (N72D)

<400>  1

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
            20                  25                  30          


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
        35                  40                  45              


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
    50                  55                  60                  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
65                  70                  75                  80  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu Glu 
                85                  90                  95      


Ile Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
            100                 105                 110         


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
        115                 120                 125             


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
    130                 135                 140                 


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
145                 150                 155                 160 


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Asn Trp Val Asn Val 
                165                 170                 175     


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
            180                 185                 190         


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
        195                 200                 205             


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
    210                 215                 220                 


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
225                 230                 235                 240 


Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
                245                 250                 255     


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
            260                 265                 270         


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
        275                 280                 285 


<210>  2
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TxM Construct (Il-21)


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  Leader peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(151)
<223>  IL-21

<220>
<221>  MISC_FEATURE
<222>  (152)..(216)
<223>  IL-15 Receptor Sushi Domain

<220>
<221>  MISC_FEATURE
<222>  (217)..(448)
<223>  Human IgG Fc portion

<400>  2

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
            20                  25                  30          


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
        35                  40                  45              


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
    50                  55                  60                  


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
65                  70                  75                  80  


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
                85                  90                  95      


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
            100                 105                 110         


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
        115                 120                 125             


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
    130                 135                 140                 


Thr His Gly Ser Glu Asp Ser Ile Thr Cys Pro Pro Pro Met Ser Val 
145                 150                 155                 160 


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
                165                 170                 175     


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
            180                 185                 190         


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
        195                 200                 205             


Thr Pro Ser Leu Lys Cys Ile Arg Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


