                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> IL-10 INHIBITION FOR VACCINES AND IMMUNOTHERAPY

<130> 070772-226020PC-1146979

<140> PCT/US2019/046503
<141> 2019-08-14

<150> 62/845,671
<151> 2019-05-09

<150> 62/764,848
<151> 2018-08-15

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 178
<212> PRT
<213> Macaca mulatta

<400> 1
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr Arg 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro His Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Ile 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn His Asp Pro Asp Ile Lys Glu His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Ser Lys Leu Gln Glu Lys Gly Val Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Gln Asn 
        


<210> 2
<211> 178
<212> PRT
<213> Homo sapiens

<400> 2
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 3
<211> 1175
<212> DNA
<213> Cercopithecine herpesvirus 8

<400> 3
atgcggagga ggaggaggtc tttcggcatc atcgtcgccg gcgctatcgg aacactactc       60

atgatggcgg tggtcgtgct ttcagcccat gaccatgaac acaaagaagt accaccggcc      120

tgtgaccccg ttcacggtaa cttggcaggc atcttcaagg agttgcgggc gacctacgct      180

tccattagag aaggtttggt atgttaggca acgcagttct cggatgtcag tccggatcgg      240

aggagtcaca gtctgtcatg tgatgatata ttgcttaatt tttgttttgc agcaaaagaa      300

ggacacggtg tactacacat cgctgttcaa tgaccgcgtg ctccatgaaa tgctgagtcc      360

tatgggctgt cgcgtgacca atgaactcat ggaacattat ttagatggtg ttctgcctcg      420

agcaagtcat ttagactacg ataatagcac tctgaatggc ttacatgtgt ttgcttcatc      480

catgcaggcg ctgtatcagc acatgttaaa gtgtgtaagt gtttcaggtt cgataacccc      540

gcgatatgac acgtaaatag cgatatcgtg gcaccagacg tcagtcacag tcttccccgg      600

tcgagacgca tcttatatcg cgatatatcg cggattatcg cagtatgtag cgatatatcg      660

tgtcaaagca ctccgaacga cattctgatg acggctatcg ccttatgtcg cggtatatcg      720

cggaatatcg cagtatatcg cggttatgtc gcgacataac cgtcatgtcg cgactatcgc      780

cgcatatcgc cactatcgcg acttggcacc gtgccaacga tagtcgacct tagggtggtc      840

gtgtggtggt ggggggctgc ttgcggtttg caaaccggag aggtagcaca cgctgattgt      900

cggtttggaa gcgttgttta cacatgtctt tgtcttggca gcccgcgttg gcatgtactg      960

gcaaaacgcc agcttggatg tacttcttgg aggtggaaca caaggtcagt taaggttgcc     1020

aggtaggtta aaacgcagaa accattgttc taccggtttc ctaaaacgcc gttcaacgtg     1080

ttttgcagct caacccctgg aggggcacgg caaaagccgc ggccgaggct gaccttttgc     1140

tgaactactt ggaaacgttc ctgctgcagt tctga                                1175


<210> 4
<211> 1179
<212> DNA
<213> Cercopithecine herpesvirus 8

<400> 4
atgcggagga ggaggaggtc tttcggcatc atcgtcgccg gcgctatcgg aacactactc       60

atgatggcgg tggtcgtgct ttcagcccat gaacacaaag aagtaccacc ggcctgtgac      120

cccgttcacg gtaacttggc aggcatcttc aaggagttgc gggcgaccta cgcttccatt      180

agagaaggtt tggtatgtta ggcaacgcag ttctcggatg tcagtccgga tcggaggagt      240

cacagtctgt catgtgatga tatattgctt catttttgtt ttgcagcaaa agaaggacac      300

ggtgtactac acatcgctgt tcaatgaccg cgtgctccat gagatgctga gtcctatggg      360

ctgtcgcgtg accaacgaac tcatggaaca ttatttagat ggtgttctgc ctcgagcaag      420

tcatttagac tacgataata gcactctgaa tggcttacat gtgtttgctt catccatgca      480

ggcgctgtat cagcacatgt taaagtgtgt aagtgtttca ggttcgataa ccccgcgata      540

tgacacgtaa atagcgatat cgtggcacca gacgtcagtc acagtcttcc ccggtcgaga      600

cgcatcttat atcgcgatat atcgcggttt atcgcagtat gtcgcgatat atcgctccaa      660

aacactccgg atgactttct atcgccgaat atcacctcat atcgtcttat atcgcggtgt      720

atcgcgggtt atcgtcatat atcgcggtta tgtcgcgaca taaccgtcat gtcgcgacta      780

tcgccgcata tcgccactat cgcgacttgg cacggtgcca acaatagttg cctctagggt      840

ggtcgtgtgg tggtaggggg ctgcttacgg tttgcaaacc ggagaggtcg cacacgctga      900

ttgtcggttt ggaagcgttg tttacacatg tctttgtctt ggcagcccgc gttggcatgt      960

actggcaaaa cgccagcttg gatgtacttc ttggaggtgg aacacaaggt cagttaaggt     1020

tgccaggtag gttaaaacgc agaaaccatt gttctaccgg tttcctaaaa cgccgttcaa     1080

cgtgttttgc agctcaaccc ctggaggggc acggcaaaag ccgcggccga ggctgacctt     1140

ttgctgaact acttggaaac gttcctgctg cagttctga                            1179


<210> 5
<211> 273
<212> PRT
<213> Macaca mulatta

<400> 5
Met Val Ala Val Ile Leu Leu Ala Thr Ile Pro Ser Leu Leu Leu Ile 
1               5                   10                  15      


Leu Gly Gly Trp Val Leu Pro Ala Val Val Leu Thr Phe Phe Ser Pro 
            20                  25                  30          


Gly Thr Glu Leu Pro Ser Pro Pro Ser Val Trp Phe Glu Ala Glu Phe 
        35                  40                  45              


Phe His His Ile Leu His Trp Thr Pro Ile Pro Asn Gln Ser Glu Ser 
    50                  55                  60                  


Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr Gly Thr Gly Arg Trp Asn 
65                  70                  75                  80  


Ser Ile Ser Asn Cys Ser Gln Ala Leu Ser Tyr Asp Leu Thr Ala Val 
                85                  90                  95      


Thr Leu Asp Leu Tyr Arg Ser Asn Gly Tyr Trp Ala Arg Val Arg Ala 
            100                 105                 110         


Val Asp Gly Ser Arg His Ser Asn Trp Thr Val Thr Asn Thr Arg Phe 
        115                 120                 125             


Ser Leu Asp Glu Val Thr Leu Thr Val Gly Ser Val Lys Leu Glu Ile 
    130                 135                 140                 


His Asn Gly Phe Ile Leu Gly Lys Ile Gln Pro Pro Arg Pro Lys Met 
145                 150                 155                 160 


Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile Phe Ser His Phe Arg Glu 
                165                 170                 175     


Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly Asn Phe Thr Phe Thr His 
            180                 185                 190         


Lys Lys Val Lys His Glu Asn Phe Ser Leu Leu Thr Ser Gly Glu Val 
        195                 200                 205             


Gly Glu Phe Cys Val Gln Val Lys Pro Ser Val Thr Ser Arg Thr Asn 
    210                 215                 220                 


Lys Gly Met Trp Ser Lys Glu Glu Cys Val Ser Leu Thr Arg Gln Tyr 
225                 230                 235                 240 


Phe Thr Val Thr Asn Val Ile Ile Phe Phe Ala Phe Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu Gln Leu Tyr Val Arg Arg 
            260                 265                 270         


Arg 
    


<210> 6
<211> 263
<212> PRT
<213> Homo sapiens

<400> 6
Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val 
            20                  25                  30          


Trp Phe Glu Ala Glu Phe Phe His His Ile Leu His Trp Thr Pro Ile 
        35                  40                  45              


Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr 
    50                  55                  60                  


Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser 
65                  70                  75                  80  


Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr 
                85                  90                  95      


Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr 
            100                 105                 110         


Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly 
        115                 120                 125             


Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln 
    130                 135                 140                 


Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile 
145                 150                 155                 160 


Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly 
                165                 170                 175     


Asn Phe Thr Phe Thr His Lys Lys Val Lys His Glu Asn Phe Ser Leu 
            180                 185                 190         


Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser 
        195                 200                 205             


Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile 
    210                 215                 220                 


Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn Val Ile Ile Phe Phe 
225                 230                 235                 240 


Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu 
                245                 250                 255     


Gln Leu Tyr Val Arg Arg Arg 
            260             


<210> 7
<211> 153
<212> PRT
<213> Cercopithecine herpesvirus 8

<400> 7
Met Arg Arg Arg Arg Arg Ser Phe Gly Ile Ile Val Ala Gly Ala Ile 
1               5                   10                  15      


Gly Thr Leu Leu Met Met Ala Val Val Val Leu Ser Ala His Asp His 
            20                  25                  30          


Glu His Lys Glu Val Pro Pro Ala Cys Asp Pro Val His Gly Asn Leu 
        35                  40                  45              


Ala Gly Ile Phe Lys Glu Leu Arg Ala Thr Tyr Ala Ser Ile Arg Glu 
    50                  55                  60                  


Gly Leu Gln Lys Lys Asp Thr Val Tyr Tyr Thr Ser Leu Phe Asn Asp 
65                  70                  75                  80  


Arg Val Leu His Glu Met Leu Ser Pro Met Gly Cys Arg Val Thr Asn 
                85                  90                  95      


Glu Leu Met Glu His Tyr Leu Asp Gly Val Leu Pro Arg Ala Ser His 
            100                 105                 110         


Leu Asp Tyr Asp Asn Ser Thr Leu Asn Gly Leu His Val Phe Ala Ser 
        115                 120                 125             


Ser Met Gln Ala Leu Tyr Gln His Met Leu Lys Cys Val Ser Val Ser 
    130                 135                 140                 


Gly Ser Ile Thr Pro Arg Tyr Asp Thr 
145                 150             


<210> 8
<211> 770
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Phe Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210> 9
<211> 769
<212> PRT
<213> Homo sapiens

<400> 9
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Ile Ser 
    450                 455                 460                 


Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr Asn 
465                 470                 475                 480 


Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro Pro 
                485                 490                 495     


Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe Ser 
            500                 505                 510         


Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu Ala 
        515                 520                 525             


Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile Thr 
    530                 535                 540                 


Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser Phe 
545                 550                 555                 560 


Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile Leu 
                565                 570                 575     


Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu Arg 
            580                 585                 590         


Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu Arg 
        595                 600                 605             


Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val Glu 
    610                 615                 620                 


Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr Thr 
625                 630                 635                 640 


Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly Tyr 
                645                 650                 655     


Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr Leu 
            660                 665                 670         


Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg Pro 
        675                 680                 685             


Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro Tyr 
    690                 695                 700                 


Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn Thr 
705                 710                 715                 720 


Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln Phe 
                725                 730                 735     


Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe Glu 
            740                 745                 750         


Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser Pro 
        755                 760                 765             


Met 
    


<210> 10
<211> 770
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Met Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


