                         SEQUENCE LISTING

<110>  Autolus Limited
 
<120>  CELL

<130>  P115644PCT

<150>  GB 1813178.9
<151>  2018-08-13

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 chimeric antigen receptor (CAR) complementarity 
       determining region (CDR) CDR1

<400>  1

Gly Arg Thr Phe Ser Met His Ser 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR2

<400>  2

Val Thr Trp Ser Gly Asp Thr Phe 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR3

<400>  3

Lys Asp Asp Pro Tyr Arg Pro Ala Tyr Asp Tyr 
1               5                   10      


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR1

<400>  4

Gly Arg Thr Phe Ser Ser Tyr Val 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR2

<400>  5

Ile Ser Trp Ser Gly Gly Ser Thr 
1               5               


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR3

<400>  6

Ala Ala Met Glu Leu Arg Gly Gly Ser Tyr Asn Tyr Ala Ser Ser Arg 
1               5                   10                  15      


Gln Tyr Asp Tyr 
            20  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR1

<400>  7

Glu Ile Ala Phe Ser Asn Phe Asn 
1               5               


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR2

<400>  8

Ile Ser Ser His Gly Asp Thr Asn Tyr 
1               5                   


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR3

<400>  9

Asn Ala Asn Asp Pro Phe Leu Ser Val Ser Asp Phe 
1               5                   10          


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR1

<400>  10

Gly Ser Ile Phe Ser Ile Asn Ala 
1               5               


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR3

<400>  11

Ala Ala Ile Ser Gly Trp Gly Arg Ser Ile Arg Val Gly Glu Arg Tyr 
1               5                   10                  15      


Glu Tyr Asp Tyr 
            20  


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR1

<400>  12

Gly Arg Thr Ser Ser Ser Ser Thr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR2

<400>  13

Ile Thr Leu Ser Gly Gly Ser Thr 
1               5               


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR3

<400>  14

Ala Ala Arg Arg Trp Ser Asn Asn Arg Gly Gly Tyr Asp Arg Ala Gly 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR1

<400>  15

Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR2

<400>  16

Ile Thr Trp Ser Gly Gly Ser Thr 
1               5               


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CAR, CDR3

<400>  17

Ala Met Leu Leu Arg Gly Gly Leu Tyr Asp Tyr Thr Asp Tyr Ile Leu 
1               5                   10                  15      


Tyr Asn Tyr 
            


<210>  18
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 domain antibody (dAb) sequence, CD33 dAb P1.E4 - 44738

<400>  18

Gln Val Gln Leu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Met His Ser 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
        35                  40                  45              


Ala Val Thr Trp Ser Gly Asp Thr Phe Ala Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Gly Ile Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Lys Asp Asp Pro Tyr Arg Pro Ala Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 dAb sequence, CD33 dAb P1.H3- 44739

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Met Glu Leu Arg Gly Gly Ser Tyr Asn Tyr Ala Ser Ser Arg 
            100                 105                 110         


Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  20
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 dAb sequence, CD33 dAb P1.G8 - 44742

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Glu Ile Ala Phe Ser Asn Phe 
            20                  25                  30          


Asn Met Gly Trp Tyr Arg Gln Gly Ser Gly Lys Gln Arg Thr Leu Val 
        35                  40                  45              


Ala Gln Ile Ser Ser His Gly Asp Thr Asn Tyr Leu Asp Ser Met Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Asn Lys Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asn Asp Pro Phe Leu Ser Val Ser Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  21
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 dAb sequence, CD33 dAb P2.A7 - 46173

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ile Ser Gly Trp Gly Arg Ser Ile Arg Val Gly Glu Arg Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  22
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 dAb sequence, CD33 dAb P2.B12 - 46174

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Ser Ser Ser 
            20                  25                  30          


Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Leu Ser Gly Gly Ser Thr His Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Trp Ser Asn Asn Arg Gly Gly Tyr Asp Arg Ala Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  23
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 dAb sequence, CD33 dAb P2.F2 - 46176

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Met Leu Leu Arg Gly Gly Leu Tyr Asp Tyr Thr Asp Tyr Ile 
            100                 105                 110         


Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR1

<400>  24

Gly Arg Ser Ile Asn Thr Tyr Ala 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR2

<400>  25

Ile Asn Tyr Asn Ser Arg Tyr Thr 
1               5               


<210>  26
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR3

<400>  26

Ala Ala Thr Ser Tyr Tyr Pro Thr Asp Tyr Asp Val Ala Ser Arg Val 
1               5                   10                  15      


Ala Thr Trp Pro Ser 
            20      


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR1

<400>  27

Gly Ile Ser Leu Asn Ala 
1               5       


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR2

<400>  28

Ile Lys Ile Gly Gly Val Ser 
1               5           


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR3

<400>  29

Asn Thr Tyr Pro Pro Tyr Leu Asn Gly Met Asp Tyr 
1               5                   10          


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR1

<400>  30

Gly Arg Ser Phe Asn Thr Asp Ala 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR2

<400>  31

Ile Ser Trp Asp Gly Thr Arg Thr 
1               5               


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR3

<400>  32

Ala Ala Glu Pro Gln Lys Ala Trp Pro Ile Gly Thr Ser Ala Ala Gly 
1               5                   10                  15      


Phe Arg Ser 
            


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR1

<400>  33

Gly Ser Ser Ile Ser Val 
1               5       


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR2

<400>  34

Ile Ser Trp Ser Asp Gly Asn Thr 
1               5               


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR3

<400>  35

Ala Val Glu Pro Arg Gly Trp Pro Lys Gly His Arg Tyr 
1               5                   10              


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR1

<400>  36

Gly Ser Ser Phe Ser Ile Asn Val 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR2

<400>  37

Ile Ser Trp Ser Asp Gly Ser Thr 
1               5               


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR3

<400>  38

Ala Val Glu Pro Arg Gly Trp Pro Lys Gly His Arg Tyr 
1               5                   10              


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR1

<400>  39

Gly Ser Ile Phe Arg Ile Asn Ala 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR2

<400>  40

Val Asn Trp Ile Gly Gly Thr Thr 
1               5               


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD123 CAR, CDR3

<400>  41

Ser Ala Thr Asp Lys Gly Gly Ser Ser Arg Tyr 
1               5                   10      


<210>  42
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 dAb sequence, CD123 dAb H11 45897

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Ser Ile Asn Thr Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Asn Tyr Asn Ser Arg Tyr Thr His Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Asn Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Ser Tyr Tyr Pro Thr Asp Tyr Asp Val Ala Ser Arg Val 
            100                 105                 110         


Ala Thr Trp Pro Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  43
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 dAb sequence, CD123 dAb F8 45888

<400>  43

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Val Ser Gly Ile Ser Leu Asn Ala Met 
            20                  25                  30          


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Leu Arg Glu Trp Val Ala 
        35                  40                  45              


Val Ile Lys Ile Gly Gly Val Ser Asn Tyr Ala Val Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Asn Thr 
                85                  90                  95      


Tyr Pro Pro Tyr Leu Asn Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  44
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 dAb sequence, CD123 dAb A7 45865

<400>  44

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Phe Ser Gly Arg Ser Phe Asn Thr Asp 
            20                  25                  30          


Ala Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asp Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Gln Lys Ala Trp Pro Ile Gly Thr Ser Ala Ala Gly 
            100                 105                 110         


Phe Arg Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  45
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 dAb sequence, CD123 dAb B4 45868

<400>  45

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Ile Ser Val Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Ile Ser Trp Ser Asp Gly Asn Thr Asn Tyr Ala Asp Ser Val Asn Gly 
    50                  55                  60                  


Arg Phe Ser Val Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Val 
                85                  90                  95      


Glu Pro Arg Gly Trp Pro Lys Gly His Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  46
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 dAb sequence, CD123 dAb A10 45866

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Gly Ser Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Ile Asn 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Asp Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Val Glu Pro Arg Gly Trp Pro Lys Gly His Arg Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  47
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD123 dAb sequence, CD123 dAb C11 45874

<400>  47

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Thr Ala Val Asn Trp Ile Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ser Ala Thr Asp Lys Gly Gly Ser Ser Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR1

<400>  48

Gly Phe Thr Phe Gly Asn His Asp 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR2

<400>  49

Ile Asp Ser Gly Gly Asn Val Ile 
1               5               


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR3

<400>  50

Ala Thr Asp Leu Asp Ser Gly Ala Glu Ser Leu Glu Ser Val Tyr 
1               5                   10                  15  


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR1

<400>  51

Gly Phe Ala Phe Gly Ser Ala Asp 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR2

<400>  52

Ile Asp Ser Gly Gly Asn Thr Gln 
1               5               


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR3

<400>  53

Thr Asp Leu Asp Pro Thr Thr Asp Ser Leu Glu Asn Val Tyr 
1               5                   10                  


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR1

<400>  54

Gly Arg Thr Phe Ser Ala Tyr Phe 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR2

<400>  55

Ile Asn Trp Asn Gly Asp Ser Ser 
1               5               


<210>  56
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR3

<400>  56

Ala Ala Asp Thr His Gly Ala Val Gly Leu Gly Ser Glu Arg Leu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR1

<400>  57

Gly Ile Gly Val Ser Ser Thr Gly 
1               5               


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR2

<400>  58

Ile Asp Arg Asp Gly Thr Thr 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR3

<400>  59

Thr Val Val Gly Asp Tyr Tyr 
1               5           


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR1

<400>  60

Gly Phe Ile Phe Gly Asn Tyr Asp 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR2

<400>  61

Ile Ser Ser Gly Gly Asn Asp Ile 
1               5               


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR3

<400>  62

Ala Ala Asp Leu Asp Pro Gly Thr Asp Ser Leu Asp Asn Ile His 
1               5                   10                  15  


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR1

<400>  63

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR2

<400>  64

Ile Ser Ser Ser Asp Gly Ser Thr 
1               5               


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CLL-1 CAR, CDR3

<400>  65

Ala Glu Ala Val Tyr Tyr Ala Gly Val Cys Val Ala Met Tyr Asp Ser 
1               5                   10                  15      


<210>  66
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 dAb sequence, CLL-1 dAb 44548

<400>  66

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Thr Phe Gly Asn His 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Val Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asp Ser Gly Gly Asn Val Ile Val Tyr Glu Glu Val Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Gly Leu Lys Pro Glu Asp Ala Gly Met Tyr Phe Cys 
                85                  90                  95      


Ala Thr Asp Leu Asp Ser Gly Ala Glu Ser Leu Glu Ser Val Tyr His 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  67
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 dAb sequence, CLL-1 dAb 44544

<400>  67

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Glu Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Thr Gly Phe Gly Phe Ala Phe Gly Ser Ala 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Val Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asp Ser Gly Gly Asn Thr Gln Thr Tyr Glu Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Ser Glu Asp Ala Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Asp Leu Asp Pro Thr Thr Asp Ser Leu Glu Asn Val Tyr His 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Ile Val Ser Ser 
        115                 120         


<210>  68
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 dAb sequence, CLL-1 dAb 44538

<400>  68

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Ala Tyr 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Asp Ser Ser Trp Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr His Gly Ala Val Gly Leu Gly Ser Glu Arg Leu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  69
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 dAb sequence, CLL-1 dAb 44546

<400>  69

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Gly Val Ser Ser Thr 
            20                  25                  30          


Gly Met Gly Trp Ser Arg Gln Thr Pro Gly Lys Gln Val Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Asp Arg Asp Gly Thr Thr Asn Tyr Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr His Cys Thr 
                85                  90                  95      


Val Val Gly Asp Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  70
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 dAb sequence, CLL-1 dAb 44545

<400>  70

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Ile Phe Gly Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Val Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Ser Gly Gly Asn Asp Ile Val Tyr Glu Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Asp Met Ala Ser Val Lys Pro Glu Asp Ala Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Asp Pro Gly Thr Asp Ser Leu Asp Asn Ile His His 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Phe Val Ser Ser 
        115                 120         


<210>  71
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLL-1 dAb sequence, CLL-1 dAb 44536

<400>  71

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Ala Val Tyr Tyr Ala Gly Val Cys Val Ala Met Tyr Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR1

<400>  72

Gly Ile Phe Lys Thr Asn Tyr 
1               5           


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR2

<400>  73

Phe Thr Asn Asp Gly Ser Thr 
1               5           


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR3

<400>  74

Tyr Gly Leu Gly His 
1               5   


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR1

<400>  75

Gly Thr Ile Ser Ser Ile Arg Tyr 
1               5               


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR2

<400>  76

Ile Thr Ser Ser Gly Asn Thr 
1               5           


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR3

<400>  77

Tyr Thr Met Gly Tyr 
1               5   


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR1

<400>  78

Gly Ile Phe Ser Thr Asn Tyr 
1               5           


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR2

<400>  79

Phe Thr Asn Asp Gly Gly Thr 
1               5           


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR3

<400>  80

Cys Gly Leu Gly His 
1               5   


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR1

<400>  81

Gly Ser Ile Ser Ser Ile Arg Tyr 
1               5               


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR2

<400>  82

Ile Thr Ser Ser Gly Ser Thr 
1               5           


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR3

<400>  83

Tyr Thr Met Gly Tyr 
1               5   


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR1

<400>  84

Gly Ile Phe Ser Thr Asn His 
1               5           


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR2

<400>  85

Phe Thr Asn Asp Gly Ser Thr 
1               5           


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FLT3 CAR, CDR3

<400>  86

Tyr Gly Leu Gly His 
1               5   


<210>  87
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 dAb sequence, FLT3 dAb B5

<400>  87

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Phe Lys Thr Asn Tyr 
            20                  25                  30          


Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
        35                  40                  45              


Ala Phe Thr Asn Asp Gly Ser Thr Leu Tyr Gly Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Tyr Thr Val Ser Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Gly 
                85                  90                  95      


Leu Gly His Trp Gly Gln Gly Thr Gln Val Ile Val Ser Ser Glu Pro 
            100                 105                 110         


Lys Thr Pro Lys Pro Gln Pro Ala Ala Ala Asp Asp Asp Asp Lys Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His 
    130                 135                 140                 


His His His Gly Ala Ala 
145                 150 


<210>  88
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 dAb sequence, FLT3 dAb G3

<400>  88

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Ser Ile Arg 
            20                  25                  30          


Tyr Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Val Val 
        35                  40                  45              


Ala Tyr Ile Thr Ser Ser Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Tyr 
                85                  90                  95      


Thr Met Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
            100                 105                 110         


Pro Lys Ile Pro Gln Pro Gln Pro Ala Ala Ala Asp Asp Asp Asp Lys 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His Gly Ala Ala 
145                 150     


<210>  89
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 dAb sequence, FLT3 dAb H5

<400>  89

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Phe Ser Thr Asn Tyr 
            20                  25                  30          


Met Val Trp Cys Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
        35                  40                  45              


Ala Phe Thr Asn Asp Gly Gly Thr Leu Tyr Ala Asp Ser Leu Lys Gly 
    50                  55                  60                  


Arg Phe Ser Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Leu Leu Leu 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Cys Gly 
                85                  90                  95      


Leu Gly His Trp Gly Arg Gly Thr Lys Val Thr Val Ser Ser Glu Pro 
            100                 105                 110         


Lys Ile Pro Gln Pro Gln Pro Ala Ala Ala Asp Asp Asp Asp Lys Glu 
        115                 120                 125             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His 
    130                 135                 140                 


His His His Gly Ala Ala 
145                 150 


<210>  90
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 dAb sequence, FLT3 dAb D12

<400>  90

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Arg 
            20                  25                  30          


Tyr Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Ser Val 
        35                  40                  45              


Ala Trp Ile Thr Ser Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Gln 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Thr Met Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
            100                 105                 110         


Pro Lys Ile Pro Gln Pro Gln Pro Ala Ala Ala Asp Asp Asp Asp Lys 
        115                 120                 125             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 


His His His His Gly Ala Ala 
145                 150     


<210>  91
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 dAb sequence, FLT3 dAb F10

<400>  91

Gln Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Phe Ser Thr 
            20                  25                  30          


Asn His Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Ala Phe Thr Asn Asp Gly Ser Thr Leu Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Val Ile Ser Arg Asp Asn Ala Lys Tyr Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Gly Leu Gly His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


Glu Pro Lys Thr Pro Lys Pro Gln Pro Ala Ala Ala Asp Asp Asp Asp 
        115                 120                 125             


Lys Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His 
    130                 135                 140                 


His His His His His Gly Ala Ala 
145                 150         


<210>  92
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge spacer sequence

<400>  92

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  93
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  suicide gene sequence

<400>  93

Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Pro 
            20                  25                  30          


Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    50                  55                  60                  


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
65                  70                  75                  80  


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
                85                  90                  95      


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            100                 105                 110         


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
        115                 120                 125             


Cys Lys Cys Pro Arg Pro Val Val 
    130                 135     


<210>  94
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  suicide gene sequence, FRB-FKBP12-L3-dCasp9

<400>  94

Met Ala Ser Arg Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu 
1               5                   10                  15      


Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe 
            20                  25                  30          


Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr 
        35                  40                  45              


Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu 
    50                  55                  60                  


Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp 
65                  70                  75                  80  


Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser 
                85                  90                  95      


Lys Leu Glu Tyr Ser Gly Gly Gly Ser Leu Glu Gly Val Gln Val Glu 
            100                 105                 110         


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
        115                 120                 125             


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp 
    130                 135                 140                 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
145                 150                 155                 160 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
                165                 170                 175     


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
            180                 185                 190         


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
        195                 200                 205             


Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala 
225                 230                 235                 240 


Leu Glu Ser Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met 
                245                 250                 255     


Glu Pro Cys Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg 
            260                 265                 270         


Glu Ser Gly Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys 
        275                 280                 285             


Leu Arg Arg Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly 
    290                 295                 300                 


Asp Leu Thr Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln 
305                 310                 315                 320 


Gln Asp His Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His 
                325                 330                 335     


Gly Cys Gln Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr 
            340                 345                 350         


Asp Gly Cys Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly 
        355                 360                 365             


Thr Ser Cys Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln 
    370                 375                 380                 


Ala Cys Gly Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr 
385                 390                 395                 400 


Ser Pro Glu Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr 
                405                 410                 415     


Pro Phe Gln Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser 
            420                 425                 430         


Ser Leu Pro Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro 
        435                 440                 445             


Gly Phe Val Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu 
    450                 455                 460                 


Thr Leu Asp Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln 
465                 470                 475                 480 


Ser Leu Leu Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr 
                485                 490                 495     


Lys Gln Met Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe 
            500                 505                 510         


Lys Thr Ser Ala Ser 
        515         


<210>  95
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A-like cleavage site sequence

<400>  95

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


