﻿                         SEQUENCE LISTING

<110>  WuXi Biologics (Shanghai) Co., Ltd.

<120>  TRANSCRIPTIONAL REGULATORY ELEMENT AND ITS USE IN ENHANCING THE EXPRESSION OF EXOGENOUS PROTEIN

<130>  6711-180837I-SH

<160>  12

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  27
<212>  DNA
<213>  Artificial Sequence

<400>  1
gcaaaaaagg gaataagggc gacacgg                                            27

<210>  2
<211>  28
<212>  DNA
<213>  Artificial Sequence

<400>  2
catagcccat atatggagtt ccgcgtta                                           28

<210>  3
<211>  3619
<212>  DNA
<213>  Chinese hamster

<400>  3
gatctgcctg cctctgcccc gtgagtgctg ggattaaagg ccagcaccgc catgcctggc        60
ctcctttaag tgcaggtgta gcacgccaga aataccctgc tggtgacagt gtgagccaca       120
tgcgtgagac tgctgcagag gtcccagctt aggttgtgcc cttctttctt gagaaatgtc       180
ttacttggtg attttgagtg gaaacatgta tttagctgac atatgagcct agtcttttat       240
gtataaatgt gtgttatatt tctagataca aaaatattaa aaattagaaa tcttcagggc       300
tggagagggg ttcattggtt aagagctcat tggttaaggg ctgctcctgt ataggacccg       360
ggttacctgt cagcaccgta tgacggctct caaccatctg cagctcccgt tccagaggac       420
ccagtgtctt cttctggcct ctacagacat acatatagac aaaacaccca tacacaaaaa       480
tttaattaga aatcttaatt tttttctttc aattttctag attgactggg gataactttt       540
ttgttaactt tactgtcttg aggataacgt tcagtatgag ttgtatttct agagtttgtc       600
tttattttta ggcaaaaata acctttatta ccattttggg gggtgactgt tttacaactt       660
ttccaacttt ctgcttcatc tcttgtgtcc tatataggcc cctatttact gtcattatta       720
gagataggac ttgatgtcat gtcaactcca tctttgttat aaatctcaag aagagctaat       780
ttcttttgtg ttattacaac caaaaataaa caaggtagct tataaacagt gacttatttt       840
tatagttcta gatatgggaa gatcatggtg acagtagatt caatgtctag ttggaagttg       900
actcttcttc atagatggaa tccttgctat aatataatct caggatggaa gggatgagct       960
aagccctctg ggatctctta ttaatctgtt cattcattta cttattgcat agtgctctaa      1020
ttctgttcat ggagactctg ttcttacaca ttaggtggtt agggagggac atgatcaatc      1080
aggacatagg agcaacaata atttttatta tatttcccaa aatacatggc agttcctgac      1140
cttgctttat tactgcaaac atacagcttg tggccattgg acttagccat atgagaaatg      1200
taagaattta ttttatattg tagctgcaaa tggtaggttc atcaaattgt gccttaagtt      1260
cacatcttaa tttgctacaa aaaaaaaaga ggagtagtgt aagttacatt taattttcaa      1320
ttacttagta acagtttgta agtgctactt gatcctgttt tatatctagc attgagtata      1380
gatcaacaag tgtttcaatt cttgtttgga catgctgttc tctccttcat cacaagttac      1440
ttctggctaa acaaggcaca aatttcgcat gaccaccaat ccaaggacag ggcgacaatt      1500
ttaatgagtt tcattgagag ctggccaact gagcatctgt tccttttgtt ttcctgtacg      1560
tggtaagcca gtgtttctac actccttagc cttgttgctg tgtgtatagt gtggggtgga      1620
tttgtttttg ctgttctttt ttcttttttc taccctctac ttcagtggtg cacggttaga      1680
aatcttgtgg cgtctggcac ggtggtataa ttccttccat gctcttgggt gaggaaataa      1740
gtttgctcat tgctgctcat cagtctgttt cacttgctcc cagatggtga ccttctcgtc      1800
ccattcttgc ttgttttaac attattctga cacctatttt ctttcattgt ccccttaacc      1860
actctaattg aataatgatt tctgtaattt ccatttggaa cacaaccagc ttcctggttc      1920
cttttattgg cccacatcct gtcttctagt tcattgcttc agatttgagc caaatcatca      1980
aataaaaata cgtaactgaa aaaaatgttt attgcagtgg cctcctctag catggcaaca      2040
atgagagttt tcctttctta ttgctaaaca tgttatatct gtctcatgat ttcatactgt      2100
ctctcctggc ctcatttact gcttgacctt taaaagaaat gactcaaaga tatttttgta      2160
gttctgtaag catttctcta gttcttgttc ttcaccttta gttcttaaca gtagttttgt      2220
ctgctacact gacgtggctg tgaggacttt ccttcagaaa ctggcgtctg atactgattc      2280
aaactggtct ccattgtggc ctacatgtcc agctgtctcc atgtaacgcc actgaaatac      2340
agtgaagcca gccttttttt cccccttatg gttcaaagca actgaatttc agtcagagta      2400
attttggttt gggtatcaat actaattgta gtcttagacc ttttaattat tacttgtttg      2460
cattttacag aagacattgg tccttctcaa aagcagagat gaaacctgta gtattttgtg      2520
tgtagttttc ctctgctggt tgccctgtaa ctattcagtt cctgtaagga agcacagctg      2580
cttcataagc taccttaggc tgacagcagt ctcctgaaag aaagagttca agaaagaaac      2640
atttaaaaat aaaaatgggg aggggtccaa gtagtatttg aagccatgaa atatcttgaa      2700
tatagtttgc ttttttgttt tgttttgtct gtctgtctgt ccgatgtagc tttggccata      2760
tcaaccaggc tgtccttgaa ctcacagaaa tccacctgcc tccgcctccc aagtgctgga      2820
tgcaccacca tgccagctag tttgcttttt agagcatctc atctgctgct cacagccctg      2880
gtgctttatg ggatttgttt ggggaacatg atgagctcta tatttattgt agctttaaat      2940
ggacagcggt tattgactgt cagcttagtc tttaaaatct ataatcacat tgtacctaat      3000
tgtcaacctt catgtttttt aattatgaaa aaaactgaga acattaattt ttatgttatc      3060
ttgttattga ctttattgaa atactacaga aaattttggt ttgaggcttt tccataattt      3120
acccttacac ctcacacccc ttccataaac atgtgcagtt aaaattgaat tgttcgggca      3180
cttctacctt gatacctggc ctacagtggg aaaggtctgt ctttctttgg aataagccca      3240
tcagtggcct tgtgtacatt ctgtattttt gttgtttgtt attactgttt tttacttggg      3300
actaataatc tgtttgaaac tgactgagat agaaagatgt gatgttcctt cccactcact      3360
ccggattttg atagaagact tgttttattt atttccaaaa ttatatccgc aggaaacaag      3420
ctgtttaaat tcagattatg ctgaagcaaa atggtcctgg tatgagaagc aacgtgctgt      3480
tttacgagca cagagtccct tttctcataa ctgattgata gtaaatattt tcctgaagaa      3540
ttattgccaa ccatgaacag tgcaactgtt tcactttttt tccgtgctac ttgctgtacc      3600
agccattgtc ggtaattaa                                                   3619

<210>  4
<211>  1114
<212>  DNA
<213>  Chinese hamster

<400>  4
gatctgaagt ttggatctgc agaacccaca caaaggccta cgggcttagt agtgtacctg        60
caatttcagc acttggaagg ctgagaaagg atcccaaggg cagctggcta gctaggctag       120
tgttagctga gagctctggg ttcgtggagc gactctggtt cagtgaataa gatagagagt       180
gacatcagct ttgggcttcc acagcaaatg agctcacttg catgcaaaca gaaatgcaaa       240
cacatgcaca aagcaaaaca aaaggaacac aggccaaagg tgggtcattc ctataccatc       300
ccctcagcag ggtgcagtcc ccacaccctg acccagttcc ctcatgatgt tagagaaaat       360
aactttgccc ccttcaacga acatttcagc tccagagaac ctggcccact ttgaaagctt       420
taattagaaa tgtgcaatta cccggaacag atgtctgttg tgattgtgga gacataggtt       480
aaagaatcac acagcagttt gcgtggttac agaaaggttg caagtaactt taaaacacag       540
tttttggtaa gtctccaaca tgttacctaa catagcatgg cctcgattac atgtaagcag       600
tgagtctccg gctgcctggt ttgtgagggt aatgtacttc agcaatagtg ctgaggctgt       660
acagtgagtg actcatcacc ctaaaaaagt atcgaattcc agtcttcaga gttagctttc       720
agtaaaacca agtcagtggt gaaatggctc agtaggtaag ggcacccgct gccaagccca       780
agacctgtgt cctgtccctg ggatccagtt ggtggaaaga gagaacggac tcctgcaagg       840
tggcctctga cctacatgcc tgaattctgc cagacattaa gtaaaaacaa acgcaaaaag       900
ggaagtgggc tcacgcataa ggcactcact ggactctact cttctactct gtggttactt       960
tttggtgttc aagcatacca taccttgatc tacatgattt ttactccaaa gacacagcca      1020
gggtaatgtt gtgtgatgga tcagtcttat ttgttacttg tttactagta cttactgaga      1080
ttgtcgatgg ctttaatgtc aacatgagtg tgga                                  1114

<210>  5
<211>  4068
<212>  DNA
<213>  Chinese hamster

<400>  5
gatcttctag gtctggctct gagttgaaag gctctgatgc tgggcgaaac atctctcctc        60
tggggctcag ttttctcatc tgttagaaaa ggacacagct gacctgttgg cttctaatag       120
ttggacagag gctaggattc tgagtctcat tttactacaa atattctttt aatttcttaa       180
gtcactaaac agcatcagca aggcagggtc gagacatgcg agcaagaatg agattggatt       240
ctgactcagg tttcaacttg ctgtcaatta ctgacaatgt aagttcattc atcttataga       300
cttttgtaga acttttgttt ctctccacta taatttcgtt actgttccat attacagtat       360
gctaaagtta atggtaaaag ttctcacaga attcctagtc ttttcctctt catatttaat       420
ctcctttcct tcctcctgtc cttactcatt gtgaaattct cttttgtatg catgacttgg       480
aaacatattt ccttggtggt aaggtagtag gagacaattt attcactttt cacgtatgtc       540
gtaattggca tattgctgat aaagtttttc aaccatggga acatggtctt gtaagaatta       600
tttcacattt ttcccagtcc aagcccataa tgaaaattga ttctgaattt tttctgtatt       660
tttaattctt ctgtttgcag ttgtaggaga ataaccctgc agcatctgag agaccaagct       720
aattacaaga atgactagaa atcctttgca tttttaaaac aattttatac atatgtcact       780
ttgtctttct aaaaaataaa aataaaaaaa atacctaaga gccgagtttg tgttaaaggc       840
taatgattgt attgtacaat tagtaagaat taaggacaaa ggtctcttta cctgaagttt       900
cctgggtgct tttattcatt cattcattca ttcattcatt cattcattca tttagtcaaa       960
ttagttcatt tctgatgcaa tgactgactg attactcccc agaccaatgc tccttcctgt      1020
tttaggttca cagatagcat ttcctacctt ctcttgtcct tccttttgtc caaaattttg      1080
agttctagac aaccacagaa ttgcctagaa atgctggaca gaattcatgc atctgattcc      1140
tggtaagacc gtcgatgcac tataaacttg cagaagctga cagcagactg ttcttcactt      1200
caactcattt atccctttcc tttgggttct gtccaaatca catcaccaga tcacaagaac      1260
ctaacatcag attgagacgt aaatagatga tatcacattg gatttccacc attgagccac      1320
accaccagcc acctgcctga taactttcac agtcccagaa gatattatac aagttactag      1380
ggcaaaaaga gatcaaagtc tgaatcagct gtgaacccta tgaatggcaa tacctactta      1440
tcaggcaata caagcccacc cgtgtgatag tggaataaca gtaatatggg caatcactgg      1500
attgagtcct ggccccactg cagagaatcc atgccaagca ctgtaaatcc aggaagaaaa      1560
aaaaaaacct atcactgaag aagacataaa ccctagaaag gaacttacta ctcttactta      1620
actgagtgag caaagcaaca agttatcttc taagtactta tgctggtgct catacacaaa      1680
attatccatc attcttaatt agagaattct ctctagtgaa tggttgtgga ttcaaagact      1740
cataaatacc aagggtgcta agaatgagcg acaattaaga actcagccct aaacaagatt      1800
tttatacctc atcttctaag gctcagaaac attgtggaag aaggtgtcaa aagaatgtaa      1860
gagtgaaaag agtgagaagg gctgccaata tcatctttgc tatcatgaac tcacaaaagc      1920
tgcagttgtt agtgccagga ctgtgtgaca ttgtcactac caacactcag ccttgggtgg      1980
ggaggagggc ataatgtcat actcttcatc attgagccat tggttactaa cagattctag      2040
gagaatcact ctctcttgtt atgtatccat ccatgaatct acaaggctcc attgggcagt      2100
tccaaactgg aggtcagaaa aatttcactg atgaaactca ctgggacaca atcaaaaata      2160
tgaaagagct ttgtagccat ctttttttct gacaagggtg ggagaggcat aacaaggaag      2220
gtaaataatt gattgcatta tatacacata tgaaactgtc aaagaacgca atttaaaaag      2280
tacatagtaa gtggttttcc atacaattta atttattatc acacagttgt tctttacagt      2340
atgtcttgat tatctctatc cctgactccc atgtcacccc cacaaacacc ctcaatatat      2400
ctccctccac cttatcaccc cttaatttct ttcattttac tattttatag ataatccact      2460
gaattcaatt agtgctgtct gttggaaagc cgaaggagac cgatatgttg gcttgatttg      2520
acacaggtct tctgcaggtg accaagatga agtgacttga atgtgatagc catgctatga      2580
aaaagagggc ttcatgtatt gtatcaaaag ggagcgtttc tcagctcctc tctccagcct      2640
ctgtctcata ttctttctgc tccgtcttcc tctgtaacat agtaaatttg tacagaacgg      2700
tcacaagtca caaatttggt agactacatg atgaaatttg caatgacttt ggagtactta      2760
acatggattt gaatgtccat ttggcatcgt tctagaagat aagtccaaag taagtgtgct      2820
atcttaccat cttccttcct tgtaggagtc ggccacgttt cccactctag accttagctc      2880
ctctagttag ctgcttcaaa gcatcaagtg gagtccgcat aatcactttg tactaattca      2940
taagctcata aatccagaca aagtgaaagt caaatctcaa gtcctgggcc acttatttgt      3000
tttctgtgca tcggacttag gattatttgc cctcttcctg ttccactgca tcagttctgt      3060
cagtgggggg ggggggggtt gggagtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt      3120
gtgtgtgtgt tgcttacaaa gctgtcataa tgatgaaaca gagtatcagt cacatggtaa      3180
ccacatctaa gtagagaatg tgcttctaca atgtgagctt cctctcagtg tgtccatgtc      3240
atcatagagg aggcttcttt cccagtgcac atgaaggctt cagaactaag tttgaatagg      3300
actatgtgat cagccctgaa aagcctgcag tactccttgg tgctgtgctt gaaccctcct      3360
gtttctctgc gcggtctttg tagggagact atggatataa actatttggg tggtctcttt      3420
tttttcatca ggaagacaga ggtatactgt tgattctaga catgtcaggt tgaggaaatg      3480
gaccttatgc ctaattcctt cctaattcat acagagtttc agctttaaag gacagattaa      3540
tagcggtttg agatgatttc agctctgtga cctggccatt gtgctgtgtg ttagatttcc      3600
atgctggtaa gtgaaacaat tttagggctc taaaaactca cttcaggctc taagcagcac      3660
tccacctagc cagaatgggg gagatgcagc taaacagctg ctcatgtgag cagggttacc      3720
aactccagtc gacagccagg ccagcatgac tcaccagtgt gaaactgcca agaggataat      3780
ttgatctggg gctgaatgaa caggactgca gtgtctgtcc agaccaaagt gagggatcct      3840
cccttgtctg catgtgaatc cagaccacac ctactgtctt gtaggctttg cttaccccca      3900
cccctgtatc tcattatgat gctgttcaca agttgaagta gagccagcta tgagactcat      3960
tgcataatat tcacattaga aaccactctc ttcattctat ttctatcata ggatttctaa      4020
cttaacttgt tgaaggtgtg gatattgaca tctttgagaa gaagaaga                   4068

<210>  6
<211>  3949
<212>  DNA
<213>  Chinese hamster

<400>  6
gatctgtgta gctgccacaa cacttgatct cggagtgagg ccctaactcc attgatgggt        60
gtcagctctc atcagtcgca ctgttagcaa caggagatcc agctgactgc ctctcaagtt       120
atacagtgtg tgcaccagct tccaccacag cagctgctgc tgtcagtttg gaaataaagt       180
tcattcctac cttgcaggca ctttggcatt tgctttggga ttatttgcac ctcaggaaga       240
tccatcacta gttttcatta ttctgaatgc aatggattat cagcctgtaa ataatcaagt       300
agacctcact ggatttaaac attggaagct aagctatcaa gcagatttat gaagttcaca       360
tgcttgtgca atgtgagaag ctgacttttt ggagctgcag tggcagccaa ccaagcagcc       420
tgaggtttgt tcttgaaagg gagagtgtgg actaaaggaa gcctagaaag acacagaata       480
aaatcaggag ggcagatcca gttaatactg aacaccacaa gtttatttct caccactctc       540
atatacctta accaaaaggt gaacatgagt tccttcatac aaagcaaaca ctcttttctt       600
gctgaatttt tcaccaattt ggtaaccata ccttagattc aaattctagt tacctgttct       660
ttagggacag gtgtcagcac atctcagacc aagtctgttt ttatttagca taagacaccc       720
catgccatga tgcaatatcc tactgtagcc acacctttga cctttaggtt ttatgatttc       780
ctaaggacag ttatgaactc tctgcccttg agccaagatg gagtccagcc gtctttatgg       840
gaactagcag tgcaatgtga ttctctcatc cattgcattc gtcaaaaggc aattgtgagt       900
aaagggagga tgtagtggtt catctatttg cctgactgat atcctaacag ctcccctagt       960
ttttaatttt tttttagttc ttgtgaagat gtcatggctg gtctggagct cctgggtata      1020
ctgtagccta ttttactgtc taagcctctg gggtagctgg gattgctgga tcatggtgac      1080
aggtaactca ctacccaatt ttaaagtgaa tttgtaatga aaggatgatg attgttacct      1140
acttgttagg gctaggaatt gatttcttcc caacatttta gagattttcc ctgtgtatta      1200
atggcattta tcttgcatct acaattgatg ctgttcaaag ctgcccaggc tggcctctaa      1260
ctcacagaga tgcaaatgcc tctgcctccc gagtgctggg attaaaggcg tgcaccacta      1320
atgcctggct ctttttaaaa tcttttaggt tattgcttcc taagctctag tgactatggg      1380
tagatatcaa agacaataca gttttcattg gttctgtttt ggtgtgtagt ttttgttggc      1440
tactttcttc tttacacaga tttcatgtag tgcacactca tcttgagctc tctacatagc      1500
acaagaggac cttgcaggct tgattatcca gccgctaatt cctaagtgct gagtgacaag      1560
tgtgtgacac tgtgcctctc attttgttgg ttattttaga aagagtctta ctaagttgcc      1620
cagactaggc tcaaactctg aatatctccc agctttagcc tccatagtct tgcatttaca      1680
ggcagtttaa tcttgagcta acagtccctg ctgataccaa gtttttattc taggtgtcca      1740
agaggaactg tagcagtgaa ctccagtcta gccaaagaca cttgaccatt gcactctgga      1800
tcttgtcttt agatatgtat tttgggggat ttctttttaa tcaacaggaa atcaaataaa      1860
cttaaaaaag aatttacgca ggcagcactg gttcaagtat ttaatctcaa caccctgtag      1920
atataggcaa aagtatctct gagcagaaag atagccaggg ttacaaagag aaaaactgtc      1980
tcaaaaatta tatatatgtg agtgagtgtg tgcgtgttag ttattttaaa ttatatgtat      2040
aaatgtacat gcatatgcaa gagcccatgg agatcaggag aaattgtgtt ctctaagagc      2100
tgtagttact ggtgggtgaa agccaccagg gttgggagag agaaatagaa ctgtagtact      2160
atgatagaac aagaagtgct cttaacctga gttatggttc tagctcaata gatacactat      2220
tcacagttat tttaaagata ctgttgttgt tgtcttttac tgtgcatttg ggtgataaaa      2280
catgatccaa cacactcaac aaatccacat ggagtttatt ggaaaaggga ataaagggag      2340
gggtaggtgt taaccaatag ggagcagaaa tggaaagaga gaaaacagat gggaggcact      2400
tgcttataaa gggaaaggaa acagttaaga atgaggctca gtagttgggg cctttgaaac      2460
catagtcact gaactgcctt tggccaagat ttacatggtc tctgtatgca gaatcctaat      2520
tcagtcaatt aacacatgca ccacacagcc atgcaaactt tgacagtctt tgagatgtca      2580
gcaaggaaca atcacctgtg aaaaacagat cccagggcaa gggcaggtca cctggaaaag      2640
agaagagaag atggatccca gagcagggag ggaatccaag tgttagagag gccactaggc      2700
caggaaagga tctctaagga agcaacaggc ccaggagagt gctgatgtgg agtgacatgt      2760
ggagatcaag agaaaacacc agggtgggag gagagaaatt ggcagctgga tcagggccag      2820
gtcgcacaga acctagggag agggagaatc caggttatca acaattatta ctaggcagta      2880
ctacattttc tgtgtcctat tatttctgta gttacttaca aaatatttga gttataaaaa      2940
ggaataaaga gccgggcagt ggtggcacat ggcattaaca ccagcacttg ggagacacag      3000
gcagttgcat ctatgtgagt ttgaggccag cctggtctac agagggagtc ccaggaccaa      3060
aagccacaga gtaactttgt catacaaact gatccagtag gcttcatctc agatacgcag      3120
tgatggttca acatacaaaa atcagtaact gtaatccacc ataaaaataa actttaaaaa      3180
acactttttt attatccctt tacatgctta caaagtcatt gataagccag gtattggggg      3240
tgcatgcctt taatcccagt acttgggagg cagaggcagg tggatcactg tgagttcaag      3300
gccagcctga tctccagagc gagtgccagg ataggcttca aagctgcacg gagaaaccct      3360
gtcttgaaaa accaataaat aaataaataa ataaatagtc attgacaaga aacaaacatc      3420
ataaaagtct tggagatatt atggatacaa tttacataca cacacataat gaaggacatt      3480
tacagcaaac ctatagacaa catcaaatac aatggagaga aaaaacaaag gaattcctat      3540
aaaatctgta acttgacaag tttgtgaagt ctatatctac tcaatacagt acttgaagtt      3600
ctagatagac ccattaaaca gctaaaggac aacaaggaaa ggaagaagta gaagtgttgt      3660
tacttgttga tgatatagtg gtaccaccta agtgacacta aaaattcatc aatggaagta      3720
caggtgatta aaactttcag caaagtgacg ggatacaaga gtaactaaaa caaccattag      3780
ccctcctatg taaaaatggc aaacagcttg agaatgaaat aaaagaagca gcagcaatca      3840
caatagcttc aaataatata aaatacattc tagtaactct aacttgttta attaaaaaaa      3900
ctttaagtgt ttgaagaaag aaattgaaga agatatgagg cgatggaaa                  3949

<210>  7
<211>  1128
<212>  DNA
<213>  Chinese hamster

<400>  7
gatcaggagt tcaaggccac actgaggtac acgaaattca accagtctga tagatataag        60
agctgggtgc gtgtggctcg cacctcaggt ggagacagga gtataaggct ggaggaggca       120
gtatttaggc ttattcatat agaggatttg taaagacagg acctccccag cacttccatc       180
tgaacatttg gtacaggtaa gaagtcccta tagagttggc tcctttaatt ctcttatgtc       240
tcaacattta cccaattatc tgacatctca ctcagcgttt ttactattta aaccaatttg       300
aagaaatgct acagagcacc ttttaacctc tacaaacaca cataaacaca gagagagaga       360
gagagagaga gagagagaga gagagagaga cagagacaga gacagagaca gagacagaga       420
cagagaaaca aatgtaataa cgaaagaagt catgtcatga gaaccctgag gctgcggtcc       480
acacccatct gtggccagga cacagaggcc tagaggagcc ctgtgacaca agcactctct       540
acaactggcc cttgtcccgt gcagggggca gaaaggacag attttgttgt gcagaagctt       600
tatcatcagc agcatacact gggcctctct gtccttcact gtcacatgct cctagggagt       660
tcagtcggga ggtcatgtat gtgcactatg gacctgtccc acagacactc tgtcctaatg       720
cgttctgctg gggtattttg gcaatgctgc aattgagcag tgatgtttca aggtgcacta       780
gttgttcccc ccatattctc caacacaatc aatgccacat tgtaaatcaa aacattcagg       840
ctcccctgtg aattgtaagg attttattat tggaatcctg gttttagata cctggagggt       900
agggtagggc ttgcttcatc tattcaggtg tgtaggcaag tggctccctt gagtcttatt       960
gcccagatgg attcatcaac agaatttgtt agcatctatt ttctgctgca aagagaaccc      1020
ggtgaggtat ctgaggtgtc agaggtgaag gacatctcac tgagcataca tgggacacct      1080
catgggaggg actgaaacct gtctgccaga gcacctgggt ctgaccat                   1128

<210>  8
<211>  1352
<212>  DNA
<213>  Chinese hamster

<400>  8
gatctctcag cttcctgctt tttaaaagta ttttatttta tttttatacc cattgatgtt        60
ttttgtcgtg ggtgtcggat accctgaaac tggaggtttt cattttatat ttatgttaat       120
caatgttttg ccatgggtgt tgcgtcccct gaaactggag ctacagacag gtgtgagctg       180
ccatgtgggg ctgggaactg aacttgagtc ctctggaaga ggagtcagtg ctcttaacta       240
gtgagccatc tctctaggcc ctcagcttcc tgctttggct accagctgac atgcctctcc       300
caccattatg aatgccccct caggaacctc tggaactgaa aaccaaaata aactttttaa       360
agttgcttta gttcatggca ttttatcaca acaatagaca agaaactaat acagtaatac       420
atggcttttt aaatgatttg acagattcat gtaagtatat agtgaatttg ggtcattttt       480
caccctttaa taccattgtc atcctccttc ctaaccagct gggaccctct tcctcagcag       540
gccctcttct actttcattt tttttttttt tttttgtgtg tgtgtgtgtg tgtgtgtgta       600
tgtgtgctcg cgcgtgtgct gtgtccttat gtttatttat ataaaaaata gcgcattgac       660
tctaactttt actacacctt actggttata tatgtatgtg tatgccatgg tacatgtgca       720
gagaacaaag gacaactttc cgggagtcat ttctatcctt ccactatgca tgtggtttct       780
gggatagaac tcaggtcatt agccttggca gcaagcctct taaccctctg aaccatctcc       840
ctggcctggc attttaaaat aatctttgat gcttctatca gtatcttggc cactgataat       900
ctataattat ttctctaaga ctatttgttt tccacaaaca aaatgctata agctgggaga       960
tttataaaga agagatacat ttggctcaca gctctggaaa ctgggaagtc caaaagcatg      1020
acaccagcag ctgtcaaatg cctttctgca gtatcataag aaatcagagg acagcacatg      1080
acaagaatgt tacaaaagga caggacaagt gttccaggct tggtctatgg ttttcatcat      1140
ttaaggccgc caattccatc acaagtgttc tcttccctat gatttcatgt aattctaaag      1200
acattctaaa accccacacc caaatactat tagcacaaga cattggagat tttagtttca      1260
atcttagctt taggggagag acactcagtt cataacagta tccccaagat ttccagtatc      1320
cagtgctgtc tcaatgcaat actactcaga ag                                    1352

<210>  9
<211>  1246
<212>  DNA
<213>  Chinese hamster

<400>  9
gatctttcca ttttctggta tcttctttaa tttctttctt ttaagactca aagttcttgc        60
tagacaggtc tttcacttgt ttggttatca ttaccccaag atattttatg ttgtttggct       120
attgtaaagg atgatgtttc tctgatttat ttctcagccc atttatctcc tgtgtataat       180
agggctagtg attttttgag ttaatcttgt atccttccac ttagctgaag gtgtttatca       240
gctgtagtag ttccctggta gagttttttg ggttacttat gtaactatca tatcatctgc       300
aaacagtaaa aatttgactt cttcctttcc aatttgtatc cccttgttct cctttttgtt       360
gtcatattgc cccagataga acttcaagta caagcagaag tcattctctt ctgcttcatc       420
tgtgttggga tgttcaggtc ttgctggcgt agagtcccta gattctagtg gtgtcatatt       480
gttttttctg ttattgaatg cgtttttata ttgttgtctt cccatctctt cttccagtgg       540
gttcaggtgc cgtctcttcc tctcctggtg tgtatgggtc caaggttctc tttggtggat       600
gcaagagggt ctgatactct gatgggtctt atggtgggtt caggcgggtc tggggcactc       660
cctctctagg tgggggtggg aactggacta gcacagtgat gtcatcagac ttgaggttgc       720
ttggtcctca gggggcaagt tgatttgcct gcagtcccca ggacaggagt tcccagagtg       780
gacaggcaga agtcgggctc aaggcagggg ccaagctcta catgtgattt ttaaaatgag       840
agttcagatt catgtaggca gatgataagc tcagggagag aaatgaccta tttctaaaaa       900
ctgatgacgt gaagattgag agaaagggtg gatttttgaa aaagaatcgg tagggagcta       960
aaaaggaaaa gagaaattaa ggatgactct caggttttgg acttgaatgt tggatggatg      1020
tttgtcccat ttgtagaaag gagaacacag gtgatttaga agtctgaggt gaggatgtca      1080
cctcatgact taaagaatct gaggttttag aatcaaatct cagggaacat cattagcaga      1140
gggaccctgt tgggtcttgc cagatgctga gcttcagctg tctcctgttt tcccacattt      1200
cctgtttttc ctaacttgta tagactctgg gaaaagaagg taccag                     1246

<210>  10
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  10
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr Pro Arg Asp 
    210                 215                 220                 
Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
225                 230                 235                 240 
Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
                245                 250                 255     
Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
        275                 280                 285             
Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
    290                 295                 300                 
Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
305                 310                 315                 320 
Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
            340                 345                 350         
Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
        355                 360                 365             
Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
    370                 375                 380                 
Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
385                 390                 395                 400 
Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
                405                 410                 415     
Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
            420                 425                 430         
His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445         

<210>  11
<211>  451
<212>  PRT
<213>  Artificial Sequence

<400>  11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210>  12
<211>  214
<212>  PRT
<213>  Artificial Sequence

<400>  12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

