
                                SEQUENCE LISTING

<110> Regeneron Pharmaceuticals, Inc.
      

<120> A Pharmaceutical Composition for Safe and Effective Treatment of Knee and/or Hip Pain

<130> REGN-028WO

<140> TBA (Filed Herewith)
<141> TBA

<150> 62/717,435
<151> 2018-08-10

<150> 62/764,816
<151> 2018-08-15

<160> 18

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 1
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg tttccggatt caccctcact gaattatcca ttcactgggt gcgacaggct 120
cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatggtga aacaatctac 180
gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac 240
atggagctga ccagcctgag atcggaagac acggccgtgt attactgttc aacgattttt 300
ggagtggtta ccaactttga caactggggc cagggaaccc tggtcaccgt ctcctca    357

<210> 2
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 2
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Val Ser Gly Phe Thr Leu Thr Glu Leu
            20                  25                  30          
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Thr Ile Phe Gly Val Val Thr Asn Phe Asp Asn Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 3
ggattcaccc tcactgaatt atcc                                        24

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 4
Gly Phe Thr Leu Thr Glu Leu Ser
 1               5              


<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 5
tttgatcctg aagatggtga aaca                                        24

<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 6
Phe Asp Pro Glu Asp Gly Glu Thr
 1               5              


<210> 7
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 7
tcaacgattt ttggagtggt taccaacttt gacaac                           36

<210> 8
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 8
Ser Thr Ile Phe Gly Val Val Thr Asn Phe Asp Asn
 1               5                  10          


<210> 9
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 9
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgcaggaga cagagtcacc 60
atcacttgcc gggcaagtca ggccattaga aatgatttag gctggtatca gcagaaacca 120
gggaaagccc ctaagcgcct gatctatgct gcattcaatt tgcaaagtgg ggtcccatca 180
agattcagcg gcagtggatc tgggacagaa ttcactctca caatcagtag cctgcagcct 240
gaagatcttg caagttatta ctgtcaacag tataatagat acccgtggac gttcggccaa 300
gggaccaagg tggaaatcaa acga                                        324

<210> 10
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ala Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Arg Asn Asp
            20                  25                  30          
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
        35                  40                  45              
Tyr Ala Ala Phe Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Leu Ala Ser Tyr Tyr Cys Gln Gln Tyr Asn Arg Tyr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 11
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 11
caggccatta gaaatgat                                               18

<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 12
Gln Ala Ile Arg Asn Asp
 1               5      


<210> 13
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 13
gctgcattc                                                         9

<210> 14
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 14
Ala Ala Phe
 1          


<210> 15
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 15
caacagtata atagataccc gtggacg                                     27

<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 16
Gln Gln Tyr Asn Arg Tyr Pro Trp Thr
 1               5                  


<210> 17
<211> 847
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 17
agcgtccgga cccaataaca gttttaccaa gggagcagct ttctatcctg gccacactga 60
ggtgcatagc gtaatgtcca tgttgttcta cactctgatc acagcttttc tgatcggcat 120
acaggcggaa ccacactcag agagcaatgt ccctgcagga cacaccatcc cccaagccca 180
ctggactaaa cttcagcatt cccttgacac tgcccttcgc agagcccgca gcgccccggc 240
agcggcgata gctgcacgcg tggcggggca gacccgcaac attactgtgg accccaggct 300
gtttaaaaag cggcgactcc gttcaccccg tgtgctgttt agcacccagc ctccccgtga 360
agctgcagac actcaggatc tggacttcga ggtcggtggt gctgccccct tcaacaggac 420
tcacaggagc aagcggtcat catcccatcc catcttccac aggggcgaat tctcggtgtg 480
tgacagtgtc agcgtgtggg ttggggataa gaccaccgcc acagacatca agggcaagga 540
ggtgatggtg ttgggagagg tgagcattaa caacagtgta ttcaaacagt acttttttga 600
gaccaagtgc cgggacccaa atcccgttga cagcgggtgc cggggcattg actcaaagca 660
ctggaactca tattgtacca cgactcacac ctttgtcaag gcgctgacca tggatggcaa 720
gcaggctgcc tggcggttta tccggataga tacggcctgt atgtgtgtgc tcagcaggaa 780
ggctgtgaga agagcctgac ctgccgacac gctccctccc cctgcccctt ctacactctc 840
ctgggcc                                                           847

<210> 18
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 18
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Val Ser
 1               5                  10                  15      
Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu
            20                  25                  30          
Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln
        35                  40                  45              
Tyr Phe Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro Val Asp Ser Gly
    50                  55                  60                  
Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys Thr Thr Thr
65                  70                  75                  80  
His Thr Phe Ala Leu Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Phe
                85                  90                  95      
Ile Arg Ile Asp Thr Ala Cys Val Cys Val Leu Ser Arg Lys Ala Val
            100                 105                 110         
Arg Arg Ala
        115 

