                         SEQUENCE LISTING

<110>  Cedars-Sinai Medical Center
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCER AND AUTOIMMUNE 
       DISEASES

<130>  13500-04PCT2

<150>  62/716,101
<151>  2018-08-08

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  agonist to GITR/GITRL

<400>  1

Gly Ala Met Ala Ser Gln Leu Glu Thr Ala Lys Glu Pro Cys Met Ala 
1               5                   10                  15      


Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro 
            20                  25                  30          


Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn 
        35                  40                  45              


Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn 
    50                  55                  60                  


Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile 
65                  70                  75                  80  


Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr 
                85                  90                  95      


Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His 
            100                 105                 110         


Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn 
        115                 120                 125             


Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser Lys Glu Pro 
    130                 135                 140                 


Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser 
145                 150                 155                 160 


Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile 
                165                 170                 175     


Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala 
            180                 185                 190         


Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys 
        195                 200                 205             


Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly 
    210                 215                 220                 


Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn 
225                 230                 235                 240 


Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu 
                245                 250                 255     


Leu Ala Asn Pro Gln Phe Ile Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            260                 265                 270         


Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln 
        275                 280                 285             


Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys 
    290                 295                 300                 


Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala 
305                 310                 315                 320 


Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr 
                325                 330                 335     


Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln 
            340                 345                 350         


Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu 
        355                 360                 365             


Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly 
    370                 375                 380                 


Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
385                 390                 395 


<210>  2
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  agonist of GITR/GITRL

<400>  2

Thr Gly Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Phe 
1               5                   10                  15      


Asp Thr Thr Arg Val Tyr Leu Val Asp Asn Lys Ser Thr Asp Val Ala 
            20                  25                  30          


Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Ile 
        35                  40                  45              


Gln Asn Asn Asp Tyr Ser Pro Gly Glu Ala Ser Thr Gln Thr Ile Asn 
    50                  55                  60                  


Leu Asp Asp Arg Ser His Trp Gly Gly Asp Leu Lys Thr Ile Leu His 
65                  70                  75                  80  


Thr Asn Met Pro Asn Val Asn Glu Phe Met Phe Thr Asn Lys Phe Lys 
                85                  90                  95      


Ala Arg Val Met Val Ser Arg Ser Leu Thr Lys Asp Lys Gln Val Glu 
            100                 105                 110         


Leu Lys Tyr Glu Trp Val Glu Phe Thr Leu Pro Glu Gly Asn Tyr Ser 
        115                 120                 125             


Glu Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Val Glu His Tyr 
    130                 135                 140                 


Leu Lys Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val 
145                 150                 155                 160 


Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Phe Asp Pro Val Thr Gly 
                165                 170                 175     


Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile 
            180                 185                 190         


Ile Leu Leu Pro Gly Cys Gly Val Asp Phe Thr His Ser Arg Leu Ser 
        195                 200                 205             


Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Arg 
    210                 215                 220                 


Ile Thr Tyr Asp Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp 
225                 230                 235                 240 


Val Asp Ala Tyr Gln Ala Ser Leu Lys Asp Asp Thr Glu Gln Gly Gly 
                245                 250                 255     


Asp Gly Ala Gly Gly Gly Asn Asn Ser Gly Ser Gly Ala Glu Glu Asn 
            260                 265                 270         


Ser Asn Ala Ala Ala Ala Ala Met Gln Pro Val Glu Asp Met Asn Asp 
        275                 280                 285             


His Ala Ile Asn Gly Ser Thr Phe Ala Thr Arg Ala Glu Glu Lys Arg 
    290                 295                 300                 


Ala Glu Ala Glu Ala Ala Ala Glu Ala Ala Ala Pro Ala Ala Gln Pro 
305                 310                 315                 320 


Glu Val Glu Lys Pro Gln Lys Lys Pro Val Ile Lys Pro Leu Thr Glu 
                325                 330                 335     


Asp Ser Lys Lys Arg Ser Tyr Asn Leu Ile Ser Asn Asp Ser Thr Phe 
            340                 345                 350         


Thr Gln Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Gln 
        355                 360                 365             


Thr Gly Ile Arg Ser Trp Thr Leu Leu Cys Thr Pro Asp Val Thr Cys 
    370                 375                 380                 


Gly Ser Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro 
385                 390                 395                 400 


Val Thr Phe Arg Ser Thr Ser Gln Ile Ser Asn Phe Pro Val Val Gly 
                405                 410                 415     


Ala Glu Leu Leu Pro Val His Ser Lys Ser Phe Tyr Asn Asp Gln Ala 
            420                 425                 430         


Val Tyr Ser Gln Leu Ile Arg Gln Phe Thr Ser Leu Thr His Val Phe 
        435                 440                 445             


Asn Arg Phe Pro Glu Asn Gln Ile Leu Ala Arg Pro Pro Ala Pro Thr 
    450                 455                 460                 


Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr 
465                 470                 475                 480 


Leu Pro Leu Arg Asn Ser Ile Gly Gly Val Gln Arg Val Thr Ile Thr 
                485                 490                 495     


Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile 
            500                 505                 510         


Val Ser Pro Arg Val Leu Ser Ser Arg Thr Gly Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Ser Gly Ala Met Ala Ser Gln Leu Glu Thr Ala Lys Glu Pro Cys 
    530                 535                 540                 


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
545                 550                 555                 560 


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
                565                 570                 575     


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
            580                 585                 590         


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
        595                 600                 605             


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
    610                 615                 620                 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
625                 630                 635                 640 


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
                645                 650                 655     


Ala Asn Pro Gln Phe Ile Ser Gly Ser His His His His His His 
            660                 665                 670     


<210>  3
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild type GITRL

<400>  3

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80  


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95      


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110         


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125             


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140                 


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175     


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190         


Ala Asn Pro Gln Phe Ile Ser 
        195                 


<210>  4
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  agonist to GITR/GITRL

<400>  4

Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln 
1               5                   10                  15      


Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys 
            20                  25                  30          


Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala 
        35                  40                  45              


Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr 
    50                  55                  60                  


Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln 
65                  70                  75                  80  


Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu 
                85                  90                  95      


Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly 
            100                 105                 110         


Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
        115                 120             


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  5

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


