
                                SEQUENCE LISTING

<110> Archer Daniels Midland Company

<120> EPIMERASE ENZYMES AND THEIR USE
  

<130> 008200.00058

<140>
<141>

<150> US 62/716,204
<151> 2018-08-08

<160> 100

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5120
<212> DNA
<213> Artificial Sequence

<220> 
<223> cassette

<400> 1
taagatgaaa aacgctgaca ttgactgggg acaggtcagt gaccagctag ataaagcgaa      60
agataagatt acgaaattca tagaatcaga tgaaggcaaa aacttcatcc agaaagtcat     120
tgatttcttc gtatctatct ggaatgcgat tgtatctata ttcaaataag aaaagcgccg     180
aaaaatcggc gtttctttta ttgctttaca cccgttttaa atggcagatc aagttttaca     240
atatcttcgt atgtttctcg cttcacgact aaatgagcct caccgttttc gacaaataca     300
acggcgggtc tcggaatacg gttataattg ttggccatgc tgtatccata agcgcctgta     360
caaaaaacgg caagaagatc gccttctttt acttccggca ggtcaatatc ccaaatcagc     420
atatctccgc tttcacagca ctttccggca attgataccg ttttgtcatg cgcttctccg     480
atcctgttgg ctgccgcagc ttcatattta gcttggtaaa gcgcaggacg aatattgtcg     540
ttcatgcctc cgtctacagc cacatattgg cggacacccg gcacttcttt ttgagagcca     600
accgtataaa gagttgtgcc tgcgtctccc acgagagaac ggcccggttc gatccaaatt     660
tccggaatgt caaaaccgta acgggaagca ttttctttca gcatgcttaa gttattggta     720
tgactggttt taagcgcaaa aaaagttgct ttttcgtacc tattaatgta tcgttttaga     780
aaaccgactg taaaaagtac agtcggcatt atctcatatt ataaaagcca gtcattaggc     840
ctatctgaca attcctgaat agagttcata aacaatcctg catgataacc atcacaaaca     900
gaatgatgta cctgtaaaga tagcggtaaa tatattgaat tacctttatt aatgaatttt     960
cctgctgtaa taatgggtag aaggtaatta ctattattat tgatatttaa gttaaaccca    1020
gtaaatgaag tccatggaat aatagaaaga gaaaaagcat tttcaggtat aggtgttttg    1080
ggaaacaatt tccccgaacc attatatttc tctacatcag aaaggtataa atcataaaac    1140
tctttgaagt cattctttac aggagtccaa ataccagaga atgttttaga tacaccatca    1200
aaaattgtat aaagtggctc taacttatcc caataaccta actctccgtc gctattgtaa    1260
ccagttctaa aagctgtatt tgagtttatc acccttgtca ctaagaaaat aaatgcaggg    1320
taaaatttat atccttcttg ttttatgttt cggtataaaa cactaatatc aatttctgtg    1380
gttatactaa aagtcgtttg ttggttcaaa taatgattaa atatctcttt tctcttccaa    1440
ttgtctaaat caattttatt aaagttcatt tgatatgcct cctaaatttt tatctaaagt    1500
gaatttagga ggcttacttg tctgctttct tcattagaat caatcctttt ttaaaagtca    1560
atattactgt aacataaata tatattttaa aaatatccca ctttatccaa ttttcgtttg    1620
ttgaactaat gggtgcttta gttgaagaat aaagaccaca ttaaaaaatg tggtcttttg    1680
tgttttttta aaggatttga gcgtagcgaa aaatcctttt ctttcttatc ttgataataa    1740
gggtaactat tgccgatcgt ccattccgac agcatcgcca gtcactatgg cgtgctgcta    1800
gcgccattcg ccattcaggc tgcgcaactg ttgggaaggg cgatcggtgc gggcctcttc    1860
gctattacgc cagctggcga aagggggatg tgctgcaagg cgattaagtt gggtaacgcc    1920
agggttttcc cagtcacgac gttgtaaaac gacggccagt gaattcgagc tcaggcctta    1980
actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    2040
gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgccaggg    2100
tggtttttct tttcaccagt gagacgggca acagctgatt gcccttcacc gcctggccct    2160
gagagagttg cagcaagcgg tccacgctgg tttgccccag caggcgaaaa tcctgtttga    2220
tggtggttga cggcgggata taacatgagc tgtcttcggt atcgtcgtat cccactaccg    2280
agatatccgc accaacgcgc agcccggact cggtaatggc gcgcattgcg cccagcgcca    2340
tctgatcgtt ggcaaccagc atcgcagtgg gaacgatgcc ctcattcagc atttgcatgg    2400
tttgttgaaa accggacatg gcactccagt cgccttcccg ttccgctatc ggctgaattt    2460
gattgcgagt gagatattta tgccagccag ccagacgcag acgcgccgag acagaactta    2520
atgggcccgc taacagcgcg atttgctggt gacccaatgc gaccagatgc tccacgccca    2580
gtcgcgtacc gtcttcatgg gagaaaataa tactgttgat gggtgtctgg tcagagacat    2640
caagaaataa cgccggaaca ttagtgcagg cagcttccac agcaatggca tcctggtcat    2700
ccagcggata gttaatgatc agcccactga cgcgttgcgc gagaagattg tgcaccgccg    2760
ctttacaggc ttcgacgccg cttcgttcta ccatcgacac caccacgctg gcacccagtt    2820
gatcggcgcg agatttaatc gccgcgacaa tttgcgacgg cgcgtgcagg gccagactgg    2880
aggtggcaac gccaatcagc aacgactgtt tgcccgccag ttgttgtgcc acgcggttgg    2940
gaatgtaatt cagctccgcc atcgccgctt ccactttttc ccgcgttttc gcagaaacgt    3000
ggctggcctg gttcaccacg cgggaaacgg tctgataaga gacaccggca tactctgcga    3060
catcgtataa cgttactggt ttcatcaaaa tcgtctccct ccgtttgaat atttgattga    3120
tcgtaaccag atgaagcact ctttccacta tccctacagt gttatggctt gaacaatcac    3180
gaaacaataa ttggtacgta cgatctttca gccgactcaa acatcaaatc ttacaaatgt    3240
agtctttgaa agtattacat atgtaagatt taaatgcaac cgttttttcg gaaggaaatg    3300
atgacctcgt ttccaccgga attagcttgg taccaaagga ggtaaggatc actagaaaat    3360
tttttaaaaa atctcttgac attggaaggg agatatgtta ttataagaat tgcggaattg    3420
tgagcggata acaattccca tataaaggag gaaggatcca tgaataagtt aggtgtgcac    3480
gcattagttt gggaagcggg ttggagtcgt gatgagtgtg ctcgtgccat cgcacgcacc    3540
gcggaaacgg gatttgactt cattgaagtc ccagcgttag atccggcaag cattgatgca    3600
gagtttactc gcagagagtt agaacgccat gggttgggag taaccttttc gcttggactc    3660
gatgcgcaaa cagacattag ttctggtgat ccggaacgcg cagcgcgggg taaagctaaa    3720
ttagacgatg tcttacgtgt agcccgggat tgtggagcga ctcatgtctg tggaattctc    3780
tatagtgcat ttcaaaaaaa tgcagttcct acgacccgtg cgggtgtcgc catggccgcg    3840
gacattttag gacaggtagc tgatactgca gcacaatacg gtattacttt ggggttagaa    3900
gtcgttaacc gttatgagtc aaatgtattg aacaccgcgt cacagggtgt tgaactttgc    3960
gagcgtattg gtcgtcccaa cgtaaaagtg catttagata cgtatcacat gaatattgaa    4020
gagagcgata ttatgagcgc gatcagagat acgggagaca ggctagggta tttccatatt    4080
ggcgattctc atcgtggtta cctgggttcc ggaaacgtcg actttactgc cgtatttagg    4140
gcgctggtat tttctggata tacgggaccg attacatttg agtcattctc cagtagagtc    4200
gtaggacaac cattagaggg aattctggca atttggcgta atttatggga agattcccgc    4260
gatctagcta gtcacgcctt agcatatact cgtgtccagt taaaatctgc tcaagaagcc    4320
ctaaaacaag ccgagcgcag tcgcttaccg tgataacccg ggcagcccgc ctaatgagcg    4380
ggcttttttc acgtcacgcg tccatggaga tctaagcttt cactttttgc ttcagggttt    4440
cagccgtatg gtgatcgagt tcgcctgtta atcgaataca aagcacagat tctttgacat    4500
tcatgtcaat tccaaggctc atgctcattc ctccttgata tgatcggata atgagtgttt    4560
cgatttcgac ggaatgaatt ccttcaccgt gacaaaacta gtggtcattc ggcataatta    4620
cttaaatttt gtccagtctc ccatcgtccg ctttaagaat gtgataaacc cggctttctt    4680
catatcttct tttgcagcaa caggactttc agcgagtact tctccatcct ttttcagaac    4740
aagagtgcca agctcttggc ctttttgaat cggagcacta atattgtcct tcatcttgat    4800
ttcttttttc acatcgttca tatcctcgcc ttttttcgtc aatattgaaa tcggctcaga    4860
tgtagtgagt tcgataaatt tttgtttccc ttttttgacc tttacttttg ctactgtttg    4920
atttcgttta tataaaggat gcgtttcata ttggctaaag gcgaagtcaa gcatttttgt    4980
cacttgcgcg tttctttctt taggcgtgct cgctccgaat acaaccgcta tggcccgcat    5040
gtttcctttt ttagccgaag cagtcagaca atatttcgct tcgcctgtat agcctgtttt    5100
tacgccgtct acaccaggat                                                5120



<210> 2
<211> 1925
<212> DNA
<213> Artificial Sequence

<220> 
<223> cassette

<400> 2
ttattgcttt acacccgttt taaatggcag atcaagtttt acaatatctt cgtatgtttc      60
tcgcttcacg actaaatgag cctcaccgtt ttcgacaaat acaacggcgg gtctcggaat     120
acggttataa ttgttggcca tgctgtatcc ataagcgcct gtacaaaaaa cggcaagaag     180
atcgccttct tttacttccg gcaggtcaat atcccaaatc agcatatctc cgctttcaca     240
gcactttccg gcaattgata ccgttttgtc atgcgcttct ccgatcctgt tggctgccgc     300
agcttcatat ttagcttggt aaagcgcagg acgaatattg tcgttcatgc ctccgtctac     360
agccacatat tggcggacac ccggcacttc tttttgagag ccaaccgtat aaagagttgt     420
gcctgcgtct cccacgagag aacggcccgg ttcgatccaa atttccggaa tgtcaaaacc     480
gtaacgggaa gcattttctt tcacagcttc gataattttt tcaacgtatt cagtggcatg     540
aagcggttca tcatcttccg tataacgaat gccgaaacct cctccaagat tcagcacctt     600
ggatacaaat gaatatgaat ctctccattc gtctagtttt ttgaagattt tttccgctgc     660
taacacaaaa ccggccgtat caaagatttg cgagccgata tggcaatgga cacccagcag     720
ctgaatgtgt tccgattgta atacttgttc aatggcccgt tcagtttgtc cgttatgaag     780
atcgaaacca aactttgaat cttcctggcc cgttgtaatg tagtcatgcg tatgcgcttc     840
tactccgggc gtgatccgaa gaagaacatc gatggagtga cccgtttctt tacataggtc     900
ttcaagaagc gcgatttcat agaaattatc caccacaatg cagccgatgc ggtgctcaag     960
cgccatccgc agttcttccc tgctcttatt gtttccatga aagtggatgc gttctgccgg    1020
aaagcctgct gcaacagccg tatatagctc tcctccggat acgacatcta aagaaagtcc    1080
ctcttcctca gcgagctgaa tcattgcgac tgatgagaat gctttgctcg catatgccac    1140
ctgtgctttc agccctgcag aaataaacgc ctgcttaaag cttttagcac gctcacgtat    1200
taaagccaca tcatatacgt aaagaggtgt accatatttc tccgctaaat agagagcatc    1260
cacacctccg atttctaaat gaccatgttg attttgtctg cttgtgccgt gtaagaacaa    1320
tgtcattccc tctttctccg cttatggatg aaaggacagt tttatggact gtcccttcat    1380
aattaagaca tacattatca tactcttcag tcagtttcaa tgcgatcact gcccgctttc    1440
cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc    1500
ggtttgcgta ttgggcgcca gggtggtttt tcttttcacc agtgagacgg gcaacagctg    1560
attgcccttc accgcctggc cctgagagag ttgcagcaag cggtccacgc tggtttgccc    1620
cagcaggcga aaatcctgtt tgatggtggt tgacggcggg atataacatg agctgtcttc    1680
ggtatcgtcg tatcccacta ccgagatatc cgcaccaacg cgcagcccgg actcggtaat    1740
ggcgcgcatt gcgcccagcg ccatctgatc gttggcaacc agcatcgcag tgggaacgat    1800
gccctcattc agcatttgca tggtttgttg aaaaccggac atggcactcc agtcgccttc    1860
ccgttccgct atcggctgaa tttgattgcg agtgagatat ttatgccagc cagccagacg    1920
cagac                                                                1925

<210> 3
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 3
ttattgcttt acacccgttt taaatgg                                          27

<210> 4
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 4
tctcactcgc aatcaaattc agccg                                            25

<210> 5
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> codon optimized sequence for xylose isomerase
      [Burkholderia multivorans CGD1]

<400> 5
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attagacgat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgagt caaatgtatt gaacaccgcg     480
tcacagggtg ttgaactttg cgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 6
<211> 297
<212> PRT
<213> Burkholderia multivorans

<400> 6
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 7
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 230323

<400> 7
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaaat tccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcggcag gtaaagctaa attagacgat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaactttg cgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 8
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 230323

<400> 8
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Ile Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp His Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser Asn Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 9
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 230329

<400> 9
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaaat tccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attagacgat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 10
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 230329

<400> 10
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Ala Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser His Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Ala Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 11
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 230333

<400> 11
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcggcag gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgagt caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 12
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 230333

<400> 12
Met Asn Lys Phe Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Leu His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Pro Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 13
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 230335

<400> 13
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcggcag gtaaagctaa attagacgat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 14
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 230335

<400> 14
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Val Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Glu Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Leu Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 15
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 230338

<400> 15
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 16
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 230338

<400> 16
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Gly Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Leu Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Ile Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 17
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 256407

<400> 17
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca ctgcaaaaat atgcagttcc tacgaccgca     360
gatggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 18
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 256407

<400> 18
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Lys Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Leu Gln
            100                 105                 110
Lys Tyr Ala Val Pro Thr Thr Ala Asp Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Thr Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Ile Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 19
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 230339

<400> 19
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaactttg cgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattgttttt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 20
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 230339

<400> 20
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Ser Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Glu Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Thr Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 21
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 248843

<400> 21
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca ctgcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattccgc agatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 22
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 248843

<400> 22
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Phe His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Ile Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Ile
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 23
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 248867

<400> 23
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta agacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggatca     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 24
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 248867

<400> 24
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Glu Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Val
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Val Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 25
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 248891

<400> 25
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcta tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atcaaggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgcacag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 26
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 248891

<400> 26
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ala Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Asp Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Cys Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 27
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 248907

<400> 27
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcta tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta agacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 28
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 248907

<400> 28
Met Asn Lys Leu Gly Val His Ala Leu Leu Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Ile Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Arg Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 29
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 248914

<400> 29
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattatgt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 30
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 248914

<400> 30
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Tyr
            20                  25                  30
Asp Phe Ile Glu Leu Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Glu Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 31
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 248925

<400> 31
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agattttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgaccgca     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggatca     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 32
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 248925

<400> 32
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Glu Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Met
225                 230                 235                 240
Glu Ala Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 33
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 256382

<400> 33
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaata tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca ctgcaaaaaa atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta agacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 34
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 256382

<400> 34
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Tyr
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp His Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Leu Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 35
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 256406

<400> 35
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacgtta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 36
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 256406

<400> 36
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Pro Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Val His Ile Gly
        195                 200                 205
Asp Ser Asn Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 37
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 255290

<400> 37
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 38
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 255290

<400> 38
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Thr Tyr Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Leu
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 39
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 257999

<400> 39
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 40
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 257999

<400> 40
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Gly Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Leu Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Ile
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 41
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261731

<400> 41
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 42
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261731

<400> 42
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp His Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Pro Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Pro Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 43
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261732

<400> 43
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 44
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261732

<400> 44
Met Asn Lys Leu Gly Val His Ala Leu Leu Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Pro Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Val His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 45
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261733

<400> 45
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 46
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261733

<400> 46
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ala Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Ile Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Pro Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 47
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261734

<400> 47
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 48
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261734

<400> 48
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 49
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261735

<400> 49
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 50
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261735

<400> 50
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Ser Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Glu Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Leu
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 51
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261736

<400> 51
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 52
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261736

<400> 52
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Pro Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val Leu Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Ile Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 53
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261737

<400> 53
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 54
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261737

<400> 54
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Ser Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Phe Glu Ser Asn Leu Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 55
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261738

<400> 55
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 56
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261738

<400> 56
Met Asn Lys Ile Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Glu Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Pro Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 57
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261739

<400> 57
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 58
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261739

<400> 58
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Gly Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Asp Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val Leu Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 59
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261740

<400> 59
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 60
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261740

<400> 60
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Ile Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Ser Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Leu Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 61
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261741

<400> 61
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 62
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261741

<400> 62
Met Asn Lys Phe Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Phe His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Arg Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 63
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261742

<400> 63
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 64
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261742

<400> 64
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Leu Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Gly Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Ala Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 65
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261743

<400> 65
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 66
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261743

<400> 66
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Pro Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Ile Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Trp Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 67
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261744

<400> 67
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 68
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261744

<400> 68
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Pro Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Leu Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Glu Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 69
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261745

<400> 69
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 70
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261745

<400> 70
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Pro Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser His Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Trp Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 71
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261746

<400> 71
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agattttact cgcagagagt tagaaaaata tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 72
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261746

<400> 72
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Gly Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Leu Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Arg Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 73
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261747

<400> 73
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccgagaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 74
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261747

<400> 74
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Leu Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Ala Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Leu Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 75
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261748

<400> 75
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaata tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcacg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 76
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261748

<400> 76
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Tyr Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Leu Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Val
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 77
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261749

<400> 77
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccgagaa gcattgatgc agagtttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcacg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 78
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261749

<400> 78
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Leu His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Ile Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Leu
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 79
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261750

<400> 79
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccgagaa gcattgatgc agattttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 80
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261750

<400> 80
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Val Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Val Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Gly Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 81
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261751

<400> 81
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agattttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgaatct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatttac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 82
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261751

<400> 82
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Thr Gly His Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Leu Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 83
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261752

<400> 83
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccgagaa gcattgatgc agattttact cgcagagagt tagaaaaaca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagatggccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 84
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261752

<400> 84
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Phe Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Leu Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Leu Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 85
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261753

<400> 85
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaata tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa tgcgacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgacccgt     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcacg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 86
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261753

<400> 86
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Leu Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Val Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Leu Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 87
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 261754

<400> 87
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaaaaata tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaat atgcagttcc tacgaccgca     360
agaggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacggcagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcacg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 88
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 261754

<400> 88
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Met
225                 230                 235                 240
Glu Cys Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Val Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 89
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 277285

<400> 89
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgagt caaatgtatt gaacaccgcg     480
tcacagggtg ttgaactttg cgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 90
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 277285

<400> 90
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Lys Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 91
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 277286

<400> 91
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attagacgat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaactttg cgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 92
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 277286

<400> 92
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Thr Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 93
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 277287

<400> 93
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attagacgat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgagt caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 94
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 277287

<400> 94
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Ile Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 95
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 277288

<400> 95
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaactttg cgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 96
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 277288

<400> 96
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Lys Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Thr Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Cys Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 97
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 277289

<400> 97
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attagacgat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgaga caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 98
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 277289

<400> 98
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Asp Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Thr Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Ile Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295

<210> 99
<211> 897
<212> DNA
<213> Artificial Sequence

<220> 
<223> coding sequence for variant 277290

<400> 99
atgaataagt taggtgtgca cgcattagtt tgggaagcgg gttggagtcg tgatgagtgt      60
gctcgtgcca tcgcacgcac cgcggaaacg ggatttgact tcattgaagt cccagcgtta     120
gatccggcaa gcattgatgc agagtttact cgcagagagt tagaacgcca tgggttggga     180
gtaacctttt cgcttggact cgatgcgcaa acagacatta gttctggtga tccggaacgc     240
gcagcgcggg gtaaagctaa attaaaagat gtcttacgtg tagcccggga ttgtggagcg     300
actcatgtct gtggaattct ctatagtgca tttcaaaaaa atgcagttcc tacgacccgt     360
gcgggtgtcg ccatggccgc ggacatttta ggacaggtag ctgatactgc agcacaatac     420
ggtattactt tggggttaga agtcgttaac cgttatgagt caaatgtatt gaacaccgcg     480
tcacagggtg ttgaacttat tgagcgtatt ggtcgtccca acgtaaaagt gcatttagat     540
acgtatcaca tgaatattga agagagcgat attatgagcg cgatcagaga tacgggagac     600
aggctagggt atttccatat tggcgattct catcgtggtt acctgggttc cggaaacgtc     660
gactttactg ccgtatttag ggcgctggta ttttctggat atacgggacc gattacattt     720
gagtcattct ccagtagagt cgtaggacaa ccattagagg gaattctggc aatttggcgt     780
aatttatggg aagattcccg cgatctagct agtcacgcct tagcatatac tcgtgtccag     840
ttaaaatctg ctcaagaagc cctaaaacaa gccgagcgca gtcgcttacc gtgataa        897

<210> 100
<211> 297
<212> PRT
<213> Artificial Sequence

<220> 
<223> variant 277290

<400> 100
Met Asn Lys Leu Gly Val His Ala Leu Val Trp Glu Ala Gly Trp Ser
 1               5                  10                  15
Arg Asp Glu Cys Ala Arg Ala Ile Ala Arg Thr Ala Glu Thr Gly Phe
            20                  25                  30
Asp Phe Ile Glu Val Pro Ala Leu Asp Pro Ala Ser Ile Asp Ala Glu
        35                  40                  45
Phe Thr Arg Arg Glu Leu Glu Arg His Gly Leu Gly Val Thr Phe Ser
    50                  55                  60
Leu Gly Leu Asp Ala Gln Thr Asp Ile Ser Ser Gly Asp Pro Glu Arg
65                  70                  75                  80
Ala Ala Arg Gly Lys Ala Lys Leu Lys Asp Val Leu Arg Val Ala Arg
                85                  90                  95
Asp Cys Gly Ala Thr His Val Cys Gly Ile Leu Tyr Ser Ala Phe Gln
            100                 105                 110
Lys Asn Ala Val Pro Thr Thr Arg Ala Gly Val Ala Met Ala Ala Asp
        115                 120                 125
Ile Leu Gly Gln Val Ala Asp Thr Ala Ala Gln Tyr Gly Ile Thr Leu
    130                 135                 140
Gly Leu Glu Val Val Asn Arg Tyr Glu Ser Asn Val Leu Asn Thr Ala
145                 150                 155                 160
Ser Gln Gly Val Glu Leu Ile Glu Arg Ile Gly Arg Pro Asn Val Lys
                165                 170                 175
Val His Leu Asp Thr Tyr His Met Asn Ile Glu Glu Ser Asp Ile Met
            180                 185                 190
Ser Ala Ile Arg Asp Thr Gly Asp Arg Leu Gly Tyr Phe His Ile Gly
        195                 200                 205
Asp Ser His Arg Gly Tyr Leu Gly Ser Gly Asn Val Asp Phe Thr Ala
    210                 215                 220
Val Phe Arg Ala Leu Val Phe Ser Gly Tyr Thr Gly Pro Ile Thr Phe
225                 230                 235                 240
Glu Ser Phe Ser Ser Arg Val Val Gly Gln Pro Leu Glu Gly Ile Leu
                245                 250                 255
Ala Ile Trp Arg Asn Leu Trp Glu Asp Ser Arg Asp Leu Ala Ser His
            260                 265                 270
Ala Leu Ala Tyr Thr Arg Val Gln Leu Lys Ser Ala Gln Glu Ala Leu
        275                 280                 285
Lys Gln Ala Glu Arg Ser Arg Leu Pro
    290                 295
