                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> METHODS COMPOSITIONS RELATING TO INHIBITING CARDIOVASCULAR 
      CALCIFICATION VIA ANNEXIN A1

<130> 043214-093330WOPT

<140>
<141>

<150> 62/715,428
<151> 2018-08-07

<160> 25    

<170> PatentIn version 3.5

<210> 1
<211> 6656
<212> DNA
<213> Homo sapiens

<400> 1
gcaggtgacc cggaggccct cgccgcccgc ggcgccccga gcgctttgtg agcagatgcg       60

gagccgagtg gagggcgcga gccagatgcg gggcgacagc tgacttgctg agaggaggcg      120

gggaggcgcg gagcgcgcgt gtggtccttg cgccgctgac ttctccactg gttcctgggc      180

accgaaagat aaacctctca taatgaaggc ccccgctgtg cttgcacctg gcatcctcgt      240

gctcctgttt accttggtgc agaggagcaa tggggagtgt aaagaggcac tagcaaagtc      300

cgagatgaat gtgaatatga agtatcagct tcccaacttc accgcggaaa cacccatcca      360

gaatgtcatt ctacatgagc atcacatttt ccttggtgcc actaactaca tttatgtttt      420

aaatgaggaa gaccttcaga aggttgctga gtacaagact gggcctgtgc tggaacaccc      480

agattgtttc ccatgtcagg actgcagcag caaagccaat ttatcaggag gtgtttggaa      540

agataacatc aacatggctc tagttgtcga cacctactat gatgatcaac tcattagctg      600

tggcagcgtc aacagaggga cctgccagcg acatgtcttt ccccacaatc atactgctga      660

catacagtcg gaggttcact gcatattctc cccacagata gaagagccca gccagtgtcc      720

tgactgtgtg gtgagcgccc tgggagccaa agtcctttca tctgtaaagg accggttcat      780

caacttcttt gtaggcaata ccataaattc ttcttatttc ccagatcatc cattgcattc      840

gatatcagtg agaaggctaa aggaaacgaa agatggtttt atgtttttga cggaccagtc      900

ctacattgat gttttacctg agttcagaga ttcttacccc attaagtatg tccatgcctt      960

tgaaagcaac aattttattt acttcttgac ggtccaaagg gaaactctag atgctcagac     1020

ttttcacaca agaataatca ggttctgttc cataaactct ggattgcatt cctacatgga     1080

aatgcctctg gagtgtattc tcacagaaaa gagaaaaaag agatccacaa agaaggaagt     1140

gtttaatata cttcaggctg cgtatgtcag caagcctggg gcccagcttg ctagacaaat     1200

aggagccagc ctgaatgatg acattctttt cggggtgttc gcacaaagca agccagattc     1260

tgccgaacca atggatcgat ctgccatgtg tgcattccct atcaaatatg tcaacgactt     1320

cttcaacaag atcgtcaaca aaaacaatgt gagatgtctc cagcattttt acggacccaa     1380

tcatgagcac tgctttaata ggacacttct gagaaattca tcaggctgtg aagcgcgccg     1440

tgatgaatat cgaacagagt ttaccacagc tttgcagcgc gttgacttat tcatgggtca     1500

attcagcgaa gtcctcttaa catctatatc caccttcatt aaaggagacc tcaccatagc     1560

taatcttggg acatcagagg gtcgcttcat gcaggttgtg gtttctcgat caggaccatc     1620

aacccctcat gtgaattttc tcctggactc ccatccagtg tctccagaag tgattgtgga     1680

gcatacatta aaccaaaatg gctacacact ggttatcact gggaagaaga tcacgaagat     1740

cccattgaat ggcttgggct gcagacattt ccagtcctgc agtcaatgcc tctctgcccc     1800

accctttgtt cagtgtggct ggtgccacga caaatgtgtg cgatcggagg aatgcctgag     1860

cgggacatgg actcaacaga tctgtctgcc tgcaatctac aaggttttcc caaatagtgc     1920

accccttgaa ggagggacaa ggctgaccat atgtggctgg gactttggat ttcggaggaa     1980

taataaattt gatttaaaga aaactagagt tctccttgga aatgagagct gcaccttgac     2040

tttaagtgag agcacgatga atacattgaa atgcacagtt ggtcctgcca tgaataagca     2100

tttcaatatg tccataatta tttcaaatgg ccacgggaca acacaataca gtacattctc     2160

ctatgtggat cctgtaataa caagtatttc gccgaaatac ggtcctatgg ctggtggcac     2220

tttacttact ttaactggaa attacctaaa cagtgggaat tctagacaca tttcaattgg     2280

tggaaaaaca tgtactttaa aaagtgtgtc aaacagtatt cttgaatgtt ataccccagc     2340

ccaaaccatt tcaactgagt ttgctgttaa attgaaaatt gacttagcca accgagagac     2400

aagcatcttc agttaccgtg aagatcccat tgtctatgaa attcatccaa ccaaatcttt     2460

tattagtggt gggagcacaa taacaggtgt tgggaaaaac ctgaattcag ttagtgtccc     2520

gagaatggtc ataaatgtgc atgaagcagg aaggaacttt acagtggcat gtcaacatcg     2580

ctctaattca gagataatct gttgtaccac tccttccctg caacagctga atctgcaact     2640

ccccctgaaa accaaagcct ttttcatgtt agatgggatc ctttccaaat actttgatct     2700

catttatgta cataatcctg tgtttaagcc ttttgaaaag ccagtgatga tctcaatggg     2760

caatgaaaat gtactggaaa ttaagggaaa tgatattgac cctgaagcag ttaaaggtga     2820

agtgttaaaa gttggaaata agagctgtga gaatatacac ttacattctg aagccgtttt     2880

atgcacggtc cccaatgacc tgctgaaatt gaacagcgag ctaaatatag agtggaagca     2940

agcaatttct tcaaccgtcc ttggaaaagt aatagttcaa ccagatcaga atttcacagg     3000

attgattgct ggtgttgtct caatatcaac agcactgtta ttactacttg ggtttttcct     3060

gtggctgaaa aagagaaagc aaattaaaga tctgggcagt gaattagttc gctacgatgc     3120

aagagtacac actcctcatt tggataggct tgtaagtgcc cgaagtgtaa gcccaactac     3180

agaaatggtt tcaaatgaat ctgtagacta ccgagctact tttccagaag atcagtttcc     3240

taattcatct cagaacggtt catgccgaca agtgcagtat cctctgacag acatgtcccc     3300

catcctaact agtggggact ctgatatatc cagtccatta ctgcaaaata ctgtccacat     3360

tgacctcagt gctctaaatc cagagctggt ccaggcagtg cagcatgtag tgattgggcc     3420

cagtagcctg attgtgcatt tcaatgaagt cataggaaga gggcattttg gttgtgtata     3480

tcatgggact ttgttggaca atgatggcaa gaaaattcac tgtgctgtga aatccttgaa     3540

cagaatcact gacataggag aagtttccca atttctgacc gagggaatca tcatgaaaga     3600

ttttagtcat cccaatgtcc tctcgctcct gggaatctgc ctgcgaagtg aagggtctcc     3660

gctggtggtc ctaccataca tgaaacatgg agatcttcga aatttcattc gaaatgagac     3720

tcataatcca actgtaaaag atcttattgg ctttggtctt caagtagcca aaggcatgaa     3780

atatcttgca agcaaaaagt ttgtccacag agacttggct gcaagaaact gtatgctgga     3840

tgaaaaattc acagtcaagg ttgctgattt tggtcttgcc agagacatgt atgataaaga     3900

atactatagt gtacacaaca aaacaggtgc aaagctgcca gtgaagtgga tggctttgga     3960

aagtctgcaa actcaaaagt ttaccaccaa gtcagatgtg tggtcctttg gcgtgctcct     4020

ctgggagctg atgacaagag gagccccacc ttatcctgac gtaaacacct ttgatataac     4080

tgtttacttg ttgcaaggga gaagactcct acaacccgaa tactgcccag accccttata     4140

tgaagtaatg ctaaaatgct ggcaccctaa agccgaaatg cgcccatcct tttctgaact     4200

ggtgtcccgg atatcagcga tcttctctac tttcattggg gagcactatg tccatgtgaa     4260

cgctacttat gtgaacgtaa aatgtgtcgc tccgtatcct tctctgttgt catcagaaga     4320

taacgctgat gatgaggtgg acacacgacc agcctccttc tgggagacat catagtgcta     4380

gtactatgtc aaagcaacag tccacacttt gtccaatggt tttttcactg cctgaccttt     4440

aaaaggccat cgatattctt tgctcttgcc aaaattgcac tattatagga cttgtattgt     4500

tatttaaatt actggattct aaggaatttc ttatctgaca gagcatcaga accagaggct     4560

tggtcccaca ggccacggac caatggcctg cagccgtgac aacactcctg tcatattgga     4620

gtccaaaact tgaattctgg gttgaatttt ttaaaaatca ggtaccactt gatttcatat     4680

gggaaattga agcaggaaat attgagggct tcttgatcac agaaaactca gaagagatag     4740

taatgctcag gacaggagcg gcagccccag aacaggccac tcatttagaa ttctagtgtt     4800

tcaaaacact tttgtgtgtt gtatggtcaa taacattttt cattactgat ggtgtcattc     4860

acccattagg taaacattcc cttttaaatg tttgtttgtt ttttgagaca ggatctcact     4920

ctgttgccag ggctgtagtg cagtggtgtg atcatagctc actgcaacct ccacctccca     4980

ggctcaagcc tcccgaatag ctgggactac aggcgcacac caccatcccc ggctaatttt     5040

tgtatttttt gtagagacgg ggttttgcca tgttgccaag gctggtttca aactcctgga     5100

ctcaagaaat ccacccacct cagcctccca aagtgctagg attacaggca tgagccactg     5160

cgcccagccc ttataaattt ttgtatagac attcctttgg ttggaagaat atttataggc     5220

aatacagtca aagtttcaaa atagcatcac acaaaacatg tttataaatg aacaggatgt     5280

aatgtacata gatgacatta agaaaatttg tatgaaataa tttagtcatc atgaaatatt     5340

tagttgtcat ataaaaaccc actgtttgag aatgatgcta ctctgatcta atgaatgtga     5400

acatgtagat gttttgtgtg tattttttta aatgaaaact caaaataaga caagtaattt     5460

gttgataaat atttttaaag ataactcagc atgtttgtaa agcaggatac attttactaa     5520

aaggttcatt ggttccaatc acagctcata ggtagagcaa agaaagggtg gatggattga     5580

aaagattagc ctctgtctcg gtggcaggtt cccacctcgc aagcaattgg aaacaaaact     5640

tttggggagt tttattttgc attagggtgt gttttatgtt aagcaaaaca tactttagaa     5700

acaaatgaaa aaggcaattg aaaatcccag ctatttcacc tagatggaat agccaccctg     5760

agcagaactt tgtgatgctt cattctgtgg aattttgtgc ttgctactgt atagtgcatg     5820

tggtgtaggt tactctaact ggttttgtcg acgtaaacat ttaaagtgtt atatttttta     5880

taaaaatgtt tatttttaat gatatgagaa aaattttgtt aggccacaaa aacactgcac     5940

tgtgaacatt ttagaaaagg tatgtcagac tgggattaat gacagcatga ttttcaatga     6000

ctgtaaattg cgataaggaa atgtactgat tgccaataca ccccaccctc attacatcat     6060

caggacttga agccaagggt taacccagca agctacaaag agggtgtgtc acactgaaac     6120

tcaatagttg agtttggctg ttgttgcagg aaaatgatta taactaaaag ctctctgata     6180

gtgcagagac ttaccagaag acacaaggaa ttgtactgaa gagctattac aatccaaata     6240

ttgccgtttc ataaatgtaa taagtaatac taattcacag agtattgtaa atggtggatg     6300

acaaaagaaa atctgctctg tggaaagaaa gaactgtctc taccagggtc aagagcatga     6360

acgcatcaat agaaagaact cggggaaaca tcccatcaac aggactacac acttgtatat     6420

acattcttga gaacactgca atgtgaaaat cacgtttgct atttataaac ttgtccttag     6480

attaatgtgt ctggacagat tgtgggagta agtgattctt ctaagaatta gatacttgtc     6540

actgcctata cctgcagctg aactgaatgg tacttcgtat gttaatagtt gttctgataa     6600

atcatgcaat taaagtaaag tgatgcaaca tcttgtaaaa aaaaaaaaaa aaaaaa         6656


<210> 2
<211> 1401
<212> DNA
<213> Homo sapiens

<400> 2
agtgtgaaat cttcagagaa gaatttctct ttagttcttt gcaagaaggt agagataaag       60

acactttttc aaaaatggca atggtatcag aattcctcaa gcaggcctgg tttattgaaa      120

atgaagagca ggaatatgtt caaactgtga agtcatccaa aggtggtccc ggatcagcgg      180

tgagccccta tcctaccttc aatccatcct cggatgtcgc tgccttgcat aaggccataa      240

tggttaaagg tgtggatgaa gcaaccatca ttgacattct aactaagcga aacaatgcac      300

agcgtcaaca gatcaaagca gcatatctcc aggaaacagg aaagcccctg gatgaaacac      360

tgaagaaagc ccttacaggt caccttgagg aggttgtttt agctctgcta aaaactccag      420

cgcaatttga tgctgatgaa cttcgtgctg ccatgaaggg ccttggaact gatgaagata      480

ctctaattga gattttggca tcaagaacta acaaagaaat cagagacatt aacagggtct      540

acagagagga actgaagaga gatctggcca aagacataac ctcagacaca tctggagatt      600

ttcggaacgc tttgctttct cttgctaagg gtgaccgatc tgaggacttt ggtgtgaatg      660

aagacttggc tgattcagat gccagggcct tgtatgaagc aggagaaagg agaaagggga      720

cagacgtaaa cgtgttcaat accatcctta ccaccagaag ctatccacaa cttcgcagag      780

tgtttcagaa atacaccaag tacagtaagc atgacatgaa caaagttctg gacctggagt      840

tgaaaggtga cattgagaaa tgcctcacag ctatcgtgaa gtgcgccaca agcaaaccag      900

ctttctttgc agagaagctt catcaagcca tgaaaggtgt tggaactcgc cataaggcat      960

tgatcaggat tatggtttcc cgttctgaaa ttgacatgaa tgatatcaaa gcattctatc     1020

agaagatgta tggtatctcc ctttgccaag ccatcctgga tgaaaccaaa ggagattatg     1080

agaaaatcct ggtggctctt tgtggaggaa actaaacatt cccttgatgg tctcaagcta     1140

tgatcagaag actttaatta tatattttca tcctataagc ttaaatagga aagtttcttc     1200

aacaggatta cagtgtagct acctacatgc tgaaaaatat agcctttaaa tcatttttat     1260

attataactc tgtataatag agataagtcc attttttaaa aatgttttcc ccaaaccata     1320

aaaccctata caagttgttc tagtaacaat acatgagaaa gatgtctatg tagctgaaaa     1380

taaaatgacg tcacaagaca a                                               1401


<210> 3
<211> 346
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210> 4
<211> 1401
<212> DNA
<213> Homo sapiens

<400> 4
agtgtgaaat cttcagagaa gaatttctct ttagttcttt gcaagaaggt agagataaag       60

acactttttc aaaaatggca atggtatcag aattcctcaa gcaggcctgg tttattgaaa      120

atgaagagca ggaatatgtt caaactgtga agtcatccaa aggtggtccc ggatcagcgg      180

tgagccccta tcctaccttc aatccatcct cggatgtcgc tgccttgcat aaggccataa      240

tggttaaagg tgtggatgaa gcaaccatca ttgacattct aactaagcga aacaatgcac      300

agcgtcaaca gatcaaagca gcatatctcc aggaaacagg aaagcccctg gatgaaacac      360

tgaagaaagc ccttacaggt caccttgagg aggttgtttt agctctgcta aaaactccag      420

cgcaatttga tgctgatgaa cttcgtgctg ccatgaaggg ccttggaact gatgaagata      480

ctctaattga gattttggca tcaagaacta acaaagaaat cagagacatt aacagggtct      540

acagagagga actgaagaga gatctggcca aagacataac ctcagacaca tctggagatt      600

ttcggaacgc tttgctttct cttgctaagg gtgaccgatc tgaggacttt ggtgtgaatg      660

aagacttggc tgattcagat gccagggcct tgtatgaagc aggagaaagg agaaagggga      720

cagacgtaaa cgtgttcaat accatcctta ccaccagaag ctatccacaa cttcgcagag      780

tgtttcagaa atacaccaag tacagtaagc atgacatgaa caaagttctg gacctggagt      840

tgaaaggtga cattgagaaa tgcctcacag ctatcgtgaa gtgcgccaca agcaaaccag      900

ctttctttgc agagaagctt catcaagcca tgaaaggtgt tggaactcgc cataaggcat      960

tgatcaggat tatggtttcc cgttctgaaa ttgacatgaa tgatatcaaa gcattctatc     1020

agaagatgta tggtatctcc ctttgccaag ccatcctgga tgaaaccaaa ggagattatg     1080

agaaaatcct ggtggctctt tgtggaggaa actaaacatt cccttgatgg tctcaagcta     1140

tgatcagaag actttaatta tatattttca tcctataagc ttaaatagga aagtttcttc     1200

aacaggatta cagtgtagct acctacatgc tgaaaaatat agcctttaaa tcatttttat     1260

attataactc tgtataatag agataagtcc attttttaaa aatgttttcc ccaaaccata     1320

aaaccctata caagttgttc tagtaacaat acatgagaaa gatgtctatg tagctgaaaa     1380

taaaatgacg tcacaagaca a                                               1401


<210> 5
<211> 909
<212> DNA
<213> Homo sapiens

<400> 5
agagaccccg gagccccagc cccaccatga ccctcggccg ccgactcgcg tgtcttttcc       60

tcgcctgtgt cctgccggcc ttgctgctgg ggggcaccgc gctggcctcg gagattgtgg      120

ggggccggcg agcgcggccc cacgcgtggc ccttcatggt gtccctgcag ctgcgcggag      180

gccacttctg cggcgccacc ctgattgcgc ccaacttcgt catgtcggcc gcgcactgcg      240

tggcgaatgt aaacgtccgc gcggtgcggg tggtcctggg agcccataac ctctcgcggc      300

gggagcccac ccggcaggtg ttcgccgtgc agcgcatctt cgaaaacggc tacgaccccg      360

taaacttgct caacgacatc gtgattctcc agctcaacgg gtcggccacc atcaacgcca      420

acgtgcaggt ggcccagctg ccggctcagg gacgccgcct gggcaacggg gtgcagtgcc      480

tggccatggg ctggggcctt ctgggcagga accgtgggat cgccagcgtc ctgcaggagc      540

tcaacgtgac ggtggtgacg tccctctgcc gtcgcagcaa cgtctgcact ctcgtgaggg      600

gccggcaggc cggcgtctgt ttcggggact ccggcagccc cttggtctgc aacgggctaa      660

tccacggaat tgcctccttc gtccggggag gctgcgcctc agggctctac cccgatgcct      720

ttgccccggt ggcacagttt gtaaactgga tcgactctat catccaacgc tccgaggaca      780

acccctgtcc ccacccccgg gacccggacc cggccagcag gacccactga gaagggctgc      840

ccgggtcacc tcagctgccc acacccacac tctccagcat ctggcacaat aaacattctc      900

tgttttgta                                                              909


<210> 6
<211> 267
<212> PRT
<213> Homo sapiens

<400> 6
Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu 
1               5                   10                  15      


Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala Ser Glu Ile Val Gly 
            20                  25                  30          


Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val Ser Leu Gln 
        35                  40                  45              


Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Pro Asn Phe 
    50                  55                  60                  


Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val Arg Ala Val 
65                  70                  75                  80  


Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu Pro Thr Arg 
                85                  90                  95      


Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr Asp Pro Val 
            100                 105                 110         


Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly Ser Ala Thr 
        115                 120                 125             


Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln Gly Arg Arg 
    130                 135                 140                 


Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly Leu Leu Gly 
145                 150                 155                 160 


Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn Val Thr Val 
                165                 170                 175     


Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu Val Arg Gly 
            180                 185                 190         


Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro Leu Val Cys 
        195                 200                 205             


Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly Gly Cys Ala 
    210                 215                 220                 


Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln Phe Val Asn 
225                 230                 235                 240 


Trp Ile Asp Ser Ile Ile Gln Arg Ser Glu Asp Asn Pro Cys Pro His 
                245                 250                 255     


Pro Arg Asp Pro Asp Pro Ala Ser Arg Thr His 
            260                 265         


<210> 7
<211> 987
<212> DNA
<213> Homo sapiens

<400> 7
ggaccccacc atggctcacc ggccccccag ccctgccctg gcgtccgtgc tgctggcctt       60

gctgctgagc ggtgctgccc gagctgcgga gatcgtgggc gggcacgagg cgcagccaca      120

ctcccggccc tacatggcct ccctgcagat gcgggggaac ccgggcagcc acttctgcgg      180

aggcaccttg atccacccca gcttcgtgct gacggccgcg cactgcctgc gggacatacc      240

ccagcgcctg gtgaacgtgg tgctcggagc ccacaacgtg cggacgcagg agcccaccca      300

gcagcacttc tcggtggctc aggtgtttct gaacaactac gacgcggaga acaaactgaa      360

cgacgttctc ctcatccagc tgagcagccc agccaacctc agtgcctccg tcgccacagt      420

ccagctgcca cagcaggacc agccagtgcc ccacggcacc cagtgcctgg ccatgggctg      480

gggccgcgtg ggtgcccacg accccccagc ccaggtcctg caggagctca atgtcaccgt      540

ggtcaccttc ttctgccggc cacataacat ttgcactttc gtccctcgcc gcaaggccgg      600

catctgcttc ggagactcag gtggccccct gatctgtgat ggcatcatcc aaggaataga      660

ctccttcgtg atctggggat gtgccacccg ccttttccct gacttcttca cgcgggtagc      720

cctctacgtg gactggatcc gttccacgct gcgccgtgtg gaggccaagg gccgcccctg      780

aaccgcccct cccacagcgc tggccgggac cccgagcctg gctccaaacc ctcgaggcgg      840

atctttggac agaagcagct cttccccgaa cactgtggcg tccgggacgg ccccacccgt      900

ccccccacac tccctcccac ggggctccgg gagacaggcc ggccctgcac ctcaccccac      960

cgtgacctca ataaacgttg aaactcc                                          987


<210> 8
<211> 256
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala His Arg Pro Pro Ser Pro Ala Leu Ala Ser Val Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ser Gly Ala Ala Arg Ala Ala Glu Ile Val Gly Gly His 
            20                  25                  30          


Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Met Arg 
        35                  40                  45              


Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr Leu Ile His Pro Ser 
    50                  55                  60                  


Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp Ile Pro Gln Arg Leu 
65                  70                  75                  80  


Val Asn Val Val Leu Gly Ala His Asn Val Arg Thr Gln Glu Pro Thr 
                85                  90                  95      


Gln Gln His Phe Ser Val Ala Gln Val Phe Leu Asn Asn Tyr Asp Ala 
            100                 105                 110         


Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln Leu Ser Ser Pro Ala 
        115                 120                 125             


Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu Pro Gln Gln Asp Gln 
    130                 135                 140                 


Pro Val Pro His Gly Thr Gln Cys Leu Ala Met Gly Trp Gly Arg Val 
145                 150                 155                 160 


Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln Glu Leu Asn Val Thr 
                165                 170                 175     


Val Val Thr Phe Phe Cys Arg Pro His Asn Ile Cys Thr Phe Val Pro 
            180                 185                 190         


Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser Gly Gly Pro Leu Ile 
        195                 200                 205             


Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe Val Ile Trp Gly Cys 
    210                 215                 220                 


Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg Val Ala Leu Tyr Val 
225                 230                 235                 240 


Asp Trp Ile Arg Ser Thr Leu Arg Arg Val Glu Ala Lys Gly Arg Pro 
                245                 250                 255     


<210> 9
<211> 725
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr 
                85                  90                  95      


Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu 
            100                 105                 110         


Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu 
        115                 120                 125             


Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu 
    130                 135                 140                 


Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys 
145                 150                 155                 160 


Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn 
                165                 170                 175     


Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala 
            180                 185                 190         


Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg 
        195                 200                 205             


Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr 
    210                 215                 220                 


Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly 
225                 230                 235                 240 


Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys 
                245                 250                 255     


Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys 
            260                 265                 270         


Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr 
        275                 280                 285             


Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu 
    290                 295                 300                 


Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn 
305                 310                 315                 320 


Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu 
                325                 330                 335     


Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala 
            340                 345                 350         


Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr 
        355                 360                 365             


Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu 
    370                 375                 380                 


Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr 
385                 390                 395                 400 


Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu 
                405                 410                 415     


Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val 
            420                 425                 430         


Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn 
        435                 440                 445             


Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile 
    450                 455                 460                 


Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn 
465                 470                 475                 480 


Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr 
                485                 490                 495     


Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile 
            500                 505                 510         


Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val 
        515                 520                 525             


Ser Arg Asp Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser 
    530                 535                 540                 


Gln Glu Pro Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Val Ala 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Val Gly Asp Gly Val Gln Glu Pro Thr Thr Gly 
                565                 570                 575     


Asn Trp Arg Gly Met Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu Ala 
            580                 585                 590         


Glu Glu Lys Ser Lys Pro Ile Pro Ile Met Pro Ala Ser Pro Gln Lys 
        595                 600                 605             


Gly His Ala Val Asn Leu Leu Asp Val Pro Val Pro Val Ala Arg Lys 
    610                 615                 620                 


Leu Ser Ala Arg Glu Gln Arg Asp Cys Glu Val Ile Glu Arg Leu Ile 
625                 630                 635                 640 


Lys Ser Tyr Phe Leu Ile Val Arg Lys Asn Ile Gln Asp Ser Val Pro 
                645                 650                 655     


Lys Ala Val Met His Phe Leu Val Asn His Val Lys Asp Thr Leu Gln 
            660                 665                 670         


Ser Glu Leu Val Gly Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp Leu 
        675                 680                 685             


Leu Thr Glu Ser Glu Asp Met Ala Gln Arg Arg Lys Glu Ala Ala Asp 
    690                 695                 700                 


Met Leu Lys Ala Leu Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile Arg 
705                 710                 715                 720 


Glu Thr His Leu Trp 
                725 


<210> 10
<211> 749
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Asp Pro Ala Thr Trp Lys Asn Ser Arg His Leu Ser Lys 
                85                  90                  95      


Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr Lys Asn Lys 
            100                 105                 110         


Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu Asn Glu Thr 
        115                 120                 125             


Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu Pro Ile His 
    130                 135                 140                 


Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu Val Asp Leu 
145                 150                 155                 160 


Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys Asp Ile Glu 
                165                 170                 175     


Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn Pro Asn Ser 
            180                 185                 190         


Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala Thr Ser Glu 
        195                 200                 205             


Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg Arg Thr Leu 
    210                 215                 220                 


Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr Asp Ala Met 
225                 230                 235                 240 


Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly Ile Ile Gly 
                245                 250                 255     


Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys Ser Val Thr 
            260                 265                 270         


Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys Tyr Pro Ser 
        275                 280                 285             


Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr Leu Asn Arg 
    290                 295                 300                 


Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu Lys Thr Arg 
305                 310                 315                 320 


Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn Ser Tyr Gly 
                325                 330                 335     


Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu Ile Thr Lys 
            340                 345                 350         


Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala Lys Tyr Ile 
        355                 360                 365             


Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr Ile Phe His 
    370                 375                 380                 


Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu Gly Gly Leu 
385                 390                 395                 400 


Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr Gly Pro Arg 
                405                 410                 415     


Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu Val Lys Arg 
            420                 425                 430         


Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val Glu Leu Val 
        435                 440                 445             


His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn Tyr Ser Thr 
    450                 455                 460                 


Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile Val Glu Val 
465                 470                 475                 480 


Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn Glu Met Val 
                485                 490                 495     


His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr Lys His Pro 
            500                 505                 510         


Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile Glu Glu Gln 
        515                 520                 525             


Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val Ser Arg Asp 
    530                 535                 540                 


Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser Gln Glu Pro 
545                 550                 555                 560 


Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Leu Ile Gln Asp Ser 
                565                 570                 575     


Arg Arg Glu Thr Lys Asn Val Ala Ser Gly Gly Gly Gly Val Gly Asp 
            580                 585                 590         


Gly Val Gln Glu Pro Thr Thr Gly Asn Trp Arg Gly Met Leu Lys Thr 
        595                 600                 605             


Ser Lys Ala Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys Pro Ile Pro 
    610                 615                 620                 


Ile Met Pro Ala Ser Pro Gln Lys Gly His Ala Val Asn Leu Leu Asp 
625                 630                 635                 640 


Val Pro Val Pro Val Ala Arg Lys Leu Ser Ala Arg Glu Gln Arg Asp 
                645                 650                 655     


Cys Glu Val Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu Ile Val Arg 
            660                 665                 670         


Lys Asn Ile Gln Asp Ser Val Pro Lys Ala Val Met His Phe Leu Val 
        675                 680                 685             


Asn His Val Lys Asp Thr Leu Gln Ser Glu Leu Val Gly Gln Leu Tyr 
    690                 695                 700                 


Lys Ser Ser Leu Leu Asp Asp Leu Leu Thr Glu Ser Glu Asp Met Ala 
705                 710                 715                 720 


Gln Arg Arg Lys Glu Ala Ala Asp Met Leu Lys Ala Leu Gln Gly Ala 
                725                 730                 735     


Ser Gln Ile Ile Ala Glu Ile Arg Glu Thr His Leu Trp 
            740                 745                 


<210> 11
<211> 738
<212> PRT
<213> Homo sapiens

<400> 11
Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Asp Pro Ala Thr Trp Lys Asn Ser Arg His Leu Ser Lys 
                85                  90                  95      


Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr Lys Asn Lys 
            100                 105                 110         


Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu Asn Glu Thr 
        115                 120                 125             


Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu Pro Ile His 
    130                 135                 140                 


Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu Val Asp Leu 
145                 150                 155                 160 


Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys Asp Ile Glu 
                165                 170                 175     


Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn Pro Asn Ser 
            180                 185                 190         


Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala Thr Ser Glu 
        195                 200                 205             


Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg Arg Thr Leu 
    210                 215                 220                 


Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr Asp Ala Met 
225                 230                 235                 240 


Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly Ile Ile Gly 
                245                 250                 255     


Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys Ser Val Thr 
            260                 265                 270         


Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys Tyr Pro Ser 
        275                 280                 285             


Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr Leu Asn Arg 
    290                 295                 300                 


Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu Lys Thr Arg 
305                 310                 315                 320 


Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn Ser Tyr Gly 
                325                 330                 335     


Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu Ile Thr Lys 
            340                 345                 350         


Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala Lys Tyr Ile 
        355                 360                 365             


Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr Ile Phe His 
    370                 375                 380                 


Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu Gly Gly Leu 
385                 390                 395                 400 


Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr Gly Pro Arg 
                405                 410                 415     


Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu Val Lys Arg 
            420                 425                 430         


Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val Glu Leu Val 
        435                 440                 445             


His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn Tyr Ser Thr 
    450                 455                 460                 


Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile Val Glu Val 
465                 470                 475                 480 


Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn Glu Met Val 
                485                 490                 495     


His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr Lys His Pro 
            500                 505                 510         


Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile Glu Glu Gln 
        515                 520                 525             


Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val Ser Arg Asp 
    530                 535                 540                 


Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser Gln Glu Pro 
545                 550                 555                 560 


Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Val Ala Ser Gly Gly 
                565                 570                 575     


Gly Gly Val Gly Asp Gly Val Gln Glu Pro Thr Thr Gly Asn Trp Arg 
            580                 585                 590         


Gly Met Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu Ala Glu Glu Lys 
        595                 600                 605             


Ser Lys Pro Ile Pro Ile Met Pro Ala Ser Pro Gln Lys Gly His Ala 
    610                 615                 620                 


Val Asn Leu Leu Asp Val Pro Val Pro Val Ala Arg Lys Leu Ser Ala 
625                 630                 635                 640 


Arg Glu Gln Arg Asp Cys Glu Val Ile Glu Arg Leu Ile Lys Ser Tyr 
                645                 650                 655     


Phe Leu Ile Val Arg Lys Asn Ile Gln Asp Ser Val Pro Lys Ala Val 
            660                 665                 670         


Met His Phe Leu Val Asn His Val Lys Asp Thr Leu Gln Ser Glu Leu 
        675                 680                 685             


Val Gly Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp Leu Leu Thr Glu 
    690                 695                 700                 


Ser Glu Asp Met Ala Gln Arg Arg Lys Glu Ala Ala Asp Met Leu Lys 
705                 710                 715                 720 


Ala Leu Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile Arg Glu Thr His 
                725                 730                 735     


Leu Trp 
        


<210> 12
<211> 533
<212> PRT
<213> Homo sapiens

<400> 12
Met Phe His Lys Lys Ile Asn Gly Lys Gln Gln Glu Lys Lys Met Thr 
1               5                   10                  15      


Leu Leu His Gly Lys Thr Gln Asp Thr Phe Leu Lys Gly Trp Lys Gln 
            20                  25                  30          


Lys Asn Gly Val Asn Phe Phe Thr Pro Lys Ile Arg Ser Gln Leu Asp 
        35                  40                  45              


Ile Asn Asn Lys Lys Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala 
    50                  55                  60                  


Phe Leu Gln Lys Lys Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys 
65                  70                  75                  80  


Tyr Leu Ala Arg Thr Leu Asn Arg Leu Leu Met His His Ile Arg Asp 
                85                  90                  95      


Cys Leu Pro Glu Leu Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr 
            100                 105                 110         


Gln Ser Leu Leu Asn Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala 
        115                 120                 125             


Thr Leu Leu Gln Leu Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr 
    130                 135                 140                 


Ile Glu Gly Thr Ala Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly 
145                 150                 155                 160 


Ala Arg Ile Cys Tyr Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu 
                165                 170                 175     


Ser Val Asp Pro Leu Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala 
            180                 185                 190         


Ile Arg Asn Ala Thr Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val 
        195                 200                 205             


Ser Phe Glu Leu Leu Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro 
    210                 215                 220                 


Ser Leu Arg Cys Val Glu Leu Val His Glu Glu Met Gln Arg Ile Ile 
225                 230                 235                 240 


Gln His Cys Ser Asn Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys 
                245                 250                 255     


Leu His Asp Ala Ile Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg 
            260                 265                 270         


Leu Pro Val Thr Asn Glu Met Val His Asn Leu Val Ala Ile Glu Leu 
        275                 280                 285             


Ala Tyr Ile Asn Thr Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu 
    290                 295                 300                 


Met Asn Asn Asn Ile Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu 
305                 310                 315                 320 


Leu Pro Ser Ala Val Ser Arg Asp Lys Ser Ser Lys Val Pro Ser Ala 
                325                 330                 335     


Leu Ala Pro Ala Ser Gln Glu Pro Ser Pro Ala Ala Ser Ala Glu Ala 
            340                 345                 350         


Asp Gly Lys Leu Ile Gln Asp Ser Arg Arg Glu Thr Lys Asn Val Ala 
        355                 360                 365             


Ser Gly Gly Gly Gly Val Gly Asp Gly Val Gln Glu Pro Thr Thr Gly 
    370                 375                 380                 


Asn Trp Arg Gly Met Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu Ala 
385                 390                 395                 400 


Glu Glu Lys Ser Lys Pro Ile Pro Ile Met Pro Ala Ser Pro Gln Lys 
                405                 410                 415     


Gly His Ala Val Asn Leu Leu Asp Val Pro Val Pro Val Ala Arg Lys 
            420                 425                 430         


Leu Ser Ala Arg Glu Gln Arg Asp Cys Glu Val Ile Glu Arg Leu Ile 
        435                 440                 445             


Lys Ser Tyr Phe Leu Ile Val Arg Lys Asn Ile Gln Asp Ser Val Pro 
    450                 455                 460                 


Lys Ala Val Met His Phe Leu Val Asn His Val Lys Asp Thr Leu Gln 
465                 470                 475                 480 


Ser Glu Leu Val Gly Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp Leu 
                485                 490                 495     


Leu Thr Glu Ser Glu Asp Met Ala Gln Arg Arg Lys Glu Ala Ala Asp 
            500                 505                 510         


Met Leu Lys Ala Leu Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile Arg 
        515                 520                 525             


Glu Thr His Leu Trp 
    530             


<210> 13
<211> 712
<212> PRT
<213> Homo sapiens

<400> 13
Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Asp Pro Ala Thr Trp Lys Asn Ser Arg His Leu Ser Lys 
                85                  90                  95      


Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr Lys Asn Lys 
            100                 105                 110         


Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu Asn Glu Thr 
        115                 120                 125             


Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu Pro Ile His 
    130                 135                 140                 


Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu Val Asp Leu 
145                 150                 155                 160 


Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys Asp Ile Glu 
                165                 170                 175     


Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn Pro Asn Ser 
            180                 185                 190         


Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala Thr Ser Glu 
        195                 200                 205             


Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg Arg Thr Leu 
    210                 215                 220                 


Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr Asp Ala Met 
225                 230                 235                 240 


Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly Ile Ile Gly 
                245                 250                 255     


Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys Ser Val Thr 
            260                 265                 270         


Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys Tyr Pro Ser 
        275                 280                 285             


Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr Leu Asn Arg 
    290                 295                 300                 


Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu Lys Thr Arg 
305                 310                 315                 320 


Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn Ser Tyr Gly 
                325                 330                 335     


Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu Ile Thr Lys 
            340                 345                 350         


Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala Lys Tyr Ile 
        355                 360                 365             


Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr Ile Phe His 
    370                 375                 380                 


Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu Gly Gly Leu 
385                 390                 395                 400 


Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr Gly Pro Arg 
                405                 410                 415     


Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu Val Lys Arg 
            420                 425                 430         


Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val Glu Leu Val 
        435                 440                 445             


His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn Tyr Ser Thr 
    450                 455                 460                 


Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile Val Glu Val 
465                 470                 475                 480 


Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn Glu Met Val 
                485                 490                 495     


His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr Lys His Pro 
            500                 505                 510         


Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile Glu Glu Gln 
        515                 520                 525             


Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val Ser Arg Asp 
    530                 535                 540                 


Lys Val Ala Ser Gly Gly Gly Gly Val Gly Asp Gly Val Gln Glu Pro 
545                 550                 555                 560 


Thr Thr Gly Asn Trp Arg Gly Met Leu Lys Thr Ser Lys Ala Glu Glu 
                565                 570                 575     


Leu Leu Ala Glu Glu Lys Ser Lys Pro Ile Pro Ile Met Pro Ala Ser 
            580                 585                 590         


Pro Gln Lys Gly His Ala Val Asn Leu Leu Asp Val Pro Val Pro Val 
        595                 600                 605             


Ala Arg Lys Leu Ser Ala Arg Glu Gln Arg Asp Cys Glu Val Ile Glu 
    610                 615                 620                 


Arg Leu Ile Lys Ser Tyr Phe Leu Ile Val Arg Lys Asn Ile Gln Asp 
625                 630                 635                 640 


Ser Val Pro Lys Ala Val Met His Phe Leu Val Asn His Val Lys Asp 
                645                 650                 655     


Thr Leu Gln Ser Glu Leu Val Gly Gln Leu Tyr Lys Ser Ser Leu Leu 
            660                 665                 670         


Asp Asp Leu Leu Thr Glu Ser Glu Asp Met Ala Gln Arg Arg Lys Glu 
        675                 680                 685             


Ala Ala Asp Met Leu Lys Ala Leu Gln Gly Ala Ser Gln Ile Ile Ala 
    690                 695                 700                 


Glu Ile Arg Glu Thr His Leu Trp 
705                 710         


<210> 14
<211> 699
<212> PRT
<213> Homo sapiens

<400> 14
Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr 
                85                  90                  95      


Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu 
            100                 105                 110         


Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu 
        115                 120                 125             


Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu 
    130                 135                 140                 


Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys 
145                 150                 155                 160 


Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn 
                165                 170                 175     


Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala 
            180                 185                 190         


Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg 
        195                 200                 205             


Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr 
    210                 215                 220                 


Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly 
225                 230                 235                 240 


Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys 
                245                 250                 255     


Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys 
            260                 265                 270         


Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr 
        275                 280                 285             


Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu 
    290                 295                 300                 


Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn 
305                 310                 315                 320 


Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu 
                325                 330                 335     


Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala 
            340                 345                 350         


Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr 
        355                 360                 365             


Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu 
    370                 375                 380                 


Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr 
385                 390                 395                 400 


Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu 
                405                 410                 415     


Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val 
            420                 425                 430         


Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn 
        435                 440                 445             


Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile 
    450                 455                 460                 


Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn 
465                 470                 475                 480 


Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr 
                485                 490                 495     


Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile 
            500                 505                 510         


Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val 
        515                 520                 525             


Ser Arg Asp Lys Val Ala Ser Gly Gly Gly Gly Val Gly Asp Gly Val 
    530                 535                 540                 


Gln Glu Pro Thr Thr Gly Asn Trp Arg Gly Met Leu Lys Thr Ser Lys 
545                 550                 555                 560 


Ala Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys Pro Ile Pro Ile Met 
                565                 570                 575     


Pro Ala Ser Pro Gln Lys Gly His Ala Val Asn Leu Leu Asp Val Pro 
            580                 585                 590         


Val Pro Val Ala Arg Lys Leu Ser Ala Arg Glu Gln Arg Asp Cys Glu 
        595                 600                 605             


Val Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu Ile Val Arg Lys Asn 
    610                 615                 620                 


Ile Gln Asp Ser Val Pro Lys Ala Val Met His Phe Leu Val Asn His 
625                 630                 635                 640 


Val Lys Asp Thr Leu Gln Ser Glu Leu Val Gly Gln Leu Tyr Lys Ser 
                645                 650                 655     


Ser Leu Leu Asp Asp Leu Leu Thr Glu Ser Glu Asp Met Ala Gln Arg 
            660                 665                 670         


Arg Lys Glu Ala Ala Asp Met Leu Lys Ala Leu Gln Gly Ala Ser Gln 
        675                 680                 685             


Ile Ile Ala Glu Ile Arg Glu Thr His Leu Trp 
    690                 695                 


<210> 15
<211> 736
<212> PRT
<213> Homo sapiens

<400> 15
Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr 
                85                  90                  95      


Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu 
            100                 105                 110         


Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu 
        115                 120                 125             


Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu 
    130                 135                 140                 


Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys 
145                 150                 155                 160 


Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn 
                165                 170                 175     


Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala 
            180                 185                 190         


Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg 
        195                 200                 205             


Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr 
    210                 215                 220                 


Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly 
225                 230                 235                 240 


Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys 
                245                 250                 255     


Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys 
            260                 265                 270         


Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr 
        275                 280                 285             


Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu 
    290                 295                 300                 


Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn 
305                 310                 315                 320 


Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu 
                325                 330                 335     


Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala 
            340                 345                 350         


Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr 
        355                 360                 365             


Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu 
    370                 375                 380                 


Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr 
385                 390                 395                 400 


Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu 
                405                 410                 415     


Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val 
            420                 425                 430         


Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn 
        435                 440                 445             


Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile 
    450                 455                 460                 


Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn 
465                 470                 475                 480 


Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr 
                485                 490                 495     


Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile 
            500                 505                 510         


Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val 
        515                 520                 525             


Ser Arg Asp Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser 
    530                 535                 540                 


Gln Glu Pro Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Leu Ile 
545                 550                 555                 560 


Gln Asp Ser Arg Arg Glu Thr Lys Asn Val Ala Ser Gly Gly Gly Gly 
                565                 570                 575     


Val Gly Asp Gly Val Gln Glu Pro Thr Thr Gly Asn Trp Arg Gly Met 
            580                 585                 590         


Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys 
        595                 600                 605             


Pro Ile Pro Ile Met Pro Ala Ser Pro Gln Lys Gly His Ala Val Asn 
    610                 615                 620                 


Leu Leu Asp Val Pro Val Pro Val Ala Arg Lys Leu Ser Ala Arg Glu 
625                 630                 635                 640 


Gln Arg Asp Cys Glu Val Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu 
                645                 650                 655     


Ile Val Arg Lys Asn Ile Gln Asp Ser Val Pro Lys Ala Val Met His 
            660                 665                 670         


Phe Leu Val Asn His Val Lys Asp Thr Leu Gln Ser Glu Leu Val Gly 
        675                 680                 685             


Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp Leu Leu Thr Glu Ser Glu 
    690                 695                 700                 


Asp Met Ala Gln Arg Arg Lys Glu Ala Ala Asp Met Leu Lys Ala Leu 
705                 710                 715                 720 


Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile Arg Glu Thr His Leu Trp 
                725                 730                 735     


<210> 16
<211> 710
<212> PRT
<213> Homo sapiens

<400> 16
Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr 
                85                  90                  95      


Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu 
            100                 105                 110         


Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu 
        115                 120                 125             


Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu 
    130                 135                 140                 


Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys 
145                 150                 155                 160 


Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn 
                165                 170                 175     


Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala 
            180                 185                 190         


Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg 
        195                 200                 205             


Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr 
    210                 215                 220                 


Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly 
225                 230                 235                 240 


Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys 
                245                 250                 255     


Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys 
            260                 265                 270         


Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr 
        275                 280                 285             


Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu 
    290                 295                 300                 


Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn 
305                 310                 315                 320 


Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu 
                325                 330                 335     


Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala 
            340                 345                 350         


Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr 
        355                 360                 365             


Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu 
    370                 375                 380                 


Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr 
385                 390                 395                 400 


Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu 
                405                 410                 415     


Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val 
            420                 425                 430         


Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn 
        435                 440                 445             


Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile 
    450                 455                 460                 


Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn 
465                 470                 475                 480 


Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr 
                485                 490                 495     


Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile 
            500                 505                 510         


Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val 
        515                 520                 525             


Ser Arg Asp Lys Leu Ile Gln Asp Ser Arg Arg Glu Thr Lys Asn Val 
    530                 535                 540                 


Ala Ser Gly Gly Gly Gly Val Gly Asp Gly Val Gln Glu Pro Thr Thr 
545                 550                 555                 560 


Gly Asn Trp Arg Gly Met Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu 
                565                 570                 575     


Ala Glu Glu Lys Ser Lys Pro Ile Pro Ile Met Pro Ala Ser Pro Gln 
            580                 585                 590         


Lys Gly His Ala Val Asn Leu Leu Asp Val Pro Val Pro Val Ala Arg 
        595                 600                 605             


Lys Leu Ser Ala Arg Glu Gln Arg Asp Cys Glu Val Ile Glu Arg Leu 
    610                 615                 620                 


Ile Lys Ser Tyr Phe Leu Ile Val Arg Lys Asn Ile Gln Asp Ser Val 
625                 630                 635                 640 


Pro Lys Ala Val Met His Phe Leu Val Asn His Val Lys Asp Thr Leu 
                645                 650                 655     


Gln Ser Glu Leu Val Gly Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp 
            660                 665                 670         


Leu Leu Thr Glu Ser Glu Asp Met Ala Gln Arg Arg Lys Glu Ala Ala 
        675                 680                 685             


Asp Met Leu Lys Ala Leu Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile 
    690                 695                 700                 


Arg Glu Thr His Leu Trp 
705                 710 


<210> 17
<211> 4582
<212> DNA
<213> Homo sapiens

<400> 17
agcgcatggc ctgccgggag ggggcaggta gccggcgggc ccggtccaat gggtgccggc       60

ttccgaggag agggcggagg agaggaggaa ggaggcgaac tgtgggcccc ggccccattc      120

attgccgtgg ccggcgggca ctggggcccc gtgttttcag agtcatggag gcgctaattc      180

ctgtcataaa caagctccag gacgtcttca acacggtggg cgccgacatc atccagctgc      240

ctcaaatcgt cgtagtggga acgcagagca gcggaaagag ctcagtgcta gaaagcctgg      300

tggggaggga cctgcttccc agaggtactg gaattgtcac ccggagacct ctcattctgc      360

aactggtcca tgtttcacaa gaagataaac ggaaaacaac aggagaagaa aatggggtgg      420

aagcagaaga atggggtaaa tttcttcaca ccaaaaataa gctttacacg gattttgatg      480

aaattcgaca agaaattgaa aatgaaacag aaagaatttc aggaaataat aagggagtaa      540

gccctgaacc aattcatctt aagatttttt cacccaacgt tgtcaatttg acacttgtgg      600

atttgccagg aatgaccaag gtgcctgtag gtgatcaacc taaggatatt gagcttcaaa      660

tcagagagct cattcttcgg ttcatcagta atcctaattc cattatcctc gctgtcactg      720

ctgctaatac agatatggca acatcagagg cacttaaaat ttcaagagag gtagatccag      780

atggtcgcag aaccctagct gtaatcacta aacttgatct catggatgcg ggtactgatg      840

ccatggatgt attgatggga agggttattc cagtcaaact tggaataatt ggagtagtta      900

acaggagcca gctagatatt aacaacaaga agagtgtaac tgattcaatc cgtgatgagt      960

atgcttttct tcaaaagaaa tatccatctc tggccaatag aaatggaaca aagtatcttg     1020

ctaggactct aaacaggtta ctgatgcatc acatcagaga ttgtttacca gagttgaaaa     1080

caagaataaa tgttctagct gctcagtatc agtctcttct aaatagctac ggtgaacccg     1140

tggatgataa aagtgctact ttactccaac ttattaccaa atttgccaca gaatattgta     1200

acactattga aggaactgca aaatatattg aaacttcgga gctatgcggt ggtgctagaa     1260

tttgttatat tttccatgag acttttgggc gaaccttaga atctgttgat ccacttggtg     1320

gccttaacac tattgacatt ttgactgcca ttagaaatgc tactggtcct cgtcctgctt     1380

tatttgtgcc tgaggtttca tttgagttac tggtgaagcg gcaaatcaaa cgtctagaag     1440

agcccagcct ccgctgtgtg gaactggttc atgaggaaat gcaaaggatc attcagcact     1500

gtagcaatta cagtacacag gaattgttac gatttcctaa acttcatgat gccatagttg     1560

aagtggtgac ttgtcttctt cgtaaaaggt tgcctgttac aaatgaaatg gtccataact     1620

tagtggcaat tgaactggct tatatcaaca caaaacatcc agactttgct gatgcttgtg     1680

ggctaatgaa caataatata gaggaacaaa ggagaaacag gctagccaga gaattacctt     1740

cagctgtatc acgagacaag tcttctaaag ttccaagtgc tttggcacct gcctcccagg     1800

agccctcccc cgctgcttct gctgaggctg atggcaaggt tgcatctgga ggtggtgggg     1860

ttggagatgg tgttcaagaa ccaaccacag gcaactggag aggaatgctg aaaacttcaa     1920

aagctgaaga gttattagca gaagaaaaat caaaacccat tccaattatg ccagccagtc     1980

cacaaaaagg tcatgccgtg aacctgctag atgtgccagt tcctgttgca cgaaaactat     2040

ctgctcggga acagcgagat tgtgaggtta ttgaacgact cattaaatca tattttctca     2100

ttgtcagaaa gaatattcaa gacagtgtgc caaaggcagt aatgcatttt ttggttaatc     2160

atgtgaaaga cactcttcag agtgagctag taggccagct gtataaatca tccttattgg     2220

atgatcttct gacagaatct gaggacatgg cacagcgcag gaaagaagca gctgatatgc     2280

taaaggcatt acaaggagcc agtcaaatta ttgctgaaat ccgggagact catctttggt     2340

gaagagaact atgtaatact gagactttgt tgactcaaaa cttgctagtt actgcctacc     2400

tgagtagaat cttatttatg aactcctgtg tattgcaatg gtatgaatct gctcatgtgg     2460

agactggcta taaactgaaa agtgtattcc aaattgcaga acacatcaca catttaatcc     2520

aaataataaa tggctgtttc taaagtttcc cagtatatat aaaatacatc aagtctgtct     2580

tgtgacagtt tcatctgaac ttaacttaaa aacaactgtt aatgttctag ttgtgcaaag     2640

cagtttgcct gtggataaga tgacctgtgt aataatcttt gttagtagtc ttaaagctgc     2700

tgccatagtc ctccaagaag aaagcaccaa gacaacattt catatgacta taatgcatgt     2760

actatataag ctgatctggc tttgaaagat gtgagttggc aagttcctca catagagtca     2820

ttgtattcca cctgtccttc aatttagttt tttctgagct tctttgcagc ctttgatgtg     2880

tttttaagaa agctgaatgc acaagaggat ctgtgacact gacatggctg tggtgtgcat     2940

actgtgtagt tacatagccc ttccaattct gggtccattt gcactagcaa attaaaatat     3000

gctttgattc atacttaaac ctgaaagcag gaatgcctac attaattcct acattaaaaa     3060

cagccatcta cccttgatta tctagaaaga cttggtaatg atggtcagtt ccttttagat     3120

ttcagaaaat caaatgatga cctaaatttc ccttaatttg caaatacagt agtaattaag     3180

gtacatctct aaagtggagc acttacacca ggctctaaga ttcactttga ggtggaactt     3240

aaaaccagtg tactgtatgt atgcattggt aatagctact tttgcttcat agcttcatac     3300

caacaaaata tatttattag aatagtatga aagtactgga ggagctgaaa gaaaaacacc     3360

caaggctggg cgtggtggca cacgcctgta atcccagcac tttgggaggc cgaggcaggt     3420

ggatcacctg aggttgggag ttggagacca gcttgaccaa catggagaaa ccccgtctct     3480

actaaaaata caaaattggc cgggcgtggt ggcgcatgcc tgtaatccca gctactcggg     3540

agggtgaggc aggagaattg cttgaccctg ggaggtggag gttgtggtga gctaagatcg     3600

tgccattgca ctccagcctt ggcaacaaga gcgaaactcc gtctcaaaaa aaaaaaataa     3660

aacaacaccc agatagatac acatactcct tcagacttac agacctaagc tgcatttatg     3720

gggtagtgat gaggtttaga acatatacat attttgttaa aattccccag atgattcttg     3780

gtatgaacga ctatattata aattttaaga tgtacttaga aatccttaag acatctagcc     3840

ccgtctctaa tagacaacac atttatattg cagatattac ttttttttca gtttatgacc     3900

aggtatttat gaaggactat tggcagggaa aatatgaata tgttaacttt agcttatggc     3960

atcaatttac taaggaacaa caggctcacc aactgatgtc aaacataaaa acccccacat     4020

cagtctgata cgatatggta ctactttgaa tctgttacta gtaccatctt gacagaggat     4080

acatgctccc aaaacgtttg ttaccacact taaaaatcac tgccatcatt aagcatcagt     4140

ttcaaaatta tagccattca tgatttactt tttccagatg actatcatta ttctagtcct     4200

ttgaatttgt aaggggaaaa aaaacaaaaa caaaaactta cgatgcactt ttctccagca     4260

catcagattt caaattgaaa attaaagaca tgctatggta atgcacttgc tagtactaca     4320

cactttgtac aacaaaaaac agaggcaaga aacaacggaa agagaaaagc cttcctttgt     4380

tggcccttaa actgagtcaa gatctgaaat gtagagatga tctctgacga tacctgtatg     4440

ttcttattgt gtaaataaaa ttgctggtat gaaatgacac taaagtttgt caaaaaatga     4500

attcttaact tttctcccag agaaagggag acaaaaggag ctttttaata cctaatctac     4560

tttggaacat aaccgtatag ag                                              4582


<210> 18
<211> 4654
<212> DNA
<213> Homo sapiens

<400> 18
agcgcatggc ctgccgggag ggggcaggta gccggcgggc ccggtccaat gggtgccggc       60

ttccgaggag agggcggagg agaggaggaa ggaggcgaac tgtgggcccc ggccccattc      120

attgccgtgg ccggcgggca ctggggcccc gtgttttcag agtcatggag gcgctaattc      180

ctgtcataaa caagctccag gacgtcttca acacggtggg cgccgacatc atccagctgc      240

ctcaaatcgt cgtagtggga acgcagagca gcggaaagag ctcagtgcta gaaagcctgg      300

tggggaggga cctgcttccc agaggtactg gaattgtcac ccggagacct ctcattctgc      360

aactggtcca tgtttcacaa gaagataaac ggaaaacaac aggagaagaa aatgaccctg      420

ctacatggaa aaactcaaga cacctttcta aaggggtgga agcagaagaa tggggtaaat      480

ttcttcacac caaaaataag ctttacacgg attttgatga aattcgacaa gaaattgaaa      540

atgaaacaga aagaatttca ggaaataata agggagtaag ccctgaacca attcatctta      600

agattttttc acccaacgtt gtcaatttga cacttgtgga tttgccagga atgaccaagg      660

tgcctgtagg tgatcaacct aaggatattg agcttcaaat cagagagctc attcttcggt      720

tcatcagtaa tcctaattcc attatcctcg ctgtcactgc tgctaataca gatatggcaa      780

catcagaggc acttaaaatt tcaagagagg tagatccaga tggtcgcaga accctagctg      840

taatcactaa acttgatctc atggatgcgg gtactgatgc catggatgta ttgatgggaa      900

gggttattcc agtcaaactt ggaataattg gagtagttaa caggagccag ctagatatta      960

acaacaagaa gagtgtaact gattcaatcc gtgatgagta tgcttttctt caaaagaaat     1020

atccatctct ggccaataga aatggaacaa agtatcttgc taggactcta aacaggttac     1080

tgatgcatca catcagagat tgtttaccag agttgaaaac aagaataaat gttctagctg     1140

ctcagtatca gtctcttcta aatagctacg gtgaacccgt ggatgataaa agtgctactt     1200

tactccaact tattaccaaa tttgccacag aatattgtaa cactattgaa ggaactgcaa     1260

aatatattga aacttcggag ctatgcggtg gtgctagaat ttgttatatt ttccatgaga     1320

cttttgggcg aaccttagaa tctgttgatc cacttggtgg ccttaacact attgacattt     1380

tgactgccat tagaaatgct actggtcctc gtcctgcttt atttgtgcct gaggtttcat     1440

ttgagttact ggtgaagcgg caaatcaaac gtctagaaga gcccagcctc cgctgtgtgg     1500

aactggttca tgaggaaatg caaaggatca ttcagcactg tagcaattac agtacacagg     1560

aattgttacg atttcctaaa cttcatgatg ccatagttga agtggtgact tgtcttcttc     1620

gtaaaaggtt gcctgttaca aatgaaatgg tccataactt agtggcaatt gaactggctt     1680

atatcaacac aaaacatcca gactttgctg atgcttgtgg gctaatgaac aataatatag     1740

aggaacaaag gagaaacagg ctagccagag aattaccttc agctgtatca cgagacaagt     1800

cttctaaagt tccaagtgct ttggcacctg cctcccagga gccctccccc gctgcttctg     1860

ctgaggctga tggcaagtta attcaggaca gcagaagaga aactaaaaat gttgcatctg     1920

gaggtggtgg ggttggagat ggtgttcaag aaccaaccac aggcaactgg agaggaatgc     1980

tgaaaacttc aaaagctgaa gagttattag cagaagaaaa atcaaaaccc attccaatta     2040

tgccagccag tccacaaaaa ggtcatgccg tgaacctgct agatgtgcca gttcctgttg     2100

cacgaaaact atctgctcgg gaacagcgag attgtgaggt tattgaacga ctcattaaat     2160

catattttct cattgtcaga aagaatattc aagacagtgt gccaaaggca gtaatgcatt     2220

ttttggttaa tcatgtgaaa gacactcttc agagtgagct agtaggccag ctgtataaat     2280

catccttatt ggatgatctt ctgacagaat ctgaggacat ggcacagcgc aggaaagaag     2340

cagctgatat gctaaaggca ttacaaggag ccagtcaaat tattgctgaa atccgggaga     2400

ctcatctttg gtgaagagaa ctatgtaata ctgagacttt gttgactcaa aacttgctag     2460

ttactgccta cctgagtaga atcttattta tgaactcctg tgtattgcaa tggtatgaat     2520

ctgctcatgt ggagactggc tataaactga aaagtgtatt ccaaattgca gaacacatca     2580

cacatttaat ccaaataata aatggctgtt tctaaagttt cccagtatat ataaaataca     2640

tcaagtctgt cttgtgacag tttcatctga acttaactta aaaacaactg ttaatgttct     2700

agttgtgcaa agcagtttgc ctgtggataa gatgacctgt gtaataatct ttgttagtag     2760

tcttaaagct gctgccatag tcctccaaga agaaagcacc aagacaacat ttcatatgac     2820

tataatgcat gtactatata agctgatctg gctttgaaag atgtgagttg gcaagttcct     2880

cacatagagt cattgtattc cacctgtcct tcaatttagt tttttctgag cttctttgca     2940

gcctttgatg tgtttttaag aaagctgaat gcacaagagg atctgtgaca ctgacatggc     3000

tgtggtgtgc atactgtgta gttacatagc ccttccaatt ctgggtccat ttgcactagc     3060

aaattaaaat atgctttgat tcatacttaa acctgaaagc aggaatgcct acattaattc     3120

ctacattaaa aacagccatc tacccttgat tatctagaaa gacttggtaa tgatggtcag     3180

ttccttttag atttcagaaa atcaaatgat gacctaaatt tcccttaatt tgcaaataca     3240

gtagtaatta aggtacatct ctaaagtgga gcacttacac caggctctaa gattcacttt     3300

gaggtggaac ttaaaaccag tgtactgtat gtatgcattg gtaatagcta cttttgcttc     3360

atagcttcat accaacaaaa tatatttatt agaatagtat gaaagtactg gaggagctga     3420

aagaaaaaca cccaaggctg ggcgtggtgg cacacgcctg taatcccagc actttgggag     3480

gccgaggcag gtggatcacc tgaggttggg agttggagac cagcttgacc aacatggaga     3540

aaccccgtct ctactaaaaa tacaaaattg gccgggcgtg gtggcgcatg cctgtaatcc     3600

cagctactcg ggagggtgag gcaggagaat tgcttgaccc tgggaggtgg aggttgtggt     3660

gagctaagat cgtgccattg cactccagcc ttggcaacaa gagcgaaact ccgtctcaaa     3720

aaaaaaaaat aaaacaacac ccagatagat acacatactc cttcagactt acagacctaa     3780

gctgcattta tggggtagtg atgaggttta gaacatatac atattttgtt aaaattcccc     3840

agatgattct tggtatgaac gactatatta taaattttaa gatgtactta gaaatcctta     3900

agacatctag ccccgtctct aatagacaac acatttatat tgcagatatt actttttttt     3960

cagtttatga ccaggtattt atgaaggact attggcaggg aaaatatgaa tatgttaact     4020

ttagcttatg gcatcaattt actaaggaac aacaggctca ccaactgatg tcaaacataa     4080

aaacccccac atcagtctga tacgatatgg tactactttg aatctgttac tagtaccatc     4140

ttgacagagg atacatgctc ccaaaacgtt tgttaccaca cttaaaaatc actgccatca     4200

ttaagcatca gtttcaaaat tatagccatt catgatttac tttttccaga tgactatcat     4260

tattctagtc ctttgaattt gtaaggggaa aaaaaacaaa aacaaaaact tacgatgcac     4320

ttttctccag cacatcagat ttcaaattga aaattaaaga catgctatgg taatgcactt     4380

gctagtacta cacactttgt acaacaaaaa acagaggcaa gaaacaacgg aaagagaaaa     4440

gccttccttt gttggccctt aaactgagtc aagatctgaa atgtagagat gatctctgac     4500

gatacctgta tgttcttatt gtgtaaataa aattgctggt atgaaatgac actaaagttt     4560

gtcaaaaaat gaattcttaa cttttctccc agagaaaggg agacaaaagg agctttttaa     4620

tacctaatct actttggaac ataaccgtat agag                                 4654


<210> 19
<211> 4621
<212> DNA
<213> Homo sapiens

<400> 19
agcgcatggc ctgccgggag ggggcaggta gccggcgggc ccggtccaat gggtgccggc       60

ttccgaggag agggcggagg agaggaggaa ggaggcgaac tgtgggcccc ggccccattc      120

attgccgtgg ccggcgggca ctggggcccc gtgttttcag agtcatggag gcgctaattc      180

ctgtcataaa caagctccag gacgtcttca acacggtggg cgccgacatc atccagctgc      240

ctcaaatcgt cgtagtggga acgcagagca gcggaaagag ctcagtgcta gaaagcctgg      300

tggggaggga cctgcttccc agaggtactg gaattgtcac ccggagacct ctcattctgc      360

aactggtcca tgtttcacaa gaagataaac ggaaaacaac aggagaagaa aatgaccctg      420

ctacatggaa aaactcaaga cacctttcta aaggggtgga agcagaagaa tggggtaaat      480

ttcttcacac caaaaataag ctttacacgg attttgatga aattcgacaa gaaattgaaa      540

atgaaacaga aagaatttca ggaaataata agggagtaag ccctgaacca attcatctta      600

agattttttc acccaacgtt gtcaatttga cacttgtgga tttgccagga atgaccaagg      660

tgcctgtagg tgatcaacct aaggatattg agcttcaaat cagagagctc attcttcggt      720

tcatcagtaa tcctaattcc attatcctcg ctgtcactgc tgctaataca gatatggcaa      780

catcagaggc acttaaaatt tcaagagagg tagatccaga tggtcgcaga accctagctg      840

taatcactaa acttgatctc atggatgcgg gtactgatgc catggatgta ttgatgggaa      900

gggttattcc agtcaaactt ggaataattg gagtagttaa caggagccag ctagatatta      960

acaacaagaa gagtgtaact gattcaatcc gtgatgagta tgcttttctt caaaagaaat     1020

atccatctct ggccaataga aatggaacaa agtatcttgc taggactcta aacaggttac     1080

tgatgcatca catcagagat tgtttaccag agttgaaaac aagaataaat gttctagctg     1140

ctcagtatca gtctcttcta aatagctacg gtgaacccgt ggatgataaa agtgctactt     1200

tactccaact tattaccaaa tttgccacag aatattgtaa cactattgaa ggaactgcaa     1260

aatatattga aacttcggag ctatgcggtg gtgctagaat ttgttatatt ttccatgaga     1320

cttttgggcg aaccttagaa tctgttgatc cacttggtgg ccttaacact attgacattt     1380

tgactgccat tagaaatgct actggtcctc gtcctgcttt atttgtgcct gaggtttcat     1440

ttgagttact ggtgaagcgg caaatcaaac gtctagaaga gcccagcctc cgctgtgtgg     1500

aactggttca tgaggaaatg caaaggatca ttcagcactg tagcaattac agtacacagg     1560

aattgttacg atttcctaaa cttcatgatg ccatagttga agtggtgact tgtcttcttc     1620

gtaaaaggtt gcctgttaca aatgaaatgg tccataactt agtggcaatt gaactggctt     1680

atatcaacac aaaacatcca gactttgctg atgcttgtgg gctaatgaac aataatatag     1740

aggaacaaag gagaaacagg ctagccagag aattaccttc agctgtatca cgagacaagt     1800

cttctaaagt tccaagtgct ttggcacctg cctcccagga gccctccccc gctgcttctg     1860

ctgaggctga tggcaaggtt gcatctggag gtggtggggt tggagatggt gttcaagaac     1920

caaccacagg caactggaga ggaatgctga aaacttcaaa agctgaagag ttattagcag     1980

aagaaaaatc aaaacccatt ccaattatgc cagccagtcc acaaaaaggt catgccgtga     2040

acctgctaga tgtgccagtt cctgttgcac gaaaactatc tgctcgggaa cagcgagatt     2100

gtgaggttat tgaacgactc attaaatcat attttctcat tgtcagaaag aatattcaag     2160

acagtgtgcc aaaggcagta atgcattttt tggttaatca tgtgaaagac actcttcaga     2220

gtgagctagt aggccagctg tataaatcat ccttattgga tgatcttctg acagaatctg     2280

aggacatggc acagcgcagg aaagaagcag ctgatatgct aaaggcatta caaggagcca     2340

gtcaaattat tgctgaaatc cgggagactc atctttggtg aagagaacta tgtaatactg     2400

agactttgtt gactcaaaac ttgctagtta ctgcctacct gagtagaatc ttatttatga     2460

actcctgtgt attgcaatgg tatgaatctg ctcatgtgga gactggctat aaactgaaaa     2520

gtgtattcca aattgcagaa cacatcacac atttaatcca aataataaat ggctgtttct     2580

aaagtttccc agtatatata aaatacatca agtctgtctt gtgacagttt catctgaact     2640

taacttaaaa acaactgtta atgttctagt tgtgcaaagc agtttgcctg tggataagat     2700

gacctgtgta ataatctttg ttagtagtct taaagctgct gccatagtcc tccaagaaga     2760

aagcaccaag acaacatttc atatgactat aatgcatgta ctatataagc tgatctggct     2820

ttgaaagatg tgagttggca agttcctcac atagagtcat tgtattccac ctgtccttca     2880

atttagtttt ttctgagctt ctttgcagcc tttgatgtgt ttttaagaaa gctgaatgca     2940

caagaggatc tgtgacactg acatggctgt ggtgtgcata ctgtgtagtt acatagccct     3000

tccaattctg ggtccatttg cactagcaaa ttaaaatatg ctttgattca tacttaaacc     3060

tgaaagcagg aatgcctaca ttaattccta cattaaaaac agccatctac ccttgattat     3120

ctagaaagac ttggtaatga tggtcagttc cttttagatt tcagaaaatc aaatgatgac     3180

ctaaatttcc cttaatttgc aaatacagta gtaattaagg tacatctcta aagtggagca     3240

cttacaccag gctctaagat tcactttgag gtggaactta aaaccagtgt actgtatgta     3300

tgcattggta atagctactt ttgcttcata gcttcatacc aacaaaatat atttattaga     3360

atagtatgaa agtactggag gagctgaaag aaaaacaccc aaggctgggc gtggtggcac     3420

acgcctgtaa tcccagcact ttgggaggcc gaggcaggtg gatcacctga ggttgggagt     3480

tggagaccag cttgaccaac atggagaaac cccgtctcta ctaaaaatac aaaattggcc     3540

gggcgtggtg gcgcatgcct gtaatcccag ctactcggga gggtgaggca ggagaattgc     3600

ttgaccctgg gaggtggagg ttgtggtgag ctaagatcgt gccattgcac tccagccttg     3660

gcaacaagag cgaaactccg tctcaaaaaa aaaaaataaa acaacaccca gatagataca     3720

catactcctt cagacttaca gacctaagct gcatttatgg ggtagtgatg aggtttagaa     3780

catatacata ttttgttaaa attccccaga tgattcttgg tatgaacgac tatattataa     3840

attttaagat gtacttagaa atccttaaga catctagccc cgtctctaat agacaacaca     3900

tttatattgc agatattact tttttttcag tttatgacca ggtatttatg aaggactatt     3960

ggcagggaaa atatgaatat gttaacttta gcttatggca tcaatttact aaggaacaac     4020

aggctcacca actgatgtca aacataaaaa cccccacatc agtctgatac gatatggtac     4080

tactttgaat ctgttactag taccatcttg acagaggata catgctccca aaacgtttgt     4140

taccacactt aaaaatcact gccatcatta agcatcagtt tcaaaattat agccattcat     4200

gatttacttt ttccagatga ctatcattat tctagtcctt tgaatttgta aggggaaaaa     4260

aaacaaaaac aaaaacttac gatgcacttt tctccagcac atcagatttc aaattgaaaa     4320

ttaaagacat gctatggtaa tgcacttgct agtactacac actttgtaca acaaaaaaca     4380

gaggcaagaa acaacggaaa gagaaaagcc ttcctttgtt ggcccttaaa ctgagtcaag     4440

atctgaaatg tagagatgat ctctgacgat acctgtatgt tcttattgtg taaataaaat     4500

tgctggtatg aaatgacact aaagtttgtc aaaaaatgaa ttcttaactt ttctcccaga     4560

gaaagggaga caaaaggagc tttttaatac ctaatctact ttggaacata accgtataga     4620

g                                                                     4621


<210> 20
<211> 4211
<212> DNA
<213> Homo sapiens

<400> 20
agcgcatggc ctgccgggag ggggcaggta gccggcgggc ccggtccaat gggtgccggc       60

ttccgaggag agggcggagg agaggaggaa ggaggcgaac tgtgggcccc ggccccattc      120

attgccgtgg ccggcgggca ctggggcccc gtgttttcag agtcatggag gcgctaattc      180

ctgtcataaa caagctccag gacgtcttca acacggtggg cgccgacatc atccagctgc      240

ctcaaatcgt cgtagtggga acgcagagca gcggaaagag ctcagtgcta gaaagcctgg      300

tggggaggga cctgcttccc agaggtactg gaattgtcac ccggagacct ctcattctgc      360

aactggtcca tgtttcacaa gaagataaac ggaaaacaac aggagaagaa aatgaccctg      420

ctacatggaa aaactcaaga cacctttcta aaggggtgga agcagaagaa tggggtaaat      480

ttcttcacac caaaaataag gagccagcta gatattaaca acaagaagag tgtaactgat      540

tcaatccgtg atgagtatgc ttttcttcaa aagaaatatc catctctggc caatagaaat      600

ggaacaaagt atcttgctag gactctaaac aggttactga tgcatcacat cagagattgt      660

ttaccagagt tgaaaacaag aataaatgtt ctagctgctc agtatcagtc tcttctaaat      720

agctacggtg aacccgtgga tgataaaagt gctactttac tccaacttat taccaaattt      780

gccacagaat attgtaacac tattgaagga actgcaaaat atattgaaac ttcggagcta      840

tgcggtggtg ctagaatttg ttatattttc catgagactt ttgggcgaac cttagaatct      900

gttgatccac ttggtggcct taacactatt gacattttga ctgccattag aaatgctact      960

ggtcctcgtc ctgctttatt tgtgcctgag gtttcatttg agttactggt gaagcggcaa     1020

atcaaacgtc tagaagagcc cagcctccgc tgtgtggaac tggttcatga ggaaatgcaa     1080

aggatcattc agcactgtag caattacagt acacaggaat tgttacgatt tcctaaactt     1140

catgatgcca tagttgaagt ggtgacttgt cttcttcgta aaaggttgcc tgttacaaat     1200

gaaatggtcc ataacttagt ggcaattgaa ctggcttata tcaacacaaa acatccagac     1260

tttgctgatg cttgtgggct aatgaacaat aatatagagg aacaaaggag aaacaggcta     1320

gccagagaat taccttcagc tgtatcacga gacaagtctt ctaaagttcc aagtgctttg     1380

gcacctgcct cccaggagcc ctcccccgct gcttctgctg aggctgatgg caagttaatt     1440

caggacagca gaagagaaac taaaaatgtt gcatctggag gtggtggggt tggagatggt     1500

gttcaagaac caaccacagg caactggaga ggaatgctga aaacttcaaa agctgaagag     1560

ttattagcag aagaaaaatc aaaacccatt ccaattatgc cagccagtcc acaaaaaggt     1620

catgccgtga acctgctaga tgtgccagtt cctgttgcac gaaaactatc tgctcgggaa     1680

cagcgagatt gtgaggttat tgaacgactc attaaatcat attttctcat tgtcagaaag     1740

aatattcaag acagtgtgcc aaaggcagta atgcattttt tggttaatca tgtgaaagac     1800

actcttcaga gtgagctagt aggccagctg tataaatcat ccttattgga tgatcttctg     1860

acagaatctg aggacatggc acagcgcagg aaagaagcag ctgatatgct aaaggcatta     1920

caaggagcca gtcaaattat tgctgaaatc cgggagactc atctttggtg aagagaacta     1980

tgtaatactg agactttgtt gactcaaaac ttgctagtta ctgcctacct gagtagaatc     2040

ttatttatga actcctgtgt attgcaatgg tatgaatctg ctcatgtgga gactggctat     2100

aaactgaaaa gtgtattcca aattgcagaa cacatcacac atttaatcca aataataaat     2160

ggctgtttct aaagtttccc agtatatata aaatacatca agtctgtctt gtgacagttt     2220

catctgaact taacttaaaa acaactgtta atgttctagt tgtgcaaagc agtttgcctg     2280

tggataagat gacctgtgta ataatctttg ttagtagtct taaagctgct gccatagtcc     2340

tccaagaaga aagcaccaag acaacatttc atatgactat aatgcatgta ctatataagc     2400

tgatctggct ttgaaagatg tgagttggca agttcctcac atagagtcat tgtattccac     2460

ctgtccttca atttagtttt ttctgagctt ctttgcagcc tttgatgtgt ttttaagaaa     2520

gctgaatgca caagaggatc tgtgacactg acatggctgt ggtgtgcata ctgtgtagtt     2580

acatagccct tccaattctg ggtccatttg cactagcaaa ttaaaatatg ctttgattca     2640

tacttaaacc tgaaagcagg aatgcctaca ttaattccta cattaaaaac agccatctac     2700

ccttgattat ctagaaagac ttggtaatga tggtcagttc cttttagatt tcagaaaatc     2760

aaatgatgac ctaaatttcc cttaatttgc aaatacagta gtaattaagg tacatctcta     2820

aagtggagca cttacaccag gctctaagat tcactttgag gtggaactta aaaccagtgt     2880

actgtatgta tgcattggta atagctactt ttgcttcata gcttcatacc aacaaaatat     2940

atttattaga atagtatgaa agtactggag gagctgaaag aaaaacaccc aaggctgggc     3000

gtggtggcac acgcctgtaa tcccagcact ttgggaggcc gaggcaggtg gatcacctga     3060

ggttgggagt tggagaccag cttgaccaac atggagaaac cccgtctcta ctaaaaatac     3120

aaaattggcc gggcgtggtg gcgcatgcct gtaatcccag ctactcggga gggtgaggca     3180

ggagaattgc ttgaccctgg gaggtggagg ttgtggtgag ctaagatcgt gccattgcac     3240

tccagccttg gcaacaagag cgaaactccg tctcaaaaaa aaaaaataaa acaacaccca     3300

gatagataca catactcctt cagacttaca gacctaagct gcatttatgg ggtagtgatg     3360

aggtttagaa catatacata ttttgttaaa attccccaga tgattcttgg tatgaacgac     3420

tatattataa attttaagat gtacttagaa atccttaaga catctagccc cgtctctaat     3480

agacaacaca tttatattgc agatattact tttttttcag tttatgacca ggtatttatg     3540

aaggactatt ggcagggaaa atatgaatat gttaacttta gcttatggca tcaatttact     3600

aaggaacaac aggctcacca actgatgtca aacataaaaa cccccacatc agtctgatac     3660

gatatggtac tactttgaat ctgttactag taccatcttg acagaggata catgctccca     3720

aaacgtttgt taccacactt aaaaatcact gccatcatta agcatcagtt tcaaaattat     3780

agccattcat gatttacttt ttccagatga ctatcattat tctagtcctt tgaatttgta     3840

aggggaaaaa aaacaaaaac aaaaacttac gatgcacttt tctccagcac atcagatttc     3900

aaattgaaaa ttaaagacat gctatggtaa tgcacttgct agtactacac actttgtaca     3960

acaaaaaaca gaggcaagaa acaacggaaa gagaaaagcc ttcctttgtt ggcccttaaa     4020

ctgagtcaag atctgaaatg tagagatgat ctctgacgat acctgtatgt tcttattgtg     4080

taaataaaat tgctggtatg aaatgacact aaagtttgtc aaaaaatgaa ttcttaactt     4140

ttctcccaga gaaagggaga caaaaggagc tttttaatac ctaatctact ttggaacata     4200

accgtataga g                                                          4211


<210> 21
<211> 4543
<212> DNA
<213> Homo sapiens

<400> 21
agcgcatggc ctgccgggag ggggcaggta gccggcgggc ccggtccaat gggtgccggc       60

ttccgaggag agggcggagg agaggaggaa ggaggcgaac tgtgggcccc ggccccattc      120

attgccgtgg ccggcgggca ctggggcccc gtgttttcag agtcatggag gcgctaattc      180

ctgtcataaa caagctccag gacgtcttca acacggtggg cgccgacatc atccagctgc      240

ctcaaatcgt cgtagtggga acgcagagca gcggaaagag ctcagtgcta gaaagcctgg      300

tggggaggga cctgcttccc agaggtactg gaattgtcac ccggagacct ctcattctgc      360

aactggtcca tgtttcacaa gaagataaac ggaaaacaac aggagaagaa aatgaccctg      420

ctacatggaa aaactcaaga cacctttcta aaggggtgga agcagaagaa tggggtaaat      480

ttcttcacac caaaaataag ctttacacgg attttgatga aattcgacaa gaaattgaaa      540

atgaaacaga aagaatttca ggaaataata agggagtaag ccctgaacca attcatctta      600

agattttttc acccaacgtt gtcaatttga cacttgtgga tttgccagga atgaccaagg      660

tgcctgtagg tgatcaacct aaggatattg agcttcaaat cagagagctc attcttcggt      720

tcatcagtaa tcctaattcc attatcctcg ctgtcactgc tgctaataca gatatggcaa      780

catcagaggc acttaaaatt tcaagagagg tagatccaga tggtcgcaga accctagctg      840

taatcactaa acttgatctc atggatgcgg gtactgatgc catggatgta ttgatgggaa      900

gggttattcc agtcaaactt ggaataattg gagtagttaa caggagccag ctagatatta      960

acaacaagaa gagtgtaact gattcaatcc gtgatgagta tgcttttctt caaaagaaat     1020

atccatctct ggccaataga aatggaacaa agtatcttgc taggactcta aacaggttac     1080

tgatgcatca catcagagat tgtttaccag agttgaaaac aagaataaat gttctagctg     1140

ctcagtatca gtctcttcta aatagctacg gtgaacccgt ggatgataaa agtgctactt     1200

tactccaact tattaccaaa tttgccacag aatattgtaa cactattgaa ggaactgcaa     1260

aatatattga aacttcggag ctatgcggtg gtgctagaat ttgttatatt ttccatgaga     1320

cttttgggcg aaccttagaa tctgttgatc cacttggtgg ccttaacact attgacattt     1380

tgactgccat tagaaatgct actggtcctc gtcctgcttt atttgtgcct gaggtttcat     1440

ttgagttact ggtgaagcgg caaatcaaac gtctagaaga gcccagcctc cgctgtgtgg     1500

aactggttca tgaggaaatg caaaggatca ttcagcactg tagcaattac agtacacagg     1560

aattgttacg atttcctaaa cttcatgatg ccatagttga agtggtgact tgtcttcttc     1620

gtaaaaggtt gcctgttaca aatgaaatgg tccataactt agtggcaatt gaactggctt     1680

atatcaacac aaaacatcca gactttgctg atgcttgtgg gctaatgaac aataatatag     1740

aggaacaaag gagaaacagg ctagccagag aattaccttc agctgtatca cgagacaagg     1800

ttgcatctgg aggtggtggg gttggagatg gtgttcaaga accaaccaca ggcaactgga     1860

gaggaatgct gaaaacttca aaagctgaag agttattagc agaagaaaaa tcaaaaccca     1920

ttccaattat gccagccagt ccacaaaaag gtcatgccgt gaacctgcta gatgtgccag     1980

ttcctgttgc acgaaaacta tctgctcggg aacagcgaga ttgtgaggtt attgaacgac     2040

tcattaaatc atattttctc attgtcagaa agaatattca agacagtgtg ccaaaggcag     2100

taatgcattt tttggttaat catgtgaaag acactcttca gagtgagcta gtaggccagc     2160

tgtataaatc atccttattg gatgatcttc tgacagaatc tgaggacatg gcacagcgca     2220

ggaaagaagc agctgatatg ctaaaggcat tacaaggagc cagtcaaatt attgctgaaa     2280

tccgggagac tcatctttgg tgaagagaac tatgtaatac tgagactttg ttgactcaaa     2340

acttgctagt tactgcctac ctgagtagaa tcttatttat gaactcctgt gtattgcaat     2400

ggtatgaatc tgctcatgtg gagactggct ataaactgaa aagtgtattc caaattgcag     2460

aacacatcac acatttaatc caaataataa atggctgttt ctaaagtttc ccagtatata     2520

taaaatacat caagtctgtc ttgtgacagt ttcatctgaa cttaacttaa aaacaactgt     2580

taatgttcta gttgtgcaaa gcagtttgcc tgtggataag atgacctgtg taataatctt     2640

tgttagtagt cttaaagctg ctgccatagt cctccaagaa gaaagcacca agacaacatt     2700

tcatatgact ataatgcatg tactatataa gctgatctgg ctttgaaaga tgtgagttgg     2760

caagttcctc acatagagtc attgtattcc acctgtcctt caatttagtt ttttctgagc     2820

ttctttgcag cctttgatgt gtttttaaga aagctgaatg cacaagagga tctgtgacac     2880

tgacatggct gtggtgtgca tactgtgtag ttacatagcc cttccaattc tgggtccatt     2940

tgcactagca aattaaaata tgctttgatt catacttaaa cctgaaagca ggaatgccta     3000

cattaattcc tacattaaaa acagccatct acccttgatt atctagaaag acttggtaat     3060

gatggtcagt tccttttaga tttcagaaaa tcaaatgatg acctaaattt cccttaattt     3120

gcaaatacag tagtaattaa ggtacatctc taaagtggag cacttacacc aggctctaag     3180

attcactttg aggtggaact taaaaccagt gtactgtatg tatgcattgg taatagctac     3240

ttttgcttca tagcttcata ccaacaaaat atatttatta gaatagtatg aaagtactgg     3300

aggagctgaa agaaaaacac ccaaggctgg gcgtggtggc acacgcctgt aatcccagca     3360

ctttgggagg ccgaggcagg tggatcacct gaggttggga gttggagacc agcttgacca     3420

acatggagaa accccgtctc tactaaaaat acaaaattgg ccgggcgtgg tggcgcatgc     3480

ctgtaatccc agctactcgg gagggtgagg caggagaatt gcttgaccct gggaggtgga     3540

ggttgtggtg agctaagatc gtgccattgc actccagcct tggcaacaag agcgaaactc     3600

cgtctcaaaa aaaaaaaata aaacaacacc cagatagata cacatactcc ttcagactta     3660

cagacctaag ctgcatttat ggggtagtga tgaggtttag aacatataca tattttgtta     3720

aaattcccca gatgattctt ggtatgaacg actatattat aaattttaag atgtacttag     3780

aaatccttaa gacatctagc cccgtctcta atagacaaca catttatatt gcagatatta     3840

cttttttttc agtttatgac caggtattta tgaaggacta ttggcaggga aaatatgaat     3900

atgttaactt tagcttatgg catcaattta ctaaggaaca acaggctcac caactgatgt     3960

caaacataaa aacccccaca tcagtctgat acgatatggt actactttga atctgttact     4020

agtaccatct tgacagagga tacatgctcc caaaacgttt gttaccacac ttaaaaatca     4080

ctgccatcat taagcatcag tttcaaaatt atagccattc atgatttact ttttccagat     4140

gactatcatt attctagtcc tttgaatttg taaggggaaa aaaaacaaaa acaaaaactt     4200

acgatgcact tttctccagc acatcagatt tcaaattgaa aattaaagac atgctatggt     4260

aatgcacttg ctagtactac acactttgta caacaaaaaa cagaggcaag aaacaacgga     4320

aagagaaaag ccttcctttg ttggccctta aactgagtca agatctgaaa tgtagagatg     4380

atctctgacg atacctgtat gttcttattg tgtaaataaa attgctggta tgaaatgaca     4440

ctaaagtttg tcaaaaaatg aattcttaac ttttctccca gagaaaggga gacaaaagga     4500

gctttttaat acctaatcta ctttggaaca taaccgtata gag                       4543


<210> 22
<211> 4504
<212> DNA
<213> Homo sapiens

<400> 22
agcgcatggc ctgccgggag ggggcaggta gccggcgggc ccggtccaat gggtgccggc       60

ttccgaggag agggcggagg agaggaggaa ggaggcgaac tgtgggcccc ggccccattc      120

attgccgtgg ccggcgggca ctggggcccc gtgttttcag agtcatggag gcgctaattc      180

ctgtcataaa caagctccag gacgtcttca acacggtggg cgccgacatc atccagctgc      240

ctcaaatcgt cgtagtggga acgcagagca gcggaaagag ctcagtgcta gaaagcctgg      300

tggggaggga cctgcttccc agaggtactg gaattgtcac ccggagacct ctcattctgc      360

aactggtcca tgtttcacaa gaagataaac ggaaaacaac aggagaagaa aatggggtgg      420

aagcagaaga atggggtaaa tttcttcaca ccaaaaataa gctttacacg gattttgatg      480

aaattcgaca agaaattgaa aatgaaacag aaagaatttc aggaaataat aagggagtaa      540

gccctgaacc aattcatctt aagatttttt cacccaacgt tgtcaatttg acacttgtgg      600

atttgccagg aatgaccaag gtgcctgtag gtgatcaacc taaggatatt gagcttcaaa      660

tcagagagct cattcttcgg ttcatcagta atcctaattc cattatcctc gctgtcactg      720

ctgctaatac agatatggca acatcagagg cacttaaaat ttcaagagag gtagatccag      780

atggtcgcag aaccctagct gtaatcacta aacttgatct catggatgcg ggtactgatg      840

ccatggatgt attgatggga agggttattc cagtcaaact tggaataatt ggagtagtta      900

acaggagcca gctagatatt aacaacaaga agagtgtaac tgattcaatc cgtgatgagt      960

atgcttttct tcaaaagaaa tatccatctc tggccaatag aaatggaaca aagtatcttg     1020

ctaggactct aaacaggtta ctgatgcatc acatcagaga ttgtttacca gagttgaaaa     1080

caagaataaa tgttctagct gctcagtatc agtctcttct aaatagctac ggtgaacccg     1140

tggatgataa aagtgctact ttactccaac ttattaccaa atttgccaca gaatattgta     1200

acactattga aggaactgca aaatatattg aaacttcgga gctatgcggt ggtgctagaa     1260

tttgttatat tttccatgag acttttgggc gaaccttaga atctgttgat ccacttggtg     1320

gccttaacac tattgacatt ttgactgcca ttagaaatgc tactggtcct cgtcctgctt     1380

tatttgtgcc tgaggtttca tttgagttac tggtgaagcg gcaaatcaaa cgtctagaag     1440

agcccagcct ccgctgtgtg gaactggttc atgaggaaat gcaaaggatc attcagcact     1500

gtagcaatta cagtacacag gaattgttac gatttcctaa acttcatgat gccatagttg     1560

aagtggtgac ttgtcttctt cgtaaaaggt tgcctgttac aaatgaaatg gtccataact     1620

tagtggcaat tgaactggct tatatcaaca caaaacatcc agactttgct gatgcttgtg     1680

ggctaatgaa caataatata gaggaacaaa ggagaaacag gctagccaga gaattacctt     1740

cagctgtatc acgagacaag gttgcatctg gaggtggtgg ggttggagat ggtgttcaag     1800

aaccaaccac aggcaactgg agaggaatgc tgaaaacttc aaaagctgaa gagttattag     1860

cagaagaaaa atcaaaaccc attccaatta tgccagccag tccacaaaaa ggtcatgccg     1920

tgaacctgct agatgtgcca gttcctgttg cacgaaaact atctgctcgg gaacagcgag     1980

attgtgaggt tattgaacga ctcattaaat catattttct cattgtcaga aagaatattc     2040

aagacagtgt gccaaaggca gtaatgcatt ttttggttaa tcatgtgaaa gacactcttc     2100

agagtgagct agtaggccag ctgtataaat catccttatt ggatgatctt ctgacagaat     2160

ctgaggacat ggcacagcgc aggaaagaag cagctgatat gctaaaggca ttacaaggag     2220

ccagtcaaat tattgctgaa atccgggaga ctcatctttg gtgaagagaa ctatgtaata     2280

ctgagacttt gttgactcaa aacttgctag ttactgccta cctgagtaga atcttattta     2340

tgaactcctg tgtattgcaa tggtatgaat ctgctcatgt ggagactggc tataaactga     2400

aaagtgtatt ccaaattgca gaacacatca cacatttaat ccaaataata aatggctgtt     2460

tctaaagttt cccagtatat ataaaataca tcaagtctgt cttgtgacag tttcatctga     2520

acttaactta aaaacaactg ttaatgttct agttgtgcaa agcagtttgc ctgtggataa     2580

gatgacctgt gtaataatct ttgttagtag tcttaaagct gctgccatag tcctccaaga     2640

agaaagcacc aagacaacat ttcatatgac tataatgcat gtactatata agctgatctg     2700

gctttgaaag atgtgagttg gcaagttcct cacatagagt cattgtattc cacctgtcct     2760

tcaatttagt tttttctgag cttctttgca gcctttgatg tgtttttaag aaagctgaat     2820

gcacaagagg atctgtgaca ctgacatggc tgtggtgtgc atactgtgta gttacatagc     2880

ccttccaatt ctgggtccat ttgcactagc aaattaaaat atgctttgat tcatacttaa     2940

acctgaaagc aggaatgcct acattaattc ctacattaaa aacagccatc tacccttgat     3000

tatctagaaa gacttggtaa tgatggtcag ttccttttag atttcagaaa atcaaatgat     3060

gacctaaatt tcccttaatt tgcaaataca gtagtaatta aggtacatct ctaaagtgga     3120

gcacttacac caggctctaa gattcacttt gaggtggaac ttaaaaccag tgtactgtat     3180

gtatgcattg gtaatagcta cttttgcttc atagcttcat accaacaaaa tatatttatt     3240

agaatagtat gaaagtactg gaggagctga aagaaaaaca cccaaggctg ggcgtggtgg     3300

cacacgcctg taatcccagc actttgggag gccgaggcag gtggatcacc tgaggttggg     3360

agttggagac cagcttgacc aacatggaga aaccccgtct ctactaaaaa tacaaaattg     3420

gccgggcgtg gtggcgcatg cctgtaatcc cagctactcg ggagggtgag gcaggagaat     3480

tgcttgaccc tgggaggtgg aggttgtggt gagctaagat cgtgccattg cactccagcc     3540

ttggcaacaa gagcgaaact ccgtctcaaa aaaaaaaaat aaaacaacac ccagatagat     3600

acacatactc cttcagactt acagacctaa gctgcattta tggggtagtg atgaggttta     3660

gaacatatac atattttgtt aaaattcccc agatgattct tggtatgaac gactatatta     3720

taaattttaa gatgtactta gaaatcctta agacatctag ccccgtctct aatagacaac     3780

acatttatat tgcagatatt actttttttt cagtttatga ccaggtattt atgaaggact     3840

attggcaggg aaaatatgaa tatgttaact ttagcttatg gcatcaattt actaaggaac     3900

aacaggctca ccaactgatg tcaaacataa aaacccccac atcagtctga tacgatatgg     3960

tactactttg aatctgttac tagtaccatc ttgacagagg atacatgctc ccaaaacgtt     4020

tgttaccaca cttaaaaatc actgccatca ttaagcatca gtttcaaaat tatagccatt     4080

catgatttac tttttccaga tgactatcat tattctagtc ctttgaattt gtaaggggaa     4140

aaaaaacaaa aacaaaaact tacgatgcac ttttctccag cacatcagat ttcaaattga     4200

aaattaaaga catgctatgg taatgcactt gctagtacta cacactttgt acaacaaaaa     4260

acagaggcaa gaaacaacgg aaagagaaaa gccttccttt gttggccctt aaactgagtc     4320

aagatctgaa atgtagagat gatctctgac gatacctgta tgttcttatt gtgtaaataa     4380

aattgctggt atgaaatgac actaaagttt gtcaaaaaat gaattcttaa cttttctccc     4440

agagaaaggg agacaaaagg agctttttaa tacctaatct actttggaac ataaccgtat     4500

agag                                                                  4504


<210> 23
<211> 4514
<212> DNA
<213> Homo sapiens

<400> 23
gtgggccccg gccccattca ttgccgtggc cggcgggcac tggggccccg tgttttcaga       60

gtcatggagg cgctaattcc tgtcataaac aagctccagg acgtcttcaa cacggtgggc      120

gccgacatca tccagctgcc tcaaatcgtc gtagtgggaa cgcagagcag cggaaagagc      180

tcagtgctag aaagcctggt ggggagggac ctgcttccca gaggtactgg aattgtcacc      240

cggagacctc tcattctgca actggtccat gtttcacaag aagataaacg gaaaacaaca      300

ggagaagaaa atggggtgga agcagaagaa tggggtaaat ttcttcacac caaaaataag      360

ctttacacgg attttgatga aattcgacaa gaaattgaaa atgaaacaga aagaatttca      420

ggaaataata agggagtaag ccctgaacca attcatctta agattttttc acccaacgtt      480

gtcaatttga cacttgtgga tttgccagga atgaccaagg tgcctgtagg tgatcaacct      540

aaggatattg agcttcaaat cagagagctc attcttcggt tcatcagtaa tcctaattcc      600

attatcctcg ctgtcactgc tgctaataca gatatggcaa catcagaggc acttaaaatt      660

tcaagagagg tagatccaga tggtcgcaga accctagctg taatcactaa acttgatctc      720

atggatgcgg gtactgatgc catggatgta ttgatgggaa gggttattcc agtcaaactt      780

ggaataattg gagtagttaa caggagccag ctagatatta acaacaagaa gagtgtaact      840

gattcaatcc gtgatgagta tgcttttctt caaaagaaat atccatctct ggccaataga      900

aatggaacaa agtatcttgc taggactcta aacaggttac tgatgcatca catcagagat      960

tgtttaccag agttgaaaac aagaataaat gttctagctg ctcagtatca gtctcttcta     1020

aatagctacg gtgaacccgt ggatgataaa agtgctactt tactccaact tattaccaaa     1080

tttgccacag aatattgtaa cactattgaa ggaactgcaa aatatattga aacttcggag     1140

ctatgcggtg gtgctagaat ttgttatatt ttccatgaga cttttgggcg aaccttagaa     1200

tctgttgatc cacttggtgg ccttaacact attgacattt tgactgccat tagaaatgct     1260

actggtcctc gtcctgcttt atttgtgcct gaggtttcat ttgagttact ggtgaagcgg     1320

caaatcaaac gtctagaaga gcccagcctc cgctgtgtgg aactggttca tgaggaaatg     1380

caaaggatca ttcagcactg tagcaattac agtacacagg aattgttacg atttcctaaa     1440

cttcatgatg ccatagttga agtggtgact tgtcttcttc gtaaaaggtt gcctgttaca     1500

aatgaaatgg tccataactt agtggcaatt gaactggctt atatcaacac aaaacatcca     1560

gactttgctg atgcttgtgg gctaatgaac aataatatag aggaacaaag gagaaacagg     1620

ctagccagag aattaccttc agctgtatca cgagacaagt cttctaaagt tccaagtgct     1680

ttggcacctg cctcccagga gccctccccc gctgcttctg ctgaggctga tggcaagtta     1740

attcaggaca gcagaagaga aactaaaaat gttgcatctg gaggtggtgg ggttggagat     1800

ggtgttcaag aaccaaccac aggcaactgg agaggaatgc tgaaaacttc aaaagctgaa     1860

gagttattag cagaagaaaa atcaaaaccc attccaatta tgccagccag tccacaaaaa     1920

ggtcatgccg tgaacctgct agatgtgcca gttcctgttg cacgaaaact atctgctcgg     1980

gaacagcgag attgtgaggt tattgaacga ctcattaaat catattttct cattgtcaga     2040

aagaatattc aagacagtgt gccaaaggca gtaatgcatt ttttggttaa tcatgtgaaa     2100

gacactcttc agagtgagct agtaggccag ctgtataaat catccttatt ggatgatctt     2160

ctgacagaat ctgaggacat ggcacagcgc aggaaagaag cagctgatat gctaaaggca     2220

ttacaaggag ccagtcaaat tattgctgaa atccgggaga ctcatctttg gtgaagagaa     2280

ctatgtaata ctgagacttt gttgactcaa aacttgctag ttactgccta cctgagtaga     2340

atcttattta tgaactcctg tgtattgcaa tggtatgaat ctgctcatgt ggagactggc     2400

tataaactga aaagtgtatt ccaaattgca gaacacatca cacatttaat ccaaataata     2460

aatggctgtt tctaaagttt cccagtatat ataaaataca tcaagtctgt cttgtgacag     2520

tttcatctga acttaactta aaaacaactg ttaatgttct agttgtgcaa agcagtttgc     2580

ctgtggataa gatgacctgt gtaataatct ttgttagtag tcttaaagct gctgccatag     2640

tcctccaaga agaaagcacc aagacaacat ttcatatgac tataatgcat gtactatata     2700

agctgatctg gctttgaaag atgtgagttg gcaagttcct cacatagagt cattgtattc     2760

cacctgtcct tcaatttagt tttttctgag cttctttgca gcctttgatg tgtttttaag     2820

aaagctgaat gcacaagagg atctgtgaca ctgacatggc tgtggtgtgc atactgtgta     2880

gttacatagc ccttccaatt ctgggtccat ttgcactagc aaattaaaat atgctttgat     2940

tcatacttaa acctgaaagc aggaatgcct acattaattc ctacattaaa aacagccatc     3000

tacccttgat tatctagaaa gacttggtaa tgatggtcag ttccttttag atttcagaaa     3060

atcaaatgat gacctaaatt tcccttaatt tgcaaataca gtagtaatta aggtacatct     3120

ctaaagtgga gcacttacac caggctctaa gattcacttt gaggtggaac ttaaaaccag     3180

tgtactgtat gtatgcattg gtaatagcta cttttgcttc atagcttcat accaacaaaa     3240

tatatttatt agaatagtat gaaagtactg gaggagctga aagaaaaaca cccaaggctg     3300

ggcgtggtgg cacacgcctg taatcccagc actttgggag gccgaggcag gtggatcacc     3360

tgaggttggg agttggagac cagcttgacc aacatggaga aaccccgtct ctactaaaaa     3420

tacaaaattg gccgggcgtg gtggcgcatg cctgtaatcc cagctactcg ggagggtgag     3480

gcaggagaat tgcttgaccc tgggaggtgg aggttgtggt gagctaagat cgtgccattg     3540

cactccagcc ttggcaacaa gagcgaaact ccgtctcaaa aaaaaaaaat aaaacaacac     3600

ccagatagat acacatactc cttcagactt acagacctaa gctgcattta tggggtagtg     3660

atgaggttta gaacatatac atattttgtt aaaattcccc agatgattct tggtatgaac     3720

gactatatta taaattttaa gatgtactta gaaatcctta agacatctag ccccgtctct     3780

aatagacaac acatttatat tgcagatatt actttttttt cagtttatga ccaggtattt     3840

atgaaggact attggcaggg aaaatatgaa tatgttaact ttagcttatg gcatcaattt     3900

actaaggaac aacaggctca ccaactgatg tcaaacataa aaacccccac atcagtctga     3960

tacgatatgg tactactttg aatctgttac tagtaccatc ttgacagagg atacatgctc     4020

ccaaaacgtt tgttaccaca cttaaaaatc actgccatca ttaagcatca gtttcaaaat     4080

tatagccatt catgatttac tttttccaga tgactatcat tattctagtc ctttgaattt     4140

gtaaggggaa aaaaaacaaa aacaaaaact tacgatgcac ttttctccag cacatcagat     4200

ttcaaattga aaattaaaga catgctatgg taatgcactt gctagtacta cacactttgt     4260

acaacaaaaa acagaggcaa gaaacaacgg aaagagaaaa gccttccttt gttggccctt     4320

aaactgagtc aagatctgaa atgtagagat gatctctgac gatacctgta tgttcttatt     4380

gtgtaaataa aattgctggt atgaaatgac actaaagttt gtcaaaaaat gaattcttaa     4440

cttttctccc agagaaaggg agacaaaagg agctttttaa tacctaatct actttggaac     4500

ataaccgtat agag                                                       4514


<210> 24
<211> 4537
<212> DNA
<213> Homo sapiens

<400> 24
agcgcatggc ctgccgggag ggggcaggta gccggcgggc ccggtccaat gggtgccggc       60

ttccgaggag agggcggagg agaggaggaa ggaggcgaac tgtgggcccc ggccccattc      120

attgccgtgg ccggcgggca ctggggcccc gtgttttcag agtcatggag gcgctaattc      180

ctgtcataaa caagctccag gacgtcttca acacggtggg cgccgacatc atccagctgc      240

ctcaaatcgt cgtagtggga acgcagagca gcggaaagag ctcagtgcta gaaagcctgg      300

tggggaggga cctgcttccc agaggtactg gaattgtcac ccggagacct ctcattctgc      360

aactggtcca tgtttcacaa gaagataaac ggaaaacaac aggagaagaa aatggggtgg      420

aagcagaaga atggggtaaa tttcttcaca ccaaaaataa gctttacacg gattttgatg      480

aaattcgaca agaaattgaa aatgaaacag aaagaatttc aggaaataat aagggagtaa      540

gccctgaacc aattcatctt aagatttttt cacccaacgt tgtcaatttg acacttgtgg      600

atttgccagg aatgaccaag gtgcctgtag gtgatcaacc taaggatatt gagcttcaaa      660

tcagagagct cattcttcgg ttcatcagta atcctaattc cattatcctc gctgtcactg      720

ctgctaatac agatatggca acatcagagg cacttaaaat ttcaagagag gtagatccag      780

atggtcgcag aaccctagct gtaatcacta aacttgatct catggatgcg ggtactgatg      840

ccatggatgt attgatggga agggttattc cagtcaaact tggaataatt ggagtagtta      900

acaggagcca gctagatatt aacaacaaga agagtgtaac tgattcaatc cgtgatgagt      960

atgcttttct tcaaaagaaa tatccatctc tggccaatag aaatggaaca aagtatcttg     1020

ctaggactct aaacaggtta ctgatgcatc acatcagaga ttgtttacca gagttgaaaa     1080

caagaataaa tgttctagct gctcagtatc agtctcttct aaatagctac ggtgaacccg     1140

tggatgataa aagtgctact ttactccaac ttattaccaa atttgccaca gaatattgta     1200

acactattga aggaactgca aaatatattg aaacttcgga gctatgcggt ggtgctagaa     1260

tttgttatat tttccatgag acttttgggc gaaccttaga atctgttgat ccacttggtg     1320

gccttaacac tattgacatt ttgactgcca ttagaaatgc tactggtcct cgtcctgctt     1380

tatttgtgcc tgaggtttca tttgagttac tggtgaagcg gcaaatcaaa cgtctagaag     1440

agcccagcct ccgctgtgtg gaactggttc atgaggaaat gcaaaggatc attcagcact     1500

gtagcaatta cagtacacag gaattgttac gatttcctaa acttcatgat gccatagttg     1560

aagtggtgac ttgtcttctt cgtaaaaggt tgcctgttac aaatgaaatg gtccataact     1620

tagtggcaat tgaactggct tatatcaaca caaaacatcc agactttgct gatgcttgtg     1680

ggctaatgaa caataatata gaggaacaaa ggagaaacag gctagccaga gaattacctt     1740

cagctgtatc acgagacaag ttaattcagg acagcagaag agaaactaaa aatgttgcat     1800

ctggaggtgg tggggttgga gatggtgttc aagaaccaac cacaggcaac tggagaggaa     1860

tgctgaaaac ttcaaaagct gaagagttat tagcagaaga aaaatcaaaa cccattccaa     1920

ttatgccagc cagtccacaa aaaggtcatg ccgtgaacct gctagatgtg ccagttcctg     1980

ttgcacgaaa actatctgct cgggaacagc gagattgtga ggttattgaa cgactcatta     2040

aatcatattt tctcattgtc agaaagaata ttcaagacag tgtgccaaag gcagtaatgc     2100

attttttggt taatcatgtg aaagacactc ttcagagtga gctagtaggc cagctgtata     2160

aatcatcctt attggatgat cttctgacag aatctgagga catggcacag cgcaggaaag     2220

aagcagctga tatgctaaag gcattacaag gagccagtca aattattgct gaaatccggg     2280

agactcatct ttggtgaaga gaactatgta atactgagac tttgttgact caaaacttgc     2340

tagttactgc ctacctgagt agaatcttat ttatgaactc ctgtgtattg caatggtatg     2400

aatctgctca tgtggagact ggctataaac tgaaaagtgt attccaaatt gcagaacaca     2460

tcacacattt aatccaaata ataaatggct gtttctaaag tttcccagta tatataaaat     2520

acatcaagtc tgtcttgtga cagtttcatc tgaacttaac ttaaaaacaa ctgttaatgt     2580

tctagttgtg caaagcagtt tgcctgtgga taagatgacc tgtgtaataa tctttgttag     2640

tagtcttaaa gctgctgcca tagtcctcca agaagaaagc accaagacaa catttcatat     2700

gactataatg catgtactat ataagctgat ctggctttga aagatgtgag ttggcaagtt     2760

cctcacatag agtcattgta ttccacctgt ccttcaattt agttttttct gagcttcttt     2820

gcagcctttg atgtgttttt aagaaagctg aatgcacaag aggatctgtg acactgacat     2880

ggctgtggtg tgcatactgt gtagttacat agcccttcca attctgggtc catttgcact     2940

agcaaattaa aatatgcttt gattcatact taaacctgaa agcaggaatg cctacattaa     3000

ttcctacatt aaaaacagcc atctaccctt gattatctag aaagacttgg taatgatggt     3060

cagttccttt tagatttcag aaaatcaaat gatgacctaa atttccctta atttgcaaat     3120

acagtagtaa ttaaggtaca tctctaaagt ggagcactta caccaggctc taagattcac     3180

tttgaggtgg aacttaaaac cagtgtactg tatgtatgca ttggtaatag ctacttttgc     3240

ttcatagctt cataccaaca aaatatattt attagaatag tatgaaagta ctggaggagc     3300

tgaaagaaaa acacccaagg ctgggcgtgg tggcacacgc ctgtaatccc agcactttgg     3360

gaggccgagg caggtggatc acctgaggtt gggagttgga gaccagcttg accaacatgg     3420

agaaaccccg tctctactaa aaatacaaaa ttggccgggc gtggtggcgc atgcctgtaa     3480

tcccagctac tcgggagggt gaggcaggag aattgcttga ccctgggagg tggaggttgt     3540

ggtgagctaa gatcgtgcca ttgcactcca gccttggcaa caagagcgaa actccgtctc     3600

aaaaaaaaaa aataaaacaa cacccagata gatacacata ctccttcaga cttacagacc     3660

taagctgcat ttatggggta gtgatgaggt ttagaacata tacatatttt gttaaaattc     3720

cccagatgat tcttggtatg aacgactata ttataaattt taagatgtac ttagaaatcc     3780

ttaagacatc tagccccgtc tctaatagac aacacattta tattgcagat attacttttt     3840

tttcagttta tgaccaggta tttatgaagg actattggca gggaaaatat gaatatgtta     3900

actttagctt atggcatcaa tttactaagg aacaacaggc tcaccaactg atgtcaaaca     3960

taaaaacccc cacatcagtc tgatacgata tggtactact ttgaatctgt tactagtacc     4020

atcttgacag aggatacatg ctcccaaaac gtttgttacc acacttaaaa atcactgcca     4080

tcattaagca tcagtttcaa aattatagcc attcatgatt tactttttcc agatgactat     4140

cattattcta gtcctttgaa tttgtaaggg gaaaaaaaac aaaaacaaaa acttacgatg     4200

cacttttctc cagcacatca gatttcaaat tgaaaattaa agacatgcta tggtaatgca     4260

cttgctagta ctacacactt tgtacaacaa aaaacagagg caagaaacaa cggaaagaga     4320

aaagccttcc tttgttggcc cttaaactga gtcaagatct gaaatgtaga gatgatctct     4380

gacgatacct gtatgttctt attgtgtaaa taaaattgct ggtatgaaat gacactaaag     4440

tttgtcaaaa aatgaattct taacttttct cccagagaaa gggagacaaa aggagctttt     4500

taatacctaa tctactttgg aacataaccg tatagag                              4537


<210> 25
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala 
    50  


