                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  HIGH AFFINITY MONOCLONAL ANTIBODIES TARGETING GLYPICAN-2 AND USES
        THEREOF

<130>  4239-101087-02

<150>  US 62/716,169
<151>  2018-08-08

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
gaggtccagc tgcaacagtc tggacctgaa ctggtgaagc ctggggcttc agtaaagatg       60

tcctgcaagg cttctagatt cacattcact gactacaaca tacactgggt gaagcagagc      120

cctggaaaga cccttgaatg gattggatat attaacccta acaatggtga tattttctac      180

aaacagaagt tcaatggcaa ggccacattg actataaaca agtcctccaa cacagcctac      240

atggagctcc gcagcctgac atcggaggat tctgcagtct attactgtgt aagatcctct      300

aatattcgtt atactttcga caggttcttc gatgtctggg gcacagggac cacggtcacc      360

gtctcctca                                                              369


<210>  2
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Arg Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser Pro Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Asp Ile Phe Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Ile Asn Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Ser Asn Ile Arg Tyr Thr Phe Asp Arg Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  3
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
gaaaatgtgc tcacccagtc tccagcaatc atgtctgcat ctctagggga gaaggtcacc       60

atgagctgca gggccagctc aagtgtaaat tacatttact ggtaccagca gaagtcagat      120

gcctccccca aactatggat ttattacaca tccaacctgg ctcctggagt cccagctcgc      180

ttcagtggca gtgggtctgg gaactcttat tctctcacaa tcagcagcat ggagggtgaa      240

gatgctgcca cttattactg ccagcagttt tctagttccc catccacgtt cggtactggg      300

accaagctgg agctgaaa                                                    318


<210>  4
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val Asn Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Gly Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Ser Ser Ser Pro Ser Thr 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  5
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
gaggtgaaac tggtggagtc tggaggaggc ttggtacagt ctgggcgttc tctgagactc       60

tcctgtgcaa cttctggatt caccttcagt gatttctaca tggagtgggt ccgccaagct      120

ccagggaagg gactggagtg gattgttgca agtagagaca aagctaatga ttatacaaca      180

gcgtatagtg catctgtgaa gggtcggttc atcgtctcca gagacacttc ccaaagcatc      240

ctctaccttc agatgaatgc cctgagagct gaggacactg ccatttatta ctgtgtaaga      300

gatttctatg attacgacga ggcttactgg ggccaaggga ctctggtcac tgtctct         357


<210>  6
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Val Ala Ser Arg Asp Lys Ala Asn Asp Tyr Thr Thr Ala Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Phe Tyr Asp Tyr Asp Glu Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  7
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
gacatccaga tgactcagtc tccgtcctca ctgtctgcct ctctgggagg tacagtcacc       60

atcacttgca aggcaagcga agacattaac aactatatag cttggtacca acacaagcct      120

ggaaaaggtc ctcggctgct catacaatac acatctacat tacagccagg catcccatca      180

aggttcagtg gaagtgggtc tgggcgagat tattccctca gcatcagcaa cctggagcct      240

gaagatattg caacttatta ttgtctacag tatgatattc tgtggacgtt cggtggaggc      300

accaagctgg aaatcaaa                                                    318


<210>  8
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


Gln Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Leu Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ile Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  9
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Arg Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser Pro Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Asp Ile Phe Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Ile Asn Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Ser Asn Ile Arg Tyr Thr Phe Asp Arg Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu Lys Val Thr Met Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Asn Tyr Ile Tyr Trp Tyr Gln Gln Lys 
                165                 170                 175     


Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr Tyr Thr Ser Asn Leu Ala 
            180                 185                 190         


Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Ser Met Glu Gly Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Ser Ser Ser Pro Ser Thr Phe Gly Thr Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys 
                


<210>  10
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Arg Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Asp Ile Phe Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Asn Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Ser Asn Ile Arg Tyr Thr Phe Asp Arg Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Asn Tyr Ile Tyr Trp Tyr Leu Gln Lys Pro 
                165                 170                 175     


Gly Gln Ser Pro Gln Leu Trp Ile Tyr Tyr Thr Ser Asn Leu Ala Pro 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Ser Ser Ser Pro Ser Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  11
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Arg Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Asp Ile Phe Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Asn Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Ser Asn Ile Arg Tyr Thr Phe Asp Arg Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Ala Phe Leu Ser Val Thr Pro Gly Glu Lys Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Asn Tyr Ile Tyr Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Asp Gln Ala Pro Lys Leu Trp Ile Tyr Tyr Thr Ser Asn Leu Ala Pro 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Phe Thr Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Ser Ser Ser Pro Ser Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  12
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Arg Phe Thr Phe Thr Asp 
            20                  25                  30          


Tyr Asn Ile His Trp Val Lys Gln Ser His Gly Lys Cys Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Pro Asn Asn Gly Asp Ile Phe Tyr Lys Gln Lys 
    50                  55                  60                  


Phe Asn Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Val Arg Ser Ser Asn Ile Arg Tyr Thr Phe Asp Arg Phe Phe Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Ile Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Ser Gly Thr Ser Pro Lys Leu Trp Ile Tyr Tyr Thr Ser Asn Leu 
            180                 185                 190         


Ala Pro Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Phe Ser Ser Ser Pro Ser Thr Phe Gly Cys Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  


<210>  14
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  15
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  15

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  16
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  17
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  18
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  20
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  21
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Arg Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Asp Ile Phe Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Ser Asn Ile Arg Tyr Thr Phe Asp Arg Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Asn Tyr Ile Tyr Trp Tyr Gln Gln Lys Ser 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Trp Ile Tyr Tyr Thr Ser Asn Leu Ala Pro 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Phe Ser Ser Ser Pro Ser Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  22
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Ser Ala Ala Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu Ala Ala 
1               5                   10                  15      


Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg 
            20                  25                  30          


His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro 
        35                  40                  45              


Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn 
    50                  55                  60                  


Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly 
65                  70                  75                  80  


Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu 
                85                  90                  95      


Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly 
            100                 105                 110         


Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp Ser Gly 
        115                 120                 125             


Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly 
    130                 135                 140                 


Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr 
145                 150                 155                 160 


Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr 
                165                 170                 175     


Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile 
            180                 185                 190         


Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp 
        195                 200                 205             


Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala 
    210                 215                 220                 


Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu 
225                 230                 235                 240 


Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr 
                245                 250                 255     


Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu 
            260                 265                 270         


Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu 
        275                 280                 285             


Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu 
    290                 295                 300                 


Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val 
305                 310                 315                 320 


Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile 
                325                 330                 335     


Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu 
            340                 345                 350         


Asp Leu Lys 
        355 


<210>  23
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Lys Leu Lys Ala Ser Gly Gly Arg His Arg Gln Pro Arg Gly Trp Glu 
1               5                   10                  15      


Gln Leu Gly Gly Gly Gly Gly Ser Pro Thr Gly Ala Glu Phe Leu Gly 
            20                  25                  30          


Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr 
        35                  40                  45              


Val Glu Arg Leu Leu Gln Ala His Ala Gln Leu Glu Glu Arg Gly Tyr 
    50                  55                  60                  


Val Phe Val Gly Tyr His Gly Thr Ala Leu Glu Ala Ala Gln Ser Ile 
65                  70                  75                  80  


Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp 
                85                  90                  95      


Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala His Ala Tyr Gly Tyr Ala 
            100                 105                 110         


Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Ala Asn Gly Ala Leu 
        115                 120                 125             


Leu Arg Val Tyr Val Pro Ala Ser Ser Leu Pro Gly Phe Tyr Arg Thr 
    130                 135                 140                 


Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu 
145                 150                 155                 160 


Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu 
                165                 170                 175     


Glu Glu Gly Gly Arg Glu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu 
            180                 185                 190         


Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val 
        195                 200                 205             


Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile 
    210                 215                 220                 


Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu 
225                 230                 235                 240 


Asp Leu Lys 
            


